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2024

Arginine methylation of the p30 C/EBPα oncoprotein regulates progenitor proliferation and myeloid differentiation.
Nguyen, L.T., Zimmermann, K., Kowenz-Leutz, E., Dörr, D., Schütz, A., Schönheit, J., Mildner, A. and Leutz, A.
iScience 27 (11): 111199. 15 November 2024

2023

C/EBPβ-induced lymphoid-to-myeloid transdifferentiation emulates granulocyte-monocyte progenitor biology.
Nguyen, L.T., Zimmermann, K., Kowenz-Leutz, E., Lim, R., Hofstätter, M., Mildner, A. and Leutz, A.
Stem Cell Reports 19 (1): 112-125. 28 December 2023

Carm1-arginine methylation of the transcription factor C/EBPα regulates transdifferentiation velocity.
Torcal Garcia, G., Kowenz-Leutz, E., Tian, T.V, Klonizakis, A., Lerner, J., De Andres-Aguayo, L., Sapozhnikova, V., Berenguer, C., Carmona, M.P., Casadesus, M.V., Bulteau, R., Francesconi, M., Peiro, S., Mertins, P., Zaret, K., Leutz, A. and Graf, T.
eLife 12 : e83951. 27 June 2023

2022

Identification of environmental factors that promote intestinal inflammation.
Sanmarco, L.M., Chao, C.C., Wang, Y.C., Kenison, J.E., Li, Z., Rone, J.M., Rejano-Gordillo, C.M., Polonio, C.M., Gutierrez-Vazquez, C., Piester, G., Plasencia, A., Li, L., Giovannoni, F., Lee, H.G., Faust Akl, C., Wheeler, M.A., Mascanfroni, I., Jaronen, M., Alsuwailm, M., Hewson, P., Yeste, A., Andersen, B.M., Franks, D.G., Huang, C.J., Ekwudo, M., Tjon, E.C., Rothhammer, V., Takenaka, M., de Lima, K.A., Linnerbauer, M., Guo, L., Covacu, R., Queva, H., Fonseca-Castro, P.H., Bladi, M.A., Cox, L.M., Hodgetts, K.J., Hahn, M.E., Mildner, A., Korzenik, J., Hauser, R., Snapper, S.B. and Quintana, F.J.
Nature 611 (7937): 801-809. 24 November 2022

Immune cell C/EBPβ deficiency is associated with hepatic mononuclear defects and spontaneous hepatitis but not steatohepatitis induced liver fibrosis.
Moshkovits, I., Kaminitz, A., Reuveni, D., Pasmanik-Chor, M., Brazowski, E., Mildner, A., Leutz, A. and Zigmond, E.
Immunity, inflammation and disease 10 (11): e728. November 2022

C/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages.
Dörr, D., Obermayer, B., Weiner, J.M., Zimmermann, K., Anania, C., Wagner, L.K., Lyras, E.M., Sapozhnikova, V., Lara-Astiaso, D., Prósper, F., Lang, R., Lupiáñez, D.G., Beule, D., Höpken, U.E., Leutz, A. and Mildner, A.
Science Immunology 7 (75): eabj0140. September 2022

CSF2-dependent monocyte education in the pathogenesis of ANCA-induced glomerulonephritis.
Rousselle, A., Sonnemann, J., Amann, K., Mildner, A., Lodka, D., Kling, L., Bieringer, M., Schneider, U., Leutz, A., Enghard, P., Kettritz, R. and Schreiber, A.
Annals of the Rheumatic Diseases 81 (8): 1162-1172. August 2022

Tongue immune compartment analysis reveals spatial macrophage heterogeneity.
Lyras, E.M., Zimmermann, K., Wagner, L.K., Dörr, D., Klose, C.S.N, Fischer, C., Jung, S., Yona, S., Hovav, A.H., Stenzel, W., Dommerich, S., Conrad, T., Leutz, A. and Mildner, A.
eLife 11 : 77490. 24 June 2022

Downregulation of odd-skipped related 2, a novel regulator of epithelial-mesenchymal transition, enables efficient somatic cell reprogramming.
Anh, L.P.H., Nishimura, K., Kuno, A., Nguyen, T.L., Kato, T., Ohtaka, M., Nakanishi, M., Sugihara, E., Sato, T.A., Hayashi, Y., Fukuda, A. and Hisatake, K.
Stem Cells 40 (4): 397-410. 29 April 2022

2021

A universal peptide matrix interactomics approach to disclose motif dependent protein binding.
Ramberger, E., Suarez-Artiles, L., Perez-Hernandez, D., Haji, M., Popp, O., Reimer, U., Leutz, A., Dittmar, G. and Mertins, P.
Molecular & Cellular Proteomics 20 : 100135. 13 August 2021

