Browse by Research Team

2024

Titin's cardiac-specific N2B element is critical to mechanotransduction during volume overload of the heart.
Strom, J., Bull, M., Gohlke, J., Saripalli, C., Methawasin, M., Gotthardt, M. and Granzier, H.
Journal of Molecular and Cellular Cardiology 191 : 40-49. June 2024

Loss of cardiac splicing regulator RBM20 is associated with early-onset atrial fibrillation.
Vad, O.B., Angeli, E., Liss, M., Ahlberg, G., Andreasen, L., Christophersen, I.E., Hansen, C.C., Møller, S., Hellsten, Y., Haunsoe, S., Tveit, A., Svendsen, J.H., Gotthardt, M., Lundegaard, P.R. and Olesen, M.S.
JACC: Basic to Translational Science 9 (2): 163-180. February 2024

SERCA2a microdomain cAMP changes in heart failure with preserved ejection fraction.
Gotthardt, M. and Lehnart, S.E.
Cardiovascular Research 120 (3): 220-222. February 2024

2023

Cardiac splicing as a diagnostic and therapeutic target.
Gotthardt, M., Badillo Lisakowski, V., Parikh, V.N., Ashley, E., Furtado, M., Carmo-Fonseca, M., Schudy, S., Meder, B., Grosch, M., Steinmetz, L., Crocini, C. and Leinwand, L.
Nature Reviews Cardiology 20 (8): 517-530. August 2023

Mislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3.
Kornienko, J., Rodríguez-Martínez, M., Fenzl, K., Hinze, F., Schraivogel, D., Grosch, M., Tunaj, B., Lindenhofer, D., Schraft, L., Kueblbeck, M., Smith, E., Mao, C., Brown, E., Owens, A., Saguner, A.M., Meder, B., Parikh, V., Gotthardt, M. and Steinmetz, L.M.
Nature Communications 14 (1): 4312. 18 July 2023

Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy.
Grosch, M., Schraft, L., Chan, A., Küchenhoff, L., Rapti, K., Ferreira, A.M., Kornienko, J., Li, S., Radke, M.H., Krämer, C., Clauder-Münster, S., Perlas, E., Backs, J., Gotthardt, M., Dieterich, C., van den Hoogenhof, M.M.G., Grimm, D. and Steinmetz, L.M.
Nature Communications 14 (1): 3714. 22 June 2023

Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames.
Sandmann, C.L., Schulz, J.F., Ruiz-Orera, J., Kirchner, M., Ziehm, M., Adami, E., Marczenke, M., Christ, A., Liebe, N., Greiner, J., Schoenenberger, A., Mücke, M.B., Liang, N., Moritz, R.L., Sun, Z., Deutsch, E.W., Gotthardt, M., Mudge, J.M., Prensner, J.R., Willnow, T.E., Mertins, P., van Heesch, S. and Hubner, N.
Molecular Cell 83 (6): 994-1011.e18. 16 March 2023

CAR links hypoxia signaling to improved survival after myocardial infarction.
Freiberg, F., Thakkar, M., Hamann, W., Lopez Carballo, J., Jüttner, R., Voss, F.K., Becher, P.M., Westermann, D., Tschöpe, C., Heuser, A., Rocks, O., Fischer, R. and Gotthardt, M.
Experimental and Molecular Medicine 55 (3): 643-652. March 2023

Disease- and sex-specific differences in patients with heart valve disease: a proteome study.
Nordmeyer, S., Kraus, M., Ziehm, M., Kirchner, M., Schafstedde, M., Kelm, M., Niquet, S., Stephen, M.M., Baczko, I., Knosalla, C., Schapranow, M.P., Dittmar, G., Gotthardt, M., Falcke, M., Regitz-Zagrosek, V., Kuehne, T. and Mertins, P.
Life Science Alliance 6 (3): e202201411. March 2023

A single-cell RNA labeling strategy for measuring stress response upon tissue dissociation.
Neuschulz, A., Bakina, O., Badillo Lisakowski, V., Olivares-Chauvet, P., Conrad, T., Gotthardt, M., Kettenmann, H. and Junker, J.P.
Molecular Systems Biology 19 (2): e11147. 10 February 2023

The IgCAM CAR regulates gap junction-mediated coupling on embryonic cardiomyocytes and affects their beating frequency.
Matthaeus, C., Jüttner, R., Gotthardt, M. and Rathjen, F.G.
Life 13 (1): 14. January 2023

2022

Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation.
Ortiz-Zapater, E., Bagley, D.C., Hernandez, V.L., Roberts, L.B., Maguire, T.J.A., Voss, F., Mertins, P., Kirchner, M., Peset-Martin, I., Woszczek, G., Rosenblatt, J., Gotthardt, M., Santis, G. and Parsons, M.
Nature Communications 13 (1): 6407. 27 October 2022

