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2018

Chromatin accessibility dynamics across C. elegans development and ageing.
Jänes, J. and Dong, Y. and Schoof, M. and Serizay, J. and Appert, A. and Cerrato, C. and Woodbury, C. and Chen, R. and Gemma, C. and Huang, N. and Kissiov, D. and Stempor, P. and Steward, A. and Zeiser, E. and Sauer, S. and Ahringer, J.
eLife 7 : e37344. 26 October 2018

The nuclear receptor PPARγ controls progressive macrophage polarization as a ligand-insensitive epigenomic ratchet of transcriptional memory.
Daniel, B. and Nagy, G. and Czimmerer, Z. and Horvath, A. and Hammers, D.W. and Cuaranta-Monroy, I. and Poliska, S. and Tzerpos, P. and Kolostyak, Z. and Hays, T.T. and Patsalos, A. and Houtman, R. and Sauer, S. and Francois-Deleuze, J. and Rastinejad, F. and Balint, B.L. and Sweeney, H.L. and Nagy, L.
Immunity 49 (4): 615-626. 16 October 2018

Extensive and functional overlap of the STAT6 and RXR cistromes in the active enhancer repertoire of human CD14+ monocyte derived differentiating macrophages.
Czimmerer, Z. and Nagy, Z.S. and Nagy, G. and Horvath, A. and Silye-Cseh, T. and Kriston, A. and Jonas, D. and Sauer, S. and Steiner, L. and Daniel, B. and Deleuze, J.F. and Nagy, L.
Molecular and Cellular Endocrinology 471 : 63-74. 15 August 2018

RXR heterodimers orchestrate transcriptional control of neurogenesis and cell fate specification.
Simandi, Z. and Horvath, A. and Cuaranta-Monroy, I. and Sauer, S. and Deleuze, J.F. and Nagy, L.
Molecular and Cellular Endocrinology 471 : 51-62. 15 August 2018

Transient N-6-methyladenosine transcriptome sequencing reveals a regulatory role of m6A in splicing efficiency.
Louloupi, A. and Ntini, E. and Conrad, T. and Ørom, U.A.V.
Cell Reports 23 (12): 3429-3437. 19 June 2018

Chromatin accessibility is dynamically regulated across C. elegans development and ageing.
Janes, J. and Dong, Y. and Schoof, M. and Serizay, J. and Appert, A. and Cerrato, C. and Woodbury, C. and Chen, R. and Gemma, C. and Huang, N. and Kissiov, D. and Stempor, P. and Steward, A. and Zeiser, E. and Sauer, S. and Ahringer, J.
bioRxiv : 279158. 10 June 2018

Loss of the hematopoietic stem cell factor GATA2 in the osteogenic lineage impairs trabecularization and mechanical strength of bone.
Tolkachov, A. and Fischer, C. and Ambrosi, T.H. and Bothe, M. and Han, C.T. and Muenzner, M. and Mathia, S. and Salminen, M. and Seifert, G. and Thiele, M. and Duda, G.N. and Meijsing, S.H. and Sauer, S. and Schulz, T.J. and Schupp, M.
Molecular and Cellular Biology 38 (12): e00599-17. June 2018

The IL-4/STAT6/PPARγ signaling axis is driving the expansion of the RXR heterodimer cistrome, providing complex ligand responsiveness in macrophages.
Daniel, B. and Nagy, G. and Horvath, A. and Czimmerer, Z. and Cuaranta-Monroy, I. and Poliska, S. and Hays, T.T. and Sauer, S. and Francois-Deleuze, J. and Nagy, L.
Nucleic Acids Research 46 (9): 4425-4439. 18 May 2018

Faecal microbiota composition associates with abdominal pain in the general population.
Hadizadeh, F. and Bonfiglio, F. and Belheouane, M. and Vallier, M. and Sauer, S. and Bang, C. and Bujanda, L. and Andreasson, A. and Agreus, L. and Engstrand, L. and Talley, N.J. and Rafter, J. and Baines, J.F. and Walter, S. and Franke, A. and D'Amato, M.
Gut 67 (4): 778-779. 8 March 2018