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.
Ramberger, E., Sapozhnikova, V., Kowenz-Leutz, E., Zimmermann, K., Nicot, N., Nazarov, P.V., Perez-Hernandez, D., Reimer, U., Mertins, P., Dittmar, G. and Leutz, A.
iScience 24 (6): 102686. 25 June 2021

Editorial: Monocyte heterogeneity and function.
Ginhoux, F., Mildner, A., Gautier, E.L., Schlitzer, A., Jakubzick, C., Varol, C., Bain, C. and Guermonprez, P.
Frontiers in Immunology 11 : 626725. 7 January 2021

Myeloid transformation by MLL-ENL depends strictly on C/EBP.
Wesolowski, R., Kowenz-Leutz, E., Zimmermann, K., Dörr, D., Hofstätter, M., Slany, R.K., Mildner, A. and Leutz, A.
Life Science Alliance 4 (1): e202000709. January 2021

2020

The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.
Scholz, F., Grau, M., Menzel, L., Graband, A., Zapukhlyak, M., Leutz, A., Janz, M., Lenz, G., Rehm, A. and Höpken, U.E.
Proceedings of the National Academy of Sciences of the United States of America 117 (42): 26328-26339. 20 October 2020

C/EBPβ-dependent epigenetic memory induces trained immunity in hematopoietic stem cells.
de Laval, B., Maurizio, J., Kandalla, P.K., Brisou, G., Simonnet, L., Huber, C., Gimenez, G., Matcovitch-Natan, O., Reinhardt, S., David, E., Mildner, A., Leutz, A., Nadel, B., Bordi, C., Amit, I., Sarrazin, S. and Sieweke, M.H.
Cell Stem Cell 26 (5): 657-674. May 2020

Cxcl10(+) monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation.
Giladi, A., Wagner, L.K., Li, H., Dörr, D., Medaglia, C., Paul, F., Shemer, A., Jung, S., Yona, S., Mack, M., Leutz, A., Amit, I. and Mildner, A.
Nature Immunology 21 (5): 525-534. May 2020

2019

PRISMA: Protein Interaction Screen on Peptide Matrix reveals interaction footprints and modifications- dependent interactome of intrinsically disordered C/EBPb.
Dittmar, G., Perez Hernandez, D., Kowenz-Leutz, E., Kirchner, M., Kahlert, G., Wesolowski, R., Baum, K., Knoblich, M., Hofstätter, M., Muller, A., Wolf, J., Reimer, U. and Leutz, A.
iScience 13 : 351-370. 29 March 2019

Mapping the lung.
Mildner, A. and Yona, S.
Science 363 (6432): 1154-1155. 15 March 2019

A C/EBPα-Wnt connection in gut homeostasis and carcinogenesis.
Heuberger, J., Hill, U., Förster, S., Zimmermann, K., Malchin, V., Kühl, A.A., Stein, U., Vieth, M., Birchmeier, W. and Leutz, A.
Life Science Alliance 2 (1): e201800173. February 2019

2018

Good things come in threes.
Yona, S. and Mildner, A.
Science Immunology 3 (30): eaav5545. 7 December 2018

Developmental and functional heterogeneity of monocytes.
Guilliams, M., Mildner, A. and Yona, S.
Immunity 49 (4): 595-613. 16 October 2018

The C/EBPβ LIP isoform rescues loss of C/EBPβ function in the mouse.
Bégay, V., Baumeier, C., Zimmermann, K., Heuser, A. and Leutz, A.
Scientific Reports 8 (1): 8417. 30 May 2018

Loss-of-function uORF mutations in human malignancies.
Schulz, J., Mah, N., Neuenschwander, M., Kischka, T., Ratei, R., Schlag, P.M., Castaños-Vélez, E., Fichtner, I., Tunn, P.U., Denkert, C., Klaas, O., Berdel, W.E., von Kries, J.P., Makalowski, W., Andrade-Navarro, M.A., Leutz, A. and Wethmar, K.
Scientific Reports 8 (1): 2395. 5 February 2018

2017

SIRT1 regulates macrophage self-renewal.
Imperatore, F., Maurizio, J., Vargas Aguilar, S., Busch, C.J., Favret, J., Kowenz-Leutz, E., Cathou, W., Gentek, R., Perrin, P., Leutz, A., Berruyer, C. and Sieweke, M.H.
EMBO Journal 36 (16): 2353-2372. 15 August 2017

DNA base flipping analytical pipeline.
Zhang, P., Hastert, F.D., Ludwig, A.K., Breitwieser, K., Hofstätter, M. and Cardoso, M.C.
Biology Methods & Protocols 2 (1): bpx010. 11 August 2017

Genomic characterization of murine monocytes reveals C/EBPβ transcription factor dependence of Ly6C(-) cells.
Mildner, A., Schönheit, J., Giladi, A., David, E., Lara-Astiaso, D., Lorenzo-Vivas, E., Paul, F., Chappell-Maor, L., Priller, J., Leutz, A., Amit, I. and Jung, S.
Immunity 46 (5): 849-862. 16 May 2017

