Browse by Research Team

Annals of Neurology

Rare variants in GABA(A) receptor genes in Rolandic epilepsy and related syndromes.
Reinthaler, E.M., Dejanovic, B., Lal, D., Semtner, M., Merkler, Y., Reinhold, A., Pittrich, D.A., Hotzy, C., Feucht, M., Steinboeck, H., Gruber-Sedlmayr, U., Ronen, G., Neophytou, B., Geldner, J., Haberlandt, E., Muhle, H., Ikram, M.A., van Duijn, CM., Uitterlinden, A.G., Hofman, A., Altmüller, J., Kawalia, A., Toliat, M.R., Nuernberg, P., Lerche, H., Nothnagel, M., Thiele, H., Sander, T., Meier, J.C., Schwarz, G., Neubauer, B.A. and Zimprich, F.
Annals of Neurology 77 (6): 972-986. June 2015

Biochimica et Biophysica Acta - Biomembranes

Ensemble and single particle fluorimetric techniques in concerted action to study the diffusion and aggregation of the glycine receptor α3 isoforms in the cell plasma membrane.
Notelaers, K., Smisdom, N., Rocha, S., Janssen, D., Meier, J.C., Rigo, J.M., Hofkens, J. and Ameloot, M.
Biochimica et Biophysica Acta - Biomembranes 1818 (12): 3131-3140. December 2012

Biochimica et Biophysica Acta - Molecular Cell Research

Analysis of α3 GlyR single particle tracking in the cell membrane.
Notelaers, K., Rocha, S., Paesen, R., Smisdom, N., De Clercq, B., Meier, J.C., Rigo, J.M., Hofkens, J. and Ameloot, M.
Biochimica et Biophysica Acta - Molecular Cell Research 1843 (3): 544-553. March 2014

Brain

Irregular RNA splicing curtails postsynaptic gephyrin in the cornu ammonis of patients with epilepsy.
Foerstera, B., Belaidi, A.A., Juettner, R., Bernert, C., Tsokos, M., Lehmann, T.N., Horn, P., Dehnicke, C., Schwarz, G. and Meier, J.C.
Brain 133 (Pt12): 3778-3794. December 2010

Cell Death & Disease

Chloride transporter KCC2-dependent neuroprotection depends on the N-terminal protein domain.
Winkelmann, A., Semtner, M. and Meier, J.C.
Cell Death & Disease 6 : e1776. 4 June 2015

Cell Death and Differentiation

Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis.
Fossati, G., Morini, R., Corradini, I., Antonucci, F., Trepte, P., Edry, E., Sharma, V., Papale, A., Pozzi, D., Defilippi, P., Meier, J.C., Brambilla, R., Turco, E., Rosenblum, K., Wanker, E.E., Ziv, N.E., Menna, E. and Matteoli, M.
Cell Death and Differentiation 22 (9): 1425-1436. September 2015

Cell Stem Cell

Human iPSC-derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders.
Lorenz, C., Lesimple, P., Bukowiecki, R., Zink, A., Inak, G., Mlody, B., Singh, M., Semtner, M., Mah, N., Auré, K., Leong, M., Zabiegalov, O., Lyras, E.M., Pfiffer, V., Fauler, B., Eichhorst, J., Wiesner, B., Huebner, N., Priller, J., Mielke, T., Meierhofer, D., Izsvák, Z., Meier, J.C., Bouillaud, F., Adjaye, J., Schuelke, M., Wanker, E.E., Lombès, A. and Prigione, A.
Cell Stem Cell 20 (5): 659-674.e9. 4 May 2017

Cell and Tissue Research

The enigma of transmitter-selective receptor accumulation at developing inhibitory synapses.
Meier, J.
Cell and Tissue Research 311 (3): 271-276. March 2003

Cerebral Cortex

Identification of parvalbumin interneurons as cellular substrate of fear memory persistence.
Caliskan, G., Mueller, I., Semtner, M., Winkelmann, A., Raza, A.S., Hollnagel, J.O., Roesler, A., Heinemann, U., Stork, O. and Meier, J.C.
Cerebral Cortex 26 (5): 2325-2340. May 2016

European Journal of Neuroscience

Direct binding of GABA(A) receptor β2 and β3 subunits to gephyrin.
Kowalczyk, S., Winkelmann, A., Smolinsky, B., Foerstera, B., Neundorf, I., Schwarz, G. and Meier, J.C.
European Journal of Neuroscience 37 (4): 544-554. February 2013

