Browse by Research Team

2024

TENM4 is an essential transduction component for touch and pain.
Khallaf, M.A., Huang, A.T.L., Dalmasso, L., Chakrabarti, S., Groeneveld, R., Sierra, Y.A.B., Garcia-Contreras, J.A., Schutz, A., Bégay, V., Hedtrich, S., Zhong, W., Popp, O., Mertins, P. and Lewin, G.R.
bioRxiv : 2024.10.10.617546. 12 October 2024

Piezo2 voltage-block regulates mechanical pain sensitivity.
Sánchez-Carranza, O., Chakrabarti, S., Kühnemund, J., Schwaller, F., Bégay, V., García-Contreras, J.A., Wang, Lin and Lewin, G.R.
Brain 147 (10): 3487-3500. October 2024

A novel developmental critical period of orexinergic signaling in the primary visual thalamus.
Sanetra, A.M., Jeczmien-Lazur, J.S., Pradel, K., Klich, J.D., Palus-Chramiec, K., Janik, M.E., Bajkacz, S., Izowit, G., Nathan, C., Piggins, H.D., Delogu, A., Belle, M.D.C., Lewandowski, M.H. and Chrobok, L.
iScience 27 (7): 110352. 19 July 2024

Mechanosensitive PIEZO2 channels shape coronary artery development.
Pampols-Perez, M., Fürst, C., Sánchez-Carranza, O., Cano, E., Raimundo, S., Lindberg, E.L., Taube, M., Heuser, A., Sporbert, A., Hübner, N., Gerhardt, H., Lewin, G.R. and Hammes, A.
bioRxiv : 2024.07.08.602502. 11 July 2024

Touch sensation requires the mechanically gated ion channel ELKIN1.
Chakrabarti, S., Klich, J.D., Khallaf, M.A., Hulme, A.J., Sánchez-Carranza, O., Baran, Z.M., Rossi, A., Huang, A.T.L., Pohl, T., Fleischer, R., Fürst, C., Hammes, A., Bégay, V., Hörnberg, H., Finol-Urdaneta, R.K., Poole, K., Dottori, M. and Lewin, G.
Science 383 (6686): 992-998. 1 March 2024

Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2.
Desiderio, S., Schwaller, F., Tartour, K., Padmanabhan, K., Lewin, G.R., Carroll, P. and Marmigere, F.
eLife 12 : RP89287. 22 February 2024

Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception.
Ojeda-Alonso, J., Calvo-Enrique, L., Paricio-Montesinos, R., Kumar, R., Zhang, M.D., Poulet, J.F.A., Ernfors, P. and Lewin, G.R.
Nature Communications 15 (1): 898. 6 February 2024

2023

Proglucagon signalling in the rat dorsomedial hypothalamus - physiology and high-fat diet-mediated alterations.
Sanetra, A M., Palus-Chramiec, K., Chrobok, L., Jeczmien-Lazur, J.S., Klich, J.D. and Lewandowski, M.H.
Molecular and Cellular Neuroscience 126 : 103873. September 2023

Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
Lowenstein, E.D., Ruffault, P.L., Misios, A., Osman, K.L., Li, H., Greenberg, R.S., Thompson, R., Song, K., Dietrich, S., Li, X., Vladimirov, N., Woehler, A., Brunet, J.F., Zampieri, N., Kühn, R., Liberles, S.D., Jia, S., Lewin, G.R., Rajewsky, N., Lever, T.E. and Birchmeier, C.
Neuron 111 (14): 2184-2200.e7. 19 July 2023

Role of TMEM100 in mechanically insensitive nociceptor un-silencing.
Nees, T.A., Wang, N., Adamek, P., Zeitzschel, N., Verkest, C., La Porta, C., Schaefer, I., Virnich, J., Balkaya, S., Prato, V., Morelli, C., Begay, V., Lee, Y.J., Tappe-Theodor, A., Lewin, G.R., Heppenstall, P.A., Taberner, F.J. and Lechner, S.G.
Nature Communications 14 (1): 1899. 5 April 2023

The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation.
Meier, M., Gupta, M., Akgül, S., McDougall, M., Imhof, T., Nikodemus, D., Reuten, R., Moya-Torres, A., To, V., Ferens, F., Heide, F., Padilla-Meier, G.P., Kukura, P., Huang, W., Gerisch, B., Mörgelin, M., Poole, K., Antebi, A., Koch, M. and Stetefeld, J.
Nature Communications 14 (1): 1226. 3 March 2023

2022

Lack of evidence for participation of TMEM150C in sensory mechanotransduction.
Ojeda-Alonso, J., Bégay, V., Garcia-Contreras, J.A., Campos-Pérez, A.F., Purfürst, B. and Lewin, G.R.
Journal of General Physiology 154 (12): e202213098. 5 December 2022

High-fat-diet-evoked disruption of the rat dorsomedial hypothalamic clock can be prevented by restricted nighttime feeding.
Sanetra, A.M., Acevedo-Ochoa, E., Chrobok, L., Jeczmien-Lazur, J.S., Gawron, E., Klich, J.D., Pradel, K. and Lewandowski, M.H.
Nutrients 14 (23): 5034. 26 November 2022

The molecular mechanism and physiological role of silent nociceptor activation.
Nees, T.A., Wang, N., Adamek, P., Verkest, C., Schaefer, I., Virnich, J., Balkaya, S., Prato, V., Morelli, C., Zeitzschel, N., Begay, V., Lee, Y.J., Lewin, G.R., Heppenstall, P.A., Taberner, F.J. and Lechner, S.G.
bioRxiv : 2022.04.07.486730. 19 October 2022

Immune competence and spleen size scale with colony status in the naked mole-rat.
Bégay, V., Cirovic, B., Barker, A.J., Klopffleisch, R., Hart, D.W., Bennett, N.C. and Lewin, G.R.
Open Biology 12 (4): 210292. 6 April 2022

In memoriam: Stephen B. McMahon, PhD, FMedSci December 21, 1954 to October 9, 2021.
Bennett, D.L.H., Bradbury, E.J., Lewin, G.R. and Rice, A.S.C.
Pain 163 (3): 403-405. March 2022

SPFH protein cage - one ring to rule them all.
Daumke, O. and Lewin, G.R.
Cell Research 32 (2): 117-118. February 2022

