2026

Complement inhibition for acute neuromyelitis optica spectrum disorder attacks: insights from an international case series.
Rommer, Paulus S. ORCID: https://orcid.org/0000-0001-5209-6647, Jiang, Wei ORCID: https://orcid.org/0000-0002-0811-0648, Nolte, Jan P. ORCID: https://orcid.org/0009-0002-6073-8384, Mikami, Takahisa ORCID: https://orcid.org/0000-0003-1851-5259, De Seze, Jerome ORCID: https://orcid.org/0000-0002-7197-7578, Sánchez, Pedro, Harel, Asaff ORCID: https://orcid.org/0000-0002-3527-0938, Alkabie, Samir ORCID: https://orcid.org/0000-0001-5596-514X, Kaneko, Kimihiko ORCID: https://orcid.org/0000-0001-8469-9338, Bilodeau, Philippe A. ORCID: https://orcid.org/0000-0002-2672-554X, Misu, Tatsuro ORCID: https://orcid.org/0000-0002-7311-2578, Kremer, Laurent ORCID: https://orcid.org/0000-0002-7246-2533, Bigaut, Kévin ORCID: https://orcid.org/0000-0002-5176-580X, Leypoldt, Frank ORCID: https://orcid.org/0000-0002-8972-515X, Aktas, Orhan ORCID: https://orcid.org/0000-0002-2020-9210, Ringelstein, Marius ORCID: https://orcid.org/0000-0003-3618-8407, Siffrin, Volker ORCID: https://orcid.org/0000-0002-1532-2868, Zhang, Lin-Jie ORCID: https://orcid.org/0000-0002-6100-4115, Cong, Hengri ORCID: https://orcid.org/0009-0005-8476-8379, Lowe, Mallory ORCID: https://orcid.org/0000-0002-9270-2979, Barreras, Paula ORCID: https://orcid.org/0000-0002-3837-7183, Chen, Haiwen ORCID: https://orcid.org/0000-0003-1598-3903, Piquet, Amanda L. ORCID: https://orcid.org/0000-0001-7349-6455, Sotirchos, Elias S. ORCID: https://orcid.org/0000-0002-8812-1637, Kammeyer, Ryan, Zook, Jadyn ORCID: https://orcid.org/0000-0001-8657-3106, Bennett, Jeffrey L. ORCID: https://orcid.org/0000-0002-3346-1394, Berger, Thomas ORCID: https://orcid.org/0000-0001-5626-1144, Fujihara, Kazuo ORCID: https://orcid.org/0000-0002-3096-4156, Levy, Michael ORCID: https://orcid.org/0000-0002-7969-8346, Shi, Fu-Dong ORCID: https://orcid.org/0000-0002-9675-4637 and Paul, Friedemann ORCID: https://orcid.org/0000-0002-6378-0070
Neurology Neuroimmunology & Neuroinflammation 13 (2): e200548. March 2026

2025

Pathways to progressive disability in multiple sclerosis: the role of glial cells in chronic CNS inflammation.
Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868
Glia 73 (10): 1928-1950. October 2025

Mapping CD4+ T cell diversity in CSF to identify endophenotypes of multiple sclerosis.
Crowley, T., Chen, J. ORCID: https://orcid.org/0000-0002-4355-4121, Rosiewicz, K.S. ORCID: https://orcid.org/0000-0002-6926-7227, Jopp-Saile, L. ORCID: https://orcid.org/0000-0002-7032-3003, Herold, G., Biese, C., Fischer, C. ORCID: https://orcid.org/0000-0003-0329-2435, Kerkering, J. ORCID: https://orcid.org/0000-0002-6432-7104, Alisch, M. ORCID: https://orcid.org/0009-0000-8316-6193, Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070 and Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868
Brain Communications 7 (3): fcaf231. 19 June 2025

Pegivirus-associated encephalomyelitis in immunosuppressed patients.
Scheibe, F., Melchert, J., Radbruch, H. ORCID: https://orcid.org/0000-0001-6941-3397, Siebert, E., Best, T.D., Kohler, S., Fitzek, M., Kowski, A., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Meinhardt, J., Raspe, R., Horst, V., Zukunft, B., Budde, K., van Landeghem, F.K.H., Power, C., Eckardt, K.U., Endres, M., Drosten, C., Corman, V.M. and Ruprecht, K.
New England Journal of Medicine 392 (18): 1864-1866. 8 May 2025

