Article
Sequential changes in calcium transients during M phase regulate cardiomyocyte proliferation.
Liu, Honghai 
ORCID: https://orcid.org/0000-0002-0693-6083, Ammanamanchi, Niyatie ORCID: https://orcid.org/0000-0002-9335-3512, Mich-Basso, Jocelyn D. ORCID: https://orcid.org/0009-0003-1316-6851, Panama, Brian K. ORCID: https://orcid.org/0009-0004-9627-2576, Li, Yao ORCID: https://orcid.org/0000-0002-7872-1495, Huang, Winston ORCID: https://orcid.org/0009-0009-6289-3928, Almeida, Dena ORCID: https://orcid.org/0000-0002-7286-2027, Lewarchik, Christopher M., Lo, Brendan ORCID: https://orcid.org/0009-0006-8766-1881, Wu, Yijen ORCID: https://orcid.org/0000-0001-9509-5417, Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172, Kotlikoff, Michael I. ORCID: https://orcid.org/0000-0001-9879-1899, Baehr, Wolfgang ORCID: https://orcid.org/0000-0001-5003-9550, Rasmusson, Randall ORCID: https://orcid.org/0009-0005-6641-7209, Salama, Guy ORCID: https://orcid.org/0000-0002-5306-8178 and Kühn, Bernhard ORCID: https://orcid.org/0000-0002-1855-7072
Journal of Cell Biology 225
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3 August 2026
Targeting intracellular cholesterol imbalance rescues sarcomere–ER contact site signaling and ER remodeling in dilated cardiomyopathy.
Ignatyeva, Nadezda, Cheruiyot, Cleophas, Saleem, Hafiza Nosheen, Wali, Ruheen, Plota, Daria, Zhang, Wenjing, Schön, Sophie, Brandenburg, Soeren, Yang, Zhengyi ORCID: https://orcid.org/0000-0001-7190-7505, Steyer, Anna ORCID: https://orcid.org/0000-0002-4814-7517, Urlaub, Henning, Rasmussen, Torsten, Mogensen, Jens, Pronto, Julius Ryan D., Döring, Yannic ORCID: https://orcid.org/0000-0001-5060-8610, Radke, Michael H. ORCID: https://orcid.org/0000-0003-0112-9917, Shcherbata, Halyna ORCID: https://orcid.org/0000-0002-3855-0345, Lehnart, Stephan E. ORCID: https://orcid.org/0000-0002-8115-3513, Janshoff, Andreas, Sossalla, Samuel ORCID: https://orcid.org/0000-0001-8034-2673, Ruhwedel, Torben ORCID: https://orcid.org/0000-0002-9535-9395, Moebius, Wiebke ORCID: https://orcid.org/0000-0002-2902-7165, Toischer, Karl, Brügger, Britta ORCID: https://orcid.org/0000-0002-3477-8270, Haucke, Volver ORCID: https://orcid.org/0000-0003-3119-6993, Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172, Voigt, Niels ORCID: https://orcid.org/0000-0001-8230-2341 and Ebert, Antje ORCID: https://orcid.org/0000-0002-3642-242X
Signal Transduction and Targeted Therapy 11
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17 June 2026
RBM20 isoform regulation by independent transcription start sites adapts alternative splicing in development and disease.
Radke, Michael H. ORCID: https://orcid.org/0000-0003-0112-9917, Badillo Lisakowski, Victor ORCID: https://orcid.org/0000-0001-5906-2589, Meinke, Stefan ORCID: https://orcid.org/0000-0001-5083-3383, Britto-Borges, Thiago, Schneider-Lunitz, Valentin ORCID: https://orcid.org/0000-0002-3980-3789, Hummel, Oliver ORCID: https://orcid.org/0009-0000-9986-8333, van Heesch, Sebastiaan ORCID: https://orcid.org/0000-0001-9593-1980, Ruiz Orera, Jorge ORCID: https://orcid.org/0000-0002-8317-0034, Hubner, Norbert ORCID: https://orcid.org/0000-0002-1218-6223, Granzier, Henk ORCID: https://orcid.org/0000-0002-9516-407X, Dieterich, Christoph ORCID: https://orcid.org/0000-0001-9468-6311 and Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172
Nature Communications 17
(1): 4607.
23 May 2026
Novel truncating variant c.1222DupC in RBM20 causes cardiomyopathy consistent with haploinsufficiency.
Pant, Priyanka ORCID: https://orcid.org/0009-0003-3271-3259, Huang, Yong ORCID: https://orcid.org/0009-0000-6727-4960, Ghouse, Zakiya ORCID: https://orcid.org/0009-0009-7584-202X, Bai, Fang ORCID: https://orcid.org/0000-0003-0639-8104, Kemmling, Elena ORCID: https://orcid.org/0009-0001-4952-306X, Konrad, Laura ORCID: https://orcid.org/0009-0008-4700-7433, Alameldeen, Ahmed ORCID: https://orcid.org/0000-0002-0026-7501, Kistler, Rebecca, Seeger, Timon, Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172, Parikh, Victoria N. ORCID: https://orcid.org/0000-0002-5138-5559 and van den Hoogenhof, Maarten M.G. ORCID: https://orcid.org/0000-0003-2768-3457
Circulation Genomic and Precision Medicine
: e005471.
30 April 2026
(In Press)
Alternative splicing dynamics during human cardiac development in vivo and in vitro.
Gomes-Silva, Beatriz, Furtado, Marta ORCID: https://orcid.org/0000-0003-3714-9653, Ribeiro, Marta, Martins, Sandra, Carvalho, Teresa, Ventura-Gomes, André, Maatz, Henrike ORCID: https://orcid.org/0000-0002-9232-6272, Parakkat, Pragati ORCID: https://orcid.org/0000-0003-2691-791X, Crocini, Claudia, Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172, Savisaar, Rosina and Carmo-Fonseca, Maria ORCID: https://orcid.org/0000-0002-3402-7143
Stem Cell Reports 21
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13 January 2026
Prime editing corrects the dilated cardiomyopathy causing RBM20-P633L-mutation in human cardiomyocytes.
Roman, Alexandra ORCID: https://orcid.org/0000-0001-9440-9752, Zimmer, Anja, Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172, Steinmetz, Lars M., Kühn, Ralf ORCID: https://orcid.org/0000-0003-1694-9803 and Dang, Tu ORCID: https://orcid.org/0009-0001-0138-7599
Molecular Therapy Nucleic Acids 36
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9 December 2025
Deep phenotyping of heart failure with preserved ejection fraction through multi-omics integration.
Versnjak, Jakob ORCID: https://orcid.org/0009-0009-6179-1014, Kuehne, Titus ORCID: https://orcid.org/0000-0003-1631-4824, Fahjen, Pauline ORCID: https://orcid.org/0000-0002-5015-0643, Jovanovic, Nina ORCID: https://orcid.org/0000-0001-6300-9705, Löber, Ulrike ORCID: https://orcid.org/0000-0001-7468-9531, Schiattarella, Gabriele G. ORCID: https://orcid.org/0000-0002-7582-7171, Wilck, Nicola ORCID: https://orcid.org/0000-0003-3189-5364, Gerhardt, Holger ORCID: https://orcid.org/0000-0002-3030-0384, Müller, Dominik N. ORCID: https://orcid.org/0000-0003-3650-5644, Edelmann, Frank ORCID: https://orcid.org/0000-0003-4401-5936, Mertins, Philipp ORCID: https://orcid.org/0000-0002-2245-528X, Eils, Roland ORCID: https://orcid.org/0000-0002-0034-4036, Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172, Forslund, Sofia K. ORCID: https://orcid.org/0000-0003-4285-6993, Wild, Benjamin ORCID: https://orcid.org/0000-0002-7492-8448 and Kelm, Marcus ORCID: https://orcid.org/0000-0003-4971-0452
European Journal of Heart Failure 27
(12): 3243-3259.
