Browse by Research Team

Annals of the Rheumatic Diseases

CSF2-dependent monocyte education in the pathogenesis of ANCA-induced glomerulonephritis.
Rousselle, A. and Sonnemann, J. and Amann, K. and Mildner, A. and Lodka, D. and Kling, L. and Bieringer, M. and Schneider, U. and Leutz, A. and Enghard, P. and Kettritz, R. and Schreiber, A.
Annals of the Rheumatic Diseases 81 (8): 1162-1172. August 2022

BMC Biotechnology

Improved Tet-responsive promoters with minimized background expression.
Loew, R. and Heinz, N. and Hampf, M. and Bujard, H. and Gossen, M.
BMC Biotechnology 10 (1): 81. 24 November 2010

BioEssays

Upstream open reading frames: molecular switches in (patho)physiology.
Wethmar, K. and Smink, J.J. and Leutz, A.
BioEssays 32 (10): 885-893. October 2010

Biochemical and Biophysical Research Communications

The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells.
Chen, Y. and Xu, H. and Liu, J. and Zhang, C. and Leutz, A. and Mo, X.
Biochemical and Biophysical Research Communications 360 (2): 433-436. 24 August 2007

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Functional interaction of CCAAT/enhancer-binding-protein-α basic region mutants with E2F transcription factors and DNA.
Kowenz-Leutz, E. and Schuetz, A. and Liu, Q. and Knoblich, M. and Heinemann, U. and Leutz, A.
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1859 (7): 841-847. July 2016

Biological Chemistry

Tissue-specific transcription factor HNF4alpha inhibits cell proliferation and induces apoptosis in the pancreatic INS-1 beta-cell line.
Erdmann, S. and Senkel, S. and Arndt, T. and Lucas, B. and Lausen, J. and Klein-Hitpass, L. and Ryffel, G.U. and Thomas, H.
Biological Chemistry 388 (1): 91-106. January 2007

Biology Methods & Protocols

DNA base flipping analytical pipeline.
Zhang, P. and Hastert, F.D. and Ludwig, A.K. and Breitwieser, K. and Hofstätter, M. and Cardoso, M.C.
Biology Methods & Protocols 2 (1): bpx010. 11 August 2017

Blood

I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development.
Orinska, Z. and Foeger, N. and Huber, M. and Marschall, J. and Mirghomizadeh, F. and Du, X. and Scheller, M. and Rosenstiel, P. and Goldmann, T. and Bollinger, A. and Beutler, B.A. and Bulfone-Paus, S.
Blood 116 (15): 2665-2675. 14 October 2010

Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin.
Jeannet, G. and Scheller, M. and Scarpellino, L. and Duboux, S. and Gardiol, N. and Back, J. and Kuttler, F. and Malanchi, I. and Birchmeier, W. and Leutz, A. and Huelsken, J. and Held, W.
Blood 111 (1): 142-149. 1 January 2008

A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein beta and NF-kappaB activity in Hodgkin and anaplastic large cell lymphomas.
Jundt, F. and Raetzel, N. and Mueller, C. and Calkhoven, C.F. and Kley, K. and Mathas, S. and Lietz, A. and Leutz, A. and Doerken, B.
Blood 106 : 1801-1807. 1 January 2005

Blood Cancer Journal

Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model.
Schwarzer, R. and Nickel, N. and Godau, J. and Willie, B.M. and Duda, G.N. and Schwarzer, R. and Cirovic, B. and Leutz, A. and Manz, R. and Bogen, B. and Dörken, B. and Jundt, F.
Blood Cancer Journal 4 : e217. 13 June 2014

Cell

The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation.
Kowenz-Leutz, E. and Herr, P. and Niss, K. and Leutz, A.
Cell 91 : 185-195. 1 January 1997

Cell Cycle

A TORway to osteolytic disease.
Smink, J.J. and Leutz, A.
Cell Cycle 11 (4): 637-638. 15 February 2012

Cell Death & Disease

CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells.
Drachsler, M. and Kleber, S. and Mateos, A. and Volk, K. and Mohr, N. and Chen, S. and Cirovic, B. and Tuettenberg, J. and Gieffers, C. and Sykora, J. and Wirtz, C.R. and Mueller, W. and Synowitz, M. and Martin-Villalba, A.
Cell Death & Disease 7 : e2209. 28 April 2016

Cell Reports

PU.1 level-directed chromatin structure remodeling at the Irf8 gene drives dendritic cell commitment.
Schönheit, J. and Kuhl, C. and Gebhardt, M.L. and Klett, F.F. and Riemke, P. and Scheller, M. and Huang, G. and Naumann, R. and Leutz, A. and Stocking, C. and Priller, J. and Andrade-Navarro, M.A. and Rosenbauer, F.
Cell Reports 3 (5): 1617-1628. 30 May 2013

Cell Stem Cell

C/EBPβ-dependent epigenetic memory induces trained immunity in hematopoietic stem cells.
de Laval, B. and Maurizio, J. and Kandalla, P.K. and Brisou, G. and Simonnet, L. and Huber, C. and Gimenez, G. and Matcovitch-Natan, O. and Reinhardt, S. and David, E. and Mildner, A. and Leutz, A. and Nadel, B. and Bordi, C. and Amit, I. and Sarrazin, S. and Sieweke, M.H.
Cell Stem Cell 26 (5): 657-674. May 2020