Ghosts in the shell: identification of microglia in the human central nervous system by P2Y12 receptor.
Mildner, A.
Neural Regeneration Research 12 (4): 570-571. April 2017

C/EBP-induced transdifferentiation reveals granulocyte-macrophage precursor-like plasticity of B cells.
Cirovic, B., Schönheit, J., Kowenz-Leutz, E., Ivanovska, J., Klement, C., Pronina, N., Bégay, V. and Leutz, A.
Stem Cell Reports 14 (8): 346-359. 14 February 2017

2016

C/EBPβ regulates homeostatic and oncogenic gastric cell proliferation.
Regalo, G., Förster, S., Resende, C., Bauer, B., Fleige, B., Kemmner, W., Schlag, P.M., Meyer, T.F., Machado, J.C. and Leutz, A.
Journal of Molecular Medicine 94 (12): 1385-1395. December 2016

Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients.
Szasz, A.M., Lanczky, A., Nagy, A., Foerster, S., Hark, K., Green, J.E., Boussioutas, A., Busuttil, R., Szabo, A. and Gyorffy, B.
Oncotarget 7 (31): 49322-49333. 2 August 2016

Functional interaction of CCAAT/enhancer-binding-protein-α basic region mutants with E2F transcription factors and DNA.
Kowenz-Leutz, E., Schuetz, A., Liu, Q., Knoblich, M., Heinemann, U. and Leutz, A.
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1859 (7): 841-847. July 2016

CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells.
Drachsler, M., Kleber, S., Mateos, A., Volk, K., Mohr, N., Chen, S., Cirovic, B., Tuettenberg, J., Gieffers, C., Sykora, J., Wirtz, C.R., Mueller, W., Synowitz, M. and Martin-Villalba, A.
Cell Death & Disease 7 : e2209. 28 April 2016

Comprehensive translational control of tyrosine kinase expression by upstream open reading frames.
Wethmar, K., Schulz, J., Muro, E.M., Talyan, S., Andrade-Navarro, M.A. and Leutz, A.
Oncogene 35 (13): 1736-1742. 31 March 2016

Poly(ADP-ribosyl)ation of Methyl CpG binding domain protein 2 regulates chromatin structure.
Becker, A., Zhang, P., Allmann, L., Meilinger, D., Bertulat, B., Eck, D., Hofstaetter, M., Bartolomei, G., Hottiger, M.O., Schreiber, V., Leonhardt, H. and Cardoso, M.C.
Journal of Biological Chemistry 291 (10): 4873-4881. 4 March 2016

2015

Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice.
Zidek, L.M., Ackermann, T., Hartleben, G., Eichwald, S., Kortman, G., Kiehntopf, M., Leutz, A., Sonenberg, N., Wang, Z.Q., von Maltzahn, J., Müller, C. and Calkhoven, C.F.
EMBO Reports 16 (08): 1022-1036. August 2015

Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor.
Grajales-Reyes, G.E., Iwata, A., Albring, J., Wu, X., Tussiwand, R., Kc, W., Kretzer, N.M., Briseno, C.G., Durai, V., Bagadia, P., Haldar, M., Schoenheit, J., Rosenbauer, F., Murphy, T.L. and Murphy, K.M.
Nature Immunology 16 (7): 708-717. July 2015

Chromatin dynamics during differentiation of myeloid cells.
Schönheit, J., Leutz, A. and Rosenbauer, F.
Journal of Molecular Biology 427 (3): 670-687. 13 February 2015

Deregulation of the endogenous C/EBPβ LIP isoform predisposes to tumorigenesis.
Bégay, V., Smink, J.J., Loddenkemper, C., Zimmermann, K., Rudolph, C., Scheller, M., Steinemann, D., Leser, U., Schlegelberger, B., Stein, H. and Leutz, A.
Journal of Molecular Medicine 93 (1): 39-49. January 2015

2014

Modes of TAL effector-mediated repression.
Werner, J. and Gossen, M.
Nucleic Acids Research 42 (21): 13061-13073. 1 December 2014

A high content screening assay for evaluation of biomaterial-mediated cell fusion processes.
Rijckaert, B., Neffe, A.T., Roch, T., Gebauer, T., Pierce, B.F., Görs, J., Smink, J.J., Gossen, M., Lendlein, A. and Leutz, A.
Macromolecular Symposia 346 (1): 91-99. December 2014

The regulatory potential of upstream open reading frames in eukaryotic gene expression.
Wethmar, K.
Wiley Interdisciplinary Reviews: RNA 5 (6): 765-768. November 2014

Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ.
Rehm, A., Gätjen, M., Gerlach, K., Scholz, F., Mensen, A., Gloger, M., Heinig, K., Lamprecht, B., Mathas, S., Bégay, V., Leutz, A., Lipp, M., Dörken, B. and Höpken, U.E.
Nature Communications 5 : 5057. 30 September 2014

Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model.
Schwarzer, R., Nickel, N., Godau, J., Willie, B.M., Duda, G.N., Schwarzer, R., Cirovic, B., Leutz, A., Manz, R., Bogen, B., Dörken, B. and Jundt, F.
Blood Cancer Journal 4 : e217. 13 June 2014

uORFdb - a comprehensive literature database on eukaryotic uORF biology.
Wethmar, K., Barbosa-Silva, A., Andrade-Navarro, M.A. and Leutz, A.
Nucleic Acids Research 42 (1): D60-D67. 1 January 2014

2013

Cross talk between Wnt/β-catenin and Irf8 in leukemia progression and drug resistance.
Scheller, M., Schönheit, J., Zimmermann, K., Leser, U., Rosenbauer, F. and Leutz, A.
Journal of Experimental Medicine 210 (11): 2239-2256. 21 October 2013

Hacking cell differentiation: transcriptional rerouting in reprogramming, lineage infidelity and metaplasia.
Regalo, G. and Leutz, A.
EMBO Molecular Medicine 5 (8): 1154-1164. August 2013

Lymphoid to myeloid cell trans-differentiation is determined by C/EBPβ structure and post-translational modifications.
Stoilova, B., Kowenz-Leutz, E., Scheller, M. and Leutz, A.
PLoS ONE 8 (6): e65169. 5 June 2013

Stable conditional expression and effect of C/EBPβ-LIP in adipocytes using the pSLIK system.
Esteves, C.L., Kelly, V., Bégay, V., Lillico, S.G., Leutz, A., Seckl, J.R. and Chapman, K.
Journal of Molecular Endocrinology 51 (1): 91-98. 4 June 2013

PU.1 level-directed chromatin structure remodeling at the Irf8 gene drives dendritic cell commitment.
Schönheit, J., Kuhl, C., Gebhardt, M.L., Klett, F.F., Riemke, P., Scheller, M., Huang, G., Naumann, R., Leutz, A., Stocking, C., Priller, J., Andrade-Navarro, M.A. and Rosenbauer, F.
Cell Reports 3 (5): 1617-1628. 30 May 2013

Tet-Transgenic Rodents: a comprehensive, up-to date database.
Schoenig, K., Freundlieb, S. and Gossen, M.
Transgenic Research 22 (2): 251-254. April 2013

Loss of methylation at the IFNG promoter and CNS-1 associates with the development of functional IFN-γ memory in human CD4(+) T lymphocytes.
Dong, J., Chang, H.D., Ivascu, C., Qian, Y., Rezai, S., Okhrimenko, A., Cosmi, L., Maggi, L., Eckhardt, F., Wu, P., Sieper, J., Alexander, T., Annunziato, F., Gossen, M., Li, J., Radbruch, A. and Thiel, A.
European Journal of Immunology 43 (3): 793-804. March 2013

Direct homo- and hetero-interactions of MeCP2 and MBD2.
Becker, A., Allmann, L., Hofstätter, M., Casa, V., Weber, P., Lehmkuhl, A., Herce, H.D. and Cardoso, M.C.
PLoS ONE 8 (1): e53730. 15 January 2013

2012

Regulation of adipocyte 11beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) by CCAAT/enhancer-binding protein (C/EBP) beta isoforms, LIP and LAP.
Esteves, C.L., Kelly, V., Bégay, V., Man, T.Y., Morton, N.M., Leutz, A., Seckl, J.R. and Chapman, K.E.
PLoS ONE 7 (5): e37953. 25 May 2012

Instruction of mesenchymal cell fate by the transcription factor C/EBPbeta.
Smink, J.J. and Leutz, A.
Gene 497 (1): 10-17. 10 April 2012

A TORway to osteolytic disease.
Smink, J.J. and Leutz, A.
Cell Cycle 11 (4): 637-638. 15 February 2012

Tal1 regulates osteoclast differentiation through suppression of the master regulator of cell fusion DC-STAMP.
Courtial, N., Smink, J.J., Kuvardina, O.N., Leutz, A., Goethert, J.R. and Lausen, J.
FASEB Journal 26 (2): 523-532. February 2012

Rapamycin inhibits osteoclast formation in giant cell tumor of bone through the C/EBPβ - MafB axis.
Smink, J.J., Tunn, P.U. and Leutz, A.
Journal of Molecular Medicine 90 (1): 25-30. January 2012

2011

Streamlining homogeneous glycoprotein production for biophysical and structural applications by targeted cell line development.
Wilke, S., Groebe, L., Maffenbeier, V., Jaeger, V., Gossen, M., Josewski, J., Duda, A., Polle, L., Owens, R.J., Wirth, D., Heinz, D.W., van den Heuvel, J. and Buessow, K.
PLoS ONE 6 (12): e27829. December 2011