December 2025
Rbm20 antisense oligonucleotides alleviate diastolic dysfunction in a mouse model of cardiometabolic heart failure (HFpEF).
Methawasin, Mei, Meinke, Stefan ORCID: https://orcid.org/0000-0001-5083-3383, Radke, Michael H. ORCID: https://orcid.org/0000-0003-0112-9917, Farman, Gerrie P., Hourani, Zaynab, Smith 3rd, John E., Guo, Wei, Granzier, Henk ORCID: https://orcid.org/0000-0002-9516-407X and Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172
Cardiovascular Research 121
(13): 2027-2041.
October 2025
Stochastic model of IP3-induced Ca2+ spiking of HEK293 cells.
Azzoni, Caterina ORCID: https://orcid.org/0009-0009-4926-3534, Jüttner, Rene ORCID: https://orcid.org/0000-0003-3565-0698, Sporbert, Anje ORCID: https://orcid.org/0000-0002-3738-1295, Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172, Roderick, H. Llewelyn and Falcke, Martin ORCID: https://orcid.org/0000-0001-7137-1114
PLoS Computational Biology 21
(8): e1013322.
August 2025
Visualizing sarcomere and cellular dynamics in skeletal muscle to improve cell therapies.
Hüttemeister, J., Rudolph, F., Radke, M.H. ORCID: https://orcid.org/0000-0003-0112-9917, Fink, C., Friedrich, D. ORCID: https://orcid.org/0000-0003-2144-9280, Preibisch, S. ORCID: https://orcid.org/0000-0002-0276-494X, Falcke, M. ORCID: https://orcid.org/0000-0001-7137-1114, Wagner, E., Lehnart, S.E. ORCID: https://orcid.org/0000-0002-8115-3513 and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
eLife 13
: e95597.
17 December 2024
Titin's cardiac-specific N2B element is critical to mechanotransduction during volume overload of the heart.
Strom, J., Bull, M., Gohlke, J., Saripalli, C., Methawasin, M., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172 and Granzier, H.
Journal of Molecular and Cellular Cardiology 191
: 40-49.
June 2024
Loss of cardiac splicing regulator RBM20 is associated with early-onset atrial fibrillation.
Vad, O.B., Angeli, E., Liss, M. ORCID: https://orcid.org/0000-0002-0585-7850, Ahlberg, G., Andreasen, L., Christophersen, I.E., Hansen, C.C., Møller, S. ORCID: https://orcid.org/0000-0002-3714-2227, Hellsten, Y., Haunsoe, S., Tveit, A., Svendsen, J.H., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Lundegaard, P.R. ORCID: https://orcid.org/0000-0002-8284-1844 and Olesen, M.S.
JACC: Basic to Translational Science 9
(2): 163-180.
February 2024
Mislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3.
Kornienko, J. ORCID: https://orcid.org/0000-0002-7876-230X, Rodríguez-Martínez, M., Fenzl, K. ORCID: https://orcid.org/0000-0001-8097-7740, Hinze, F., Schraivogel, D., Grosch, M. ORCID: https://orcid.org/0000-0001-9016-8920, Tunaj, B., Lindenhofer, D. ORCID: https://orcid.org/0000-0001-8838-7163, Schraft, L. ORCID: https://orcid.org/0009-0005-4504-8926, Kueblbeck, M., Smith, E. ORCID: https://orcid.org/0000-0002-5915-9492, Mao, C. ORCID: https://orcid.org/0000-0002-6765-5621, Brown, E., Owens, A., Saguner, A.M., Meder, B. ORCID: https://orcid.org/0000-0003-0741-2633, Parikh, V. ORCID: https://orcid.org/0000-0002-5138-5559, Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172 and Steinmetz, L.M.
Nature Communications 14
(1): 4312.
18 July 2023
Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy.
Grosch, M. ORCID: https://orcid.org/0000-0001-9016-8920, Schraft, L. ORCID: https://orcid.org/0009-0005-4504-8926, Chan, A., Küchenhoff, L. ORCID: https://orcid.org/0000-0002-3715-4551, Rapti, K., Ferreira, A.M., Kornienko, J. ORCID: https://orcid.org/0000-0002-7876-230X, Li, S., Radke, M.H. ORCID: https://orcid.org/0000-0003-0112-9917, Krämer, C., Clauder-Münster, S., Perlas, E., Backs, J. ORCID: https://orcid.org/0000-0002-2322-2699, Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Dieterich, C. ORCID: https://orcid.org/0000-0001-9468-6311, van den Hoogenhof, M.M.G. ORCID: https://orcid.org/0000-0003-2768-3457, Grimm, D. ORCID: https://orcid.org/0000-0001-6227-5665 and Steinmetz, L.M. ORCID: https://orcid.org/0000-0002-3962-2865
Nature Communications 14
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22 June 2023
Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames.
Sandmann, C.L. ORCID: https://orcid.org/0000-0002-3847-0708, Schulz, J.F. ORCID: https://orcid.org/0000-0002-8157-2224, Ruiz-Orera, J. ORCID: https://orcid.org/0000-0002-8317-0034, Kirchner, M. ORCID: https://orcid.org/0000-0002-7049-534X, Ziehm, M. ORCID: https://orcid.org/0000-0001-7074-4054, Adami, E. ORCID: https://orcid.org/0000-0002-1813-6681, Marczenke, M., Christ, A. ORCID: https://orcid.org/0000-0002-2019-176X, Liebe, N., Greiner, J. ORCID: https://orcid.org/0009-0002-0811-3440, Schoenenberger, A., Mücke, M.B. ORCID: https://orcid.org/0000-0002-4957-3307, Liang, N. ORCID: https://orcid.org/0009-0008-8137-6873, Moritz, R.L., Sun, Z., Deutsch, E.W., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Mudge, J.M., Prensner, J.R., Willnow, T.E. ORCID: https://orcid.org/0000-0001-9515-7921, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, van Heesch, S. ORCID: https://orcid.org/0000-0001-9593-1980 and Hubner, N. ORCID: https://orcid.org/0000-0002-1218-6223
Molecular Cell 83
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16 March 2023
CAR links hypoxia signaling to improved survival after myocardial infarction.
Freiberg, F., Thakkar, M., Hamann, W., Lopez Carballo, J. ORCID: https://orcid.org/0000-0002-7735-7185, Jüttner, R. ORCID: https://orcid.org/0000-0003-3565-0698, Voss, F.K., Becher, P.M., Westermann, D., Tschöpe, C., Heuser, A. ORCID: https://orcid.org/0000-0002-3334-960X, Rocks, O. ORCID: https://orcid.org/0000-0001-6349-9193, Fischer, R. and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
Experimental and Molecular Medicine 55
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March 2023
Disease- and sex-specific differences in patients with heart valve disease: a proteome study.
Nordmeyer, S. ORCID: https://orcid.org/0000-0002-1111-2521, Kraus, M. ORCID: https://orcid.org/0000-0002-4472-0427, Ziehm, M. ORCID: https://orcid.org/0000-0001-7074-4054, Kirchner, M. ORCID: https://orcid.org/0000-0002-7049-534X, Schafstedde, M. ORCID: https://orcid.org/0000-0002-4860-8010, Kelm, M., Niquet, S., Stephen, M.M., Baczko, I. ORCID: https://orcid.org/0000-0002-9588-0797, Knosalla, C. ORCID: https://orcid.org/0000-0002-8127-5019, Schapranow, M.P. ORCID: https://orcid.org/0000-0001-6601-2942, Dittmar, G. ORCID: https://orcid.org/0000-0003-3647-8623, Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Falcke, M. ORCID: https://orcid.org/0000-0001-7137-1114, Regitz-Zagrosek, V., Kuehne, T. and Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X
Life Science Alliance 6
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March 2023
A single-cell RNA labeling strategy for measuring stress response upon tissue dissociation.