Cellular and Molecular Life Sciences

Different roles of the human Orc6 protein in the replication initiation process.
Thomae, A.W. and Baltin, J. and Pich, D. and Deutsch, M.J. and Ravasz, M. and Zeller, K. and Gossen, M. and Hammerschmidt, W. and Schepers, A.
Cellular and Molecular Life Sciences 68 (22): 3741-3756. November 2011

Circulation

Chlamydia pneumoniae infection of vascular smooth muscle and endothelial cells activates NF-kappaB and induces tissue factor and PAI-1 expression - A potential link to accelerated arteriosclerosis.
Dechend, R. and Maass, M. and Gieffers, J. and Dietz, R. and Scheidereit, C. and Leutz, A. and Gulba, D.C.
Circulation 100 : 1369-1373. 28 September 1999

Current Opinion in Genetics & Development

Chromatin remodeling in development and differentiation.
Mueller, C. and Leutz, A.
Current Opinion in Genetics & Development 11 (2): 167-174. 1 January 2001

Current Topics in Microbiology and Immunology

Regulation of C/EBPbeta /NF-M activity by kinase oncogenes.
Twamley-Stein, G. and Kowenz-Leutz, E. and Ansieau, S. and Leutz, A.
Current Topics in Microbiology and Immunology 211 : 129-136. 1 January 1996

Development

Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth.
Simmons, D.G. and Natale, D.R. and Begay, V. and Hughes, M. and Leutz, A. and Cross, J.C.
Development 135 (12): 2083-2091. June 2008

Development Genes and Evolution

Adenovirus-mediated gene transfer as a tool to study angiogenesis in the chick embryo.
Hautmann, M.B. and Wilting, J. and Haller, H. and Leutz, A.
Development Genes and Evolution 211 (12): 611-616. 1 January 2001

EMBO Journal

SIRT1 regulates macrophage self-renewal.
Imperatore, F. and Maurizio, J. and Vargas Aguilar, S. and Busch, C.J. and Favret, J. and Kowenz-Leutz, E. and Cathou, W. and Gentek, R. and Perrin, P. and Leutz, A. and Berruyer, C. and Sieweke, M.H.
EMBO Journal 36 (16): 2353-2372. 15 August 2017

Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code.
Kowenz-Leutz, E. and Pless, O. and Dittmar, G. and Knoblich, M. and Leutz, A.
EMBO Journal 29 (6): 1105-1115. 17 March 2010

Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB.
Smink, J.J. and Bégay, V. and Schoenmaker, T. and Sterneck, E. and de Vries, T.J. and Leutz, A.
EMBO Journal 28 (12): 1769-1781. 17 June 2009

NF-M (chicken C/EBP beta) induces eosinophilic differentiation and apoptosis in a hematopoietic progenitor cell line.
Mueller, C. and Kowenz-Leutz, E. and Grieser-Ade, S. and Graf, T. and Leutz, A.
EMBO Journal 14 (24): 6127-6135. 1 January 1995

The NF-M transcription factor is related to C/EBP beta and plays a role in signal transduction, differentiation and leukemogenesis of avian myelomonocytic cells.
Katz, S. and Kowenz-Leutz, E. and Mueller, C. and Meese, K. and Ness, S.A. and Leutz, A.
EMBO Journal 12 (4): 1321-1332. April 1993

Autocrine growth induced by kinase type oncogenes in myeloid cells requires AP-1 and NF-M, a myeloid specific, C/EBP-like factor.
Sterneck, E. and Mueller, C. and Katz, S. and Leutz, A.
EMBO Journal 11 (1): 115-126. January 1992

EMBO Molecular Medicine

Hacking cell differentiation: transcriptional rerouting in reprogramming, lineage infidelity and metaplasia.
Regalo, G. and Leutz, A.
EMBO Molecular Medicine 5 (8): 1154-1164. August 2013

EMBO Reports

Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice.
Zidek, L.M. and Ackermann, T. and Hartleben, G. and Eichwald, S. and Kortman, G. and Kiehntopf, M. and Leutz, A. and Sonenberg, N. and Wang, Z.Q. and von Maltzahn, J. and Müller, C. and Calkhoven, C.F.
EMBO Reports 16 (08): 1022-1036. August 2015

European Journal of Immunology

Loss of methylation at the IFNG promoter and CNS-1 associates with the development of functional IFN-γ memory in human CD4(+) T lymphocytes.
Dong, J. and Chang, H.D. and Ivascu, C. and Qian, Y. and Rezai, S. and Okhrimenko, A. and Cosmi, L. and Maggi, L. and Eckhardt, F. and Wu, P. and Sieper, J. and Alexander, T. and Annunziato, F. and Gossen, M. and Li, J. and Radbruch, A. and Thiel, A.
European Journal of Immunology 43 (3): 793-804. March 2013

FASEB Journal

Tal1 regulates osteoclast differentiation through suppression of the master regulator of cell fusion DC-STAMP.
Courtial, N. and Smink, J.J. and Kuvardina, O.N. and Leutz, A. and Goethert, J.R. and Lausen, J.
FASEB Journal 26 (2): 523-532. February 2012

