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2018

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.
Liss, M. and Radke, M.H. and Eckhard, J. and Neuenschwander, M. and Dauksaite, V. and von Kries, J.P. and Gotthardt, M.
PLoS ONE 13 (6): e0198492. 11 June 2018

Microtubule cytoskeleton regulates connexin 43 localization and cardiac conduction in cardiomyopathy caused by mutation in A-type lamins gene.
Macquart, C. and Jüttner, R. and Le Dour, C. and Chatzifrangkeskou, M. and Schmitt, A. and Gotthardt, M. and Bonne, G. and Muchir, A.
Human Molecular Genetics 8 June 2018 (In Press)

Molecular basis of titin exon exclusion by RBM20 and the novel titin splice regulator PTB4.
Dauksaite, V. and Gotthardt, M.
Nucleic Acids Research 46 (10): 5227-5238. 1 June 2018

Expanding the map of protein-RNA interaction sites via cell fusion followed by PAR-CLIP.
Hinze, F. and Drewe-Boss, P. and Milek, M. and Ohler, U. and Landthaler, M. and Gotthardt, M.
RNA Biology 15 (3): 359-368. 4 March 2018

2017

Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy.
Sedaghat-Hamedani, F. and Haas, J. and Zhu, F. and Geier, C. and Kayvanpour, E. and Liss, M. and Lai, A. and Frese, K. and Pribe-Wolferts, R. and Amr, A. and Li, D.T. and Samani, O.S. and Carstensen, A. and Bordalo, D.M. and Müller, M. and Fischer, C. and Shao, J. and Wang, J. and Nie, M. and Yuan, L. and Haßfeld, S. and Schwartz, C. and Zhou, M. and Zhou, Z. and Shu, Y. and Wang, M. and Huang, K. and Zeng, Q. and Cheng, L. and Fehlmann, T. and Ehlermann, P. and Keller, A. and Dieterich, C. and Streckfuß-Bömeke, K. and Liao, Y. and Gotthardt, M. and Katus, H.A. and Meder, B.
European Heart Journal 38 (46): 3449-3460. 7 December 2017

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.
Park, T.J. and Reznick, J. and Peterson, B.L. and Blass, G. and Omerbašić, D. and Bennett, N.C. and Kuich, P.H.J.L. and Zasada, C. and Browe, B.M. and Hamann, W. and Applegate, D.T. and Radke, M.H. and Kosten, T. and Lutermann, H. and Gavaghan, V. and Eigenbrod, O. and Bégay, V. and Amoroso, V. G. and Govind, V. and Minshall, R.D. and Smith, E.S.J. and Larson, J. and Gotthardt, M. and Kempa, S. and Lewin, G.R.
Science 356 (6335): 307-311. 21 April 2017

2016

Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy.
Hinze, F. and Dieterich, C. and Radke, M.H. and Granzier, H. and Gotthardt, M.
Journal of Molecular Medicine 94 (12): 1349-1358. December 2016

Axial tubule junctions control rapid calcium signaling in atria.
Brandenburg, S. and Kohl, T. and Williams, G.S.B. and Gusev, K. and Wagner, E. and Rog-Zielinska, E.A. and Hebisch, E. and Dura, M. and Didié, M. and Gotthardt, M. and Nikolaev, V.O. and Hasenfuss, G. and Kohl, P. and Ward, C.W. and Lederer, W.J. and Lehnart, S.E.
Journal of Clinical Investigation 126 (10): 3999-4015. 3 October 2016

2015

Podocyte-specific deletion of murine CXADR does not impair podocyte development, function or stress response.
Schell, C. and Kretz, O. and Bregenzer, A. and Rogg, M. and Helmstädter, M. and Lisewski, U. and Gotthardt, M. and Tharaux, P.L. and Huber, T.B. and Grahammer, F.
PLoS ONE 10 (6): e0129424. 15 June 2015

The Src Homology and Collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/Z-disk network during heart development.
Mlih, M. and Host, L. and Martin, S. and Niederhoffer, N. and Monassier, L. and Terrand, J. and Messaddeq, N. and Radke, M. and Gotthardt, M. and Bruban, V. and Kober, F. and Bernard, M. and Canet-Soulas, E. and Abt-Jijon, F. and Boucher, P. and Matz, R.L.
Journal of Biological Chemistry 290 (4): 2419-2430. 23 January 2015

Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease.
Roberts, A.M. and Ware, J.S. and Herman, D.S. and Schafer, S. and Baksi, J. and Bick, A.G. and Buchan, R.J. and Walsh, R. and John, S. and Wilkinson, S. and Mazzarotto, F. and Felkin, L.E. and Gong, S. and MacArthur, J.A.L. and Cunningham, F. and Flannick, J. and Gabriel, S.B. and Altshuler, D.M. and Macdonald, P.S. and Heinig, M. and Keogh, A.M. and Hayward, C.S. and Banner, N.R. and Pennell, D.J. and O'Regan, D.P. and San, T.R. and de Marvao, A. and Dawes, T.J.W. and Gulati, A. and Birks, E.J. and Yacoub, M.H. and Radke, M. and Gotthardt, M. and Wilson, J.G. and O'Donnell, C.J. and Prasad, S.K. and Barton, P.J.R. and Fatkin, D. and Hubner, N. and Seidman, J.G. and Seidman, C.E. and Cook, S.A.
Science Translational Medicine 7 (270): 270ra6. 14 January 2015

2014

Moderate inappropriately high aldosterone/NaCl constellation in mice: cardiovascular effects and the role of cardiovascular epidermal growth factor receptor.
Schreier, B. and Rabe, S. and Winter, S. and Ruhs, S. and Mildenberger, S. and Schneider, B. and Sibilia, M. and Gotthardt, M. and Kempe, S. and Mäder, K. and Grossmann, C. and Gekle, M.
Scientific Reports 4 : 7430. 11 December 2014

Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics.
Elhamine, F. and Radke, M. and Pfitzer, G. and Granzier, H. and Gotthardt, M. and Stehle, R.
Journal of Cell Science 127 (Pt 17): 3666-3674. 1 September 2014

RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing.
Maatz, H. and Jens, M. and Liss, M. and Schafer, S. and Heinig, M. and Kirchner, M. and Adami, E. and Rintisch, C. and Dauksaite, V. and Radke, M.H. and Selbach, M. and Barton, P.J.R. and Cook, S.A. and Rajewsky, N. and Gotthardt, M. and Landthaler, M. and Hubner, N.
Journal of Clinical Investigation 124 (8): 3419-3430. 1 August 2014

Interspecies differences in virus uptake versus cardiac function of the coxsackievirus and adenovirus receptor.
Freiberg, F. and Sauter, M. and Pinkert, S. and Govindarajan, T. and Kaldrack, J. and Thakkar, M. and Fechner, H. and Klingel, K. and Gotthardt, M.
Journal of Virology 88 (13): 7345-7356. 1 July 2014

Coxsackie and adenovirus receptor (CAR) is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia.
Marsman, R.F.J. and Bezzina, C.R. and Freiberg, F. and Verkerk, A.O. and Adriaens, M.E. and Podliesna, S. and Chen, C. and Purfürst, B. and Spallek, B. and Koopmann, T.T. and Baczko, I. and Dos Remedios, C.G. and George, A.L. and Bishopric, N.H. and Lodder, E.M. and de Bakker, J.M.T. and Fischer, R. and Coronel, R. and Wilde, A.A.M. and Gotthardt, M. and Remme, C.A.
Journal of the American College of Cardiology 63 (6): 549-559. 18 February 2014

Recessive TTN truncating mutations define novel forms of core myopathy with heart disease.
Chauveau, C. and Bonnemann, C.G. and Julien, C. and Kho, A.L. and Marks, H. and Talim, B. and Maury, P. and Arne-Bes, M.C. and Uro-Coste, E. and Alexandrovich, A. and Vihola, A. and Schafer, S. and Kaufmann, B. and Medne, L. and Hübner, N. and Foley, A.R. and Santi, M. and Udd, B. and Topaloglu, H. and Moore, S.A. and Gotthardt, M. and Samuels, M.E. and Gautel, M. and Ferreiro, A.
Human Molecular Genetics 23 (4): 980-991. 15 February 2014

2013

Calcium sensitivity and myofilament lattice structure in titin N2B KO mice.
Lee, E.J. and Nedrud, J. and Schemmel, P. and Gotthardt, M. and Irving, T.C. and Granzier, H.L.
Archives of Biochemistry and Biophysics 535 (1): 76-83. 1 July 2013

Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy.
Schreier, B. and Rabe, S. and Schneider, B. and Bretschneider, M. and Rupp, S. and Ruhs, S. and Neumann, J. and Rueckschloss, U. and Sibilia, M. and Gotthardt, M. and Grossmann, C. and Gekle, M.
Hypertension 61 (2): 333-340. February 2013

2012

RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing.
Guo, W. and Schafer, S. and Greaser, M.L. and Radke, M.H. and Liss, M. and Govindarajan, T. and Maatz, H. and Schulz, H. and Lincoln, S.E. and Parrish, A.M. and Dauksaite, V. and Vakeel, P. and Klaassen, S. and Gerull, B. and Thierfelder, L. and Regitz-Zagrosek, V. and Hacker, T.A. and Saupe, K.W. and Dec, G.W. and Ellinor, P.T. and MacRae, C.A. and Spallek, B. and Fischer, R. and Perrot, A. and Ozcelik, C. and Saar, K. and Hubner, N. and Gotthardt, M.
Nature Medicine 18 (5): 766-773. May 2012

2011

Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycle.
Nedrud, J. and Labeit, S. and Gotthardt, M. and Granzier, H.
Biophysical Journal 101 (6): 1385-1392. 21 September 2011

Titin based viscosity in ventricular physiology: An integrative investigation of PEVK-actin interactions.
Chung, C.S. and Methawasin, M. and Nelson, O.L. and Radke, M.H. and Hidalgo, C.G. and Gotthardt, M. and Granzier, H.L.
Journal of Molecular and Cellular Cardiology 51 (3): 428-434. September 2011

Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1.
Schreier, B. and Doehler, M. and Rabe, S. and Schneider, B. and Schwerdt, G. and Ruhs, S. and Sibilia, M. and Gotthardt, M. and Gekle, M. and Grossmann, C.
Arteriosclerosis Thrombosis and Vascular Biology 31 (7): 1643-1652. July 2011

Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres.
da Silva Lopes, K. and Pietas, A. and Radke, M.H. and Gotthardt, M.
Journal of Cell Biology 193 (4): 785-798. 16 May 2011

2010

Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region deficient mice.
Lee, E.J. and Peng, J. and Radke, M. and Gotthardt, M. and Granzier, H.L.
Journal of Molecular and Cellular Cardiology 49 (3): 449-458. September 2010

Excision of titin's cardiac PEVK spring element abolishes PKCalpha-induced increases in myocardial stiffness.
Hudson, B.D. and Hidalgo, C.G. and Gotthardt, M. and Granzier, H.L.
Journal of Molecular and Cellular Cardiology 48 (5): 972-978. May 2010

2009

Altered contractility of skeletal muscle in mice deficient in titin's M-band region.
Ottenheijm, C.A. and Hidalgo, C. and Rost, K. and Gotthardt, M. and Granzier, H.
Journal of Molecular Biology 393 (1): 10-26. 16 October 2009

Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction.
Granzier, H.L. and Radke, M.H. and Peng, J. and Westermann, D. and Nelson, O.L. and Rost, K. and King, N.M. and Yu, Q. and Tschoepe, C. and McNabb, M. and Larson, D.F. and Labeit, S. and Gotthardt, M.
Circulation Research 105 (6): 557-564. 11 September 2009

CAR-diology - a virus receptor in the healthy and diseased heart.
Fischer, R. and Poller, W. and Schultheiss, H.P. and Gotthardt, M.
Journal of Molecular Medicine 87 (9): 879-884. September 2009

Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure.
Westermann, D. and Riad, A. and Richter, U. and Jaeger, S. and Savvatis, K. and Schuchardt, M. and Bergmann, N. and Toelle, M. and Nagorsen, D. and Gotthardt, M. and Schultheiss, H.P. and Tschoepe, C.
Basic Research in Cardiology 104 (5): 499-509. September 2009

Cardiac deletion of the coxsackievirus-adenovirus receptor abolishes coxsackievirus b3 infection and prevents myocarditis in vivo.
Shi, Y. and Chen, C. and Lisewski, U. and Wrackmeyer, U. and Radke, M. and Westermann, D. and Sauter, M. and Tschoepe, C. and Poller, W. and Klingel, K. and Gotthardt, M.
Journal of the American College of Cardiology 53 (14): 1219-1226. 7 April 2009