Different roles of the human Orc6 protein in the replication initiation process.
Thomae, A.W., Baltin, J., Pich, D., Deutsch, M.J., Ravasz, M., Zeller, K., Gossen, M., Hammerschmidt, W. and Schepers, A.
Cellular and Molecular Life Sciences 68 (22): 3741-3756. November 2011

Eukaryotic initiation factor 2α phosphorylation is required for B cell maturation and function in mice.
Mielke, N., Schwarzer, R., Calkhoven, C.F., Kaufman, R., Doerken, B., Leutz, A. and Jundt, F.
Haematologica 96 (9): 1261-1268. September 2011

Development of a BAC vector for integration-independent and tight regulation of transgenes in rodents via the Tet system.
Schoenig, K., Kentner, D., Gossen, M., Baldinger, T., Miao, J., Welzel, K., Vente, A., Bartsch, D. and Bujard, H.
Transgenic Research 20 (3): 709-720. June 2011

A differential proteome screening system for post-translational modification-dependent transcription factor interactions.
Pless, O., Kowenz-Leutz, E., Dittmar, G. and Leutz, A.
Nature Protocols 6 (3): 359-364. February 2011

Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs.
Leutz, A., Pless, O., Lappe, M., Dittmar, G. and Kowenz-Leutz, E.
Transcription 2 (1): 3-8. January 2011

2010

Improved Tet-responsive promoters with minimized background expression.
Loew, R., Heinz, N., Hampf, M., Bujard, H. and Gossen, M.
BMC Biotechnology 10 (1): 81. 24 November 2010

I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development.
Orinska, Z., Foeger, N., Huber, M., Marschall, J., Mirghomizadeh, F., Du, X., Scheller, M., Rosenstiel, P., Goldmann, T., Bollinger, A., Beutler, B.A. and Bulfone-Paus, S.
Blood 116 (15): 2665-2675. 14 October 2010

Upstream open reading frames: molecular switches in (patho)physiology.
Wethmar, K., Smink, J.J. and Leutz, A.
BioEssays 32 (10): 885-893. October 2010

Glycoprotein production for structure analysis with stable, glycosylation mutant CHO cell lines established by fluorescence-activated cell sorting.
Wilke, S., Krausze, J., Gossen, M., Groebe, L., Jaeger, V., Gherardi, E., van den Heuvel, J. and Buessow, K.
Protein Science 19 (6): 1264-1271. June 2010

Repression of transcriptional activity of C/EBPα by E2F-DP complexes.
Zaragoza, K., Bégay, V., Schuetz, A., Heinemann, U. and Leutz, A.
Molecular and Cellular Biology 30 (9): 2293-2304. May 2010

Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code.
Kowenz-Leutz, E., Pless, O., Dittmar, G., Knoblich, M. and Leutz, A.
EMBO Journal 29 (6): 1105-1115. 17 March 2010

Rapamycin and the transcription factor C/EBPbeta as a switch in osteoclast differentiation: implications for lytic bone diseases.
Smink, J.J. and Leutz, A.
Journal of Molecular Medicine 88 (3): 227-233. March 2010

Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1.
Lausen, J., Pless, O., Leonard, F., Kuvardina-Bolling, O.N., Koch, B. and Leutz, A.
Journal of Biological Chemistry 285 (8): 5338-5346. 19 February 2010

C/EBPbetaDeltauORF mice--a genetic model for uORF-mediated translational control in mammals.
Wethmar, K., Bégay, V., Smink, J.J., Zaragoza, K., Wiesenthal, V., Doerken, B., Calkhoven, C.F. and Leutz, A.
Genes & Development 24 (1): 15-20. 1 January 2010

2009

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.
Broeske, A.M., Vockentanz, L., Kharazi, S., Huska, M.R., Mancini, E., Scheller, M., Kuhl, C., Enns, A., Prinz, M., Jaenisch, R., Nerlov, C., Leutz, A., Andrade-Navarro, M.A., Jacobsen, S.E. and Rosenbauer, F.
Nature Genetics 41 (11): 1207-1215. November 2009

Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB.
Smink, J.J., Bégay, V., Schoenmaker, T., Sterneck, E., de Vries, T.J. and Leutz, A.
EMBO Journal 28 (12): 1769-1781. 17 June 2009

2008

G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta.
Pless, O., Kowenz-Leutz, E., Knoblich, M., Lausen, J., Beyerman, M., Walsh, M.J. and Leutz, A.
Journal of Biological Chemistry 283 (39): 26357-26363. 26 September 2008

Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth.
Simmons, D.G., Natale, D.R., Begay, V., Hughes, M., Leutz, A. and Cross, J.C.
Development 135 (12): 2083-2091. June 2008

Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin.
Jeannet, G., Scheller, M., Scarpellino, L., Duboux, S., Gardiol, N., Back, J., Kuttler, F., Malanchi, I., Birchmeier, W., Leutz, A., Huelsken, J. and Held, W.
Blood 111 (1): 142-149. 1 January 2008