Neuschulz, A. ORCID: https://orcid.org/0000-0001-6163-3344, Bakina, O. ORCID: https://orcid.org/0000-0002-3486-9906, Badillo Lisakowski, V. ORCID: https://orcid.org/0000-0001-5906-2589, Olivares-Chauvet, P., Conrad, T. ORCID: https://orcid.org/0000-0001-5618-6295, Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Kettenmann, H. ORCID: https://orcid.org/0000-0001-8208-0291 and Junker, J.P. ORCID: https://orcid.org/0000-0002-2826-8290
Molecular Systems Biology 19
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10 February 2023
The IgCAM CAR regulates gap junction-mediated coupling on embryonic cardiomyocytes and affects their beating frequency.
Matthaeus, C. ORCID: https://orcid.org/0000-0003-3242-1195, Jüttner, R. ORCID: https://orcid.org/0000-0003-3565-0698, Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172 and Rathjen, F.G. ORCID: https://orcid.org/0000-0001-5351-613X
Life 13
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January 2023
Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation.
Ortiz-Zapater, E. ORCID: https://orcid.org/0000-0002-7437-4772, Bagley, D.C., Hernandez, V.L., Roberts, L.B. ORCID: https://orcid.org/0000-0003-1143-304X, Maguire, T.J.A. ORCID: https://orcid.org/0000-0003-1034-4926, Voss, F., Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Kirchner, M. ORCID: https://orcid.org/0000-0002-7049-534X, Peset-Martin, I., Woszczek, G. ORCID: https://orcid.org/0000-0003-0675-085X, Rosenblatt, J. ORCID: https://orcid.org/0000-0001-9460-5868, Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Santis, G. and Parsons, M. ORCID: https://orcid.org/0000-0002-2021-8379
Nature Communications 13
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27 October 2022
Proteome-wide quantitative RNA-interactome capture identifies phosphorylation sites with regulatory potential in RBM20.
Vieira e Vieira, C.H. ORCID: https://orcid.org/0000-0001-5443-4507, Dauksaite, V. ORCID: https://orcid.org/0000-0002-9399-4731, Sporbert, A. ORCID: https://orcid.org/0000-0002-3738-1295, Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172 and Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751
Molecular Cell 82
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2 June 2022
HDAC6 modulates myofibril stiffness and diastolic function of the heart.
Lin, Y.H., Major, J.L., Liebner, T. ORCID: https://orcid.org/0000-0003-0868-0859, Hourani, Z., Travers, J.G. ORCID: https://orcid.org/0000-0002-5660-2620, Wennersten, S.A. ORCID: https://orcid.org/0000-0002-9846-9530, Haefner, K.R., Cavasin, M.A., Wilson, C.E. ORCID: https://orcid.org/0000-0002-3513-344X, Jeong, M.Y., Han, Y., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Ferguson, S.K. ORCID: https://orcid.org/0000-0002-4446-6131, Ambardekar, A.V. ORCID: https://orcid.org/0000-0003-3503-4203, Lam, M.P. ORCID: https://orcid.org/0000-0001-9488-8319, Choudhary, C., Granzier, H.L. ORCID: https://orcid.org/0000-0002-9516-407X, Woulfe, K.C. ORCID: https://orcid.org/0000-0001-9885-7026 and McKinsey, T.A. ORCID: https://orcid.org/0000-0001-7778-4470
Journal of Clinical Investigation 132
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16 May 2022
RBM20 phosphorylation and its role in nucleocytoplasmic transport and cardiac pathogenesis.
Zhang, Y., Wang, C., Sun, M., Jin, Y., Braz, C.U., Khatib, H., Hacker, T.A., Liss, M. ORCID: https://orcid.org/0000-0002-0585-7850, Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Granzier, H. ORCID: https://orcid.org/0000-0002-9516-407X, Ge, Y. and Guo, W. ORCID: https://orcid.org/0000-0002-9158-8107
FASEB Journal 36
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May 2022
Regression from pathological hypertrophy in mice is sexually dimorphic and stimulus-specific.
Muehleman, D.L., Crocini, C. ORCID: https://orcid.org/0000-0001-8231-2726, Swearingen, A.R. ORCID: https://orcid.org/0000-0001-7072-5603, Ozeroff, C.D. and Leinwand, L.A. ORCID: https://orcid.org/0000-0003-1470-4810
American Journal of Physiology Heart and Circulatory Physiology 322
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May 2022
SLM2 is a novel cardiac splicing factor involved in heart failure due to dilated cardiomyopathy.
Boeckel, J.N. ORCID: https://orcid.org/0000-0002-7438-3089, Möbius-Winkler, M. ORCID: https://orcid.org/0000-0002-4400-3508, Müller, M. ORCID: https://orcid.org/0000-0002-8519-0661, Rebs, S. ORCID: https://orcid.org/0000-0002-9504-0261, Eger, N. ORCID: https://orcid.org/0000-0002-9488-4083, Schoppe, L. ORCID: https://orcid.org/0000-0003-0047-8760, Tappu, R. ORCID: https://orcid.org/0000-0003-0902-7114, Kokot, K.E. ORCID: https://orcid.org/0000-0002-8130-4289, Kneuer, J.M. ORCID: https://orcid.org/0000-0003-0273-3614, Gaul, S. ORCID: https://orcid.org/0000-0003-4780-1844, Bordalo, D.M., Lai, A. ORCID: https://orcid.org/0000-0003-0916-9227, Haas, J. ORCID: https://orcid.org/0000-0002-8040-8289, Ghanbari, M. ORCID: https://orcid.org/0000-0002-6015-2968, Drewe-Boss, P. ORCID: https://orcid.org/0000-0002-5459-9771, Liss, M. ORCID: https://orcid.org/0000-0002-0585-7850, Katus, H.A., Ohler, U. ORCID: https://orcid.org/0000-0002-0881-3116, Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Laufs, U. ORCID: https://orcid.org/0000-0003-2620-9323, Streckfuss-Bömeke, K. ORCID: https://orcid.org/0000-0001-5137-7228 and Meder, B. ORCID: https://orcid.org/0000-0003-0741-2633
Genomics Proteomics & Bioinformatics 20
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February 2022
Therapeutic inhibition of RBM20 improves diastolic function in a murine heart failure model and human engineered heart tissue.
Radke, M.H. ORCID: https://orcid.org/0000-0003-0112-9917, Badillo-Lisakowski, V. ORCID: https://orcid.org/0000-0001-5906-2589, Britto-Borges, T. ORCID: https://orcid.org/0000-0002-6218-4429, Kubli, D.A. ORCID: https://orcid.org/0000-0001-7970-4075, Jüttner, R. ORCID: https://orcid.org/0000-0003-3565-0698, Parakkat, P. ORCID: https://orcid.org/0000-0003-2691-791X, Lopez Carballo, J. ORCID: https://orcid.org/0000-0002-7735-7185, Hüttemeister, J., Liss, M. ORCID: https://orcid.org/0000-0002-0585-7850, Hansen, A., Dieterich, C. ORCID: https://orcid.org/0000-0001-9468-6311, Mullick, A.E. ORCID: https://orcid.org/0000-0003-4600-961X and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
Science Translational Medicine 13
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December 2021
Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes.
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Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
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Nature Communications 12
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Caveolin3 stabilizes McT1-mediated lactate/proton transport in cardiomyocytes.
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An immune-related lncRNA signature to predict survival in glioma patients.
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Wnt signalling pathway in bladder cancer.
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Identification of unique long non-coding RNAs as putative biomarkers for chromophobe renal cell carcinoma.
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Personalized Medicine 18
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January 2021
Assessment of nanoindentation in stiffness measurement of soft biomaterials: kidney, liver, spleen and uterus.
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Scientific Reports 10
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2 November 2020
Identification of glioma cancer stem cell characteristics based on weighted gene prognosis module co-expression network analysis of transcriptome data stemness indices.