FEBS Letters

The LIM domain protein Lmo2 binds to AF6, a translocation partner of the MLL oncogene.
Bégay-Müller, V. and Ansieau, S. and Leutz, A.
FEBS Letters 521 (1-3): 36-38. 19 June 2002

Cloning of two novel human importin alpha subunits and analysis of the expression pattern of the importin-alpha protein family.
Koehler, M. and Ansieau, S. and Prehn, S. and Leutz, A. and Haller, H. and Hartmann, E.
FEBS Letters 417 (1): 104-108. 3 November 1997

Frontiers in Immunology

Editorial: Monocyte heterogeneity and function.
Ginhoux, F. and Mildner, A. and Gautier, E.L. and Schlitzer, A. and Jakubzick, C. and Varol, C. and Bain, C. and Guermonprez, P.
Frontiers in Immunology 11 : 626725. 7 January 2021

Gene

Instruction of mesenchymal cell fate by the transcription factor C/EBPbeta.
Smink, J.J. and Leutz, A.
Gene 497 (1): 10-17. 10 April 2012

Genes & Development

C/EBPbetaDeltauORF mice--a genetic model for uORF-mediated translational control in mammals.
Wethmar, K. and Bégay, V. and Smink, J.J. and Zaragoza, K. and Wiesenthal, V. and Doerken, B. and Calkhoven, C.F. and Leutz, A.
Genes & Development 24 (1): 15-20. 1 January 2010

Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain.
Mo, X. and Kowenz-Leutz, E. and Laumonnier, Y. and Xu, H. and Leutz, A.
Genes & Development 19 (20): 2447-2457. 29 September 2005

Translational control of SCL-isoform expression in hematopoietic lineage choice.
Calkhoven, C.F. and Mueller, C. and Martin, R. and Krosl, G. and Hoang, T. and Leutz, A.
Genes & Development 17 (8): 959-964. 15 April 2003

Activation of the Notch-regulated transcription factor CBF1/RBP-J kappa through the 13SE1A oncoprotein.
Ansieau, S. and Strobl, L.J. and Leutz, A.
Genes & Development 15 (4): 380-385. 1 January 2001

Cooperation between C/EBP alphaTBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation.
Pedersen, T.A. and Kowenz-Leutz, E. and Leutz, A. and Nerlov, C.
Genes & Development 15 (21): 3208-3216. 1 January 2001

Translational control of C/EBP alpha and C/EBP beta isoform expression.
Calkhoven, C.F. and Mueller, C. and Leutz, A.
Genes & Development 14 (15): 1920-1932. 1 August 2000

Distinct C/EBP functions are required for eosinophil lineage commitment and maturation.
Nerlov, C. and McNagny, K.M. and Doederlein, G. and Kowenz-Leutz, E. and Graf, T.
Genes & Development 12 (15): 2413-2423. 1 August 1998

Novel mechanism of C/EBPbeta (NF-M) transcriptional control: activation through derepression.
Kowenz-Leutz, E. and Twamley, G. and Ansieau, S. and Leutz, A.
Genes & Development 8 (22): 2781-2791. 15 November 1994

Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types.
Ness, S.A. and Kowenz-Leutz, E. and Casini, T. and Graf, T. and Leutz, A.
Genes & Development 7 (5): 749-759. May 1993

Growth Factors

Recombinant murine erythropoietin receptor expressed in avian erythroid progenitors mediates terminal erythroid differentiation in vitro.
Steinlein, P. and Deiner, E. and Leutz, A. and Beug, H.
Growth Factors 10 (1): 1-16. 1994

Haematologica

Eukaryotic initiation factor 2α phosphorylation is required for B cell maturation and function in mice.
Mielke, N. and Schwarzer, R. and Calkhoven, C.F. and Kaufman, R. and Doerken, B. and Leutz, A. and Jundt, F.
Haematologica 96 (9): 1261-1268. September 2011

Immunity

Developmental and functional heterogeneity of monocytes.
Guilliams, M. and Mildner, A. and Yona, S.
Immunity 49 (4): 595-613. 16 October 2018

Genomic characterization of murine monocytes reveals C/EBPβ transcription factor dependence of Ly6C(-) cells.
Mildner, A. and Schönheit, J. and Giladi, A. and David, E. and Lara-Astiaso, D. and Lorenzo-Vivas, E. and Paul, F. and Chappell-Maor, L. and Priller, J. and Leutz, A. and Amit, I. and Jung, S.
Immunity 46 (5): 849-862. 16 May 2017

Immunity, inflammation and disease

Immune cell C/EBPβ deficiency is associated with hepatic mononuclear defects and spontaneous hepatitis but not steatohepatitis induced liver fibrosis.
Moshkovits, I. and Kaminitz, A. and Reuveni, D. and Pasmanik-Chor, M. and Brazowski, E. and Mildner, A. and Leutz, A. and Zigmond, E.
Immunity, inflammation and disease 10 (11): e728. November 2022

Immunobiology

Gene regulation by NF-M and Myb during differentiation and leukemic transformation.
Kowenz-Leutz, E. and Ansieau, S. and Twamley-Stein, G. and Ness, S.A. and Leutz, A.
Immunobiology 193 : 356-362. 1 January 1995

