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Article

Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage.
Ercu, M. and Mücke, M.B. and Pallien, T. and Markó, L. and Sholokh, A. and Schächterle, C. and Aydin, A. and Kidd, A. and Walter, S. and Esmati, Y. and McMurray, B.J. and Lato, D.F. and Sunaga-Franze, D.Y. and Dierks, P.H. and Flores, B.I.M. and Walker-Gray, R. and Gong, M. and Merticariu, C. and Zühlke, K. and Russwurm, M. and Liu, T. and Batolomaeus, T.U.P. and Pautz, S. and Schelenz, S. and Taube, M. and Napieczynska, H. and Heuser, A. and Eichhorst, J. and Lehmann, M. and Miller, D.C. and Diecke, S. and Qadri, F. and Popova, E. and Langanki, R. and Movsesian, M.A. and Herberg, F.W. and Forslund, S.K. and Müller, D.N. and Borodina, T. and Maass, P.G. and Bähring, S. and Hübner, N. and Bader, M. and Klussmann, E.
Circulation 19 October 2022 (In Press)

A novel AQP2 sequence variant causing aquaporin-2 retention in the cytoplasm and autosomal dominant nephrogenic diabetes insipidus.
Hinrichs, G.R. and Baltzer, S. and Pallien, T. and Svenningsen, P. and Dalgaard, E.B. and Hertz, J.M. and Bistrup, C. and Jensen, B.L. and Klussmann, E.
Kidney International Reports 7 (10): 2289-2294. October 2022

Aurora kinase A is involved in controlling the localization of aquaporin-2 in renal principal cells.
Baltzer, S. and Bulatov, T. and Schmied, C. and Krämer, A. and Berger, B.T. and Oder, A. and Walker-Gray, R. and Kuschke, C. and Zühlke, K. and Eichhorst, J. and Lehmann, M. and Knapp, S. and Weston, J. and von Kries, J.P. and Süssmuth, R.D. and Klussmann, E.
International Journal of Molecular Sciences 23 (2): 763. 11 January 2022

AKAP18δ anchors and regulates CaMKII activity at phospholamban-SERCA2 and RYR.
Carlson, C.R. and Aronsen, J.M. and Bergan-Dahl, A. and Moutty, M.C. and Lunde, M. and Lunde, P.K. and Jarstadmarken, H. and Wanichawan, P. and Pereira, L. and Kolstad, T.R.S. and Dalhus, B. and Subramanian, H. and Hille, S. and Christensen, G. and Müller, O.J. and Nikolaev, V. and Bers, D.M. and Sjaastad, I. and Shen, X. and Louch, W.E. and Klussmann, E. and Sejersted, O.M.
Circulation Research 130 (1): 27-44. 7 January 2022

Disruptors of AKAP-dependent protein-protein interactions.
Walker-Gray, R. and Pallien, T. and Miller, D.C. and Oder, A. and Neuenschwander, M. and von Kries, J.P. and Diecke, S. and Klussmann, E.
Methods in Molecular Biology 2483 : 117-139. 2022

Reconstitution of β-adrenergic regulation of Ca(V)1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.
Katz, M. and Subramaniam, S. and Chomsky-Hecht, O. and Tsemakhovich, V. and Flockerzi, V. and Klussmann, E. and Hirsch, J.A. and Weiss, S. and Dascal, N.
Proceedings of the National Academy of Sciences of the United States of America 118 (21): e2100021118. 17 May 2021

Improving target assessment in biomedical research: the GOT-IT recommendations.
Emmerich, C.H. and Gamboa, L.M. and Hofmann, M.C.J. and Bonin-Andresen, M. and Arbach, O. and Schendel, P. and Gerlach, B. and Hempel, K. and Bespalov, A. and Dirnagl, U. and Parnham, M.J.
Nature Reviews Drug Discovery 20 (1): 64-81. January 2021

Phosphodiesterase 3A and arterial hypertension.
Ercu, M. and Markó, L. and Schächterle, C. and Tsvetkov, D. and Cui, Y. and Maghsodi, S. and Bartolomaeus, T.U.P. and Maass, P.G. and Zühlke, K. and Gregersen, N. and Hübner, N. and Hodge, R. and Mühl, A. and Pohl, B. and Molé-Illas, R. and Geelhaar, A. and Walter, S. and Napieczynska, H. and Schelenz, S. and Taube, M. and Heuser, A. and Anistan, Y.M. and Qadri, F. and Todiras, M. and Plehm, R. and Popova, E. and Langanki, R. and Eichhorst, J. and Lehmann, M. and Wiesner, B. and Russwurm, M. and Forslund, S.K. and Kamer, I. and Müller, D.N. and Gollasch, M. and Aydin, A. and Bähring, S. and Bader, M. and Luft, F.C. and Klussmann, E.
Circulation 142 (2): 133-149. 14 July 2020

Cyclin-dependent kinase 18 controls trafficking of aquaporin-2 and its abundance through ubiquitin ligase STUB1, which functions as an AKAP.
Dema, A. and Faust, D. and Lazarow, K. and Wippich, M. and Neuenschwander, M. and Zühlke, K. and Geelhaar, A. and Pallien, T. and Hallscheidt, E. and Eichhorst, J. and Wiesner, B. and Cernecká, H. and Popp, O. and Mertins, P. and Dittmar, G. and von Kries, J.P. and Klussmann, E.
Cells 9 (3): 673. 10 March 2020

Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1.
Zhao, X. and Nedvetsky, P. and Stanchi, F. and Vion, A.C. and Popp, O. and Zühlke, K. and Dittmar, G. and Klussmann, E. and Gerhardt, H.
eLife 8 : e46380. 3 October 2019

Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases.
Omar, F. and Findlay, J.E. and Carfray, G. and Allcock, R.W. and Jiang, Z. and Moore, C. and Muir, A.L. and Lannoy, M. and Fertig, B.A. and Mai, D. and Day, J.P. and Bolger, G. and Baillie, G.S. and Schwiebert, E. and Klussmann, E. and Pyne, N.J. and Ong, A.C.M. and Bowers, K. and Adam, J.M. and Adams, D.R. and Houslay, M.D. and Henderson, D.J.P.
Proceedings of the National Academy of Sciences of the United States of America 116 (27): 13320-13329. 2 July 2019

Fluconazole increases osmotic water transport in renal collecting duct through effects on aquaporin-2 trafficking.
Vukićević, T. and Hinze, C. and Baltzer, S. and Himmerkus, N. and Quintanova, C. and Zühlke, K. and Compton, F. and Ahlborn, R. and Dema, A. and Eichhorst, J. and Wiesner, B. and Bleich, M. and Schmidt-Ott, K.M. and Klussmann, E.
Journal of the American Society of Nephrology 30 (5): 795-810. May 2019

Anoctamin-4 is a bona fide Ca(2+)-dependent non-selective cation channel.
Reichhart, N. and Schöberl, S. and Keckeis, S. and Alfaar, A.S. and Roubeix, C. and Cordes, M. and Crespo-Garcia, S. and Haeckel, A. and Kociok, N. and Föckler, R. and Fels, G. and Mataruga, A. and Rauh, R. and Milenkovic, V.M. and Zühlke, K. and Klussmann, E. and Schellenberger, E. and Strauß, O.
Scientific Reports 9 (1): 2257. 19 February 2019

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis.
Campa, C.C. and Silva, R.L. and Margaria, J.P. and Pirali, T. and Mattos, M.S. and Kraemer, L.R. and Reis, D.C. and Grosa, G. and Copperi, F. and Dalmarco, E.M. and Lima-Júnior, R.C.P. and Aprile, S. and Sala, V. and Dal Bello, F. and Prado, D.S. and Alves-Filho, J.C. and Medana, C. and Cassali, G.D. and Tron, G.C. and Teixeira, M.M. and Ciraolo, E. and Russo, R.C. and Hirsch, E.
Nature Communications 9 (1): 5232. 12 December 2018

An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.
Schrade, K. and Tröger, J. and Eldahshan, A. and Zühlke, K. and Abdul Azeez, K.R. and Elkins, J.M. and Neuenschwander, M. and Oder, A. and Elkewedi, M.M.H. and Jaksch, S. and Andrae, K. and Li, J. and Fernandes, J. and Müller, P.M. and Grunwald, S. and Marino, S.F. and Vukićević, T. and Eichhorst, J. and Wiesner, B. and Weber, M. and Kapiloff, M. and Rocks, O. and Daumke, O. and Wieland, T. and Knapp, S. and von Kries, J.P. and Klussmann, E.
PLoS ONE 13 (1): e0191423. 26 January 2018

Protein kinase C enhances plasma membrane expression of cardiac L-type calcium channel, Ca(V)1.2.
Raifman, T.K. and Kumar, P. and Haase, H. and Klussmann, E. and Dascal, N. and Weiss, S.
Channels 11 (6): 604-615. 2 November 2017

Protein kinase A regulates C-terminally truncated Ca(V) 1.2 in Xenopus oocytes: roles of N- and C-termini of the α(1C) subunit.
Oz, S. and Pankonien, I. and Belkacemi, A. and Flockerzi, V. and Klussmann, E. and Haase, H. and Dascal, N.
Journal of Physiology 595 (10): 3181-3202. 15 May 2017

Bimodal antagonism of PKA signalling by ARHGAP36.
Eccles, R.L. and Czajkowski, M.T. and Barth, C. and Müller, P.M. and McShane, E. and Grunwald, S. and Beaudette, P. and Mecklenburg, N. and Volkmer, R. and Zühlke, K. and Dittmar, G. and Selbach, M. and Hammes, A. and Daumke, O. and Klussmann, E. and Urbé, S. and Rocks, O.
Nature Communications 7 : 12963. 7 October 2016

The A-kinase anchoring protein (AKAP) glycogen synthase kinase 3β interaction protein (GSKIP) regulates β-catenin through its interactions with both protein kinase A (PKA) and GSK3β.
Dema, A. and Schröter, M.F. and Perets, E. and Skroblin, P. and Moutty, M.C. and Deàk, V.A. and Birchmeier, W. and Klussmann, E.
Journal of Biological Chemistry 291 (37): 19618-19630. 9 September 2016

Pharmacological interference with protein-protein interactions of A-kinase anchoring proteins as a strategy for the treatment of disease.
Deák, V.A. and Klussmann, E.
Current Drug Targets 17 (10): 1147-1171. 1 August 2016

