Browse by Research Team

AIDS-Forschung

Vergleichende Untersuchungen zu den Wirkungs- und Toxizitaetsunterschieden der HIV-RT Hemmstoffe 3`-Fluor-5-chlordesoxyridin (FCU) und 3`-Fluorthymidin.
Matthes, E. and Grade, G.
AIDS-Forschung 9 : 584. 1 January 1994

ELISA for the quantification of HIV-1 env glycoprotein 120: some practical applications.
Ushijima, H., Mangel, A., Forrest, J.M.S., Kunisada, T., Matthes, E. and Mueller, W.E.G.
AIDS-Forschung 7 : 185-189. 1 January 1992

Anti-Cancer Drug Design

Potential suitability of Na+/K+ -transporting ATPase in pre-screens for anti-cancer agents.
Repke, K.R.H., Schoen, R., Megges, R., Weiland, J., Nissen, E. and Matthes, E.
Anti-Cancer Drug Design 10 : 177-187. 1 January 1995

Anticancer Research

Up-regulation of telomerase activity in Herpesvirus saimiri immortalized human T-lymphocytes.
Harnack, U., Lehmann, C., Matthes, E. and Pecher, G.
Anticancer Research 21 : 3969-3972. 1 January 2001

Antimicrobial Agents and Chemotherapy

Cellular pharmacology of the anti-hepatitis B virus agent beta-L-2',3'-didehydro-2',3'-dideoxy-N4-hydroxycytidine: relevance for activation in HepG2 cells.
Matthes, E. and Buenger, H.
Antimicrobial Agents and Chemotherapy 54 (1): 341-345. 16 January 2010

Strong and selective inhibitors of HBV-replication between novel N4-hydroxy-and 5-methyl-beta-L-deoxycytidine analogues.
Matthes, E., Funk, A., Krahn, I., Gaertner, K., von Janta-Lipinski, M., Lin, L., Will, H. and Sirma, H.
Antimicrobial Agents and Chemotherapy 51 (7): 2523-2530. July 2007

Inhibition of duck hepatitis B virus replication by 2',3'-Dideoxy-3'-Fluoroguanosine in vitro and in vivo.
Hafkemeyer, P., Keppler-Hafkemeyer, A., al Haya, M.A., von Janta-Lipinski, M., Matthes, E., Lehmann, C., Offensperger, W.B., Offensperger, S., Gerok, W. and Blum, H.E.
Antimicrobial Agents and Chemotherapy 40 : 792-794. 1 January 1996

Comparative inhibition of hepatitis B virus and DNA polymerase and cellular DNA polymerases by triphosphates of sugar-modified 5-methyldeoxycytidines and other nucleoside analogs.
Matthes, E., Reimer, K., von Janta-Lipinski, M., Meisel, H. and Lehmann, C.
Antimicrobial Agents and Chemotherapy 36 : 1254-1257. 1 January 1991

Antiviral Chemistry & Chemotherapy

Inhibition of hepatitis B virus DNA polymerase by thymidine triphosphate analogues in vitro.
Reimer, K., Matthes, E., von Janta-Lipinski, M. and Meisel, H.
Antiviral Chemistry & Chemotherapy 1 : 249-253. 1 January 1991

Antiviral Chemistry and Chemotherapy

Side-chain derivatives of biologically active nucleosides. Part 2: Synthesis and anti-HIV activity of 5'-C-methyl derivatives of 3'-fluoro-3'-deoxythymidine.
Hiebl, J., Zbiral, E., von Janta-Lipinski, M., Balzarini, J. and De Clercq, E.
Antiviral Chemistry and Chemotherapy 7 : 173-177. 1 January 1996

Synergistic anti-human immunodeficiency viral (HIV-1) effect of the immunomodulator ampligen (mismatched double- stranded RNA) with inhibitors of reverse transcriptase and HIV-1 regulatory proteins.
Ushijima, H., Tsiapalis, C.M., Daum, T., Schroeder, H.C., Matthes, E., Engels, J.W., Mag, M., Muth, J. and Mueller, W.E.G.
Antiviral Chemistry and Chemotherapy 4 : 315-321. 1 January 1993

Antiviral Research

Inhibitory activity of 3'-fluoro 2' deoxythymidine and related nucleoside analogues against adenoviruses in vitro.
Mentel, R., Kinder, M., Wegner, U., von Janta-Lipinski, M. and Matthes, E.
Antiviral Research 34 : 113-119. 1 January 1997

Antiviral Therapy

Strong antiviral activity of the new l-hydroxycytidine derivative, l-Hyd4FC, in HBV-infected human chimeric uPA/SCID mice.
Volz, T., Luetgehetmann, M., Allweiss, L., Warlich, M., Bierwolf, J., Pollok, J.M., Petersen, J., Matthes, E. and Dandri, M.
Antiviral Therapy 17 (4): 623-631. 27 February 2012

