2024
Extracellular matrix remodeling in atopic dermatitis harnesses the onset of an asthmatic phenotype and is a potential contributor to the atopic march.
Graff, P., Woerz, D., Wilzopolski, J., Voss, A., Sarrazin, J., Blimkie, T.M., Weiner, J., Kershaw, O., Panwar, P., Hackett, T., Lau, S., Brömme, D., Beule, D., Lee, Y.A., Hancock, R.E.W., Gruber, A.D., Bäumer, W. and Hedtrich, S.
Journal of Investigative Dermatology 144
(5): 1010-1021.
May 2024
Tolerance induction through early feeding to prevent food allergy in infants and children with sensitization against food allergens (TIFFANI): rationale, study design, and methods of a randomized controlled trial.
Kalb, B., Meixner, L., Heller, S., Dölle-Bierke, S., Roll, S., Tissen-Diabaté, T., Lau, S., Forslund, S., Marenholz, I., Lee, Y.A., Thiel, A., Babina, M., Scheffel, J., Worm, M. and Beyer, K.
Trials 25
: 272.
19 April 2024
2023
European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.
Budu-Aggrey, A., Kilanowski, A., Sobczyk, M.K., Shringarpure, S.S., Mitchell, R., Reis, K., Reigo, A., Mägi, R., Nelis, M., Tanaka, N., Brumpton, B.M., Thomas, L.F., Sole-Navais, P., Flatley, C., Espuela-Ortiz, A., Herrera-Luis, E., Lominchar, J.V.T., Bork-Jensen, J., Marenholz, I., Arnau-Soler, A., Jeong, A., Fawcett, K.A., Baurecht, H., Rodriguez, E., Alves, A.C., Kumar, A., Sleiman, P.M., Chang, X., Medina-Gomez, C., Hu, C., Xu, C.J., Qi, C., El-Heis, S., Titcombe, P., Antoun, E., Fadista, J., Wang, C.A., Thiering, E., Wu, B., Kress, S., Kothalawala, D.M., Kadalayil, L., Duan, J., Zhang, H., Hadebe, S., Hoffmann, T., Jorgenson, E., Choquet, H., Risch, N., Njølstad, P., Andreassen, O.A., Johansson, S., Almqvist, C., Gong, T., Ullemar, V., Karlsson, R., Magnusson, P.K.E., Szwajda, A., Burchard, E.G., Thyssen, J.P., Hansen, T., Kårhus, L.L., Dantoft, T.M., Jeanrenaud, A.C.S.N., Ghauri, A., Arnold, A., Homuth, G., Lau, S., Nöthen, M.M., Hübner, N., Imboden, M., Visconti, A., Falchi, M., Bataille, V., Hysi, P., Ballardini, N., Boomsma, D.I., Hottenga, J.J., Müller-Nurasyid, M., Ahluwalia, T.S., Stokholm, J., Chawes, B., Schoos, A.M.M., Esplugues, A., Bustamante, M., Raby, B., Arshad, S., German, C., Esko, T., Milani, L.A., Metspalu, A., Terao, C., Abuabara, K., Løset, M., Hveem, K., Jacobsson, B., Pino-Yanes, M., Strachan, D.P., Grarup, N., Linneberg, A., Lee, Y., Probst-Hensch, N., Weidinger, S., Jarvelin, M.R., Melén, E., Hakonarson, H., Irvine, A.D., Jarvis, D., Nijsten, T., Duijts, L., Vonk, J.M., Koppelmann, G.H., Godfrey, K.M., Barton, S.J., Feenstra, B., Pennell, C.E., Sly, P.D., Holt, P.G., Williams, L.K., Bisgaard, H., Bønnelykke, K., Curtin, J., Simpson, A., Murray, C., Schikowski, T., Bunyavanich, S., Weiss, S.T., Holloway, J.W., Min, J.L., Brown, S.J., Standl, M. and Paternoster, L.
Nature Communications 14
(1): 6172.
4 October 2023
New insights from genetic studies of eczema.
Marenholz, I., Arnau-Soler, A., Rosillo-Salazar, O.D. and Lee, Y.A.
Medizinische Genetik 35
(1): 33-45.
5 April 2023
2022
Filaggrin loss-of-function mutations are associated with persistence of egg and milk allergy.
Kalb, B., Marenholz, I., Jeanrenaud, A.C.S.N., Meixner, L., Arnau-Soler, A., Rosillo-Salazar, O.D., Ghauri, A., Cibin, P., Blümchen, K., Schlags, R., Hansen, G., Seidenberg, J., Keil, T., Lau, S., Niggemann, B., Beyer, K. and Lee, Y.A.
Journal of Allergy and Clinical Immunology 150
(5): 1125-1134.
November 2022
An interdisciplinary approach to characterize peanut-allergic patients - first data from the FOOD@ consortium.
Worm, M., Alexiou, A., Höfer, V., Birkner, T., Jeanrenaud, A.C.S.N., Fauchère, F., Pazur, K., Steinert, C., Arnau-Soler, A., Banerjee, P., Diefenbach, A., Dobbertin-Welsch, J., Dölle-Bierke, S., Francuzik, W., Ghauri, A., Heller, S., Kalb, B., Löber, U., Marenholz, I., Markó, L., Scheffel, J., Potapenko, O., Roll, St., Lau, S., Lee, Y.A., Braun, J., Thiel, A., Babina, M., Altrichter, S., Forslund, S.K. and Beyer, K.
Clinical and Translational Allergy 12
(10): e12197.
October 2022
Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.
Reichart, D., Lindberg, E.L., Maatz, H., Miranda, A.M.A., Viveiros, A., Shvetsov, N., Gärtner, A., Nadelmann, E.R., Lee, M., Kanemaru, K., Ruiz-Orera, J., Strohmenger, V., DeLaughter, D.M., Patone, G., Zhang, H., Woehler, A., Lippert, C., Kim, Y., Adami, E., Gorham, J.M., Barnett, S.N., Brown, K., Buchan, R.J., Chowdhury, R.A., Constantinou, C., Cranley, J., Felkin, L.E., Fox, H., Ghauri, A., Gummert, J., Kanda, M., Li, R., Mach, L., McDonough, B., Samari, S., Shahriaran, F., Yapp, C., Stanasiuk, C., Theotokis, P.I., Theis, F.J., van den Bogaerdt, A., Wakimoto, H., Ware, J.S., Worth, C.L., Barton, P.J.R., Lee, Y.A., Teichmann, S.A., Milting, H., Noseda, M., Oudit, G.Y., Heinig, M., Seidman, J.G., Hubner, N. and Seidman, C.E.
Science 377
(6606): eabo1984.
5 August 2022
Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations.
Nimptsch, K., Aleksandrova, K., Fedirko, V., Jenab, M., Gunter, M.J., Siersema, P.D., Wu, K., Katzke, V., Kaaks, R., Panico, S., Palli, D., May, A.M., Sieri, S., Bueno-de-Mesquita, B., Standahl, K., Sánchez, M.J., Perez-Cornago, A., Olsen, A., Tjønneland, A., Bonet, C.B., Dahm, C.C., Chirlaque, M.D., Fiano, V., Tumino, R., Barricarte Gurrea, A., Boutron-Ruault, M.C., Menegaux, F., Severi, G., van Guelpen, B., Lee, Y.A. and Pischon, T.
BMC Cancer 22
(1): 695.
24 June 2022
Tolerance induction through non-avoidance to prevent persistent food allergy (TINA) in children and adults with peanut or tree nut allergy: rationale, study design and methods of a randomized controlled trial and observational cohort study.
Trendelenburg, V., Dölle-Bierke, S., Unterleider, N., Alexiou, A., Kalb, B., Meixner, L., Heller, S., Lau, S., Lee, Y.A., Fauchère, F., Braun, J., Babina, M., Altrichter, S., Birkner, T., Roll, S., Dobbertin-Welsch, J., Worm, M. and Beyer, K.
Trials 23
(1): 236.
28 March 2022
Tolerance induction through early feeding to prevent food allergy in infants with eczema (TEFFA): rationale, study design, and methods of a randomized controlled trial.
