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The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma.
Schleussner, N. and Merkel, O. and Costanza, M. and Liang, H.C. and Hummel, F. and Romagnani, C. and Durek, P. and Anagnostopoulos, I. and Hummel, M. and Jöhrens, K. and Niedobitek, A. and Griffin, P.R. and Piva, R. and Sczakiel, H.L. and Woessmann, W. and Damm-Welk, C. and Hinze, C. and Stoiber, D. and Gillissen, B. and Turner, S.D. and Kaergel, E. and von Hoff, L. and Grau, M. and Lenz, G. and Dörken, B. and Scheidereit, C. and Kenner, L. and Janz, M. and Mathas, S.
Leukemia 32 (9): 1994-2007. September 2018

NF-κB participates in mouse hair cycle control and plays distinct roles in the various pelage hair follicle types.
Krieger, K. and Millar, S.E. and Mikuda, N. and Krahn, I. and Kloepper, J.E. and Bertolini, M. and Scheidereit, C. and Paus, R. and Schmidt-Ullrich, R.
Journal of Investigative Dermatology 138 (2): 256-264. February 2018


Endothelial NF-κB blockade abrogates ANCA-induced GN.
Choi, M. and Schreiber, A. and Eulenberg-Gustavus, C. and Scheidereit, C. and Kamps, J. and Kettritz, R.
Journal of the American Society of Nephrology 28 (11): 3191-3204. November 2017

NF-κB activation protects oligodendrocytes against inflammation.
Stone, S. and Jamison, S. and Yue, Y. and Durose, W. and Schmidt-Ullrich, R. and Lin, W.
Journal of Neuroscience 37 (38): 9332-9344. 20 September 2017

Central immune tolerance depends on crosstalk between the classical and alternative NF-κB pathways in medullary thymic epithelial cells.
Riemann, M. and Andreas, N. and Fedoseeva, M. and Meier, E. and Weih, D. and Freytag, H. and Schmidt-Ullrich, R. and Klein, U. and Wang, Z.Q. and Weih, F.
Journal of Autoimmunity 81 : 56-67. July 2017


ANCA-associated vasculitis and the mechanisms of tissue injury.
Schreiber, A. and Choi, M.
In: Systemic Vasculitides: Current Status and Perspectives. Springer International Publishing, Switzerland, 141-158. ISBN 978-3-319-40134-8 14 October 2016

Regional regulation of filiform tongue papillae development by Ikkα/Irf6.
Kawasaki, M. and Kawasaki, K. and Oommen, S. and Blackburn, J. and Watanabe, M. and Nagai, T. and Kitamura, A. and Maeda, T. and Liu, B. and Schmidt-Ullrich, R. and Akiyama, T. and Inoue, J.I. and Hammond, N.L. and Sharpe, P.T. and Ohazama, A.
Developmental Dynamics 245 (9): 937-946. September 2016

Tubular epithelial NF-κB activity regulates ischemic AKI.
Markó, L. and Vigolo, E. and Hinze, C. and Park, J.K. and Roël, G. and Balogh, A. and Choi, M. and Wübken, A. and Cording, J. and Blasig, I.E. and Luft, F.C. and Scheidereit, C. and Schmidt-Ott, K.M. and Schmidt-Ullrich, R. and Müller, D.N.
Journal of the American Society of Nephrology 27 (9): 2658-2669. September 2016

LHX2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth.
Tomann, P. and Paus, R. and Millar, S.E. and Scheidereit, C. and Schmidt-Ullrich, R.
Development 143 (9): 1512-1522. 1 May 2016

A roadmap of constitutive NF-κB activity in Hodgkin lymphoma: dominant roles of p50 and p52 revealed by genome-wide analyses.
de Oliveira, K.A.P. and Kaergel, E. and Heinig, M. and Fontaine, J.F. and Patone, G. and Muro, E.M. and Mathas, S. and Hummel, M. and Andrade-Navarro, M.A. and Hübner, N. and Scheidereit, C.
Genome Medicine 8 (1): 28. 17 March 2016


Ectodysplasin/NF-κB promotes mammary cell fate via Wnt/β-catenin pathway.
Voutilainen, M. and Lindfors, P.H. and Trela, E. and Loennblad, D. and Shirokova, V. and Elo, T. and Rysti, E. and Schmidt-Ullrich, R. and Schneider, P. and Mikkola, M.L.
PLoS Genetics 11 (11): e1005676. 18 November 2015

Potent anti-tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma.
Oden, F. and Marino, S.F. and Brand, J. and Scheu, S. and Kriegel, C. and Olal, D. and Takvorian, A. and Westermann, J. and Yilmaz, B. and Hinz, M. and Daumke, O. and Höpken, U.E. and Müller, G. and Lipp, M.
Molecular Oncology 9 (7): 1348-1358. August 2015

RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.
Murakawa, Y. and Hinz, M. and Mothes, J. and Schuetz, A. and Uhl, M. and Wyler, E. and Yasuda, T. and Mastrobuoni, G. and Friedel, C.C. and Dölken, L. and Kempa, S. and Schmidt-Supprian, M. and Blüthgen, N. and Backofen, R. and Heinemann, U. and Wolf, J. and Scheidereit, C. and Landthaler, M.
Nature Communications 6 : 7367. 14 July 2015