Splice-specific roles of glycine receptor alpha3 in the hippocampus.
Eichler, S.A., Foerstera, B., Smolinsky, B., Juettner, R., Lehmann, T.N., Faehling, M., Schwarz, G., Legendre, P. and Meier, J.C.
European Journal of Neuroscience 30 (6): 1077-1091. September 2009

GluR- and TrkB-mediated maturation of GABA receptor function during the period of eye opening.
Henneberger, C., Juettner, R., Schmidt, S.A., Walter, J., Meier, J.C., Rothe, T. and Grantyn, R.
European Journal of Neuroscience 21 (2): 431-440. January 2005

Slow IPSC kinetics, low levels of alpha1 subunit expression and paired-pulse depression are distinct properties of neonatal inhibitory GABAergic synaptic connections in the mouse superior colliculus.
Juettner, R., Meier, J. and Grantyn, R.
European Journal of Neuroscience 13 (11): 2088-2098. June 2001

European Journal of Pharmacology

New insights in endogenous modulation of ligand-gated ion channels: histamine is an inverse agonist at strychnine sensitive glycine receptors.
Kletke, O., Sergeeva, O.A., Lorenz, P., Oberland, S., Meier, J.C., Hatt, H. and Gisselmann, G.
European Journal of Pharmacology 710 (1-3): 59-66. 15 June 2013

Frontiers in Cellular Neuroscience

Presynaptic mechanisms of neuronal plasticity and their role in epilepsy.
Meier, J.C., Semtner, M., Winkelmann, A. and Wolfart, J.
Frontiers in Cellular Neuroscience 8 : 164. 17 June 2014

Functional hallmarks of GABAergic synapse maturation and the diverse roles of neurotrophins.
Grantyn, R., Henneberger, C., Juettner, R., Meier, J.C. and Kirischuk, S.
Frontiers in Cellular Neuroscience 5 : 13. 4 July 2011

Frontiers in Molecular Neuroscience

Frontiers in molecular neuroscience - resume and perspective.
Meier, J.C., Harvey, R.J. and Seeburg, P.
Frontiers in Molecular Neuroscience 4 : 58. December 2011

Phorbol-ester mediated suppression of hASH1 synthesis: multiple ways to keep the level down.
Benko, E., Winkelmann, A., Meier, J.C., Persson, P.B., Scholz, H. and Faehling, M.
Frontiers in Molecular Neuroscience 4 : 1. 2011

Genetic techniques and circuit analysis.
Wisden, W. and Meier, J.C.
Frontiers in Molecular Neuroscience 3 (3): 4. 3 March 2010

Glycine receptors caught between genome and proteome – Functional implications of RNA editing and splicing.
Legendre, P., Foerstera, B., Juettner, R. and Meier, J.C.
Frontiers in Molecular Neuroscience 2 : 23. 9 November 2009

E-I balance and human diseases - from molecules to networking.
Eichler, S.A. and Meier, J.C.
Frontiers in Molecular Neuroscience 1 (2) 28 March 2008

Frontiers in Neural Circuits

Reduced tonic inhibition in striatal output neurons from Huntington mice due to loss of astrocytic GABA release through GAT-3.
Wojtowicz, A.M., Dvorzhak, A., Semtner, M. and Grantyn, R.
Frontiers in Neural Circuits 7 : 188. 26 November 2013

Histochemistry and Cell Biology

Membrane distribution of the glycine receptor α3 studied by optical super-resolution microscopy.
Notelaers, K., Rocha, S., Paesen, R., Swinnen, N., Vangindertael, J., Meier, J.C., Rigo, J.M., Ameloot, M. and Hofkens, J.
Histochemistry and Cell Biology 142 (1): 79-90. July 2014

Journal of Biological Chemistry

Shutdown of achaete-scute homolog-1 expression by heterogeneous nuclear ribonucleoprotein (hnRNP)-A2/B1 in hypoxia.
Kasim, M., Benko, E., Winkelmann, A., Mrowka, R., Staudacher, J.J., Persson, P.B., Scholz, H., Meier, J.C. and Fahling, M.
Journal of Biological Chemistry 289 (39): 26973-26988. 26 September 2014