Kalb, B., Meixner, L., Trendelenburg, V., Unterleider, N., Dobbertin-Welsch, J., Heller, S., Dölle-Bierke, S., Roll, S., Lau, S., Lee, Y.A., Fauchère, F., Braun, J., Babina, M., Altrichter, S., Birkner, T., Worm, M. and Beyer, K.
Trials 23
(1): 210.
12 March 2022
2021
Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4.
Grosche, S., Marenholz, I., Esparza-Gordillo, J., Arnau-Soler, A., Pairo-Castineira, E., Rüschendorf, F., Ahluwalia, T.S., Almqvist, C., Arnold, A., Baurecht, H., Bisgaard, H., Bønnelykke, K., Brown, S.J., Bustamante, M., Curtin, J.A., Custovic, A., Dharmage, S.C., Esplugues, A., Falchi, M., Fernandez-Orth, D., Ferreira, M.A.R., Franke, A., Gerdes, S., Gieger, C., Hakonarson, H., Holt, P.G., Homuth, G., Hubner, N., Hysi, P.G., Jarvelin, M.R., Karlsson, R., Koppelman, G.H., Lau, S., Lutz, M., Magnusson, P.K.E., Marks, G.B., Müller-Nurasyid, M., Nöthen, M.M., Paternoster, L., Pennell, C.E., Peters, A., Rawlik, K., Robertson, C.F., Rodriguez, E., Sebert, S., Simpson, A., Sleiman, P.M.A., Standl, M., Stölzl, D., Strauch, K., Szwajda, A., Tenesa, A., Thompson, P.J., Ullemar, V., Visconti, A., Vonk, J.M., Wang, C.A., Weidinger, S., Wielscher, M., Sargent, C.L., Xu, C.J. and Lee, Y.A.
Nature Communications 12
(1): 6618.
16 November 2021
2020
Age-of-onset information helps identify 76 genetic variants associated with allergic disease.
Ferreira, M.A.R., Vonk, J.M., Baurecht, H., Marenholz, I., Tian, C., Hoffman, J.D., Helmer, Q., Tillander, A., Ullemar, Vi., Lu, Y., Grosche, S., Rüschendorf, F., Granell, R., Brumpton, B.M., Fritsche, L.G., Bhatta, L., Gabrielsen, M.E., Nielsen, J.B., Zhou, W., Hveem, K., Langhammer, A., Holmen, O.L., Løset, M., Abecasis, G.R., Willer, C.J., Emami, N.C., Cavazos, T.B., Witte, J.S., Szwajda, A., Hinds, D.A., Hübner, N., Weidinger, S., Magnusson, P.K., Jorgenson, E., Karlsson, R., Paternoster, L., Boomsma, D.I., Almqvist, C., Lee, Y.A. and Koppelman, G.H.
PLoS Genetics 16
(6): e1008725.
30 June 2020
Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis.
Thyssen, J.P., Ahluwalia, T.S., Paternoster, L., Ballardini, N., Bergström, A., Melén, E., Chawes, B., Stokholm, J., Hourihane, J.O., O'Sullivan, D.M., Bager, P., Maelbye, M., Bustamante, M., Torrent, M., Esplugues, A., Duijts, L., Hu, C., Elbert, N.J., Pasmans, S.G.M.A., Nijsten, T.E C., von Berg, A., Standl, M., Schikowski, T., Herberth, G., Heinrich, J., Lee, Y.A., Marenholz, I., Lau, S., Curtin, J.A., Simpson, A., Custovic, A., Pennell, C.E., Wang, C.A., Holt, P.G., Bisgaard, H. and Bønnelykke, K.
Allergy 75
(6): 1481-1485.
June 2020
Phenotype consensus is required to enable large-scale genetic consortium studies of food allergy.
Asai, Y., Martino, D., Eiwegger, T., Nadeau, K., Koppelman, G.H., Clarke, A.E., Lee, Y.A., Chan, E.S., Simons, E., Laprise, C., Mazer, B., Marenholz, I., Royce, D., Elliott, S.J., Hampson, C., Gerdts, J., Eslami, A., Soller, L., Hui, J., Azad, M., Sandford, A. and Daley, D.
Allergy 75
(9): 2383-2387.
23 April 2020
Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression.
Mucha, S., Baurecht, H., Novak, N., Rodríguez, E., Bej, S., Mayr, G., Emmert, H., Stölzl, D., Gerdes, S., Degenhardt, F., Hübenthal, M., Ellinghaus, E., Jung, E.S., Kässens, J.C., Wienbrandt, L., Lieb, W., Müller-Nurasyid, M., Hotze, M., Dand, N., Grosche, S., Marenholz, I., Arnold, A., Homuth, G., Schmidt, C.O., Wehkamp, U., Nöthen, M.M., Hoffmann, P., Paternoster, L., Standl, M., Bønnelykke, K., Ahluwalia, T.S., Bisgaard, H., Peters, A., Gieger, C., Waldenberger, M., Schulz, H., Strauch, K., Werfel, T., Lee, Y.A., Wolfien, M., Rosenstiel, P., Wolkenhauer, O., Schreiber, St., Franke, A., Weidinger, S. and Ellinghaus, D.
Journal of Allergy and Clinical Immunology 145
(4): 1208-1218.
April 2020
2019
Eleven loci with new reproducible genetic associations with allergic disease risk.
Ferreira, M.A., Vonk, J.M., Baurecht, H., Marenholz, I., Tian, C., Hoffman, J.D., Helmer, Q., Tillander, A., Ullemar, V., Lu, Y., Rüschendorf, F., Hinds, D.A., Hübner, N., Weidinger, S., Magnusson, P.K., Jorgenson, E., Lee, Y.A., Boomsma, D.I., Karlsson, R., Almqvist, C., Koppelman, G.H. and Paternoster, L.
Journal of Allergy and Clinical Immunology 143
(2): 691-699.
February 2019
Allergy and atopy from infancy to adulthood: messages from the German birth cohort MAS.
Lau, S., Matricardi, P.M., Wahn, U., Lee, Y.A. and Keil, T.
Annals of Allergy, Asthma & Immunology 122
(1): 25-32.
January 2019
2018
Evaluation of food allergy candidate loci in the Genetics of Food Allergy Study.
Marenholz, I., Grosche, S., Rüschendorf, F., Kalb, B., Blumchen, K., Schlags, R., Harandi, N., Price, M., Hansen, G., Seidenberg, J., Yürek, S., Homuth, G., Schmidt, C.O., Nöthen, M.M., Hubner, N., Niggemann, B., Beyer, K. and Lee, Y.A.
Journal of Allergy and Clinical Immunology 142
(4): 1368-1370.
October 2018
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
Waage, J., Standl, M., Curtin, J.A., Jessen, L.E., Thorsen, J., Tian, C., Schoettler, N., Flores, C., Abdellaoui, A., Ahluwalia, T.S., Alves, A.C., Amaral, A.F.S., Antó, J.M., Arnold, A., Barreto-Luis, A., Baurecht, H., van Beijsterveldt, C.E.M., Bleecker, E.R., Bonàs-Guarch, S., Boomsma, D.I., Brix, S., Bunyavanich, S., Burchard, E.G., Chen, Z., Curjuric, I., Custovic, A., den Dekker, H.T., Dharmage, S.C., Dmitrieva, J., Duijts, L., Ege, M.J., Gauderman, W.J., Georges, M., Gieger, C., Gilliland, F., Granell, R., Gui, H., Hansen, T., Heinrich, J., Henderson, J., Hernandez-Pacheco, N., Holt, P., Imboden, M., Jaddoe, V.W.V., Jarvelin, M.R., Jarvis, D.L., Jensen, K.K., Jónsdóttir, I., Kabesch, M., Kaprio, J., Kumar, A., Lee, Y.A., Levin, A.M., Li, X., Lorenzo-Diaz, F., Melén, E., Mercader, J.M., Meyers, D.A., Myers, R., Nicolae, D.L., Nohr, E.A., Palviainen, T., Paternoster, L., Pennell, C.E., Pershagen, G., Pino-Yanes, M., Probst-Hensch, N.M., Rüschendorf, F., Simpson, A., Stefansson, K., Sunyer, J., Sveinbjornsson, G., Thiering, E., Thompson, P.J., Torrent, M., Torrents, D., Tung, J.Y., Wang, C.A., Weidinger, S., Weiss, S., Willemsen, G., Williams, L.K., Ober, C., Hinds, D.A., Ferreira, M.A., Bisgaard, H., Strachan, D.P. and Bønnelykke, K.