Journal of Biological Chemistry

Poly(ADP-ribosyl)ation of Methyl CpG binding domain protein 2 regulates chromatin structure.
Becker, A. and Zhang, P. and Allmann, L. and Meilinger, D. and Bertulat, B. and Eck, D. and Hofstaetter, M. and Bartolomei, G. and Hottiger, M.O. and Schreiber, V. and Leonhardt, H. and Cardoso, M.C.
Journal of Biological Chemistry 291 (10): 4873-4881. 4 March 2016

Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1.
Lausen, J. and Pless, O. and Leonard, F. and Kuvardina-Bolling, O.N. and Koch, B. and Leutz, A.
Journal of Biological Chemistry 285 (8): 5338-5346. 19 February 2010

G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta.
Pless, O. and Kowenz-Leutz, E. and Knoblich, M. and Lausen, J. and Beyerman, M. and Walsh, M.J. and Leutz, A.
Journal of Biological Chemistry 283 (39): 26357-26363. 26 September 2008

TNAP, a novel repressor of NF-kappaB-inducing kinase, suppresses NF-kappaB activation.
Hu, W.H. and Mo, X.M. and Walters, W.M. and Brambilla, R. and Bethea, J.R.
Journal of Biological Chemistry 279 (34): 35975-35983. 1 January 2004

The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest.
Mueller, C. and Calkhoven, C.F. and Sha, X.J. and Leutz, A.
Journal of Biological Chemistry 279 (8): 7353-7358. 1 January 2004

Phosphorylation-dependent down-regulation of c-Myb DNA binding is abrogated by a point mutation in the v-myb oncogene.
Andersson, K.B. and Kowenz-Leutz, E. and Brendeford, E.M. and Tygsett, A.H.H. and Leutz, A. and Gabrielsen, O.S.
Journal of Biological Chemistry 278 (6): 3816-3824. 7 February 2003

The conserved Mynd domain of BS69 binds cellular and oncoviral proteins through a common PXLXP motif.
Ansieau, S. and Leutz, A.
Journal of Biological Chemistry 277 (7): 4906-4910. 1 January 2002

Journal of Clinical Investigation

C/EBP beta regulation of the tumor necrosis factor alpha gene.
Pope, R.M. and Leutz, A. and Ness, S.A.
Journal of Clinical Investigation 94 (4): 1449-1455. October 1994

Journal of Experimental Medicine

Cross talk between Wnt/β-catenin and Irf8 in leukemia progression and drug resistance.
Scheller, M. and Schönheit, J. and Zimmermann, K. and Leser, U. and Rosenbauer, F. and Leutz, A.
Journal of Experimental Medicine 210 (11): 2239-2256. 21 October 2013

Journal of Immunology

Constitutive monocyte-restricted activity of NF-M, a nuclear factor that binds to a C/EBP motif.
Haas, J.G. and Stroebel, M. and Leutz, A. and Wendelgass, P. and Mueller, C. and Sterneck, E. and Riethmueller, G. and Ziegler-Heitbrock, H.W.
Journal of Immunology 149 (1): 237-243. 1 July 1992

Journal of Molecular Biology

Chromatin dynamics during differentiation of myeloid cells.
Schönheit, J. and Leutz, A. and Rosenbauer, F.
Journal of Molecular Biology 427 (3): 670-687. 13 February 2015

Journal of Molecular Endocrinology

Stable conditional expression and effect of C/EBPβ-LIP in adipocytes using the pSLIK system.
Esteves, C.L. and Kelly, V. and Bégay, V. and Lillico, S.G. and Leutz, A. and Seckl, J.R. and Chapman, K.
Journal of Molecular Endocrinology 51 (1): 91-98. 4 June 2013

Journal of Molecular Medicine

C/EBPβ regulates homeostatic and oncogenic gastric cell proliferation.
Regalo, G. and Förster, S. and Resende, C. and Bauer, B. and Fleige, B. and Kemmner, W. and Schlag, P.M. and Meyer, T.F. and Machado, J.C. and Leutz, A.
Journal of Molecular Medicine 94 (12): 1385-1395. December 2016

Deregulation of the endogenous C/EBPβ LIP isoform predisposes to tumorigenesis.
Bégay, V. and Smink, J.J. and Loddenkemper, C. and Zimmermann, K. and Rudolph, C. and Scheller, M. and Steinemann, D. and Leser, U. and Schlegelberger, B. and Stein, H. and Leutz, A.
Journal of Molecular Medicine 93 (1): 39-49. January 2015

Rapamycin inhibits osteoclast formation in giant cell tumor of bone through the C/EBPβ - MafB axis.
Smink, J.J. and Tunn, P.U. and Leutz, A.
Journal of Molecular Medicine 90 (1): 25-30. January 2012

Rapamycin and the transcription factor C/EBPbeta as a switch in osteoclast differentiation: implications for lytic bone diseases.
Smink, J.J. and Leutz, A.
Journal of Molecular Medicine 88 (3): 227-233. March 2010

B-Myb, a repressed trans-activating protein.
Ansieau, S. and Kowenz-Leutz, E. and Dechend, R. and Leutz, A.
Journal of Molecular Medicine 75 (11-12): 815-819. November 1997

Leukemia

Essential role of c-myc in ara-C-induced differentiation of human erythroleukemia cells.
Baker, S.J. and Pawlita, M. and Leutz, A. and Hoelzer, D.
Leukemia 8 (8): 1309-1317. August 1994