The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole-rat biology.
Buffenstein, R., Amoroso, V., Andziak, B., Avdieiev, S., Azpurua, J., Barker, A.J., Bennett, N.C., Brieño-Enríquez, M.A., Bronner, G.N., Coen, C., Delaney, M.A., Dengler-Crish, C.M., Edrey, Y.H., Faulkes, C.G., Frankel, D., Friedlander, G., Gibney, P.A., Gorbunova, V., Hine, C., Holmes, M.M., Jarvis, J.U.M., Kawamura, Y., Kutsukake, N., Kenyon, C., Khaled, W.T., Kikusui, T., Kissil, J., Lagestee, S., Larson, J., Lauer, A., Lavrenchenko, L.A., Lee, A., Levitt, J.B., Lewin, G.R., Lewis Hardell, K.N., Lin, T.D., Mason, M.J., McCloskey, D., McMahon, M., Miura, K., Mogi, K., Narayan, V., O'Connor, T.P., Okanoya, K., O'Riain, M.J., Park, T.J., Place, N.J., Podshivalova, K., Pamenter, M.E., Pyott, S.J., Reznick, J., Ruby, J.G., Salmon, A.B., Santos-Sacchi, J., Sarko, D.K., Seluanov, A., Shepard, A., Smith, M., Storey, K.B., Tian, X., Vice, E.N., Viltard, M., Watarai, Ak., Wywial, E., Yamakawa, M., Zemlemerova, E.D., Zions, M. and Smith, E.S.J.
Biological Reviews 97 (1): 115-140. February 2022

2021

Functional characterization of ovine dorsal root ganglion neurons reveal peripheral sensitization after osteochondral defect.
Chakrabarti, S., Ai, M., Wong, K., Newell, K., Henson, F.M.D. and Smith, E.S.J.
eNeuro 8 (5): ENEURO.0237-21.2021. September 2021

Identification of disease-relevant modulators of the SHH pathway in the developing brain.
Mecklenburg, N., Kowalczyk, I., Witte, F., Görne, J., Laier, A., Mamo, T.M., Gonschior, H., Lehmann, M., Richter, M., Sporbert, A., Purfürst, B., Hübner, N. and Hammes, A.
Development 148 (17): dev199307. September 2021

A sweet story of metabolic innovation in the naked mole-rat.
Reznick, J., Park, T.J. and Lewin, G.R.
Advances in Experimental Medicine and Biology 1319 (1319): 271-286. 24 August 2021

African naked mole-rats demonstrate extreme tolerance to hypoxia and hypercapnia.
Park, T.J., Smith, E.S.J., Reznick, J., Bennett, N.C., Applegate, D.T., Larson, J. and Lewin, G.R.
Advances in Experimental Medicine and Biology 1319 (1319): 255-269. 24 August 2021

Hearing and vocalizations in the naked mole-rat.
Barker, A.J., Koch, U., Lewin, G.R. and Pyott, S.J.
Advances in Experimental Medicine and Biology 1319 (1319): 157-195. 24 August 2021

The somatosensory world of the African naked mole-rat.
Lewin, G.R., Smith, E.S.J., Reznick, J., Debus, K.Y., Barker, A.J. and Park, T.J.
Advances in Experimental Medicine and Biology 1319 (1319): 197-220. 24 August 2021

Mitochondrial bioenergetics and neurodegeneration: a paso doble.
Rossi, A. and Pizzo, P.
Neural Regeneration Research 16 (4): 686-687. April 2021

A role for STOML3 in olfactory sensory transduction.
Agostinelli, E., Gonzalez-Velandia, K.Y., Hernandez-Clavijo, A., Maurya, D.K., Xerxa, E., Lewin, G.R., Dibattista, M., Menini, A. and Pifferi, S.
eNeuro 8 (2): ENEURO.0565-20.2021. 26 March 2021

Cultural transmission of vocal dialect in the naked mole-rat.
Barker, A.J., Veviurko, G., Bennett, N.C., Hart, D.W., Mograby, L. and Lewin, G.R.
Science 371 (6528): 503-507. 29 January 2021

USH2A is a Meissner's corpuscle protein necessary for normal vibration sensing in mice and humans.
Schwaller, F., Bégay, V., García-García, G., Taberner, F.J., Moshourab, R., McDonald, B., Docter, T., Kühnemund, J., Ojeda-Alonso, J., Paricio-Montesinos, R., Lechner, S.G., Poulet, J.F.A., Millan, J.M. and Lewin, G.R.
Nature Neuroscience 24 (1): 74-81. January 2021

2020

The mechanotransduction protein STOML3 is required for functional plasticity following peripheral nerve regeneration.
Haseleu, J., Walcher, J. and Lewin, G.R.
bioRxiv : 2020.11.10.367748. 10 November 2020

SUMOylation of enzymes and ion channels in sensory neurons protects against metabolic dysfunction, neuropathy, and sensory loss in diabetes.
Agarwal, N., Taberner, F.J., Rangel Rojas, D., Moroni, M., Omberbasic, D., Njoo, C., Andrieux, A., Gupta, P., Bali, K.K., Herpel, E., Faghihi, F., Fleming, T., Dejean, A., Lechner, S.G., Nawroth, P.P., Lewin, G.R. and Kuner, R.
Neuron 107 (6): 1141-1159. 23 September 2020

William D. Willis, Jr, MD, PhD Memorial Lecture: the evolutionary history of nerve growth factor and nociception.
Lewin, G.R.
Pain 161 (9 Suppl 1): S36-S47. September 2020

Peripheral mechanisms of arthritic pain: a proposal to leverage large animals for in vitro studies.
Chakrabarti, S., Ai, M., Henson, F.M.D. and Smith, E.S.J.
Neurobiology of Pain 8 : 100051. 28 August 2020

The sensory coding of warm perception.
Paricio-Montesinos, R., Schwaller, F., Udhayachandran, A., Rau, F., Walcher, J., Evangelista, R., Vriens, J., Voets, T., Poulet, J.F.A. and Lewin, G.R.
Neuron 106 (5): 830-841. 3 June 2020

Collagen organization within the cartilage of TRPV4(-/-) mice studied with two-photon microscopy and polarized second harmonic generation.
Servin-Vences, M.R., Poole, K., Sporbert, A., Lewin, G.R. and Margineanu, A.
Cytometry Part A 97 (5): 504-514. May 2020

Independent evolution of pain insensitivity in African mole-rats: origins and mechanisms.
Smith, E.S.J., Park, T.J. and Lewin, G.R.
Journal of Comparative Physiology A 206 (3): 313-325. May 2020

TMEM87a/Elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration.
Patkunarajah, A., Stear, J.H., Moroni, M., Schroeter, L., Blaszkiewicz, J., Tearle, J.L.E., Cox, C.D., Fuerst, C., Sánchez-Carranza, O., Ocaña Fernández, M.D.A., Fleischer, R., Eravci, M., Weise, C., Martinac, B., Biro, M., Lewin, G.R. and Poole, K.
eLife 9 : e53308. 31 March 2020

2019

Rapid molecular evolution of pain insensitivity in multiple African rodents.
Eigenbrod, O., Debus, K.Y., Reznick, J., Bennett, N.C., Sánchez-Carranza, O., Omerbašić, D., Hart, D.W., Barker, A.J., Zhong, W., Lutermann, H., Katandukila, J.V., Mgode, G., Park, T.J. and Lewin, G.R.
Science 364 (6443): 852-859. 31 May 2019

2018

Specialized mechanoreceptor systems in rodent glabrous skin.
Walcher, J., Ojeda-Alonso, J., Haseleu, J., Oosthuizen, M.K., Rowe, A.H., Bennett, N.C. and Lewin, G.R.
Journal of Physiology 596 (20): 4995-5016. 15 October 2018

