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Blood Advances

Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis.
Kurtova, A.V. and Heinlein, M. and Haas, S. and Velten, L. and Dijkgraaf, G.J.P. and Storm, E.E. and Kljavin, N.M. and Boumahdi, S. and Himmels, P. and Herault, A. and Mancini, A.G. and Koeppen, H. and Dail, M. and Yan, M. and Zhang, J. and Koch, U. and Radtke, F. and Modrusan, Z. and Metcalfe, C. and Piskol, R. and de Sauvage, F.J.
Blood Advances 7 (4): 491-507. 28 February 2023

A complex proinflammatory cascade mediates the activation of HSCs upon LPS exposure in vivo.
Demel, U.M. and Lutz, R. and Sujer, S. and Demerdash, Y. and Sood, S. and Grünschläger, F. and Kuck, A. and Werner, P. and Blaszkiewicz, S. and Uckelmann, H.J. and Haas, S. and Essers, M.
Blood Advances 6 (11): 3513-3528. 10 June 2022

Cancer Cell

Cellular hierarchies predict drug response in acute myeloid leukemia.
Raffel, S. and Velten, L. and Haas, S.
Cancer Cell 40 (9): 917-919. 12 September 2022

Cell

The cycling and aging mouse female reproductive tract at single-cell resolution.
Winkler, I. and Tolkachov, A. and Lammers, F. and Lacour, P. and Daugelaite, K. and Schneider, N. and Koch, M.L. and Panten, J. and Grünschläger, F. and Poth, T. and Ávila, B.M.d. and Schneider, A. and Haas, S. and Odom, D.T. and Gonçalves, Â.
Cell 187 (4): 981-998.e25. 15 February 2024

Cancer stem cells: The adventurous journey from hematopoietic to leukemic stem cells.
Trumpp, A. and Haas, S.
Cell 185 (8): 1266-1270. 14 April 2022

Myc depletion induces a pluripotent dormant state mimicking diapause.
Scognamiglio, R. and Cabezas-Wallscheid, N. and Thier, M.C. and Altamura, S. and Reyes, A. and Prendergast, Á.M. and Baumgärtner, D. and Carnevalli, L.S. and Atzberger, Ann and Haas, S. and von Paleske, L. and Boroviak, T. and Wörsdörfer, P. and Essers, M.A.G. and Kloz, U. and Eisenman, R.N. and Edenhofer, F. and Bertone, P. and Huber, W. and van der Hoeven, F. and Smith, A. and Trumpp, A.
Cell 164 (4): 668-680. 11 February 2016

Transcriptional heterogeneity and lineage commitment in myeloid progenitors.
Paul, F. and Arkin, Y. and Giladi, A. and Jaitin, D.A. and Kenigsberg, E. and Keren-Shaul, H. and Winter, D. and Lara-Astiaso, D. and Gury, M. and Weiner, A. and David, E. and Cohen, N. and Lauridsen, F.K.B. and Haas, S. and Schlitzer, A. and Mildner, A. and Ginhoux, F. and Jung, S. and Trumpp, A. and Porse, B.T. and Tanay, A. and Amit, I.
Cell 163 (7): 1663-1677. 17 December 2015

Braveheart, a long noncoding RNA required for cardiovascular lineage commitment.
Klattenhoff, C.A. and Scheuermann, J.C. and Surface, L.E. and Bradley, R.K. and Fields, P.A. and Steinhauser, M.L. and Ding, H. and Butty, V.L. and Torrey, L. and Haas, S. and Abo, R. and Tabebordbar, M. and Lee, R.T. and Burge, C.B. and Boyer, L.A.
Cell 152 (3): 570-83. 31 January 2013

