2026

AKAP signaling: physiological and pathophysiological role and opportunities for novel therapeutic concepts.
Herberg, Friedrich W. ORCID: https://orcid.org/0000-0001-7117-7653, Paolocci, Ester ORCID: https://orcid.org/0009-0002-2045-0810 and Klussmann, Enno ORCID: https://orcid.org/0000-0003-4004-5003
Physiological Reviews 106 (4): 2189-2266. October 2026

Synthesis and characterization of cortinarins - cryptic cyclic peptides from mushrooms of the genus Cortinarius.
He, Zhanyu ORCID: https://orcid.org/0009-0009-9516-1862, Janssen, Celine ORCID: https://orcid.org/0009-0000-4362-388X, Schäfer, Joana-Lysiane ORCID: https://orcid.org/0009-0007-2780-3769, Mühlenweg, Agnes, Kosol, Simone ORCID: https://orcid.org/0000-0001-7913-4818, Jarling, Rene, Mainz, Andi ORCID: https://orcid.org/0000-0003-3428-864X, Keller, Bettina G. ORCID: https://orcid.org/0000-0002-7051-0888, Yao, Guiyang ORCID: https://orcid.org/0000-0001-5730-7597, Klussmann, Enno ORCID: https://orcid.org/0000-0003-4004-5003 and Süssmuth, Roderich D. ORCID: https://orcid.org/0000-0001-7027-2069
Chemical Science 23 June 2026 (In Press)

Prevascularized grafts with spatially organized MSC spheroids to accelerate therapeutic angiogenesis in ischemic disease.
Son, Jeonghyun, Naren, Aruzhan ORCID: https://orcid.org/0000-0003-0373-7131, Mohamed, Hanan Jamal, Ahn, Minjun, Ha, Won, Kim, Min Kyeong, Jeon, Seunggyu, Kim, Byoung Soo, Cho, Yoon-Kyoung, Takeuchi, Shoji and Kang, Hyun-Wook
Angiogenesis 29 (3): 38. 9 June 2026

2025

Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels.
Handklo-Jamal, Reem ORCID: https://orcid.org/0000-0001-6237-5412, Raifman, Tal Keren, Shalomov, Boris ORCID: https://orcid.org/0000-0002-1322-4906, Hofer, Patrick ORCID: https://orcid.org/0009-0004-5778-9599, Kahanovitch, Uri, Friesacher, Theres ORCID: https://orcid.org/0000-0001-5632-3472, Tabak, Galit, Tsemakhovich, Vladimir, Reddy, Haritha P., Chomsky-Hecht, Orna, Tripathy, Debi Ranjan, Zuhlke, Kerstin, Dessauer, Carmen W., Klussmann, Enno ORCID: https://orcid.org/0000-0003-4004-5003, Haitin, Yoni ORCID: https://orcid.org/0000-0002-1648-6792, Hirsch, Joel A. ORCID: https://orcid.org/0000-0001-7544-8668, Stary-Weinzinger, Anna ORCID: https://orcid.org/0000-0002-9202-0484, Yakubovich, Daniel ORCID: https://orcid.org/0000-0003-2871-1026 and Dascal, Nathan ORCID: https://orcid.org/0000-0002-5397-4146
Nature Communications 16 (1): 11607. 29 December 2025

Activated CaMKIIδ translocates to the RyR nanodomain in cardiomyocytes.
Bergan-Dahl, Anna ORCID: https://orcid.org/0000-0003-1145-596X, Carlson, Cathrine R., Laasmaa, Martin, Subramanian, Hariharan, Basson, Adelle, Li, Jia, Hasic, Almira, Lunde, Marianne, Ugland, Hege, Manfra, Ornella ORCID: https://orcid.org/0000-0002-3802-6690, Klussmann, Enno ORCID: https://orcid.org/0000-0003-4004-5003, Bossuyt, Julie, Bers, Donald M. ORCID: https://orcid.org/0000-0002-2237-9483, Nikolaev, Viacheslav O., Louch, William E. ORCID: https://orcid.org/0000-0002-0511-6112 and Shen, Xin
Cardiovascular Research 121 (14): 2177-2188. October 2025

PDE3A as therapeutic target for modulation of compartmentalised cyclic nucleotide-dependent signalling.
Pati, S.R. ORCID: https://orcid.org/0000-0003-0906-6658, Sholokh, A. ORCID: https://orcid.org/0000-0002-1263-2078 and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Cells 14 (11): 771. 1 June 2025

2024

Tripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca(2+) channel may modulate its β-adrenergic regulation.
Oz, S., Keren-Raifman, T., Sharon, T., Subramaniam, S., Pallien, T., Katz, M., Tsemakhovich, V., Sholokh, A. ORCID: https://orcid.org/0000-0002-1263-2078, Watad, B., Tripathy, D.R., Sasson, G., Chomsky-Hecht, O., Vysochek, L., Schulz-Christian, M., Fecher-Trost, C., Zühlke, K., Bertinetti, D., Herberg, F.W., Flockerzi, V., Hirsch, J.A., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Weiss, S. and Dascal, N. ORCID: https://orcid.org/0000-0002-5397-4146
BMC Biology 22 (1): 276. 28 November 2024

2023

Mutant phosphodiesterase 3A protects the kidney from hypertension-induced damage.
Sholokh, A. ORCID: https://orcid.org/0000-0002-1263-2078, Walter, S., Markó, L. ORCID: https://orcid.org/0000-0003-1888-5575, McMurray, B.J., Sunaga-Franze, D.Y. ORCID: https://orcid.org/0000-0002-6851-9162, Xu, M., Zühlke, K., Russwurm, M., Bartolomaeus, T.U.P. ORCID: https://orcid.org/0000-0002-5156-7184, Langanki, R., Qadri, F. ORCID: https://orcid.org/0000-0002-8500-489X, Heuser, A. ORCID: https://orcid.org/0000-0002-3334-960X, Patzak, A., Forslund, S.K. ORCID: https://orcid.org/0000-0003-4285-6993, Bähring, S. ORCID: https://orcid.org/0000-0001-8734-9755, Borodina, T. ORCID: https://orcid.org/0000-0002-6978-016X, Persson, P.B., Maass, P.G. ORCID: https://orcid.org/0000-0002-2742-8301, Bader, M. ORCID: https://orcid.org/0000-0003-4780-4164 and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Kidney International 104 (2): 388-393. August 2023

Targeting cAMP signaling compartments in iPSC-derived models of cardiovascular disease.
Liu, T. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Current Opinion in Pharmacology 71 : 102392. August 2023

Many kinases for controlling the water channel aquaporin‐2.
Kharin, A. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Journal of Physiology 602 (13): 3025-3039. 1 July 2023

Mutations in phosphodiesterase 3A (PDE3A) cause hypertension without cardiac damage.
Ercu, M., Walter, S. ORCID: https://orcid.org/0000-0002-2041-2921 and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Hypertension 80 (6): 1171-1179. June 2023