Proteome-wide quantitative RNA-interactome capture identifies phosphorylation sites with regulatory potential in RBM20.
Vieira e Vieira, C.H., Dauksaite, V., Sporbert, A., Gotthardt, M. and Selbach, M.
Molecular Cell 82 (11): 2069-2083. 2 June 2022

HDAC6 modulates myofibril stiffness and diastolic function of the heart.
Lin, Y.H., Major, J.L., Liebner, T., Hourani, Z., Travers, J.G., Wennersten, S.A., Haefner, K.R., Cavasin, M.A., Wilson, C.E., Jeong, M.Y., Han, Y., Gotthardt, M., Ferguson, S.K., Ambardekar, A.V., Lam, M.P., Choudhary, C., Granzier, H.L., Woulfe, K.C. and McKinsey, T.A.
Journal of Clinical Investigation 132 (10): e148333. 16 May 2022

RBM20 phosphorylation and its role in nucleocytoplasmic transport and cardiac pathogenesis.
Zhang, Y., Wang, C., Sun, M., Jin, Y., Braz, C.U., Khatib, H., Hacker, T.A., Liss, M., Gotthardt, M., Granzier, H., Ge, Y. and Guo, W.
FASEB Journal 36 (5): e22302. May 2022

Regression from pathological hypertrophy in mice is sexually dimorphic and stimulus-specific.
Muehleman, D.L., Crocini, C., Swearingen, A.R., Ozeroff, C.D. and Leinwand, L.A.
American Journal of Physiology Heart and Circulatory Physiology 322 (5): H785-H797. May 2022

SLM2 is a novel cardiac splicing factor involved in heart failure due to dilated cardiomyopathy.
Boeckel, J.N., Möbius-Winkler, M., Müller, M., Rebs, S., Eger, N., Schoppe, L., Tappu, R., Kokot, K.E., Kneuer, J.M., Gaul, S., Bordalo, D.M., Lai, A., Haas, J., Ghanbari, M., Drewe-Boss, P., Liss, M., Katus, H.A., Ohler, U., Gotthardt, M., Laufs, U., Streckfuss-Bömeke, K. and Meder, B.
Genomics Proteomics & Bioinformatics 20 (1): 129-146. February 2022

2021

Therapeutic inhibition of RBM20 improves diastolic function in a murine heart failure model and human engineered heart tissue.
Radke, M.H., Badillo-Lisakowski, V., Britto-Borges, T., Kubli, D.A., Jüttner, R., Parakkat, P., Lopez Carballo, J., Hüttemeister, J., Liss, M., Hansen, A., Dieterich, C., Mullick, A.E. and Gotthardt, M.
Science Translational Medicine 13 (622): eabe8952. December 2021

Cardiac sarcomere mechanics in health and disease.
Crocini, C. and Gotthardt, M.
Biophysical Reviews 13 (5): 637-652. October 2021

RBM20-related cardiomyopathy: current understanding and future options.
Koelemen, J., Gotthardt, M., Steinmetz, L.M. and Meder, B.
Journal of Clinical Medicine 10 (18): 4101. 2 September 2021

Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes.
Bathe-Peters, M., Gmach, P., Boltz, H.H., Einsiedel, J., Gotthardt, M., Hübner, H., Gmeiner, P., Lohse, M.J. and Annibale, P.
Proceedings of the National Academy of Sciences of the United States of America 118 (23): e2101119118. 8 June 2021

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G., Rybak-Wolf, A., Lisowski, P., Pentimalli, T.M., Jüttner, R., Glažar, P., Uppal, K., Bottani, E., Brunetti, D., Secker, C., Zink, A., Meierhofer, D., Henke, M.T., Dey, M., Ciptasari, U., Mlody, B., Hahn, T., Berruezo-Llacuna, M., Karaiskos, N., Di Virgilio, M., Mayr, J.A., Wortmann, S.B., Priller, J., Gotthardt, M., Jones, D.P., Mayatepek, E., Stenzel, W., Diecke, S., Kühn, R., Wanker, E.E., Rajewsky, N., Schuelke, M. and Prigione, A.
Nature Communications 12 (1): 1929. 26 March 2021