Xia, P. ORCID: https://orcid.org/0000-0001-5086-1755, Li, Q., Wu, G. ORCID: https://orcid.org/0000-0002-5654-8046 and Huang, Y. ORCID: https://orcid.org/0000-0001-9600-1195
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October 2020
iPSC modeling of RBM20-deficient DCM identifies upregulation of RBM20 as a therapeutic strategy.
Briganti, F., Sun, H., Wei, W., Wu, J., Zhu, C., Liss, M. ORCID: https://orcid.org/0000-0002-0585-7850, Karakikes, I., Rego, S., Cipriano, A., Snyder, M., Meder, B., Xu, Z., Millat, G., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Mercola, M. and Steinmetz, L.M.
Cell Reports 32
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8 September 2020
Deconstructing sarcomeric structure-function relations in titin-BioID knock-in mice.
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Nature Communications 11
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Effects of hemodialysis on plasma oxylipins.
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Physiological Reports 8
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June 2020
Deleting titin's C-terminal PEVK exons increases passive stiffness, alters splicing, and induces cross-sectional and longitudinal hypertrophy in skeletal muscle.
van der Pijl, R.J., Hudson, B., Granzier-Nakajima, T., Li, F., Knottnerus, A.M., Smith, J., Chung, C.S., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Granzier, H.L. ORCID: https://orcid.org/0000-0002-9516-407X and Ottenheijm, C.A.C.
Frontiers in Physiology 11
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29 May 2020
NNT-AS1 enhances bladder cancer cell growth by targeting miR-1301-3p/PODXL axis and activating Wnt pathway.
Liu, Y. and Wu, G. ORCID: https://orcid.org/0000-0002-5654-8046
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February 2020
Real-time visualization of titin dynamics reveals extensive reversible photobleaching in human induced pluripotent stem cell-derived cardiomyocytes.
Cadar, A.G., Feaster, T.K., Bersell, K.R., Wang, L., Hong, T.T., Balsamo, J.A., Zhang, Z., Chun, Y.W., Nam, Y.J., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Knollmann, B.C., Roden, D.M., Lim, C.C. and Hong, C.C.
American Journal of Physiology Cell Physiology 318
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January 2020
Proteomic and transcriptomic changes in hibernating grizzly bears reveal metabolic and signaling pathways that protect against muscle atrophy.
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Scientific Reports 9
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27 December 2019
Microtubule cytoskeleton regulates connexin 43 localization and cardiac conduction in cardiomyopathy caused by mutation in A-type lamins gene.
Macquart, C., Jüttner, R. ORCID: https://orcid.org/0000-0003-3565-0698, Le Dour, C., Chatzifrangkeskou, M., Schmitt, A., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Bonne, G. and Muchir, A.
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15 December 2019
Resolving titin's lifecycle and the spatial organization of protein turnover in mouse cardiomyocytes.
Rudolph, F., Hüttemeister, J., da Silva Lopes, K., Jüttner, R. ORCID: https://orcid.org/0000-0003-3565-0698, Yu, L., Bergmann, N., Friedrich, D. ORCID: https://orcid.org/0000-0003-2144-9280, Preibisch, S. ORCID: https://orcid.org/0000-0002-0276-494X, Wagner, E., Lehnart, S.E. ORCID: https://orcid.org/0000-0002-8115-3513, Gregorio, C.C. and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
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10 December 2019
Maximal exercise and erythrocyte epoxy fatty acids: a lipidomics study.
Gollasch, B. ORCID: https://orcid.org/0000-0001-5267-518X, Wu, G. ORCID: https://orcid.org/0000-0002-5654-8046, Dogan, I., Rothe, M., Gollasch, M. ORCID: https://orcid.org/0000-0003-2797-1934 and Luft, F.C. ORCID: https://orcid.org/0000-0002-8635-1199
Physiological Reports 7
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November 2019
Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction.
Friebel, J., Weithauser, A., Witkowski, M., Rauch, B.H., Savvatis, K., Dörner, A., Tabaraie, T., Kasner, M., Moos, V., Bösel, D., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Radke, M.H. ORCID: https://orcid.org/0000-0003-0112-9917, Wegner, M., Bobbert, P., Lassner, D., Tschöpe, C., Schutheiss, H.P., Felix, S.B., Landmesser, U. and Rauch, U.
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21 October 2019
Clinical relevance of semaphorin-3F in patients with prostate cancer.
Wu, G. ORCID: https://orcid.org/0000-0002-5654-8046
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29 September 2019
The cell adhesion protein CAR is a negative regulator of synaptic transmission.
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Scientific Reports 9
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1 May 2019
Deleting full length titin versus the titin M-band region leads to differential mechanosignaling and cardiac phenotypes.
Radke, M.H. ORCID: https://orcid.org/0000-0003-0112-9917, Polack, C., Methawasin, M., Fink, C., Granzier, H.L. ORCID: https://orcid.org/0000-0002-9516-407X and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
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Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance.
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January 2019
Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.
Liss, M. ORCID: https://orcid.org/0000-0002-0585-7850, Radke, M.H. ORCID: https://orcid.org/0000-0003-0112-9917, Eckhard, J., Neuenschwander, M. ORCID: https://orcid.org/0000-0002-3114-7975, Dauksaite, V. ORCID: https://orcid.org/0000-0002-9399-4731, von Kries, J.P. ORCID: https://orcid.org/0000-0003-4716-4988 and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
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Molecular basis of titin exon exclusion by RBM20 and the novel titin splice regulator PTB4.
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1 June 2018
Expanding the map of protein-RNA interaction sites via cell fusion followed by PAR-CLIP.
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RNA Biology 15
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4 March 2018
Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy.
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7 December 2017
Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.
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Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy.
Hinze, F., Dieterich, C. ORCID: https://orcid.org/0000-0001-9468-6311, Radke, M.H. ORCID: https://orcid.org/0000-0003-0112-9917, Granzier, H. ORCID: https://orcid.org/0000-0002-9516-407X and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
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Axial tubule junctions control rapid calcium signaling in atria.
Brandenburg, S., Kohl, T., Williams, G.S.B., Gusev, K., Wagner, E., Rog-Zielinska, E.A., Hebisch, E., Dura, M., Didié, M., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Nikolaev, V.O., Hasenfuss, G., Kohl, P., Ward, C.W., Lederer, W.J. and Lehnart, S.E. ORCID: https://orcid.org/0000-0002-8115-3513
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3 October 2016
Podocyte-specific deletion of murine CXADR does not impair podocyte development, function or stress response.
Schell, C., Kretz, O., Bregenzer, A., Rogg, M., Helmstädter, M., Lisewski, U., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Tharaux, P.L., Huber, T.B. and Grahammer, F.
PLoS ONE 10
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15 June 2015
The Src Homology and Collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/Z-disk network during heart development.
Mlih, M., Host, L., Martin, S., Niederhoffer, N., Monassier, L., Terrand, J., Messaddeq, N., Radke, M. ORCID: https://orcid.org/0000-0003-0112-9917, Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Bruban, V., Kober, F., Bernard, M., Canet-Soulas, E., Abt-Jijon, F., Boucher, P. and Matz, R.L.
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Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease.
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Science Translational Medicine 7
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14 January 2015
Moderate inappropriately high aldosterone/NaCl constellation in mice: cardiovascular effects and the role of cardiovascular epidermal growth factor receptor.
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Scientific Reports 4
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Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics.
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RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing.
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1 August 2014
Interspecies differences in virus uptake versus cardiac function of the coxsackievirus and adenovirus receptor.
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1 July 2014
Coxsackie and adenovirus receptor (CAR) is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia.