The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice.
Murthy, S.E., Loud, M.C., Daou, I., Marshall, K.L., Schwaller, F., Kühnemund, J., Francisco, A.G., Keenan, W.T., Dubin, A.E., Lewin, G.R. and Patapoutian, A.
Science Translational Medicine 10 (462): eaat9897. 10 October 2018

The neural circuits of thermal perception.
Bokiniec, P., Zampieri, N., Lewin, G.R. and Poulet, J.F.A.
Current Opinion in Neurobiology 52 : 98-106. October 2018

The C/EBPβ LIP isoform rescues loss of C/EBPβ function in the mouse.
Bégay, V., Baumeier, C., Zimmermann, K., Heuser, A. and Leutz, A.
Scientific Reports 8 (1): 8417. 30 May 2018

Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells.
Kim, M., Wende, H., Walcher, J., Kühnemund, J., Cheret, C., Kempa, S., McShane, E., Selbach, M., Lewin, G.R. and Birchmeier, C.
Genes & Development 32 (9-10): 645-657. 10 May 2018

Mechanoelectrical transduction in chondrocytes.
Servin-Vences, M.R., Richardson, J., Lewin, G.R. and Poole, K.
Clinical and Experimental Pharmacology & Physiology 45 (5): 481-488. May 2018

Voltage gating of mechanosensitive PIEZO channels.
Moroni, M., Servin-Vences, M.R., Fleischer, R., Sánchez-Carranza, O. and Lewin, G.R.
Nature Communications 9 (1): 1096. 15 March 2018

Immune or genetic-mediated disruption of CASPR2 causes pain hypersensitivity due to enhanced primary afferent excitability.
Dawes, J.M., Weir, G.A., Middleton, S.J., Patel, R., Chisholm, K.I., Pettingill, P., Peck, L.J., Sheridan, J., Shakir, A., Jacobson, L., Gutierrez-Mecinas, M., Galino, J., Walcher, J., Kühnemund, J., Kuehn, H., Sanna, M.D., Lang, B., Clark, A.J., Themistocleous, A.C., Iwagaki, N., West, S.J., Werynska, K., Carroll, L., Trendafilova, T., Menassa, D.A., Giannoccaro, M.P., Coutinho, E., Cervellini, I., Tewari, D., Buckley, C., Leite, M.I., Wildner, H., Zeilhofer, H.U., Peles, E., Todd, A.J., McMahon, S.B., Dickenson, A.H., Lewin, G.R., Vincent, A. and Bennett, D.L.
Neuron 97 (4): 806-822. 21 February 2018

The absence of sensory axon bifurcation affects nociception and termination fields of afferents in the spinal cord.
Tröster, P., Haseleu, J., Petersen, J., Drees, O., Schmidtko, A., Schwaller, F., Lewin, G.R., Ter-Avetisyan, G., Winter, Y., Peters, S., Feil, S., Feil, R., Rathjen, F.G. and Schmidt, H.
Frontiers in Molecular Neuroscience 11 : 19. 8 February 2018

2017

Effects of feeding time on daily rhythms of neuropeptide and clock gene expression in the rat hypothalamus.
Wang, D., Opperhuizen, A.L., Reznick, J., Turner, N., Su, Y., Cooney, G.J. and Kalsbeek, A.
Brain Research 1671 : 93-101. 15 September 2017

Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.
Rathjen, T., Yan, X., Kononenko, N.L., Ku, M.C., Song, K., Ferrarese, L., Tarallo, V., Puchkov, D., Kochlamazashvili, G., Brachs, S., Varela, L., Szigeti-Buck, K., Yi, C.X., Schriever, S.C., Tattikota, S.G., Carlo, A.S., Moroni, M., Siemens, J., Heuser, A., van der Weyden, L., Birkenfeld, A.L., Niendorf, T., Poulet, J.F.A., Horvath, T.L., Tschöp, M.H., Heinig, M., Trajkovski, M., Haucke, V. and Poy, M.N.
Nature Neuroscience 20 (8): 1096-1103. August 2017

Congenital deafness is associated with specific somatosensory deficits in adolescents.
Moshourab, R., Bégay, V., Wetzel, C., Walcher, J., Middleton, S., Gross, M. and Lewin, G.R.
Scientific Reports 7 (1): 4251. 26 June 2017

The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord.
Schwaller, F., Kanellopoulos, A.H. and Fitzgerald, M.
Scientific Reports 7 (1): 2215. 22 May 2017

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.
Park, T.J., Reznick, J., Peterson, B.L., Blass, G., Omerbašić, D., Bennett, N.C., Kuich, P.H.J.L., Zasada, C., Browe, B.M., Hamann, W., Applegate, D.T., Radke, M.H., Kosten, T., Lutermann, H., Gavaghan, V., Eigenbrod, O., Bégay, V., Amoroso, V. G., Govind, V., Minshall, R.D., Smith, E.S.J., Larson, J., Gotthardt, M., Kempa, S. and Lewin, G.R.
Science 356 (6335): 307-311. 21 April 2017

Genetic tracing of Ca(V)3.2 T-type calcium channel expression in the peripheral nervous system.
Bernal Sierra, Y.A., Haseleu, J., Kozlenkov, A., Bégay, V. and Lewin, G.R.
Frontiers in Molecular Neuroscience 10 (70): 70. 15 March 2017

C/EBP-induced transdifferentiation reveals granulocyte-macrophage precursor-like plasticity of B cells.
Cirovic, B., Schönheit, J., Kowenz-Leutz, E., Ivanovska, J., Klement, C., Pronina, N., Bégay, V. and Leutz, A.
Stem Cell Reports 14 (8): 346-359. 14 February 2017

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.
Wetzel, C., Pifferi, S., Picci, C., Gök, C., Hoffmann, D., Bali, K.K., Lampe, A., Lapatsina, L., Fleischer, R., Smith, E.S.J., Bégay, V., Moroni, M., Estebanez, L., Kühnemund, J., Walcher, J., Specker, E., Neuenschwander, M., von Kries, J.P., Haucke, V., Kuner, R., Poulet, J.F.A., Schmoranzer, J., Poole, K. and Lewin, G.R.
Nature Neuroscience 20 (2): 209-218. February 2017

Lipidome determinants of maximal lifespan in mammals.
Bozek, K., Khrameeva, E.E., Reznick, J., Omerbašić, D., Bennett, N.C., Lewin, G.R., Azpurua, J., Gorbunova, V., Seluanov, A., Regnard, P., Wanert, F., Marchal, J., Pifferi, F., Aujard, F., Liu, Z., Shi, P., Pääbo, S., Schroeder, F., Willmitzer, L., Giavalisco, P. and Khaitovich, P.
Scientific Reports 7 : 5. 31 January 2017

Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes.
Servin-Vences, M.R., Moroni, M., Lewin, G.R. and Poole, K.
eLife 6 : e21074. 30 January 2017