Translational regulation of the human achaete-scute homologue-1 (hASH1) by fragile x-mental retardation protein (FMRP).
Faehling, M., Mrowka, R., Steege, A., Kirschner, K.M., Benko, E., Foerstera, B., Persson, P.B., Thiele, B.J., Meier, J.C. and Scholz, H.
Journal of Biological Chemistry 284 (7): 4255-4266. 13 February 2009

Splice-specific functions of gephyrin in molybdenum cofactor biosynthesis.
Smolinsky, B., Eichler, S.A., Burchmeier, S., Meier, J.C. and Schwarz, G.
Journal of Biological Chemistry 283 (25): 17370-17379. 20 June 2008

Journal of Cell Science

Intracellular glycine receptor function facilitates glioma formation in vivo.
Förstera, B., a Dzaye, O.D., Winkelmann, A., Semtner, M., Benedetti, B., Markovic, D.S., Synowitz, M., Wend, P., Fähling, M., Junier, M.P., Glass, R., Kettenmann, H. and Meier, J.C.
Journal of Cell Science 127 (Pt 17): 3687-3698. 1 September 2014

Vertebrate-specific sequences in the gephyrin E-domain regulate cytosolic aggregation and postsynaptic clustering.
Lardi-Studler, B., Smolinsky, B., Petitjean, C.M., Koenig, F., Sidler, C., Meier, J.C., Fritschy, J.M. and Schwarz, G.
Journal of Cell Science 120 (Pt 8): 1371-1382. 15 April 2007

Formation of glycine receptor clusters and their accumulation at synapses.
Meier, J., Meunier-Durmort, C., Forest, C., Triller, A. and Vannier, C.
Journal of Cell Science 113 (Pt 15): 2783-2795. August 2000

Journal of Cellular and Molecular Medicine

Glycinergic tonic inhibition of hippocampal neurons with depolarizing GABAergic transmission elicits histopathological signs of temporal lobe epilepsy.
Eichler, S.A., Kirischuk, S., Juettner, R., Schaefermeier, P.K., Legendre, P., Lehmann, T.N., Gloveli, T., Grantyn, R. and Meier, J.C.
Journal of Cellular and Molecular Medicine 12 (6b): 2848-2866. December 2008

Journal of Clinical Investigation

Changes in neural network homeostasis trigger neuropsychiatric symptoms.
Winkelmann, A., Maggio, N., Eller, J., Caliskan, G., Semtner, M., Häussler, U., Jüttner, R., Dugladze, T., Smolinsky, B., Kowalczyk, S., Chronowska, E., Schwarz, G., Rathjen, F.G., Rechavi, G., Haas, C.A., Kulik, A., Gloveli, T., Heinemann, U. and Meier, J.C.
Journal of Clinical Investigation 124 (2): 696-711. 3 February 2014

Journal of Molecular Medicine

Transferrin-receptor-mediated iron accumulation controls proliferation and glutamate release in glioma cells.
Chirasani, S.R., Markovic, D.S., Synowitz, M., Eichler, S.A., Wisniewski, P., Kaminska, B., Otto, A., Wanker, E., Schaefer, M., Chiarugi, P., Meier, J.C., Kettenmann, H. and Glass, R.
Journal of Molecular Medicine 87 (2): 153-167. February 2009

Journal of Neuroscience

Altered balance of glutamatergic/GABAergic synaptic input and associated changes in dendrite morphology after BDNF expression in BDNF-deficient hippocampal neurons.
Singh, B., Henneberger, C., Betances, D., Arevalo, M.A., Rodriguez-Tebar, A., Meier, J.C. and Grantyn, R.
Journal of Neuroscience 26 (27): 7189-7200. 5 July 2006

A gephyrin-related mechanism restraining glycine receptor anchoring at GABAergic synapses.
Meier, J. and Grantyn, R.
Journal of Neuroscience 24 (6): 1398-1405. 11 February 2004

Dynamics of glycine receptor insertion in the neuronal plasma membrane.
Rosenberg, M., Meier, J., Triller, A. and Vannier, C.
Journal of Neuroscience 21 (14): 5036-5044. 15 July 2001

Journal of Physiology

Preferential accumulation of GABAA receptor gamma 2L, not gamma 2S, cytoplasmic loops at rat spinal cord inhibitory synapses.
Meier, J. and Grantyn, R.
Journal of Physiology 559 (Pt 2): 355-365. 2004