De novo mutations implicate novel genes in systemic lupus erythematosus.
Pullabhatla, V. and Roberts, A.L. and Lewis, M.J. and Mauro, D. and Morris, D.L. and Odhams, C.A. and Tombleson, P. and Liljedahl, U. and Vyse, S. and Simpson, M.A. and Sauer, S. and de Rinaldis, E. and Syvänen, A.C. and Vyse, T.J.
Human Molecular Genetics 27 (3): 421-429. 1 February 2018

The transcription factor STAT6 mediates direct repression of inflammatory enhancers and limits activation of alternatively polarized macrophages.
Czimmerer, Z. and Daniel, B. and Horvath, A. and Rückerl, D. and Nagy, G. and Kiss, M. and Peloquin, M. and Budai, M.M. and Cuaranta-Monroy, I. and Simandi, Z. and Steiner, L. and Nagy, B. and Poliska, S. and Banko, C. and Bacso, Z. and Schulman, I.G. and Sauer, S. and Deleuze, J.F. and Allen, J.E. and Benko, S. and Nagy, L.
Immunity 48 (1): 75-90. 16 January 2018

Perturbation-response genes reveal signaling footprints in cancer gene expression.
Schubert, M. and Klinger, B. and Klünemann, M. and Sieber, A. and Uhlitz, F. and Sauer, S. and Garnett, M.J. and Blüthgen, N. and Saez-Rodriguez, J.
Nature Communications 9 (1): 20. 2 January 2018

2017

Polylox barcoding reveals haematopoietic stem cell fates realized in vivo.
Pei, W. and Feyerabend, T.B. and Rössler, J. and Wang, X. and Postrach, D. and Busch, K. and Rode, I. and Klapproth, K. and Dietlein, N. and Quedenau, C. and Chen, W. and Sauer, S. and Wolf, S. and Höfer, T. and Rodewald, H.Re.
Nature 548 (7668): 456-460. 24 August 2017

De novo mutations implicate novel genes with burden of rare variants in systemic lupus erythematosus.
Pullabhatla, V. and Roberts, A.L. and Lewis, M.J. and Mauro, D. and Morris, D.L. and Odhams, C.A. and Tombleson, P. and Liljedahld, U. and Vyse, S. and Simpson, M.A. and Sauer, S. and de Rinaldis, E. and Syvaenen, A.C. and Vyse, T.J.
bioRxiv : 139238. 14 August 2017

Signatures of personality on dense 3D facial images.
Hu, S. and Xiong, J. and Fu, P. and Qiao, L. and Tan, J. and Jin, L. and Tang, K.
Scientific Reports 7 (1): 73. March 2017

RNA-seq based transcriptome analysis of the type I interferon host response upon vaccinia virus infection of mouse cells.
Hernáez, B. and Alonso, G. and Alonso-Lobo, J.M. and Rastrojo, A. and Fischer, C. and Sauer, S. and Aguado, B. and Alcamí, A.
Journal of Immunology Research 2017 : 5157626. 9 February 2017

Health-beneficial nutraceuticals - myth or reality?
Sauer, S. and Plauth, A.
Applied Microbiology and Biotechnology 101 (3): 951-961. February 2017

2016

Data of oxygen- and pH-dependent oxidation of resveratrol.
Plauth, A. and Geikowski, A. and Cichon, S. and Wowro, S.J. and Liedgens, L. and Rousseau, M. and Weidner, C. and Fuhr, L. and Kliem, M. and Jenkins, G. and Lotito, S. and Wainwright, L.J. and Sauer, S.
Data in Brief 9 : 433-437. December 2016

The International Human Epigenome Consortium: a blueprint for scientific collaboration and discovery.
Stunnenberg, H.G. and Hirst, M.
Cell 167 (7): 1145-1149. 17 November 2016

Efficient application of de novo RNA assemblers for proteomics informed by transcriptomics.
Luge, T. and Fischer, C. and Sauer, S.
Journal of Proteome Research 15 (10): 3938-3943. 7 October 2016

Dissecting the effect of genetic variation on the hepatic expression of drug disposition genes across the collaborative cross mouse strains.
Nachshon, A. and Abu-Toamih Atamni, H.J. and Steuerman, Y. and Sheikh-Hamed, R. and Dorman, A. and Mott, R. and Dohm, J.C. and Lehrach, H. and Sultan, M. and Shamir, R. and Sauer, S. and Himmelbauer, H. and Iraqi, F.A. and Gat-Viks, I.
Frontiers in Genetics 7 : 172. 5 October 2016