Nature Genetics 50
(8): 1072-1080.
August 2018
Candidate gene testing in clinical cohort studies with multiplexed genotyping and mass spectrometry.
Ashley, S.E., Meyer, B.A., Ellis, J.A. and Martino, D.J.
Journal of Visualized Experiments
(136): e57601.
21 June 2018
SMARCAD1 haploinsufficiency underlies Huriez syndrome and associated skin cancer susceptibility.
Günther, C., Lee-Kirsch, M.A., Eckhard, J., Matanovic, A., Kerscher, T., Rüschendorf, F., Klein, B., Berndt, N., Zimmermann, N., Flachmeier, C., Thuß, T., Lucas, N., Marenholz, I., Esparza-Gordillo, J., Hübner, N., Traupe, H., Delaporte, E. and Lee, Y.A.
Journal of Investigative Dermatology 138
(6): 1428-1431.
June 2018
A Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma.
Asai, Y., Eslami, A., van Ginkel, C.D., Akhabir, L., Wan, M., Yin, D., Ellis, G., Ben-Shoshan, M., Marenholz, I., Martino, D., Ferreira, M.A., Allen, K., Mazer, B., de Groot, H., de Jong, N.W., Gerth van Wijk, R., Dubois, A.E.J., Grosche, S., Ashley, S., Rüschendorf, F., Kalb, B., Beyer, K., Nöthen, M.M., Lee, Y.A., Chin, R., Cheuk, S., Hoffman, J., Jorgensen, E., Witte, J.S., Melles, R.B., Hong, X., Wang, X., Hui, J., Musk, A.W.B., Hunter, M., James, A.L., Koppelman, G.H., Sandford, A.J., Clarke, A.E. and Daley, D.
Journal of Allergy and Clinical Immunology 141
(4): 1513-1516.
April 2018
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Demenais, F., Margaritte-Jeannin, P., Barnes, K.C., Cookson, W.O.C., Altmüller, J., Ang, W., Barr, R.G., Beaty, T.H., Becker, A.B., Beilby, J., Bisgaard, H., Bjornsdottir, U.S., Bleecker, E., Bonnelykke, K., Boomsma, D.I., Bouzigon, E., Brightling, C.E., Brossard, M., Brusselle, G.G., Burchard, E., Burkart, K.M., Bush, A., Chan-Yeung, M., Chung, K.F., Couto Alves, A., Curtin, J.A., Custovic, A., Daley, D., de Jongste, J.C., Del-Rio-Navarro, B.E., Donohue, K.M., Duijts, L., Eng, C., Eriksson, J.G., Farrall, M., Fedorova, Y., Feenstra, B., Ferreira, M.A., Freidin, M.B., Gajdos, Z., Gauderman, J., Gehring, U., Geller, F., Genuneit, J., Gharib, S.A, Gilliland, F., Granell, R., Graves, P.E., Gudbjartsson, D.F., Haahtela, T., Heckbert, S.R., Heederik, D., Heinrich, J., Helioevaara, M., Henderson, J., Himes, B.E., Hirose, H., Hirschhorn, J.N., Hofman, A., Holt, P., Hottenga, J., Hudson, T.J., Hui, J., Imboden, M., Ivanov, V., Jaddoe, V.W.V., James, A., Janson, C., Jarvelin, M.R., Jarvis, D., Jones, G., Jonsdottir, I., Jousilahti, P., Kabesch, M., Kähönen, M., Kantor, D.B., Karunas, A.S., Khusnutdinova, E., Koppelman, G.H., Kozyrskyj, A.L., Kreiner, E., Kubo, M., Kumar, R., Kumar, A., Kuokkanen, M., Lahousse, L., Laitinen, T., Laprise, C., Lathrop, M., Lau, S., Lee, Y.A., Lehtimaeki, T., Letort, S., Levin, A.M., Li, G., Liang, L., Loehr, L.R., London, S.J., Loth, D.W., Manichaikul, A., Marenholz, I., Martinez, F.J., Matheson, M.C., Mathias, R.A., Matsumoto, K., Mbarek, H., McArdle, W.L., Melbye, M., Melen, E., Meyers, D., Michel, S., Mohamdi, H., Musk, A.W., Myers, R.A., Nieuwenhuis, M.A.E., Noguchi, E., O'Connor, G.T., Ogorodova, L.M., Palmer, C.D., Palotie, A., Park, J.E., Pennell, C.E., Pershagen, G., Polonikov, A., Postma, D.S., Probst-Hensch, N., Puzyrev, V.P., Raby, B.A., Raitakari, O.T., Ramasamy, A., Rich, S.S., Robertson, C.F., Romieu, I., Salam, M.T., Salomaa, V., Schluenssen, V., Scott, R., Selivanova, P.A., Sigsgaard, T., Simpson, A., Siroux, V., Smith, L.J., Solodilova, M., Standl, M., Stefansson, K., Strachan, D.P., Stricker, B.H., Takahashi, A., Thompson, P.J., Thorleifsson, G., Thorsteinsdottir, U., Tiesler, C.M.T., Torgerson, D.G., Tsunoda, T., Uitterlinden, A.G., van der Valk, R.J.P., Vaysse, A., Vedantam, S., von Berg, A., von Mutius, E., Vonk, J.M., Waage, J., Wareham, N.J., Weiss, S.T., White, W.B., Wickman, M., Widén, E., Willemsen, G., Williams, L.K., Wouters, I.M., Yang, J.J., Zhao, J.H., Moffatt, M.F., Ober, C. and Nicolae, D.L.
Nature Genetics 50
(1): 42-53.
January 2018
2017
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.
Ferreira, M.A., Vonk, J.M., Baurecht, H., Marenholz, I., Tian, C., Hoffman, J.D., Helmer, Q., Tillander, A., Ullemar, V., van Dongen, J., Lu, Yi, Rueschendorf, F., Esparza-Gordillo, J., Medway, C.W., Mountjoy, E., Burrows, K., Hummel, O., Grosche, S., Brumpton, B.M., Witte, J.S., Hottenga, J.J., Willemsen, G., Zheng, J., Rodriguez, E., Hotze, M., Franke, A., Revez, J.A., Beesley, J., Matheson, M.C., Dharmage, S.C., Bain, L.M., Fritsche, L.G., Gabrielsen, M.E., Balliu, B., Nielsen, J.B., Zhou, W., Hveem, K., Langhammer, A., Holmen, O.L., Løset, M., Abecasis, G.R., Willer, C.J., Arnold, A., Homuth, G., Schmidt, C.O., Thompson, P.J., Martin, N.G., Duffy, D.L., Novak, N., Schulz, H., Karrasch, S., Gieger, C., Strauch, K., Melles, R.B., Hinds, D.A., Hübner, N., Weidinger, S., Magnusson, P.K.E., Jansen, R., Jorgenson, E., Lee, Y.A., Boomsma, D.I., Almqvist, C., Karlsson, R., Koppelman, G.H. and Paternoster, L.
Nature Genetics 49
(12): 1752-1757.
December 2017
Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy.
Marenholz, I., Grosche, S., Kalb, B., Rüschendorf, F., Blümchen, K., Schlags, R., Harandi, N., Price, M., Hansen, G., Seidenberg, J., Röblitz, H., Yürek, S., Tschirner, S., Hong, X., Wang, X., Homuth, G., Schmidt, C.O., Nöthen, M.M., Hübner, N., Niggemann, B., Beyer, K. and Lee, Y.A.
Nature Communications 8
(1): 1056.
20 October 2017
Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies.
