Browse by Research Team

2017

Human iPSC-derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders.
Lorenz, C. and Lesimple, P. and Bukowiecki, R. and Zink, A. and Inak, G. and Mlody, B. and Singh, M. and Semtner, M. and Mah, N. and Auré, K. and Leong, M. and Zabiegalov, O. and Lyras, E.M. and Pfiffer, V. and Fauler, B. and Eichhorst, J. and Wiesner, B. and Huebner, N. and Priller, J. and Mielke, T. and Meierhofer, D. and Izsvák, Z. and Meier, J.C. and Bouillaud, F. and Adjaye, J. and Schuelke, M. and Wanker, E.E. and Lombès, A. and Prigione, A.
Cell Stem Cell 20 (5): 659-674.e9. 4 May 2017

Hippocampal characteristics and invariant sequence elements distribution of GLRA2 and GLRA3 C-to-U editing.
Schaefermeier, P. and Heinze, S.
Molecular Syndromology 8 (2): 85-92. March 2017

2016

Identification of parvalbumin interneurons as cellular substrate of fear memory persistence.
Caliskan, G. and Mueller, I. and Semtner, M. and Winkelmann, A. and Raza, A.S. and Hollnagel, J.O. and Roesler, A. and Heinemann, U. and Stork, O. and Meier, J.C.
Cerebral Cortex 26 (5): 2325-2340. May 2016

2015

Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis.
Fossati, G. and Morini, R. and Corradini, I. and Antonucci, F. and Trepte, P. and Edry, E. and Sharma, V. and Papale, A. and Pozzi, D. and Defilippi, P. and Meier, J.C. and Brambilla, R. and Turco, E. and Rosenblum, K. and Wanker, E.E. and Ziv, N.E. and Menna, E. and Matteoli, M.
Cell Death and Differentiation 22 (9): 1425-1436. September 2015

Chloride transporter KCC2-dependent neuroprotection depends on the N-terminal protein domain.
Winkelmann, A. and Semtner, M. and Meier, J.C.
Cell Death & Disease 6 : e1776. 4 June 2015

Rare variants in GABA(A) receptor genes in Rolandic epilepsy and related syndromes.
Reinthaler, E.M. and Dejanovic, B. and Lal, D. and Semtner, M. and Merkler, Y. and Reinhold, A. and Pittrich, D.A. and Hotzy, C. and Feucht, M. and Steinboeck, H. and Gruber-Sedlmayr, U. and Ronen, G. and Neophytou, B. and Geldner, J. and Haberlandt, E. and Muhle, H. and Ikram, M.A. and van Duijn, CM. and Uitterlinden, A.G. and Hofman, A. and Altmüller, J. and Kawalia, A. and Toliat, M.R. and Nuernberg, P. and Lerche, H. and Nothnagel, M. and Thiele, H. and Sander, T. and Meier, J.C. and Schwarz, G. and Neubauer, B.A. and Zimprich, F.
Annals of Neurology 77 (6): 972-986. June 2015

Identification of a new genomic hot spot of evolutionary diversification of protein function.
Winkelmann, A. and You, X. and Gruenewald, N. and Haeussler, U. and Krestel, H. and Haas, C.A. and Schwarz, G. and Chen, W. and Meier, J.C.
PLoS ONE 10 (5): e0125413. 8 May 2015

Hypoxia-induced gene expression results from selective mRNA partitioning to the endoplasmic reticulum.
Staudacher, J.J. and Naarmann-de Vries, I.S. and Ujvari, S.J. and Klinger, B. and Kasim, M. and Benko, E. and Ostareck-Lederer, A. and Ostareck, D.H. and Bondke Persson, A. and Lorenzen, S. and Meier, J.C. and Blüthgen, N. and Persson, P.B. and Henrion-Caude, A. and Mrowka, R. and Faehling, M.
Nucleic Acids Research 43 (6): 3219-3236. 31 March 2015

2014

Shutdown of achaete-scute homolog-1 expression by heterogeneous nuclear ribonucleoprotein (hnRNP)-A2/B1 in hypoxia.
Kasim, M. and Benko, E. and Winkelmann, A. and Mrowka, R. and Staudacher, J.J. and Persson, P.B. and Scholz, H. and Meier, J.C. and Fahling, M.
Journal of Biological Chemistry 289 (39): 26973-26988. 26 September 2014