Marsman, R.F.J., Bezzina, C.R., Freiberg, F., Verkerk, A.O., Adriaens, M.E., Podliesna, S., Chen, C., Purfürst, B. ORCID: https://orcid.org/0000-0002-9887-7577, Spallek, B., Koopmann, T.T., Baczko, I., Dos Remedios, C.G., George, A.L., Bishopric, N.H., Lodder, E.M., de Bakker, J.M.T., Fischer, R. ORCID: https://orcid.org/0000-0002-4828-2882, Coronel, R., Wilde, A.A.M., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172 and Remme, C.A.
Journal of the American College of Cardiology 63
(6): 549-559.
18 February 2014
Recessive TTN truncating mutations define novel forms of core myopathy with heart disease.
Chauveau, C., Bonnemann, C.G., Julien, C., Kho, A.L., Marks, H., Talim, B., Maury, P., Arne-Bes, M.C., Uro-Coste, E., Alexandrovich, A., Vihola, A., Schafer, S., Kaufmann, B., Medne, L., Hübner, N. ORCID: https://orcid.org/0000-0002-1218-6223, Foley, A.R., Santi, M., Udd, B., Topaloglu, H., Moore, S.A., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Samuels, M.E., Gautel, M. and Ferreiro, A.
Human Molecular Genetics 23
(4): 980-991.
15 February 2014
Calcium sensitivity and myofilament lattice structure in titin N2B KO mice.
Lee, E.J., Nedrud, J., Schemmel, P., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Irving, T.C. and Granzier, H.L. ORCID: https://orcid.org/0000-0002-9516-407X
Archives of Biochemistry and Biophysics 535
(1): 76-83.
1 July 2013
Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy.
Schreier, B., Rabe, S., Schneider, B., Bretschneider, M., Rupp, S., Ruhs, S., Neumann, J., Rueckschloss, U., Sibilia, M., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Grossmann, C. and Gekle, M.
Hypertension 61
(2): 333-340.
February 2013
RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing.
Guo, W., Schafer, S., Greaser, M.L., Radke, M.H. ORCID: https://orcid.org/0000-0003-0112-9917, Liss, M. ORCID: https://orcid.org/0000-0002-0585-7850, Govindarajan, T., Maatz, H. ORCID: https://orcid.org/0000-0002-9232-6272, Schulz, H. ORCID: https://orcid.org/0000-0002-0226-964X, Lincoln, S.E., Parrish, A.M., Dauksaite, V. ORCID: https://orcid.org/0000-0002-9399-4731, Vakeel, P., Klaassen, S. ORCID: https://orcid.org/0000-0001-5925-9912, Gerull, B. ORCID: https://orcid.org/0000-0002-1363-8826, Thierfelder, L., Regitz-Zagrosek, V., Hacker, T.A., Saupe, K.W., Dec, G.W., Ellinor, P.T., MacRae, C.A., Spallek, B., Fischer, R. ORCID: https://orcid.org/0000-0002-4828-2882, Perrot, A. ORCID: https://orcid.org/0000-0002-8800-342X, Ozcelik, C., Saar, K. ORCID: https://orcid.org/0000-0002-4483-1557, Hubner, N. ORCID: https://orcid.org/0000-0002-1218-6223 and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
Nature Medicine 18
(5): 766-773.
May 2012
Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycle.
Nedrud, J., Labeit, S., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172 and Granzier, H. ORCID: https://orcid.org/0000-0002-9516-407X
Biophysical Journal 101
(6): 1385-1392.
21 September 2011
Titin based viscosity in ventricular physiology: An integrative investigation of PEVK-actin interactions.
Chung, C.S., Methawasin, M., Nelson, O.L., Radke, M.H. ORCID: https://orcid.org/0000-0003-0112-9917, Hidalgo, C.G., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172 and Granzier, H.L. ORCID: https://orcid.org/0000-0002-9516-407X
Journal of Molecular and Cellular Cardiology 51
(3): 428-434.
September 2011
Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1.
Schreier, B., Doehler, M., Rabe, S., Schneider, B., Schwerdt, G., Ruhs, S., Sibilia, M., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Gekle, M. and Grossmann, C.
Arteriosclerosis Thrombosis and Vascular Biology 31
(7): 1643-1652.
July 2011
Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres.
da Silva Lopes, K., Pietas, A., Radke, M.H. ORCID: https://orcid.org/0000-0003-0112-9917 and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
Journal of Cell Biology 193
(4): 785-798.
16 May 2011
Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region deficient mice.
Lee, E.J., Peng, J., Radke, M. ORCID: https://orcid.org/0000-0003-0112-9917, Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172 and Granzier, H.L. ORCID: https://orcid.org/0000-0002-9516-407X
Journal of Molecular and Cellular Cardiology 49
(3): 449-458.
September 2010
Excision of titin's cardiac PEVK spring element abolishes PKCalpha-induced increases in myocardial stiffness.
Hudson, B.D., Hidalgo, C.G., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172 and Granzier, H.L. ORCID: https://orcid.org/0000-0002-9516-407X
Journal of Molecular and Cellular Cardiology 48
(5): 972-978.
May 2010
Altered contractility of skeletal muscle in mice deficient in titin's M-band region.
Ottenheijm, C.A., Hidalgo, C., Rost, K., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172 and Granzier, H. ORCID: https://orcid.org/0000-0002-9516-407X
Journal of Molecular Biology 393
(1): 10-26.
16 October 2009
Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction.
Granzier, H.L. ORCID: https://orcid.org/0000-0002-9516-407X, Radke, M.H. ORCID: https://orcid.org/0000-0003-0112-9917, Peng, J., Westermann, D., Nelson, O.L., Rost, K., King, N.M., Yu, Q., Tschoepe, C., McNabb, M., Larson, D.F., Labeit, S. and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
Circulation Research 105
(6): 557-564.
11 September 2009
Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure.
Westermann, D., Riad, A., Richter, U., Jaeger, S., Savvatis, K., Schuchardt, M., Bergmann, N., Toelle, M., Nagorsen, D., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Schultheiss, H.P. and Tschoepe, C.
Basic Research in Cardiology 104
(5): 499-509.
September 2009
Cardiac deletion of the coxsackievirus-adenovirus receptor abolishes coxsackievirus b3 infection and prevents myocarditis in vivo.
Shi, Y., Chen, C., Lisewski, U., Wrackmeyer, U., Radke, M. ORCID: https://orcid.org/0000-0003-0112-9917, Westermann, D., Sauter, M., Tschoepe, C., Poller, W., Klingel, K. and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
Journal of the American College of Cardiology 53
(14): 1219-1226.
7 April 2009
The tight junction protein CAR regulates cardiac conduction and cell-cell communication.
Lisewski, U., Shi, Y., Wrackmeyer, U., Fischer, R. ORCID: https://orcid.org/0000-0002-4828-2882, Chen, C., Schirdewan, A., Juettner, R. ORCID: https://orcid.org/0000-0003-3565-0698, Rathjen, F.G. ORCID: https://orcid.org/0000-0001-5351-613X, Poller, W., Radke, M.H. ORCID: https://orcid.org/0000-0003-0112-9917 and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
Journal of Experimental Medicine 205
(10): 2369-2379.
29 September 2008
Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis.
Lukowski, R., Weinmeister, P., Bernhard, D., Feil, S., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Herz, J., Massberg, S., Zernecke, A., Weber, C., Hofmann, F. and Feil, R.
Arteriosclerosis Thrombosis and Vascular Biology 28
(7): 1244-1250.
July 2008
A proteome map of murine heart and skeletal muscle.
Raddatz, K., Albrecht, D., Hochgraefe, F., Hecker, M. and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
Proteomics 8
(9): 1885-1897.
May 2008
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.
Jansen, P., Giehl, K., Nyengaard, J.R., Teng, K., Lioubinski, O., Sjoegaard, S.S., Breiderhoff, T. ORCID: https://orcid.org/0000-0002-1676-7498, Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Lin, F., Eilers, A., Petersen, C.M., Lewin, G.R. ORCID: https://orcid.org/0000-0002-2890-6352, Hempstead, B.L., Willnow, T.E. ORCID: https://orcid.org/0000-0001-9515-7921 and Nykjaer, A.