Distinguishing neuromyelitis optica spectrum disorders subtypes: a study on AQP4 and C3d epitope expression in cytokine-primed human astrocytes.
Alisch, M. ORCID: https://orcid.org/0009-0000-8316-6193, Foersterling, F., Zocholl, D., Muinjonov, B., Schindler, P., Duchnow, A., Otto, C., Ruprecht, K., Schmitz-Hübsch, T. ORCID: https://orcid.org/0000-0003-4833-5937, Jarius, S., Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070 and Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868
Glia 73 (5): 1090-1106. May 2025

Recurrent late-onset neutropenia after ofatumumab treatment in a case of multiple sclerosis.
Chen, J. ORCID: https://orcid.org/0000-0002-4355-4121, Burmeister, T., Frankenstein, L., Laumeier, I. and Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868
Neurological Research and Practice 7 (1): 20. 24 March 2025

2024

Reevaluating the relevance of F-FDG PET findings for diagnosis of neurosarcoidosis: a case series.
Chen, J. ORCID: https://orcid.org/0000-0002-4355-4121, Metzger, G., Furth, C., Bohner, G. and Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868
Neurological Research and Practice 6 (1): 12. 25 January 2024

2023

HIF prolyl hydroxylase 2/3 deletion disrupts astrocytic integrity and exacerbates neuroinflammation.
Rosiewicz, K.S. ORCID: https://orcid.org/0000-0002-6926-7227, Muinjonov, B., Kunz, S. ORCID: https://orcid.org/0000-0002-0131-3506, Radbruch, H. ORCID: https://orcid.org/0000-0001-6941-3397, Chen, J. ORCID: https://orcid.org/0000-0002-4355-4121, Jüttner, R. ORCID: https://orcid.org/0000-0003-3565-0698, Kerkering, J. ORCID: https://orcid.org/0000-0002-6432-7104, Ucar, J., Crowley, T., Wielockx, B., Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070, Alisch, M. ORCID: https://orcid.org/0009-0000-8316-6193 and Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868
Glia 71 (8): 2024-2044. August 2023

iPSC-derived reactive astrocytes from patients with multiple-sclerosis protect cocultured neurons in inflammatory conditions.
Kerkering, J. ORCID: https://orcid.org/0000-0002-6432-7104, Muinjonov, B., Rosiewicz, K.S. ORCID: https://orcid.org/0000-0002-6926-7227, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Biese, C., Schiweck, J., Chien, C. ORCID: https://orcid.org/0000-0001-8280-9513, Zocholl, D., Conrad, T. ORCID: https://orcid.org/0000-0001-5618-6295, Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070, Alisch, M. ORCID: https://orcid.org/0009-0000-8316-6193 and Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868
Journal of Clinical Investigation 133 (13): e164637. 3 July 2023

Inflammatory cytokines associated with multiple sclerosis directly induce alterations of neuronal cytoarchitecture in human neurons.
Meyer-Arndt, L. ORCID: https://orcid.org/0000-0002-7909-020X, Kerkering, J. ORCID: https://orcid.org/0000-0002-6432-7104, Kuehl, T., Gil Infante, A., Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070, Rosiewicz, K.S. ORCID: https://orcid.org/0000-0002-6926-7227, Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868 and Alisch, M. ORCID: https://orcid.org/0009-0000-8316-6193
Journal of Neuroimmune Pharmacology 18 (1-2): 145-159. June 2023

Complicated monkeypox infection in a patient with multiple sclerosis and fingolimod treatment.
Müller-Jensen, L. ORCID: https://orcid.org/0000-0002-6388-9375, Kriedemann, H., Anvari, K., Huehnchen, P. and Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868
Neurology 100 (14): 670-671. 4 April 2023

Mepolizumab as an effective treatment in a case of hypophysitis in eosinophilic granulomatosis with polyangiitis.
Chen, J. ORCID: https://orcid.org/0000-0002-4355-4121, Alexander, T., Walter-Rittel, T., Ziagaki, A. and Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868
Therapeutic Advances in Neurological Disorders 16 : 17562864231182519. 2023