Hormetic shifting of redox environment by pro-oxidative resveratrol protects cells against stress.
Plauth, A. and Geikowski, A. and Cichon, S. and Wowro, S.J. and Liedgens, L. and Rousseau, M. and Weidner, C. and Fuhr, L. and Kliem, M. and Jenkins, G. and Lotito, S. and Wainwright, L.J. and Sauer, S.
Free Radical Biology and Medicine 99 : 608-622. October 2016

OCT4 acts as an integrator of pluripotency and signal-induced differentiation.
Simandi, Z. and Horvath, A. and Wright, L.C. and Cuaranta-Monroy, I. and De Luca, I. and Karolyi, K. and Sauer, S. and Deleuze, J.F. and Gudas, L.J. and Cowley, S.M. and Nagy, L.
Molecular Cell 63 (4): 647-661. 18 August 2016

TTC25 deficiency results in defects of the outer dynein arm docking machinery and primary ciliary dyskinesia with left-right body asymmetry randomization.
Wallmeier, J. and Shiratori, H. and Dougherty, G.W. and Edelbusch, C. and Hjeij, R. and Loges, N.T. and Menchen, T. and Olbrich, H. and Pennekamp, P. and Raidt, J. and Werner, C. and Minegishi, K. and Shinohara, K. and Asai, Y. and Takaoka, K. and Lee, C. and Griese, M. and Memari, Y. and Durbin, R. and Kolb-Kokocinski, A. and Sauer, S. and Wallingford, J.B. and Hamada, H. and Omran, H.
American Journal of Human Genetics 99 (2): 460-469. 4 August 2016

A novel splicing mutation in the IQSEC2 gene that modulates the phenotype severity in a family with intellectual disability.
Madrigal, I. and Alvarez-Mora, M.I. and Rosell, J. and Rodríguez-Revenga, L. and Karlberg, O. and Sauer, S. and Syvänen, A.C. and Mila, M.
European Journal of Human Genetics 24 (8): 1117-1123. August 2016

Identification and characterization of DNA sequences that prevent glucocorticoid receptor binding to nearby response elements.
Telorac, J. and Prykhozhij, S.V. and Schöne, S. and Meierhofer, D. and Sauer, S. and Thomas-Chollier, M. and Meijsing, S.H.
Nucleic Acids Research 44 (13): 6142-6156. 27 July 2016

Deficient methylation and formylation of mt-tRNA(Met) wobble cytosine in a patient carrying mutations in NSUN3.
Van Haute, L. and Dietmann, S. and Kremer, L. and Hussain, S. and Pearce, S.F. and Powell, C.A. and Rorbach, J. and Lantaff, R. and Blanco, S. and Sauer, S. and Kotzaeridou, U. and Hoffmann, G.F. and Memari, Y. and Kolb-Kokocinski, A. and Durbin, R. and Mayr, J.A. and Frye, M. and Prokisch, H. and Minczuk, M.
Nature Communications 7 : 12039. 30 June 2016

New technologies for DNA analysis - a review of the READNA project.
McGinn, S. and Bauer, D. and Brefort, T. and Dong, L. and El-Sagheer, A. and Elsharawy, A. and Evans, G. and Falk-Sörqvist, E. and Forster, M. and Fredriksson, S. and Freeman, P. and Freitag, C. and Fritzsche, J. and Gibson, S. and Gullberg, M. and Gut, M. and Heath, S. and Heath-Brun, I. and Heron, A.J. and Hohlbein, J. and Ke, R. and Lancaster, O. and Le Reste, L. and Maglia, G. and Marie, R. and Mauger, F. and Mertes, F. and Mignardi, M. and Moens, L. and Oostmeijer, J. and Out, R. and Pedersen, J.N. and Persson, F. and Picaud, V. and Rotem, D. and Schracke, N. and Sengenes, J. and Stähler, P.F. and Stade, B. and Stoddart, D. and Teng, X. and Veal, C.D. and Zahra, N. and Bayley, H. and Beier, M. and Brown, T. and Dekker, C. and Ekström, B. and Flyvbjerg, H. and Franke, A. and Guenther, S. and Kapanidis, A.N. and Kaye, J. and Kristensen, A. and Lehrach, H. and Mangion, J. and Sauer, S. and Schyns, E. and Tost, J. and van Helvoort, J.M.L.M. and van der Zaag, P.J. and Tegenfeldt, J.O. and Brookes, A.J. and Mir, K. and Nilsson, M. and Willcocks, J.P. and Gut, I.G.
New Biotechnology 33 (3): 311-330. 25 May 2016