ROCK-isoform-specific polarization of macrophages associated with age-related macular degeneration.
Zandi, S. and Nakao, S. and Chun, K.H. and Fiorina, P. and Sun, D. and Arita, R. and Zhao, M. and Kim, E. and Schueller, O. and Campbell, S. and Taher, M. and Melhorn, M.I. and Schering, A. and Gatti, F. and Tezza, S. and Xie, F. and Vergani, A. and Yoshida, S. and Ishikawa, K. and Yamaguchi, M. and Sasaki, F. and Schmidt-Ullrich, R. and Hata, Y. and Enaida, H. and Yuzawa, M. and Yokomizo, T. and Kim, Y.B. and Sweetnam, P. and Ishibashi, T. and Hafezi-Moghadam, A.
Cell Reports 10 (7): 1173-1186. 24 February 2015

Excess NF-κB induces ectopic odontogenesis in embryonic incisor epithelium.
Blackburn, J. and Kawasaki, K. and Porntaveetus, T. and Kawasaki, M. and Otsuka-Tanaka, Y. and Miake, Y. and Ota, M.S. and Watanabe, M. and Hishinuma, M. and Nomoto, T. and Oommen, S. and Ghafoor, S. and Harada, F. and Nozawa-Inoue, K. and Maeda, T. and Peterkova, R. and Lesot, H. and Inoue, J. and Akiyama, T. and Schmidt-Ullrich, R. and Liu, B. and Hu, Y. and Page, A. and Ramirez, A. and Sharpe, P.T. and Ohazama, A.
Journal of Dental Research 94 (1): 121-128. January 2015


Quantitative dissection and modeling of the NF-κB p100-p105 module reveals interdependent precursor proteolysis.
Yilmaz, Z.B. and Kofahl, B. and Beaudette, P. and Baum, K. and Ipenberg, I. and Weih, F. and Wolf, J. and Dittmar, G. and Scheidereit, C.
Cell Reports 9 (5): 1756-1769. 11 December 2014

Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma.
Kreher, S. and Bouhlel, M.A. and Cauchy, P. and Lamprecht, B. and Li, S. and Grau, M. and Hummel, F. and Köchert, K. and Anagnostopoulos, I. and Jöhrens, K. and Hummel, M. and Hiscott, J. and Wenzel, S.S. and Lenz, P. and Schneider, M. and Küppers, R. and Scheidereit, C. and Giefing, M. and Siebert, R. and Rajewsky, K. and Lenz, G. and Cockerill, P.N. and Janz, M. and Dörken, B. and Bonifer, C. and Mathas, S.
Proceedings of the National Academy of Sciences of the United States of America 111 (42): E4513-E4522. 21 October 2014

NF-κB activity is required for anagen maintenance in human hair follicles in vitro.
Kloepper, J.E. and Ernst, N. and Krieger, K. and Bodo, E. and Biro, T. and Haslam, I.S. and Schmidt-Ullrich, R. and Paus, R.
Journal of Investigative Dermatology 134 (7): 2036-2038. 11 February 2014

The IκB kinase complex in NF-κB regulation and beyond.
Hinz, M. and Scheidereit, C.
EMBO Reports 15 (1): 46-61. 1 January 2014


IκB-ζ controls the constitutive NF-κB target gene network and survival of ABC DLBCL.
Nogai, H. and Wenzel, S.S. and Hailfinger, S. and Grau, M. and Kaergel, E. and Seitz, V. and Wollert-Wulf, B. and Pfeifer, M. and Wolf, A. and Frick, M. and Dietze, K. and Madle, H. and Tzankov, A. and Hummel, M. and Dörken, B. and Scheidereit, C. and Janz, M. and Lenz, P. and Thome, M. and Lenz, G.
Blood 122 (13): 2242-2250. 26 September 2013

Novel signalling mechanisms and targets in renal ischaemia and reperfusion injury.
Kusch, A. and Hoff, U. and Bubalo, G. and Zhu, Y. and Fechner, M. and Schmidt-Ullrich, R. and Marko, L. and Müller, D.N. and Schmidt-Ott, K.M. and Guergen, D. and Blum, M. and Schunck, W.H. and Dragun, D.
Acta Physiologica 208 (1): 25-40. May 2013

Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: an update.
Nakamura, M. and Schneider, M.R. and Schmidt-Ullrich, R. and Paus, R.
Journal of Dermatological Science 69 (1): 6-29. January 2013


An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration.
Lehmann, S.M. and Krueger, C. and Park, B. and Derkow, K. and Rosenberger, K. and Baumgart, J. and Trimbuch, T. and Eom, G. and Hinz, M. and Kaul, D. and Habbel, P. and Kaelin, R. and Franzoni, E. and Rybak, A. and Nguyen, D. and Veh, R. and Ninnemann, O. and Peters, O. and Nitsch, R. and Heppner, F.L. and Golenbock, D. and Schott, E. and Ploegh, H.L. and Wulczyn, F.G. and Lehnardt, S.
Nature Neuroscience 15 (6): 827-835. June 2012

The role of Irf6 in tooth epithelial invagination.
Blackburn, J. and Ohazama, A. and Kawasaki, K. and Otsuka-Tanaka, Y. and Liu, B. and Honda, K. and Rountree, R.B. and Hu, Y. and Kawasaki, M. and Birchmeier, W. and Schmidt-Ullrich, R. and Kinoshita, A. and Schutte, B.C. and Hammond, N.L. and Dixon, M.J. and Sharpe, P.T.
Developmental Biology 365 (1): 61-70. 1 May 2012

Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-κB.
Voutilainen, M. and Lindfors, P.H. and Lefebvre, S. and Ahtiainen, L. and Fliniaux, I. and Rysti, E. and Murtoniemi, M. and Schneider, P. and Schmidt-Ullrich, R. and Mikkola, M.L.
Proceedings of the National Academy of Sciences of the United States of America 109 (15): 5744-5749. 10 April 2012

It takes two to tango: IκBs, the multifunctional partners of NF-κB.
Hinz, M. and Coel Arslan, S. and Scheidereit, C.
Immunological Reviews 246 (1): 59-76. March 2012


Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations.
Jing, H. and Kase, J. and Doerr, J.R. and Milanovic, M. and Lenze, D. and Grau, M. and Beuster, G. and Ji, S. and Reimann, M. and Lenz, P. and Hummel, M. and Doerken, B. and Lenz, G. and Scheidereit, C. and Schmitt, C.A. and Lee, S.
Genes & Development 25 (20): 2137-2146. 15 October 2011

The prevalence of TNFα-induced necrosis over apoptosis is determined by TAK1-RIP1 interplay.
Coel Arslan, S. and Scheidereit, C.
PLoS ONE 6 (10): e26069. 10 October 2011

Ectodysplasin and Wnt pathways are required for salivary gland branching morphogenesis.
Haeaerae, O. and Fujimori, S. and Schmidt-Ullrich, R. and Hartmann, C. and Thesleff, I. and Mikkola, M.L.
Development 138 (13): 2681-2691. July 2011


A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation.
Hinz, M. and Stilmann, M. and Coel Arslan, S. and Khanna, K.K. and Dittmar, G. and Scheidereit, C.
Molecular Cell 40 (1): 63-74. 8 October 2010

Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor.
Rauch, A. and Seitz, S. and Baschant, U. and Schilling, A.F. and Illing, A. and Stride, B. and Kirilov, M. and Mandic, V. and Takacz, A. and Schmidt-Ullrich, R. and Ostermay, S. and Schinke, T. and Spanbroek, R. and Zaiss, M.M. and Angel, P.E. and Lerner, U.H. and David, J.P. and Reichardt, H.M. and Amling, M. and Schuetz, G. and Tuckermann, J.P.
Cell Metabolism 11 (6): 517-531. 9 June 2010


Identification of a chemokine receptor profile characteristic for mediastinal large B-cell lymphoma.
Rehm, A. and Anagnostopoulos, I. and Gerlach, K. and Broemer, M. and Scheidereit, C. and Joehrens, K. and Huebler, M. and Hetzer, R. and Stein, H. and Lipp, M. and Doerken, B. and Hoepken, U.E.
International Journal of Cancer 125 (10): 2367-2374. 15 November 2009

A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IκB kinase activation.
Stilmann, M. and Hinz, M. and Coel Arslan, S. and Zimmer, A. and Schreiber, V. and Scheidereit, C.
Molecular Cell 36 (3): 365-378. 13 November 2009

Reciprocal requirements for EDA/EDAR/NF-κB and Wnt/β-catenin signaling pathways in hair follicle induction.
Zhang, Y. and Tomann, P. and Andl, T. and Gallant, N.M. and Huelsken, J. and Jerchow, B. and Birchmeier, W. and Paus, R. and Piccolo, S. and Mikkola, M.L. and Morrisey, E.E. and Overbeek, P.A. and Scheidereit, C. and Millar, S.E. and Schmidt-Ullrich, R.
Developmental Cell 17 (1): 49-61. 21 July 2009

The hair follicle as a dynamic miniorgan.
Schneider, M.R. and Schmidt-Ullrich, R. and Paus, R.
Current Biology 19 (3): R132-T142. 10 February 2009

Lef1 plays a role in patterning the mesoderm and ectoderm in Xenopus tropicalis.
Roel, G. and Gent, Y.Y. and Peterson-Maduro, J. and Verbeek, F.J. and Destree, O.
International Journal of Developmental Biology 53 (1): 81-89. 2009


Differential RelA- and RelB-dependent gene transcription in LTbetaR-stimulated mouse embryonic fibroblasts.
Lovas, A. and Radke, D. and Albrecht, D. and Yilmaz, Z.B. and Moeller, U. and Habenicht, A.J. and Weih, F.
BMC Genomics 9 : 606. 16 December 2008

Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate.
Zhang, Y. and Andl, T. and Yang, S.H. and Teta, M. and Liu, F. and Seykora, J.T. and Tobias, J.W. and Piccolo, S. and Schmidt-Ullrich, R. and Nagy, A. and Taketo, M.M. and Dlugosz, A.A. and Millar, S.E.
Development 135 (12): 2161-2172. June 2008

Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis.
Liu, F. and Chu, E.Y. and Watt, B. and Zhang, Y. and Gallant, N.M. and Andl, T. and Yang, S.H. and Lu, M.M. and Piccolo, S. and Schmidt-Ullrich, R. and Taketo, M.M. and Morrisey, E.E. and Atit, R. and Dlugosz, A.A. and Millar, S.E.
Developmental Biology 313 (1): 210-224. 1 January 2008


Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation.
Oeckinghaus, A. and Wegener, E. and Welteke, V. and Ferch, U. and Coel Arslan, S. and Ruland, J. and Scheidereit, C. and Krappmann, D.
EMBO Journal 26 (22): 4634-4645. 14 November 2007