2021

Pentafluorosulfanyl (SF(5)) as a superior (19)F magnetic resonance reporter group: signal detection and biological activity of teriflunomide derivatives.
Prinz, C. ORCID: https://orcid.org/0000-0003-3330-031X, Starke, L. ORCID: https://orcid.org/0000-0002-0359-0101, Ramspoth, T.F., Kerkering, J., Martos Riaño, V., Paul, J., Neuenschwander, M. ORCID: https://orcid.org/0000-0002-3114-7975, Oder, A., Radetzki, S. ORCID: https://orcid.org/0000-0003-2688-2868, Adelhoefer, S., Ramos Delgado, P. ORCID: https://orcid.org/0000-0003-2009-3024, Aravina, M. ORCID: https://orcid.org/0000-0002-0970-6080, Millward, J.M. ORCID: https://orcid.org/0000-0003-4484-2798, Fillmer, A., Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070, Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, von Kries, J.P. ORCID: https://orcid.org/0000-0003-4716-4988, Niendorf, T. ORCID: https://orcid.org/0000-0001-7584-6527, Nazaré, M. ORCID: https://orcid.org/0000-0002-1602-2330 and Waiczies, S. ORCID: https://orcid.org/0000-0002-9916-9572
ACS Sensors 6 (11): 3948–3956. 26 November 2021

Lymphocyte access to lymphoma is impaired by high endothelial venule regression.
Menzel, L. ORCID: https://orcid.org/0000-0002-3816-6255, Zschummel, M. ORCID: https://orcid.org/0000-0002-4778-8742, Crowley, T., Franke, V. ORCID: https://orcid.org/0000-0003-3606-6792, Grau, M., Ulbricht, C. ORCID: https://orcid.org/0000-0003-2983-6242, Hauser, A., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Bajénoff, M., Acton, S.E., Akalin, A. ORCID: https://orcid.org/0000-0002-0468-0117, Lenz, G., Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Höpken, U.E. ORCID: https://orcid.org/0000-0002-0776-4893 and Rehm, A. ORCID: https://orcid.org/0000-0001-7490-1950
Cell Reports 37 (4): 109878. 26 October 2021

Identification of the gliogenic state of human neural stem cells to optimize in vitro astrocyte differentiation.
Alisch, M. ORCID: https://orcid.org/0009-0000-8316-6193, Kerkering, J. ORCID: https://orcid.org/0000-0002-6432-7104, Crowley, T., Rosiewicz, K. ORCID: https://orcid.org/0000-0002-6926-7227, Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070 and Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868
Journal of Neuroscience Methods 361 : 109284. 1 September 2021

Epigallocatechin gallate in relapsing-remitting multiple sclerosis: a randomized, placebo-controlled trial.
Bellmann-Strobl, J. ORCID: https://orcid.org/0000-0003-2615-1643, Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070, Wuerfel, J. ORCID: https://orcid.org/0000-0002-0034-8053, Dörr, J., Infante-Duarte, C. ORCID: https://orcid.org/0000-0003-3005-351X, Heidrich, E., Körtgen, B., Brandt, A. ORCID: https://orcid.org/0000-0002-9768-014X, Pfüller, C., Radbruch, H. ORCID: https://orcid.org/0000-0001-6941-3397, Rust, R., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Aktas, O. ORCID: https://orcid.org/0000-0002-2020-9210, Heesen, C., Faiss, J., Hoffmann, F., Lorenz, M., Zimmermann, B., Groppa, S., Wernecke, K.D. and Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928
Neurology Neuroimmunology & Neuroinflammation 8 (3): e981. May 2021

2020

Neutrophil gelatinase-associated lipocalin protects from ANCA-induced GN by inhibiting T(H)17 immunity.
Schreiber, A. ORCID: https://orcid.org/0000-0003-1244-6379, Rousselle, A. ORCID: https://orcid.org/0000-0002-0641-3143, Klocke, J., Bachmann, S., Popovic, S., Bontscho, J., Schmidt-Ott, K.M. ORCID: https://orcid.org/0000-0002-7700-7142, Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Jerke, U., Ashraf, M.I., Panzer, U. and Kettritz, R. ORCID: https://orcid.org/0000-0001-5821-6718
Journal of the American Society of Nephrology 31 (7): 1569-1584. July 2020