2016

Fxyd2 regulates Aδ- and C-fiber mechanosensitivity and is required for the maintenance of neuropathic pain.
Ventéo, S., Laffray, S., Wetzel, C., Rivat, C., Scamps, F., Méchaly, I., Bauchet, L., Raoul, C., Bourinet, E., Lewin, G.R., Carroll, P. and Pattyn, A.
Scientific Reports 6 : 36407. 2 November 2016

Hypofunctional TrkA accounts for the absence of pain sensitization in the African naked mole-rat.
Omerbašić, D., Smith, E.S.J., Moroni, M., Homfeld, J., Eigenbrod, O., Bennett, N.C., Reznick, J., Faulkes, C.G., Selbach, M. and Lewin, G.R.
Cell Reports 17 (3): 748-758. 11 October 2016

Measurement of vibration detection threshold and tactile spatial acuity in human subjects.
Moshourab, R., Frenzel, H., Lechner, S., Haseleu, J., Bégay, V., Omerbašić, D. and Lewin, G.R.
Journal of Visualized Experiments (115): e52966. 1 September 2016

A molecular signature of myalgia in myotonic dystrophy 2.
Moshourab, R., Palada, V., Grunwald, S., Grieben, U., Lewin, G.R. and Spuler, S.
EBioMedicine 7 : 205-211. May 2016

Structural decoding of the netrin-1/UNC5 interaction and its therapeutical implications in cancers.
Grandin, M., Meier, M., Delcros, J.G., Nikodemus, D., Reuten, R., Patel, T.R., Goldschneider, D., Orriss, G., Krahn, N., Boussouar, A., Abes, R., Dean, Y., Neves, D., Bernet, A., Depil, S., Schneiders, F., Poole, K., Dante, R., Koch, M., Mehlen, P. and Stetefeld, J.
Cancer Cell 29 (2): 173-185. 8 February 2016

Structural changes and lack of HCN1 channels in the binaural auditory brainstem of the naked mole-rat (Heterocephalus glaber).
Gessele, N., Garcia-Pino, E., Omerbasic, D., Park, T.J. and Koch, U.
PLoS ONE 11 (1): e0146428. 13 January 2016

2015

A probabilistic model for estimating the depth and threshold temperature of C-fiber nociceptors.
Dezhdar, T., Moshourab, R.A., Fründ, I., Lewin, G.R. and Schmuker, M.
Scientific Reports 5 : 17670. 7 December 2015

ASICs and mammalian mechanoreceptor function.
Omerbašić, D., Schuhmacher, L.N., Bernal Sierra, Y.A., Smith, E.S.J. and Lewin, G.R.
Neuropharmacology 94 : 80-86. July 2015

Photoswitchable fatty acids enable optical control of TRPV1.
Frank, J.A., Moroni, M., Moshourab, R., Sumser, M., Lewin, G.R. and Trauner, D.
Nature Communications 6 : 7118. 21 May 2015

GABA blocks pathological but not acute TRPV1 pain signals.
Hanack, C., Moroni, M., Lima, W.C., Wende, H., Kirchner, M., Adelfinger, L., Schrenk-Siemens, K., Tappe-Theodor, A., Wetzel, C., Kuich, P.H., Gassmann, M., Roggenkamp, D., Bettler, B., Lewin, G.R., Selbach, M. and Siemens, J.
Cell 160 (4): 759-770. 12 February 2015

Sensory mechanotransduction at membrane-matrix interfaces.
Poole, K., Moroni, M. and Lewin, G.R.
Pfluegers Archiv European Journal of Physiology 467 (1): 121-132. 15 January 2015

PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors.
Schrenk-Siemens, K., Wende, H., Prato, V., Song, K., Rostock, C., Loewer, A., Utikal, J., Lewin, G.R., Lechner, S.G. and Siemens, J.
Nature Neuroscience 18 (1): 10-16. January 2015

2014

Piezo2 is the major transducer of mechanical forces for touch sensation in mice.
Ranade, S.S., Woo, S.H., Dubin, A.E., Moshourab, R.A., Wetzel, C., Petrus, M., Mathur, J., Bégay, V., Coste, B., Mainquist, J., Wilson, A.J., Francisco, A.G., Reddy, K., Qiu, Z., Wood, J.N., Lewin, G.R. and Patapoutian, A.
Nature 516 (7529): 121-125. 4 December 2014

A somatosensory circuit for cooling perception in mice.
Milenkovic, N., Zhao, W.J., Walcher, J., Albert, T., Siemens, J., Lewin, G.R. and Poulet, J.F.A.
Nature Neuroscience 17 (11): 1560-1566. November 2014

Inhibition of c-Kit signaling is associated with reduced heat and cold pain sensitivity in humans.
Ceko, M., Milenkovic, N., Le Coutre, P., Westermann, J. and Lewin, G.R.
Pain 155 (7): 1222-1228. July 2014

Tuning piezo ion channels to detect molecular-scale movements relevant for fine touch.
Poole, K., Herget, R., Lapatsina, L., Ngo, H.D. and Lewin, G.R.
Nature Communications 5 : 3520. 24 March 2014

Subunit-specific inhibition of acid sensing ion channels by stomatin-like protein 1.
Kozlenkov, A., Lapatsina, L., Lewin, G.R. and Smith, E.S.J.
Journal of Physiology 592 (Pt 4): 557-569. 15 February 2014

Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination.
Sheean, M.E., McShane, E., Cheret, C., Walcher, J., Müller, T., Wulf-Goldenberg, A., Hoelper, S., Garratt, A.N., Krüger, M., Rajewsky, K., Meijer, D., Birchmeier, W., Lewin, G.R., Selbach, M. and Birchmeier, C.
Genes & Development 28 (3): 290-303. 1 February 2014

Pro-neurotrophins, sortilin, and nociception.
Lewin, G.R. and Nykjaer, A.
European Journal of Neuroscience 39 (3): 363-374. February 2014

Water-induced finger wrinkles do not affect touch acuity or dexterity in handling wet objects.
Haseleu, J., Omerbašić, D., Frenzel, H., Gross, M. and Lewin, G.R.
PLoS ONE 9 (1): e84949. 8 January 2014

Nerve growth factor and nociception: from experimental embryology to new analgesic therapy.
Lewin, G.R., Lechner, S.G. and Smith, E.S.J.
Handbook of Experimental Pharmacology 220 : 251-282. 2014

Neurotrophic factors.
Lewin, G.R. and Carter, B.D., eds.
Handbook of Experimental Pharmacology, 220 . Springer, Berlin [u.a.]. ISBN 978-3-642-45105-8 2014

Preface.
Lewin, G.R. and Carter, B.D.
Handbook of Experimental Pharmacology 220 : v-vi. 2014

2013

Stomatin-domain protein interactions with acid sensing ion channels modulate nociceptor mechanosensitivity.
Moshourab, R.A., Wetzel, C., Martinez-Salgado, C. and Lewin, G.R.
Journal of Physiology 591 (Pt 22): 5555-5574. 15 November 2013

Natural selection and pain meet at a sodium channel.
Lewin, G.R.
Science 342 (6157): 428-429. 25 October 2013