Phosphorylation of the chromatin remodeling factor DPF3a induces cardiac hypertrophy through releasing HEY repressors from DNA.
Cui, H. and Schlesinger, J. and Schoenhals, S. and Toenjes, M. and Dunkel, I. and Meierhofer, D. and Cano, E. and Schulz, K. and Berger, M.F. and Haack, T. and Abdelilah-Seyfried, S. and Bulyk, M.L. and Sauer, S. and Sperling, S.R.
Nucleic Acids Research 44 (6): 2538-2553. 7 April 2016

Iberis amara extract induces intracellular formation of reactive oxygen species and inhibits colon cancer.
Weidner, C. and Rousseau, M. and Plauth, A. and Wowro, S.J. and Fischer, C. and Abdel-Aziz, H. and Sauer, S.
PLoS ONE 11 (4): e0152398. 6 April 2016

Serial interactome capture of the human cell nucleus.
Conrad, T. and Albrecht, A.-S. and Rodrigues de Melo Costa, V. and Sauer, S. and Meierhofer, D. and Ørom, U.A.
Nature Communications 7 : 11212. 4 April 2016

Hormetic shifting of redox environment by pro-oxidative resveratrol protects cells against stress.
Plauth, A. and Geikowski, A. and Cichon, S. and Wowro, S.J. and Liedgens, L. and Rousseau, M. and Weidner, C. and Fuhr, L. and Kliem, M. and Jenkins, G. and Lotito, S. and Wainwright, L.J. and Sauer, S.
bioRxiv : 045567. 24 March 2016

Identification of novel genetic causes of Rett syndrome-like phenotypes.
Lopes, F. and Barbosa, M. and Ameur, A. and Soares, G. and de Sá, J. and Dias, A.I. and Oliveira, G. and Cabral, P. and Temudo, T. and Calado, E. and Cruz, I.F. and Vieira, J.P. and Oliveira, R. and Esteves, S. and Sauer, S. and Jonasson, I. and Syvänen, A.C. and Gyllensten, U. and Pinto, D. and Maciel, P.
Journal of Medical Genetics 53 (3): 190-199. March 2016

Bi-allelic truncating mutations in TANGO2 cause infancy-onset recurrent metabolic crises with encephalocardiomyopathy.
Kremer, L.S. and Distelmaier, F. and Alhaddad, B. and Hempel, M. and Iuso, A. and Küpper, C. and Mühlhausen, C. and Kovacs-Nagy, R. and Satanovskij, R. and Graf, E. and Berutti, R. and Eckstein, G. and Durbin, R. and Sauer, S. and Hoffmann, G.F. and Strom, T.M. and Santer, R. and Meitinger, T. and Klopstock, T. and Prokisch, H. and Haack, T.B.
American Journal of Human Genetics 98 (2): 358-362. 4 February 2016

Analysis of genes involved in body weight regulation by targeted re-sequencing.
Volckmar, A.L. and Han, C.T. and Pütter, C. and Haas, S. and Vogel, C.I.G. and Knoll, N. and Struve, C. and Göbel, M. and Haas, K. and Herrfurth, N. and Jarick, I. and Grallert, H. and Schürmann, A. and Al-Hasani, H. and Hebebrand, J. and Sauer, S. and Hinney, A.
PLOS ONE 11 (2): e0147904. 1 February 2016

Epigenetic profiling in CD4+ and CD8+ T cells from Graves' disease patients reveals changes in genes associated with T cell receptor signaling.
Limbach, M. and Saare, M. and Tserel, L. and Kisand, K. and Eglit, T. and Sauer, S. and Axelsson, T. and Syvänen, A.C. and Metspalu, A. and Milani, L. and Peterson, P.
Journal of Autoimmunity 67 : 46-56. February 2016

Generating sample-specific databases for mass spectrometry-based proteomic analysis by using RNA sequencing.
Luge, T. and Sauer, S.
Methods in Molecular Biology 1394 : 219-232. 2016