AKAP18:PKA-RIIα structure reveals crucial anchor points for recognition of regulatory subunits of PKA.
Götz, F. and Roske, Y. and Schulz, M.S. and Autenrieth, K. and Bertinetti, D. and Faelber, K. and Zühlke, K. and Kreuchwig, A. and Kennedy, E. and Krause, G. and Daumke, O. and Herberg, F.W. and Heinemann, U. and Klussmann, E.
Biochemical Journal 473 (13): 1881-1894. 28 June 2016

The A-kinase anchoring protein GSKIP regulates GSK3β activity and controls palatal shelf fusion in mice.
Deák, V.A. and Skroblin, P. and Dittmayer, C. and Knobeloch, K.P. and Bachmann, S. and Klussmann, E.
Journal of Biological Chemistry 291 (2): 681-690. 8 January 2016

Clinical effects of phosphodiesterase 3A mutations in inherited hypertension with brachydactyly.
Toka, O. and Tank, J. and Schächterle, C. and Aydin, A. and Maass, P.G. and Elitok, S. and Bartels-Klein, E. and Hollfinger, I. and Lindschau, C. and Mai, K. and Boschmann, M. and Rahn, G. and Movsesian, M.A. and Müller, T. and Doescher, A. and Gnoth, S. and Mühl, A. and Toka, H.R. and Wefeld-Neuenfeld, Y. and Utz, W. and Töpper, A. and Jordan, J. and Schulz-Menger, J. and Klussmann, E. and Bähring, S. and Luft, F.C.
Hypertension 66 (4): 800-808. October 2015

Neurochondrin is an atypical RIIα-specific A-kinase anchoring protein.
Hermann, J.S. and Skroblin, P. and Bertinetti, D. and Hanold, L.E. and von der Heide, E.K. and Wagener, E.M. and Zenn, H.M. and Klussmann, E. and Kennedy, E.J. and Herberg, F.W.
Biochimica et Biophysica Acta - Proteins and Proteomics 1854 (10 Pt B): 1667-1675. October 2015

PDE3A mutations cause autosomal dominant hypertension with brachydactyly.
Maass, P.G. and Aydin, A. and Luft, F.C. and Schächterle, C. and Weise, A. and Stricker, S. and Lindschau, C. and Vaegler, M. and Qadri, F. and Toka, H.R. and Schulz, H. and Krawitz, P.M. and Parkhomchuk, D. and Hecht, J. and Hollfinger, I. and Wefeld-Neuenfeld, Y. and Bartels-Klein, E. and Mühl, A. and Kann, M. and Schuster, H. and Chitayat, D. and Bialer, M.G. and Wienker, T.F. and Ott, J. and Rittscher, K. and Liehr, T. and Jordan, J. and Plessis, G. and Tank, J. and Mai, K. and Naraghi, R. and Hodge, R. and Hopp, M. and Hattenbach, L.O. and Busjahn, A. and Rauch, A. and Vandeput, F. and Gong, M. and Rüschendorf, F. and Hübner, N. and Haller, H. and Mundlos, S. and Bilginturan, N. and Movsesian, M.A. and Klussmann, E. and Toka, O. and Bähring, S.
Nature Genetics 47 (6): 647-653. June 2015

A-kinase anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle.
Poppinga, W.J. and Heijink, I.H. and Holtzer, L.J. and Skroblin, P. and Klussmann, E. and Halayko, A.J. and Timens, W. and Maarsingh, H. and Schmidt, M.
American Journal of Physiology Lung Cellular and Molecular Physiology 308 (8): L766-L775. 15 April 2015

Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains.
Bolger, G.B. and Dunlop, A.J. and Meng, D. and Day, J.P. and Klussmann, E. and Baillie, G.S. and Adams, D.R. and Houslay, M.D.
Cellular Signalling 27 (4): 756-769. April 2015

Regulation of sarcoplasmic reticulum Ca(2+) ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2.
Ahmad, F. and Shen, W. and Vandeput, F. and Szabo-Fresnais, N. and Krall, J. and Degerman, E. and Goetz, F. and Klussmann, E. and Movsesian, M. and Manganiello, V.
Journal of Biological Chemistry 290 (11): 6763-6776. 13 March 2015

Screening for small molecule disruptors of AKAP-PKA interactions.
Schächterle, C. and Christian, F. and Fernandes, J.M.P. and Klussmann, E.
Methods in Molecular Biology 1294 : 151-166. 2 March 2015

Keeping those telomeres short! an innovative intratumoral long-term drug delivery system.
Laster, B.H. and Isaacson, C. and Perets, E. and Msamra, M. and Priel, E. and Kalef-Ezra, J. and Kost, J.
Journal of Cancer Research and Clinical Oncology 141 (1): 23-34. January 2015

The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex.
Abdul Azeez, K.R. and Knapp, S. and Fernandes, J.M.P. and Klussmann, E. and Elkins, J.M.
Biochemical Journal 464 (2): 231-239. 1 December 2014

Flexible, polymer-supported synthesis of sphingosine derivatives provides ceramides with enhanced biological activity.
El-Dahshan, A. and Al-Gharabli, S.I. and Radetzki, S. and Al-Tel, T.H. and Kumar, P. and Rademann, J.
Bioorganic and Medicinal Chemistry 22 (19): 5506-5512. 1 October 2014