Comparison of RNA isolation procedures for analysis of adult murine brain and spinal cord astrocytes.
Rosiewicz, K.S. ORCID: https://orcid.org/0000-0002-6926-7227, Crowley, T., Saher, G., Kerkering, J. ORCID: https://orcid.org/0000-0002-6432-7104, Alisch, M. ORCID: https://orcid.org/0009-0000-8316-6193 and Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868
Journal of Neuroscience Methods 333 : 108545. 1 March 2020

2018

Disease modification in multiple sclerosis by flupirtine - results of a randomized placebo controlled phase II trial.
Dörr, J., Wernecke, K.D., Würfel, J., Bellmann-Strobl, J. ORCID: https://orcid.org/0000-0003-2615-1643, Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Sättler, M.B., Simons, M., Linsa, A., Tumani, H. and Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070
Frontiers in Neurology 9 : 842. October 2018

CCR7 on CD4(+) T cells plays a crucial role in the induction of experimental autoimmune encephalomyelitis.
Belikan, P., Bühler, U., Wolf, C., Pramanik, G.K. ORCID: https://orcid.org/0000-0003-0732-1678, Gollan, R., Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928 and Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868
Journal of Immunology 200 (8): 2554-2562. 15 April 2018

2017

Phenotype of antigen unexperienced T(H) cells in the inflamed central nervous system in experimental autoimmune encephalomyelitis.
Franck, S., Paterka, M., Birkenstock, J., Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928, Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868 and Witsch, E.
Journal of Neuroimmune Pharmacology 12 (2): 305-313. June 2017

Role of IL-17-producing lymphocytes in severity of multiple sclerosis upon natalizumab treatment.
Bühler, U., Fleischer, V., Luessi, F., Rezk, A., Belikan, P., Graetz, C., Gollan, R., Wolf, C., Lutz, J., Bar-Or, A., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868 and Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928
Multiple Sclerosis Journal 23 (4): 567-576. 1 April 2017

Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis.
Paterka, M., Voss, J.O. ORCID: https://orcid.org/0000-0002-1760-2599, Werr, J., Reuter, E., Franck, S., Leuenberger, T., Herz, J., Radbruch, H. ORCID: https://orcid.org/0000-0001-6941-3397, Bopp, T., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868 and Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928
Journal of Autoimmunity 76 : 108-114. January 2017

2016

PML risk stratification using anti-JCV antibody index and L-selectin.
Schwab, N., Schneider-Hohendorf, T., Pignolet, B., Spadaro, M., Görlich, D., Meinl, I., Windhagen, S., Tackenberg, B., Breuer, J., Cantó, E., Kümpfel, T., Hohlfeld, R., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Luessi, F., Posevitz-Fejfár, A., Montalban, X., Meuth, S.G., Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928, Gold, R., Du Pasquier, R.A., Kleinschnitz, C., Jacobi, A., Comabella, M., Bertolotto, A., Brassat, D. and Wiendl, H.
Multiple Sclerosis Journal 22 (8): 1048-1060. July 2016

Flow cytometric analysis of T cell/monocyte ratio in clinically isolated syndrome identifies patients at risk of rapid disease progression.
Nemecek, A., Zimmermann, H., Rübenthaler, J., Fleischer, V., Paterka, M., Luessi, F., Müller-Forell, W., Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928 and Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868
Multiple Sclerosis Journal 22 (4): 483-493. April 2016

In vivo and in vitro effects of multiple sclerosis immunomodulatory therapeutics on glutamatergic excitotoxicity.
Luchtman, D., Gollan, R., Ellwardt, E., Birkenstock, J., Robohm, K., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868 and Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928
Journal of Neurochemistry 136 (5): 971-980. March 2016

Gatekeeper role of brain antigen-presenting CD11c(+) cells in neuroinflammation.
Paterka, M., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Voss, J.O. ORCID: https://orcid.org/0000-0002-1760-2599, Werr, J., Hoppmann, N., Gollan, R., Belikan, P. ORCID: https://orcid.org/0000-0003-0994-1889, Bruttger, J., Birkenstock, J., Jung, S. ORCID: https://orcid.org/0000-0003-4290-5716, Esplugues, E. ORCID: https://orcid.org/0000-0002-8130-0413, Yogev, N., Flavell, R.A., Bopp, T. ORCID: https://orcid.org/0000-0002-3232-8065 and Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928
EMBO Journal 35 (1): 89-101. 4 January 2016

