Browse by Research Team

2012

Strong antiviral activity of the new l-hydroxycytidine derivative, l-Hyd4FC, in HBV-infected human chimeric uPA/SCID mice.
Volz, T., Luetgehetmann, M., Allweiss, L., Warlich, M., Bierwolf, J., Pollok, J.M., Petersen, J., Matthes, E. and Dandri, M.
Antiviral Therapy 17 (4): 623-631. 27 February 2012

2010

Cellular pharmacology of the anti-hepatitis B virus agent beta-L-2',3'-didehydro-2',3'-dideoxy-N4-hydroxycytidine: relevance for activation in HepG2 cells.
Matthes, E. and Buenger, H.
Antimicrobial Agents and Chemotherapy 54 (1): 341-345. 16 January 2010

2007

Strong and selective inhibitors of HBV-replication between novel N4-hydroxy-and 5-methyl-beta-L-deoxycytidine analogues.
Matthes, E., Funk, A., Krahn, I., Gaertner, K., von Janta-Lipinski, M., Lin, L., Will, H. and Sirma, H.
Antimicrobial Agents and Chemotherapy 51 (7): 2523-2530. July 2007

2006

Beta-L-N4-Hydroxycytosin-Desoxynucleoside und ihre Verwendung als pharmazeutische Mittel zur Prophylaxe oder Therapie von viralen Erkrankungen [Beta-L-N4-hydroxycytosine deoxynucleosides and their use as pharmaceutical agents in the prophylaxis or therapy of viral diseases].
Matthes, E., Janta-Lipinski, M., Will, H., Sirma, H. and Funk, A.
DE102004051804A1 ; WO06045616. 27 April 2006

2005

Potent inhibitory activity of chimeric oligonucleotides targeting two different sites of human telomerase.
Matthes, E., Lehmann, C., Stulich, M., Wu, Y., Dimitrova, L., Uhlmann, E. and Janta-Lipinski, M.V.
Oligonucleotides 15 (4): 255-268. December 2005

Beta-L-nucleosides and use thereof as pharmaceutical agents for the treatment of viral diseases [Beta-L-Nucleoside und ihre Verwendung als pharmazeutische Mittel zur Behandlung viraler Erkrankungen].
Matthes, E., Janta-Lipinski, M., Will, H., Sirma, H. and Li, L.
EP1668023 ; WO0526186. 24 March 2005

An improved method for determining telomere length and its use in assessing age in blood and saliva.
Lahnert, P.
Gerontology 51 (5): 352-356. 1 January 2005

2003

Antimetaboliten.
Matthes, E. and Langen, P.
In: Grundlagen der Molekularen Medizin. Molekulare Medizin . Springer, Berlin [u.a.], 631-679. ISBN 3-540-43207-8 1 January 2003

2002

Detection of activity of telomerase in tumor cells using fiber optical biosensors.
Schmidt, P.M., Lehmann, C., Matthes, E. and Bier, F.F.
Biosensors and Bioelectronics 17 (11-12): 1081-1087. December 2002

Real-time determination of telomerase activity in cell extracts using an optical biosensor.
Schmidt, P.M., Matthes, E., Scheller, F.W., Bienert, M., Lehmann, C., Ehrlich, A. and Bier, F.F.
Biological Chemistry 383 (10): 1659-1666. October 2002

Verfahren zur Herstellung von C-Nukleosiden und C-Nukleosid-Analoga, neue C-Nukleoside und C-Nukleosid-Analoga sowie deren Verwendung.
Baerwolff, D.
DE4320570C2. 11 July 2002

2001

Up-regulation of telomerase activity in Herpesvirus saimiri immortalized human T-lymphocytes.
Harnack, U., Lehmann, C., Matthes, E. and Pecher, G.
Anticancer Research 21 : 3969-3972. 1 January 2001

Nachweis der Telomeraseaktivitaet in Zellkulturen mittels eines faseroptischen Sensors.
Schmidt, P.M., Matthes, E., Scheller, F.W. and Bier, F.F.
Sensorik : 51-55. 2001

2000

Inhibition of adenovirus DNA polymerase by modified nucleoside triphosphate analogs correlate with their antiviral effects on cellular level.
Mentel, R., Kurek, S., Wegner, U., von Janta-Lipinski, M., Gurtler, L. and Matthes, E.
Medical Microbiology and Immunology 189 (2): 91-95. 1 November 2000