Life Science Alliance

Myeloid transformation by MLL-ENL depends strictly on C/EBP.
Wesolowski, R. and Kowenz-Leutz, E. and Zimmermann, K. and Dörr, D. and Hofstätter, M. and Slany, R.K. and Mildner, A. and Leutz, A.
Life Science Alliance 4 (1): e202000709. January 2021

A C/EBPα-Wnt connection in gut homeostasis and carcinogenesis.
Heuberger, J. and Hill, U. and Förster, S. and Zimmermann, K. and Malchin, V. and Kühl, A.A. and Stein, U. and Vieth, M. and Birchmeier, W. and Leutz, A.
Life Science Alliance 2 (1): e201800173. February 2019

Macromolecular Symposia

A high content screening assay for evaluation of biomaterial-mediated cell fusion processes.
Rijckaert, B. and Neffe, A.T. and Roch, T. and Gebauer, T. and Pierce, B.F. and Görs, J. and Smink, J.J. and Gossen, M. and Lendlein, A. and Leutz, A.
Macromolecular Symposia 346 (1): 91-99. December 2014

Mechanisms of Development

Expression of the homeobox gene GBX2 during chicken development.
Niss, K. and Leutz, A.
Mechanisms of Development 76 (1-2): 151-155. August 1998

Molecular & Cellular Proteomics

A universal peptide matrix interactomics approach to disclose motif dependent protein binding.
Ramberger, E. and Suarez-Artiles, L. and Perez-Hernandez, D. and Haji, M. and Popp, O. and Reimer, U. and Leutz, A. and Dittmar, G. and Mertins, P.
Molecular & Cellular Proteomics 20 : 100135. 13 August 2021

Molecular Cell

Ras induces mediator complex exchange on C/EBPβ.
Mo, X.M. and Kowenz-Leutz, E. and Xu, H. and Leutz, A.
Molecular Cell 13 (2): 241-250. 30 January 2004

A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.
Bourbon, H.M. and Aguilera, A. and Ansari, A.Z. and Asturias, F.J. and Berk, A.J. and Bjorklund, S. and Blackwell, T.K. and Borggrefe, T. and Carey, M. and Carlson, M. and Conaway, J.W. and Conaway, R.C. and Emmons, S.W. and Fondell, J.D. and Freedman, L.P. and Fukasawa, T. and Gustafsson, C.M. and Han, M. and He, X. and Herman, P.K. and Hinnebusch, A.G. and Holmberg, S. and Holstege, F.C. and Jaehning, J.A. and Kim, Y.J. and Kuras, L. and Leutz, A. and Lis, J.T. and Meisterernest, M. and Naar, A.M. and Nasmyth, K. and Parvin, J.D. and Ptashne, M. and Reinberg, D. and Ronne, H. and Sadowski, I. and Sakurai, H. and Sipiczki, M. and Sternberg, P.W. and Stillman, D.J. and Strich, R. and Struhl, K. and Svejstrup, J.Q. and Tuck, S. and Winston, F. and Roeder, R.G. and Kornberg, R.D.
Molecular Cell 14 (5): 553-557. 1 January 2004

A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes.
Kowenz-Leutz, E. and Leutz, A.
Molecular Cell 4 (5): 735-743. November 1999

Molecular and Cellular Biology

Repression of transcriptional activity of C/EBPα by E2F-DP complexes.
Zaragoza, K. and Bégay, V. and Schuetz, A. and Heinemann, U. and Leutz, A.
Molecular and Cellular Biology 30 (9): 2293-2304. May 2010

Essential requirement of CCAAT/enhancer binding proteins in embryogenesis.
Bégay, V. and Smink, J. and Leutz, A.
Molecular and Cellular Biology 24 (22): 9744-9751. 1 November 2004

Structure of the chicken myelomonocytic growth factor gene and specific activation of its promoter in avian myelomonocytic cells by protein kinases.
Sterneck, E. and Blattner, C. and Graf, T. and Leutz, A.
Molecular and Cellular Biology 12 (4): 1728-1735. April 1992

Nature

Identification of environmental factors that promote intestinal inflammation.
Sanmarco, L.M. and Chao, C.C. and Wang, Y.C. and Kenison, J.E. and Li, Z. and Rone, J.M. and Rejano-Gordillo, C.M. and Polonio, C.M. and Gutierrez-Vazquez, C. and Piester, G. and Plasencia, A. and Li, L. and Giovannoni, F. and Lee, H.G. and Faust Akl, C. and Wheeler, M.A. and Mascanfroni, I. and Jaronen, M. and Alsuwailm, M. and Hewson, P. and Yeste, A. and Andersen, B.M. and Franks, D.G. and Huang, C.J. and Ekwudo, M. and Tjon, E.C. and Rothhammer, V. and Takenaka, M. and de Lima, K.A. and Linnerbauer, M. and Guo, L. and Covacu, R. and Queva, H. and Fonseca-Castro, P.H. and Bladi, M.A. and Cox, L.M. and Hodgetts, K.J. and Hahn, M.E. and Mildner, A. and Korzenik, J. and Hauser, R. and Snapper, S.B. and Quintana, F.J.
Nature 611 (7937): 801-809. 24 November 2022