Caveolin3 stabilizes McT1-mediated lactate/proton transport in cardiomyocytes.
Peper, J., Kownatzki-Danger, D., Weninger, G., Seibertz, F., Pronto, J.R., Sutanto, H., Pacheu Grau, D., Hindmarsh, R., Brandenburg, S., Kohl, T., Hasenfuβ, G., Gotthardt, M., Rog-Zielinska, E.A., Wollnik, B., Rehling, P., Urlaub, H., Wegener, J.W., Heijman, J., Voigt, N., Cyganek, L., Lenz, C. and Lehnart, S.E.
Circulation Research 128 (6): e102-e120. 19 March 2021

An immune-related lncRNA signature to predict survival in glioma patients.
Xia, P., Li, Q., Wu, G. and Huang, Y.
Cellular and Molecular Neurobiology 41 (2): 365-375. March 2021

Wnt signalling pathway in bladder cancer.
Wu, G., Weng, W., Xia, P., Yan, S., Zhong, C., Xie, L., Xie, Y. and Fan, G.
Cellular Signalling 79 : 109886. March 2021

A systematic review and meta- analysis of green-light laser vaporization for superficial bladder cancer.
Xu, Z., Gan, G., Chen, G. and Wu, G.
Urology Journal 17 (6): 578-586. January 2021

Identification of unique long non-coding RNAs as putative biomarkers for chromophobe renal cell carcinoma.
Wu, G., Xia, P., Yan, S., Chen, D., Xie, L. and Fan, G.
Personalized Medicine 18 (1): 9-19. January 2021

2020

Assessment of nanoindentation in stiffness measurement of soft biomaterials: kidney, liver, spleen and uterus.
Wu, G., Gotthardt, M. and Gollasch, M.
Scientific Reports 10 (1): 18784. 2 November 2020

Identification of glioma cancer stem cell characteristics based on weighted gene prognosis module co-expression network analysis of transcriptome data stemness indices.
Xia, P., Li, Q., Wu, G. and Huang, Y.
Journal of Molecular Neuroscience 70 (10): 1512-1520. October 2020

RBM20 phosphorylation on serine/arginine domain is crucial to regulate pre-mRNA splicing and protein shuttling in the heart.
Sun, M., Jin, Y., Zhu, C., Zhang, Y., Liss, M., Gotthardt, M., Ren, J., Ge, Y. and Guo, W.
bioRxiv : 2020.09.15.297002. 15 September 2020

iPSC modeling of RBM20-deficient DCM identifies upregulation of RBM20 as a therapeutic strategy.
Briganti, F., Sun, H., Wei, W., Wu, J., Zhu, C., Liss, M., Karakikes, I., Rego, S., Cipriano, A., Snyder, M., Meder, B., Xu, Z., Millat, G., Gotthardt, M., Mercola, M. and Steinmetz, L.M.
Cell Reports 32 (10): 108117. 8 September 2020

Deconstructing sarcomeric structure-function relations in titin-BioID knock-in mice.
Rudolph, F., Fink, C., Hüttemeister, J., Kirchner, M., Radke, M.H., Lopez Carballo, J., Wagner, E., Kohl, T., Lehnart, S.E., Mertins, P. and Gotthardt, M.
Nature Communications 11 (1): 3133. 19 June 2020

Effects of hemodialysis on plasma oxylipins.
Gollasch, B., Wu, G., Dogan, I., Rothe, M., Gollasch, M. and Luft, F.C.
Physiological Reports 8 (12): e14447. June 2020

Deleting titin's C-terminal PEVK exons increases passive stiffness, alters splicing, and induces cross-sectional and longitudinal hypertrophy in skeletal muscle.
van der Pijl, R.J., Hudson, B., Granzier-Nakajima, T., Li, F., Knottnerus, A.M., Smith, J., Chung, C.S., Gotthardt, M., Granzier, H.L. and Ottenheijm, C.A.C.
Frontiers in Physiology 11 (1): 494. 29 May 2020

NNT-AS1 enhances bladder cancer cell growth by targeting miR-1301-3p/PODXL axis and activating Wnt pathway.
Liu, Y. and Wu, G.
Neurourology and Urodynamics 39 (2): 547-557. February 2020

Real-time visualization of titin dynamics reveals extensive reversible photobleaching in human induced pluripotent stem cell-derived cardiomyocytes.
Cadar, A.G., Feaster, T.K., Bersell, K.R., Wang, L., Hong, T.T., Balsamo, J.A., Zhang, Z., Chun, Y.W., Nam, Y.J., Gotthardt, M., Knollmann, B.C., Roden, D.M., Lim, C.C. and Hong, C.C.
American Journal of Physiology Cell Physiology 318 (1): C163-C173. January 2020

