Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Browse by Research Team

Export as [feed] Atom [feed] RSS 1.0 [feed] RSS 2.0
Group by: Date | Item Type | Source

Article

Generation of induced pluripotent stem cells from three individuals with Huntington's disease.
Miller, D.C. and Lisowski, P. and Lickfett, S. and Mlody, B. and Bünning, M. and Genehr, C. and Ulrich, C. and Wanker, E.E. and Diecke, S. and Priller, J. and Prigione, A.
Stem Cell Research 65 : 102976. December 2022

Generation of four iPSC lines from four patients with Leigh syndrome carrying homoplasmic mutations m.8993T > G or m.8993T > C in the mitochondrial gene MT-ATP6.
Lorenz, C. and Zink, A. and Henke, M.T. and Staege, S. and Mlody, B. and Bünning, M. and Wanker, E. and Diecke, S. and Schuelke, M. and Prigione, A.
Stem Cell Research 61 : 102742. May 2022

Mitochondria in neurogenesis: implications for mitochondrial diseases.
Brunetti, D. and Dykstra, W. and Le, S. and Zink, A. and Prigione, A.
Stem Cells 39 (10): 1289-1297. October 2021

Generation of human brain organoids for mitochondrial disease modeling.
Le, S. and Petersilie, L. and Inak, G. and Menacho-Pando, C. and Kafitz, K.W. and Rybak-Wolf, A. and Rajewsky, N. and Rose, C.R. and Prigione, A.
Journal of Visualized Experiments (172): e62756. 21 June 2021

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G. and Rybak-Wolf, A. and Lisowski, P. and Pentimalli, T.M. and Jüttner, R. and Glažar, P. and Uppal, K. and Bottani, E. and Brunetti, D. and Secker, C. and Zink, A. and Meierhofer, D. and Henke, M.T. and Dey, M. and Ciptasari, U. and Mlody, B. and Hahn, T. and Berruezo-Llacuna, M. and Karaiskos, N. and Di Virgilio, M. and Mayr, J.A. and Wortmann, S.B. and Priller, J. and Gotthardt, M. and Jones, D.P. and Mayatepek, E. and Stenzel, W. and Diecke, S. and Kühn, R. and Wanker, E.E. and Rajewsky, N. and Schuelke, M. and Prigione, A.
Nature Communications 12 (1): 1929. 26 March 2021

Generation of human iPSC-derived neural progenitor cells (NPCs) as drug discovery model for neurological and mitochondrial disorders.
Zink, A. and Lisowski, P. and Prigione, A.
Bio-protocol 11 (5): e3939. 5 March 2021

Assessment of ethanol-induced toxicity on iPSC-derived human dopaminergic neurons using a novel high-throughput mitochondrial neuronal health (MNH) assay.
Zink, A. and Conrad, J. and Telugu, N.S. and Diecke, S. and Heinz, A. and Wanker, E. and Priller, J. and Prigione, A.
Frontiers in Cell and Developmental Biology 8 : 590540. 5 November 2020

PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.
Delgado-Benito, V. and Berruezo-Llacuna, M. and Altwasser, R. and Winkler, W. and Sundaravinayagam, D. and Balasubramanian, S. and Caganova, M. and Graf, R. and Rahjouei, A. and Henke, M.T. and Driesner, M. and Keller, L. and Prigione, A. and Janz, M. and Akalin, A. and Di Virgilio, M.
Journal of Experimental Medicine 217 (10): e20200137. 5 October 2020

Nuclear inclusions of pathogenic ataxin-1 induce oxidative stress and perturb the protein synthesis machinery.
Laidou, S. and Alanis-Lobato, G. and Pribyl, J. and Raskó, T. and Tichy, B. and Mikulasek, K. and Tsagiopoulou, M. and Oppelt, J. and Kastrinaki, G. and Lefaki, M. and Singh, M. and Zink, A. and Chondrogianni, N. and Psomopoulos, F. and Prigione, A. and Ivics, Z. and Pospisilova, S. and Skladal, P. and Izsvák, Z. and Andrade-Navarro, M.A. and Petrakis, S.
Redox Biology 32 : 101458. May 2020