Integrated proteomics unveils nuclear PDE3A2 as a regulator of cardiac myocyte hypertrophy.
Subramaniam, G., Schleicher, K., Kovanich, D. ORCID: https://orcid.org/0000-0001-5974-829X, Zerio, A., Folkmanaite, M. ORCID: https://orcid.org/0000-0003-0469-8787, Chao, Y.C. ORCID: https://orcid.org/0000-0001-5946-6196, Surdo, N.C., Koschinski, A., Hu, J. ORCID: https://orcid.org/0000-0003-1384-7465, Scholten, A., Heck, A.J.R ORCID: https://orcid.org/0000-0002-2405-4404, Ercu, M., Sholokh, A. ORCID: https://orcid.org/0000-0002-1263-2078, Chan Park, K. ORCID: https://orcid.org/0000-0001-7203-0127, Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Meraviglia, V. ORCID: https://orcid.org/0000-0002-9571-0309, Bellin, M. ORCID: https://orcid.org/0000-0001-5380-6743, Zanivan, S., Hester, S., Mohammed, S. and Zaccolo, M. ORCID: https://orcid.org/0000-0002-0934-3662
Circulation Research 132 (7): 828-848. 31 March 2023

Aquaporin-2 is not alone.
Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Kidney International 103 (3): 458-460. March 2023

2022

Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage.
Ercu, M., Mücke, M.B. ORCID: https://orcid.org/0000-0002-4957-3307, Pallien, T., Markó, L. ORCID: https://orcid.org/0000-0003-1888-5575, Sholokh, A. ORCID: https://orcid.org/0000-0002-1263-2078, Schächterle, C., Aydin, A. ORCID: https://orcid.org/0000-0002-2890-0225, Kidd, A., Walter, S. ORCID: https://orcid.org/0000-0002-2041-2921, Esmati, Y. ORCID: https://orcid.org/0000-0001-9010-8119, McMurray, B.J. ORCID: https://orcid.org/0000-0003-3394-0667, Lato, D.F. ORCID: https://orcid.org/0000-0002-9263-8532, Sunaga-Franze, D.Y. ORCID: https://orcid.org/0000-0002-6851-9162, Dierks, P.H. ORCID: https://orcid.org/0000-0001-5903-8343, Flores, B.I.M., Walker-Gray, R., Gong, M. ORCID: https://orcid.org/0000-0001-7384-3429, Merticariu, C., Zühlke, K., Russwurm, M., Liu, T., Batolomaeus, T.U.P. ORCID: https://orcid.org/0000-0002-5156-7184, Pautz, S., Schelenz, S., Taube, M., Napieczynska, H. ORCID: https://orcid.org/0000-0001-5091-1185, Heuser, A. ORCID: https://orcid.org/0000-0002-3334-960X, Eichhorst, J., Lehmann, M., Miller, D.C. ORCID: https://orcid.org/0000-0001-9852-677X, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Qadri, F. ORCID: https://orcid.org/0000-0002-8500-489X, Popova, E. ORCID: https://orcid.org/0000-0002-3043-9650, Langanki, R., Movsesian, M.A., Herberg, F.W. ORCID: https://orcid.org/0000-0001-7117-7653, Forslund, S.K. ORCID: https://orcid.org/0000-0003-4285-6993, Müller, D.N. ORCID: https://orcid.org/0000-0003-3650-5644, Borodina, T. ORCID: https://orcid.org/0000-0002-6978-016X, Maass, P.G. ORCID: https://orcid.org/0000-0002-2742-8301, Bähring, S. ORCID: https://orcid.org/0000-0001-8734-9755, Hübner, N. ORCID: https://orcid.org/0000-0002-1218-6223, Bader, M. ORCID: https://orcid.org/0000-0003-4780-4164 and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Circulation 146 (23): 1758-1778. 6 December 2022

A novel AQP2 sequence variant causing aquaporin-2 retention in the cytoplasm and autosomal dominant nephrogenic diabetes insipidus.
Hinrichs, G.R., Baltzer, S. ORCID: https://orcid.org/0000-0002-9104-7060, Pallien, T., Svenningsen, P., Dalgaard, E.B., Hertz, J.M., Bistrup, C., Jensen, B.L. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Kidney International Reports 7 (10): 2289-2294. October 2022

Aurora kinase A is involved in controlling the localization of aquaporin-2 in renal principal cells.
Baltzer, S. ORCID: https://orcid.org/0000-0002-9104-7060, Bulatov, T., Schmied, C., Krämer, A., Berger, B.T. ORCID: https://orcid.org/0000-0002-3314-2617, Oder, A., Walker-Gray, R., Kuschke, C., Zühlke, K., Eichhorst, J., Lehmann, M. ORCID: https://orcid.org/0000-0002-8370-6353, Knapp, S. ORCID: https://orcid.org/0000-0001-5995-6494, Weston, J., von Kries, J.P. ORCID: https://orcid.org/0000-0003-4716-4988, Süssmuth, R.D. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
International Journal of Molecular Sciences 23 (2): 763. 11 January 2022

AKAP18δ anchors and regulates CaMKII activity at phospholamban-SERCA2 and RYR.
Carlson, C.R. ORCID: https://orcid.org/0000-0001-6360-3149, Aronsen, J.M., Bergan-Dahl, A. ORCID: https://orcid.org/0000-0003-1145-596X, Moutty, M.C., Lunde, M., Lunde, P.K., Jarstadmarken, H., Wanichawan, P., Pereira, L., Kolstad, T.R.S. ORCID: https://orcid.org/0000-0002-0589-5689, Dalhus, B. ORCID: https://orcid.org/0000-0002-9867-8391, Subramanian, H., Hille, S., Christensen, G., Müller, O.J. ORCID: https://orcid.org/0000-0001-8223-2638, Nikolaev, V. ORCID: https://orcid.org/0000-0002-7529-5179, Bers, D.M. ORCID: https://orcid.org/0000-0002-2237-9483, Sjaastad, I., Shen, X., Louch, W.E. ORCID: https://orcid.org/0000-0002-0511-6112, Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003 and Sejersted, O.M. ORCID: https://orcid.org/0000-0001-8817-3296
Circulation Research 130 (1): 27-44. 7 January 2022

Disruptors of AKAP-dependent protein-protein interactions.
Walker-Gray, R., Pallien, T., Miller, D.C. ORCID: https://orcid.org/0000-0001-9852-677X, Oder, A., Neuenschwander, M. ORCID: https://orcid.org/0000-0002-3114-7975, von Kries, J.P. ORCID: https://orcid.org/0000-0003-4716-4988, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992 and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Methods in Molecular Biology 2483 : 117-139. 2022

2021

Reconstitution of β-adrenergic regulation of Ca(V)1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.
Katz, M. ORCID: https://orcid.org/0000-0002-0327-3026, Subramaniam, S. ORCID: https://orcid.org/0000-0001-9574-2100, Chomsky-Hecht, O., Tsemakhovich, V. ORCID: https://orcid.org/0000-0002-4969-6497, Flockerzi, V., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Hirsch, J.A. ORCID: https://orcid.org/0000-0001-7544-8668, Weiss, S. ORCID: https://orcid.org/0000-0002-0981-6917 and Dascal, N. ORCID: https://orcid.org/0000-0002-5397-4146
Proceedings of the National Academy of Sciences of the United States of America 118 (21): e2100021118. 17 May 2021