Cell Cycle

Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing.
Lipka, D.B. and Wang, Q. and Cabezas-Wallscheid, N. and Klimmeck, D. and Weichenhan, D. and Herrmann, C. and Lier, A. and Brocks, D. and von Paleske, L. and Renders, S. and Wünsche, P. and Zeisberger, P. and Gu, L. and Haas, S. and Essers, M.A. and Brors, B. and Eils, R. and Trumpp, A. and Milsom, M.D. and Plass, C.
Cell Cycle 13 (22): 3476-3487. 10 December 2014

Cell Death & Disease

The traditional Chinese medical compound Rocaglamide protects nonmalignant primary cells from DNA damage-induced toxicity by inhibition of p53 expression.
Becker, M.S. and Schmezer, P. and Breuer, R. and Haas, S.F. and Essers, M.A. and Krammer, P.H. and Li-Weber, M.
Cell Death & Disease 5 : e1000. January 2014

Cell Reports

Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer.
Saini, M. and Schmidleitner, L. and Moreno, H.D. and Donato, E. and Falcone, M. and Bartsch, J.M. and Vogel, V. and Würth, R. and Pfarr, N. and Espinet, E. and Lehmann, M. and Königshoff, M. and Reitberger, M. and Haas, S. and Graf, E. and Schwarzmayr, T. and Strom, T.M. and Spaich, S. and Sütterlin, M. and Schneeweiss, A. and Weichert, W. and Schotta, G. and Reichert, M. and Aceto, N. and Sprick, M.R. and Trumpp, A. and Scheel, C.H. and Klein, C.
Cell Reports 42 (6): 112533. 27 June 2023

Systemic virus infections differentially modulate cell cycle state and functionality of long-term hematopoietic stem cells in vivo.
Hirche, C. and Frenz, T. and Haas, S.F. and Döring, M. and Borst, K. and Tegtmeyer, P.K. and Brizic, I. and Jordan, S. and Keyser, K. and Chhatbar, C. and Pronk, E. and Lin, S. and Messerle, M. and Jonjic, S. and Falk, C.S. and Trumpp, A. and Essers, M.A.G. and Kalinke, U.
Cell Reports 19 (11): 2345-2356. 13 June 2017

Cell Stem Cell

Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia.
Beneyto-Calabuig, S. and Merbach, A.K. and Kniffka, J.A. and Antes, M. and Szu-Tu, C. and Rohde, C. and Waclawiczek, A. and Stelmach, P. and Gräßle, S. and Pervan, P. and Janssen, M. and Landry, J.J.M. and Benes, V. and Jauch, A. and Brough, M. and Bauer, M. and Besenbeck, B. and Felden, J. and Bäumer, S. and Hundemer, M. and Sauer, T. and Pabst, C. and Wickenhauser, C. and Angenendt, L. and Schliemann, C. and Trumpp, A. and Haas, S. and Scherer, M. and Raffel, S. and Müller-Tidow, C. and Velten, L.
Cell Stem Cell 30 (5): 706-721. 4 May 2023

Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging.
Bogeska, R. and Mikecin, A.M. and Kaschutnig, P. and Fawaz, M. and Büchler-Schäff, M. and Le, D. and Ganuza, M. and Vollmer, A. and Paffenholz, S.V. and Asada, N. and Rodriguez-Correa, E. and Frauhammer, F. and Buettner, F. and Ball, M. and Knoch, J. and Stäble, S. and Walter, D. and Petri, A. and Carreño-Gonzalez, M.J. and Wagner, V. and Brors, B. and Haas, S. and Lipka, D.B. and Essers, M.A.G. and Weru, V. and Holland-Letz, T. and Mallm, J.P. and Rippe, K. and Krämer, S. and Schlesner, M. and McKinney Freeman, S. and Florian, M.C. and King, K.Y. and Frenette, P.S. and Rieger, M.A. and Milsom, M.D.
Cell Stem Cell 29 (8): 1273-1284. 4 August 2022