2019

Proteomic and transcriptomic changes in hibernating grizzly bears reveal metabolic and signaling pathways that protect against muscle atrophy.
Mugahid, D.A., Sengul, T.G., You, X., Wang, Y., Steil, L., Bergmann, N., Radke, M.H., Ofenbauer, A., Gesell-Salazar, M., Balogh, A., Kempa, S., Tursun, B., Robbins, C.T., Völker, U., Chen, W., Nelson, L. and Gotthardt, M.
Scientific Reports 9 (1): 19976. 27 December 2019

Microtubule cytoskeleton regulates connexin 43 localization and cardiac conduction in cardiomyopathy caused by mutation in A-type lamins gene.
Macquart, C., Jüttner, R., Le Dour, C., Chatzifrangkeskou, M., Schmitt, A., Gotthardt, M., Bonne, G. and Muchir, A.
Human Molecular Genetics 28 (24): 4043-4052. 15 December 2019

Resolving titin's lifecycle and the spatial organization of protein turnover in mouse cardiomyocytes.
Rudolph, F., Hüttemeister, J., da Silva Lopes, K., Jüttner, R., Yu, L., Bergmann, N., Friedrich, D., Preibisch, S., Wagner, E., Lehnart, S.E., Gregorio, C.C. and Gotthardt, M.
Proceedings of the National Academy of Sciences of the United States of America 116 (50): 25126-25136. 10 December 2019

Maximal exercise and erythrocyte epoxy fatty acids: a lipidomics study.
Gollasch, B., Wu, G., Dogan, I., Rothe, M., Gollasch, M. and Luft, F.C.
Physiological Reports 7 (22): e14275. November 2019

Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction.
Friebel, J., Weithauser, A., Witkowski, M., Rauch, B.H., Savvatis, K., Dörner, A., Tabaraie, T., Kasner, M., Moos, V., Bösel, D., Gotthardt, M., Radke, M.H., Wegner, M., Bobbert, P., Lassner, D., Tschöpe, C., Schutheiss, H.P., Felix, S.B., Landmesser, U. and Rauch, U.
European Heart Journal 40 (40): 3318-3332. 21 October 2019

Clinical relevance of semaphorin-3F in patients with prostate cancer.
Wu, G.
Clinical and Investigative Medicine 42 (3): E64-E69. 29 September 2019

The cell adhesion protein CAR is a negative regulator of synaptic transmission.
Wrackmeyer, U., Kaldrack, J., Jüttner, R., Pannasch, U., Gimber, N., Freiberg, F., Purfürst, B., Kainmueller, D., Schmitz, D., Haucke, V., Rathjen, F.G. and Gotthardt, M.
Scientific Reports 9 (1): 6768. 1 May 2019

Deleting full length titin versus the titin M-band region leads to differential mechanosignaling and cardiac phenotypes.
Radke, M.H., Polack, C., Methawasin, M., Fink, C., Granzier, H.L. and Gotthardt, M.
Circulation 139 (15): 1813-1827. 9 April 2019

Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance.
Slater, R.E., Strom, J.G., Methawasin, Mei, Liss, M., Gotthardt, M., Sweitzer, N. and Granzier, H.L.
Journal of General Physiology 151 (1): 42-52. January 2019

2018

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.
Liss, M., Radke, M.H., Eckhard, J., Neuenschwander, M., Dauksaite, V., von Kries, J.P. and Gotthardt, M.
PLoS ONE 13 (6): e0198492. 11 June 2018

Molecular basis of titin exon exclusion by RBM20 and the novel titin splice regulator PTB4.
Dauksaite, V. and Gotthardt, M.
Nucleic Acids Research 46 (10): 5227-5238. 1 June 2018

Expanding the map of protein-RNA interaction sites via cell fusion followed by PAR-CLIP.
Hinze, F., Drewe-Boss, P., Milek, M., Ohler, U., Landthaler, M. and Gotthardt, M.
RNA Biology 15 (3): 359-368. 4 March 2018

2017

Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy.
Sedaghat-Hamedani, F., Haas, J., Zhu, F., Geier, C., Kayvanpour, E., Liss, M., Lai, A., Frese, K., Pribe-Wolferts, R., Amr, A., Li, D.T., Samani, O.S., Carstensen, A., Bordalo, D.M., Müller, M., Fischer, C., Shao, J., Wang, J., Nie, M., Yuan, L., Haßfeld, S., Schwartz, C., Zhou, M., Zhou, Z., Shu, Y., Wang, M., Huang, K., Zeng, Q., Cheng, L., Fehlmann, T., Ehlermann, P., Keller, A., Dieterich, C., Streckfuß-Bömeke, K., Liao, Y., Gotthardt, M., Katus, H.A. and Meder, B.
European Heart Journal 38 (46): 3449-3460. 7 December 2017