2008

The tight junction protein CAR regulates cardiac conduction and cell-cell communication.
Lisewski, U. and Shi, Y. and Wrackmeyer, U. and Fischer, R. and Chen, C. and Schirdewan, A. and Juettner, R. and Rathjen, F.G. and Poller, W. and Radke, M.H. and Gotthardt, M.
Journal of Experimental Medicine 205 (10): 2369-2379. 29 September 2008

Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis.
Lukowski, R. and Weinmeister, P. and Bernhard, D. and Feil, S. and Gotthardt, M. and Herz, J. and Massberg, S. and Zernecke, A. and Weber, C. and Hofmann, F. and Feil, R.
Arteriosclerosis Thrombosis and Vascular Biology 28 (7): 1244-1250. July 2008

A proteome map of murine heart and skeletal muscle.
Raddatz, K. and Albrecht, D. and Hochgraefe, F. and Hecker, M. and Gotthardt, M.
Proteomics 8 (9): 1885-1897. May 2008

2007

Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.
Jansen, P. and Giehl, K. and Nyengaard, J.R. and Teng, K. and Lioubinski, O. and Sjoegaard, S.S. and Breiderhoff, T. and Gotthardt, M. and Lin, F. and Eilers, A. and Petersen, C.M. and Lewin, G.R. and Hempstead, B.L. and Willnow, T.E. and Nykjaer, A.
Nature Neuroscience 10 (11): 1449-1457. November 2007

Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle.
Granzier, H.L. and Radke, M. and Royal, J. and Wu, Y. and Irving, T.C. and Gotthardt, M. and Labeit, S.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 293 (2): R557-R567. 1 August 2007

Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy.
Radke, M.H. and Peng, J. and Wu, Y. and McNabb, M. and Nelson, O.L. and Granzier, H. and Gotthardt, M.
Proceedings of the National Academy of Sciences of the United States of America 104 (9): 3444-3449. 27 February 2007

Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region.
Peng, J. and Raddatz, K. and Molkentin, J.D. and Wu, Y. and Labeit, S. and Granzier, H. and Gotthardt, M.
Circulation 115 (6): 743-751. 13 February 2007

2006

Titin M-line deficiency causes impaired myofibril maturation and cardiac dysfunction.
Weinert, S.
UNSPECIFIED thesis, UNSPECIFIED. 22 September 2006

M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere.
Weinert, S. and Bergmann, N. and Luo, X. and Erdmann, B. and Gotthardt, M.
Journal of Cell Biology 173 (4): 559-570. 22 May 2006

Cardiac signaling: cellular, molecular and clinical aspects.
Gotthardt, M. and Raddatz, K.
In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 1. Springer, Berlin [u.a.], 208-214. ISBN 3-540-44244-8 2006

2005

Muscle atrophy in titin M-line deficient mice.
Peng, J. and Raddatz, K. and Labeit, S. and Granzier, H. and Gotthardt, M.
Journal of Muscle Research and Cell Motility 26 (6-8): 381-388. 1 December 2005

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Andersen, O.M. and Reiche, J. and Schmidt, V. and Gotthardt, M. and Spoelgen, R. and Behlke, J. and von Arnim, C.A.F. and Breiderhoff, T. and Jansen, P. and Wu, X. and Bales, K.R. and Cappai, R. and Masters, C.L. and Gliemann, J. and Mufson, E.J. and Hyman, B.T. and Paul, S.M. and Nykjaer, A. and Willnow, T.E.
Proceedings of the National Academy of Sciences of the United States of America 102 (38): 13461-13466. 7 September 2005

2004

Induzierbare ortsspezifische Mutagenese durch bedingte Genrettung [Inducible site-directed mutagenesis through conditional gene rescue].
Gotthardt, M. and Radke, M.
EP1466974 ; WO0470042. 13 October 2004

LRP and PDGF signaling: a pathway to atherosclerosis.
Boucher, P. and Gotthardt, M.
Trends in Cardiovascular Medicine 14 (2): 55-60. February 2004

Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling.
Witt, C.C. and Ono, Y. and Puschmann, E. and McNabb, M. and Wu, Y. and Gotthardt, M. and Witt, S.H. and Haak, M. and Labeit, D. and Gregorio, C.C. and Sorimachi, H. and Granzier, H. and Labeit, S.
Journal of Molecular Biology 336 : 145-154. 1 January 2004