Antigen presentation safeguards the integrity of the hematopoietic stem cell pool.
Hernández-Malmierca, P. and Vonficht, D. and Schnell, A. and Uckelmann, H.J. and Bollhagen, A. and Mahmoud, M.A.A. and Landua, S.L. and van der Salm, E. and Trautmann, C. and Raffel, S. and Grünschläger, F. and Lutz, R. and Ghosh, M. and Renders, S. and Correia, N. and Donato, E. and Dixon, K.O. and Hirche, C. and Andresen, C. and Robens, Cl. and Werner, P.S. and Boch, T. and Eisel, D. and Osen, W. and Pilz, F. and Przybylla, A. and Klein, C. and Buchholz, F. and Milsom, M.D. and Essers, M.A.G. and Eichmüller, S.B. and Hofmann, W.K. and Nowak, D. and Hübschmann, D. and Hundemer, M. and Thiede, C. and Bullinger, L. and Müller-Tidow, C. and Armstrong, S.A. and Trumpp, A. and Kuchroo, V.K. and Haas, S.
Cell Stem Cell 29 (5): 760-775. 5 May 2022

Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging.
Young, K. and Eudy, E. and Bell, R. and Loberg, M.A. and Stearns, T. and Sharma, D. and Velten, L. and Haas, S. and Filippi, M.D. and Trowbridge, J.J.
Cell Stem Cell 28 (8): 1473-1482. 5 August 2021

Causes and consequences of hematopoietic stem cell heterogeneity.
Haas, S. and Trumpp, A. and Milsom, M.D.
Cell Stem Cell 22 (5): 627-638. 3 May 2018

Inflammation-induced emergency megakaryopoiesis driven by hematopoietic stem cell-like megakaryocyte progenitors.
Haas, S. and Hansson, J. and Klimmeck, D. and Loeffler, D. and Velten, L. and Uckelmann, H. and Wurzer, S. and Prendergast, Á.M. and Schnell, A. and Hexel, K. and Santarella-Mellwig, R. and Blaszkiewicz, S. and Kuck, A. and Geiger, H. and Milsom, M.D. and Steinmetz, L.M. and Schroeder, T. and Trumpp, A. and Krijgsveld, J. and Essers, M.A.G.
Cell Stem Cell 17 (4): 422-34. 1 October 2015

Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis.
Cabezas-Wallscheid, N. and Klimmeck, D. and Hansson, J. and Lipka, D.B. and Reyes, A. and Wang, Q. and Weichenhan, D. and Lier, A. and von Paleske, L. and Renders, S. and Wünsche, P. and Zeisberger, P. and Brocks, D. and Gu, L. and Herrmann, C. and Haas, S. and Essers, M.A.G. and Brors, B. and Eils, R. and Huber, W. and Milsom, M.D. and Plass, C. and Krijgsveld, J. and Trumpp, A.
Cell Stem Cell 15 (4): 507-522. 2 October 2014

Current Opinion in Oncology

Single-cell and spatial transcriptomics approaches of the bone marrow microenvironment.
Al-Sabah, J. and Baccin, C. and Haas, S.
Current Opinion in Oncology 32 (2): 146-153. 1 March 2020

Current Stem Cell Reports

Hematopoietic stem cells in health and disease - insights from single-cell multi-omic approaches.
Haas, S.
Current Stem Cell Reports 6 (3): 67-76. September 2020

Developmental Cell

Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice.
Funk, M.C. and Gleixner, J.G. and Heigwer, F. and Vonficht, D. and Valentini, E. and Aydin, Z. and Tonin, E. and Del Prete, S. and Mahara, S. and Throm, Y. and Hetzer, J. and Heide, D. and Stegle, O. and Odom, D.T. and Feldmann, A. and Haas, S. and Heikenwalder, M. and Boutros, M.
Developmental Cell 58 (24): 2914-2929. 18 December 2023

An intrinsic interferon program protects stem cells from viral infection.
Haas, S. and Trumpp, A.
Developmental Cell 44 (3): 279-280. 5 February 2018