Intracellular glycine receptor function facilitates glioma formation in vivo.
Förstera, B. and a Dzaye, O.D. and Winkelmann, A. and Semtner, M. and Benedetti, B. and Markovic, D.S. and Synowitz, M. and Wend, P. and Fähling, M. and Junier, M.P. and Glass, R. and Kettenmann, H. and Meier, J.C.
Journal of Cell Science 127 (Pt 17): 3687-3698. 1 September 2014

Palmitoylation of gephyrin controls receptor clustering and plasticity of GABAergic synapses.
Dejanovic, B. and Semtner, M. and Ebert, S. and Lamkemeyer, T. and Neuser, F. and Luescher, B. and Meier, J.C. and Schwarz, G.
PLoS Biology 12 (7): e1001908. 15 July 2014

Membrane distribution of the glycine receptor α3 studied by optical super-resolution microscopy.
Notelaers, K. and Rocha, S. and Paesen, R. and Swinnen, N. and Vangindertael, J. and Meier, J.C. and Rigo, J.M. and Ameloot, M. and Hofkens, J.
Histochemistry and Cell Biology 142 (1): 79-90. July 2014

Presynaptic mechanisms of neuronal plasticity and their role in epilepsy.
Meier, J.C. and Semtner, M. and Winkelmann, A. and Wolfart, J.
Frontiers in Cellular Neuroscience 8 : 164. 17 June 2014

Analysis of α3 GlyR single particle tracking in the cell membrane.
Notelaers, K. and Rocha, S. and Paesen, R. and Smisdom, N. and De Clercq, B. and Meier, J.C. and Rigo, J.M. and Hofkens, J. and Ameloot, M.
Biochimica et Biophysica Acta - Molecular Cell Research 1843 (3): 544-553. March 2014

Changes in neural network homeostasis trigger neuropsychiatric symptoms.
Winkelmann, A. and Maggio, N. and Eller, J. and Caliskan, G. and Semtner, M. and Häussler, U. and Jüttner, R. and Dugladze, T. and Smolinsky, B. and Kowalczyk, S. and Chronowska, E. and Schwarz, G. and Rathjen, F.G. and Rechavi, G. and Haas, C.A. and Kulik, A. and Gloveli, T. and Heinemann, U. and Meier, J.C.
Journal of Clinical Investigation 124 (2): 696-711. 3 February 2014

2013

Reduced tonic inhibition in striatal output neurons from Huntington mice due to loss of astrocytic GABA release through GAT-3.
Wojtowicz, A.M. and Dvorzhak, A. and Semtner, M. and Grantyn, R.
Frontiers in Neural Circuits 7 : 188. 26 November 2013

GABA(B) autoreceptor-mediated cell type-specific reduction of inhibition in epileptic mice.
Dugladze, T. and Maziashvili, N. and Boergers, C. and Gurgenidze, S. and Haeussler, U. and Winkelmann, A. and Haas, C.A. and Meier, J.C. and Vida, I. and Kopell, N.J. and Gloveli, T.
Proceedings of the National Academy of Sciences of the United States of America 110 (37): 15073-15078. 10 September 2013

New insights in endogenous modulation of ligand-gated ion channels: histamine is an inverse agonist at strychnine sensitive glycine receptors.
Kletke, O. and Sergeeva, O.A. and Lorenz, P. and Oberland, S. and Meier, J.C. and Hatt, H. and Gisselmann, G.
European Journal of Pharmacology 710 (1-3): 59-66. 15 June 2013

Direct binding of GABA(A) receptor β2 and β3 subunits to gephyrin.
Kowalczyk, S. and Winkelmann, A. and Smolinsky, B. and Foerstera, B. and Neundorf, I. and Schwarz, G. and Meier, J.C.
European Journal of Neuroscience 37 (4): 544-554. February 2013

2012

Ensemble and single particle fluorimetric techniques in concerted action to study the diffusion and aggregation of the glycine receptor α3 isoforms in the cell plasma membrane.
Notelaers, K. and Smisdom, N. and Rocha, S. and Janssen, D. and Meier, J.C. and Rigo, J.M. and Hofkens, J. and Ameloot, M.
Biochimica et Biophysica Acta - Biomembranes 1818 (12): 3131-3140. December 2012

2011

Frontiers in molecular neuroscience - resume and perspective.
Meier, J.C. and Harvey, R.J. and Seeburg, P.
Frontiers in Molecular Neuroscience 4 : 58. December 2011