Nimptsch, K., Song, M., Aleksandrova, K., Katsoulis, M., Freisling, H., Jenab, M., Gunter, M.J., Tsilidis, K.K., Weiderpass, E., Bueno-De-Mesquita, H.B., Chong, D.Q., Jensen, M.K., Wu, C., Overvad, K., Kühn, T., Barrdahl, M., Melander, O., Jirstrom, K., Peeters, P.H., Sieri, S., Panico, S., Cross, A.J., Riboli, E., Van Guelpen, B., Myte, R., Huerta, J.M., Rodriguez-Barranco, M., Quirós, J.R., Dorronsoro, M., Tjønneland, A., Olsen, A., Travis, R., Boutron-Ruault, M.C., Carbonnel, F., Severi, G., Bonet, C., Palli, D., Janke, J., Lee, Y.A., Boeing, H., Giovannucci, E.L., Ogino, S., Fuchs, C.S., Rimm, E., Wu, K., Chan, A.T. and Pischon, T.
European Journal of Epidemiology 32
(5): 419-430.
May 2017
Genomewide association study of peanut allergy reproduces association with amino acid polymorphisms in HLA-DRB1.
Martino, D.J., Ashley, S., Koplin, J., Ellis, J., Saffery, R., Dharmage, S.C., Gurrin, L., Matheson, M.C., Kalb, B., Marenholz, I., Beyer, K., Lee, Y.A., Hong, X., Wang, X., Vukevic, D., Motyer, A., Leslie, S., Allen, K.J. and Ferreira, M.A.R.
Clinical and Experimental Allergy 47
(2): 217-223.
February 2017
2016
DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis.
Sarnowski, C., Laprise, C., Malerba, G., Moffatt, M.F., Dizier, M.H., Morin, A., Vincent, Q.B., Rohde, K., Esparza-Gordillo, J., Margaritte-Jeannin, P., Liang, L., Lee, Y.A., Bousquet, J., Siroux, V., Pignatti, P.F., Cookson, W.O., Lathrop, M., Pastinen, T., Demenais, F. and Bouzigon, E.
Journal of Allergy and Clinical Immunology 138
(3): 748-753.
September 2016
Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes.
Schmitt, J., Schwarz, K., Baurecht, H., Hotze, M., Fölster-Holst, R., Rodríguez, E., Lee, Y.A.E., Franke, A., Degenhardt, F., Lieb, W., Gieger, C., Kabesch, M., Nöthen, M.M., Irvine, A.D., McLean, W.H.I., Deckert, S., Stephan, V., Schwarz, P., Aringer, M., Novak, N. and Weidinger, S.
Journal of Allergy and Clinical Immunology 137
(1): 130-136.
January 2016
2015
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.
Paternoster, L., Standl, M., Waage, J., Baurecht, H., Hotze, M., Strachan, D.P., Curtin, J.A., Bønnelykke, K., Tian, C., Takahashi, A., Esparza-Gordillo, J., Alves, A.C., Thyssen, J.P., den Dekker, H.T., Ferreira, M.A., Altmaier, E., Sleiman, P.M.A., Xiao, F.L., Gonzalez, J.R., Marenholz, I., Kalb, B., Pino-Yanes, M., Xu, C.J., Carstensen, L., Groen-Blokhuis, M.M., Venturini, C., Pennell, C.E., Barton, S.J., Levin, A.M., Curjuric, I., Bustamante, M., Kreiner-Møller, E., Lockett, G.A., Bacelis, J., Bunyavanich, S., Myers, R.A., Matanovic, A., Kumar, A., Tung, J.Y., Hirota, T., Kubo, M., McArdle, W.L., Henderson, A.J., Kemp, J.P., Zheng, J., Smith, G.D., Rüschendorf, F., Bauerfeind, A., Lee-Kirsch, M.A., Arnold, A., Homuth, G., Schmidt, C.O., Mangold, E., Cichon, S., Keil, T., Rodríguez, E., Peters, A., Franke, A., Lieb, W., Novak, N., Fölster-Holst, R., Horikoshi, M., Pekkanen, J., Sebert, S., Husemoen, L.L., Grarup, N., de Jongste, J.C., Rivadeneira, F., Hofman, A., Jaddoe, V.W.V., Pasmans, S.G.M.A., Elbert, N.J., Uitterlinden, A.G., Marks, G.B., Thompson, P.J., Matheson, M.C., Robertson, C.F., Ried, J.S., Li, J., Zuo, X.B., Zheng, X.D., Yin, X.Y., Sun, L.D., McAleer, M.A., O'Regan, G.M., Fahy, C.M.R., Campbell, L.E., Macek, M., Kurek, M., Hu, D., Eng, C., Postma, D.S., Feenstra, B., Geller, F., Hottenga, J.J., Middeldorp, C.M., Hysi, P., Bataille, V., Spector, T., Tiesler, C.M.T., Thiering, E., Pahukasahasram, B., Yang, J.J., Imboden, M., Huntsman, S., Vilor-Tejedor, N., Relton, C.L., Myhre, R., Nystad, W., Custovic, A., Weiss, S.T., Meyers, D.A., Söderhäll, C., Melén, E., Ober, C., Raby, B.A., Simpson, A., Jacobsson, B., Holloway, J.W., Bisgaard, H., Sunyer, J., Probst-Hensch, N.M., Williams, L.K., Godfrey, K.M., Wang, C.A., Boomsma, D.I., Melbye, M., Koppelman, G.H., Jarvis, D., McLean, W.H.I., Irvine, A.D., Zhang, X.J., Hakonarson, H., Gieger, C., Burchard, E.G., Martin, N.G., Duijts, L., Linneberg, A., Jarvelin, M.R., Noethen, M.M., Lau, S., Hübner, N., Lee, Y.A., Tamari, M., Hinds, D.A., Glass, D., Brown, S.J., Heinrich, J., Evans, D.M. and Weidinger, S.
Nature Genetics 47
(12): 1449-1456.
December 2015
Meta-analysis identifies seven susceptibility loci involved in the atopic march.
Marenholz, I., Esparza-Gordillo, J., Rüschendorf, F., Bauerfeind, A., Strachan, D.P., Spycher, B.D., Baurecht, H., Margaritte-Jeannin, P., Sääf, A., Kerkhof, M., Ege, M., Baltic, S., Matheson, M.C., Li, J., Michel, S., Ang, W.Q., McArdle, W., Arnold, A., Homuth, G., Demenais, F., Bouzigon, E., Söderhäll, C., Pershagen, G., de Jongste, J.C., Postma, D.S., Braun-Fahrlaender, C., Horak, E., Ogorodova, L.M., Puzyrev, V.P., Bragina, E.Y., Hudson, T.J., Morin, C., Duffy, D.L., Marks, G.B., Robertson, C.F., Montgomery, G.W., Musk, B., Thompson, P.J., Martin, N.G., James, A., Sleiman, P., Toskala, E., Rodriguez, E., Fölster-Holst, R., Franke, A., Lieb, W., Gieger, C., Heinzmann, A., Rietschel, E., Keil, T., Cichon, S., Nöthen, M.M., Pennell, C.E., Sly, P.D., Schmidt, C.O., Matanovic, A., Schneider, V., Heinig, M., Hübner, N., Holt, P.G., Lau, S., Kabesch, M., Weidinger, S., Hakonarson, H., Ferreira, M.A.R., Laprise, C., Freidin, M.B., Genuneit, J., Koppelman, G.H., Melén, E., Dizier, M.H., Henderson, A.J. and Lee, Y.A.
Nature Communications 6
: 8804.
6 November 2015
Prediction and prevention of allergic rhinitis: A birth cohort study of 20 years.
Grabenhenrich, L.B., Keil, T., Reich, A., Gough, H., Beschorner, J., Hoffmann, U., Bauer, C.P., Forster, J., Schuster, A., Schramm, D., Nitsche, O., Zepp, F., Lee, Y.A., Bergmann, R., Bergmann, K., Wahn, U. and Lau, S.
Journal of Allergy and Clinical Immunology 136
(4): 932-940.
October 2015
The genetics of the skin barrier in eczema and other allergic disorders.
Marenholz, I., Esparza-Gordillo, J. and Lee, Y.A.
Current Opinion in Allergy and Clinical Immunology 15
(5): 426-434.
October 2015
A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis.