Nature Neuroscience 10
(11): 1449-1457.
November 2007
Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy.
Radke, M.H. ORCID: https://orcid.org/0000-0003-0112-9917, Peng, J., Wu, Y., McNabb, M., Nelson, O.L., Granzier, H. ORCID: https://orcid.org/0000-0002-9516-407X and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
Proceedings of the National Academy of Sciences of the United States of America 104
(9): 3444-3449.
27 February 2007
Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region.
Peng, J., Raddatz, K., Molkentin, J.D., Wu, Y., Labeit, S., Granzier, H. ORCID: https://orcid.org/0000-0002-9516-407X and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
Circulation 115
(6): 743-751.
13 February 2007
M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere.
Weinert, S. ORCID: https://orcid.org/0000-0003-3036-1440, Bergmann, N., Luo, X., Erdmann, B. ORCID: https://orcid.org/0000-0002-9887-7577 and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
Journal of Cell Biology 173
(4): 559-570.
22 May 2006
Muscle atrophy in titin M-line deficient mice.
Peng, J., Raddatz, K., Labeit, S., Granzier, H. ORCID: https://orcid.org/0000-0002-9516-407X and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
Journal of Muscle Research and Cell Motility 26
(6-8): 381-388.
1 December 2005
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Andersen, O.M. ORCID: https://orcid.org/0000-0003-4226-3354, Reiche, J., Schmidt, V. ORCID: https://orcid.org/0000-0002-5851-1087, Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Spoelgen, R., Behlke, J., von Arnim, C.A.F., Breiderhoff, T. ORCID: https://orcid.org/0000-0002-1676-7498, Jansen, P., Wu, X., Bales, K.R., Cappai, R., Masters, C.L., Gliemann, J., Mufson, E.J., Hyman, B.T., Paul, S.M., Nykjaer, A. and Willnow, T.E. ORCID: https://orcid.org/0000-0001-9515-7921
Proceedings of the National Academy of Sciences of the United States of America 102
(38): 13461-13466.
7 September 2005
Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling.
Witt, C.C., Ono, Y., Puschmann, E., McNabb, M., Wu, Y., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Witt, S.H., Haak, M., Labeit, D., Gregorio, C.C., Sorimachi, H., Granzier, H. ORCID: https://orcid.org/0000-0002-9516-407X and Labeit, S.
Journal of Molecular Biology 336
: 145-154.
1 January 2004
LRP: role in vascular wall integrity and protection from atherosclerosis.
Boucher, P., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Li, W.P., Anderson, R.G. and Herz, J.
Science 300
: 329-332.
11 April 2003
Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure.
Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Hammer, R.E., Hübner, N. ORCID: https://orcid.org/0000-0002-1218-6223, Monti, J., Witt, C.C., McNabb, M., Richardson, J.A., Granzier, H. ORCID: https://orcid.org/0000-0002-9516-407X, Labeit, S. and Herz, J.
Journal of Biological Chemistry 278
(8): 6059-6065.
21 February 2003
Adaptations in titin's spring elements in normal and cardiomyopathic hearts.
Granzier, H. ORCID: https://orcid.org/0000-0002-9516-407X, Labeit, D., Wu, Y., Witt, C., Watanabe, K., Lahmers, S., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172 and Labeit, S.
Advances in Experimental Medicine and Biology 538
(538): 517-530; discussion 530-531.
2003
Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure.
Holtwick, R., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Skryabin, B., Steinmetz, M., Potthast, R., Zetsche, B., Hammer, R.E., Herz, J. and Kuhn, M.
Proceedings of the National Academy of Sciences of the United States of America 99
: 7142-7147.
14 May 2002
Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low Density lipoprotein receptor-related protein in caveolae.
Boucher, P., Liu, P., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Hiesberger, T., Anderson, R.G. and Herz, J.
Journal of Biological Chemistry 277
: 15507-15513.
3 May 2002
Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice.
Vasandani, C., Kafrouni, A.I., Caronna, A., Bashmakov, Y., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Horton, J.D. and Spady, D.K.
Journal of Lipid Research 43
: 772-784.
1 May 2002
The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system.
Bang, M.L., Centner, T., Fornoff, F., Geach, A.J., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, McNabb, M., Witt, C.C., Labeit, D., Gregorio, C.C., Granzier, H. ORCID: https://orcid.org/0000-0002-9516-407X and Labeit, S.
Circulation Research 89
: 1065-1072.
23 November 2001
Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.
Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Trommsdorff, M., Nevitt, M.F., Shelton, J., Richardson, J.A., Stockinger, W., Nimpf, J. and Herz, J.
Journal of Biological Chemistry 275
(33): 25616-25624.
18 August 2000
The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2.
Stockinger, W., Brandes, C., Fasching, D., Hermann, M., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Herz, J., Schneider, W.J. and Nimpf, J.
Journal of Biological Chemistry 275
(33): 25625-25632.
18 August 2000
Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor.
Schmitz, C., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Hinderlich, S., Leheste, J.R., Gross, V., Vorum, H., Christensen, E.I., Luft, F.C. ORCID: https://orcid.org/0000-0002-8635-1199, Takahashi, S. and Willnow, T.E. ORCID: https://orcid.org/0000-0001-9515-7921
Journal of Biological Chemistry 275
(20): 15357-15362.
19 May 2000
Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.
Trommsdorff, M., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Hiesberger, T., Shelton, J., Stockinger, W., Nimpf, J., Hammer, R.E., Richardson, J.A. and Herz, J.
Cell 97
(6): 689-701.
11 June 1999
Inducible inactivation of hepatic LRP gene by Cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants.
Rohlmann, A., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Hammer, R.E. and Herz, J.
Journal of Clinical Investigation 101
(3): 689-695.
1 February 1998
Sustained somatic gene inactivation by viral transfer of Cre recombinase.
Rohlmann, A., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Willnow, T.E. ORCID: https://orcid.org/0000-0001-9515-7921, Hammer, R.E. and Herz, J.
Nature Biotechnology 14
(11): 1562-1565.
1 November 1996
Moeglichkeiten und Grenzen der Gentherapie.
Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172 and Strauss, M.
Monatsschrift fuer Kinderheilkunde 142
: 930-940.
1 January 1994
Book Section
Cardiac signaling: cellular, molecular and clinical aspects.
Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172 and Raddatz, K.
In:
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 1.
Springer, Berlin [u.a.], 208-214.
ISBN 3-540-44244-8
2006
Gene therapy for familial hypercholesterolemia.
Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172 and Schuster, H.
In:
Concepts in gene therapy.
de Gruyter, Berlin; New York, 359-386.
1 January 1997
Thesis
Titin M-line deficiency causes impaired myofibril maturation and cardiac dysfunction.
Weinert, S. ORCID: https://orcid.org/0000-0003-3036-1440
UNSPECIFIED thesis, UNSPECIFIED.
22 September 2006
Patent
Induzierbare ortsspezifische Mutagenese durch bedingte Genrettung [Inducible site-directed mutagenesis through conditional gene rescue].
Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172 and Radke, M. ORCID: https://orcid.org/0000-0003-0112-9917
EP1466974 ; WO0470042.
13 October 2004
LDL receptor signaling pathways.
Herz, J. and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
US6,428,967.
6 August 2002
Review
Cardiac splicing as a diagnostic and therapeutic target.
Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Badillo Lisakowski, V. ORCID: https://orcid.org/0000-0001-5906-2589, Parikh, V.N., Ashley, E. ORCID: https://orcid.org/0000-0001-9418-9577, Furtado, M., Carmo-Fonseca, M. ORCID: https://orcid.org/0000-0002-3402-7143, Schudy, S., Meder, B., Grosch, M., Steinmetz, L., Crocini, C. ORCID: https://orcid.org/0000-0001-8231-2726 and Leinwand, L. ORCID: https://orcid.org/0000-0003-1470-4810
Nature Reviews Cardiology 20
(8): 517-530.