Novel calcineurin A (PPP3CA) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression.
Rydzanicz, M. and Wachowska, M. and Cook, E.C. and Lisowski, P. and Kuźniewska, B. and Szymańska, K. and Diecke, S. and Prigione, A. and Szczałuba, K. and Szybińska, A. and Koppolu, A. and Murcia Pienkowski, V. and Kosińska, J. and Wiweger, M. and Kostrzewa, G. and Brzozowska, M. and Domańska-Pakieła, D. and Jurkiewicz, E. and Stawiński, P. and Gromadka, A. and Zielenkiewicz, P. and Demkow, U. and Dziembowska, M. and Kuźnicki, J. and Creamer, T.P. and Płoski, R.
European Journal of Human Genetics 27 (1): 61-69. January 2019

Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex.
Scior, A. and Buntru, A. and Arnsburg, K. and Ast, A. and Iburg, M. and Juenemann, K. and Pigazzini, M.L. and Mlody, B. and Puchkov, D. and Priller, J. and Wanker, E.E. and Prigione, A. and Kirstein, J.
EMBO Journal 37 (2): 282-299. 17 January 2018

Human mesenchymal factors induce rat hippocampal- and human neural stem cell dependent oligodendrogenesis.
Jadasz, J.J. and Tepe, L. and Beyer, F. and Samper Agrelo, I. and Akkermann, R. and Spitzhorn, L.S. and Silva, M.E. and Oreffo, R.O.C. and Hartung, H.P. and Prigione, A. and Rivera, F.J. and Adjaye, J. and Kuery, P.
Glia 66 (1): 145-160. January 2018

Human iPSC-derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders.
Lorenz, C. and Lesimple, P. and Bukowiecki, R. and Zink, A. and Inak, G. and Mlody, B. and Singh, M. and Semtner, M. and Mah, N. and Auré, K. and Leong, M. and Zabiegalov, O. and Lyras, E.M. and Pfiffer, V. and Fauler, B. and Eichhorst, J. and Wiesner, B. and Huebner, N. and Priller, J. and Mielke, T. and Meierhofer, D. and Izsvák, Z. and Meier, J.C. and Bouillaud, F. and Adjaye, J. and Schuelke, M. and Wanker, E.E. and Lombès, A. and Prigione, A.
Cell Stem Cell 20 (5): 659-674.e9. 4 May 2017

A movement disorder with dystonia and ataxia caused by a mutation in the HIBCH gene.
Schottmann, G. and Sarpong, A. and Lorenz, C. and Weinhold, N. and Gill, E. and Teschner, L. and Ferdinandusse, S. and Wanders, R.J.A. and Prigione, A. and Schuelke, M.
Movement Disorders 31 (11): 1733-1739. November 2016

Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression.
Wang, J. and Singh, M. and Sun, C. and Besser, D. and Prigione, A. and Ivics, Z. and Hurst, L.D. and Izsvák, Z.
Nature Protocols 11 (2): 327-346. February 2016

Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A.
Rohwer, N. and Bindel, F. and Grimm, C. and Lin, S.J. and Wappler, J. and Klinger, B. and Blüthgen, N. and Du Bois, I. and Schmeck, B. and Lehrach, H. and de Graauw, M. and Goncalves, E. and Saez-Rodriguez, J. and Tan, P. and Grabsch, H.I. and Prigione, A. and Kempa, S. and Cramer, T.
Oncotarget 7 (6): 6693-6710. 29 December 2015

Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks.
Hossini, A.M. and Megges, M. and Prigione, A. and Lichtner, B. and Toliat, M.R. and Wruck, W. and Schroeter, F. and Nuernberg, P. and Kroll, H. and Makrantonaki, E. and Zoubouliss, C.C. and Adjaye, J.
BMC Genomics 16 (1): 84. 14 February 2015

Induced pluripotent stem cells (iPSCs) for modeling mitochondrial DNA disorders.
Prigione, A.
Methods in Molecular Biology 1265 : 349-356. 6 January 2015

Assessing the bioenergetic profile of human pluripotent stem cells.
Pfiffer, V. and Prigione, A.
Methods in Molecular Biology 1264 : 279-288. 2015

Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.
Wang, J. and Xie, G. and Singh, M. and Ghanbarian, A.T. and Raskó, T. and Szvetnik, A. and Cai, H. and Besser, D. and Prigione, A. and Fuchs, N.V. and Schumann, G.G. and Chen, W. and Lorincz, M.C. and Ivics, Z. and Hurst, L.D. and Izsvák, Z.
Nature 516 (7531): 405-409. 18 December 2014