Hairy sensation.
Lechner, S.G. and Lewin, G.R.
Physiology 28 (3): 142-150. May 2013

2012

The transcription factor c-Maf in sensory neuron development.
Wende, H., Lechner, S.G. and Birchmeier, C.
Transcription 3 (6): 285-289. November 2012

A stomatin dimer modulates the activity of acid-sensing ion channels.
Brand, J., Smith, E.S.J., Schwefel, D., Lapatsina, L., Poole, K., Omerbasic, D., Kozlenkov, A., Behlke, J., Lewin, G.R. and Daumke, O.
EMBO Journal 31 (17): 3635-3646. 29 August 2012

Specific paucity of unmyelinated C-fibers in cutaneous peripheral nerves of the African naked-mole rat: comparative analysis using six species of bathyergidae.
Smith, E.S.J., Purfürst, B., Grigoryan, T., Park, T.J., Bennett, N.C. and Lewin, G.R.
Journal of Comparative Neurology 520 (12): 2785-2803. 15 August 2012

Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1.
Stock, K., Kumar, J., Synowitz, M., Petrosino, S., Imperatore, R., Smith, E.S.J., Wend, P., Purfürst, B., Nuber, U.A., Gurok, U., Matyash, V., Waelzlein, J.H., Chirasani, S.R., Dittmar, G., Cravatt, B.F., Momma, S., Lewin, G.R., Ligresti, A., De Petrocellis, L., Cristino, L., Di Marzo, V., Kettenmann, H. and Glass, R.
Nature Medicine 18 (8): 1232-1238. August 2012

Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons.
Lapatsina, L., Jira, J.A., Smith, E.S.J., Poole, K., Kozlenkov, A., Bilbao, D., Lewin, G.R. and Heppenstall, P.A.
Open Biology 2 (6): 120096. 27 June 2012

A genetic basis for mechanosensory traits in humans.
Frenzel, H., Bohlender, J., Pinsker, K., Wohlleben, B., Tank, J., Lechner, S.G., Schiska, D., Jaijo, T., Rueschendorf, F., Saar, K., Jordan, J., Millan, J.M., Gross, M. and Lewin, G.R.
PLoS Biology 10 (5): e1001318. 1 May 2012

Stomatin-domain proteins.
Lapatsina, L., Brand, J., Poole, K., Daumke, O. and Lewin, G.R.
European Journal of Cell Biology 91 (4): 240-245. April 2012

The transcription factor c-Maf controls touch receptor development and function.
Wende, H., Lechner, S.G., Cheret, C., Bourane, S., Kolanczyk, M.E., Pattyn, A., Reuter, K., Munier, F.L., Carroll, P., Lewin, G.R. and Birchmeier, C.
Science 335 (6074): 1373-1376. 16 March 2012

Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity.
Luo, C., Gangadharan, V., Bali, K.K., Xie, R.G., Agarwal, N., Kurejova, M., Tappe-Theodor, A., Tegeder, I., Feil, S., Lewin, G., Polgar, E., Todd, A.J., Schlossmann, J., Hofmann, F., Liu, D.L., Hu, S.J., Feil, R., Kuner, T. and Kuner, R.
PLoS Biology 10 (3): e1001283. 13 March 2012

Gα(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization.
Tappe-Theodor, A., Constantin, C.E., Tegeder, I., Lechner, S.G., Langeslag, M., Lepcynzsky, P., Wirotanseng, R.I., Kurejova, M., Agarwal, N., Nagy, G., Todd, A., Wettschureck, N., Offermanns, S., Kress, M., Lewin, G.R. and Kuner, R.
Pain 153 (1): 184-196. January 2012

KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man.
Heidenreich, M., Lechner, S.G., Vardanyan, V., Wetzel, C., Cremers, C.W., De Leenheer, E.M., Aranguez, G., Moreno-Pelayo, M.A., Jentsch, T.J. and Lewin, G.R.
Nature Neuroscience 15 (1): 138-145. 2012

2011

The molecular basis of acid insensitivity in the African naked mole-rat.
Smith, E.S.J., Omerbasic, D., Lechner, S.G., Anirudhan, G., Lapatsina, L. and Lewin, G.R.
Science 334 (6062): 1557-1560. 16 December 2011

Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons.
Chiang, L.Y., Poole, K., Oliveira, B.E., Duarte, N., Bernal Sierra, Y.A., Bruckner-Tuderman, L., Koch, M., Hu, J. and Lewin, G.R.
Nature Neuroscience 14 (8): 993-1000. 3 July 2011

The Cav3.2 T-type calcium channel regulates temporal coding in mouse mechanoreceptors.
Wang, R. and Lewin, G.R.
Journal of Physiology 589 (9): 2229-2243. 1 May 2011

Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice.
Gangadharan, V., Wang, R., Ulzhoefer, B., Luo, C., Bardoni, R., Bali, K.K., Agarwal, N., Tegeder, I., Hildebrandt, U., Nagy, G.G., Todd, A.J., Ghirri, A., Haeussler, A., Sprengel, R., Seeburg, P.H., Macdermott, A.B., Lewin, G.R. and Kuner, R.
Journal of Clinical Investigation 121 (4): 1608-1623. 1 April 2011

Sensory transduction, the gateway to perception: mechanisms and pathology.
Lechner, S.G. and Siemens, J.
EMBO Reports 12 (4): 292-295. 1 April 2011

The molecular and cellular identity of peripheral osmoreceptors.
Lechner, S.G., Markworth, S., Poole, K., Smith, E.S.J., Lapatsina, L., Frahm, S., May, M., Pischke, S., Suzuki, M., Ibanez-Tallon, I., Luft, F.C., Jordan, J. and Lewin, G.R.
Neuron 69 (2): 332-344. 27 January 2011

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.
Vaegter, C.B., Jansen, P., Fjorback, A.W., Glerup, S., Skeldal, S., Kjolby, M., Richner, M., Erdmann, B., Nyengaard, J.R., Tessarollo, L., Lewin, G.R., Willnow, T.E., Chao, M.V. and Nykjaer, A.
Nature Neuroscience 14 (1): 54-61. January 2011

2010

Functional neurokinin and NMDA receptor activity in an animal naturally lacking Substance P: the naked mole-rat.
Brand, A., Smith, E.S.J., Lewin, G.R. and Park, T.J.
PLoS ONE 5 (12): e15162. 21 December 2010

Naked mole rats: their extraordinary sensory world.
Park, T.J., Lewin, G.R. and Buffenstein, R.
In: Encyclopedia of Animal Behavior. Reference Module in Life Sciences . Academic Press, 505-512. ISBN 978-0-08-045337-8 12 July 2010

Ultraviolet-B-induced mechanical hyperalgesia: A role for peripheral sensitisation.
Bishop, T., Marchand, F., Young, A.R., Lewin, G.R. and McMahon, S.B.
Pain 150 (1): 141-152. July 2010