Nature Communications

Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ.
Rehm, A. and Gätjen, M. and Gerlach, K. and Scholz, F. and Mensen, A. and Gloger, M. and Heinig, K. and Lamprecht, B. and Mathas, S. and Bégay, V. and Leutz, A. and Lipp, M. and Dörken, B. and Höpken, U.E.
Nature Communications 5 : 5057. 30 September 2014

Nature Genetics

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.
Broeske, A.M. and Vockentanz, L. and Kharazi, S. and Huska, M.R. and Mancini, E. and Scheller, M. and Kuhl, C. and Enns, A. and Prinz, M. and Jaenisch, R. and Nerlov, C. and Leutz, A. and Andrade-Navarro, M.A. and Jacobsen, S.E. and Rosenbauer, F.
Nature Genetics 41 (11): 1207-1215. November 2009

Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1.
Rosenbauer, F. and Owens, B.M. and Yu, L. and Tumang, J.R. and Steidl, U. and Kutok, J.L. and Clayton, L.K. and Wagner, K. and Scheller, M. and Iwasaki, H. and Liu, C. and Hackanson, B. and Akashi, K. and Leutz, A. and Rothstein, T.L. and Plass, C. and Tenen, D.G.
Nature Genetics 38 (1): 27-37. January 2006

Nature Immunology

Cxcl10(+) monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation.
Giladi, A. and Wagner, L.K. and Li, H. and Dörr, D. and Medaglia, C. and Paul, F. and Shemer, A. and Jung, S. and Yona, S. and Mack, M. and Leutz, A. and Amit, I. and Mildner, A.
Nature Immunology 21 (5): 525-534. May 2020

Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor.
Grajales-Reyes, G.E. and Iwata, A. and Albring, J. and Wu, X. and Tussiwand, R. and Kc, W. and Kretzer, N.M. and Briseno, C.G. and Durai, V. and Bagadia, P. and Haldar, M. and Schoenheit, J. and Rosenbauer, F. and Murphy, T.L. and Murphy, K.M.
Nature Immunology 16 (7): 708-717. July 2015

Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation.
Scheller, M. and Huelsken, J. and Rosenbauer, F. and Taketo, M.M. and Birchmeier, W. and Tenen, D.G. and Leutz, A.
Nature Immunology 7 (10): 1037-1047. October 2006

Nature Protocols

A differential proteome screening system for post-translational modification-dependent transcription factor interactions.
Pless, O. and Kowenz-Leutz, E. and Dittmar, G. and Leutz, A.
Nature Protocols 6 (3): 359-364. February 2011

Analysis of translation initiation using a translation control reporter system.
Wiesenthal, V. and Leutz, A. and Calkhoven, C.F.
Nature Protocols 1 (3): 1531-1537. 9 November 2006

Neural Regeneration Research

Ghosts in the shell: identification of microglia in the human central nervous system by P2Y12 receptor.
Mildner, A.
Neural Regeneration Research 12 (4): 570-571. April 2017

Nucleic Acids Research

Modes of TAL effector-mediated repression.
Werner, J. and Gossen, M.
Nucleic Acids Research 42 (21): 13061-13073. 1 December 2014

uORFdb - a comprehensive literature database on eukaryotic uORF biology.
Wethmar, K. and Barbosa-Silva, A. and Andrade-Navarro, M.A. and Leutz, A.
Nucleic Acids Research 42 (1): D60-D67. 1 January 2014

A translation control reporter system (TCRS) for the analysis of translationally controlled processes in the vertebrate cell.
Wiesenthal, V. and Leutz, A. and Calkhoven, C.F.
Nucleic Acids Research 34 (3): e23. 10 February 2006

Oncogene

Comprehensive translational control of tyrosine kinase expression by upstream open reading frames.
Wethmar, K. and Schulz, J. and Muro, E.M. and Talyan, S. and Andrade-Navarro, M.A. and Leutz, A.
Oncogene 35 (13): 1736-1742. 31 March 2016

ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO.
Lausen, J. and Liu, S. and Fliegauf, M. and Luebbert, M. and Werner, M.H.
Oncogene 25 (9): 1349-1357. 2 March 2006

HNF4alpha reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma.
Lucas, B. and Grigo, K. and Erdmann, S. and Lausen, J. and Klein-Hitpass, L. and Ryffel, G.U.
Oncogene 24 (42): 6418-6431. 22 September 2005

Distinct changes in gene expression induced by A-Myb, B-Myb and c-Myb proteins.
Rushton, J.J. and Davis, L.M. and Lei, W.L. and Mo, X.M. and Leutz, A. and Ness, S.A.
Oncogene 22 (2): 308-313. 16 January 2003

Tumorigenic N-terminal deletions of c-Myb modulate DNA binding, transactivation, and cooperativity with C/EBP.
Oelgeschlager, M. and Kowenz-Leutz, E. and Schreek, S. and Leutz, A. and Luescher, B.
Oncogene 20 (50): 7420-7424. 1 January 2001

The Bcl-3 oncoprotein acts as a bridging factor between NF-kappa B/Rel and nuclear co-regulators.
Dechend, R. and Hirano, F. and Lehmann, K. and Heissmeyer, V. and Ansieau, S. and Wulczyn, F.G. and Scheidereit, C. and Leutz, A.
Oncogene 18 : 3316-3323. 3 June 1999