Local cyclic adenosine monophosphate signalling cascades - roles and targets in chronic kidney disease.
Sholokh, A. ORCID: https://orcid.org/0000-0002-1263-2078 and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Acta Physiologica 232 (1): e13641. May 2021

Vasopressin-vermittelte Wasserrückresorption im Sammelrohr der Niere [Vasopressin-mediated water reabsorption in the renal collecting duct].
Baltzer, S. ORCID: https://orcid.org/0000-0002-9104-7060 and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
BIOspektrum 27 (2): 165-167. March 2021

Improving target assessment in biomedical research: the GOT-IT recommendations.
Emmerich, C.H. ORCID: https://orcid.org/0000-0002-7594-3973, Gamboa, L.M., Hofmann, M.C.J., Bonin-Andresen, M., Arbach, O., Schendel, P., Gerlach, B. ORCID: https://orcid.org/0000-0002-4900-6302, Hempel, K., Bespalov, A. ORCID: https://orcid.org/0000-0003-3730-1395, Dirnagl, U. ORCID: https://orcid.org/0000-0003-0755-6119 and Parnham, M.J. ORCID: https://orcid.org/0000-0002-7098-8451
Nature Reviews Drug Discovery 20 (1): 64-81. January 2021

A-kinase anchoring proteins (AKAPs).
Walker-Gray, R. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
In: Encyclopedia of Molecular Pharmacology : Third Edition. Springer, Cham, 78-83. ISBN 978-3-030-57400-0 2021

2020

Phosphodiesterase 3A and arterial hypertension.
Ercu, M., Markó, L. ORCID: https://orcid.org/0000-0003-1888-5575, Schächterle, C., Tsvetkov, D. ORCID: https://orcid.org/0000-0002-6472-971X, Cui, Y., Maghsodi, S., Bartolomaeus, T.U.P. ORCID: https://orcid.org/0000-0002-5156-7184, Maass, P.G. ORCID: https://orcid.org/0000-0002-2742-8301, Zühlke, K., Gregersen, N., Hübner, N. ORCID: https://orcid.org/0000-0002-1218-6223, Hodge, R., Mühl, A., Pohl, B., Molé-Illas, R., Geelhaar, A., Walter, S., Napieczynska, H. ORCID: https://orcid.org/0000-0001-5091-1185, Schelenz, S., Taube, M., Heuser, A. ORCID: https://orcid.org/0000-0002-3334-960X, Anistan, Y.M., Qadri, F. ORCID: https://orcid.org/0000-0002-8500-489X, Todiras, M. ORCID: https://orcid.org/0000-0002-9373-4753, Plehm, R., Popova, E. ORCID: https://orcid.org/0000-0002-3043-9650, Langanki, R., Eichhorst, J., Lehmann, M., Wiesner, B., Russwurm, M., Forslund, S.K. ORCID: https://orcid.org/0000-0003-4285-6993, Kamer, I., Müller, D.N. ORCID: https://orcid.org/0000-0003-3650-5644, Gollasch, M. ORCID: https://orcid.org/0000-0003-2797-1934, Aydin, A. ORCID: https://orcid.org/0000-0002-2890-0225, Bähring, S. ORCID: https://orcid.org/0000-0001-8734-9755, Bader, M. ORCID: https://orcid.org/0000-0003-4780-4164, Luft, F.C. ORCID: https://orcid.org/0000-0002-8635-1199 and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Circulation 142 (2): 133-149. 14 July 2020

Cyclin-dependent kinase 18 controls trafficking of aquaporin-2 and its abundance through ubiquitin ligase STUB1, which functions as an AKAP.
Dema, A., Faust, D., Lazarow, K., Wippich, M., Neuenschwander, M. ORCID: https://orcid.org/0000-0002-3114-7975, Zühlke, K., Geelhaar, A., Pallien, T., Hallscheidt, E., Eichhorst, J., Wiesner, B., Cernecká, H., Popp, O. ORCID: https://orcid.org/0000-0001-6240-4666, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Dittmar, G. ORCID: https://orcid.org/0000-0003-3647-8623, von Kries, J.P. ORCID: https://orcid.org/0000-0003-4716-4988 and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Cells 9 (3): 673. 10 March 2020

New aspects in cardiac L-type Ca(2+) channel regulation.
Pallien, T. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Biochemical Society Transactions 48 (1): 39-49. February 2020

The role of AKAP12 in coordination of VEGF-induced endothelial cell motility.
Walker-Gray, R. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Acta Physiologica 228 (1): e13359. January 2020

A-kinase anchoring proteins (AKAPs).
Walker-Gray, R. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
In: Encyclopedia of Molecular Pharmacology. Springer, Cham, 1-7. ISBN 978-3-030-21573-6 2020

2019

Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1.
Zhao, X., Nedvetsky, P., Stanchi, F. ORCID: https://orcid.org/0000-0003-3393-2472, Vion, A.C. ORCID: https://orcid.org/0000-0002-2788-2512, Popp, O. ORCID: https://orcid.org/0000-0001-6240-4666, Zühlke, K., Dittmar, G. ORCID: https://orcid.org/0000-0003-3647-8623, Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003 and Gerhardt, H. ORCID: https://orcid.org/0000-0002-3030-0384
eLife 8 : e46380. 3 October 2019

Small molecules for modulating the localisation of the water channel aquaporin-2-disease relevance and perspectives for targeting local cAMP signalling.
Baltzer, S. ORCID: https://orcid.org/0000-0002-9104-7060 and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Naunyn-Schmiedeberg's Archives of Pharmacology 392 (9): 1049-1064. September 2019

Wnt11/Fzd7 signaling compartmentalizes AKAP2/PKA to regulate L-type Ca(2+) channel.
Csalyi, K.D. ORCID: https://orcid.org/0000-0002-0853-8257, Rharass, T. ORCID: https://orcid.org/0000-0001-9406-1776, Schulz, M., Phan, M.H.Q., Wakula, P., Mhatre, K.N., Plotnick, D., Werdich, A.A., Zauber, H. ORCID: https://orcid.org/0000-0003-2595-1147, Sury, M.D., Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751, Heinzel, F.R., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003 and Panakova, D. ORCID: https://orcid.org/0000-0002-8739-6225
bioRxiv : 741637. 20 August 2019

Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases.
Omar, F., Findlay, J.E., Carfray, G., Allcock, R.W., Jiang, Z., Moore, C., Muir, A.L., Lannoy, M., Fertig, B.A., Mai, D., Day, J.P., Bolger, G., Baillie, G.S. ORCID: https://orcid.org/0000-0003-2469-6316, Schwiebert, E., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Pyne, N.J., Ong, A.C.M. ORCID: https://orcid.org/0000-0002-7211-5400, Bowers, K., Adam, J.M., Adams, D.R., Houslay, M.D. and Henderson, D.J.P.
Proceedings of the National Academy of Sciences of the United States of America 116 (27): 13320-13329. 2 July 2019