Behring Institute Mitteilungen

Biochemical and genetical analysis of AZT-resistant HIV-mutants.
Biesert, L., Zimmermann, F., Schroeder, B., Matthes, E., Suhartono, H., Dietrich, U. and Rubsamen-Waigmann, H.
Behring Institute Mitteilungen 89 : 74-80. 1 January 1991

Biochemical Pharmacology

Inhibition of hepatitis B virus production by modified 2',3'-dideoxy-thymidine and 2',3'-dideoxy-5-methylcytidine derivatives. In vitro and in vivo studies.
Matthes, E., von Janta-Lipinski, M., Will, M., Schroeder, C., Merz, H., Steffen, R. and Mueller, W.E.G.
Biochemical Pharmacology 43 : 1571-1577. 1 January 1992

Biochimica et Biophysica Acta

Selective endocytosis of fluorothymidine and azidothymidine coupled to LDL into HIV infected mononuclear cells.
Mankertz, J., Matthes, E., Rokos, K., von Baeyer, H., Pauli, G. and Riedel, E.
Biochimica et Biophysica Acta 1317 : 233-237. 1 January 1996

Biological Chemistry

Real-time determination of telomerase activity in cell extracts using an optical biosensor.
Schmidt, P.M., Matthes, E., Scheller, F.W., Bienert, M., Lehmann, C., Ehrlich, A. and Bier, F.F.
Biological Chemistry 383 (10): 1659-1666. October 2002

Bioorganic and Medicinal Chemistry

Chemo-enzymatic synthesis of a new type of enantiomerically pure carbocyclic nucleoside analogues with strong inhibitory effects on terminal deoxynucleotidyl transferase.
Theil, F., Ballschuh, S., Flatau, S., von Janta-Lipinski, M. and Matthes, E.
Bioorganic and Medicinal Chemistry 6 : 701-706. 1 January 1998

Biosensors and Bioelectronics

Detection of activity of telomerase in tumor cells using fiber optical biosensors.
Schmidt, P.M., Lehmann, C., Matthes, E. and Bier, F.F.
Biosensors and Bioelectronics 17 (11-12): 1081-1087. December 2002

FEBS Letters

Selectivity of DNA polymerases toward alpha and beta nucleotide substrate of D and L series.
Semizarov, D.G., Victorova, L.S., Dyatkina, N.B., von Janta-Lipinski, M. and Krayevsky, A.A.
FEBS Letters 354 : 187-190. 1 January 1994

Gerontology

An improved method for determining telomere length and its use in assessing age in blood and saliva.
Lahnert, P.
Gerontology 51 (5): 352-356. 1 January 2005

Japanese Journal of Cancer Research

Inhibition of human immunodeficiency virus-1 infection by human conglutinin-like protein: in vitro studies.
Ushijima, H., Schroeder, H.C., Poznanovic, S., Gasic, M.J., Matthes, E. and Mueller, W.E.G.
Japanese Journal of Cancer Research 83 : 458-464. 1 January 1992

Journal of Enzyme Inhibition

Tamoxifen is a Na+-antagonistic inhibitor of Na+K+-transporting ATPase from tumour and normal cells.
Repke, K.R.H. and Matthes, E.
Journal of Enzyme Inhibition 8 : 207-212. 1 January 1994

Journal of Medicinal Chemistry

Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'- deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta and epsilon nor HIV-1 reverse transcriptase.
von Janta-Lipinski, M., Costisella, B., Ochs, H., Huebscher, U., Hafkemeyer, P. and Matthes, E.
Journal of Medicinal Chemistry 41 : 2040-2046. 1 January 1998

Journal of Virological Methods

Fluorescent focus reduction assay for the screening of antiadenoviral agents.
Mentel, R., Matthes, E., von Janta-Lipinski, M. and Wegner, U.
Journal of Virological Methods 59 : 99-104. 1 January 1996

Human immunodeficiency virus: novel enzyme-linked immunoassays for quantitation of envelope glycoprotein 120.
Weiler, B.E., Schaecke, H., Bachmann, M., Bridigo, L., Gilbert, M., Mills, J., Matthes, E., Forrest, J.M.S. and Mueller, W.E.G.
Journal of Virological Methods 32 : 287-301. 1 January 1991

Journal of the Chemical Society. Perkin Transactions 1

Chemoenzymatic synthesis of carbocyclic nucleoside analogues with bicyclo[3.1.0]hexyl residues.
Theil, F., Ballschuh, S., von Janta-Lipinski, M. and Johnson, R.A.
Journal of the Chemical Society. Perkin Transactions 1 1 : 255-258. 1 January 1996