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.
Park, T.J., Reznick, J., Peterson, B.L., Blass, G., Omerbašić, D., Bennett, N.C., Kuich, P.H.J.L., Zasada, C., Browe, B.M., Hamann, W., Applegate, D.T., Radke, M.H., Kosten, T., Lutermann, H., Gavaghan, V., Eigenbrod, O., Bégay, V., Amoroso, V. G., Govind, V., Minshall, R.D., Smith, E.S.J., Larson, J., Gotthardt, M., Kempa, S. and Lewin, G.R.
Science 356 (6335): 307-311. 21 April 2017

2016

Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy.
Hinze, F., Dieterich, C., Radke, M.H., Granzier, H. and Gotthardt, M.
Journal of Molecular Medicine 94 (12): 1349-1358. December 2016

Axial tubule junctions control rapid calcium signaling in atria.
Brandenburg, S., Kohl, T., Williams, G.S.B., Gusev, K., Wagner, E., Rog-Zielinska, E.A., Hebisch, E., Dura, M., Didié, M., Gotthardt, M., Nikolaev, V.O., Hasenfuss, G., Kohl, P., Ward, C.W., Lederer, W.J. and Lehnart, S.E.
Journal of Clinical Investigation 126 (10): 3999-4015. 3 October 2016

2015

Podocyte-specific deletion of murine CXADR does not impair podocyte development, function or stress response.
Schell, C., Kretz, O., Bregenzer, A., Rogg, M., Helmstädter, M., Lisewski, U., Gotthardt, M., Tharaux, P.L., Huber, T.B. and Grahammer, F.
PLoS ONE 10 (6): e0129424. 15 June 2015

The Src Homology and Collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/Z-disk network during heart development.
Mlih, M., Host, L., Martin, S., Niederhoffer, N., Monassier, L., Terrand, J., Messaddeq, N., Radke, M., Gotthardt, M., Bruban, V., Kober, F., Bernard, M., Canet-Soulas, E., Abt-Jijon, F., Boucher, P. and Matz, R.L.
Journal of Biological Chemistry 290 (4): 2419-2430. 23 January 2015

Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease.
Roberts, A.M., Ware, J.S., Herman, D.S., Schafer, S., Baksi, J., Bick, A.G., Buchan, R.J., Walsh, R., John, S., Wilkinson, S., Mazzarotto, F., Felkin, L.E., Gong, S., MacArthur, J.A.L., Cunningham, F., Flannick, J., Gabriel, S.B., Altshuler, D.M., Macdonald, P.S., Heinig, M., Keogh, A.M., Hayward, C.S., Banner, N.R., Pennell, D.J., O'Regan, D.P., San, T.R., de Marvao, A., Dawes, T.J.W., Gulati, A., Birks, E.J., Yacoub, M.H., Radke, M., Gotthardt, M., Wilson, J.G., O'Donnell, C.J., Prasad, S.K., Barton, P.J.R., Fatkin, D., Hubner, N., Seidman, J.G., Seidman, C.E. and Cook, S.A.
Science Translational Medicine 7 (270): 270ra6. 14 January 2015

2014

Moderate inappropriately high aldosterone/NaCl constellation in mice: cardiovascular effects and the role of cardiovascular epidermal growth factor receptor.
Schreier, B., Rabe, S., Winter, S., Ruhs, S., Mildenberger, S., Schneider, B., Sibilia, M., Gotthardt, M., Kempe, S., Mäder, K., Grossmann, C. and Gekle, M.
Scientific Reports 4 : 7430. 11 December 2014

Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics.
Elhamine, F., Radke, M., Pfitzer, G., Granzier, H., Gotthardt, M. and Stehle, R.
Journal of Cell Science 127 (Pt 17): 3666-3674. 1 September 2014

RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing.
Maatz, H., Jens, M., Liss, M., Schafer, S., Heinig, M., Kirchner, M., Adami, E., Rintisch, C., Dauksaite, V., Radke, M.H., Selbach, M., Barton, P.J.R., Cook, S.A., Rajewsky, N., Gotthardt, M., Landthaler, M. and Hubner, N.
Journal of Clinical Investigation 124 (8): 3419-3430. 1 August 2014

Interspecies differences in virus uptake versus cardiac function of the coxsackievirus and adenovirus receptor.
Freiberg, F., Sauter, M., Pinkert, S., Govindarajan, T., Kaldrack, J., Thakkar, M., Fechner, H., Klingel, K. and Gotthardt, M.
Journal of Virology 88 (13): 7345-7356. 1 July 2014