2007

The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells.
Chen, Y., Xu, H., Liu, J., Zhang, C., Leutz, A. and Mo, X.
Biochemical and Biophysical Research Communications 360 (2): 433-436. 24 August 2007

Tissue-specific transcription factor HNF4alpha inhibits cell proliferation and induces apoptosis in the pancreatic INS-1 beta-cell line.
Erdmann, S., Senkel, S., Arndt, T., Lucas, B., Lausen, J., Klein-Hitpass, L., Ryffel, G.U. and Thomas, H.
Biological Chemistry 388 (1): 91-106. January 2007

2006

Analysis of translation initiation using a translation control reporter system.
Wiesenthal, V., Leutz, A. and Calkhoven, C.F.
Nature Protocols 1 (3): 1531-1537. 9 November 2006

Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation.
Scheller, M., Huelsken, J., Rosenbauer, F., Taketo, M.M., Birchmeier, W., Tenen, D.G. and Leutz, A.
Nature Immunology 7 (10): 1037-1047. October 2006

ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO.
Lausen, J., Liu, S., Fliegauf, M., Luebbert, M. and Werner, M.H.
Oncogene 25 (9): 1349-1357. 2 March 2006

A translation control reporter system (TCRS) for the analysis of translationally controlled processes in the vertebrate cell.
Wiesenthal, V., Leutz, A. and Calkhoven, C.F.
Nucleic Acids Research 34 (3): e23. 10 February 2006

Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1.
Rosenbauer, F., Owens, B.M., Yu, L., Tumang, J.R., Steidl, U., Kutok, J.L., Clayton, L.K., Wagner, K., Scheller, M., Iwasaki, H., Liu, C., Hackanson, B., Akashi, K., Leutz, A., Rothstein, T.L., Plass, C. and Tenen, D.G.
Nature Genetics 38 (1): 27-37. January 2006

2005

Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain.
Mo, X., Kowenz-Leutz, E., Laumonnier, Y., Xu, H. and Leutz, A.
Genes & Development 19 (20): 2447-2457. 29 September 2005

HNF4alpha reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma.
Lucas, B., Grigo, K., Erdmann, S., Lausen, J., Klein-Hitpass, L. and Ryffel, G.U.
Oncogene 24 (42): 6418-6431. 22 September 2005

A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein beta and NF-kappaB activity in Hodgkin and anaplastic large cell lymphomas.
Jundt, F., Raetzel, N., Mueller, C., Calkhoven, C.F., Kley, K., Mathas, S., Lietz, A., Leutz, A. and Doerken, B.
Blood 106 : 1801-1807. 1 January 2005

2004

Essential requirement of CCAAT/enhancer binding proteins in embryogenesis.
Bégay, V., Smink, J. and Leutz, A.
Molecular and Cellular Biology 24 (22): 9744-9751. 1 November 2004

Molecular genetics of hematopoiesis & leukemogenesis.
Leutz, A.
Zellbiologie Aktuell 30 (3): 16-18. May 2004

Ras induces mediator complex exchange on C/EBPβ.
Mo, X.M., Kowenz-Leutz, E., Xu, H. and Leutz, A.
Molecular Cell 13 (2): 241-250. 30 January 2004

A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.
Bourbon, H.M., Aguilera, A., Ansari, A.Z., Asturias, F.J., Berk, A.J., Bjorklund, S., Blackwell, T.K., Borggrefe, T., Carey, M., Carlson, M., Conaway, J.W., Conaway, R.C., Emmons, S.W., Fondell, J.D., Freedman, L.P., Fukasawa, T., Gustafsson, C.M., Han, M., He, X., Herman, P.K., Hinnebusch, A.G., Holmberg, S., Holstege, F.C., Jaehning, J.A., Kim, Y.J., Kuras, L., Leutz, A., Lis, J.T., Meisterernest, M., Naar, A.M., Nasmyth, K., Parvin, J.D., Ptashne, M., Reinberg, D., Ronne, H., Sadowski, I., Sakurai, H., Sipiczki, M., Sternberg, P.W., Stillman, D.J., Strich, R., Struhl, K., Svejstrup, J.Q., Tuck, S., Winston, F., Roeder, R.G. and Kornberg, R.D.
Molecular Cell 14 (5): 553-557. 1 January 2004

Myb partnerships.
Mo, X., Kowenz-Leutz, E. and Leutz, A.
In: Myb Transcription Factors: Their Role in Growth, Differentiation and Disease. Proteins and Cell Regulation . Kluwer, Dordrecht, 239-256. ISBN 978-1-4020-2779-6 1 January 2004

TNAP, a novel repressor of NF-kappaB-inducing kinase, suppresses NF-kappaB activation.
Hu, W.H., Mo, X.M., Walters, W.M., Brambilla, R. and Bethea, J.R.
Journal of Biological Chemistry 279 (34): 35975-35983. 1 January 2004