Signal-responsiveness of Ikappa B kinases is determined by Cdc37-assisted transient interaction with Hsp90.
Hinz, M. and Broemer, M. and Coel Arslan, S. and Otto, A. and Mueller, E.C. and Dettmer, R. and Scheidereit, C.
Journal of Biological Chemistry 282 (44): 32311-32319. 2 November 2007

High expression of RelA/p65 is associated with activation of nuclear factor-kappaB-dependent signaling in pancreatic cancer and marks a patient population with poor prognosis.
Weichert, W. and Boehm, M. and Gekeler, V. and Bahra, M. and Langrehr, J. and Neuhaus, P. and Denkert, C. and Imre, G. and Weller, C. and Hofmann, H.P. and Niesporek, S. and Jacob, J. and Dietel, M. and Scheidereit, C. and Kristiansen, G.
British Journal of Cancer 97 : 523-530. 14 August 2007

Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage.
Henke, N. and Schmidt-Ullrich, R. and Dechend, R. and Park, J.K. and Qadri, F. and Wellner, M. and Obst, M. and Gross, V. and Dietz, R. and Luft, F.C. and Scheidereit, C. and Mueller, D.N.
Circulation Research 101 (3): 268-276. 3 August 2007

Striking back at the activator: how IkappaB kinase terminates antigen receptor responses.
Hinz, M. and Scheidereit, C.
Science's STKE Signal Transduction Knowledge Environment 384 : pe19. 1 May 2007


Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis.
Visekruna, A. and Joeris, T. and Seidel, D. and Kroesen, A. and Loddenkemper, C. and Zeitz, M. and Kaufmann, S.H.E. and Schmidt-Ullrich, R. and Steinhoff, U.
Journal of Clinical Investigation 116 (12): 3195-3203. December 2006

IkappaB kinase complexes: gateways to NF-kappaB activation and transcription.
Scheidereit, C.
Oncogene 25 (51): 6685-6705. 30 October 2006

Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation.
Wegener, E. and Oeckinghaus, A. and Papadopoulou, N. and Lavitas, L. and Schmidt-Supprian, M. and Ferch, U. and Mak, T.W. and Ruland, J. and Heissmeyer, V. and Krappmann, D.
Molecular Cell 23 (1): 13-23. 7 July 2006

Modulierung der NF-kappaB-Aktivitaet in T-Zellen durch den Carmal1-Bcl10-Malt1 Komplex.
Wegener, E.

NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth.
Schmidt-Ullrich, R. and Tobin, D.J. and Lenhard, D. and Schneider, P. and Paus, R. and Scheidereit, C.
Development 133 (6): 1045-1057. 15 March 2006

NF-κB pathway.
Scheidereit, C. and Krappmann, D.
In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2. Springer, Berlin [u.a.], 1286-1292. ISBN 3-540-44244-8 2006


Viral targeting of the interferon-beta-inducing Traf family member-associated NF-kappaB activator (TANK)-binding kinase-1.
Unterstab, G. and Ludwig, S. and Anton, A. and Planz, O. and Dauber, B. and Krappmann, D. and Heins, G. and Ehrhardt, C. and Wolff, T.
Proceedings of the National Academy of Sciences of the United States of America 102 (38): 13640-13645. 9 September 2005

Elevated NF-kappaB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large cell, and other peripheral T-cell lymphomas.
Mathas, S. and Joehrens, K. and Joos, S. and Lietz, A. and Hummel, F. and Janz, M. and Jundt, F. and Anagnostopoulos, I. and Bommert, K. and Lichter, P. and Stein, H. and Scheidereit, C. and Doerken, B.
Blood 106 (13): 4287-4293. 25 August 2005

Molecular principles of hair follicle induction and morphogenesis.
Schmidt-Ullrich, R. and Paus, R.
BioEssays 27 (3): 247-261. 15 February 2005

A pervasive role of ubiquitin conjugation in activation and termination of IkappaB kinase pathways.
Krappmann, D. and Scheidereit, C.
EMBO Reports 6 (4): 321-326. 1 January 2005

Regulation of vascular smooth muscle cell proliferation. Role of NF-kappaB revisited.
Mehrhof, F.B. and Schmidt-Ullrich, R. and Dietz, R. and Scheidereit, C.
Circulation Research 96 (9): 958-964. 1 January 2005

Requirement of nuclear factor-kappaB in angiotensin II- and isoproterenol-induced cardiac hypertrophy in vivo.
Freund, C. and Schmidt-Ullrich, R. and Baurand, A. and Dunger, S. and Schneider, W. and Loser, P. and El-Jamali, A. and Dietz, R. and Scheidereit, C. and Bergmann, M.W.
Circulation 111 (18): 2319-2325. 1 January 2005

The effect of fever-like temperatures on neutrophil signaling.
Salanova, B. and Choi, M. and Rolle, S. and Wellner, M. and Scheidereit, C. and Luft, F.C. and Kettritz, R.
FASEB Journal 19 (7): 816-818. 1 January 2005


Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation.
Broemer, M. and Krappmann, D. and Scheidereit, C.
Oncogene 23 (31): 5378-5386. 8 July 2004

The IκB kinase complex and NF-κB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1.
Krappmann, D. and Wegener, E. and Sunami, Y. and Esen, M. and Thiel, A. and Mordmueller, B. and Scheidereit, C.
Molecular and Cellular Biology 24 (14): 6488-6500. 1 July 2004

Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappaB signaling.
Scharschmidt, E. and Wegener, E. and Heissmeyer, V. and Rao, A. and Krappmann, D.
Molecular and Cellular Biology 24 (9): 3860-3873. 1 May 2004

A dual role for lkkalpha in tooth development.
Ohazama, A. and Hu, Y.L. and Schmidt-Ullrich, R. and Cao, Y.X. and Scheidereit, C. and Karin, M. and Sharpe, P.T.
Developmental Cell 6 (2): 219-227. 1 January 2004

Reoxygenation after severe hypoxia induces cardiomyocyte hypertrophy in vitro: activation of CREB downstream of GSK3beta.
El Jamali, A. and Freund, C. and Rechner, C. and Scheidereit, C. and Dietz, R. and Bergmann, M.W.
FASEB Journal 18 (10): 1096-1098. 1 January 2004


Inhibition of NF-κ B by a TAT-NEMO-binding domain peptide accelerates constitutive apoptosis and abrogates LPS-delayed neutrophil apoptosis.
Choi, M. and Rolle, S. and Wellner, M. and Cardoso, M.C. and Scheidereit, C. and Luft, F.C. and Kettritz, R.
Blood 102 (6): 2259-2267. 15 September 2003

Inhibition of NF-κB essentially contributes to arsenic-induced apoptosis.
Mathas, S. and Lietz, A. and Janz, M. and Hinz, M. and Jundt, F. and Scheidereit, C. and Bommert, K. and Doerken, B.
Blood 102 (3): 1028-1034. 1 August 2003

Tetrameric oligomerization of I kappa B kinase gamma (IKK gamma) is obligatory for IKK complex activity and NF-kappa B activation.
Tegethoff, S. and Behlke, J. and Scheidereit, C.
Molecular and Cellular Biology 23 (6): 2029-2041. March 2003

Lymphotoxin and lipopolysaccharide induce NF-κB-p52 generation by a co-translational mechanism.
Mordmueller, B. and Krappmann, D. and Esen, M. and Wegener, E. and Scheidereit, C.
EMBO Reports 4 (1): 82-87. 1 January 2003

The pathogenetic significance of deregulated signal transduction pathways in Hodgkin's disease: the NF-kappaB-AP-1 network.
Scheidereit, C.
Verhandlungen der Deutschen Gesellschaft fuer Pathologie 87 : 79-89. 1 January 2003


Nuclear factor κB-dependent gene expression profiling of Hodgkins disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity.
Hinz, M. and Lemke, P. and Anagnostopoulos, I. and Hacker, C. and Krappmann, D. and Mathas, S. and Doerken, B. and Zenke, M. and Stein, H. and Scheidereit, C.
Journal of Experimental Medicine 196 (5): 605-617. 2 September 2002

Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.
Mathas, S. and Hinz, M. and Anagnostopoulos, L. and Krappmann, D. and Lietz, A. and Jundt, F. and Bommert, K. and Mechta-Grigoriou, F. and Stein, H. and Doerken, B. and Scheidereit, C.
EMBO Journal 21 (15): 4104-4113. 1 August 2002

Activation of cyclin D1 and D2 promoters by human T-cell leukemia virus type I tax protein is associated with IL-2-independent growth of T cells.
Mori, N. and Fujii, M. and Hinz, M. and Nakayama, K. and Yamada, Y. and Ikeda, S. and Yamasaki, Y. and Kashanchi, F. and Tanaka, Y. and Tomonaga, M. and Yamamoto, N.
International Journal of Cancer 99 (3): 378-385. 20 May 2002

Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease.
Jundt, F. and Kley, K. and Anagnostopoulos, I. and Schulze-Proebsting, K. and Greiner, A. and Mathas, S. and Scheidereit, C. and Wirth, T. and Stein, H. and Doerken, B.
Blood 99 (8): 3060-3062. 15 April 2002

Genetisch veraendertes, nicht-menschliches Saeugetier, das ein zusaetzliches induzierbares Regulator-Gen enthaelt [Genetically modified, non-human mammal containing an additional inducible regulator gene].
Scheidereit, C. and Schmidt-Ullrich, R.
DE10041842A1 ; WO0216573. 7 March 2002

Purification and characterization of the human Elongator complex.
Hawkes, N.A. and Otero, G. and Winkler, G.S. and Marshall, N. and Dahmus, M.E. and Krappmann, D. and Scheidereit, C. and Thomas, C.L. and Schiavo, G. and Erdjument-Bromage, H. and Tempst, P. and Svejstrup, J.Q.
Journal of Biological Chemistry 277 (4): 3047-3052. 1 January 2002

Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs.
Hoepken, U.E. and Foss, H.D. and Meyer, D. and Hinz, M. and Leder, K. and Stein, H. and Lipp, M.
Blood 99 (4): 1109-1116. 1 January 2002


Nitric oxide synthase 2Lambarene (G-954C), increased nitric oxide production, and protection against malaria.
Kun, J.F. and Mordmueller, B. and Perkins, D.J. and May, J. and Mercereau-Puijalon, O. and Alpers, M. and Weinberg, J.B. and Kremsner, P.G.
Journal of Infectious Diseases 184 (3): 330-336. 1 August 2001