Kidney International

Antisense oligodesoxynucleotide strategies in renal and cardiovascular disease.
Haller, H., Maasch, C., Dragun, D., Wellner, M., von Janta-Lipinski, M. and Luft, F.C.
Kidney International 53 : 1550-1558. 1 January 1998

Medical Microbiology and Immunology

Inhibition of adenovirus DNA polymerase by modified nucleoside triphosphate analogs correlate with their antiviral effects on cellular level.
Mentel, R., Kurek, S., Wegner, U., von Janta-Lipinski, M., Gurtler, L. and Matthes, E.
Medical Microbiology and Immunology 189 (2): 91-95. 1 November 2000

Nucleic Acids Research

Telomerase protein rather than its RNA is the target of phosphorothioate-modified oligonucleotides.
Matthes, E. and Lehmann, C.
Nucleic Acids Research 27 (4): 1152-1158. 15 February 1999

Nucleosides Nucleotides & Nucleic Acids

Protein and RNA of human telomerase as targets for modified oligonucleotides.
von Janta-Lipinski, M., Gaertner, K., Lehmann, C., Scheer, H., Schildt, J. and Matthes, E.
Nucleosides Nucleotides & Nucleic Acids 18 : 1719-1720. 1 January 1999

Reasons and limits of substrate activity of modified L-dNTP in DNA biosynthesis.
Krayevsky, A.A., Dyatkina, N.B., Semizarov, D.G., Victorova, L.S., Shirokova, E.A., Theil, F., von Janta-Lipinski, M., Gosselin, G. and Imbach, J.L.
Nucleosides Nucleotides & Nucleic Acids 18 : 863-864. 1 January 1999

Synthesis of four stereoisomers of carbocyclic 5'-NOR D4A and evaluation of their triphosphates as substrates for DNA polymerases.
Dyatkina, N., Semizarov, D., Victorova, L., Krayevsky, A., Theil, F. and von Janta-Lipinski, M.
Nucleosides Nucleotides & Nucleic Acids 14 : 723-726. 1 January 1995

Synthesis and anti-HIV activity of modified 2',3'-dideoxy- 3'-fluoro pyrimidine nucleosides.
von Janta-Lipinski, M., Gaertner, K., Schildt, E., Matthes, E., Scholz, D. and Langen, P.
Nucleosides Nucleotides & Nucleic Acids 10 : 651-652. 1 January 1991

Oligonucleotides

Potent inhibitory activity of chimeric oligonucleotides targeting two different sites of human telomerase.
Matthes, E., Lehmann, C., Stulich, M., Wu, Y., Dimitrova, L., Uhlmann, E. and Janta-Lipinski, M.V.
Oligonucleotides 15 (4): 255-268. December 2005

Rapid Communications in Mass Spectrometry

Noncovalent RNA-peptide complexes detected by matrix-assisted laser desorption/ionization mass spectrometry.
Thiede, B. and von Janta-Lipinski, M.
Rapid Communications in Mass Spectrometry 12 : 1889-1894. 1 January 1998

Research in Virology

Human conglutinin-like protein inhibits infection by the human immunodeficiency virus-1 in vitro.
Ushijima, H., Schroeder, H.C., Poznanovic, S., Matthes, E. and Mueller, W.E.G.
Research in Virology 143 : 97-99. 1 January 1992

Sensorik

Nachweis der Telomeraseaktivitaet in Zellkulturen mittels eines faseroptischen Sensors.
Schmidt, P.M., Matthes, E., Scheller, F.W. and Bier, F.F.
Sensorik : 51-55. 2001

Tetrahedron

Stereocontrolled synthesis of the four stereoisomeric diphosphorylphosphonates of carbocyclic 2',3'-dideoxy-2', 3'- didehydro-5'-noradenosine.
Dyatkina, N.B., Theil, F. and von Janta-Lipinski, M.
Tetrahedron 51 : 761-772. 1 January 1995

Tetrahedron Letters

Synthesis of the four possible stereoisomeric 5'-nor carbocyclic nucleotides from one common enantiomeritally pure starting material.
Dyatkina, N., Costiselli, B., Theil, F. and von Janta-Lipinski, M.
Tetrahedron Letters 35 : 1961-1964. 1 January 1994

Virus Research

Avoral restores the altered prostaglandin and leukotriene metabolism in monocytes infected with human immunodeficiency virus type 1.
Schroeder, H.C., Begin, M.E., Kloecking, R., Matthes, E., Sarma, A.S., Gasic, M.J. and Mueller, W.E.G.
Virus Research 21 : 213-223. 1 January 1991