The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest.
Mueller, C., Calkhoven, C.F., Sha, X.J. and Leutz, A.
Journal of Biological Chemistry 279 (8): 7353-7358. 1 January 2004

2003

Translational control of SCL-isoform expression in hematopoietic lineage choice.
Calkhoven, C.F., Mueller, C., Martin, R., Krosl, G., Hoang, T. and Leutz, A.
Genes & Development 17 (8): 959-964. 15 April 2003

Phosphorylation-dependent down-regulation of c-Myb DNA binding is abrogated by a point mutation in the v-myb oncogene.
Andersson, K.B., Kowenz-Leutz, E., Brendeford, E.M., Tygsett, A.H.H., Leutz, A. and Gabrielsen, O.S.
Journal of Biological Chemistry 278 (6): 3816-3824. 7 February 2003

Distinct changes in gene expression induced by A-Myb, B-Myb and c-Myb proteins.
Rushton, J.J., Davis, L.M., Lei, W.L., Mo, X.M., Leutz, A. and Ness, S.A.
Oncogene 22 (2): 308-313. 16 January 2003

2002

Translational control of gene expression and disease.
Calkhoven, C.F., Mueller, C. and Leutz, A.
Trends in Molecular Medicine 8 (12): 577-583. 1 December 2002

Vektorsystem zum Screening von Wirkstoffen [Vector system used in screening active substances].
Calkhoven, C.F. and Leutz, A.
DE10104952A1 ; EP1360331 ; WO0263036. 8 August 2002

The LIM domain protein Lmo2 binds to AF6, a translocation partner of the MLL oncogene.
Bégay-Müller, V., Ansieau, S. and Leutz, A.
FEBS Letters 521 (1-3): 36-38. 19 June 2002

The conserved Mynd domain of BS69 binds cellular and oncoviral proteins through a common PXLXP motif.
Ansieau, S. and Leutz, A.
Journal of Biological Chemistry 277 (7): 4906-4910. 1 January 2002

2001

Activation of the Notch-regulated transcription factor CBF1/RBP-J kappa through the 13SE1A oncoprotein.
Ansieau, S., Strobl, L.J. and Leutz, A.
Genes & Development 15 (4): 380-385. 1 January 2001

Adenovirus-mediated gene transfer as a tool to study angiogenesis in the chick embryo.
Hautmann, M.B., Wilting, J., Haller, H. and Leutz, A.
Development Genes and Evolution 211 (12): 611-616. 1 January 2001

Chromatin remodeling in development and differentiation.
Mueller, C. and Leutz, A.
Current Opinion in Genetics & Development 11 (2): 167-174. 1 January 2001

Cooperation between C/EBP alphaTBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation.
Pedersen, T.A., Kowenz-Leutz, E., Leutz, A. and Nerlov, C.
Genes & Development 15 (21): 3208-3216. 1 January 2001

Tumorigenic N-terminal deletions of c-Myb modulate DNA binding, transactivation, and cooperativity with C/EBP.
Oelgeschlager, M., Kowenz-Leutz, E., Schreek, S., Leutz, A. and Luescher, B.
Oncogene 20 (50): 7420-7424. 1 January 2001

2000

Translational control of C/EBP alpha and C/EBP beta isoform expression.
Calkhoven, C.F., Mueller, C. and Leutz, A.
Genes & Development 14 (15): 1920-1932. 1 August 2000

Mittel zur Inhibition der Gewebsneubildung.
Praus, M., Leutz, A. and Gulba, D.C.
DE19859780A1. 29 June 2000

1999

A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes.
Kowenz-Leutz, E. and Leutz, A.
Molecular Cell 4 (5): 735-743. November 1999

Chlamydia pneumoniae infection of vascular smooth muscle and endothelial cells activates NF-kappaB and induces tissue factor and PAI-1 expression - A potential link to accelerated arteriosclerosis.
Dechend, R., Maass, M., Gieffers, J., Dietz, R., Scheidereit, C., Leutz, A. and Gulba, D.C.
Circulation 100 : 1369-1373. 28 September 1999

Separation of C/EBP alpha-mediated proliferation arrest and differentiation pathways.
Mueller, C., Alunni-Fabroni, M., Kowenz-Leutz, E., Mo, X.M., Tommasino, M. and Leutz, A.
Proceedings of the National Academy of Sciences of the United States of America 96 : 7276-7281. 22 June 1999

The Bcl-3 oncoprotein acts as a bridging factor between NF-kappa B/Rel and nuclear co-regulators.
Dechend, R., Hirano, F., Lehmann, K., Heissmeyer, V., Ansieau, S., Wulczyn, F.G., Scheidereit, C. and Leutz, A.
Oncogene 18 : 3316-3323. 3 June 1999

1998

Distinct C/EBP functions are required for eosinophil lineage commitment and maturation.
Nerlov, C., McNagny, K.M., Doederlein, G., Kowenz-Leutz, E. and Graf, T.
Genes & Development 12 (15): 2413-2423. 1 August 1998