2015

Role of sortilin in models of autoimmune neuroinflammation.
Reuter, E., Weber, J., Paterka, M., Ploen, R., Breiderhoff, T. ORCID: https://orcid.org/0000-0002-1676-7498, van Horssen, J., Willnow, T.E. ORCID: https://orcid.org/0000-0001-9515-7921, Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868 and Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928
Journal of Immunology 195 (12): 5762-5769. 15 December 2015

FRET based ratiometric Ca(2+) imaging to investigate immune-mediated neuronal and axonal damage processes in experimental autoimmune encephalomyelitis.
Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Birkenstock, J., Luchtmann, D.W., Gollan, R., Baumgart, J., Niesner, R.A. ORCID: https://orcid.org/0000-0001-8969-5432, Griesbeck, O. and Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928
Journal of Neuroscience Methods 249 : 8-15. 15 July 2015

New candidates for CD4 T cell pathogenicity in experimental neuroinflammation and multiple sclerosis.
Hoppmann, N., Graetz, C., Paterka, M., Poisa-Beiro, L., Larochelle, C., Hasan, M., Lill, C.M., Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928 and Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868
Brain 138 (Pt 4): 902-917. April 2015

Cross-recognition of a myelin peptide by CD8(+) T cells in the CNS is not sufficient to promote neuronal damage.
Reuter, E., Gollan, R., Grohmann, N., Paterka, M., Salmon, H., Birkenstock, J., Richers, S., Leuenberger, T., Brandt, A.U. ORCID: https://orcid.org/0000-0002-9768-014X, Kuhlmann, T., Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928 and Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868
Journal of Neuroscience 35 (12): 4837-4850. 25 March 2015

MHCII-independent CD4(+) T cells protect injured CNS neurons via IL-4.
Walsh, J.T., Hendrix, S., Boato, F., Smirnov, I., Zheng, J., Lukens, J.R., Gadani, S., Hechler, D., Gölz, G., Rosenberger, K., Kammertöns, T. ORCID: https://orcid.org/0000-0003-3309-5141, Vogt, J., Vogelaar, C., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Radjavi, A., Fernandez-Castaneda, A., Gaultier, A., Gold, R., Kanneganti, T.D., Nitsch, R., Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928 and Kipnis, J.
Journal of Clinical Investigation 125 (2): 699-714. 2 February 2015

The impact of isolated lesions on white-matter fiber tracts in multiple sclerosis patients.
Droby, A., Fleischer, V., Carnini, M., Zimmermann, H., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Gawehn, J., Erb, M., Hildebrandt, A., Baier, B. and Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928
NeuroImage: Clinical 8 : 110-116. 2015

2014

Cardiotoxicity of mitoxantrone treatment in a german cohort of 639 multiple sclerosis patients.
Fleischer, V., Salmen, A., Kollar, S., Weyer, V., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Chan, A., Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928 and Luessi, F.
Journal of Clinical Neurology 10 (4): 289-295. October 2014

Modulation of dendritic cell immunobiology via inhibition of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase.
Leuenberger, T., Pfueller, C.F., Luessi, F., Bendix, I. ORCID: https://orcid.org/0000-0002-9751-3640, Paterka, M., Prozorovski, T., Treue, D., Luenstedt, S., Herz, J., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Infante-Duarte, C. ORCID: https://orcid.org/0000-0003-3005-351X, Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928 and Waiczies, S. ORCID: https://orcid.org/0000-0002-9916-9572
PLoS ONE 9 (7): e100871. 11 July 2014

Experimental applications of TNF-reporter mice with far-red fluorescent label.
Shebzukhov, Y.V., Kuchmiy, A.A., Kruglov, A.A., Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928, Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868 and Nedospasov, S.A.
Methods in Molecular Biology 1155 : 151-162. 10 April 2014

How to treat tumefactive demyelinating disease?
Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Müller-Forell, W., von Pein, H. and Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928
Multiple Sclerosis Journal 20 (5): 631-633. April 2014

Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases.
Langenfurth, A., Rinnenthal, J.L., Vinnakota, K., Prinz, V., Carlo, A.S., Stadelmann, C., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Peaschke, S., Endres, M., Heppner, F., Glass, R., Wolf, S.A. ORCID: https://orcid.org/0000-0003-0922-8418 and Kettenmann, H. ORCID: https://orcid.org/0000-0001-8208-0291
Journal of Neuroscience Research 92 (3): 275-286. March 2014

2013

Microglial activation milieu controls regulatory T cell responses.
Ebner, F., Brandt, C., Thiele, P., Richter, D., Schliesser, U., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Schueler, J., Stubbe, T., Ellinghaus, A., Meisel, C., Sawitzki, B. and Nitsch, R.
Journal of Immunology 191 (11): 5594-5602. 1 December 2013

The role of CD8(+) T cells and their local interaction with CD4(+) T cells in myelin oligodendrocyte glycoprotein(35-55)-induced experimental autoimmune encephalomyelitis.
Leuenberger, T., Paterka, M., Reuter, E., Herz, J., Niesner, R.A. ORCID: https://orcid.org/0000-0001-8969-5432, Radbruch, H. ORCID: https://orcid.org/0000-0001-6941-3397, Bopp, T., Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928 and Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868
Journal of Immunology 191 (10): 4960-4968. 15 November 2013

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

Nature Genetics 45 (11): 1353-1360. November 2013

Parallelized TCSPC for dynamic intravital fluorescence lifetime imaging: quantifying neuronal dysfunction in neuroinflammation.
Rinnenthal, J.L., Börnchen, C., Radbruch, H. ORCID: https://orcid.org/0000-0001-6941-3397, Andresen, V., Mossakowski, A., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Seelemann, T., Spiecker, H., Moll, I., Herz, J., Hauser, A.E., Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928, Behne, M.J. and Niesner, R. ORCID: https://orcid.org/0000-0001-8969-5432
PLoS ONE 8 (4): e60100. 16 April 2013

Modulation of dendritic cell properties by laquinimod as a mechanism for modulating multiple sclerosis.
Jolivel, V., Luessi, F., Masri, J., Kraus, S.H.P., Hubo, M., Poisa-Beiro, L., Klebow, S., Paterka, M., Yogev, N., Tumani, H., Furlan, R., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Jonuleit, H., Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928 and Waisman, A.
Brain 136 (4): 1048-1066. 1 April 2013

Two-photon imaging of immune cells in neural tissue.
Niesner, R. ORCID: https://orcid.org/0000-0001-8969-5432, Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868 and Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928
Cold Spring Harbor Protocols 2013 (3): 224-230. 1 March 2013

2012

Neurodegeneration in multiple sclerosis: novel treatment strategies.
Luessi, F., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868 and Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928
Expert Review of Neurotherapeutics 12 (9): 1061-1077. September 2012

2011

BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions.
Kipp, M., Gingele, S., Pott, F., Clarner, T., van der Valk, P., Denecke, B., Gan, L., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928, Dreher, W., Baumgartner, W., Pfeifenbring, S., Godbout, R., Amor, S. and Beyer, C.
Brain, Behavior and Immunity 25 (8): 1554-1568. November 2011

In vivo imaging of lymphocytes in the CNS reveals different behaviour of naive T cells in health and autoimmunity.
Herz, J., Paterka, M., Niesner, R.A. ORCID: https://orcid.org/0000-0001-8969-5432, Brandt, A.U. ORCID: https://orcid.org/0000-0002-9768-014X, Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Leuenberger, T., Birkenstock, J., Mossakowski, A., Glumm, R., Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928 and Radbruch, H. ORCID: https://orcid.org/0000-0001-6941-3397
Journal of Neuroinflammation 8 (1): 131. 6 October 2011

2010

In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis.
Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Radbruch, H. ORCID: https://orcid.org/0000-0001-6941-3397, Glumm, R., Niesner, R. ORCID: https://orcid.org/0000-0001-8969-5432, Paterka, M., Herz, J., Leuenberger, T., Lehmann, S.M., Luenstedt, S., Rinnenthal, J.L., Laube, G., Luche, H., Lehnardt, S., Fehling, H.J., Griesbeck, O. and Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928
Immunity 33 (3): 424-436. 24 September 2010

