Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Browse by Research Team

Export as [feed] Atom [feed] RSS 1.0 [feed] RSS 2.0
Group by: Date | Item Type | Source
Jump to: Advances in Experimental Medicine and Biology | American Journal of Physiology Cell Physiology | American Journal of Physiology Heart and Circulatory Physiology | American Journal of Physiology. Regulatory, Integrative and Comparative Physiology | Archives of Biochemistry and Biophysics | Arteriosclerosis Thrombosis and Vascular Biology | Basic Research in Cardiology | Biophysical Journal | Biophysical Reviews | Cardiovascular research | Cell | Cell Reports | Cellular Signalling | Cellular and Molecular Neurobiology | Circulation | Circulation Research | Clinical and Investigative Medicine | Current Opinion in Lipidology | European Heart Journal | Experimental and Molecular Medicine | FASEB Journal | Frontiers in Physiology | Genomics Proteomics & Bioinformatics | Human Molecular Genetics | Hypertension | JACC: Basic to Translational Science | Journal of Biological Chemistry | Journal of Cell Biology | Journal of Cell Science | Journal of Clinical Investigation | Journal of Clinical Medicine | Journal of Experimental Medicine | Journal of General Physiology | Journal of Lipid Research | Journal of Molecular Biology | Journal of Molecular Medicine | Journal of Molecular Neuroscience | Journal of Molecular and Cellular Cardiology | Journal of Muscle Research and Cell Motility | Journal of Virology | Journal of the American College of Cardiology | Life | Life Science Alliance | Molecular Cell | Molecular Systems Biology | Monatsschrift fuer Kinderheilkunde | Nature Biotechnology | Nature Communications | Nature Medicine | Nature Neuroscience | Nature Reviews Cardiology | Neurourology and Urodynamics | Nucleic Acids Research | PLoS ONE | Personalized Medicine | Physiological Reports | Proceedings of the National Academy of Sciences of the United States of America | Proteomics | RNA Biology | Science | Science Translational Medicine | Scientific Reports | Trends in Cardiovascular Medicine | Urology Journal | bioRxiv

Advances in Experimental Medicine and Biology

Adaptations in titin's spring elements in normal and cardiomyopathic hearts.
Granzier, H. and Labeit, D. and Wu, Y. and Witt, C. and Watanabe, K. and Lahmers, S. and Gotthardt, M. and Labeit, S.
Advances in Experimental Medicine and Biology 538 (538): 517-530; discussion 530-531. 2003

American Journal of Physiology Cell Physiology

Real-time visualization of titin dynamics reveals extensive reversible photobleaching in human induced pluripotent stem cell-derived cardiomyocytes.
Cadar, A.G. and Feaster, T.K. and Bersell, K.R. and Wang, L. and Hong, T.T. and Balsamo, J.A. and Zhang, Z. and Chun, Y.W. and Nam, Y.J. and Gotthardt, M. and Knollmann, B.C. and Roden, D.M. and Lim, C.C. and Hong, C.C.
American Journal of Physiology Cell Physiology 318 (1): C163-C173. January 2020

American Journal of Physiology Heart and Circulatory Physiology

Regression from pathological hypertrophy in mice is sexually dimorphic and stimulus-specific.
Muehleman, D.L. and Crocini, C. and Swearingen, A.R. and Ozeroff, C.D. and Leinwand, L.A.
American Journal of Physiology Heart and Circulatory Physiology 322 (5): H785-H797. May 2022

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology

Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle.
Granzier, H. and Radke, M. and Royal, J. and Wu, Y. and Irving, T.C. and Gotthardt, M. and Labeit, S.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 293 (2): R557-R567. 1 August 2007

Archives of Biochemistry and Biophysics

Calcium sensitivity and myofilament lattice structure in titin N2B KO mice.
Lee, E.J. and Nedrud, J. and Schemmel, P. and Gotthardt, M. and Irving, T.C. and Granzier, H.L.
Archives of Biochemistry and Biophysics 535 (1): 76-83. 1 July 2013

Arteriosclerosis Thrombosis and Vascular Biology

Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1.
Schreier, B. and Doehler, M. and Rabe, S. and Schneider, B. and Schwerdt, G. and Ruhs, S. and Sibilia, M. and Gotthardt, M. and Gekle, M. and Grossmann, C.
Arteriosclerosis Thrombosis and Vascular Biology 31 (7): 1643-1652. July 2011

Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis.
Lukowski, R. and Weinmeister, P. and Bernhard, D. and Feil, S. and Gotthardt, M. and Herz, J. and Massberg, S. and Zernecke, A. and Weber, C. and Hofmann, F. and Feil, R.
Arteriosclerosis Thrombosis and Vascular Biology 28 (7): 1244-1250. July 2008

Basic Research in Cardiology

Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure.
Westermann, D. and Riad, A. and Richter, U. and Jaeger, S. and Savvatis, K. and Schuchardt, M. and Bergmann, N. and Toelle, M. and Nagorsen, D. and Gotthardt, M. and Schultheiss, H.P. and Tschoepe, C.
Basic Research in Cardiology 104 (5): 499-509. September 2009

Biophysical Journal

Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycle.
Nedrud, J. and Labeit, S. and Gotthardt, M. and Granzier, H.
Biophysical Journal 101 (6): 1385-1392. 21 September 2011

Biophysical Reviews

Cardiac sarcomere mechanics in health and disease.
Crocini, C. and Gotthardt, M.
Biophysical Reviews 13 (5): 637-652. October 2021

Cardiovascular research

SERCA2a microdomain cAMP changes in heart failure with preserved ejection fraction.
Gotthardt, M. and Lehnart, S.E.
Cardiovascular research 120 (3): 220-222. February 2024