Fluconazole increases osmotic water transport in renal collecting duct through effects on aquaporin-2 trafficking.
Vukićević, T., Hinze, C. ORCID: https://orcid.org/0000-0003-2526-1621, Baltzer, S. ORCID: https://orcid.org/0000-0002-9104-7060, Himmerkus, N., Quintanova, C., Zühlke, K., Compton, F., Ahlborn, R., Dema, A., Eichhorst, J., Wiesner, B., Bleich, M., Schmidt-Ott, K.M. ORCID: https://orcid.org/0000-0002-7700-7142 and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Journal of the American Society of Nephrology 30 (5): 795-810. May 2019

Anoctamin-4 is a bona fide Ca(2+)-dependent non-selective cation channel.
Reichhart, N., Schöberl, S., Keckeis, S., Alfaar, A.S. ORCID: https://orcid.org/0000-0002-0930-4583, Roubeix, C., Cordes, M., Crespo-Garcia, S., Haeckel, A., Kociok, N. ORCID: https://orcid.org/0000-0003-4898-6035, Föckler, R., Fels, G., Mataruga, A., Rauh, R. ORCID: https://orcid.org/0000-0002-9406-3939, Milenkovic, V.M., Zühlke, K., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Schellenberger, E. and Strauß, O.
Scientific Reports 9 (1): 2257. 19 February 2019

2018

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis.
Campa, C.C., Silva, R.L., Margaria, J.P., Pirali, T. ORCID: https://orcid.org/0000-0003-3936-4787, Mattos, M.S., Kraemer, L.R., Reis, D.C., Grosa, G., Copperi, F., Dalmarco, E.M., Lima-Júnior, R.C.P., Aprile, S., Sala, V. ORCID: https://orcid.org/0000-0002-2283-2807, Dal Bello, F. ORCID: https://orcid.org/0000-0003-0726-3025, Prado, D.S., Alves-Filho, J.C. ORCID: https://orcid.org/0000-0002-9918-8714, Medana, C., Cassali, G.D., Tron, G.C., Teixeira, M.M., Ciraolo, E. ORCID: https://orcid.org/0000-0002-5601-1695, Russo, R.C. and Hirsch, E. ORCID: https://orcid.org/0000-0002-9073-6024
Nature Communications 9 (1): 5232. 12 December 2018

Roles of A-kinase anchoring proteins and phosphodiesterases in the cardiovascular system.
Ercu, M. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Journal of Cardiovascular Development and Disease 5 (1): 14. 20 February 2018

An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.
Schrade, K., Tröger, J., Eldahshan, A., Zühlke, K., Abdul Azeez, K.R., Elkins, J.M., Neuenschwander, M. ORCID: https://orcid.org/0000-0002-3114-7975, Oder, A., Elkewedi, M. ORCID: https://orcid.org/0000-0001-7958-8246, Jaksch, S., Andrae, K., Li, J., Fernandes, J., Müller, P.M. ORCID: https://orcid.org/0000-0001-9056-4114, Grunwald, S. ORCID: https://orcid.org/0000-0003-3978-6277, Marino, S.F. ORCID: https://orcid.org/0000-0001-5696-9679, Vukićević, T., Eichhorst, J., Wiesner, B., Weber, M., Kapiloff, M., Rocks, O. ORCID: https://orcid.org/0000-0001-6349-9193, Daumke, O. ORCID: https://orcid.org/0000-0002-6190-1414, Wieland, T., Knapp, S., von Kries, J.P. ORCID: https://orcid.org/0000-0003-4716-4988 and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
PLoS ONE 13 (1): e0191423. 26 January 2018

2017

Protein kinase C enhances plasma membrane expression of cardiac L-type calcium channel, Ca(V)1.2.
Raifman, T.K., Kumar, P., Haase, H., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Dascal, N. ORCID: https://orcid.org/0000-0002-5397-4146 and Weiss, S.
Channels 11 (6): 604-615. 2 November 2017

Pharmacological approaches for delineating functions of AKAP- based signalling complexes and finding therapeutic targets.
Schrade, K. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
In: Microdomains in the Cardiovascular System. Cardiac and Vascular Biology . Springer, Cham, Switzerland, 59-83. ISBN 978-3-319-54578-3 20 September 2017

Protein kinase A regulates C-terminally truncated Ca(V) 1.2 in Xenopus oocytes: roles of N- and C-termini of the α(1C) subunit.
Oz, S., Pankonien, I. ORCID: https://orcid.org/0000-0002-4622-7521, Belkacemi, A., Flockerzi, V., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Haase, H. and Dascal, N.
Journal of Physiology 595 (10): 3181-3202. 15 May 2017

2016

Bimodal antagonism of PKA signalling by ARHGAP36.
Eccles, R.L. ORCID: https://orcid.org/0000-0002-8209-5650, Czajkowski, M.T. ORCID: https://orcid.org/0000-0002-0122-1943, Barth, C., Müller, P.M. ORCID: https://orcid.org/0000-0001-9056-4114, McShane, E. ORCID: https://orcid.org/0000-0002-7806-2063, Grunwald, S. ORCID: https://orcid.org/0000-0003-3978-6277, Beaudette, P., Mecklenburg, N., Volkmer, R., Zühlke, K., Dittmar, G. ORCID: https://orcid.org/0000-0003-3647-8623, Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751, Hammes, A. ORCID: https://orcid.org/0000-0003-1663-8378, Daumke, O. ORCID: https://orcid.org/0000-0002-6190-1414, Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Urbé, S. and Rocks, O. ORCID: https://orcid.org/0000-0001-6349-9193
Nature Communications 7 : 12963. 7 October 2016

The Case : a handful of hypertension.
van den Born, B.J.H., Oskam, L.C., Zidane, M., Schaechterle, C., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Bähring, S. ORCID: https://orcid.org/0000-0001-8734-9755 and Luft, F.C. ORCID: https://orcid.org/0000-0002-8635-1199
Kidney International 90 (4): 911-913. October 2016

The A-kinase anchoring protein (AKAP) glycogen synthase kinase 3β interaction protein (GSKIP) regulates β-catenin through its interactions with both protein kinase A (PKA) and GSK3β.
Dema, A., Schröter, M.F., Perets, E., Skroblin, P. ORCID: https://orcid.org/0000-0003-0321-3493, Moutty, M.C., Deàk, V.A., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Journal of Biological Chemistry 291 (37): 19618-19630. 9 September 2016

Pharmacological interference with protein-protein interactions of A-kinase anchoring proteins as a strategy for the treatment of disease.
Deák, V.A. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Current Drug Targets 17 (10): 1147-1171. 1 August 2016

Protein-protein interactions of PDE4 family members - Functions, interactions and therapeutic value.
Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Cellular Signalling 28 (7): 713-718. July 2016