Functional hallmarks of GABAergic synapse maturation and the diverse roles of neurotrophins.
Grantyn, R. and Henneberger, C. and Juettner, R. and Meier, J.C. and Kirischuk, S.
Frontiers in Cellular Neuroscience 5 : 13. 4 July 2011

Phorbol-ester mediated suppression of hASH1 synthesis: multiple ways to keep the level down.
Benko, E. and Winkelmann, A. and Meier, J.C. and Persson, P.B. and Scholz, H. and Faehling, M.
Frontiers in Molecular Neuroscience 4 : 1. 2011

2010

Irregular RNA splicing curtails postsynaptic gephyrin in the cornu ammonis of patients with epilepsy.
Foerstera, B. and Belaidi, A.A. and Juettner, R. and Bernert, C. and Tsokos, M. and Lehmann, T.N. and Horn, P. and Dehnicke, C. and Schwarz, G. and Meier, J.C.
Brain 133 (Pt12): 3778-3794. December 2010

Genetic techniques and circuit analysis.
Wisden, W. and Meier, J.C.
Frontiers in Molecular Neuroscience 3 (3): 4. 3 March 2010

2009

Glycine receptors caught between genome and proteome – Functional implications of RNA editing and splicing.
Legendre, P. and Foerstera, B. and Juettner, R. and Meier, J.C.
Frontiers in Molecular Neuroscience 2 : 23. 9 November 2009

Splice-specific roles of glycine receptor alpha3 in the hippocampus.
Eichler, S.A. and Foerstera, B. and Smolinsky, B. and Juettner, R. and Lehmann, T.N. and Faehling, M. and Schwarz, G. and Legendre, P. and Meier, J.C.
European Journal of Neuroscience 30 (6): 1077-1091. September 2009

Translational regulation of the human achaete-scute homologue-1 (hASH1) by fragile x-mental retardation protein (FMRP).
Faehling, M. and Mrowka, R. and Steege, A. and Kirschner, K.M. and Benko, E. and Foerstera, B. and Persson, P.B. and Thiele, B.J. and Meier, J.C. and Scholz, H.
Journal of Biological Chemistry 284 (7): 4255-4266. 13 February 2009

Transferrin-receptor-mediated iron accumulation controls proliferation and glutamate release in glioma cells.
Chirasani, S.R. and Markovic, D.S. and Synowitz, M. and Eichler, S.A. and Wisniewski, P. and Kaminska, B. and Otto, A. and Wanker, E. and Schaefer, M. and Chiarugi, P. and Meier, J.C. and Kettenmann, H. and Glass, R.
Journal of Molecular Medicine 87 (2): 153-167. February 2009

2008

Glycinergic tonic inhibition of hippocampal neurons with depolarizing GABAergic transmission elicits histopathological signs of temporal lobe epilepsy.
Eichler, S.A. and Kirischuk, S. and Juettner, R. and Schaefermeier, P.K. and Legendre, P. and Lehmann, T.N. and Gloveli, T. and Grantyn, R. and Meier, J.C.
Journal of Cellular and Molecular Medicine 12 (6b): 2848-2866. December 2008

Splice-specific functions of gephyrin in molybdenum cofactor biosynthesis.
Smolinsky, B. and Eichler, S.A. and Burchmeier, S. and Meier, J.C. and Schwarz, G.
Journal of Biological Chemistry 283 (25): 17370-17379. 20 June 2008

E-I balance and human diseases - from molecules to networking.
Eichler, S.A. and Meier, J.C.
Frontiers in Molecular Neuroscience 1 (2) 28 March 2008

2007

Vertebrate-specific sequences in the gephyrin E-domain regulate cytosolic aggregation and postsynaptic clustering.
Lardi-Studler, B. and Smolinsky, B. and Petitjean, C.M. and Koenig, F. and Sidler, C. and Meier, J.C. and Fritschy, J.M. and Schwarz, G.
Journal of Cell Science 120 (Pt 8): 1371-1382. 15 April 2007

2006

Altered balance of glutamatergic/GABAergic synaptic input and associated changes in dendrite morphology after BDNF expression in BDNF-deficient hippocampal neurons.
Singh, B. and Henneberger, C. and Betances, D. and Arevalo, M.A. and Rodriguez-Tebar, A. and Meier, J.C. and Grantyn, R.
Journal of Neuroscience 26 (27): 7189-7200. 5 July 2006

Protein kinases and synaptogenesis.
Meier, J.C.
In: Molecular Mechanisms of Synaptogenesis. Springer, 311-332. ISBN 0-387-32560-3 2006