The MAPK kinase kinase TAK1 plays a central role in coupling the interleukin-1 receptor to both transcriptional and RNA-targeted mechanisms of gene regulation.
Holtmann, H. and Enninga, J. and Kalble, S. and Thiefes, A. and Dorrie, A. and Broemer, M. and Winzen, R. and Wilhelm, A. and Ninomiya-Tsuji, J. and Matsumoto, K. and Resch, K. and Kracht, M.
Journal of Biological Chemistry 276 : 3508-3516. 2 February 2001

Aspirin inhibits NF-kappa B and protects from angiotensin II-induced organ damage.
Mueller, D.N. and Heissmeyer, V. and Dechend, R. and Hampich, F. and Park, J.K. and Fiebeler, A. and Shagdarsuren, E. and Theuer, J. and Elger, M. and Pilz, B. and Breu, V. and Schroer, K. and Ganten, D. and Dietz, R. and Haller, H. and Scheidereit, C. and Luft, F.C.
FASEB Journal 15 : 1822-1824. 1 January 2001

B-cell receptor- and phorbol ester-induced NF-kappa B and c-Jun N-terminal kinase activation in B cells requires novel protein kinase C's.
Krappmann, D. and Patke, A. and Heissmeyer, V. and Scheidereit, C.
Molecular and Cellular Biology 21 : 6640-6650. 1 January 2001

Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.
Hinz, M. and Loeser, P. and Mathas, S. and Krappmann, D. and Doerken, B. and Scheidereit, C.
Blood 97 (9): 2798-2807. 1 January 2001

In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein.
Mehrhof, F.B. and Mueller, F.U. and Bergmann, M.W. and Li, P.F. and Wang, Y.B. and Schmitz, W. and Dietz, R. and von Harsdorf, R.
Circulation 104 : 2088-2094. 1 January 2001

In vitro susceptibility to TRAIL-induced apoptosis of acute leukemia cells in the context of TRAIL receptor gene expression and constitutive NF-kappaB activity.
Wuchter, C. and Krappmann, D. and Cai, Z. and Ruppert, V. and Scheidereit, C. and Doerken, B. and Ludwig, W.D. and Karawajew, L.
Leukemia 15 (6): 921-928. 1 January 2001

Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices.
Schmidt-Ullrich, R. and Aebischer, T. and Huelsken, J. and Birchmeier, W. and Klemm, U. and Scheidereit, C.
Development 128 (19): 3843-3853. 1 January 2001

Shared pathways of IkappaB kinase-induced SCF betaTrCP-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and I kappa B alpha.
Heissmeyer, V. and Krappmann, D. and Hatada, E.N. and Scheidereit, C.
Molecular and Cellular Biology 21 (4): 1024-1035. 1 January 2001

Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia.
Slaugenhaupt, S.A. and Blumenfeld, A. and Gill, S.P. and Leyne, M. and Mull, J. and Cuajungco, M.P. and Liebert, C.B. and Chadwick, B. and Idelson, M. and Reznik, L. and Robbins, C.M. and Makalowska, I. and Brownstein, M.J. and Krappmann, D. and Scheidereit, C. and Maayan, C. and Axelrod, F.B. and Gusella, J.F.
American Journal of Human Genetics 68 : 598-605. 1 January 2001


Promoter variants of the human mannose-binding lectin gene show different binding.
Jueliger, S. and Luckner, D. and Mordmueller, B. and May, J. and Weierich, A. and Lell, B. and Luty, A. and Kremsner, P.G. and Kun, J.F.
Biochemical and Biophysical Research Communications 275 : 617-622. 28 August 2000

In vivo identification of lymphocyte subsets exhibiting transcriptionally active NF-kappaB/Rel complexes.
Feuillard, J. and Memet, S. and Goudeau, B. and Lilienbaum, A. and Schmidt-Ullrich, R. and Raphael, M. and Israel, A.
International Immunology 12 (5): 613-621. May 2000

Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex.
Hehner, S.P. and Hofmann, T.G. and Ushmorov, A. and Dienz, O. and Leung, I.W.L. and Lassam, N. and Scheidereit, C. and Droege, W. and Schmitz, M.L.
Molecular and Cellular Biology 20 : 2556-2568. 1 April 2000

Cutaneous inflammation and proliferation in vitro: Differential effects and mode of action of topical glucocorticoids.
Lange, K. and Kleuser, B. and Gysler, A. and Bader, M. and Maia, C. and Scheidereit, C. and Korting, H.C. and Schaefer-Korting, M.
Skin Pharmacology and Applied Skin Physiology 13 (2): 93-103. 1 March 2000

Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells.
Kordes, U. and Krappmann, D. and Heissmeyer, V. and Ludwig, W.D. and Scheidereit, C.
Leukemia 14 (3): 399-402. March 2000

NF-kappaB and the innate immune response.
Hatada, E.N. and Krappmann, D. and Scheidereit, C.
Current Opinion in Immunology 12 : 52-58. 1 February 2000

Anti-CD20-and B-cell receptor-mediated apoptosis: Evidence for shared intracellular signaling pathways.
Mathas, S. and Rickers, A. and Bommert, K. and Doerken, B. and Mapara, M.Y.
Cancer Research 60 (24): 7170-7176. 1 January 2000

Interaction and functional interference of C/EBPbeta with octamer factors in immunoglobulin gene transcription.
Hatada, E.N. and Chen-Kiang, S. and Scheidereit, C.
European Journal of Immunology 30 (1): 174-184. 1 January 2000