2015

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism.
Correia, J.C. and Massart, J. and de Boer, J.F. and Porsmyr-Palmertz, M. and Martínez-Redondo, V. and Agudelo, L.Z. and Sinha, I. and Meierhofer, D. and Ribeiro, V. and Björnholm, M. and Sauer, S. and Dahlman-Wright, K. and Zierath, J.R. and Groen, A.K. and Ruas, J.L.
Molecular Metabolism 4 (12): 891-902. December 2015

Immunofluorescence analysis and diagnosis of primary ciliary dyskinesia with radial spoke defects.
Frommer, A. and Hjeij, R. and Loges, N.T. and Edelbusch, C. and Jahnke, C. and Raidt, J. and Werner, C. and Wallmeier, J. and Große-Onnebrink, J. and Olbrich, H. and Cindrić, S. and Jaspers, M. and Boon, M. and Memari, Y. and Durbin, R. and Kolb-Kokocinski, A. and Sauer, S. and Marthin, J.K. and Nielsen, K.G. and Amirav, I. and Elias, N. and Kerem, E. and Shoseyov, D. and Haeffner, K. and Omran, H.
American Journal of Respiratory Cell and Molecular Biology 53 (4): 563-573. 1 October 2015

Ligands for the nuclear peroxisome proliferator-activated receptor gamma.
Sauer, S.
Trends in Pharmacological Sciences 36 (10): 688-704. October 2015

Development of a high-resolution NGS-based HLA-typing and analysis pipeline.
Wittig, M. and Anmarkrud, J.A. and Kässens, J.C. and Koch, S. and Forster, M. and Ellinghaus, E. and Hov, J.R. and Sauer, S. and Schimmler, M. and Ziemann, M. and Görg, S. and Jacob, F. and Karlsen, T.H. and Franke, A.
Nucleic Acids Research 43 (11): e70. 23 June 2015

Deep sequencing of the trypanosoma cruzi GP63 surface proteases reveals diversity and diversifying selection among chronic and congenital Chagas disease patients.
Llewellyn, M.S. and Messenger, L.A. and Luquetti, A.O. and Garcia, L. and Torrico, F. and Tavares, S.B.N. and Cheaib, B. and Derome, N. and Delepine, M. and Baulard, C. and Deleuze, J.F. and Sauer, S. and Miles, M.A.
PLoS Neglected Tropical Diseases 9 (4): e0003458. 7 April 2015

Nutriproteomics: facts, concepts, and perspectives.
Sauer, S. and Luge, T.
Proteomics 15 (5-6): 997-1013. March 2015

A common building block for the syntheses of amorfrutin and cajaninstilbene acid libraries toward efficient binding with peroxisome proliferator-activated receptors.
Aidhen, I.S. and Mukkamala, R. and Weidner, C. and Sauer, S.
Organic Letters 17 (2): 194-197. 16 January 2015

2014

Amorfrutins: a promising class of natural products that are beneficial to health.
Sauer, S.
Chembiochem 15 (9): 1231-1238. 16 June 2014

2013

Comprehensive proteomic data sets for studying adipocyte-macrophage cell-cell communication.
Freiwald, A. and Weidner, C. and Witzke, A. and Huang, S.Y. and Meierhofer, D. and Sauer, S.
Proteomics 13 (23-24): 3424-3428. December 2013

Diagnostic proteomics: will this impact the clinic?
Sauer, S.
Proteomics Clinical Applications 7 (11-12): 725-726. December 2013

Antidiabetic effects of chamomile flowers extract in obese mice through transcriptional stimulation of nutrient sensors of the peroxisome proliferator-activated receptor (PPAR) family.
Weidner, C. and Wowro, S.J. and Rousseau, M. and Freiwald, A. and Kodelja, V. and Abdel-Aziz, H. and Kelber, O. and Sauer, S.
PLOS ONE 8 (11): e80335. 12 November 2013

Protein set analyses: how could this impact the clinic?
Sauer, S.
Expert Review of Proteomics 10 (4): 305-307. August 2013

Protein sets define disease states and predict in vivo effects of drug treatment.
Meierhofer, D. and Weidner, C. and Hartmann, L. and Mayr, J.A. and Han, C.T. and Schroeder, F.C. and Sauer, S.
Molecular & Cellular Proteomics 12 (7): 1965-1979. 1 July 2013