August 2023
Cardiac sarcomere mechanics in health and disease.
Crocini, C. ORCID: https://orcid.org/0000-0001-8231-2726 and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
Biophysical Reviews 13
(5): 637-652.
October 2021
RBM20-related cardiomyopathy: current understanding and future options.
Koelemen, J. ORCID: https://orcid.org/0000-0003-4760-7582, Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Steinmetz, L.M. and Meder, B.
Journal of Clinical Medicine 10
(18): 4101.
2 September 2021
A systematic review and meta- analysis of green-light laser vaporization for superficial bladder cancer.
Xu, Z., Gan, G., Chen, G. and Wu, G. ORCID: https://orcid.org/0000-0002-5654-8046
Urology Journal 17
(6): 578-586.
January 2021
CAR-diology - a virus receptor in the healthy and diseased heart.
Fischer, R. ORCID: https://orcid.org/0000-0002-4828-2882, Poller, W., Schultheiss, H.P. and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
Journal of Molecular Medicine 87
(9): 879-884.
September 2009
Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle.
Granzier, H. ORCID: https://orcid.org/0000-0002-9516-407X, Radke, M. ORCID: https://orcid.org/0000-0003-0112-9917, Royal, J., Wu, Y., Irving, T.C., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172 and Labeit, S.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 293
(2): R557-R567.
1 August 2007
LRP and PDGF signaling: a pathway to atherosclerosis.
Boucher, P. and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
Trends in Cardiovascular Medicine 14
(2): 55-60.
February 2004
Cellular signalling by lipoprotein receptors.
Herz, J., Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172 and Willnow, T.E. ORCID: https://orcid.org/0000-0001-9515-7921
Current Opinion in Lipidology 11
(2): 161-166.
1 April 2000
Editorial
RNA-binding proteins as therapeutic targets in cardiac fibrosis and heart failure.
Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172
European Heart Journal 47
(1): 128-130.
1 January 2026
SERCA2a microdomain cAMP changes in heart failure with preserved ejection fraction.
Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172 and Lehnart, S.E. ORCID: https://orcid.org/0000-0002-8115-3513
Cardiovascular Research 120
(3): 220-222.
February 2024
Preprint
Multi-omics insight into cardiac myofibril remodeling in post-prandial burmese pythons.
Martin, Thomas G. ORCID: https://orcid.org/0000-0002-1300-4890, Suarez-Artiles, Lorena ORCID: https://orcid.org/0000-0001-7991-5446, Woulfe, Kathleen C., Melhedegaard, Elise G., Tan, Yuxiao, Hunt, Dakota R., Kirkpatrick, Bruce E., Nguyen, Lia, Lee, Joseph, Laskey, Isabella, Anseth, Kristi S., Ochala, Julien, Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172, Mertins, Philipp ORCID: https://orcid.org/0000-0002-2245-528X and Leinwand, Leslie A. ORCID: https://orcid.org/0000-0003-1470-4810
bioRxiv
: 2026.02.02.703272.
4 February 2026
Plasma proteomics in acute heart failure: survival-associated protein signatures and 90-day trajectories.
Chitroceanu, Alexandra M., Fahjen, Pauline ORCID: https://orcid.org/0000-0002-5015-0643, Schulze, Daniel, Zach, Veronika, Alasfar, Lina, Ziehm, Matthias ORCID: https://orcid.org/0000-0001-7074-4054, Kirchner, Marieluise ORCID: https://orcid.org/0000-0002-7049-534X, Niquet, Sylvia, Dahmen, Jan-Niklas, Plappert, Carlos, Kretzler, Lucie, Kind, Andreas, Zurkan, Daniela, Pinto, Rafaela Maria, Reynolds, Edwardo, Trippel, Tobias D., Forslund, Sofia ORCID: https://orcid.org/0000-0003-4285-6993, Grittner, Ulrike, Mai, Knut, Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172, Schiattarella, Gabriele G. ORCID: https://orcid.org/0000-0002-7582-7171, Kintscher, Ulrich, Ahmadi, Michael, Boldt, Leif-Hendrik, Buchmann, Nikolaus, Eckardt, Kai-Uwe, Endres, Matthias, Gerhardt, Holger ORCID: https://orcid.org/0000-0002-3030-0384, Hübner, Norbert ORCID: https://orcid.org/0000-0002-1218-6223, Kollmus-Heege, Jil, Landmesser, Ulf, Müller, Dominik N. ORCID: https://orcid.org/0000-0003-3650-5644, Nolte, Christian H., Piper, Sophie K., Rattan, Simrit, Rohrpasser-Napierkowski, Ira, Schönrath, Katharina, Schulz-Menger, Jeanette ORCID: https://orcid.org/0000-0003-3100-1092, Schweizerhof, Oliver, Pischon, Tobias ORCID: https://orcid.org/0000-0003-1568-767X, Pieske, Burkert ORCID: https://orcid.org/0000-0002-6466-5306, Weber, Joachim, Mertins, Philipp ORCID: https://orcid.org/0000-0002-2245-528X and Edelmann, Frank
medRxiv
: 2025.12.01.25341310.
3 December 2025
Butyrate rescues cardiac metabolic dysfunction in hypertensive heart failure with preserved ejection fraction.
Kedziora, Sarah M. ORCID: https://orcid.org/0000-0003-0124-2557, Geisberger, Sabrina Y. ORCID: https://orcid.org/0000-0001-6477-1312, Popp, Oliver ORCID: https://orcid.org/0000-0001-6240-4666, Frolova, Alina ORCID: https://orcid.org/0000-0001-5469-7366, Uhrbach, Alisa, Kräker, Kristin ORCID: https://orcid.org/0000-0002-4032-5382, Tagiyeva, Nurana ORCID: https://orcid.org/0009-0006-7918-1220, Kelm, Marcus, Berndt, Nikolaus, Zhang, Yiming D. ORCID: https://orcid.org/0009-0003-9465-2033, Mastrobuoni, Guido ORCID: https://orcid.org/0000-0003-4509-1295, Escrihuela-Branz, Raquel, Bartolomaeus, Theda U.P. ORCID: https://orcid.org/0000-0002-5156-7184, Pixner, Lorenz, Fahjen, Pauline ORCID: https://orcid.org/0000-0002-5015-0643, Kaufhold, Gelsomina N. ORCID: https://orcid.org/0009-0009-0868-3284, Parakkat, Pragati ORCID: https://orcid.org/0000-0003-2691-791X, Chitroceanu, Alexandra Maria, Tschöpe, Carsten, Edelmann, Frank, Schiattarella, Gabriele G. ORCID: https://orcid.org/0000-0002-7582-7171, Forslund, Sofia K. ORCID: https://orcid.org/0000-0003-4285-6993, Wilck, Nicola ORCID: https://orcid.org/0000-0003-3189-5364, Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172, Mertins, Philipp ORCID: https://orcid.org/0000-0002-2245-528X, Dechend, Ralf ORCID: https://orcid.org/0000-0001-6636-3080, Sawamiphak, Suphansa ORCID: https://orcid.org/0000-0003-2298-3565, Müller, Dominik N. ORCID: https://orcid.org/0000-0003-3650-5644, Kempa, Stefan ORCID: https://orcid.org/0000-0002-0696-9299 and Haase, Nadine ORCID: https://orcid.org/0000-0003-0727-1738
bioRxiv
: 2025.11.28.690152.
30 November 2025
Visualizing sarcomere and cellular dynamics in skeletal muscle to improve cell therapies.