Experimental Hematology

Single-cell lineage tracing approaches in hematology research: technical considerations.
Carrelha, J. and Lin, D.S. and Rodriguez-Fraticelli, A.E. and Luis, T.C. and Wilkinson, A.C. and Cabezas-Wallscheid, N. and Tremblay, C.S. and Haas, S.
Experimental Hematology 89 : 26-36. September 2020

Lineage commitment of hematopoietic stem cells and progenitors: insights from recent single cell and lineage tracing technologies.
Loughran, S.J. and Haas, S. and Wilkinson, A.C. and Klein, A.M. and Brand, M.
Experimental Hematology 88 : 1-6. August 2020

Technical considerations for the use of CRISPR/Cas9 in hematology research.
Gundry, M.C. and Dever, D.P. and Yudovich, D. and Bauer, D.E. and Haas, S. and Wilkinson, A.C. and Singbrant, S.
Experimental Hematology 54 : 4-11. October 2017

Frontiers in Immunology

Identification of drug candidates targeting monocyte reprogramming in people living with HIV.
Knoll, R. and Bonaguro, L. and Dos Santos, J.C. and Warnat-Herresthal, S. and Jacobs-Cleophas, M.C.P. and Blümel, E. and Reusch, N. and Horne, A. and Herbert, M. and Nuesch-Germano, M. and Otten, T. and van der Heijden, W.A. and van de Wijer, L. and Shalek, A.K. and Händler, K. and Becker, M. and Beyer, M.D. and Netea, M.G. and Joosten, L.A.B. and van der Ven, A.J.A.M. and Schultze, J.L. and Aschenbrenner, A.C.
Frontiers in Immunology 14 : 1275136. 20 November 2023

Single-cell clonal tracking of persistent T-cells in allogeneic hematopoietic stem cell transplantation.
Obermayer, B. and Keilholz, L. and Conrad, T. and Frentsch, M. and Blau, I.W. and Vuong, L. and Lesch, S. and Movasshagi, K. and Tietze-Stolley, C. and Loyal, L. and Henze, L. and Penack, O. and Stervbo, U. and Babel, N. and Haas, S. and Beule, D. and Bullinger, L. and Wittenbecher, Friedrich and Na, I.K.
Frontiers in Immunology 14 : 1114368. 10 February 2023

Haematologica

Small molecule SUMO inhibition for biomarker-informed B-cell lymphoma therapy.
Demel, U.M. and Wirth, M. and Yousefian, S. and Zhang, L. and Isaakidis, K. and Dönig, J. and Böger, M. and Singh, N. and Köse, H. and Haas, S. and Müller, S. and Schick, M. and Keller, U.
Haematologica 108 (2): 555-567. February 2023

IFNα-mediated remodeling of endothelial cells in the bone marrow niche.
Prendergast, Á.M. and Kuck, A. and van Essen, M. and Haas, S. and Blaszkiewicz, S. and Essers, M.A.G.
Haematologica 102 (3): 445-453. March 2017

Journal of Clinical Investigation

Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer.
Demel, U.M. and Böger, M. and Yousefian, S. and Grunert, C. and Zhang, L. and Hotz, P.W. and Gottschlich, A. and Köse, H. and Isaakidis, K. and Vonficht, D. and Grünschläger, F. and Rohleder, E. and Wagner, K. and Dönig, J. and Igl, V. and Brzezicha, B. and Baumgartner, F. and Habringer, S. and Löber, J. and Chapuy, B. and Weidinger, C. and Kobold, S. and Haas, S. and Busse, A.B. and Müller, S. and Wirth, M. and Schick, M. and Keller, U.
Journal of Clinical Investigation 132 (9): e152383. 2 May 2022

Journal of Experimental Medicine

Extracellular matrix protein Matrilin-4 regulates stress-induced HSC proliferation via CXCR4.
Uckelmann, H. and Blaszkiewicz, S. and Nicolae, C. and Haas, S. and Schnell, A. and Wurzer, S. and Wagener, R. and Aszodi, A. and Essers, M.A.G.
Journal of Experimental Medicine 213 (10): 1961-1971. 19 September 2016