Neurodegeneration in autoimmune CNS inflammation.
Herz, J., Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928 and Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868
Experimental Neurology 225 (1): 9-17. September 2010

MAPK3 deficiency drives autoimmunity via dendritic cell arming.
Bendix, I. ORCID: https://orcid.org/0000-0002-9751-3640, Pfueller, C.F., Leuenberger, T., Glezeva, N., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Mueller, Y., Prozorovski, T., Hansen, W., Schulze-Topphoff, U., Loddenkemper, C., Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928 and Waiczies, S. ORCID: https://orcid.org/0000-0002-9916-9572
European Journal of Immunology 40 (5): 1486-1495. May 2010

Multiple sclerosis - candidate mechanisms underlying CNS atrophy.
Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Vogt, J., Radbruch, H. ORCID: https://orcid.org/0000-0001-6941-3397, Nitsch, R. and Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928
Trends in Neurosciences 33 (4): 202-210. April 2010

Expanding two-photon intravital microscopy to the infrared by means of optical parametric oscillator.
Herz, J., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Hauser, A.E., Brandt, A.U. ORCID: https://orcid.org/0000-0002-9768-014X, Leuenberger, T., Radbruch, H. ORCID: https://orcid.org/0000-0001-6941-3397, Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928 and Niesner, R.A. ORCID: https://orcid.org/0000-0001-8969-5432
Biophysical Journal 98 (4): 715-723. 17 February 2010

2009

Cytotoxic CD8+ T cell-neuron interactions: perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell death.
Meuth, S.G., Herrmann, A.M., Simon, O.J., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Melzer, N., Bittner, S., Meuth, P., Langer, H.F., Hallermann, S., Boldakowa, N., Herz, J., Munsch, T., Landgraf, P., Aktas, O. ORCID: https://orcid.org/0000-0002-2020-9210, Heckmann, M., Lessmann, V., Budde, T., Kieseier, B.C., Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928 and Wiendl, H.
Journal of Neuroscience 29 (49): 15397-15409. 9 December 2009

Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system.
Schulze-Topphoff, U., Prat, A., Prozorovski, T., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Paterka, M., Herz, J., Bendix, I. ORCID: https://orcid.org/0000-0002-9751-3640, Ifergan, I., Schadock, I., Mori, M.A., Van Horssen, J., Schroeter, F., Smorodchenko, A., Han, M.H., Bader, M. ORCID: https://orcid.org/0000-0003-4780-4164, Steinman, L., Aktas, O. ORCID: https://orcid.org/0000-0002-2020-9210 and Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928
Nature Medicine 15 (7): 788-793. July 2009

Differential immune cell dynamics in the CNS cause CD4+ T cell compartmentalization.
Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Brandt, A.U. ORCID: https://orcid.org/0000-0002-9768-014X, Radbruch, H. ORCID: https://orcid.org/0000-0001-6941-3397, Herz, J., Boldakowa, N., Leuenberger, T., Werr, J., Hahner, A., Schulze-Topphoff, U., Nitsch, R. and Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928
Brain 132 (5): 1247-1258. May 2009

A new light source for multimodal multiphoton microscopy including CARS.
Rimke, I., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Niesner, R. ORCID: https://orcid.org/0000-0001-8969-5432, Leuenberger, T., Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928, Buttnera, E. and Stibenza, G.
In: Conference on Multiphoton Microscopy in the Biomedical Sciences IX, JAN 25-27, 2009 , San Jose, CA, USA. 13 February 2009

2007

New insights into adaptive immunity in chronic neuroinflammation.
Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Brandt, A.U. ORCID: https://orcid.org/0000-0002-9768-014X, Herz, J. and Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928
Advances in Immunology 96 : 1-40. 2007

2005

Lipopolysaccharide injection induces relapses of experimental autoimmune encephalomyelitis in nontransgenic mice via bystander activation of autoreactive CD4+ cells.
Nogai, A., Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Bonhagen, K., Pfueller, C.F., Hohnstein, T., Volkmer-Engert, R., Brueck, W., Stadelmann, C. and Kamradt, T.
Journal of Immunology 175 (2): 959-966. 15 July 2005