The IkappaB kinase (IKK) complex is tripartiteand contains IKKgamma but not IKAP as a regular component.
Krappmann, D. and Hatada, E.N. and Tegethoff, S. and Li, J. and Klippel, A. and Giesel, K. and Baeuerle, A. and Scheidereit, C.
Journal of Biological Chemistry 275 : 29779-29787. 1 January 2000


Overexpression of IkappaBalpha without inhibition of NF-kappaB activity and mutations in the IkappaBalpha gene in Reed-Sternberg cells.
Emmerich, F. and Meiser, M. and Hummel, M. and Demel, G. and Foss, H.D. and Jundt, F. and Mathas, S. and Krappmann, D. and Scheidereit, C. and Stein, H. and Doerken, B.
Blood 94 : 3129-3134. 1 November 1999

Chlamydia pneumoniae infection of vascular smooth muscle and endothelial cells activates NF-kappaB and induces tissue factor and PAI-1 expression - A potential link to accelerated arteriosclerosis.
Dechend, R. and Maass, M. and Gieffers, J. and Dietz, R. and Scheidereit, C. and Leutz, A. and Gulba, D.C.
Circulation 100 : 1369-1373. 28 September 1999

NF-kappaB p105 is a target of I kappaB kinases and controls signal induction of Bcl-3-p50 complexes.
Heissmeyer, V. and Krappmann, D. and Wulczyn, F.G. and Scheidereit, C.
EMBO Journal 18 : 4766-4778. 1 September 1999

E2F-1 overexpression in cardiomyocytes induces downregulation of p21CIP1 and p27KIP1 and release of active cyclin-dependent kinases in the presence of insulin-like growth factor I.
von Harsdorf, R. and Hauck, L. and Mehrhof, F. and Wegenka, U. and Cardoso, M.C. and Dietz, R.
Circulation Research 85 : 128-136. 23 July 1999

The Bcl-3 oncoprotein acts as a bridging factor between NF-kappa B/Rel and nuclear co-regulators.
Dechend, R. and Hirano, F. and Lehmann, K. and Heissmeyer, V. and Ansieau, S. and Wulczyn, F.G. and Scheidereit, C. and Leutz, A.
Oncogene 18 : 3316-3323. 3 June 1999

NF-kappaB function in growth control: Regulation of cyclin D1 expression and G(0)G(1)-to-S-Phase transition.
Hinz, M. and Krappmann, D. and Eichten, A. and Heder, A. and Scheidereit, C. and Strauss, M.
Molecular and Cellular Biology 19 : 2690-2698. 1 April 1999

Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells.
Krappmann, D. and Emmerich, F. and Kordes, U. and Scharschmidt, E. and Doerken, B. and Scheidereit, C.
Oncogene 18 : 943-953. 28 January 1999


Signal transduction. Docking IkappaB kinases.
Scheidereit, C.
Nature 395 : 225-226. 17 September 1998

Neutrophils and monocytes from subjects with the Mediterranean G6PD variant: effect of Plasmodium falciparum hemozoin on G6PD activity, oxidative burst and cytokine production.
Mordmueller, B. and Turrini, F. and Long, H. and Kremsner, P.G. and Arese, P.
European Cytokine Network 9 : 239-245. 1 September 1998

Alternative splicing variants of IkappaBbeta establish differential NF-kappaB signal responsiveness in human cells.
Hirano, F. and Chung, M.R. and Tanaka, H. and Maruyama, N. and Makino, I. and Moore, D.D. and Scheidereit, C.
Molecular and Cellular Biology 18 (5): 2596-2607. May 1998

Hyperparasitemia and blood exchange transfusion for treatment of children with falciparum malaria.
Mordmueller, B. and Kremsner, P.G.
Clinical Infectious Diseases 26 : 850-852. 1 April 1998

Signal-dependent degradation of IkappaBalpha is mediated by an inducible destruction box that can be transferred to NF-kappaB, bcl-3 or p53.
Wulczyn, F.G. and Krappmann, D. and Scheidereit, C.
Nucleic Acids Research 26 (7): 1724-1730. 1 April 1998

Inhibition of NF-kappaB-dependent transcription of human immunodeficiency virus 1 promoter by a phosphodiester compound of vitamin C and vitamin E, EPC-K1.
Hirano, F. and Tanaka, H. and Miura, T. and Hirano, Y. and Okamoto, K. and Makino, Y. and Makino, I.
Immunopharmacology 39 : 31-38. 1 March 1998

Functional interference of Sp1 and NF-kappaB through the same DNA binding site.
Hirano, F. and Tanaka, H. and Hirano, Y. and Hiramoto, M. and Handa, H. and Makino, I. and Scheidereit, C.
Molecular and Cellular Biology 18 (3): 1266-1274. March 1998

Polymorphism in promoter region of inducible nitric oxide synthase gene and protection against malaria.
Kun, J.F. and Mordmueller, B. and Lell, B. and Lehman, L.G. and Luckner, D. and Kremsner, P.G.
Lancet 351 (9098): 265-266. 24 January 1998


Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.
Bargou, R.C. and Emmerich, F. and Krappmann, D. and Bommert, K. and Mapara, M.Y. and Arnold, W. and Royer, H.D. and Grinstein, E. and Greiner, A. and Scheidereit, C. and Doerken, B.
Journal of Clinical Investigation 100 (12): 2961-2969. 15 December 1997