AKAP18:PKA-RIIα structure reveals crucial anchor points for recognition of regulatory subunits of PKA.
Götz, F., Roske, Y. ORCID: https://orcid.org/0000-0001-6237-388X, Schulz, M.S., Autenrieth, K., Bertinetti, D., Faelber, K., Zühlke, K., Kreuchwig, A., Kennedy, E., Krause, G., Daumke, O. ORCID: https://orcid.org/0000-0002-6190-1414, Herberg, F.W., Heinemann, U. ORCID: https://orcid.org/0000-0002-8191-3850 and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Biochemical Journal 473 (13): 1881-1894. 28 June 2016

The trafficking of the water channel aquaporin-2 in renal principal cells-a potential target for pharmacological intervention in cardiovascular diseases.
Vukićević, T., Schulz, M., Faust, D. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Frontiers in Pharmacology 7 : 23. 11 February 2016

The A-kinase anchoring protein GSKIP regulates GSK3β activity and controls palatal shelf fusion in mice.
Deák, V.A., Skroblin, P. ORCID: https://orcid.org/0000-0003-0321-3493, Dittmayer, C., Knobeloch, K.P., Bachmann, S. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Journal of Biological Chemistry 291 (2): 681-690. 8 January 2016

2015

Pharmacological targeting of AKAP-directed compartmentalized cAMP signalling.
Dema, A., Perets, E., Schulz, M.S., Deák, V.A. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Cellular Signalling 27 (12): 2474-2487. December 2015

Clinical effects of phosphodiesterase 3A mutations in inherited hypertension with brachydactyly.
Toka, O., Tank, J., Schächterle, C., Aydin, A. ORCID: https://orcid.org/0000-0002-2890-0225, Maass, P.G. ORCID: https://orcid.org/0000-0002-2742-8301, Elitok, S., Bartels-Klein, E., Hollfinger, I. ORCID: https://orcid.org/0000-0002-6233-8395, Lindschau, C. ORCID: https://orcid.org/0000-0003-1960-099X, Mai, K., Boschmann, M. ORCID: https://orcid.org/0000-0002-0114-7114, Rahn, G., Movsesian, M.A., Müller, T., Doescher, A., Gnoth, S., Mühl, A., Toka, H.R., Wefeld-Neuenfeld, Y., Utz, W., Töpper, A., Jordan, J. ORCID: https://orcid.org/0000-0003-4518-0706, Schulz-Menger, J. ORCID: https://orcid.org/0000-0003-3100-1092, Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Bähring, S. ORCID: https://orcid.org/0000-0001-8734-9755 and Luft, F.C. ORCID: https://orcid.org/0000-0002-8635-1199
Hypertension 66 (4): 800-808. October 2015

Neurochondrin is an atypical RIIα-specific A-kinase anchoring protein.
Hermann, J.S., Skroblin, P. ORCID: https://orcid.org/0000-0003-0321-3493, Bertinetti, D., Hanold, L.E., von der Heide, E.K., Wagener, E.M., Zenn, H.M., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Kennedy, E.J. and Herberg, F.W.
Biochimica et Biophysica Acta - Proteins and Proteomics 1854 (10 Pt B): 1667-1675. October 2015

PDE3A mutations cause autosomal dominant hypertension with brachydactyly.
Maass, P.G. ORCID: https://orcid.org/0000-0002-2742-8301, Aydin, A. ORCID: https://orcid.org/0000-0002-2890-0225, Luft, F.C. ORCID: https://orcid.org/0000-0002-8635-1199, Schächterle, C., Weise, A., Stricker, S., Lindschau, C. ORCID: https://orcid.org/0000-0003-1960-099X, Vaegler, M., Qadri, F. ORCID: https://orcid.org/0000-0002-8500-489X, Toka, H.R., Schulz, H. ORCID: https://orcid.org/0000-0002-0226-964X, Krawitz, P.M. ORCID: https://orcid.org/0000-0002-3194-8625, Parkhomchuk, D., Hecht, J., Hollfinger, I. ORCID: https://orcid.org/0000-0002-6233-8395, Wefeld-Neuenfeld, Y., Bartels-Klein, E., Mühl, A., Kann, M., Schuster, H., Chitayat, D., Bialer, M.G., Wienker, T.F., Ott, J., Rittscher, K., Liehr, T., Jordan, J. ORCID: https://orcid.org/0000-0003-4518-0706, Plessis, G., Tank, J., Mai, K., Naraghi, R., Hodge, R., Hopp, M., Hattenbach, L.O., Busjahn, A., Rauch, A., Vandeput, F., Gong, M. ORCID: https://orcid.org/0000-0001-7384-3429, Rüschendorf, F. ORCID: https://orcid.org/0000-0001-5640-810X, Hübner, N. ORCID: https://orcid.org/0000-0002-1218-6223, Haller, H., Mundlos, S., Bilginturan, N., Movsesian, M.A., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Toka, O. and Bähring, S. ORCID: https://orcid.org/0000-0001-8734-9755
Nature Genetics 47 (6): 647-653. June 2015

A-kinase anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle.
Poppinga, W.J. ORCID: https://orcid.org/0000-0002-2711-2411, Heijink, I.H., Holtzer, L.J., Skroblin, P. ORCID: https://orcid.org/0000-0003-0321-3493, Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Halayko, A.J., Timens, W., Maarsingh, H. and Schmidt, M.
American Journal of Physiology Lung Cellular and Molecular Physiology 308 (8): L766-L775. 15 April 2015

Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains.
Bolger, G.B., Dunlop, A.J., Meng, D., Day, J.P., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Baillie, G.S., Adams, D.R. and Houslay, M.D.
Cellular Signalling 27 (4): 756-769. April 2015

Regulation of sarcoplasmic reticulum Ca(2+) ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2.
Ahmad, F., Shen, W., Vandeput, F., Szabo-Fresnais, N., Krall, J., Degerman, E., Goetz, F., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Movsesian, M. and Manganiello, V.
Journal of Biological Chemistry 290 (11): 6763-6776. 13 March 2015

Screening for small molecule disruptors of AKAP-PKA interactions.
Schächterle, C., Christian, F., Fernandes, J.M.P. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Methods in Molecular Biology 1294 : 151-166. 2 March 2015

Keeping those telomeres short! an innovative intratumoral long-term drug delivery system.
Laster, B.H., Isaacson, C., Perets, E., Msamra, M., Priel, E., Kalef-Ezra, J. and Kost, J.
Journal of Cancer Research and Clinical Oncology 141 (1): 23-34. January 2015

2014

The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex.
Abdul Azeez, K.R., Knapp, S., Fernandes, J.M.P., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003 and Elkins, J.M.
Biochemical Journal 464 (2): 231-239. 1 December 2014

Flexible, polymer-supported synthesis of sphingosine derivatives provides ceramides with enhanced biological activity.
El-Dahshan, A., Al-Gharabli, S.I., Radetzki, S. ORCID: https://orcid.org/0000-0003-2688-2868, Al-Tel, T.H., Kumar, P. and Rademann, J. ORCID: https://orcid.org/0000-0001-6678-3165
Bioorganic and Medicinal Chemistry 22 (19): 5506-5512. 1 October 2014