Genome-wide analysis of LXRα activation reveals new transcriptional networks in human atherosclerotic foam cells.
Feldmann, R. and Fischer, C. and Kodelja, V. and Behrens, S. and Haas, S. and Vingron, M. and Timmermann, B. and Geikowski, A. and Sauer, S.
Nucleic Acids Research 41 (6): 3518-3531. April 2013

2012

Amorfrutins are potent antidiabetic dietary natural products.
Weidner, C. and de Groot, J.C. and Prasad, A. and Freiwald, A. and Quedenau, C. and Kliem, M. and Witzke, A. and Kodelja, V. and Han, C.T. and Giegold, S. and Baumann, M. and Klebl, B. and Siems, K. and Müller-Kuhrt, L. and Schürmann, A. and Schüler, R. and Pfeiffer, A.F.H. and Schroeder, F.C. and Büssow, K. and Sauer, S.
Proceedings of the National Academy of Sciences of the United States of America 109 (19): 7257-7262. 8 May 2012

2011

Targeted enrichment of genomic DNA regions for next-generation sequencing.
Mertes, F. and Elsharawy, A. and Sauer, S. and van Helvoort, J.M.L.M. and van der Zaag, P.J. and Franke, A. and Nilsson, M. and Lehrach, H. and Brookes, A.J.
Briefings in Functional Genomics 10 (6): 374-386. November 2011

2010

DNA polymorphisms and haplotype patterns of transcription factors involved in barley endosperm development are associated with key agronomic traits.
Haseneyer, G. and Stracke, S. and Piepho, H.-P. and Sauer, S. and Geiger, H.H. and Graner, A.
BMC Plant Biology 10 : 5. 8 January 2010

Familiality and molecular genetics of attention networks in ADHD.
Konrad, K. and Dempfle, A. and Friedel, S. and Heiser, P. and Holtkamp, K. and Walitza, S. and Sauer, S. and Warnke, A. and Remschmidt, H. and Gilsbach, S. and Schäfer, H. and Hinney, A. and Hebebrand, J. and Herpertz-Dahlmann, B.
American Journal of Medical Genetics B 153B (1): 148-158. 5 January 2010

Mass spectrometry tools for the classification and identification of bacteria.
Sauer, S. and Kliem, M.
Nature Reviews Microbiology 8 (1): 74-82. 1 January 2010

2009

Quantification of target proteins using hydrogel antibody arrays and MALDI time-of-flight mass spectrometry (A2M2S).
Darii, E. and Lebeau, D. and Papin, N. and Rubina, A.Y. and Stomakhin, A. and Tost, J. and Sauer, S. and Savvateeva, E. and Dementieva, E. and Zasedatelev, A. and Makarov, A.A. and Gut, I.G.
New Biotechnology 25 (6): 404-416. 15 September 2009

Phylogenetic classification and identification of bacteria by mass spectrometry.
Freiwald, A. and Sauer, S.
Nature Protocols 4 (5): 732-742. 23 April 2009

Identification of novel transcriptional regulators involved in macrophage differentiation and activation in U937 cells.
Baek, Y.-S. and Haas, S. and Hackstein, H. and Bein, G. and Hernandez-Santana, M. and Lehrach, H. and Sauer, S. and Seitz, H.
BMC Immunology 10 : 18. 2 April 2009

Association mapping reveals gene action and interactions in the determination of flowering time in barley.
Stracke, S. and Haseneyer, G. and Veyrieras, J.B. and Geiger, H.H. and Sauer, S. and Graner, A. and Piepho, H.P.
Theoretical and Applied Genetics 118 (2): 259-273. January 2009

2008

Classification and identification of bacteria by mass spectrometry and computational analysis.
Sauer, S. and Freiwald, A. and Maier, T. and Kube, M. and Reinhardt, R. and Kostrzewa, M. and Geider, K.
PLOS ONE 3 (7): e2843. 30 July 2008

2006

Single-nucleotide polymorphisms: analysis by mass spectrometry.
Sauer, S. and Reinhardt, R. and Lehrach, H. and Gut, I.G.
Nature Protocols 1 (4): 1761-1771. 22 November 2006

This list was generated on Wed Nov 14 02:19:00 2018 CET.
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