Schaarschmidt, H., Ellinghaus, D., Rodríguez, E., Kretschmer, A., Baurecht, H., Lipinski, S., Meyer-Hoffert, U., Harder, J., Lieb, W., Novak, N., Fölster-Holst, R., Esparza-Gordillo, J., Marenholz, I., Ruschendorf, F., Hubner, N., Reischl, E., Waldenberger, M., Gieger, C., Illig, T., Kabesch, M., Zhang, X.J., Xiao, F.L., Lee, Y.A., Franke, A. and Weidinger, S.
Journal of Allergy and Clinical Immunology 136
(3): 802-806.
September 2015
Plasma fetuin-A concentration, genetic variation in the AHSG gene and risk of colorectal cancer.
Nimptsch, K., Aleksandrova, K., Boeing, H., Janke, J., Lee, Y.A., Jenab, M., Yeon Kong, S., Tsilidis, K.K., Weiderpass, E., Bueno-De-Mesquita, B.H., Siersema, P.D., Jansen, E.H.J.M., Trichopoulou, A., Tjønneland, A., Olsen, A., Wu, C., Overvad, K., Boutron-Ruault, M.C., Racine, A., Freisling, H., Katzke, V., Kaaks, R., Lagiou, P., Trichopoulos, D., Severi, G., Naccarati, A., Mattiello, A., Palli, D., Grioni, S., Tumino, R., Peeters, P.H., Ljuslinder, I., Nyström, H., Brändstedt, J., Sánchez, M.J., Barricarte Gurrea, A., Bonet Bonet, C., Chirlaque, M.D., Dorronsoro, M., Quirós, J.R., Travis, R.C., Khaw, K.T., Wareham, N., Riboli, E., Gunter, M.J. and Pischon, T.
International Journal of Cancer 137
(4): 911-920.
15 August 2015
Allergic multimorbidity of asthma, rhinitis, and eczema over 20 years in the German birth cohort MAS.
Gough, H., Grabenhenrich, L., Reich, A., Eckers, N., Nitsche, O., Schramm, D., Beschorner, J., Hoffmann, U., Schuster, A., Bauer, C.P., Forster, J., Zepp, F., Lee, Y.A., Bergmann, R.L., Bergmann, K.E., Wahn, U., Lau, S. and Keil, T.
Pediatric Allergy and Immunology 26
(5): 431-437.
August 2015
eQTL mapping identifies insertion- and deletion-specific eQTLs in multiple tissues.
Huang, J., Chen, J., Esparza, J., Ding, J., Elder, J.T., Abecasis, G.R., Lee, Y.A., Lathrop, G.M., Moffatt, M.F., Cookson, W.O.C. and Liang, L.
Nature Communications 6
: 6821.
8 May 2015
Maternal filaggrin mutations increase the risk of atopic dermatitis in children: an effect independent of mutation inheritance.
Esparza-Gordillo, J., Matanovic, A., Marenholz, I., Bauerfeind, A., Rohde, K., Nemat, K., Lee-Kirsch, M.A., Nordenskjöld, M., Winge, M.C.G., Keil, T., Krüger, R., Lau, S., Beyer, K., Kalb, B., Niggemann, B., Hübner, N., Cordell, H.J., Bradley, M. and Lee, Y.A.
PLoS Genetics 11
(3): e1005076.
10 March 2015
Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk.
Nimptsch, K., Aleksandrova, K., Boeing, H., Janke, J., Lee, Y.A., Jenab, M., Bueno-De-Mesquita, B.H., Jansen, E.H.J.M., Tsilidis, K.K., Trichopoulou, A., Weiderpass, E., Wu, C., Overvad, K., Tjønneland, A., Boutron-Ruault, M.C., Dossus, L., Racine, A., Kaaks, R., Canzian, F., Lagiou, P., Trichopoulos, D., Palli, D., Agnoli, C., Tumino, R., Vineis, P., Panico, S., Johansson, A., VanGuelpen, B., Khaw, K.T., Wareham, N., Peeters, P.H., Quirós, J.R., Venceslá García, A., Molina-Montes, E., Dorronsoro, M., Chirlaque, M.D., Gurrea, A.B., Key, T.J., Duarte-Salles, T., Stepien, M., Gunter, M.J., Riboli, E. and Pischon, T.
International Journal of Cancer 136
(5): 1181-1192.
1 March 2015
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.
Baurecht, H., Hotze, M., Brand, S., Büning, C., Cormican, P., Corvin, A., Ellinghaus, D., Ellinghaus, E., Esparza-Gordillo, J., Fölster-Holst, R., Franke, A., Gieger, C., Hubner, N., Illig, T., Irvine, A.D., Kabesch, M., Lee, Y.A.E., Lieb, W., Marenholz, I., McLean, W.H.I., Morris, D.W., Mrowietz, U., Nair, R., Nöthen, M.M., Novak, N., O'Regan, G.M., Schreiber, S., Smith, C., Strauch, K., Stuart, P.E., Trembath, R., Tsoi, L.C., Weichenthal, M., Barker, J., Elder, J.T., Weidinger, S., Cordell, H.J. and Brown, S.J.
American Journal of Human Genetics 96
(1): 104-120.
8 January 2015
Defective removal of ribonucleotides from DNA promotes systemic autoimmunity.
Günther, C., Kind, B., Reijns, M.A.M., Berndt, N., Martinez-Bueno, M., Wolf, C., Tüngler, V., Chara, O., Lee, Y.A., Hübner, N., Bicknell, L., Blum, S., Krug, C., Schmidt, F., Kretschmer, S., Koss, S., Astell, K.R., Ramantani, G., Bauerfeind, A., Morris, D.L., Cunninghame Graham, D.S., Bubeck, D., Leitch, A., Ralston, S.H., Blackburn, E.A., Gahr, M., Witte, T., Vyse, T.J., Melchers, I., Mangold, E., Nöthen, M.M., Aringer, M., Kuhn, A., Lüthke, K., Unger, L., Bley, A., Lorenzi, A., Isaacs, J.D., Alexopoulou, D., Conrad, K., Dahl, A., Roers, A., Alarcon-Riquelme, M.E., Jackson, A.P. and Lee-Kirsch, M.A.
Journal of Clinical Investigation 125
(1): 413-424.
2 January 2015
2014
Genomes and phenomes of a population of outbred rats and its progenitors.
Baud, A., Guryev, V., Hummel, O., Johannesson, M. and Flint, J.
Scientific Data 1
: 140011.
10 June 2014
Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure.
Scholtens, S., Postma, D.S., Moffatt, M.F., Panasevich, S., Granell, R., Henderson, A.J., Melen, E., Nyberg, F., Pershagen, G., Jarvis, D., Ramasamy, A., Wjst, M., Svanes, C., Bouzigon, E., Demenais, F., Kauffmann, F., Siroux, V., von Mutius, E., Ege, M.J., Braun-Fahrlaender, C., Genuneit, J., Brunekreef, B., Smit, H.A., Wijga, A.H., Kerkhof, M., Curjuric, I., Imboden, M., Thun, G.A., Probst-Hensch, N., Freidin, M.B., Bragina, E.I., Deev, I.A., Puzyrev, V.P., Daley, D., Park, J., Becker, A., Chan-Yeung, M., Kozyrskyj, A.L., Pare, P., Marenholz, I., Lau, S., Keil, T., Lee, Y.A., Kabesch, M., Wijmenga, C., Franke, L., Nolte, I.M., Vonk, J., Kumar, A., Farrall, M., Cookson, W.O.C.M., Strachan, D.P., Koppelman, G.H. and Boezen, H.M.
Journal of Allergy and Clinical Immunology 133
(3): 885-888.
March 2014
2013
Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects.
Saunders, S.P., Goh, C.S.M., Brown, S.J., Palmer, C.N.A., Porter, R.M., Cole, C., Campbell, L.E., Gierlinski, M., Barton, G.J., Schneider, G., Balmain, A., Prescott, A.R., Weidinger, S., Baurecht, H., Kabesch, M., Gieger, C., Lee, Y.A., Tavendale, R., Mukhopadhyay, S., Turner, S.W., Madhok, V.B., Sullivan, F.M., Relton, C., Burn, J., Meggitt, S., Smith, C.H., Allen, M.A., Barker, J.N.W.N., Reynolds, N.J., Cordell, H.J., Irvine, A.D., McLean, W.H.I., Sandilands, A. and Fallon, P.G.