G protein-coupled estrogen receptor 1 (GPER) mediates relaxation of coronary arteries via cAMP/PKA-dependent activation of MLCP.
Yu, X. and Li, F. and Klussmann, E. and Stallone, J.N. and Han, G.
American Journal of Physiology Endocrinology and Metabolism 307 (4): E398-E407. 15 August 2014

Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.
Schäfer, G. and Milić, J and Eldahshan, A and Götz, F. and Zühlke, K. and Schillinger, C. and Kreuchwig, A. and Elkins, J.M. and Abdul Azeez, K.R.A. and Oder, A. and Moutty, M.C. and Masada, N. and Beerbaum, M. and Schlegel, B. and Niquet, S. and Schmieder, P. and Krause, G. and von Kries, J.P. and Cooper, D.M.F. and Knapp, S. and Rademann, J. and Rosenthal, W. and Klussmann, E.
Angewandte Chemie International Edition 52 (46): 12187-12191. 11 November 2013

AKAPS act in a two-step mechanism of memory acquisition.
Scheunemann, L. and Skroblin, P. and Hundsrucker, C. and Klussmann, E. and Efetova, M. and Schwärzel, M.
Journal of Neuroscience 33 (44): 17422-17428. 30 October 2013

Culturing primary rat inner medullary collecting duct cells.
Faust, D. and Geelhaar, A. and Eisermann, B. and Eichhorst, J. and Wiesner, B. and Rosenthal, W. and Klussmann, E.
Journal of Visualized Experiments (76): e50366. 21 June 2013

Small-molecule screening identifies modulators of aquaporin-2 trafficking.
Bogum, J. and Faust, D. and Zühlke, K. and Eichhorst, J. and Moutty, M.C. and Furkert, J. and Eldahshan, A. and Neuenschwander, M. and von Kries, J.P. and Wiesner, B. and Trimpert, C. and Deen, P.M. and Valenti, G. and Rosenthal, W. and Klussmann, E.
Journal of the American Society of Nephrology 24 (5): 744-758. April 2013

Mechanism for targeting the A-kinase anchoring protein AKAP18δ to the membrane.
Horner, A. and Goetz, F. and Tampe, R. and Klussmann, E. and Pohl, P.
Journal of Biological Chemistry 287 (51): 42495-42501. 14 December 2012

A key phosphorylation site in AC8 mediates regulation of Ca2+-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.
Willoughby, D. and Halls, M.L. and Everett, K.L. and Skroblin, P. and Klussmann, E. and Cooper, D.M.F.
Journal of Cell Science 125 (Pt 23): 5850-5859. 1 December 2012

Vasopressin increases S261 phosphorylation in AQP2-P262L, a mutant in recessive nephrogenic diabetes insipidus.
Trimpert, C. and van den Berg, D.T.M. and Fenton, R.A. and Klussmann, E. and Deen, P.M.T.
Nephrology Dialysis Transplantation 27 (12): 4389-4397. December 2012

The protease-activated receptor 1 possesses a functional and cleavable signal peptide which is necessary for receptor expression.
Zampatis, D.E. and Rutz, C. and Furkert, J. and Schmidt, A. and Wuestenhagen, D. and Kubick, S. and Tsopanoglou, N.E. and Schuelein, R.
FEBS Letters 586 (16): 2351-2359. 31 May 2012

Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling.
Willoughby, D. and Everett, K.L. and Halls, M.L. and Pacheco, J. and Skroblin, P. and Vaca, L. and Klussmann, E. and Cooper, D.M.
Science Signaling 5 (219): ra29. 10 April 2012

Spinophilin regulates central angiotensin II-mediated effect on blood pressure.
da Costa Goncalves, A.C. and Fontes, M.A. and Klussmann, E. and Qadri, F. and Janke, J. and Gollasch, M. and Schleifenbaum, J. and Mueller, D. and Jordan, J. and Tank, J. and Luft, F.C. and Gross, V.
Journal of Molecular Medicine 89 (12): 1219-1229. December 2011

Inhibition of the biosynthesis of the human endothelin B receptor by the cyclodepsipeptide cotransin.
Westendorf, C. and Schmidt, A. and Coin, I. and Furkert, J. and Ridelis, I. and Zampatis, D. and Rutz, C. and Wiesner, B. and Rosenthal, W. and Beyermann, M. and Schuelein, R.
Journal of Biological Chemistry 286 (41): 35588-35600. 14 October 2011

Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function.
Murdoch, H. and Vadrevu, S. and Prinz, A. and Dunlop, A.J. and Klussmann, E. and Bolger, G.B. and Norman, J.C. and Houslay, M.D.
Journal of Cell Science 124 (Pt 13): 2253-2266. 1 July 2011

Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4).
Day, J.P. and Lindsay, B. and Riddell, T. and Jiang, Z. and Allcock, R.W. and Abraham, A. and Sookup, S. and Christian, F. and Bogum, J. and Martin, E.K. and Rae, R.L. and Anthony, D. and Rosair, G.M. and Houslay, D.M. and Huston, E. and Baillie, G.S. and Klussmann, E. and Houslay, M.D. and Adams, D.R.
Journal of Medicinal Chemistry 54 (9): 3331-3347. 12 May 2011