Absence of histamine-induced itch in the African naked mole-rat and "rescue" by Substance P.
Smith, E.S.J., Blass, G.R., Lewin, G.R. and Park, T.J.
Molecular Pain 6 (1): 29. 24 May 2010

An in vivo tethered toxin approach for the cell-autonomous inactivation of voltage-gated sodium channel currents in nociceptors.
Stuerzebecher, A.S., Hu, J., Smith, E.S.J., Frahm, S., Santos-Torres, J., Kampfrath, B., Auer, S., Lewin, G.R. and Ibanez-Tallon, I.
Journal of Physiology 588 (Pt 10): 1695-1707. 15 May 2010

Evidence for a protein tether involved in somatic touch.
Hu, J., Chiang, L.Y., Koch, M. and Lewin, G.R.
EMBO Journal 29 (4): 855-867. 17 February 2010

2009

Nociceptors: a phylogenetic view.
Smith, E.S.J. and Lewin, G.R.
Journal of Comparative Physiology A 195 (12): 1089-1106. December 2009

Peripheral sensitisation of nociceptors via G-protein dependent potentiation of mechanotransduction currents.
Lechner, S.G. and Lewin, G.R.
Journal of Physiology 587 (Pt 14): 3493-3503. 15 July 2009

Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.
Lechner, S.G., Frenzel, H., Wang, R. and Lewin, G.R.
EMBO Journal 28 (10): 1479-1491. 20 May 2009

2008

Speed and temperature dependence of mechanotransduction in in afferent fibers recorded from the mouse saphenous nerve.
Milenkovic, N., Wetzel, C., Moshourab, R. and Lewin, G.R.
Journal of Neurophysiology 100 (5): 2771-2783. 1 November 2008

Stretching it for pain.
Lewin, G.R.
Pain 137 (1): 3-4. July 2008

Persistent pain: the contribution of NaV1.9.
Smith, E.S.J. and Momin, A.
Journal of Physiology 586 (9): 2249-2250. May 2008

Probing cellular microenvironments and tissue remodeling by atomic force microscopy.
Ludwig, T., Kirmse, R., Poole, K. and Schwarz, U.S.
Pfluegers Archiv European Journal of Physiology 456 (1): 29-49. April 2008

Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber).
Park, T.J., Lu, Y., Jüttner, R., Smith, E.S.J., Hu, J., Brand, A., Wetzel, C., Milenkovic, N., Erdmann, B., Heppenstall, P.A., Laurito, C.E., Wilson, S.P. and Lewin, G.R.
PLoS Biology 6 (1): e13. 29 January 2008

2007

Nociceptive tuning by stem cell factor/c-Kit signaling.
Milenkovic, N., Frahm, C., Gassmann, M., Griffel, C., Erdmann, B., Birchmeier, C., Lewin, G.R. and Garratt, A.N.
Neuron 56 (5): 893-906. 6 December 2007

Stomatin and sensory neuron mechanotransduction.
Martinez-Salgado, C., Benckendorff, A.G., Chiang, L.Y., Wang, R., Milenkovic, N., Wetzel, C., Hu, J., Stucky, C.L., Parra, M.G., Mohandas, N. and Lewin, G.R.
Journal of Neurophysiology 98 (6): 3802-3808. 1 December 2007

Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.
Jansen, P., Giehl, K., Nyengaard, J.R., Teng, K., Lioubinski, O., Sjoegaard, S.S., Breiderhoff, T., Gotthardt, M., Lin, F., Eilers, A., Petersen, C.M., Lewin, G.R., Hempstead, B.L., Willnow, T.E. and Nykjaer, A.
Nature Neuroscience 10 (11): 1449-1457. November 2007

A stomatin-domain protein essential for touch sensation in the mouse.
Wetzel, C., Hu, J., Riethmacher, D., Benckendorff, A., Harder, L., Eilers, A., Moshourab, R., Kozlenkov, A., Labuz, D., Caspani, O., Erdmann, B., Machelska, H., Heppenstall, P.A. and Lewin, G.R.
Nature 445 (7124): 206-209. 11 January 2007

2006

Mechanosensitive currents in the neurites of cultured mouse sensory neurones.
Hu, J. and Lewin, G.R.
Journal of Physiology 577 (Pt.3): 815-828. 15 December 2006

A role for T-type Ca2+ channels in mechanosensation.
Heppenstall, P.A. and Lewin, G.R.
Cell Calcium 40 (2): 165-174. August 2006

The high threshold mechanotransducer: A status report.
Hu, J., Milenkovic, N. and Lewin, G.R.
Pain 120 (1-2): 3-7. January 2006

Finding sensory neuron mechanotransduction components.
Boensch, R. and Lewin, G.R.
2006

2005

The sensory mechanotransduction ion channel ASIC2 (acid sensitive ion channel 2) is regulated by neurotrophin availability.
McIlwrath, S.L., Hu, J., Anirudhan, G., Shin, J.B. and Lewin, G.R.
Neuroscience 131 (2): 499-511. 1 January 2005

2004

The AMPA receptor subunits GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain.
Hartmann, B., Ahmadi, S., Heppenstall, P.A., Lewin, G.R., Schott, C., Borchardt, T., Seeburg, P.H., Zeilhofer, H.U., Sprengel, R. and Kuner, R.
Neuron 44 (4): 637-650. 18 November 2004

Role of T-type calcium current in identified D-hair mechanoreceptor neurons studied in vitro.
Dubreuil, A.S., Boukhaddaoui, H., Desmadryl, G., Martinez-Salgado, C., Moshourab, R., Lewin, G.R., Carroll, P., Valmier, J. and Scamps, F.
Journal of Neuroscience 24 (39): 8480-8484. 29 September 2004

A plethora of painful molecules.
Lewin, G.R., Lu, Y. and Park, T.J.
Current Opinion in Neurobiology 14 (4): 443-449. 1 August 2004

Method for identifying compounds which inhibit mechanotransduction in neurons [Verfahren zur Identifizierung von Substanzen, die Mechanotransduktion in Neuronen hemmen].
Lewin, G.R., Heppenstall, P.A. and Eilers, A.
WO0440299 ; EP1556693 ; US60/422,098. 13 May 2004

Mittel zur medikamentoesen Behandlung von akuten und chronischen Schmerzen [Agent for medicamentous treatment of acute and chronic pain].
Lewin, G.R. and Shin, J.B.
DE10227511A1 ; EP1549307 ; WO04000311. 8 January 2004

Mechanosensation and pain.
Lewin, G.R. and Moshourab, R.
Journal of Neurobiology 61 : 30-44. 1 January 2004

The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function.
Page, A.J., Brierley, S.M., Martin, C.M., Martinez-Salgado, C., Wemmie, J.A., Brennan, T.J., Symonds, E., Omari, T., Lewin, G.R., Welsh, M.J. and Blackshaw, L.A.
Gastroenterology 127 (6): 1739-1747. 1 January 2004

2003

Pharmaceutical composition comprising calcium channel blockers for the treatment of pain.
Lewin, G.R. and Shin, J.B.
WO0400311. 31 December 2003