G protein-coupled estrogen receptor 1 (GPER) mediates relaxation of coronary arteries via cAMP/PKA-dependent activation of MLCP.
Yu, X., Li, F., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Stallone, J.N. and Han, G.
American Journal of Physiology Endocrinology and Metabolism 307 (4): E398-E407. 15 August 2014

2013

Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.
Schäfer, G., Milić, J, Eldahshan, A, Götz, F., Zühlke, K., Schillinger, C., Kreuchwig, A., Elkins, J.M., Abdul Azeez, K.R.A., Oder, A., Moutty, M.C., Masada, N., Beerbaum, M., Schlegel, B., Niquet, S., Schmieder, P. ORCID: https://orcid.org/0000-0001-9968-9327, Krause, G., von Kries, J.P. ORCID: https://orcid.org/0000-0003-4716-4988, Cooper, D.M.F., Knapp, S., Rademann, J. ORCID: https://orcid.org/0000-0001-6678-3165, Rosenthal, W. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Angewandte Chemie International Edition 52 (46): 12187-12191. 11 November 2013

AKAPS act in a two-step mechanism of memory acquisition.
Scheunemann, L., Skroblin, P. ORCID: https://orcid.org/0000-0003-0321-3493, Hundsrucker, C., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Efetova, M. and Schwärzel, M.
Journal of Neuroscience 33 (44): 17422-17428. 30 October 2013

Culturing primary rat inner medullary collecting duct cells.
Faust, D., Geelhaar, A., Eisermann, B., Eichhorst, J., Wiesner, B., Rosenthal, W. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Journal of Visualized Experiments (76): e50366. 21 June 2013

Small-molecule screening identifies modulators of aquaporin-2 trafficking.
Bogum, J., Faust, D., Zühlke, K., Eichhorst, J., Moutty, M.C., Furkert, J., Eldahshan, A., Neuenschwander, M. ORCID: https://orcid.org/0000-0002-3114-7975, von Kries, J.P. ORCID: https://orcid.org/0000-0003-4716-4988, Wiesner, B., Trimpert, C., Deen, P.M., Valenti, G., Rosenthal, W. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Journal of the American Society of Nephrology 24 (5): 744-758. April 2013

2012

Mechanism for targeting the A-kinase anchoring protein AKAP18δ to the membrane.
Horner, A., Goetz, F., Tampe, R., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003 and Pohl, P.
Journal of Biological Chemistry 287 (51): 42495-42501. 14 December 2012

A key phosphorylation site in AC8 mediates regulation of Ca2+-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.
Willoughby, D., Halls, M.L., Everett, K.L., Skroblin, P. ORCID: https://orcid.org/0000-0003-0321-3493, Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003 and Cooper, D.M.F.
Journal of Cell Science 125 (Pt 23): 5850-5859. 1 December 2012

Vasopressin increases S261 phosphorylation in AQP2-P262L, a mutant in recessive nephrogenic diabetes insipidus.
Trimpert, C., van den Berg, D.T.M., Fenton, R.A., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003 and Deen, P.M.T.
Nephrology Dialysis Transplantation 27 (12): 4389-4397. December 2012

The protease-activated receptor 1 possesses a functional and cleavable signal peptide which is necessary for receptor expression.
Zampatis, D.E., Rutz, C., Furkert, J., Schmidt, A., Wuestenhagen, D., Kubick, S., Tsopanoglou, N.E. and Schuelein, R.
FEBS Letters 586 (16): 2351-2359. 31 May 2012

A-kinase anchoring proteins as potential drug targets.
Troeger, J., Moutty, M.C., Skroblin, P. ORCID: https://orcid.org/0000-0003-0321-3493 and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
British Journal of Pharmacology 166 (2): 420-433. May 2012

Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling.
Willoughby, D., Everett, K.L., Halls, M.L., Pacheco, J., Skroblin, P. ORCID: https://orcid.org/0000-0003-0321-3493, Vaca, L., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003 and Cooper, D.M.
Science Signaling 5 (219): ra29. 10 April 2012

Functional significance of cleavable signal peptides of G protein-coupled receptors.
Schuelein, R., Westendorf, C., Krause, G. and Rosenthal, W.
European Journal of Cell Biology 91 (4): 294-299. April 2012

2011

Spinophilin regulates central angiotensin II-mediated effect on blood pressure.
da Costa Goncalves, A.C., Fontes, M.A., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Qadri, F. ORCID: https://orcid.org/0000-0002-8500-489X, Janke, J. ORCID: https://orcid.org/0000-0003-0113-4118, Gollasch, M. ORCID: https://orcid.org/0000-0003-2797-1934, Schleifenbaum, J. ORCID: https://orcid.org/0000-0002-3195-1517, Müller, D. ORCID: https://orcid.org/0000-0003-3650-5644, Jordan, J. ORCID: https://orcid.org/0000-0003-4518-0706, Tank, J., Luft, F.C. ORCID: https://orcid.org/0000-0002-8635-1199 and Gross, V.
Journal of Molecular Medicine 89 (12): 1219-1229. December 2011

Inhibition of the biosynthesis of the human endothelin B receptor by the cyclodepsipeptide cotransin.
Westendorf, C., Schmidt, A., Coin, I. ORCID: https://orcid.org/0000-0002-7722-004X, Furkert, J., Ridelis, I., Zampatis, D., Rutz, C., Wiesner, B., Rosenthal, W., Beyermann, M. and Schuelein, R.
Journal of Biological Chemistry 286 (41): 35588-35600. 14 October 2011

Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function.
Murdoch, H., Vadrevu, S., Prinz, A., Dunlop, A.J., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Bolger, G.B., Norman, J.C. and Houslay, M.D.
Journal of Cell Science 124 (Pt 13): 2253-2266. 1 July 2011

Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4).
Day, J.P., Lindsay, B., Riddell, T., Jiang, Z., Allcock, R.W., Abraham, A., Sookup, S., Christian, F., Bogum, J., Martin, E.K., Rae, R.L., Anthony, D., Rosair, G.M., Houslay, D.M., Huston, E., Baillie, G.S., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Houslay, M.D. and Adams, D.R.
Journal of Medicinal Chemistry 54 (9): 3331-3347. 12 May 2011

Small molecule AKAP/PKA interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes.
Christian, F., Szaszak, M., Friedl, S., Drewianka, S., Lorenz, D., Goncalves, A., Furkert, J., Vargas, C., Schmieder, P. ORCID: https://orcid.org/0000-0001-9968-9327, Goetz, F., Zuehlke, K., Moutty, M., Goettert, H., Joshi, M., Reif, B., Haase, H., Morano, I. ORCID: https://orcid.org/0000-0001-7315-2222, Grossmann, S., Klukovits, A., Verli, J., Gaspar, R., Noack, C., Bergmann, M., Kass, R., Hampel, K., Kashin, D., Genieser, H.G., Herberg, F.W., Willoughby, D., Cooper, D.M., Baillie, G.S., Houslay, M.D., von Kries, J.P. ORCID: https://orcid.org/0000-0003-4716-4988, Zimmermann, B., Rosenthal, W. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Journal of Biological Chemistry 286 (11): 9079-9096. 18 March 2011