Molecular Biology of the Cell

NGF controls dendrite development in hippocampal neurons by binding to p75NTR and modulating the cellular targets of Notch.
Salama-Cohen, P., Arevalo, M.A., Meier, J., Grantyn, R. and Rodríguez-Tebar, A.
Molecular Biology of the Cell 16 (1): 339-347. January 2005

Molecular Pharmacology

Desensitization of homomeric alpha1 glycine receptor increases with receptor density.
Legendre, P., Muller, E., Badiu, C.I., Meier, J., Vannier, C. and Triller, A.
Molecular Pharmacology 62 (4): 817-827. October 2002

Molecular Syndromology

Hippocampal characteristics and invariant sequence elements distribution of GLRA2 and GLRA3 C-to-U editing.
Schaefermeier, P. and Heinze, S.
Molecular Syndromology 8 (2): 85-92. March 2017

Molecular and Cellular Neuroscience

GABA(A) receptor activity and PKC control inhibitory synaptogenesis in CNS tissue slices.
Meier, J., Akyeli, J., Kirischuk, S. and Grantyn, R.
Molecular and Cellular Neuroscience 23 (4): 600-613. August 2003

Synaptic anchoring of glycine receptors in developing collicular neurons under control of metabotropic glutamate receptor activity.
Meier, J., Juettner, R., Kirischuk, S. and Grantyn, R.
Molecular and Cellular Neuroscience 21 (2): 324-340. October 2002

Functional heterogeneity of gephyrins.
Meier, J., De Chaldee, M., Triller, A. and Vannier, C.
Molecular and Cellular Neuroscience 16 (5): 566-577. November 2000

Nature Neuroscience

RNA editing produces glycine receptor alpha3(P185L), resulting in high agonist potency.
Meier, J.C., Henneberger, C., Melnick, I., Racca, C., Harvey, R.J., Heinemann, U., Schmieden, V. and Grantyn, R.
Nature Neuroscience 8 (6): 736-744. June 2005

Fast and reversible trapping of surface glycine receptors by gephyrin.
Meier, J., Vannier, C., Serge, A., Triller, A. and Choquet, D.
Nature Neuroscience 4 (3): 253-260. March 2001

NeuroReport

Inhibition of alpha-subunit glycine receptors by quinoxalines.
Meier, J. and Schmieden, V.
NeuroReport 14 (11): 1507-1510. 6 August 2003

Neuron

Impaired synapse function during postnatal development in the absence of CALEB, an EGF-like protein processed by neuronal activity.
Juettner, R., More, M.I., Das, D., Babich, A., Meier, J., Henning, M., Erdmann, B., Mueller, E.C., Otto, A., Grantyn, R. and Rathjen, F.G.
Neuron 46 (2): 233-245. 21 May 2005

Nucleic Acids Research

Hypoxia-induced gene expression results from selective mRNA partitioning to the endoplasmic reticulum.
Staudacher, J.J., Naarmann-de Vries, I.S., Ujvari, S.J., Klinger, B., Kasim, M., Benko, E., Ostareck-Lederer, A., Ostareck, D.H., Bondke Persson, A., Lorenzen, S., Meier, J.C., Blüthgen, N., Persson, P.B., Henrion-Caude, A., Mrowka, R. and Faehling, M.
Nucleic Acids Research 43 (6): 3219-3236. 31 March 2015

PLoS Biology

Palmitoylation of gephyrin controls receptor clustering and plasticity of GABAergic synapses.
Dejanovic, B., Semtner, M., Ebert, S., Lamkemeyer, T., Neuser, F., Luescher, B., Meier, J.C. and Schwarz, G.
PLoS Biology 12 (7): e1001908. 15 July 2014

PLoS ONE

Identification of a new genomic hot spot of evolutionary diversification of protein function.
Winkelmann, A., You, X., Gruenewald, N., Haeussler, U., Krestel, H., Haas, C.A., Schwarz, G., Chen, W. and Meier, J.C.
PLoS ONE 10 (5): e0125413. 8 May 2015

Proceedings of the National Academy of Sciences of the United States of America

GABA(B) autoreceptor-mediated cell type-specific reduction of inhibition in epileptic mice.
Dugladze, T., Maziashvili, N., Boergers, C., Gurgenidze, S., Haeussler, U., Winkelmann, A., Haas, C.A., Meier, J.C., Vida, I., Kopell, N.J. and Gloveli, T.
Proceedings of the National Academy of Sciences of the United States of America 110 (37): 15073-15078. 10 September 2013