A T-type calcium channel required for normal function of a mammalian mechanoreceptor.
Shin, J.B., Martinez-Salgado, C., Heppenstall, P.A. and Lewin, G.R.
Nature Neuroscience 6 (7): 724-730. July 2003

Identification of caveolae-like structures on the surface of intact cells using scanning force microscopy.
Lucius, H., Friedrichson, T., Kurzchalia, T.V. and Lewin, G.R.
Journal of Membrane Biology 194 (2): 97-108. June 2003

Duplication of the MID1 first exon in a patient with Opitz G/BBB syndrome.
Winter, J., Lehmann, T., Suckow, V., Kijas, Z., Kulozik, A., Kalscheuer, V., Hamel, B., Devriendt, K., Opitz, J., Lenzner, S., Ropers, H.H. and Schweiger, S.
Human Genetics 112 (3): 249-254. March 2003

2002

cGMP-mediated signaling via cGKIαs required for the guidance and connectivity of sensory axons.
Schmidt, H., Werner, M., Heppenstall, P.A., Henning, M., More, M.I., Kuehbandner, S., Lewin, G.R., Hofmann, F., Feil, R. and Rathjen, F.G.
Journal of Cell Biology 159 (3): 489-498. 11 November 2002

GFR α2/neurturin signalling regulates noxious heat transduction in isolectin B4- binding mouse sensory neurons.
Stucky, C.L., Rossi, J., Airaksinen, M.S. and Lewin, G.R.
Journal of Physiology 545 (1): 43-50. November 2002

Neurotrophin-4: a survival factor for adult sensory neurons.
Stucky, C.L., Shin, J.B. and Lewin, G.R.
Current Biology 12 (16): 1401-1404. 20 August 2002

The homeodomain factor Lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord.
Müller, T., Brohmann, H., Pierani, A., Heppenstall, P.A., Lewin, G.R., Jessell, T.M. and Birchmeier, C.
Neuron 34 (4): 551-562. 16 May 2002

Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons.
Postigo, A., Calella, A.M., Fritzsch, B., Knipper, M., Katz, D., Eilers, A., Schimmang, T., Lewin, G.R., Klein, R. and Minichiello, L.
Genes & Development 16 (5): 633-645. 1 January 2002

2001

The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice.
Price, M.P., McIlwrath, S.L., Xie, J.H., Cheng, C., Qiao, J., Tarr, D.E., Sluka, K.A., Brennan, T.J., Lewin, G.R. and Welsh, M.J.
Neuron 32 (6): 1071-1083. 20 December 2001

BDNF but not NT-4 is required for normal flexion reflex plasticity and function.
Heppenstall, P.A. and Lewin, G.R.
Proceedings of the National Academy of Sciences of the United States of America 98 (14): 8107-8112. 3 July 2001

Lack of neurotrophin-4 causes selective structural and chemical deficits in sympathetic ganglia and their preganglionic innervation.
Roosen, A., Schober, A., Strelau, J., Boettner, M., Faulhaber, J., Bendner, G., McIlwrath, S.L., Seller, H., Ehmke, H., Lewin, G.R. and Unsicker, K.
Journal of Neuroscience 21 (9): 3073-3084. 1 May 2001

Selective activation of nociceptors by P2X receptor agonists in normal and inflamed rat skin.
Hamilton, S.G., McMahon, S.B. and Lewin, G.R.
Journal of Physiology 534 (2): 437-445. 1 January 2001

2000

The mammalian sodium channel BNC1 is required for normal touch sensation.
Price, M.P., Lewin, G.R., McIlwrath, S.L., Cheng, C., Xie, J.H., Heppenstall, P.A., Stucky, C.L., Mannsfeldt, A.G., Brennan, T.J., Drummond, H.A., Qiao, J., Benson, C.J., Tarr, D.E., Hrstka, R.F., Yang, B.L., Williamson, R.A. and Welsh, M.J.
Nature 407 (6807): 1007-1011. 26 October 2000

Neurotrophins, nociceptors and pain.
Heppenstall, P.A. and Lewin, G.R.
Current Opinion in Anaesthesiology 13 (5): 573-576. October 2000

Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors.
Pesquero, J.B., Araujo, R.C., Heppenstall, P.A., Stucky, C.L., Silva, J.A., Walther, T., Oliveira, S.M., Pesquero, J.L., Paiva, A.C.M., Calixto, J.B., Lewin, G.R. and Bader, M.
Proceedings of the National Academy of Sciences of the United States of America 97 (14): 8140-8145. 5 July 2000

Proteine der Stomatinfamilie und ihre Verwendung als Zielproteine fuer die Schmerztherapie.
Mannsfeldt, A.G. and Lewin, G.R.
DE19850015A1. 4 May 2000

1999

Abundant production of brain-derived neurotrophic factor by adult visceral epithelia - Implications for paracrine and target-derived neurotrophic functions.
Lommatzsch, M., Braun, A., Mannsfeldt, A., Botchkarev, V.A., Botchkareva, N.V., Paus, R., Fischer, A., Lewin, G.R. and Renz, H.
American Journal of Pathology 155 (4): 1183-1193. 1 October 1999

Cellular sources of enhanced brain-derived neurotrophic factor production in a mouse model of allergic inflammation.
Braun, A., Lommatzsch, M., Mannsfeldt, A., Neuhaus-Steinmetz, U., Fischer, A., Schnoy, N., Lewin, G.R. and Renz, H.
American Journal of Respiratory Cell and Molecular Biology 21 : 537-546. 1 October 1999

Isolectin B4-positive and -negative nociceptors are functionally distinct.
Stucky, C.L. and Lewin, G.R.
Journal of Neuroscience 19 (15): 6497-6505. 1 August 1999

Stomatin, a MEC-2 like protein, is expressed by mammalian sensory neurons.
Mannsfeldt, A.G., Carroll, P., Stucky, C.L. and Lewin, G.R.
Molecular and Cellular Neuroscience 13 (6): 391-404. 1 June 1999

A new role for neurotrophins: involvement of brain-derived neurotrophic factor and neurotrophin-4 in hair cycle control.
Botchkarev, V.A., Botchkareva, N.V., Welker, P., Metz, M., Lewin, G.R., Subramaniam, A., Bulfone-Paus, S., Hagen, E., Braun, A., Lommatzsch, M., Renz, H. and Paus, R.
FASEB Journal 13 : 395-410. 1 February 1999

Stability and plasticity of primary afferent projections following nerve regeneration and central degeneration.
Belyantseva, I.A. and Lewin, G.R.
European Journal of Neuroscience 11 : 457-468. 1 February 1999

Neurotrophins: a link between airway inflammation and airway smooth muscle contractility in asthma?
Braun, A., Lommatzsch, M., Lewin, G.R., Virchow, J.C. and Renz, H.
International Archives of Allergy and Immunology 118 (2-4): 163-165. February 1999