2010

Routes of epithelial water flow: aquaporins versus cotransporters.
Mollajew, R., Zocher, F., Horner, A., Wiesner, B., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003 and Pohl, P.
Biophysical Journal 99 (11): 3647-3656. 1 December 2010

The pseudo signal peptide of the corticotropin-releasing factor receptor type 2a decreases receptor expression and prevents Gi-mediated inhibition of adenylyl cyclase activity.
Schulz, K., Rutz, C., Westendorf, C., Ridelis, I., Vogelbein, S., Furkert, J., Schmidt, A., Wiesner, B. and Schuelein, R.
Journal of Biological Chemistry 285 (43): 32878-32887. 22 October 2010

Reciprocal regulation of aquaporin-2 abundance and degradation by protein kinase A and p38-MAP kinase.
Nedvetsky, P.I., Tabor, V., Tamma, G., Beulshausen, S., Skroblin, P. ORCID: https://orcid.org/0000-0003-0321-3493, Kirschner, A., Mutig, K., Boltzen, M., Petrucci, O., Vossenkaemper, A., Wiesner, B., Bachmann, S., Rosenthal, W. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Journal of the American Society of Nephrology 21 (10): 1645-1656. October 2010

Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.
Li, X., Vadrevu, S., Dunlop, A., Day, J., Advant, N., Troeger, J., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Jaffrey, E., Hay, R.T., Adams, D.R., Houslay, M.D. and Baillie, G.S.
Biochemical Journal 428 (1): 55-65. 15 May 2010

Glycogen synthase kinase 3β interaction protein functions as an A-kinase anchoring protein.
Hundsrucker, C., Skroblin, P. ORCID: https://orcid.org/0000-0003-0321-3493, Christian, F., Zenn, M., Popara, V., Joshi, M., Eichhorst, J., Wiesner, B., Herberg, F.W., Reif, B., Rosenthal, W. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Journal of Biological Chemistry 285 (8): 5507-5521. 19 February 2010

Mechanisms of protein kinase A anchoring.
Skroblin, P. ORCID: https://orcid.org/0000-0003-0321-3493, Grossmann, S., Schaefer, G., Rosenthal, W. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
International Review of Cell and Molecular Biology 283 (C): 235-330. 2010

2009

MEK1 binds directly to βarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization.
Meng, D., Lynch, M.J., Huston, E., Beyermann, M., Eichhorst, J., Adams, D.R., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Houslay, M.D. and Baillie, G.S.
Journal of Biological Chemistry 284 (17): 11425-1135. 24 April 2009

Regulation of aquaporin-2 trafficking.
Nedvetsky, P.I., Tamma, G., Beulshausen, S., Valenti, G., Rosenthal, W. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Handbook of Experimental Pharmacology 190 (II): 133-157. 2009

2008

Compartmentalized cAMP signalling in regulated exocytic processes in non-neuronal cells.
Szaszak, M., Christian, F., Rosenthal, W. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Cellular Signalling 20 (4): 590-601. April 2008

Direct AKAP-mediated protein-protein interactions as potential drug targets.
Hundsrucker, C. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Handbook of Experimental Pharmacology 186 : 483-503. 2008

2007

1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1.
Smith, K.J., Baillie, G.S., Hyde, E.I., Li, X., Houslay, T.M., McCahill, A., Dunlop, A.J., Bolger, G.B., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Adams, D.R. and Houslay, M.D.
Cellular Signalling 19 (12): 2612-2624. December 2007

AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum.
Lygren, B., Carlson, C.R., Santamaria, K., Lissandron, V., McSorley, T., Litzenberg, J., Lorenz, D., Wiesner, B., Rosenthal, W., Zaccolo, M., Tasken, K. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
EMBO Reports 8 (11): 1061-1067. 1 November 2007

Microtubules are needed for the perinuclear positioning of aquaporin-2 after its endocytic retrieval in renal principal cells.
Vossenkaemper, A., Nedvetsky, P.I., Wiesner, B., Furkert, J., Rosenthal, W. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
American Journal of Physiology Cell Physiology 293 (3): C1129-C1138. 11 September 2007

Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels.
Murdoch, H., Mackie, S., Collins, D.M., Hill, E.V., Bolger, G.B., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Porteous, D.J., Millar, J.K. and Houslay, M.D.
Journal of Neuroscience 27 (35): 9513-9524. 29 August 2007

p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway.
Sachs, B.D., Baillie, G.S., McCall, J.R., Passino, M.A., Schachtrup, C., Wallace, D.A., Dunlop, A.J., MacKenzie, K.F., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Lynch, M.J., Sikorski, S.L., Nuriel, T., Tsigelny, I., Zhang, J., Houslay, M.D., Chao, M.V. and Akassoglou, K.
Journal of Cell Biology 177 (6): 1119-1132. 18 June 2007

Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays.
Baillie, G.S., Adams, D.R., Bhari, N., Houslay, T.M., Vadrevu, S., Meng, D., Li, X., Dunlop, A., Milligan, G., Bolger, G.B., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003 and Houslay, M.D.
Biochemical Journal 404 (1): 71-80. 15 May 2007

A role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle.
Nedvetsky, P.I., Stefan, E., Frische, S., Santamaria, K., Wiesner, B., Valenti, G., Hammer, J.A., Nielsen, S., Goldenring, J.R., Rosenthal, W. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Traffic 8 (2): 110-123. February 2007

Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.
Stefan, E., Wiesner, B., Baillie, G.S., Mollajew, R., Henn, V., Lorenz, D., Furkert, J., Santamaria, K., Nedvetsky, P.I., Hundsrucker, C., Beyermann, M., Krause, E., Pohl, P., Gall, I., MacIntyre, A.N., Bachmann, S., Houslay, M.D., Rosenthal, W. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Journal of the American Society of Nephrology 18 (1): 199-212. January 2007

Protein-Protein-Interaktionen als Ziel fuer neue Pharmaka : EU-Projekt thera-cAMP.
Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
BIOforum 2 : 32-34. 2007

Protein-protein interactions as target for new therapeutic molecules.
Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
BIOforum Europe 3 : 18-19. 2007

2006

Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5.
Bolger, G.B., Baillie, G.S., Li, X., Lynch, M.J., Herzyk, P., Mohamed, A., Mitchell, L.H., McCahill, A., Hundsrucker, C., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Adams, D.R. and Houslay, M.D.
Biochemical Journal 398 (1): 23-36. 15 August 2006

Peptides for disruption of PKA anchoring.
Hundsrucker, C., Rosenthal, W. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Biochemical Society Transactions 34 (Pt 4): 472-473. 1 August 2006