HIF1α modulates reprogramming through early glycolytic shift and up-regulation of PDK1-3 and PKM2.
Prigione, A. and Rohwer, N. and Hoffman, S. and Mlody, B. and Drews, K. and Bukowiecki, R. and Bluemlein, K. and Wanker, E.E. and Ralser, M. and Cramer, T. and Adjaye, J.
Stem Cells 32 (2): 364-376. February 2014

Mitochondrial function in pluripotent stem cells and cellular reprogramming.
Bukowiecki, R. and Adjaye, J. and Prigione, A.
Gerontology 60 (2): 174-182. February 2014

Teratoma formation of human embryonic stem cells in three-dimensional perfusion culture bioreactors.
Stachelscheid, H. and Wulf-Goldenberg, A. and Eckert, K. and Jensen, J. and Edsbagge, J. and Bjoerquist, P. and Rivero, M. and Strehl, R. and Jozefczuk, J. and Prigione, A. and Adjaye, J. and Urbaniak, T. and Bussmann, P. and Zeilinger, K. and Gerlach, J.C.
Journal of Tissue Engineering and Regenerative Medicine 7 (9): 729-741. September 2013

Transcriptome based identification of mouse cumulus cell markers that predict the developmental competence of their enclosed antral oocytes.
Vigone, G. and Merico, V. and Prigione, A. and Mulas, F. and Sacchi, L. and Gabetta, M. and Bellazzi, R. and Redi, C.A. and Mazzini, G. and Adjaye, J. and Garagna, S. and Zuccotti, M.
BMC Genomics 14 : 380. 7 June 2013

Human stromal (mesenchymal) stem cells from bone marrow, adipose tissue and skin exhibit differences in molecular phenotype and differentiation potential.
Al-Nbaheen, M. and Vishnubalaji, R. and Ali, D. and Bouslimi, A. and Al-Jassir, F. and Megges, M. and Prigione, A. and Adjaye, J. and Kassem, M. and Aldahmash, A.
Stem Cell Reviews and Reports 9 (1): 32-43. February 2013

OCT4 and the acquisition of oocyte developmental competence during folliculogenesis.
Zuccotti, M. and Merico, V. and Belli, M. and Mulas, F. and Sacchi, L. and Zupan, B. and Redi, C.A. and Prigione, A. and Adjaye, J. and Bellazzi, R. and Garagna, S.
International Journal of Developmental Biology 56 (10-12): 853-858. 2012

Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations.
Prigione, A. and Hossini, A.M. and Lichtner, B. and Serin, A. and Fauler, B. and Megges, M. and Lurz, R. and Lehrach, H. and Makrantonaki, E. and Zouboulis, C.C and Adjaye, J.
PLoS ONE 6 (11): e27352. 14 November 2011

Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming.
Prigione, A. and Lichtner, B. and Kuhl, H. and Struys, E.A. and Wamelink, M. and Lehrach, H. and Ralser, M. and Timmermann, B. and Adjaye, J.
Stem Cells 29 (9): 1338-1348. September 2011

Molecular insights into reprogramming-initiation events mediated by the OSKM gene regulatory network.
Mah, N. and Wang, Y. and Liao, M.C. and Prigione, A. and Jozefczuk, J. and Lichtner, B. and Wolfrum, K. and Haltmeier, M. and Floettmann, M. and Schaefer, M. and Hahn, A. and Mrowka, R. and Klipp, E. and Andrade-Navarro, M.A. and Adjaye, J.
PLoS ONE 6 (8): e24351. 31 August 2011

Gatekeeper of pluripotency: a common Oct4 transcriptional network operates in mouse eggs and embryonic stem cells.
Zuccotti, M. and Merico, V. and Bellone, M. and Mulas, F. and Sacchi, L. and Rebuzzini, P. and Prigione, A. and Redi, C.A. and Bellazzi, R. and Adjaye, J. and Garagna, S.
BMC Genomics 12 : 345. 5 July 2011

Comparative analysis of human embryonic stem cell and induced pluripotent stem cell-derived hepatocyte-like cells reveals current drawbacks and possible strategies for improved differentiation.
Jozefczuk, J. and Prigione, A. and Chavez, L. and Adjaye, J.
Stem Cells and Development 20 (7): 1259-1275. July 2011