The BTB/POZ domain targets the LAZ3/BCL6 oncoprotein to nuclear dots and mediates homomerisation in vivo.
Dhordain, P. and Albagli, O. and Ansieau, S. and Koken, M. and Deweindt, C. and Quief, S. and Lantoine, D. and Leutz, A. and Kerckaert, J.P. and Leprince, D.
Oncogene 11 (12): 2689-2697. 21 December 1995

Oncotarget

Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients.
Szasz, A.M. and Lanczky, A. and Nagy, A. and Foerster, S. and Hark, K. and Green, J.E. and Boussioutas, A. and Busuttil, R. and Szabo, A. and Gyorffy, B.
Oncotarget 7 (31): 49322-49333. 2 August 2016

PLoS ONE

Lymphoid to myeloid cell trans-differentiation is determined by C/EBPβ structure and post-translational modifications.
Stoilova, B. and Kowenz-Leutz, E. and Scheller, M. and Leutz, A.
PLoS ONE 8 (6): e65169. 5 June 2013

Direct homo- and hetero-interactions of MeCP2 and MBD2.
Becker, A. and Allmann, L. and Hofstätter, M. and Casa, V. and Weber, P. and Lehmkuhl, A. and Herce, H.D. and Cardoso, M.C.
PLoS ONE 8 (1): e53730. 15 January 2013

Regulation of adipocyte 11beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) by CCAAT/enhancer-binding protein (C/EBP) beta isoforms, LIP and LAP.
Esteves, C.L. and Kelly, V. and Bégay, V. and Man, T.Y. and Morton, N.M. and Leutz, A. and Seckl, J.R. and Chapman, K.E.
PLoS ONE 7 (5): e37953. 25 May 2012

Streamlining homogeneous glycoprotein production for biophysical and structural applications by targeted cell line development.
Wilke, S. and Groebe, L. and Maffenbeier, V. and Jaeger, V. and Gossen, M. and Josewski, J. and Duda, A. and Polle, L. and Owens, R.J. and Wirth, D. and Heinz, D.W. and van den Heuvel, J. and Buessow, K.
PLoS ONE 6 (12): e27829. December 2011

Proceedings of the National Academy of Sciences of the United States of America

The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.
Scholz, F. and Grau, M. and Menzel, L. and Graband, A. and Zapukhlyak, M. and Leutz, A. and Janz, M. and Lenz, G. and Rehm, A. and Höpken, U.E.
Proceedings of the National Academy of Sciences of the United States of America 117 (42): 26328-26339. 20 October 2020

Separation of C/EBP alpha-mediated proliferation arrest and differentiation pathways.
Mueller, C. and Alunni-Fabroni, M. and Kowenz-Leutz, E. and Mo, X.M. and Tommasino, M. and Leutz, A.
Proceedings of the National Academy of Sciences of the United States of America 96 : 7276-7281. 22 June 1999

Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein.
Dhordain, P. and Albagli, O. and Lin, R.J. and Ansieau, S. and Quief, S. and Leutz, A. and Kerckaert, J.P. and Evans, R.M. and Leprince, D.
Proceedings of the National Academy of Sciences of the United States of America 94 (20): 10762-10767. 30 September 1997

Protein Science

Glycoprotein production for structure analysis with stable, glycosylation mutant CHO cell lines established by fluorescence-activated cell sorting.
Wilke, S. and Krausze, J. and Gossen, M. and Groebe, L. and Jaeger, V. and Gherardi, E. and van den Heuvel, J. and Buessow, K.
Protein Science 19 (6): 1264-1271. June 2010

Science

Mapping the lung.
Mildner, A. and Yona, S.
Science 363 (6432): 1154-1155. 15 March 2019

Science Immunology

C/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages.
Dörr, D. and Obermayer, B. and Weiner, J.M. and Zimmermann, K. and Anania, C. and Wagner, L.K. and Lyras, E.M. and Sapozhnikova, V. and Lara-Astiaso, D. and Prósper, F. and Lang, R. and Lupiáñez, D.G. and Beule, D. and Höpken, U.E. and Leutz, A. and Mildner, A.
Science Immunology 7 (75): eabj0140. September 2022

Good things come in threes.
Yona, S. and Mildner, A.
Science Immunology 3 (30): eaav5545. 7 December 2018

Scientific Reports

The C/EBPβ LIP isoform rescues loss of C/EBPβ function in the mouse.
Bégay, V. and Baumeier, C. and Zimmermann, K. and Heuser, A. and Leutz, A.
Scientific Reports 8 (1): 8417. 30 May 2018

Loss-of-function uORF mutations in human malignancies.
Schulz, J. and Mah, N. and Neuenschwander, M. and Kischka, T. and Ratei, R. and Schlag, P.M. and Castaños-Vélez, E. and Fichtner, I. and Tunn, P.U. and Denkert, C. and Klaas, O. and Berdel, W.E. and von Kries, J.P. and Makalowski, W. and Andrade-Navarro, M.A. and Leutz, A. and Wethmar, K.
Scientific Reports 8 (1): 2395. 5 February 2018