Small molecule AKAP/PKA interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes.
Christian, F. and Szaszak, M. and Friedl, S. and Drewianka, S. and Lorenz, D. and Goncalves, A. and Furkert, J. and Vargas, C. and Schmieder, P. and Goetz, F. and Zuehlke, K. and Moutty, M. and Goettert, H. and Joshi, M. and Reif, B. and Haase, H. and Morano, I. and Grossmann, S. and Klukovits, A. and Verli, J. and Gaspar, R. and Noack, C. and Bergmann, M. and Kass, R. and Hampel, K. and Kashin, D. and Genieser, H.G. and Herberg, F.W. and Willoughby, D. and Cooper, D.M. and Baillie, G.S. and Houslay, M.D. and von Kries, J.P. and Zimmermann, B. and Rosenthal, W. and Klussmann, E.
Journal of Biological Chemistry 286 (11): 9079-9096. 18 March 2011

Routes of epithelial water flow: aquaporins versus cotransporters.
Mollajew, R. and Zocher, F. and Horner, A. and Wiesner, B. and Klussmann, E. and Pohl, P.
Biophysical Journal 99 (11): 3647-3656. 1 December 2010

The pseudo signal peptide of the corticotropin-releasing factor receptor type 2a decreases receptor expression and prevents Gi-mediated inhibition of adenylyl cyclase activity.
Schulz, K. and Rutz, C. and Westendorf, C. and Ridelis, I. and Vogelbein, S. and Furkert, J. and Schmidt, A. and Wiesner, B. and Schuelein, R.
Journal of Biological Chemistry 285 (43): 32878-32887. 22 October 2010

Reciprocal regulation of aquaporin-2 abundance and degradation by protein kinase A and p38-MAP kinase.
Nedvetsky, P.I. and Tabor, V. and Tamma, G. and Beulshausen, S. and Skroblin, P. and Kirschner, A. and Mutig, K. and Boltzen, M. and Petrucci, O. and Vossenkaemper, A. and Wiesner, B. and Bachmann, S. and Rosenthal, W. and Klussmann, E.
Journal of the American Society of Nephrology 21 (10): 1645-1656. October 2010

Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.
Li, X. and Vadrevu, S. and Dunlop, A. and Day, J. and Advant, N. and Troeger, J. and Klussmann, E. and Jaffrey, E. and Hay, R.T. and Adams, D.R. and Houslay, M.D. and Baillie, G.S.
Biochemical Journal 428 (1): 55-65. 15 May 2010

Glycogen synthase kinase 3β interaction protein functions as an A-kinase anchoring protein.
Hundsrucker, C. and Skroblin, P. and Christian, F. and Zenn, M. and Popara, V. and Joshi, M. and Eichhorst, J. and Wiesner, B. and Herberg, F.W. and Reif, B. and Rosenthal, W. and Klussmann, E.
Journal of Biological Chemistry 285 (8): 5507-5521. 19 February 2010

MEK1 binds directly to βarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization.
Meng, D. and Lynch, M.J. and Huston, E. and Beyermann, M. and Eichhorst, J. and Adams, D.R. and Klussmann, E. and Houslay, M.D. and Baillie, G.S.
Journal of Biological Chemistry 284 (17): 11425-1135. 24 April 2009

1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1.
Smith, K.J. and Baillie, G.S. and Hyde, E.I. and Li, X. and Houslay, T.M. and McCahill, A. and Dunlop, A.J. and Bolger, G.B. and Klussmann, E. and Adams, D.R. and Houslay, M.D.
Cellular Signalling 19 (12): 2612-2624. December 2007

AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum.
Lygren, B. and Carlson, C.R. and Santamaria, K. and Lissandron, V. and McSorley, T. and Litzenberg, J. and Lorenz, D. and Wiesner, B. and Rosenthal, W. and Zaccolo, M. and Tasken, K. and Klussmann, E.
EMBO Reports 8 (11): 1061-1067. 1 November 2007

Microtubules are needed for the perinuclear positioning of aquaporin-2 after its endocytic retrieval in renal principal cells.
Vossenkaemper, A. and Nedvetsky, P.I. and Wiesner, B. and Furkert, J. and Rosenthal, W. and Klussmann, E.
American Journal of Physiology Cell Physiology 293 (3): C1129-C1138. 11 September 2007

Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels.
Murdoch, H. and Mackie, S. and Collins, D.M. and Hill, E.V. and Bolger, G.B. and Klussmann, E. and Porteous, D.J. and Millar, J.K. and Houslay, M.D.
Journal of Neuroscience 27 (35): 9513-9524. 29 August 2007

p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway.
Sachs, B.D. and Baillie, G.S. and McCall, J.R. and Passino, M.A. and Schachtrup, C. and Wallace, D.A. and Dunlop, A.J. and MacKenzie, K.F. and Klussmann, E. and Lynch, M.J. and Sikorski, S.L. and Nuriel, T. and Tsigelny, I. and Zhang, J. and Houslay, M.D. and Chao, M.V. and Akassoglou, K.
Journal of Cell Biology 177 (6): 1119-1132. 18 June 2007

Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays.
Baillie, G.S. and Adams, D.R. and Bhari, N. and Houslay, T.M. and Vadrevu, S. and Meng, D. and Li, X. and Dunlop, A. and Milligan, G. and Bolger, G.B. and Klussmann, E. and Houslay, M.D.
Biochemical Journal 404 (1): 71-80. 15 May 2007

A role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle.
Nedvetsky, P.I. and Stefan, E. and Frische, S. and Santamaria, K. and Wiesner, B. and Valenti, G. and Hammer, J.A. and Nielsen, S. and Goldenring, J.R. and Rosenthal, W. and Klussmann, E.
Traffic 8 (2): 110-123. February 2007

Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.
Stefan, E. and Wiesner, B. and Baillie, G.S. and Mollajew, R. and Henn, V. and Lorenz, D. and Furkert, J. and Santamaria, K. and Nedvetsky, P.I. and Hundsrucker, C. and Beyermann, M. and Krause, E. and Pohl, P. and Gall, I. and MacIntyre, A.N. and Bachmann, S. and Houslay, M.D. and Rosenthal, W. and Klussmann, E.
Journal of the American Society of Nephrology 18 (1): 199-212. January 2007

Protein-Protein-Interaktionen als Ziel fuer neue Pharmaka : EU-Projekt thera-cAMP.
Klussmann, E.
BIOforum 2 : 32-34. 2007

Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5.
Bolger, G.B. and Baillie, G.S. and Li, X. and Lynch, M.J. and Herzyk, P. and Mohamed, A. and Mitchell, L.H. and McCahill, A. and Hundsrucker, C. and Klussmann, E. and Adams, D.R. and Houslay, M.D.
Biochemical Journal 398 (1): 23-36. 15 August 2006

Peptides for disruption of PKA anchoring.
Hundsrucker, C. and Rosenthal, W. and Klussmann, E.
Biochemical Society Transactions 34 (Pt 4): 472-473. 1 August 2006

Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells.
McSorley, T. and Stefan, E. and Henn, V. and Wiesner, B. and Baillie, G.S. and Houslay, M.D. and Rosenthal, W. and Klussmann, E.
European Journal of Cell Biology 85 (7): 673-678. 5 July 2006

High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides.
Hundsrucker, C. and Krause, G. and Beyermann, M. and Prinz, A. and Zimmermann, B. and Diekmann, O. and Lorenz, D. and Stefan, E. and Nedvetsky, P. and Dathe, M. and Christian, F. and McSorley, T. and Krause, E. and McConnachie, G. and Herberg, F.W. and Scott, J.D. and Rosenthal, W. and Klussmann, E.
Biochemical Journal 396 (2): 297-306. 1 June 2006

Compartmentalized cAMP signalling regulates vasopressin-mediated water reabsorption by controlling aquaporin-2.
Henn, V. and Stefan, E. and Baillie, G.S. and Houslay, M.D. and Rosenthal, W. and Klussmann, E.
Biochemical Society Transactions 33 (Pt 6): 1316-1318. December 2005

RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.
Lynch, M.J. and Baillie, G.S. and Mohamed, A. and Li, X. and Maisonneuve, C. and Klussmann, E. and van Heeke, G. and Houslay, M.D.
Journal of Biological Chemistry 280 (39): 33178-33189. 30 September 2005

Actin remodeling requires ERM function to facilitate AQP2 apical targeting.
Tamma, G. and Klussmann, E. and Oehlke, J. and Krause, E. and Rosenthal, W. and Svelto, M. and Valenti, G.
Journal of Cell Science 118 (Pt 16): 3623-3630. 15 August 2005

Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells.
Henn, V. and Edemir, B. and Stefan, E. and Wiesner, B. and Lorenz, D. and Theilig, F. and Schmitt, R. and Vossebein, L. and Tamma, G. and Beyermann, M. and Krause, E. and Herberg, F.W. and Valenti, G. and Bachmann, S. and Rosenthal, W. and Klussmann, E.
Journal of Biological Chemistry 279 (25): 26654-26665. 18 June 2004

The prostaglandin E2 analogue sulprostone antagonizes vasopressin-induced antidiuresis through activation of Rho.
Tamma, G. and Wiesner, B. and Furkert, J. and Hahm, D. and Oksche, A. and Schaefer, M. and Valenti, G. and Rosenthal, W. and Klussmann, E.
Journal of Cell Science 116 (Pt 16): 3285-3294. 15 August 2003

Renal expression of sodium transporters and aquaporin-2 in hypothyroid rats.
Schmitt, R. and Klussmann, E. and Kahl, T. and Ellison, D.H. and Bachmann, S.
American Journal of Physiology Renal Physiology 284 (5): F1097-F1104. May 2003

cAMP-induced AQP2 translocation is associated with RhoA inhibition through RhoA phosphorylation and interaction with RhoGDI.
Tamma, G. and Klussmann, E. and Procino, G. and Svelto, M. and Rosenthal, W. and Valenti, G.
Journal of Cell Science 116 (Pt 8): 1519-1525. 15 April 2003

Osmolality and solute composition are strong regulators of AQP2 expression in renal principal cells.
Storm, R. and Klussmann, E. and Geelhaar, A. and Rosenthal, W. and Maric, K.
American Journal of Physiology Renal Physiology 284 (1): F189-F198. January 2003