A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease.
Krueger, R. and Sharma, M. and Riess, O. and Gasser, T. and Van Broeckhoven, C. and Theuns, J. and Aasly, J. and Annesi, G. and Bentivoglio, A.R. and Brice, A. and Djarmati, A. and Elbaz, A. and Farrer, M. and Ferrarese, C. and Gibson, J.M. and Hadjigeorgiou, G.M. and Hattori, N. and Ioannidis, J.P.A. and Jasinska-Myga, B. and Klein, C. and Lambert, J.C. and Lesage, S. and Lin, J.J. and Lynch, T. and Mellick, G.D. and de Nigris, F. and Opala, G. and Prigione, A. and Quattrone, A. and Ross, O.A. and Satake, W. and Silburn, P.A. and Tan, E.K. and Toda, T. and Tomiyama, H. and Wirdefeldt, K. and Wszolek, Z. and Xiromerisiou, G. and Maraganore, D.M.
Neurobiology of Aging 32 (3): 548.e9-548.e18. March 2011

An ES-like pluripotent state in FGF-dependent murine iPS cells.
Di Stefano, B. and Buecker, C. and Ungaro, F. and Prigione, A. and Chen, H.H. and Welling, M. and Eijpe, M. and Mostoslavsky, G. and Tesar, P. and Adjaye, J. and Geijsen, N. and Broccoli, V.
PLoS ONE 5 (12): e16092. 30 December 2010

The LARGE principle of cellular reprogramming: lost, acquired and retained gene expression in foreskin and amniotic fluid-derived human iPS cells.
Wolfrum, K. and Wang, Y. and Prigione, A. and Sperling, K. and Lehrach, H. and Adjaye, J.
PLoS ONE 5 (10): e13703. 29 October 2010

Alpha-synuclein nitration and autophagy response are induced in peripheral blood cells from patients with Parkinson disease.
Prigione, A. and Piazza, F. and Brighina, L. and Begni, B. and Galbussera, A. and DiFrancesco, J.C. and Andreoni, S. and Piolti, R. and Ferrarese, C.
Neuroscience Letters 477 (1): 6-10. 14 June 2010

A transcriptional roadmap to the induction of pluripotency in somatic cells.
Wang, Y. and Mah, N. and Prigione, A. and Wolfrum, K. and Andrade-Navarro, M.A. and Adjaye, J.
Stem Cell Reviews 6 (2): 282-296. June 2010

Lymphomonocyte alpha-synuclein levels in aging and in Parkinson disease.
Brighina, L. and Prigione, A. and Begni, B. and Galbussera, A. and Andreoni, S. and Piolti, R. and Ferrarese, C.
Neurobiology of Aging 31 (5): 884-885. May 2010

The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells.
Prigione, A. and Fauler, B. and Lurz, R. and Lehrach, H. and Adjaye, J.
Stem Cells 28 (4): 721-733. April 2010

Modulation of mitochondrial biogenesis and bioenergetic metabolism upon in vitro and in vivo differentiation of human ES and iPS cells.
Prigione, A. and Adjaye, J.
International Journal of Developmental Biology 54 (11-12): 1729-1741. 2010

Efficient genetic reprogramming of unmodified somatic neural progenitors uncovers the essential requirement of Oct4 and Klf4.
Di Stefano, B. and Prigione, A. and Broccoli, V.
Stem Cells and Development 18 (5): 707-716. June 2009

Mitochondrial DNA deletions induce the adenosine monophosphate-activated protein kinase energy stress pathway and result in decreased secretion of some proteins.
Prigione, A. and Cortopassi, G.
Aging Cell 6 (5): 619-630. October 2007

Mitochondrial DNA deletions and chloramphenicol treatment stimulate the autophagic transcript ATG12.
Prigione, A. and Cortopassi, G.
Autophagy 3 (4): 377-380. July 2007

Mitochondrial DNA deletions inhibit proteasomal activity and stimulate an autophagic transcript.
Alemi, M. and Prigione, A. and Wong, A. and Schoenfeld, R. and DiMauro, S. and Hirano, M. and Taroni, F. and Cortopassi, G.
Free Radical Biology and Medicine 42 (1): 32-43. 1 January 2007

Oxidative stress in peripheral blood mononuclear cells from patients with Parkinson's disease: negative correlation with levodopa dosage.
Prigione, A. and Begni, B. and Galbussera, A. and Beretta, S. and Brighina, L. and Garofalo, R. and Andreoni, S. and Piolti, R. and Ferrarese, C.
Neurobiology of Disease 23 (1): 36-43. July 2006

"What do you remember about Chernobyl?" A new test of memory for media-mediated events.
Bizzozero, I. and Lucchelli, F. and Prigione, A. and Saetti, M.C. and Spinnler, H.
Neurological Sciences 25 (4): 205-215. October 2004