2005

RNA editing produces glycine receptor alpha3(P185L), resulting in high agonist potency.
Meier, J.C. and Henneberger, C. and Melnick, I. and Racca, C. and Harvey, R.J. and Heinemann, U. and Schmieden, V. and Grantyn, R.
Nature Neuroscience 8 (6): 736-744. June 2005

Impaired synapse function during postnatal development in the absence of CALEB, an EGF-like protein processed by neuronal activity.
Juettner, R. and More, M.I. and Das, D. and Babich, A. and Meier, J. and Henning, M. and Erdmann, B. and Mueller, E.C. and Otto, A. and Grantyn, R. and Rathjen, F.G.
Neuron 46 (2): 233-245. 21 May 2005

GluR- and TrkB-mediated maturation of GABA receptor function during the period of eye opening.
Henneberger, C. and Juettner, R. and Schmidt, S.A. and Walter, J. and Meier, J.C. and Rothe, T. and Grantyn, R.
European Journal of Neuroscience 21 (2): 431-440. January 2005

NGF controls dendrite development in hippocampal neurons by binding to p75NTR and modulating the cellular targets of Notch.
Salama-Cohen, P. and Arevalo, M.A. and Meier, J. and Grantyn, R. and Rodríguez-Tebar, A.
Molecular Biology of the Cell 16 (1): 339-347. January 2005

2004

A gephyrin-related mechanism restraining glycine receptor anchoring at GABAergic synapses.
Meier, J. and Grantyn, R.
Journal of Neuroscience 24 (6): 1398-1405. 11 February 2004

From synapses to maps: Development and use-dependent modification of synaptic connections in the visual layers of the rodent superior colliculus.
Grantyn, R. and Juettner, R. and Meier, J.
In: Methods and New Frontiers in Neuroscience: The superior colliculus. CRC Press, 173-210. 2004

Preferential accumulation of GABAA receptor gamma 2L, not gamma 2S, cytoplasmic loops at rat spinal cord inhibitory synapses.
Meier, J. and Grantyn, R.
Journal of Physiology 559 (Pt 2): 355-365. 2004

2003

Inhibition of alpha-subunit glycine receptors by quinoxalines.
Meier, J. and Schmieden, V.
NeuroReport 14 (11): 1507-1510. 6 August 2003

GABA(A) receptor activity and PKC control inhibitory synaptogenesis in CNS tissue slices.
Meier, J. and Akyeli, J. and Kirischuk, S. and Grantyn, R.
Molecular and Cellular Neuroscience 23 (4): 600-613. August 2003

The enigma of transmitter-selective receptor accumulation at developing inhibitory synapses.
Meier, J.
Cell and Tissue Research 311 (3): 271-276. March 2003

2002

Desensitization of homomeric alpha1 glycine receptor increases with receptor density.
Legendre, P. and Muller, E. and Badiu, C.I. and Meier, J. and Vannier, C. and Triller, A.
Molecular Pharmacology 62 (4): 817-827. October 2002

Synaptic anchoring of glycine receptors in developing collicular neurons under control of metabotropic glutamate receptor activity.
Meier, J. and Juettner, R. and Kirischuk, S. and Grantyn, R.
Molecular and Cellular Neuroscience 21 (2): 324-340. October 2002

2001

Dynamics of glycine receptor insertion in the neuronal plasma membrane.
Rosenberg, M. and Meier, J. and Triller, A. and Vannier, C.
Journal of Neuroscience 21 (14): 5036-5044. 15 July 2001

Slow IPSC kinetics, low levels of alpha1 subunit expression and paired-pulse depression are distinct properties of neonatal inhibitory GABAergic synaptic connections in the mouse superior colliculus.
Juettner, R. and Meier, J. and Grantyn, R.
European Journal of Neuroscience 13 (11): 2088-2098. June 2001

Fast and reversible trapping of surface glycine receptors by gephyrin.
Meier, J. and Vannier, C. and Serge, A. and Triller, A. and Choquet, D.
Nature Neuroscience 4 (3): 253-260. March 2001

2000

Functional heterogeneity of gephyrins.
Meier, J. and De Chaldee, M. and Triller, A. and Vannier, C.
Molecular and Cellular Neuroscience 16 (5): 566-577. November 2000

Formation of glycine receptor clusters and their accumulation at synapses.
Meier, J. and Meunier-Durmort, C. and Forest, C. and Triller, A. and Vannier, C.
Journal of Cell Science 113 (Pt 15): 2783-2795. August 2000