1999

Telomerase protein rather than its RNA is the target of phosphorothioate-modified oligonucleotides.
Matthes, E. and Lehmann, C.
Nucleic Acids Research 27 (4): 1152-1158. 15 February 1999

Protein and RNA of human telomerase as targets for modified oligonucleotides.
von Janta-Lipinski, M., Gaertner, K., Lehmann, C., Scheer, H., Schildt, J. and Matthes, E.
Nucleosides Nucleotides & Nucleic Acids 18 : 1719-1720. 1 January 1999

Reasons and limits of substrate activity of modified L-dNTP in DNA biosynthesis.
Krayevsky, A.A., Dyatkina, N.B., Semizarov, D.G., Victorova, L.S., Shirokova, E.A., Theil, F., von Janta-Lipinski, M., Gosselin, G. and Imbach, J.L.
Nucleosides Nucleotides & Nucleic Acids 18 : 863-864. 1 January 1999

1998

Chimaere Oligonucleotide und ihre Verwendung [Chimeric oligonucleotides and the use thereof].
Matthes, E. and Janta-Lipinski, M.
DE19720151A1 ; EP0980379A2 ; EP0980379B1 ; WO9850397A2 ; WO9850397A3. 5 November 1998

Verwendung von Dinucleotiden zur Prophylaxe und/oder Behandlung von durch Human Immunodeficiency Viren oder Hepatitis-B Viren verursachten Infektionen.
Matthes, E. and Janta-Lipinski, M.
DE19640054A1. 2 April 1998

Antisense oligodesoxynucleotide strategies in renal and cardiovascular disease.
Haller, H., Maasch, C., Dragun, D., Wellner, M., von Janta-Lipinski, M. and Luft, F.C.
Kidney International 53 : 1550-1558. 1 January 1998

Chemo-enzymatic synthesis of a new type of enantiomerically pure carbocyclic nucleoside analogues with strong inhibitory effects on terminal deoxynucleotidyl transferase.
Theil, F., Ballschuh, S., Flatau, S., von Janta-Lipinski, M. and Matthes, E.
Bioorganic and Medicinal Chemistry 6 : 701-706. 1 January 1998

Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'- deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta and epsilon nor HIV-1 reverse transcriptase.
von Janta-Lipinski, M., Costisella, B., Ochs, H., Huebscher, U., Hafkemeyer, P. and Matthes, E.
Journal of Medicinal Chemistry 41 : 2040-2046. 1 January 1998

Noncovalent RNA-peptide complexes detected by matrix-assisted laser desorption/ionization mass spectrometry.
Thiede, B. and von Janta-Lipinski, M.
Rapid Communications in Mass Spectrometry 12 : 1889-1894. 1 January 1998

1997

Antimetaboliten.
Matthes, E. and Langen, P.
In: Molekular- und Zellbiologische Grundlagen. Handbuch der Molekularen Medizin ; 1 . Springer, Berlin [u.a.], 266-301. 1 January 1997

Inhibitory activity of 3'-fluoro 2' deoxythymidine and related nucleoside analogues against adenoviruses in vitro.
Mentel, R., Kinder, M., Wegner, U., von Janta-Lipinski, M. and Matthes, E.
Antiviral Research 34 : 113-119. 1 January 1997

1996

Neue beta-L-Nucleoside und ihre Verwendung.
Matthes, E. and von Janta-Lipinski, M.
DE19518216A1. 11 April 1996

2',3'-dideoxynucleoside pyrimidine compounds and carbocyclic analogs.
Matthes, E., Janta-Lipinski, M., Scholz, D., Gaertner, K., Schildt, J., Lehmann, C., Langen, P. and Rosenthal, H.A.
US5,496,935. 5 March 1996

Chemoenzymatic synthesis of carbocyclic nucleoside analogues with bicyclo[3.1.0]hexyl residues.
Theil, F., Ballschuh, S., von Janta-Lipinski, M. and Johnson, R.A.
Journal of the Chemical Society. Perkin Transactions 1 1 : 255-258. 1 January 1996

Fluorescent focus reduction assay for the screening of antiadenoviral agents.
Mentel, R., Matthes, E., von Janta-Lipinski, M. and Wegner, U.
Journal of Virological Methods 59 : 99-104. 1 January 1996