Expression of the homeobox gene GBX2 during chicken development.
Niss, K. and Leutz, A.
Mechanisms of Development 76 (1-2): 151-155. August 1998

1997

Cloning of two novel human importin alpha subunits and analysis of the expression pattern of the importin-alpha protein family.
Koehler, M., Ansieau, S., Prehn, S., Leutz, A., Haller, H. and Hartmann, E.
FEBS Letters 417 (1): 104-108. 3 November 1997

B-Myb, a repressed trans-activating protein.
Ansieau, S., Kowenz-Leutz, E., Dechend, R. and Leutz, A.
Journal of Molecular Medicine 75 (11-12): 815-819. November 1997

Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein.
Dhordain, P., Albagli, O., Lin, R.J., Ansieau, S., Quief, S., Leutz, A., Kerckaert, J.P., Evans, R.M. and Leprince, D.
Proceedings of the National Academy of Sciences of the United States of America 94 (20): 10762-10767. 30 September 1997

The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation.
Kowenz-Leutz, E., Herr, P., Niss, K. and Leutz, A.
Cell 91 : 185-195. 1 January 1997

1996

Regulation of C/EBPbeta /NF-M activity by kinase oncogenes.
Twamley-Stein, G., Kowenz-Leutz, E., Ansieau, S. and Leutz, A.
Current Topics in Microbiology and Immunology 211 : 129-136. 1 January 1996

1995

The BTB/POZ domain targets the LAZ3/BCL6 oncoprotein to nuclear dots and mediates homomerisation in vivo.
Dhordain, P., Albagli, O., Ansieau, S., Koken, M., Deweindt, C., Quief, S., Lantoine, D., Leutz, A., Kerckaert, J.P. and Leprince, D.
Oncogene 11 (12): 2689-2697. 21 December 1995

Gene regulation by NF-M and Myb during differentiation and leukemic transformation.
Kowenz-Leutz, E., Ansieau, S., Twamley-Stein, G., Ness, S.A. and Leutz, A.
Immunobiology 193 : 356-362. 1 January 1995

NF-M (chicken C/EBP beta) induces eosinophilic differentiation and apoptosis in a hematopoietic progenitor cell line.
Mueller, C., Kowenz-Leutz, E., Grieser-Ade, S., Graf, T. and Leutz, A.
EMBO Journal 14 (24): 6127-6135. 1 January 1995

1994

Novel mechanism of C/EBPbeta (NF-M) transcriptional control: activation through derepression.
Kowenz-Leutz, E., Twamley, G., Ansieau, S. and Leutz, A.
Genes & Development 8 (22): 2781-2791. 15 November 1994

C/EBP beta regulation of the tumor necrosis factor alpha gene.
Pope, R.M., Leutz, A. and Ness, S.A.
Journal of Clinical Investigation 94 (4): 1449-1455. October 1994

Essential role of c-myc in ara-C-induced differentiation of human erythroleukemia cells.
Baker, S.J., Pawlita, M., Leutz, A. and Hoelzer, D.
Leukemia 8 (8): 1309-1317. August 1994

Recombinant murine erythropoietin receptor expressed in avian erythroid progenitors mediates terminal erythroid differentiation in vitro.
Steinlein, P., Deiner, E., Leutz, A. and Beug, H.
Growth Factors 10 (1): 1-16. 1994

1993

Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types.
Ness, S.A., Kowenz-Leutz, E., Casini, T., Graf, T. and Leutz, A.
Genes & Development 7 (5): 749-759. May 1993

The NF-M transcription factor is related to C/EBP beta and plays a role in signal transduction, differentiation and leukemogenesis of avian myelomonocytic cells.
Katz, S., Kowenz-Leutz, E., Mueller, C., Meese, K., Ness, S.A. and Leutz, A.
EMBO Journal 12 (4): 1321-1332. April 1993

1992

Constitutive monocyte-restricted activity of NF-M, a nuclear factor that binds to a C/EBP motif.
Haas, J.G., Stroebel, M., Leutz, A., Wendelgass, P., Mueller, C., Sterneck, E., Riethmueller, G. and Ziegler-Heitbrock, H.W.
Journal of Immunology 149 (1): 237-243. 1 July 1992

Structure of the chicken myelomonocytic growth factor gene and specific activation of its promoter in avian myelomonocytic cells by protein kinases.
Sterneck, E., Blattner, C., Graf, T. and Leutz, A.
Molecular and Cellular Biology 12 (4): 1728-1735. April 1992

Autocrine growth induced by kinase type oncogenes in myeloid cells requires AP-1 and NF-M, a myeloid specific, C/EBP-like factor.
Sterneck, E., Mueller, C., Katz, S. and Leutz, A.
EMBO Journal 11 (1): 115-126. January 1992

This list was generated on Mon Dec 2 11:02:13 2024 UTC.
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