Hüttemeister, J., Rudolph, F., Radke, M.H. ORCID: https://orcid.org/0000-0003-0112-9917, Fink, C., Friedrich, D. ORCID: https://orcid.org/0000-0003-2144-9280, Preibisch, S. ORCID: https://orcid.org/0000-0002-0276-494X, Falcke, M. ORCID: https://orcid.org/0000-0001-7137-1114, Wagner, E., Lehnart, S.E. and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
bioRxiv
: 2024.02.01.578471.
7 February 2024
Dataset
Cryo-EM tomograms.
Ignatyeva, Nadezda, Cheruiyot, Cleophas, Saleem, Hafiza Nosheen, Wali, Ruheen, Plota, Daria, Zhang, Wenjing, Schön, Sophie, Brandenburg, Soeren, Yang, Zhengyi, Steyer, Anna, Urlaub, Henning, Rasmussen, Torsten, Mogensen, Jens, Pronto, Julius Ryan D., Döring, Yannic, Radke, Michael H. ORCID: https://orcid.org/0000-0003-0112-9917, Shcherbata, Halyna, Lehnart, Stephan E. ORCID: https://orcid.org/0000-0002-8115-3513, Janshoff, Andreas, Sossalla, Samuel, Ruhwedel, Torben, Moebius, Wiebke, Toischer, Karl, Brügger, Britta, Haucke, Volker ORCID: https://orcid.org/0000-0003-3119-6993, Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172, Voigt, Niels and Ebert, Antje
[Dataset]
16 April 2026
Intact cardiomyocyte stress-sarcomere length relation.
Methawasin, Mei ORCID: https://orcid.org/0000-0002-2509-1936, Meinke, Stefan ORCID: https://orcid.org/0000-0001-5083-3383, Radke, Michael ORCID: https://orcid.org/0000-0003-0112-9917, Farman, Gerrie ORCID: https://orcid.org/0000-0001-8095-8179, Hourani, Zaynab ORCID: https://orcid.org/0009-0004-9726-050X, Smith, John Edward III ORCID: https://orcid.org/0000-0002-0888-1274, Guo, Wei ORCID: https://orcid.org/0000-0002-9158-8107, Granzier, Henk ORCID: https://orcid.org/0000-0002-9516-407X and Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172
[Dataset]
19 September 2025
Analyzed echocardiographic parameters.
Methawasin, Mei ORCID: https://orcid.org/0000-0002-2509-1936, Meinke, Stefan ORCID: https://orcid.org/0000-0001-5083-3383, Radke, Michael ORCID: https://orcid.org/0000-0003-0112-9917, Farman, Gerrie ORCID: https://orcid.org/0000-0001-8095-8179, Hourani, Zaynab ORCID: https://orcid.org/0009-0004-9726-050X, Smith III, John E., Guo, Wei ORCID: https://orcid.org/0000-0002-9158-8107, Granzier, Henk ORCID: https://orcid.org/0000-0002-9516-407X and Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172
[Dataset]
18 September 2025
Ca2+ release-reuptake kinetics.
Methawasin, Mei, Meinke, Stefan ORCID: https://orcid.org/0000-0001-5083-3383, Radke, Michael ORCID: https://orcid.org/0000-0003-0112-9917, Farman, Gerrie, Hourani, Zaynab, Smith, John Edward III, Guo, Wei, Granzier, Henk ORCID: https://orcid.org/0000-0002-9516-407X and Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172
[Dataset]
18 September 2025
Electrocardiogram.
Methawasin, Mei ORCID: https://orcid.org/0000-0002-2509-1936, Meinke, Stefan ORCID: https://orcid.org/0000-0001-5083-3383, Radke, Michael ORCID: https://orcid.org/0000-0003-0112-9917, Farman, Gerrie ORCID: https://orcid.org/0000-0001-8095-8179, Hourani, Zaynab ORCID: https://orcid.org/0009-0004-9726-050X, Smith, John Edward III, Granzier, Henk ORCID: https://orcid.org/0000-0002-9516-407X and Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172
[Dataset]
18 September 2025
Permeabilized cardiomyocytes passive force measurement.
Methawasin, Mei ORCID: https://orcid.org/0000-0002-2509-1936, Meinke, Stefan ORCID: https://orcid.org/0000-0001-5083-3383, Radke, Michael ORCID: https://orcid.org/0000-0003-0112-9917, Farman, Gerrie ORCID: https://orcid.org/0000-0001-8095-8179, Hourani, Zaynab ORCID: https://orcid.org/0009-0004-9726-050X, Smith, John Edward III ORCID: https://orcid.org/0000-0002-0888-1274, Guo, Wei ORCID: https://orcid.org/0000-0002-9158-8107, Granzier, Henk ORCID: https://orcid.org/0000-0002-9516-407X and Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172
[Dataset]
18 September 2025
Picrosirius Red staining of LV myocardium.
Methawasin, Mei ORCID: https://orcid.org/0000-0002-2509-1936, Meinke, Stefan ORCID: https://orcid.org/0000-0001-5083-3383, Radke, Michael ORCID: https://orcid.org/0000-0003-0112-9917, Farman, Gerrie ORCID: https://orcid.org/0000-0001-8095-8179, Hourani, Zaynab ORCID: https://orcid.org/0009-0004-9726-050X, Smith, John Edward III, Guo, Wei ORCID: https://orcid.org/0000-0002-9158-8107, Granzier, Henk ORCID: https://orcid.org/0000-0002-9516-407X and Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172
[Dataset]
18 September 2025
Pressure-volume analysis.
Methawasin, Mei ORCID: https://orcid.org/0000-0002-2509-1936, Meinke, Stefan ORCID: https://orcid.org/0000-0001-5083-3383, Radke, Michael ORCID: https://orcid.org/0000-0003-0112-9917, Farman, Gerrie ORCID: https://orcid.org/0000-0001-8095-8179, Hourani, Zaynab ORCID: https://orcid.org/0009-0004-9726-050X, Smith, John Edward III ORCID: https://orcid.org/0000-0002-0888-1274, Guo, Wei ORCID: https://orcid.org/0000-0002-9158-8107, Granzier, Henk ORCID: https://orcid.org/0000-0002-9516-407X and Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172
[Dataset]
18 September 2025
Titin isoform analysis and RBM20 western blot.
Methawasin, Mei ORCID: https://orcid.org/0000-0002-2509-1936, Meinke, Stefan ORCID: https://orcid.org/0000-0001-5083-3383, Radke, Michael ORCID: https://orcid.org/0000-0003-0112-9917, Farman, Gerrie ORCID: https://orcid.org/0000-0001-8095-8179, Hourani, Zaynab ORCID: https://orcid.org/0009-0004-9726-050X, Smith, John Edward III, Guo, Wei ORCID: https://orcid.org/0000-0002-9158-8107, Granzier, H. ORCID: https://orcid.org/0000-0002-9516-407X and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
[Dataset]
18 September 2025
Analysis of calcium spike trains in HEK293 cells.
Azzoni, Caterina ORCID: https://orcid.org/0009-0009-4926-3534, Sporbert, Anje ORCID: https://orcid.org/0000-0002-3738-1295, Jüttner, Rene ORCID: https://orcid.org/0000-0003-3565-0698, Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172, Roderick, Llewelyn ORCID: https://orcid.org/0000-0001-7065-3523 and Falcke, Martin ORCID: https://orcid.org/0000-0001-7137-1114
[Dataset]
September 2025
Fluorescence intensity data from HEK293 Ca(2+) spike trains.
Azzoni, Caterina ORCID: https://orcid.org/0009-0009-4926-3534, Sporbert, Anje ORCID: https://orcid.org/0000-0002-3738-1295, Jüttner, Rene ORCID: https://orcid.org/0000-0003-3565-0698, Gotthardt, Michael ORCID: https://orcid.org/0000-0003-1788-3172, Roderick, Llewelyn ORCID: https://orcid.org/0000-0001-7065-3523 and Falcke, Martin ORCID: https://orcid.org/0000-0001-7137-1114
[Dataset]
September 2025
This list was generated on Mon Jul 13 04:43:54 2026 UTC.
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