Rho inhibits cAMP-induced translocation of aquaporin-2 into the apical membrane of renal cells.
Tamma, G. and Klussmann, E. and Maric, K. and Aktories, K. and Svelto, M. and Rosenthal, W. and Valenti, G.
American Journal of Physiology Renal Physiology 281 (6): F1092-F1101. December 2001

Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling.
Klussmann, E. and Edemir, B. and Pepperle, B. and Tamma, G. and Henn, V. and Klauschenz, E. and Hundsrucker, C. and Maric, K. and Rosenthal, W.
FEBS Letters 507 (3): 264-268. 2 November 2001

Role and identification of protein kinase A anchoring proteins in vasopressin-mediated aquaporin-2 translocation.
Klussmann, E. and Rosenthal, W.
Kidney International 60 (2): 446-449. August 2001

An inhibitory role of Rho in the vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells.
Klussmann, E. and Tamma, G. and Lorenz, D. and Wiesner, B. and Maric, K. and Hofmann, F. and Aktories, K. and Valenti, G. and Rosenthal, W.
Journal of Biological Chemistry 276 (23): 20451-20457. 8 June 2001

Cell volume kinetics of adherent epithelial cells measured by laser scanning reflection microscopy: determination of water permeability changes of renal principal cells.
Maric, K. and Wiesner, B. and Lorenz, D. and Klussmann, E. and Betz, T. and Rosenthal, W.
Biophysical Journal 80 (4): 1783-1790. April 2001

Protein kinase A anchoring proteins are required for vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells.
Klussmann, E. and Maric, K. and Wiesner, B. and Beyermann, M. and Rosenthal, W.
Journal of Biological Chemistry 274 (8): 4934-4938. 19 February 1999

MUC2 gene suppression in human colorectal carcinomas and their metastases: in vitro evidence of the modulatory role of DNA methylation.
Hanski, C. and Riede, E. and Gratchev, A. and Foss, H.D. and Boehm, C. and Klussmann, E. and Hummel, M. and Mann, B. and Buhr, H.J. and Stein, H. and Kim, Y.S. and Gum, J. and Riecken, E.O.
Laboratory Investigation 77 (6): 685-695. December 1997

Low O-acetylation of sialyl-Le(x) contributes to its overexpression in colon carcinoma metastases.
Mann, B. and Klussmann, E. and Vandamme-Feldhaus, V. and Iwersen, M. and Hanski, M.L. and Riecken, E.O. and Buhr, H.J. and Schauer, R. and Kim, Y.S. and Hanski, C.
International Journal of Cancer 72 (2): 258-264. 17 July 1997

Fucosyltransferase III and sialyl-Le(x) expression correlate in cultured colon carcinoma cells but not in colon carcinoma tissue.
Hanski, C. and Klussmann, E. and Wang, J. and Boehm, C. and Ogorek, D. and Hanski, M.L. and Krueger-Krasagakes, S. and Eberle, J. and Schmitt-Graeff, A. and Riecken, E.O.
Glycoconjugate Journal 13 (5): 727-733. October 1996

Expression of MUC2-mucin in colorectal adenomas and carcinomas of different histological types.
Blanke, M. and Klussmann, E. and Krueger-Krasagakes, S. and Schmitt-Graeff, A. and Stolte, M. and Bornhoeft, G. and Stein, H. and Xing, P.X. and McKenzie, I.F. and Verstijnen, C.P. and Riecken, E.O. and Hanski, C.
International Journal of Cancer 59 (3): 301-306. 1 November 1994

Altered glycosylation of the MUC-1 protein core contributes to the colon carcinoma-associated increase of mucin-bound sialyl-Lewis(x) expression.
Hanski, C. and Drechsler, K. and Hanisch, F.G. and Sheehan, J. and Manske, M. and Ogorek, D. and Klussmann, E. and Hanski, M.L. and Blank, M. and Xing, P.X. and McKenzie, I.F.C. and Devine, P.L. and Riecken, E.O.
Cancer Research 53 (17): 4082-4088. 1 September 1993

Book Section

A-kinase anchoring proteins (AKAPs).
Walker-Gray, R. and Klussmann, E.
In: Encyclopedia of Molecular Pharmacology : Third Edition. Springer, Cham, 78-83. ISBN 978-3-030-57400-0 2021

A-kinase anchoring proteins (AKAPs).
Walker-Gray, R. and Klussmann, E.
In: Encyclopedia of Molecular Pharmacology. Springer, Cham, 1-7. ISBN 978-3-030-21573-6 2020

Pharmacological approaches for delineating functions of AKAP- based signalling complexes and finding therapeutic targets.
Schrade, K. and Klussmann, E.
In: Microdomains in the Cardiovascular System. Cardiac and Vascular Biology . Springer, Cham, Switzerland, 59-83. ISBN 978-3-319-54578-3 20 September 2017

Review

Local cyclic adenosine monophosphate signalling cascades - roles and targets in chronic kidney disease.
Sholokh, A. and Klussmann, E.
Acta Physiologica 232 (1): e13641. May 2021

Vasopressin-vermittelte Wasserrückresorption im Sammelrohr der Niere [Vasopressin-mediated water reabsorption in the renal collecting duct].
Baltzer, S. and Klussmann, E.
BIOspektrum 27 (2): 165-167. March 2021