Inhibition of duck hepatitis B virus replication by 2',3'-Dideoxy-3'-Fluoroguanosine in vitro and in vivo.
Hafkemeyer, P., Keppler-Hafkemeyer, A., al Haya, M.A., von Janta-Lipinski, M., Matthes, E., Lehmann, C., Offensperger, W.B., Offensperger, S., Gerok, W. and Blum, H.E.
Antimicrobial Agents and Chemotherapy 40 : 792-794. 1 January 1996

Selective endocytosis of fluorothymidine and azidothymidine coupled to LDL into HIV infected mononuclear cells.
Mankertz, J., Matthes, E., Rokos, K., von Baeyer, H., Pauli, G. and Riedel, E.
Biochimica et Biophysica Acta 1317 : 233-237. 1 January 1996

Side-chain derivatives of biologically active nucleosides. Part 2: Synthesis and anti-HIV activity of 5'-C-methyl derivatives of 3'-fluoro-3'-deoxythymidine.
Hiebl, J., Zbiral, E., von Janta-Lipinski, M., Balzarini, J. and De Clercq, E.
Antiviral Chemistry and Chemotherapy 7 : 173-177. 1 January 1996

1995

Potential suitability of Na+/K+ -transporting ATPase in pre-screens for anti-cancer agents.
Repke, K.R.H., Schoen, R., Megges, R., Weiland, J., Nissen, E. and Matthes, E.
Anti-Cancer Drug Design 10 : 177-187. 1 January 1995

Stereocontrolled synthesis of the four stereoisomeric diphosphorylphosphonates of carbocyclic 2',3'-dideoxy-2', 3'- didehydro-5'-noradenosine.
Dyatkina, N.B., Theil, F. and von Janta-Lipinski, M.
Tetrahedron 51 : 761-772. 1 January 1995

Synthesis of four stereoisomers of carbocyclic 5'-NOR D4A and evaluation of their triphosphates as substrates for DNA polymerases.
Dyatkina, N., Semizarov, D., Victorova, L., Krayevsky, A., Theil, F. and von Janta-Lipinski, M.
Nucleosides Nucleotides & Nucleic Acids 14 : 723-726. 1 January 1995

1994

Selectivity of DNA polymerases toward alpha and beta nucleotide substrate of D and L series.
Semizarov, D.G., Victorova, L.S., Dyatkina, N.B., von Janta-Lipinski, M. and Krayevsky, A.A.
FEBS Letters 354 : 187-190. 1 January 1994

Synthesis of the four possible stereoisomeric 5'-nor carbocyclic nucleotides from one common enantiomeritally pure starting material.
Dyatkina, N., Costiselli, B., Theil, F. and von Janta-Lipinski, M.
Tetrahedron Letters 35 : 1961-1964. 1 January 1994

Tamoxifen is a Na+-antagonistic inhibitor of Na+K+-transporting ATPase from tumour and normal cells.
Repke, K.R.H. and Matthes, E.
Journal of Enzyme Inhibition 8 : 207-212. 1 January 1994

Vergleichende Untersuchungen zu den Wirkungs- und Toxizitaetsunterschieden der HIV-RT Hemmstoffe 3`-Fluor-5-chlordesoxyridin (FCU) und 3`-Fluorthymidin.
Matthes, E. and Grade, G.
AIDS-Forschung 9 : 584. 1 January 1994

1993

Antivirale Nucleosidanaloga, ihre Herstellung und ihre pharmazeutische Anwendung.
Matthes, E. and von Janta-Lipinski, M.
DE4207363A1. 9 September 1993

Verwendung von Pyrimidin- und Purinnucleosiden zur Phrophylaxe und/oder Behandlung von durch Adenoviren verursachten Infekten.
Matthes, E., von Janta-Lipinski, M. and Mentel, R.
DE4121001C1. 6 May 1993

Novel lectin-based enzyme-linked immunoassay for the quantitation of envelope glycoprotein 120 of human immunodeficiency virus.
Mueller, W.E.G., Matthes, E., Bachmann, M., Kljajic, Z., Gasic, M.J. and Forrest, J.M.S.
In: Lectins: Biology, Biochemistry, Clinical Biochemistry ; Vol. 8. TESTOP-Verl., Kopenhagen, 341-347. 1 January 1993