Journal of Allergy and Clinical Immunology 132
(5): 1121-1129.
November 2013
Shared genetic determinants between eczema and other immune-related diseases.
Marenholz, I., Esparza-Gordillo, J. and Lee, Y.A.
Current Opinion in Allergy and Clinical Immunology 13
(5): 478-486.
October 2013
A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis.
Esparza-Gordillo, J., Schaarschmidt, H., Liang, L., Cookson, W., Bauerfeind, A., Lee-Kirsch, M.A., Nemat, K., Henderson, J., Paternoster, L., Harper, J.L., Mangold, E., Nothen, M.M., Rüschendorf, F., Kerscher, T., Marenholz, I., Matanovic, A., Lau, S., Keil, T., Bauer, C.P., Kurek, M., Ciechanowicz, A., Macek, M., Franke, A., Kabesch, M., Hubner, N., Abecasis, G., Weidinger, S., Moffatt, M. and Lee, Y.A.
Journal of Allergy and Clinical Immunology 132
(2): 371-377.
August 2013
Combined sequence-based and genetic mapping analysis of complex traits in outbred rats.
Baud, A., Hermsen, R., Guryev, V., Stridh, P., Graham, D., McBride, M.W., Foroud, T., Calderari, S., Diez, M., Ockinger, J., Beyeen, A.D., Gillett, A., Abdelmagid, N., Guerreiro-Cacais, A.O., Jagodic, M., Tuncel, J., Norin, U., Beattie, E., Huynh, N., Miller, W.H., Koller, D.L., Alam, I., Falak, S., Osborne-Pellegrin, M., Martinez-Membrives, E., Canete, T., Blazquez, G., Vicens-Costa, E., Mont-Cardona, C., Diaz-Moran, S., Tobena, A., Hummel, O., Zelenika, D., Saar, K., Patone, G., Bauerfeind, A., Bihoreau, M.T., Heinig, M., Lee, Y.A., Rintisch, C., Schulz, H., Wheeler, D.A., Worley, K.C., Muzny, D.M., Gibbs, R.A., Lathrop, M., Lansu, N., Toonen, P., Ruzius, F.P., de Bruijn, E., Hauser, H., Adams, D.J., Keane, T., Atanur, S.S., Aitman, T.J., Flicek, P., Malinauskas, T., Jones, E.Y., Ekman, D., Lopez-Aumatell, R., Dominiczak, A.F., Johannesson, M., Holmdahl, R., Olsson, T., Gauguier, D., Hubner, N., Fernandez-Teruel, A., Cuppen, E., Mott, R. and Flint, J.
Nature Genetics 45
(7): 767-775.
July 2013
High-density genotyping study identifies four new susceptibility loci for atopic dermatitis.
Ellinghaus, D., Baurecht, H., Esparza-Gordillo, J., Rodríguez, E., Matanovic, A., Marenholz, I., Hübner, N., Schaarschmidt, H., Novak, N., Michel, S., Maintz, L., Werfel, T., Meyer-Hoffert, U., Hotze, M., Prokisch, H., Heim, K., Herder, C., Hirota, T., Tamari, M., Kubo, M., Takahashi, A., Nakamura, Y., Tsoi, L.C., Stuart, P., Elder, J.T., Sun, L., Zuo, X., Yang, S., Zhang, X., Hoffmann, P., Nöthen, M.M., Fölster-Holst, R., Winkelmann, J., Illig, T., Boehm, B.O., Duerr, R.H., Büning, C., Brandt, S., Glas, J., McAleer, M.A., Fahy, C.M., Kabesch, M., Brown, S., McLean, W.H.I., Irvine, A.D., Schreiber, S., Lee, Y.A., Franke, A. and Weidinger, S.
Nature Genetics 45
(7): 808-812.
July 2013
Genome-wide association study of body mass index in 23 000 individuals with and without asthma.
Melén, E., Granell, R., Kogevinas, M., Strachan, D., Gonzalez, J.R., Wjst, M., Jarvis, D., Ege, M., Braun-Fahrländer, C., Genuneit, J., Horak, E., Bouzigon, E., Demenais, F., Kauffmann, F., Siroux, V., Michel, S., von Berg, A., Heinzmann, A., Kabesch, M., Probst-Hensch, N.M., Curjuric, I., Imboden, M., Rochat, T., Henderson, J., Sterne, J.A.C., McArdle, W.L., Hui, J., James, A.L., William Musk, A., Palmer, L.J., Becker, A., Kozyrskyj, A.L., Chan-Young, M., Park, J.E., Leung, A., Daley, D., Freidin, M.B., Deev, I.A., Ogorodova, L.M., Puzyrev, V.P., Celedón, J.C., Brehm, J.M., Cloutier, M.M., Canino, G., Acosta-Pérez, E., Soto-Quiros, M., Avila, L., Bergstroem, A., Magnusson, J., Söderhäll, C., Kull, I., Scholtens, S., Marike Boezen, H., Koppelman, G.H., Wijga, A.H., Marenholz, I., Esparza-Gordillo, J., Lau, S., Lee, Y.A., Standl, M., Tiesler, C.M., Flexeder, C., Heinrich, J., Myers, R.A., Ober, C., Nicolae, D.L., Farrall, M., Kumar, A., Moffatt, M.F., Cookson, W.O. and Lasky-Su, J.
Clinical and Experimental Allergy 43
(4): 463-474.
April 2013
2012
The ANO3/MUC15 locus is associated with eczema in families ascertained through asthma.
Dizier, M.H., Margaritte-Jeannin, P., Madore, A.M., Esparza-Gordillo, J., Moffatt, M.F., Corda, E., Monier, F., Guilloud-Bataille, M., Franke, A., Weidinger, S., Annesi-Maesano, I., Just, J., Pin, I., Kauffmann, F., Cookson, W., Lee, Y.A., Laprise, C., Lathrop, M., Bouzigon, E. and Demenais, F.
Journal of Allergy and Clinical Immunology 129
(6): 1547-1553.
June 2012
An Alu element-associated hypermethylation variant of the POMC gene is associated with childhood obesity.
Kuehnen, P., Mischke, M., Wiegand, S., Sers, C., Horsthemke, B., Lau, S., Keil, T., Lee, Y.A., Grueters, A. and Krude, H.
PLoS Genetics 8
(3): e1002543.
15 March 2012
Multi-locus stepwise regression: a haplotype-based algorithm for finding genetic associations applied to atopic dermatitis.
Knuppel, S., Esparza-Gordillo, J., Marenholz, I., Holzhutter, H., Bauerfeind, A., Ruether, A., Weidinger, S., Lee, Y.A. and Rohde, K.
BMC Medical Genetics 13
(1): 8.
27 January 2012
2011
Association screening in the epidermal differentiation complex (EDC) identifies an SPRR3 repeat number variant as a risk factor for eczema.
Marenholz, I., Rivera, V.A., Esparza-Gordillo, J., Bauerfeind, A., Lee-Kirsch, M.A., Ciechanowicz, A., Kurek, M., Piskackova, T., Macek, M. and Lee, Y.A.
Journal of Investigative Dermatology 131
(8): 1644-1649.
August 2011
The eczema risk variant on chromosome 11q13 (rs7927894) in the population-based ALSPAC cohort: a novel susceptibility factor for asthma and hay fever.
Marenholz, I., Bauerfeind, A., Esparza-Gordillo, J., Kerscher, T., Granell, R., Nickel, R., Lau, S., Henderson, J. and Lee, Y.A.
Human Molecular Genetics 20
(12): 2443-2449.
15 June 2011
2010
Genome-wide approaches to the etiology of eczema.
Esparza-Gordillo, J., Marenholz, I. and Lee, Y.A.
Current Opinion in Allergy and Clinical Immunology 10
(5): 418-426.
October 2010
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk.