First international meeting on anchored cAMP signaling pathways, Biomedical Campus, Berlin-Buch, Germany, 15-16 October 2005.
Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
European Journal of Cell Biology 85 (7): 581-584. 5 July 2006

Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells.
McSorley, T., Stefan, E., Henn, V., Wiesner, B., Baillie, G.S., Houslay, M.D., Rosenthal, W. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
European Journal of Cell Biology 85 (7): 673-678. 5 July 2006

High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides.
Hundsrucker, C., Krause, G., Beyermann, M., Prinz, A., Zimmermann, B., Diekmann, O., Lorenz, D., Stefan, E., Nedvetsky, P., Dathe, M., Christian, F., McSorley, T., Krause, E., McConnachie, G., Herberg, F.W., Scott, J.D., Rosenthal, W. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Biochemical Journal 396 (2): 297-306. 1 June 2006

AKAP7.
Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003 and Rosenthal, W.
UCSD Nature Molecule Pages 4 April 2006

2005

Compartmentalized cAMP signalling regulates vasopressin-mediated water reabsorption by controlling aquaporin-2.
Henn, V., Stefan, E., Baillie, G.S., Houslay, M.D., Rosenthal, W. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Biochemical Society Transactions 33 (Pt 6): 1316-1318. December 2005

Actin remodeling requires ERM function to facilitate AQP2 apical targeting.
Tamma, G., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Oehlke, J., Krause, E., Rosenthal, W., Svelto, M. and Valenti, G.
Journal of Cell Science 118 (Pt 16): 3623-3630. 15 August 2005

2004

Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells.
Henn, V., Edemir, B., Stefan, E., Wiesner, B., Lorenz, D., Theilig, F., Schmitt, R., Vossebein, L., Tamma, G., Beyermann, M., Krause, E., Herberg, F.W., Valenti, G., Bachmann, S., Rosenthal, W. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Journal of Biological Chemistry 279 (25): 26654-26665. 18 June 2004

2003

The prostaglandin E2 analogue sulprostone antagonizes vasopressin-induced antidiuresis through activation of Rho.
Tamma, G., Wiesner, B., Furkert, J., Hahm, D., Oksche, A., Schaefer, M., Valenti, G., Rosenthal, W. and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Journal of Cell Science 116 (Pt 16): 3285-3294. 15 August 2003

Renal expression of sodium transporters and aquaporin-2 in hypothyroid rats.
Schmitt, R., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Kahl, T., Ellison, D.H. and Bachmann, S.
American Journal of Physiology Renal Physiology 284 (5): F1097-F1104. May 2003

cAMP-induced AQP2 translocation is associated with RhoA inhibition through RhoA phosphorylation and interaction with RhoGDI.
Tamma, G., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Procino, G., Svelto, M., Rosenthal, W. and Valenti, G.
Journal of Cell Science 116 (Pt 8): 1519-1525. 15 April 2003

Osmolality and solute composition are strong regulators of AQP2 expression in renal principal cells.
Storm, R., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Geelhaar, A., Rosenthal, W. and Maric, K.
American Journal of Physiology Renal Physiology 284 (1): F189-F198. January 2003

2001

Rho inhibits cAMP-induced translocation of aquaporin-2 into the apical membrane of renal cells.
Tamma, G., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Maric, K., Aktories, K., Svelto, M., Rosenthal, W. and Valenti, G.
American Journal of Physiology Renal Physiology 281 (6): F1092-F1101. December 2001

Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling.
Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Edemir, B., Pepperle, B., Tamma, G., Henn, V., Klauschenz, E., Hundsrucker, C., Maric, K. and Rosenthal, W.
FEBS Letters 507 (3): 264-268. 2 November 2001

Role and identification of protein kinase A anchoring proteins in vasopressin-mediated aquaporin-2 translocation.
Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003 and Rosenthal, W.
Kidney International 60 (2): 446-449. August 2001

An inhibitory role of Rho in the vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells.
Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Tamma, G., Lorenz, D., Wiesner, B., Maric, K., Hofmann, F., Aktories, K., Valenti, G. and Rosenthal, W.
Journal of Biological Chemistry 276 (23): 20451-20457. 8 June 2001

Cell volume kinetics of adherent epithelial cells measured by laser scanning reflection microscopy: determination of water permeability changes of renal principal cells.
Maric, K., Wiesner, B., Lorenz, D., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Betz, T. and Rosenthal, W.
Biophysical Journal 80 (4): 1783-1790. April 2001

2000

The mechanisms of aquaporin control in the renal collecting duct.
Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Maric, K. and Rosenthal, W.
Reviews of Physiology Biochemistry and Pharmacology 141 : 33-95. 2000

1999

Protein kinase A anchoring proteins are required for vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells.
Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Maric, K., Wiesner, B., Beyermann, M. and Rosenthal, W.
Journal of Biological Chemistry 274 (8): 4934-4938. 19 February 1999

1997

MUC2 gene suppression in human colorectal carcinomas and their metastases: in vitro evidence of the modulatory role of DNA methylation.
Hanski, C., Riede, E., Gratchev, A., Foss, H.D., Boehm, C., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Hummel, M., Mann, B., Buhr, H.J., Stein, H., Kim, Y.S., Gum, J. and Riecken, E.O.
Laboratory Investigation 77 (6): 685-695. December 1997

Low O-acetylation of sialyl-Le(x) contributes to its overexpression in colon carcinoma metastases.
Mann, B., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Vandamme-Feldhaus, V., Iwersen, M., Hanski, M.L., Riecken, E.O., Buhr, H.J., Schauer, R., Kim, Y.S. and Hanski, C.
International Journal of Cancer 72 (2): 258-264. 17 July 1997

1996

Fucosyltransferase III and sialyl-Le(x) expression correlate in cultured colon carcinoma cells but not in colon carcinoma tissue.
Hanski, C., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Wang, J., Boehm, C., Ogorek, D., Hanski, M.L., Krueger-Krasagakes, S., Eberle, J., Schmitt-Graeff, A. and Riecken, E.O.
Glycoconjugate Journal 13 (5): 727-733. October 1996

1994

Expression of MUC2-mucin in colorectal adenomas and carcinomas of different histological types.
Blanke, M., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Krueger-Krasagakes, S., Schmitt-Graeff, A., Stolte, M., Bornhoeft, G., Stein, H., Xing, P.X., McKenzie, I.F., Verstijnen, C.P., Riecken, E.O. and Hanski, C.
International Journal of Cancer 59 (3): 301-306. 1 November 1994

1993

Altered glycosylation of the MUC-1 protein core contributes to the colon carcinoma-associated increase of mucin-bound sialyl-Lewis(x) expression.
Hanski, C., Drechsler, K., Hanisch, F.G., Sheehan, J., Manske, M., Ogorek, D., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003, Hanski, M.L., Blank, M., Xing, P.X., McKenzie, I.F.C., Devine, P.L. and Riecken, E.O.
Cancer Research 53 (17): 4082-4088. 1 September 1993