Efficient transcription of an immunoglobulin kappa promoter requires specific sequence elements overlapping with and downstream of the transcriptional start site.
Pelletier, M.R. and Hatada, E.N. and Scholz, G. and Scheidereit, C.
Nucleic Acids Research 25 (20): 3995-4003. 15 October 1997

Tumor necrosis factor in Plasmodium falciparum malaria: high plasma level is associated with fever, but high production capacity is associated with rapid fever clearance.
Mordmueller, B.G. and Metzger, W.G. and Juillard, P. and Brinkman, B.M. and Verweij, C.L. and Grau, G.E. and Kremsner, P.G.
European Cytokine Network 8 : 29-35. 1 March 1997

Regulation of NF-kappa B activity by I kappa B alpha and I kappa B beta stability.
Krappmann, D. and Scheidereit, C.
Immunobiology 198 : 3-13. 1 January 1997

The role of oxygen metabolism for the pathological phenotype of fanconi anemia.
Ruppitsch, W. and Meisslitzer, C. and Weirichschwaiger, H. and Klocker, H. and Scheidereit, C. and Schweiger, M. and Hirschkauffmann, M.
Human Genetics 99 : 710-719. 1 January 1997


Different mechanisms control signal-induced degradation and basal turnover of the NF-kappab inhibitor ikappabalpha in vivo.
Krappmann, D. and Wulczyn, F.G. and Scheidereit, C.
EMBO Journal 15 (23): 6716-6726. 2 December 1996

NF-kappaB activity in transgenic mice: developmental regulation and tissue specificity.
Schmidt-Ullrich, R. and Memet, S. and Lilienbaum, A. and Feuillard, J. and Raphael, M. and Israel, A.
Development 122 (7): 2117-2128. July 1996

High level nuclear NF-kB and Oct-2 is a common feature of cultured Hodgkin/Sternberg cells.
Bargou, R.C. and Leng, C. and Krappmann, D. and Emmerich, F. and Mapara, M.Y. and Bommert, K. and Royer, H.D. and Scheidereit, C. and Doerken, B.
Blood 87 (10): 4340-4347. 1 January 1996

The NF-kappaB/Rel and IkappaB gene families: mediators of immune response and inflammation.
Wulczyn, F.G. and Krappmann, D. and Scheidereit, C.
Journal of Molecular Medicine 74 : 749-769. 1 January 1996

Transcription factors: important tools and targets for molecular medicine.
Scheidereit, C.
Journal of Molecular Medicine 74 : 707-709. 1 January 1996


Sequence-specific recognition of a repetitive DNA element by a C2H2 zinc-finger protein in Xenopus.
Schafer, U. and Rausch, O. and Bouwmeester, T. and Pieler, T.
European Journal of Biochemistry 226 : 567-576. 1 December 1994

Activation of NF-kappaB in vivo is regulated by multiple phosphorylations.
Naumann, M. and Scheidereit, C.
EMBO Journal 13 (19): 4597-4607. 3 October 1994

Identification of novel ubiquitous and cell type-specific factors that specifically recognize immunoglobulin heavy and light chain promoters.
Franke, S. and Scholz, G. and Scheidereit, C.
Journal of Biological Chemistry 269 (31): 20075-20082. 5 August 1994

Functional aspects of B-Myb in early Xenopus development.
Bouwmeester, T. and van Wijk, I. and Wedlich, D. and Pieler, T.
Oncogene 9 (4): 1029-1038. April 1994

The FAR domain defines a new Xenopus laevis zinc finger protein subfamily with specific RNA homopolymer binding activity.
Klocke, B. and Koester, M. and Hille, S. and Bouwmeester, T. and Boehm, S. and Pieler, T. and Knoechel, W.
Biochimica et Biophysica Acta 1217 : 81-89. 1 January 1994


NF-kappaB precursor p100 inhibits nuclear translocation and DNA binding of NF-kappaB/rel-factors.
Naumann, M. and Nieters, A. and Hatada, E.N. and Scheidereit, C.
Oncogene 8 (8): 2275-2281. 1 August 1993

Common structural constituents confer IkappaB activity to NF-kappaB p105 and IkappaB/MAD-3.
Hatada, E.N. and Naumann, M. and Scheidereit, C.
EMBO Journal 12 (7): 2781-2788. July 1993

The NF-kappaB precursor p105 and the proto-oncogene product Bcl- 3 are I kappa B molecules and control nuclear translocation of NF-kappa B.
Naumann, M. and Wulczyn, F.G. and Scheidereit, C.
EMBO Journal 12 (1): 213-222. January 1993


Transcriptional regulation of the HIV-1 promoter by NF-kappa B in vitro.
Kretzschmar, M. and Meisterernst, M. and Scheidereit, C. and Li, G. and Roeder, R.G.
Genes & Development 6 (5): 761-774. May 1992

Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappaB.
Wulczyn, F.G. and Naumann, M. and Scheidereit, C.
Nature 358 (6387): 597-599. 1 January 1992

The ankyrin repeat domains of the NF-kappa B precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-kappaB DNA binding.
Hatada, E.N. and Nieters, A. and Wulczyn, F.G. and Naumann, M. and Meyer, R. and Nucifora, G. and McKeithan, T.W. and Scheidereit, C.
Proceedings of the National Academy of Sciences of the United States of America 89 (6): 2489-2493. 1 January 1992

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