Journal of Hematology & Oncology

Treatment of adult ALL patients with third-generation CD19-directed CAR T cells: results of a pivotal trial.
Schubert, M.L. and Schmitt, A. and Hückelhoven-Krauss, A. and Neuber, B. and Kunz, A. and Waldhoff, P. and Vonficht, D. and Yousefian, S. and Jopp-Saile, L. and Wang, L. and Korell, F. and Keib, A. and Michels, B. and Haas, D. and Sauer, T. and Derigs, P. and Kulozik, A. and Kunz, J. and Pavel, P. and Laier, S. and Wuchter, P. and Schmier, J. and Bug, G. and Lang, F. and Gökbuget, N. and Casper, J. and Görner, M. and Finke, J. and Neubauer, A. and Ringhoffer, M. and Wolleschak, D. and Brüggemann, M. and Haas, S. and Ho, A.D. and Müller-Tidow, C. and Dreger, P. and Schmitt, M.
Journal of Hematology & Oncology 16 (1): 79. 22 July 2023

Leukemia

Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia.
Eifert, T. and Hsu, C.J. and Becker, A.L. and Graessle, S. and Horne, A. and Bemmann, F. and Zhang, Q. and Heuser, M. and Vasioukhin, V. and Scholl, S. and Hochhaus, A. and Siegerist, F. and Endlich, N. and Bullinger, L. and Lane, S.W. and Haas, S. and Schnoeder, T.M and Heidel, F.H.
Leukemia 37 (10): 2027-2035. October 2023

Life Science Alliance

Single-cell time series analysis reveals the dynamics of HSPC response to inflammation.
Bouman, B.J. and Demerdash, Y. and Sood, S. and Grünschläger, F. and Pilz, F. and Itani, A.R. and Kuck, A. and Marot-Lassauzaie, V. and Haas, S. and Haghverdi, L. and Essers, M.A.
Life Science Alliance 7 (3): e202302309. March 2024

Methods in Molecular Biology

Analysis of single-cell transcriptome data in drosophila.
Yousefian, S. and Musillo, M.J. and Bageritz, J.
Methods in Molecular Biology 2540 (3): 93-111. 19 August 2022

Molecular Cell

ATACing single cells with phages.
Maschmeyer, P. and Haas, S.
Molecular Cell 82 (2): 234-236. 20 January 2022

Nature Cell Biology

Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization.
Baccin, C. and Al-Sabah, J. and Velten, L. and Helbling, P.M. and Grünschläger, F. and Hernández-Malmierca, P. and Nombela-Arrieta, C. and Steinmetz, L.M. and Trumpp, A. and Haas, S.
Nature Cell Biology 22 (1): 38-48. January 2020

Human haematopoietic stem cell lineage commitment is a continuous process.
Velten, L. and Haas, S.F. and Raffel, S. and Blaszkiewicz, S. and Islam, S. and Hennig, B.P. and Hirche, C. and Lutz, C. and Buss, E.C. and Nowak, D. and Boch, T. and Hofmann, W.K. and Ho, A.D. and Huber, W. and Trumpp, A. and Essers, M.A.G. and Steinmetz, L.M.
Nature Cell Biology 19 (4): 271-281. April 2017

Nature Communications

Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level.
John, L. and Poos, A.M. and Brobeil, A. and Schinke, C. and Huhn, S. and Prokoph, N. and Lutz, R. and Wagner, B. and Zangari, M. and Tirier, S.M. and Mallm, J.P. and Schumacher, S. and Vonficht, D. and Solé-Boldo, L. and Quick, S. and Steiger, S. and Przybilla, M.J. and Bauer, K. and Baumann, A. and Hemmer, S. and Rehnitz, C. and Lückerath, C. and Sachpekidis, C. and Mechtersheimer, G. and Haberkorn, U. and Dimitrakopoulou-Strauss, A. and Reichert, P. and Barlogie, B. and Müller-Tidow, C. and Goldschmidt, H. and Hillengass, J. and Rasche, L. and Haas, S.F. and van Rhee, F. and Rippe, K. and Raab, M.S. and Sauer, S. and Weinhold, N.
Nature Communications 14 (1): 5011. 17 August 2023