Coxsackie and adenovirus receptor (CAR) is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia.
Marsman, R.F.J., Bezzina, C.R., Freiberg, F., Verkerk, A.O., Adriaens, M.E., Podliesna, S., Chen, C., Purfürst, B., Spallek, B., Koopmann, T.T., Baczko, I., Dos Remedios, C.G., George, A.L., Bishopric, N.H., Lodder, E.M., de Bakker, J.M.T., Fischer, R., Coronel, R., Wilde, A.A.M., Gotthardt, M. and Remme, C.A.
Journal of the American College of Cardiology 63 (6): 549-559. 18 February 2014

Recessive TTN truncating mutations define novel forms of core myopathy with heart disease.
Chauveau, C., Bonnemann, C.G., Julien, C., Kho, A.L., Marks, H., Talim, B., Maury, P., Arne-Bes, M.C., Uro-Coste, E., Alexandrovich, A., Vihola, A., Schafer, S., Kaufmann, B., Medne, L., Hübner, N., Foley, A.R., Santi, M., Udd, B., Topaloglu, H., Moore, S.A., Gotthardt, M., Samuels, M.E., Gautel, M. and Ferreiro, A.
Human Molecular Genetics 23 (4): 980-991. 15 February 2014

2013

Calcium sensitivity and myofilament lattice structure in titin N2B KO mice.
Lee, E.J., Nedrud, J., Schemmel, P., Gotthardt, M., Irving, T.C. and Granzier, H.L.
Archives of Biochemistry and Biophysics 535 (1): 76-83. 1 July 2013

Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy.
Schreier, B., Rabe, S., Schneider, B., Bretschneider, M., Rupp, S., Ruhs, S., Neumann, J., Rueckschloss, U., Sibilia, M., Gotthardt, M., Grossmann, C. and Gekle, M.
Hypertension 61 (2): 333-340. February 2013

2012

RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing.
Guo, W., Schafer, S., Greaser, M.L., Radke, M.H., Liss, M., Govindarajan, T., Maatz, H., Schulz, H., Lincoln, S.E., Parrish, A.M., Dauksaite, V., Vakeel, P., Klaassen, S., Gerull, B., Thierfelder, L., Regitz-Zagrosek, V., Hacker, T.A., Saupe, K.W., Dec, G.W., Ellinor, P.T., MacRae, C.A., Spallek, B., Fischer, R., Perrot, A., Ozcelik, C., Saar, K., Hubner, N. and Gotthardt, M.
Nature Medicine 18 (5): 766-773. May 2012

2011

Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycle.
Nedrud, J., Labeit, S., Gotthardt, M. and Granzier, H.
Biophysical Journal 101 (6): 1385-1392. 21 September 2011

Titin based viscosity in ventricular physiology: An integrative investigation of PEVK-actin interactions.
Chung, C.S., Methawasin, M., Nelson, O.L., Radke, M.H., Hidalgo, C.G., Gotthardt, M. and Granzier, H.L.
Journal of Molecular and Cellular Cardiology 51 (3): 428-434. September 2011

Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1.
Schreier, B., Doehler, M., Rabe, S., Schneider, B., Schwerdt, G., Ruhs, S., Sibilia, M., Gotthardt, M., Gekle, M. and Grossmann, C.
Arteriosclerosis Thrombosis and Vascular Biology 31 (7): 1643-1652. July 2011

Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres.
da Silva Lopes, K., Pietas, A., Radke, M.H. and Gotthardt, M.
Journal of Cell Biology 193 (4): 785-798. 16 May 2011

2010

Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region deficient mice.
Lee, E.J., Peng, J., Radke, M., Gotthardt, M. and Granzier, H.L.
Journal of Molecular and Cellular Cardiology 49 (3): 449-458. September 2010

Excision of titin's cardiac PEVK spring element abolishes PKCalpha-induced increases in myocardial stiffness.
Hudson, B.D., Hidalgo, C.G., Gotthardt, M. and Granzier, H.L.
Journal of Molecular and Cellular Cardiology 48 (5): 972-978. May 2010

2009

Altered contractility of skeletal muscle in mice deficient in titin's M-band region.
Ottenheijm, C.A., Hidalgo, C., Rost, K., Gotthardt, M. and Granzier, H.
Journal of Molecular Biology 393 (1): 10-26. 16 October 2009

Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction.
Granzier, H.L., Radke, M.H., Peng, J., Westermann, D., Nelson, O.L., Rost, K., King, N.M., Yu, Q., Tschoepe, C., McNabb, M., Larson, D.F., Labeit, S. and Gotthardt, M.
Circulation Research 105 (6): 557-564. 11 September 2009

CAR-diology - a virus receptor in the healthy and diseased heart.
Fischer, R., Poller, W., Schultheiss, H.P. and Gotthardt, M.
Journal of Molecular Medicine 87 (9): 879-884. September 2009

Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure.
Westermann, D., Riad, A., Richter, U., Jaeger, S., Savvatis, K., Schuchardt, M., Bergmann, N., Toelle, M., Nagorsen, D., Gotthardt, M., Schultheiss, H.P. and Tschoepe, C.
Basic Research in Cardiology 104 (5): 499-509. September 2009

Cardiac deletion of the coxsackievirus-adenovirus receptor abolishes coxsackievirus b3 infection and prevents myocarditis in vivo.
Shi, Y., Chen, C., Lisewski, U., Wrackmeyer, U., Radke, M., Westermann, D., Sauter, M., Tschoepe, C., Poller, W., Klingel, K. and Gotthardt, M.
Journal of the American College of Cardiology 53 (14): 1219-1226. 7 April 2009

2008

The tight junction protein CAR regulates cardiac conduction and cell-cell communication.
Lisewski, U., Shi, Y., Wrackmeyer, U., Fischer, R., Chen, C., Schirdewan, A., Juettner, R., Rathjen, F.G., Poller, W., Radke, M.H. and Gotthardt, M.
Journal of Experimental Medicine 205 (10): 2369-2379. 29 September 2008

Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis.
Lukowski, R., Weinmeister, P., Bernhard, D., Feil, S., Gotthardt, M., Herz, J., Massberg, S., Zernecke, A., Weber, C., Hofmann, F. and Feil, R.
Arteriosclerosis Thrombosis and Vascular Biology 28 (7): 1244-1250. July 2008

A proteome map of murine heart and skeletal muscle.
Raddatz, K., Albrecht, D., Hochgraefe, F., Hecker, M. and Gotthardt, M.
Proteomics 8 (9): 1885-1897. May 2008

2007

Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.
Jansen, P., Giehl, K., Nyengaard, J.R., Teng, K., Lioubinski, O., Sjoegaard, S.S., Breiderhoff, T., Gotthardt, M., Lin, F., Eilers, A., Petersen, C.M., Lewin, G.R., Hempstead, B.L., Willnow, T.E. and Nykjaer, A.
Nature Neuroscience 10 (11): 1449-1457. November 2007

Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle.
Granzier, H., Radke, M., Royal, J., Wu, Y., Irving, T.C., Gotthardt, M. and Labeit, S.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 293 (2): R557-R567. 1 August 2007

Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy.
Radke, M.H., Peng, J., Wu, Y., McNabb, M., Nelson, O.L., Granzier, H. and Gotthardt, M.
Proceedings of the National Academy of Sciences of the United States of America 104 (9): 3444-3449. 27 February 2007

Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region.
Peng, J., Raddatz, K., Molkentin, J.D., Wu, Y., Labeit, S., Granzier, H. and Gotthardt, M.
Circulation 115 (6): 743-751. 13 February 2007

2006

Titin M-line deficiency causes impaired myofibril maturation and cardiac dysfunction.
Weinert, S.
UNSPECIFIED thesis, UNSPECIFIED. 22 September 2006

M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere.
Weinert, S., Bergmann, N., Luo, X., Erdmann, B. and Gotthardt, M.
Journal of Cell Biology 173 (4): 559-570. 22 May 2006

Cardiac signaling: cellular, molecular and clinical aspects.
Gotthardt, M. and Raddatz, K.
In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 1. Springer, Berlin [u.a.], 208-214. ISBN 3-540-44244-8 2006

2005

Muscle atrophy in titin M-line deficient mice.
Peng, J., Raddatz, K., Labeit, S., Granzier, H. and Gotthardt, M.
Journal of Muscle Research and Cell Motility 26 (6-8): 381-388. 1 December 2005

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Andersen, O.M., Reiche, J., Schmidt, V., Gotthardt, M., Spoelgen, R., Behlke, J., von Arnim, C.A.F., Breiderhoff, T., Jansen, P., Wu, X., Bales, K.R., Cappai, R., Masters, C.L., Gliemann, J., Mufson, E.J., Hyman, B.T., Paul, S.M., Nykjaer, A. and Willnow, T.E.
Proceedings of the National Academy of Sciences of the United States of America 102 (38): 13461-13466. 7 September 2005

2004

Induzierbare ortsspezifische Mutagenese durch bedingte Genrettung [Inducible site-directed mutagenesis through conditional gene rescue].
Gotthardt, M. and Radke, M.
EP1466974 ; WO0470042. 13 October 2004

LRP and PDGF signaling: a pathway to atherosclerosis.
Boucher, P. and Gotthardt, M.
Trends in Cardiovascular Medicine 14 (2): 55-60. February 2004

Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling.
Witt, C.C., Ono, Y., Puschmann, E., McNabb, M., Wu, Y., Gotthardt, M., Witt, S.H., Haak, M., Labeit, D., Gregorio, C.C., Sorimachi, H., Granzier, H. and Labeit, S.
Journal of Molecular Biology 336 : 145-154. 1 January 2004

2003

LRP: role in vascular wall integrity and protection from atherosclerosis.
Boucher, P., Gotthardt, M., Li, W.P., Anderson, R.G. and Herz, J.
Science 300 : 329-332. 11 April 2003

Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure.
Gotthardt, M., Hammer, R.E., Hübner, N., Monti, J., Witt, C.C., McNabb, M., Richardson, J.A., Granzier, H., Labeit, S. and Herz, J.
Journal of Biological Chemistry 278 (8): 6059-6065. 21 February 2003

Adaptations in titin's spring elements in normal and cardiomyopathic hearts.
Granzier, H., Labeit, D., Wu, Y., Witt, C., Watanabe, K., Lahmers, S., Gotthardt, M. and Labeit, S.
Advances in Experimental Medicine and Biology 538 (538): 517-530; discussion 530-531. 2003

2002

LDL receptor signaling pathways.
Herz, J. and Gotthardt, M.
US6,428,967. 6 August 2002

Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure.
Holtwick, R., Gotthardt, M., Skryabin, B., Steinmetz, M., Potthast, R., Zetsche, B., Hammer, R.E., Herz, J. and Kuhn, M.
Proceedings of the National Academy of Sciences of the United States of America 99 : 7142-7147. 14 May 2002

Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low Density lipoprotein receptor-related protein in caveolae.
Boucher, P., Liu, P., Gotthardt, M., Hiesberger, T., Anderson, R.G. and Herz, J.
Journal of Biological Chemistry 277 : 15507-15513. 3 May 2002

Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice.
Vasandani, C., Kafrouni, A.I., Caronna, A., Bashmakov, Y., Gotthardt, M., Horton, J.D. and Spady, D.K.
Journal of Lipid Research 43 : 772-784. 1 May 2002

2001

The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system.
Bang, M.L., Centner, T., Fornoff, F., Geach, A.J., Gotthardt, M., McNabb, M., Witt, C.C., Labeit, D., Gregorio, C.C., Granzier, H. and Labeit, S.
Circulation Research 89 : 1065-1072. 23 November 2001

2000

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.
Gotthardt, M., Trommsdorff, M., Nevitt, M.F., Shelton, J., Richardson, J.A., Stockinger, W., Nimpf, J. and Herz, J.
Journal of Biological Chemistry 275 (33): 25616-25624. 18 August 2000

The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2.
Stockinger, W., Brandes, C., Fasching, D., Hermann, M., Gotthardt, M., Herz, J., Schneider, W.J. and Nimpf, J.
Journal of Biological Chemistry 275 (33): 25625-25632. 18 August 2000

Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor.
Schmitz, C., Gotthardt, M., Hinderlich, S., Leheste, J.R., Gross, V., Vorum, H., Christensen, E.I., Luft, F.C., Takahashi, S. and Willnow, T.E.
Journal of Biological Chemistry 275 (20): 15357-15362. 19 May 2000

Cellular signalling by lipoprotein receptors.
Herz, J., Gotthardt, M. and Willnow, T.E.
Current Opinion in Lipidology 11 (2): 161-166. 1 April 2000

1999

Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.
Trommsdorff, M., Gotthardt, M., Hiesberger, T., Shelton, J., Stockinger, W., Nimpf, J., Hammer, R.E., Richardson, J.A. and Herz, J.
Cell 97 (6): 689-701. 11 June 1999

1998

Inducible inactivation of hepatic LRP gene by Cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants.
Rohlmann, A., Gotthardt, M., Hammer, R.E. and Herz, J.
Journal of Clinical Investigation 101 (3): 689-695. 1 February 1998

1997

Gene therapy for familial hypercholesterolemia.
Gotthardt, M. and Schuster, H.
In: Concepts in gene therapy. de Gruyter, Berlin; New York, 359-386. 1 January 1997

1996

Sustained somatic gene inactivation by viral transfer of Cre recombinase.
Rohlmann, A., Gotthardt, M., Willnow, T.E., Hammer, R.E. and Herz, J.
Nature Biotechnology 14 (11): 1562-1565. 1 November 1996

1994

Moeglichkeiten und Grenzen der Gentherapie.
Gotthardt, M. and Strauss, M.
Monatsschrift fuer Kinderheilkunde 142 : 930-940. 1 January 1994