Synergistic anti-human immunodeficiency viral (HIV-1) effect of the immunomodulator ampligen (mismatched double- stranded RNA) with inhibitors of reverse transcriptase and HIV-1 regulatory proteins.
Ushijima, H., Tsiapalis, C.M., Daum, T., Schroeder, H.C., Matthes, E., Engels, J.W., Mag, M., Muth, J. and Mueller, W.E.G.
Antiviral Chemistry and Chemotherapy 4 : 315-321. 1 January 1993

1992

ELISA for the quantification of HIV-1 env glycoprotein 120: some practical applications.
Ushijima, H., Mangel, A., Forrest, J.M.S., Kunisada, T., Matthes, E. and Mueller, W.E.G.
AIDS-Forschung 7 : 185-189. 1 January 1992

Human conglutinin-like protein inhibits infection by the human immunodeficiency virus-1 in vitro.
Ushijima, H., Schroeder, H.C., Poznanovic, S., Matthes, E. and Mueller, W.E.G.
Research in Virology 143 : 97-99. 1 January 1992

Inhibition of hepatitis B virus production by modified 2',3'-dideoxy-thymidine and 2',3'-dideoxy-5-methylcytidine derivatives. In vitro and in vivo studies.
Matthes, E., von Janta-Lipinski, M., Will, M., Schroeder, C., Merz, H., Steffen, R. and Mueller, W.E.G.
Biochemical Pharmacology 43 : 1571-1577. 1 January 1992

Inhibition of human immunodeficiency virus-1 infection by human conglutinin-like protein: in vitro studies.
Ushijima, H., Schroeder, H.C., Poznanovic, S., Gasic, M.J., Matthes, E. and Mueller, W.E.G.
Japanese Journal of Cancer Research 83 : 458-464. 1 January 1992

Modifizierte 2',3'- Didesoxynucleoside als potentielle Hemmstoffe der Replikation des Human Immunodeficiency Virus und des Hepatitis B Virus (Habilitationsschrift, Humboldt-Universitaet zu Berlin, Fachbereich, Medizin, 1992).
Matthes, E.
UNSPECIFIED thesis, UNSPECIFIED. 1 January 1992

1991

Avoral restores the altered prostaglandin and leukotriene metabolism in monocytes infected with human immunodeficiency virus type 1.
Schroeder, H.C., Begin, M.E., Kloecking, R., Matthes, E., Sarma, A.S., Gasic, M.J. and Mueller, W.E.G.
Virus Research 21 : 213-223. 1 January 1991

Biochemical and genetical analysis of AZT-resistant HIV-mutants.
Biesert, L., Zimmermann, F., Schroeder, B., Matthes, E., Suhartono, H., Dietrich, U. and Rubsamen-Waigmann, H.
Behring Institute Mitteilungen 89 : 74-80. 1 January 1991

Comparative inhibition of hepatitis B virus and DNA polymerase and cellular DNA polymerases by triphosphates of sugar-modified 5-methyldeoxycytidines and other nucleoside analogs.
Matthes, E., Reimer, K., von Janta-Lipinski, M., Meisel, H. and Lehmann, C.
Antimicrobial Agents and Chemotherapy 36 : 1254-1257. 1 January 1991

Human immunodeficiency virus: novel enzyme-linked immunoassays for quantitation of envelope glycoprotein 120.
Weiler, B.E., Schaecke, H., Bachmann, M., Bridigo, L., Gilbert, M., Mills, J., Matthes, E., Forrest, J.M.S. and Mueller, W.E.G.
Journal of Virological Methods 32 : 287-301. 1 January 1991

Inhibition of hepatitis B virus DNA polymerase by thymidine triphosphate analogues in vitro.
Reimer, K., Matthes, E., von Janta-Lipinski, M. and Meisel, H.
Antiviral Chemistry & Chemotherapy 1 : 249-253. 1 January 1991

Narcissus and Gerardia lectins: tools for the development of a vaccine against AIDS and a new ELISA to quantitativ HIV-gp 120.
Mueller, W.E.G., Forrest, J.M.S., Chang, S.H., Weiler, B.E., Schaecke, H., Matthes, E. and Bachmann, M.
In: Lectins and Cancer. Springer, Heidelberg [u.a.], 27-40. 1 January 1991

Synthesis and anti-HIV activity of modified 2',3'-dideoxy- 3'-fluoro pyrimidine nucleosides.
von Janta-Lipinski, M., Gaertner, K., Schildt, E., Matthes, E., Scholz, D. and Langen, P.
Nucleosides Nucleotides & Nucleic Acids 10 : 651-652. 1 January 1991