Review

Tackling mitochondrial diversity in brain function: from animal models to human brain organoids.
Menacho, C. and Prigione, A.
International Journal of Biochemistry and Cell Biology 123 : 105760. June 2020

Live-imaging readouts and cell models for phenotypic profiling of mitochondrial function.
Iannetti, E.F. and Prigione, A. and Smeitink, J.A.M. and Koopman, W.J.H. and Beyrath, J. and Renkema, H.
Frontiers in Genetics 10 : 131. March 2019

Mitochondria and the dynamic control of stem cell homeostasis.
Lisowski, P. and Kannan, P. and Mlody, B. and Prigione, A.
EMBO Reports 19 (5): e45432. 1 May 2018

Pluripotent stem cells for uncovering the role of mitochondria in human brain function and dysfunction.
Zink, A. and Priller, J. and Prigione, A.
Journal of Molecular Biology 430 (7): 891-903. 30 March 2018

Mitochondrial metabolism in early neural fate and its relevance for neuronal disease modeling.
Lorenz, C. and Prigione, A.
Current Opinion in Cell Biology 49 : 71-76. December 2017

Concise review: Induced pluripotent stem cell-based drug discovery for mitochondrial disease.
Inak, G. and Lorenz, C. and Lisowski, P. and Zink, A. and Mlody, B. and Prigione, A.
Stem Cells 35 (7): 1655-1662. July 2017

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway.
Stincone, A. and Prigione, A. and Cramer, T. and Wamelink, M.M.C. and Campbell, K. and Cheung, E. and Olin-Sandoval, V. and Gruening, N.M. and Krueger, A. and Tauqeer Alam, M. and Keller, M.A. and Breitenbach, M. and Brindle, K.M. and Rabinowitz, J.D. and Ralser, M.
Biological Reviews 90 (3): 927-963. August 2015

Metabolic restructuring and cell fate conversion.
Prigione, A. and Ruiz-Perez, M.V. and Bukowiecki, R. and Adjaye, J.
Cellular and Molecular Life Sciences 72 (9): 1759-1777. 1 May 2015

Human induced pluripotent stem cells--from mechanisms to clinical applications.
Drews, K. and Jozefczuk, J. and Prigione, A. and Adjaye, J.
Journal of Molecular Medicine 90 (7): 735-745. July 2012

Letter

Increased oxidative stress in lymphocytes from untreated Parkinson's disease patients.
Prigione, A. and Isaias, I.U. and Galbussera, A. and Brighina, L. and Begni, B. and Andreoni, S. and Pezzoli, G. and Antonini, A. and Ferrarese, C.
Parkinsonism & Related Disorders 15 (4): 327-328. May 2009

Editorial

A glycolytic solution for pluripotent stem cells.
Mlody, B. and Prigione, A.
Cell Stem Cell 19 (4): 419-420. 6 October 2016

A mitochondrial view of cell fate.
Prigione, A.
Seminars in Cell & Developmental Biology 52 : 66-67. April 2016

Comment

Aging vs. rejuvenation: reprogramming to iPSCs does not turn back the clock for somatic mitochondrial DNA mutations.
Lorenz, C. and Prigione, A.
Stem Cell Investigation 3 : 43. September 2016

A mitochondrial strategy for safeguarding the reprogrammed genome.
Prigione, A. and Adjaye, J.
Cell Regeneration 3 (1): 5. 29 March 2014

Preprint

Assessment of ethanol-induced toxicity on iPSC-derived human dopaminergic neurons using a novel high-throughput mitochondrial neuronal health (MNH) assay.
Zink, A. and Conrad, J. and Telugu, N.S. and Diecke, S. and Heinz, A. and Wanker, E.E. and Priller, J. and Prigione, A.
bioRxiv : 2020.08.12.237461. 12 August 2020

SURF1 mutations causative of Leigh syndrome impair human neurogenesis.
Inak, G. and Rybak-Wolf, A. and Lisowski, P. and Juettner, R. and Zink, A. and Mlody, B. and Glazar, P. and Secker, C. and Ciptasari, U.H. and Stenzel, W. and Hahn, T. and Diecke, S. and Priller, J. and Gotthardt, M. and Kuehn, R. and Wanker, E.E. and Rajewsky, N. and Schuelke, M. and Prigione, A.
bioRxiv : 551390. 20 February 2019

This list was generated on Thu Mar 28 02:22:51 2024 CET.
Open Access
MDC Library