2003

LRP: role in vascular wall integrity and protection from atherosclerosis.
Boucher, P. and Gotthardt, M. and Li, W.P. and Anderson, R.G. and Herz, J.
Science 300 : 329-332. 11 April 2003

Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure.
Gotthardt, M. and Hammer, R.E. and Huebner, N. and Monti, J. and Witt, C.C. and McNabb, M. and Richardson, J.A. and Granzier, H. and Labeit, S. and Herz, J.
Journal of Biological Chemistry 278 (8): 6059-6065. 21 February 2003

Adaptations in titin's spring elements in normal and cardiomyopathic hearts.
Granzier, H. and Labeit, D. and Wu, Y. and Witt, C. and Watanabe, K. and Lahmers, S. and Gotthardt, M. and Labeit, S.
Advances in Experimental Medicine and Biology 538 (538): 517-530; discussion 530-531. 2003

2002

LDL receptor signaling pathways.
Herz, J. and Gotthardt, M.
US6,428,967. 6 August 2002

Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure.
Holtwick, R. and Gotthardt, M. and Skryabin, B. and Steinmetz, M. and Potthast, R. and Zetsche, B. and Hammer, R.E. and Herz, J. and Kuhn, M.
Proceedings of the National Academy of Sciences of the United States of America 99 : 7142-7147. 14 May 2002

Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low Density lipoprotein receptor-related protein in caveolae.
Boucher, P. and Liu, P. and Gotthardt, M. and Hiesberger, T. and Anderson, R.G. and Herz, J.
Journal of Biological Chemistry 277 : 15507-15513. 3 May 2002

Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice.
Vasandani, C. and Kafrouni, A.I. and Caronna, A. and Bashmakov, Y. and Gotthardt, M. and Horton, J.D. and Spady, D.K.
Journal of Lipid Research 43 : 772-784. 1 May 2002

2001

The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system.
Bang, M.L. and Centner, T. and Fornoff, F. and Geach, A.J. and Gotthardt, M. and McNabb, M. and Witt, C.C. and Labeit, D. and Gregorio, C.C. and Granzier, H. and Labeit, S.
Circulation Research 89 : 1065-1072. 23 November 2001

2000

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.
Gotthardt, M. and Trommsdorff, M. and Nevitt, M.F. and Shelton, J. and Richardson, J.A. and Stockinger, W. and Nimpf, J. and Herz, J.
Journal of Biological Chemistry 275 (33): 25616-25624. 18 August 2000

The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2.
Stockinger, W. and Brandes, C. and Fasching, D. and Hermann, M. and Gotthardt, M. and Herz, J. and Schneider, W.J. and Nimpf, J.
Journal of Biological Chemistry 275 (33): 25625-25632. 18 August 2000

Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor.
Schmitz, C. and Gotthardt, M. and Hinderlich, S. and Leheste, J.R. and Gross, V. and Vorum, H. and Christensen, E.I. and Luft, F.C. and Takahashi, S. and Willnow, T.E.
Journal of Biological Chemistry 275 (20): 15357-15362. 19 May 2000

Cellular signalling by lipoprotein receptors.
Herz, J. and Gotthardt, M. and Willnow, T.E.
Current Opinion in Lipidology 11 (2): 161-166. 1 April 2000

1999

Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.
Trommsdorff, M. and Gotthardt, M. and Hiesberger, T. and Shelton, J. and Stockinger, W. and Nimpf, J. and Hammer, R.E. and Richardson, J.A. and Herz, J.
Cell 97 (6): 689-701. 11 June 1999

1998

Inducible inactivation of hepatic LRP gene by Cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants.
Rohlmann, A. and Gotthardt, M. and Hammer, R.E. and Herz, J.
Journal of Clinical Investigation 101 (3): 689-695. 1 February 1998

1997

Gene therapy for familial hypercholesterolemia.
Gotthardt, M. and Schuster, H.
In: Concepts in gene therapy. de Gruyter, Berlin; New York, 359-386. 1 January 1997

1996

Sustained somatic gene inactivation by viral transfer of Cre recombinase.
Rohlmann, A. and Gotthardt, M. and Willnow, T.E. and Hammer, R.E. and Herz, J.
Nature Biotechnology 14 (11): 1562-1565. 1 November 1996

1994

Moeglichkeiten und Grenzen der Gentherapie.
Gotthardt, M. and Strauss, M.
Monatsschrift fuer Kinderheilkunde 142 : 930-940. 1 January 1994

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