Stem Cell Reports

C/EBPβ-induced lymphoid-to-myeloid transdifferentiation emulates granulocyte-monocyte progenitor biology.
Nguyen, L.T. and Zimmermann, K. and Kowenz-Leutz, E. and Lim, R. and Hofstätter, M. and Mildner, A. and Leutz, A.
Stem Cell Reports 28 December 2023

C/EBP-induced transdifferentiation reveals granulocyte-macrophage precursor-like plasticity of B cells.
Cirovic, B. and Schönheit, J. and Kowenz-Leutz, E. and Ivanovska, J. and Klement, C. and Pronina, N. and Bégay, V. and Leutz, A.
Stem Cell Reports 14 (8): 346-359. 14 February 2017

Stem Cells

Downregulation of odd-skipped related 2, a novel regulator of epithelial-mesenchymal transition, enables efficient somatic cell reprogramming.
Anh, L.P.H. and Nishimura, K. and Kuno, A. and Nguyen, T.L. and Kato, T. and Ohtaka, M. and Nakanishi, M. and Sugihara, E. and Sato, T.A. and Hayashi, Y. and Fukuda, A. and Hisatake, K.
Stem Cells 40 (4): 397-410. 29 April 2022

Transcription

Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs.
Leutz, A. and Pless, O. and Lappe, M. and Dittmar, G. and Kowenz-Leutz, E.
Transcription 2 (1): 3-8. January 2011

Transgenic Research

Tet-Transgenic Rodents: a comprehensive, up-to date database.
Schoenig, K. and Freundlieb, S. and Gossen, M.
Transgenic Research 22 (2): 251-254. April 2013

Development of a BAC vector for integration-independent and tight regulation of transgenes in rodents via the Tet system.
Schoenig, K. and Kentner, D. and Gossen, M. and Baldinger, T. and Miao, J. and Welzel, K. and Vente, A. and Bartsch, D. and Bujard, H.
Transgenic Research 20 (3): 709-720. June 2011

Trends in Molecular Medicine

Translational control of gene expression and disease.
Calkhoven, C.F. and Mueller, C. and Leutz, A.
Trends in Molecular Medicine 8 (12): 577-583. 1 December 2002

Wiley Interdisciplinary Reviews: RNA

The regulatory potential of upstream open reading frames in eukaryotic gene expression.
Wethmar, K.
Wiley Interdisciplinary Reviews: RNA 5 (6): 765-768. November 2014

Zellbiologie Aktuell

Molecular genetics of hematopoiesis & leukemogenesis.
Leutz, A.
Zellbiologie Aktuell 30 (3): 16-18. May 2004

bioRxiv

A comprehensive motifs-based interactome of the C/EBPα transcription factor.
Ramberger, E. and Sapozhnikova, V. and Kowenz-Leutz, E. and Zimmermann, K. and Nicot, N. and Nazarov, P.V. and Perez-Hernandez, D. and Reimer, U. and Mertins, P. and Dittmar, G. and Leutz, A.
bioRxiv : 2020.12.28.424569. 28 December 2020

Protein Interaction Screen on Peptide Matrix (PRISMA) reveals interaction footprints and the PTM-dependent interactome of intrinsically disordered C/EBPβ.
Dittmar, G. and Perez-Hernandez, D. and Kowenz-Leutz, E. and Kirchner, M. and Kahlert, G. and Wesolowski, R. and Baum, K. and Knoblich, M. and Muller, A. and Wolf, J. and Reimer, U. and Leutz, A.
bioRxiv : 238709. 22 December 2017

eLife

Carm1-arginine methylation of the transcription factor C/EBPα regulates transdifferentiation velocity.
Torcal Garcia, G. and Kowenz-Leutz, E. and Tian, T.V and Klonizakis, A. and Lerner, J. and De Andres-Aguayo, L. and Sapozhnikova, V. and Berenguer, C. and Carmona, M.P. and Casadesus, M.V. and Bulteau, R. and Francesconi, M. and Peiro, S. and Mertins, P. and Zaret, K. and Leutz, A. and Graf, T.
eLife 12 : e83951. 27 June 2023

Tongue immune compartment analysis reveals spatial macrophage heterogeneity.
Lyras, E.M. and Zimmermann, K. and Wagner, L.K. and Dörr, D. and Klose, C.S.N and Fischer, C. and Jung, S. and Yona, S. and Hovav, A.H. and Stenzel, W. and Dommerich, S. and Conrad, T. and Leutz, A. and Mildner, A.
eLife 11 : 77490. 24 June 2022

iScience

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.
Ramberger, E. and Sapozhnikova, V. and Kowenz-Leutz, E. and Zimmermann, K. and Nicot, N. and Nazarov, P.V. and Perez-Hernandez, D. and Reimer, U. and Mertins, P. and Dittmar, G. and Leutz, A.
iScience 24 (6): 102686. 25 June 2021

PRISMA: Protein Interaction Screen on Peptide Matrix reveals interaction footprints and modifications- dependent interactome of intrinsically disordered C/EBPb.
Dittmar, G. and Perez Hernandez, D. and Kowenz-Leutz, E. and Kirchner, M. and Kahlert, G. and Wesolowski, R. and Baum, K. and Knoblich, M. and Hofstätter, M. and Muller, A. and Wolf, J. and Reimer, U. and Leutz, A.
iScience 13 : 351-370. 29 March 2019