1998

BDNF overexpression induces differential increases among subsets of sympathetic innervation in murine back skin.
Botchkarev, V.A., Botchkareva, N.V., Lommatzsch, M., Peters, E.M.J., Lewin, G.R., Subramaniam, A., Braun, A., Renz, H. and Paus, R.
European Journal of Neuroscience 10 : 3276-3283. 1 October 1998

TrkB and neurotrophin-4 are important for development and maintenance of sympathetic preganglionic neurons innervating the adrenal medulla.
Schober, A., Wolf, N., Huber, K., Hertel, R., Krieglstein, K., Minichiello, L., Kahane, N., Widenfalk, J., Kalcheim, C., Olson, L., Klein, R., Lewin, G.R. and Unsicker, K.
Journal of Neuroscience 18 (18): 7272-7284. 15 September 1998

A new role for neurotrophin-3: Involvement in the regulation of hair follicle regression (catagen).
Botchkarev, V.A., Welker, P., Albers, K.M., Botchkareva, N.V., Metz, M., Lewin, G.R., Bulfone-Paus, S., Peters, E.M., Lindner, G. and Paus, R.
American Journal of Pathology 153 : 785-799. 1 September 1998

Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses.
Minichiello, L., Casagranda, F., Tatche, R.S., Stucky, C.L., Postigo, A., Lewin, G.R., Davies, A.M. and Klein, R.
Neuron 21 : 335-345. 1 August 1998

A role for BDNF in mechanosensation.
Carroll, P., Lewin, G.R., Koltzenburg, M., Toyka, K.V. and Thoenen, H.
Nature Neuroscience 1 : 42-46. 1 May 1998

Neurotrophin-3 involvement in the regulation of hair follicle morphogenesis.
Botchkarev, V.A., Botchkareva, N.V., Albers, K.M., van der Veen, C., Lewin, G.R. and Paus, R.
Journal of Investigative Dermatology 111 : 279-285. 1 January 1998

1997

Severe neuropathies in mice with targeted mutations in the ErbB3 receptor.
Riethmacher, D., Sonnenberg-Riethmacher, E., Brinkmann, V., Yamaai, T., Lewin, G.R. and Birchmeier, C.
Nature 389 (6652): 725-730. 16 October 1997

Der Einfluss von Neutrophinen auf den Phaenotyp sensorischer Neurone.
Koltzenburg, M. and Lewin, G.R.
Neuroforum 3, Heft 1 : 27-31. 1 January 1997

Neurotrophins live or let die: Does p75NTR decide.
Carter, B.D. and Lewin, G.R.
Neuron 18 : 187-190. 1 January 1997

Receptive properties of embryonic chick sensory neurons innervating skin.
Koltzenburg, M. and Lewin, G.R.
Journal of Neurophysiology 78 : 2560-2568. 1 January 1997

Receptive properties of mouse sensory neurons innervating hairy skin.
Koltzenburg, M., Stucky, C.L. and Lewin, G.R.
Journal of Neurophysiology 78 : 1841-1850. 1 January 1997

1996

Physiology of the neurotrophins.
Lewin, G.R. and Barde, Y.A.
Annual Review of Neuroscience 19 : 289-317. March 1996

Maintenance of modality-specific connections in the spinal cord after neonatal nerve growth factor deprivation.
Lewin, G.R. and Mendell, L.M.
European Journal of Neuroscience 8 : 1677-1684. 1 January 1996

Neurotrophins and the specification of neuronal phenotype.
Lewin, G.R.
Philosophical Transactions of the Royal Society of London Series B Biological Sciences 351 : 405-411. 1 January 1996

Roles of neurotrophin-3 during early development of the peripheral nervous system.
Ockel, M., von Schack, D., Schroepel, A., Dechant, G., Lewin, G.R. and Barde, Y.A.
Philosophical Transactions of the Royal Society of London Series B Biological Sciences 351 : 383-387. 1 January 1996

Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation.
Airaksinen, M.S., Koltzenburg, M., Lewin, G.R., Masu, Y., Helbig, C., Wolf, E., Brem, G., Toyka, K.V., Thoenen, H. and Meyer, M.
Neuron 16 : 287-295. 1 January 1996

In vivo effects of neurotrophin-3 during sensory neurogenesis.
Ockel, M., Lewin, G.R. and Barde, Y.A.
Development 122 (1): 301-307. January 1996

1995

Neurotropic Factors and Pain.
Lewin, G.R.
Seminars in the Neurosciences 7 : 227-232. 1 January 1995

1994

Peripheral and central mechanisms of NGF-induced hyperalgesia.
Lewin, G.R., Rueff, A. and Mendell, L.M.
European Journal of Neuroscience 6 (12): 1903-1912. 1 December 1994

NMDA receptors and activity-dependent tuning of the receptive fields of spinal cord neurons.
Lewin, G.R., Mckintosh, E. and McMahon, S.B.
Nature 369 (6480): 482-485. 9 June 1994

Regulation of cutaneous C-fiber heat nociceptors by nerve growth factor in the developing rat.
Lewin, G.R. and Mendell, L.M.
Journal of Neurophysiology 71 (3): 941-949. 1 March 1994

An ultrastructural size principle.
Pierce, J.P. and Lewin, G.R.
Neuroscience 58 (3): 441-446. 1 February 1994

1993

Altered expression of nerve growth factor in the skin of transgenic mice leads to changes in response to mechanical stimuli.
Davis, B.M., Lewin, G.R., Mendell, L.M., Jones, M.E. and Albers, K.M.
Neuroscience 56 (4): 789-792. 1 October 1993

Nerve growth factor and nociception.
Lewin, G.R. and Mendell, L.M.
Trends in Neurosciences 16 : 353-359. 1 September 1993

Muscle afferents innervating skin form somatotopically appropriate connections in the adult rat dorsal horn.
Lewin, G.R. and McMahon, S.B.
European Journal of Neuroscience 5 : 1083-1092. 1 August 1993

Nerve growth factor-induced hyperalgesia in the neonatal and adult rat.
Lewin, G.R., Ritter, A.M. and Mendell, L.M.
Journal of Neuroscience 13 (5): 2136-2148. May 1993

Regulation of myelinated nociceptor function by nerve growth factor in neonatal and adult rats.
Ritter, A.M., Lewin, G.R. and Mendell, L.M.
Brain Research Bulletin 30 : 245-249. 1 January 1993

1992

On the role of nerve growth factor in the development of myelinated nociceptors.
Lewin, G.R., Ritter, A.M. and Mendell, L.M.
Journal of Neuroscience 12 (5): 1896-1905. May 1992

Neonatal Anit-Ngf treatment reduces the Adelta-and c-fibre evoked vasodilator responses in rat skin: evidence that nociceptor afferents mediate antidromic vasodilatation.
Lewin, G.R., Lisney, S.J.W. and Mendell, L.M.
European Journal of Neuroscience 4 : 1213-1218. 1 January 1992

Regulation of afferent connectivity in the adult spinal-cord by nerve growth factor.
Lewin, G.R., Winter, J. and McMahon, S.B.
European Journal of Neuroscience 4 : 700-707. 1 January 1992