Heinig, M., Petretto, E., Wallace, C., Bottolo, L., Rotival, M., Lu, H., Li, Y., Sarwar, R., Langley, S.R., Bauerfeind, A., Hummel, O., Lee, Y.A., Paskas, S., Rintisch, C., Saar, K., Cooper, J., Buchan, R., Gray, E.E., Cyster, J.G., Braund, P., Gracey, J., Krishnan, U., Moore, J.S., Nelson, C.P., Pollard, H., Attwood, T., Crisp-Hihn, A., Foad, N., Jolley, J., Lloyd-Jones, H., Muir, D., Murray, E., O'Leary, K., Rankin, A., Sambrook, J., Godfroy, T., Brocheton, J., Proust, C., Schmitz, G., Heimerl, S., Lugauer, I., Belz, S., Gulde, S., Linsel-Nitschke, P., Sager, H., Schroeder, L., Lundmark, P., Syvannen, A.C., Neudert, J., Scholz, M., Deloukas, P., Gray, E., Gwilliams, R., Niblett, D., Erdmann, J., Hengstenberg, C., Maouche, S., Ouwehand, W.H., Rice, C.M., Samani, N.J., Schunkert, H., Goodall, A.H., Schulz, H., Roider, H.G., Vingron, M., Blankenberg, S., Muenzel, T., Zeller, T., Szymczak, S., Ziegler, A., Tiret, L., Smyth, D.J., Pravenec, M., Aitman, T.J., Cambien, F., Clayton, D., Todd, J.A., Huebner, N. and Cook, S.A.
Nature 467
(7314): 460-464.
23 September 2010
2009
Genetik des atopischen Ekzems: Neue Gene und Pathomechanismen [The genetics of atopic eczema: New genes and pathomechanisms].
Marenholz, I. and Lee, Y.A.
Medizinische Genetik 21
(4): 493-497.
December 2009
Familial and sporadic 15q13.3 microdeletions in idiopathic generalized epilepsy: precedent for disorders with complex inheritance.
Dibbens, L.M., Mullen, S., Helbig, I., Mefford, H.C., Bayly, M.A., Bellows, S., Leu, C., Trucks, H., Obermeier, T., Wittig, M., Franke, A., Caglayan, H., Yapici, Z., Sander, T., Eichler, E.E., Scheffer, I.E., Mulley, J.C. and Berkovic, S.F.
Human Molecular Genetics 18
(19): 3626-3631.
1 October 2009
IL13 variants are associated with total serum IgE and early sensitization to food allergens in children with atopic dermatitis.
Zitnik, S.E., Rueschendorf, F., Mueller, S., Sengler, C., Lee, Y.A., Griffioen, R.W., Meglio, P., Wahn, U., Witt, H. and Nickel, R.
Pediatric Allergy and Immunology 20
(6): 551-555.
September 2009
No association between the eczema genes COL29A1 and IL31 and inflammatory bowel disease.
Zucchelli, M., Torkvist, L., Bresso, F., Halfvarson, J., Soederhaell, C., Lee, Y.A., Loefberg, R., Kere, J. and D'Amato, M.
Inflammatory Bowel Diseases 15
(7): 961-962.
July 2009
Association of filaggrin loss-of-function-mutations with atopic dermatitis and asthma in the early treatment of the atopic child (ETAC) population.
Mueller, S., Marenholz, I., Lee, Y.A., Sengler, C., Zitnik, S.E., Griffioen, R.W., Meglio, P., Wahn, U. and Nickel, R.
Pediatric Allergy and Immunology 20
(4): 358-361.
June 2009
A common variant on chromosome 11q13 is associated with atopic dermatitis.
Esparza-Gordillo, J., Weidinger, S., Foelster-Holst, R., Bauerfeind, A., Rueschendorf, F., Patone, G., Rohde, K., Marenholz, I., Schulz, F., Kerscher, T., Huebner, N., Wahn, U., Schreiber, S., Franke, A., Vogler, R., Heath, S., Baurecht, H., Novak, N., Rodriguez, E., Illig, T., Lee-Kirsch, M.A., Ciechanowicz, A., Kurek, M., Piskackova, T., Macek, M., Lee, Y.A. and Ruether, A.
Nature Genetics 41
(5): 596-601.
May 2009
ICOS-gene variants are not associated with atopic disease susceptibility in European children.
Beier, K.C., Humberdros, S., Witt, H., Illi, S., Rueschendorf, F., Nickel, R., Lee, Y.A., Lau, S., Wahn, U. and Hamelmann, E.
Pediatric Allergy and Immunology 20
(3): 242-245.
May 2009
An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma.
Marenholz, I., Kerscher, T., Bauerfeind, A., Esparza-Gordillo, J., Nickel, R., Keil, T., Lau, S., Rohde, K., Wahn, U. and Lee, Y.A.
Journal of Allergy and Clinical Immunology 123
(4): 911-916.
April 2009
2008
SNP and haplotype mapping for genetic analysis in the rat.
Saar, K., Beck, A., Bihoreau, M.T., Birney, E., Brocklebank, D., Chen, Y., Cuppen, E., Demonchy, S., Dopazo, J., Flicek, P., Foglio, M., Fujiyama, A., Gut, I.G., Gauguier, D., Guigo, R., Guryev, V., Heinig, M., Hummel, O., Jahn, N., Klages, S., Kren, V., Kube, M., Kuhl, H., Kuramoto, T., Kuroki, Y., Lechner, D., Lee, Y.A., Lopez-Bigas, N., Lathrop, G.M., Mashimo, T., Medina, I., Mott, R., Patone, G., Perrier-Cornet, J.A., Platzer, M., Pravenec, M., Reinhardt, R., Sakaki, Y., Schilhabel, M., Schulz, H., Serikawa, T., Shikhagaie, M., Tatsumoto, S., Taudien, S., Toyoda, A., Voigt, B., Zelenika, D., Zimdahl, H. and Huebner, N.
Nature Genetics 40
(5): 560-566.
May 2008
G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth.
Pasternack, S.M., von Kuegelgen, I., Aboud, K.A., Lee, Y.A., Rueschendorf, F., Voss, K., Hillmer, A.M., Molderings, G.J., Franz, T., Ramirez, A., Nuernberg, P., Noethen, M.M. and Betz, R.C.
Nature Genetics 40
(3): 329-334.
March 2008
2007
A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema.
Schulz, F., Marenholz, I., Foelster-Holst, R., Chen, C., Sternjak, A., Baumgrass, R., Esparza-Gordillo, J., Grueber, C., Nickel, R., Schreiber, S., Stoll, M., Kurek, M., Rueschendorf, F., Huebner, N., Wahn, U. and Lee, Y.A.
Journal of Allergy and Clinical Immunology 120
(5): 1097-1102.
November 2007
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.
Lee-Kirsch, M.A., Gong, M., Chowdhury, D., Senenko, L., Engel, K., Lee, Y.A., de Silva, U., Bailey, S.L., Witte, T., Vyse, T.J., Kere, J., Pfeiffer, C., Harvey, S., Wong, A., Koskenmies, S., Hummel, O., Rohde, K., Schmidt, R.E., Dominiczak, A.F., Gahr, M., Hollis, T., Perrino, F.W., Lieberman, J. and Huebner, N.
Nature Genetics 39
(9): 1065-1067.
September 2007
Variants in a novel epidermal collagen gene (COL29A1) are associated with atopic dermatitis.
Soederhaell, C., Marenholz, I., Kerscher, T., Rueschendorf, F., Esparza-Gordillo, J., Worm, M., Gruber, C., Mayr, G., Albrecht, M., Rohde, K., Schulz, H., Wahn, U., Huebner, N. and Lee, Y.A.
PLoS Biology 5
(9): e242.
September 2007
2006
S100A1-deficient male mice exhibit increased exploratory activity and reduced anxiety-related responses.
Ackermann, G.E., Marenholz, I., Wolfer, D.P., Chan, W.Y., Schaefer, B., Erne, P. and Heizmann, C.W.
Biochimica et Biophysica Acta - Molecular Cell Research 1763
(11): 1307-1319.
November 2006
Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march.
Marenholz, I., Nickel, R., Rueschendorf, F., Schulz, F., Esparza-Gordillo, J., Kerscher, T., Grueber, C., Lau, S., Worm, M., Keil, T., Kurek, M., Zaluga, E., Wahn, U. and Lee, Y.A.
Journal of Allergy and Clinical Immunology 118
(4): 866-871.
October 2006
Susceptibility loci for atopic dermatitis on chromosome 21 in a Swedish population.