New aspects in cardiac L-type Ca(2+) channel regulation.
Pallien, T. and Klussmann, E.
Biochemical Society Transactions 48 (1): 39-49. February 2020

Small molecules for modulating the localisation of the water channel aquaporin-2-disease relevance and perspectives for targeting local cAMP signalling.
Baltzer, S. and Klussmann, E.
Naunyn-Schmiedeberg's Archives of Pharmacology 392 (9): 1049-1064. September 2019

Roles of A-kinase anchoring proteins and phosphodiesterases in the cardiovascular system.
Ercu, M. and Klussmann, E.
Journal of Cardiovascular Development and Disease 5 (1): 14. 20 February 2018

Protein-protein interactions of PDE4 family members - Functions, interactions and therapeutic value.
Klussmann, E.
Cellular Signalling 28 (7): 713-718. July 2016

The trafficking of the water channel aquaporin-2 in renal principal cells-a potential target for pharmacological intervention in cardiovascular diseases.
Vukićević, T. and Schulz, M. and Faust, D. and Klussmann, E.
Frontiers in Pharmacology 7 : 23. 11 February 2016

Pharmacological targeting of AKAP-directed compartmentalized cAMP signalling.
Dema, A. and Perets, E. and Schulz, M.S. and Deák, V.A. and Klussmann, E.
Cellular Signalling 27 (12): 2474-2487. December 2015

A-kinase anchoring proteins as potential drug targets.
Troeger, J. and Moutty, M.C. and Skroblin, P. and Klussmann, E.
British Journal of Pharmacology 166 (2): 420-433. May 2012

Functional significance of cleavable signal peptides of G protein-coupled receptors.
Schuelein, R. and Westendorf, C. and Krause, G. and Rosenthal, W.
European Journal of Cell Biology 91 (4): 294-299. April 2012

Mechanisms of protein kinase A anchoring.
Skroblin, P. and Grossmann, S. and Schaefer, G. and Rosenthal, W. and Klussmann, E.
International Review of Cell and Molecular Biology 283 (C): 235-330. 2010

Regulation of aquaporin-2 trafficking.
Nedvetsky, P.I. and Tamma, G. and Beulshausen, S. and Valenti, G. and Rosenthal, W. and Klussmann, E.
Handbook of Experimental Pharmacology 190 (II): 133-157. 2009

Compartmentalized cAMP signalling in regulated exocytic processes in non-neuronal cells.
Szaszak, M. and Christian, F. and Rosenthal, W. and Klussmann, E.
Cellular Signalling 20 (4): 590-601. April 2008

Direct AKAP-mediated protein-protein interactions as potential drug targets.
Hundsrucker, C. and Klussmann, E.
Handbook of Experimental Pharmacology 186 : 483-503. 2008

Protein-protein interactions as target for new therapeutic molecules.
Klussmann, E.
BIOforum Europe 3 : 18-19. 2007

AKAP7.
Klussmann, E. and Rosenthal, W.
UCSD Nature Molecule Pages 4 April 2006

The mechanisms of aquaporin control in the renal collecting duct.
Klussmann, E. and Maric, K. and Rosenthal, W.
Reviews of Physiology Biochemistry and Pharmacology 141 : 33-95. 2000

Editorial

The role of AKAP12 in coordination of VEGF-induced endothelial cell motility.
Walker-Gray, R. and Klussmann, E.
Acta Physiologica 228 (1): e13359. January 2020

The Case : a handful of hypertension.
van den Born, B.J.H. and Oskam, L.C. and Zidane, M. and Schaechterle, C. and Klussmann, E. and Baehring, S. and Luft, F.C.
Kidney International 90 (4): 911-913. October 2016

First international meeting on anchored cAMP signaling pathways, Biomedical Campus, Berlin-Buch, Germany, 15-16 October 2005.
Klussmann, E.
European Journal of Cell Biology 85 (7): 581-584. 5 July 2006

Preprint

Reconstitution of β-adrenergic regulation of Ca(V)1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.
Katz, M. and Subramaniam, S. and Chomsky-Hecht, O. and Tsemakhovich, V. and Belkacemi, A. and Flockerzi, V. and Klussmann, E. and Hirsch, J. and Weiss, S. and Dascal, N.
bioRxiv : 2020.11.30.403964. 1 December 2020

Wnt11/Fzd7 signaling compartmentalizes AKAP2/PKA to regulate L-type Ca(2+) channel.
Csalyi, K.D. and Rharass, T. and Schulz, M. and Phan, M.H.Q. and Wakula, P. and Mhatre, K.N. and Plotnick, D. and Werdich, A.A. and Zauber, H. and Sury, M.D. and Selbach, M. and Heinzel, F.R. and Klussmann, E. and Panakova, D.
bioRxiv : 741637. 20 August 2019

Endothelial PKA targets ATG16L1 to regulate angiogenesis by limiting autophagy.
Zhao, X. and Nedvetsky, P. and Vion, A.C. and Popp, O. and Zühlke, K. and Dittmar, G. and Klussmann, E. and Gerhardt, H.
bioRxiv : 573683. 12 March 2019

This list was generated on Wed Nov 30 02:18:56 2022 CET.
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