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.
Velten, L. and Story, B.A. and Hernández-Malmierca, P. and Raffel, S. and Leonce, D.R. and Milbank, J. and Paulsen, M. and Demir, A. and Szu-Tu, C. and Frömel, R. and Lutz, C. and Nowak, D. and Jann, J.C. and Pabst, C. and Boch, T. and Hofmann, W.K. and Müller-Tidow, C. and Trumpp, A. and Haas, S. and Steinmetz, L.M.
Nature Communications 12 (1): 1366. 1 March 2021

Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone.
Lutsik, P. and Baude, A. and Mancarella, D. and Öz, S. and Kühn, A. and Toth, R. and Hey, J. and Toprak, U.H. and Lim, J. and Nguyen, V.H. and Jiang, C. and Mayakonda, A. and Hartmann, M. and Rosemann, F. and Breuer, K. and Vonficht, D. and Grünschläger, F. and Lee, S. and Schuhmacher, M.K. and Kusevic, D. and Jauch, A. and Weichenhan, D. and Zustin, J. and Schlesner, M. and Haas, S. and Park, J.H. and Park, Y.J. and Oppermann, U. and Jeltsch, A. and Haller, F. and Fellenberg, J. and Lindroth, A.M. and Plass, C.
Nature Communications 11 (1): 5414. 27 October 2020

Nature Genetics

Systematic perturbation of chromatin factors identifies regulatory networks during healthy and malignant hematopoiesis.
Solé-Boldo, L. and Haas, S.
Nature Genetics 55 (9): 1430-1431. September 2023

DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats.
Brocks, D. and Schmidt, C.R. and Daskalakis, M. and Jang, H.S. and Shah, N.M. and Li, D. and Li, J. and Zhang, B. and Hou, Y. and Laudato, S. and Lipka, D.B. and Schott, J. and Bierhoff, H. and Assenov, Y. and Helf, M. and Ressnerova, A. and Islam, M.S. and Lindroth, A.M. and Haas, S. and Essers, M. and Imbusch, C.D. and Brors, B. and Oehme, I. and Witt, O. and Lübbert, M. and Mallm, J.P. and Rippe, K. and Will, R. and Weichenhan, D. and Stoecklin, G. and Gerhäuser, C. and Oakes, C.C. and Wang, T. and Plass, C.
Nature Genetics 49 (7): 1052-1060. July 2017

Nature Immunology

Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states.
Triana, S. and Vonficht, D. and Jopp-Saile, L. and Raffel, S. and Lutz, R. and Leonce, D. and Antes, M. and Hernández-Malmierca, P. and Ordoñez-Rueda, D. and Ramasz, B. and Boch, T. and Jann, J.C. and Nowak, D. and Hofmann, W.K. and Müller-Tidow, C. and Hübschmann, D. and Alexandrov, T. and Benes, V. and Trumpp, A. and Paulsen, M. and Velten, L. and Haas, S.
Nature Immunology 22 (12): 1577-1589. December 2021

bioRxiv

Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states.
Triana, S.H. and Vonficht, D. and Jopp-Saile, L. and Raffel, S. and Lutz, R. and Leonce, D. and Ordoñez-Rueda, D. and Ramasz, B. and Boch, T. and Jann, J.C. and Nowak, D. and Hofmann, W.K. and Müller-Tidow, C. and Hübschmann, D. and Alexandrov, T. and Benes, V. and Trumpp, A. and Paulsen, M. and Velten, L. and Haas, S.
bioRxiv : 2021.03.18.435922. 2 September 2021

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