Bu, L.M., Bradley, M., Soederhaell, C., Wahlgren, C.F., Kockum, I. and Nordenskjoeld, M.
Allergy 61
(5): 617-621.
May 2006
Genome-wide linkage analysis of allergic rhinoconjunctivitis in a Swedish population.
Bu, L.M., Bradley, M., Soederhaell, C., Wahlgren, C.F., Kockum, I. and Nordenskjoeld, M.
Clinical and Experimental Allergy 36
(2): 204-210.
February 2006
2005
Genomewide scan and fine-mapping linkage studies in four European samples with bipolar affective disorder suggest a new susceptibility locus on chromosome 1p35-p36 and provides further evidence of loci on chromosome 4q31 and 6q24.
Schumacher, J., Kaneva, R., Jamra, R.A., Diaz, G.O., Ohlraun, S., Milanova, V., Lee, Y.A., Rivas, F., Mayoral, F., Fuerst, R., Flaquer, A., Windemuth, C., Gay, E., Sanz, S., Gonzalez, M.J., Gil, S., Cabaleiro, F., del Rio, F., Perez, F., Haro, J., Kostov, C., Chorbov, V., Nikolova-Hill, A., Stoyanova, V., Onchev, G., Kremensky, I., Strauch, K., Schulze, T.G., Nuernberg, P., Gaebel, W., Klimke, A., Auburger, G., Wienker, T.F., Kalaydjieva, L., Propping, P., Cichon, S., Jablensky, A., Rietschel, M. and Noethen, M.M.
American Journal of Human Genetics 77
(6): 1102-1111.
1 December 2005
Phenotypic and genetic heterogeneity in a genome-wide linkage study of asthma families.
Altmüller, J., Seidel, C., Lee, Y.A., Loesgen, S., Bulle, D., Friedrichs, F., Jellouschek, H., Kelber, J., Keller, A., Schuster, A., Silbermann, M., Wahlen, W., Wolff, P., Rueschendorf, F., Schlenvoigt, G., Nuernberg, P. and Wjst, M.
BMC Pulmonary Medicine 5
: 1.
5 January 2005
Lack of association of the G protein-coupled receptor for asthma susceptibility gene with atopic dermatitis.
Soederhaell, C., Marenholz, I., Nickel, R., Grueber, C., Kehrt, R., Rohde, K., Griffioen, R.W., Meglio, P., Tarani, L., Gustafsson, D., Hoffmann, U., Gerstner, B., Mueller, S., Wahn, U. and Lee, Y.A.
Journal of Allergy and Clinical Immunology 116
(1): 220-221.
1 January 2005
2004
A SNP map of the rat genome generated from cDNA sequences.
Zimdahl, H., Nyakatura, G., Brandt, P., Schulz, H., Hummel, O., Fartmann, B., Brett, D., Droege, M., Monti, J., Lee, Y.A., Sun, Y.Y., Zhao, S.Y., Winter, E.E., Ponting, C.P., Chen, Y., Kasprzyk, A., Birney, E., Ganten, D. and Hubner, N.
Science 303
(5659): 807-807.
1 January 2004
2003
Genome-wide linkage reveals a locus for human essential (primary) hypertension on chromosome 12p.
Gong, M., Zhang, H.Y., Schulz, H., Lee, Y.A., Sun, K., Bähring, S., Luft, F.C., Nürnberg, P., Reis, A., Rohde, K., Ganten, D., Hui, R.T. and Hübner, N.
Human Molecular Genetics 12
(11): 1273-1277.
1 June 2003
2001
Mutations in CAV3 cause mechanical hyperirritability of skeletal muscle in rippling muscle disease.
Betz, R.C., Schoser, B.G.H., Kasper, D., Ricker, K., Ramirez, A., Stein, V., Torbergsen, T., Lee, Y.A., Nothen, M.M., Wienker, T.F., Malin, J.P., Propping, P., Reis, A., Mortier, W., Jentsch, T.J., Vorgerd, M. and Kubisch, C.
Nature Genetics 28
(3): 218-219.
July 2001
Localisation of a gene for an autosomal recessive syndrome of macrocephaly, multiple epiphyseal dysplasia, and distinctive facies to chromosome 15q26.
Bayoumi, R., Saar, K., Lee, Y.A., Nuernberg, G., Reis, A., Nur-E-Kamal, M. and Al Gazali, L.I.
Journal of Medical Genetics 38
(6): 369-373.
1 January 2001
2000
A major susceptibility locus for atopic dermatitis maps to chromosome 3q21.
Lee, Y.A., Wahn, U., Kehrt, R., Tarani, L., Businco, L., Gustafsson, D., Andersson, F., Oranje, A.P., Wolkertstorfer, A., von Berg, A., Hoffmann, U., Kuester, W., Wienker, T.F., Rueschendorf, F. and Reis, A.
Nature Genetics 26
: 470-473.
1 December 2000
Genomewide scan in German families reveals evidence for a novel psoriasis-susceptibility locus on chromosome 19p13.
Lee, Y.A., Rueschendorf, F., Windemuth, C., Schmitt-Egenolf, M., Stadelmann, A., Nuernberg, G., Staender, M., Wienker, T.F., Reis, A. and Traupe, H.
American Journal of Human Genetics 67
(4): 1020-1024.
1 October 2000
Localization of a gene for syndactyly type 1 to chromosome 2q34-q36.
Bosse, K., Betz, R.C., Lee, Y.A., Wienker, T.F., Reis, A., Kleen, H., Propping, P., Cichon, S. and Noethen, M.M.
American Journal of Human Genetics 67
: 492-497.
1 August 2000
A gene for hypotrichosis simplex of the scalp maps to chromosome 6p21.3.
Betz, R.C., Lee, Y.A., Bygum, A., Brandrup, F., Bernal, A.I., Toribio, J., Alvarez, J.I., Kukuk, G.M., Ibsen, H.H.W., Rasmussen, H.B., Wienker, T.F., Reis, A., Propping, P., Kruse, R., Cichon, S. and Noethen, M.M.
American Journal of Human Genetics 66
: 1979-1983.
1 June 2000
A gene for an autosomal dominant scleroatrophic syndrome predisposing to skin cancer (Huriez Syndrome) maps to chromosome 4q23.
Lee, Y.A., Stevens, H.P., Delaporte, E., Wahn, U. and Reis, A.
American Journal of Human Genetics 66
: 326-330.
1 January 2000
1999
Congenic substitution mapping excludes Sa as a candidate gene locus for a blood pressure quantitative trait locus on rat chromosome 1.
Hübner, N., Lee, Y.A., Lindpaintner, K., Ganten, D. and Kreutz, R.
Hypertension 34
: 643-648.
1 January 1999
1997
Tissue and development specific expression of multiple alternatively spliced transcripts of rat neuronal nitric oxide synthase.
Lee, M.A., Cai, L., Hübner, N., Lee, Y.A. and Lindpaintner, K.
Journal of Clinical Investigation 100
(6): 1507-1512.
15 September 1997
The stroke-prone spontaneously hypertensive rat and its role in the genetic dissection of cardiovascular disease.
Hübner, N., Lee, Y.A., Kreutz, R., Lindpaintner, K. and Ganten, D.
In:
Nutrition and Stroke.
Nestle Nutrition Workshop Series, Supplement
.
Nestec Ltd., Vevey/Lippincott-Raven Publ., Philadelphia, 87-99.
1 January 1997
1995
Genetische Analyse des Bluthochdrucks.
Lee, Y.A., Hübner, N. and Ganten, D.
In:
Jahrbuch 1995 der Deutschen Akademie der Naturforscher Leopoldina (Halle/Saale).
Leopoldina, R.3, 41
.
Dt. Akad. d. Naturforscher Leopoldina, Halle/Saale, 323-333.
1 January 1995
The gene encoding endothelial nitric oxide synthase, Nos3, maps to rat chromosome 4.
Hübner, N., Kreutz, R., Rubattu, S., Lee, Y.A., Ganten, D., Allen, P.D. and Lindpaintner, K.
Mammalian Genome 6
(10): 758-759.
1 January 1995
This list was generated on Tue Oct 8 12:49:05 2024 UTC.