Cell

Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.
Trommsdorff, M. and Gotthardt, M. and Hiesberger, T. and Shelton, J. and Stockinger, W. and Nimpf, J. and Hammer, R.E. and Richardson, J.A. and Herz, J.
Cell 97 (6): 689-701. 11 June 1999

Cell Reports

iPSC modeling of RBM20-deficient DCM identifies upregulation of RBM20 as a therapeutic strategy.
Briganti, F. and Sun, H. and Wei, W. and Wu, J. and Zhu, C. and Liss, M. and Karakikes, I. and Rego, S. and Cipriano, A. and Snyder, M. and Meder, B. and Xu, Z. and Millat, G. and Gotthardt, M. and Mercola, M. and Steinmetz, L.M.
Cell Reports 32 (10): 108117. 8 September 2020

Cellular Signalling

Wnt signalling pathway in bladder cancer.
Wu, G. and Weng, W. and Xia, P. and Yan, S. and Zhong, C. and Xie, L. and Xie, Y. and Fan, G.
Cellular Signalling 79 : 109886. March 2021

Cellular and Molecular Neurobiology

An immune-related lncRNA signature to predict survival in glioma patients.
Xia, P. and Li, Q. and Wu, G. and Huang, Y.
Cellular and Molecular Neurobiology 41 (2): 365-375. March 2021

Circulation

Deleting full length titin versus the titin M-band region leads to differential mechanosignaling and cardiac phenotypes.
Radke, M.H. and Polack, C. and Methawasin, M. and Fink, C. and Granzier, H.L. and Gotthardt, M.
Circulation 139 (15): 1813-1827. 9 April 2019

Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region.
Peng, J. and Raddatz, K. and Molkentin, J.D. and Wu, Y. and Labeit, S. and Granzier, H. and Gotthardt, M.
Circulation 115 (6): 743-751. 13 February 2007

Circulation Research

Caveolin3 stabilizes McT1-mediated lactate/proton transport in cardiomyocytes.
Peper, J. and Kownatzki-Danger, D. and Weninger, G. and Seibertz, F. and Pronto, J.R. and Sutanto, H. and Pacheu Grau, D. and Hindmarsh, R. and Brandenburg, S. and Kohl, T. and Hasenfuβ, G. and Gotthardt, M. and Rog-Zielinska, E.A. and Wollnik, B. and Rehling, P. and Urlaub, H. and Wegener, J.W. and Heijman, J. and Voigt, N. and Cyganek, L. and Lenz, C. and Lehnart, S.E.
Circulation Research 128 (6): e102-e120. 19 March 2021

Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction.
Granzier, H.L. and Radke, M.H. and Peng, J. and Westermann, D. and Nelson, O.L. and Rost, K. and King, N.M. and Yu, Q. and Tschoepe, C. and McNabb, M. and Larson, D.F. and Labeit, S. and Gotthardt, M.
Circulation Research 105 (6): 557-564. 11 September 2009

The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system.
Bang, M.L. and Centner, T. and Fornoff, F. and Geach, A.J. and Gotthardt, M. and McNabb, M. and Witt, C.C. and Labeit, D. and Gregorio, C.C. and Granzier, H. and Labeit, S.
Circulation Research 89 : 1065-1072. 23 November 2001

Clinical and Investigative Medicine

Clinical relevance of semaphorin-3F in patients with prostate cancer.
Wu, G.
Clinical and Investigative Medicine 42 (3): E64-E69. 29 September 2019

Current Opinion in Lipidology

Cellular signalling by lipoprotein receptors.
Herz, J. and Gotthardt, M. and Willnow, T.E.
Current Opinion in Lipidology 11 (2): 161-166. 1 April 2000

European Heart Journal

Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction.
Friebel, J. and Weithauser, A. and Witkowski, M. and Rauch, B.H. and Savvatis, K. and Dörner, A. and Tabaraie, T. and Kasner, M. and Moos, V. and Bösel, D. and Gotthardt, M. and Radke, M.H. and Wegner, M. and Bobbert, P. and Lassner, D. and Tschöpe, C. and Schutheiss, H.P. and Felix, S.B. and Landmesser, U. and Rauch, U.
European Heart Journal 40 (40): 3318-3332. 21 October 2019

Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy.
Sedaghat-Hamedani, F. and Haas, J. and Zhu, F. and Geier, C. and Kayvanpour, E. and Liss, M. and Lai, A. and Frese, K. and Pribe-Wolferts, R. and Amr, A. and Li, D.T. and Samani, O.S. and Carstensen, A. and Bordalo, D.M. and Müller, M. and Fischer, C. and Shao, J. and Wang, J. and Nie, M. and Yuan, L. and Haßfeld, S. and Schwartz, C. and Zhou, M. and Zhou, Z. and Shu, Y. and Wang, M. and Huang, K. and Zeng, Q. and Cheng, L. and Fehlmann, T. and Ehlermann, P. and Keller, A. and Dieterich, C. and Streckfuß-Bömeke, K. and Liao, Y. and Gotthardt, M. and Katus, H.A. and Meder, B.
European Heart Journal 38 (46): 3449-3460. 7 December 2017

Experimental and Molecular Medicine

CAR links hypoxia signaling to improved survival after myocardial infarction.
Freiberg, F. and Thakkar, M. and Hamann, W. and Lopez Carballo, J. and Jüttner, R. and Voss, F.K. and Becher, P.M. and Westermann, D. and Tschöpe, C. and Heuser, A. and Rocks, O. and Fischer, R. and Gotthardt, M.
Experimental and Molecular Medicine 55 (3): 643-652. March 2023

FASEB Journal

RBM20 phosphorylation and its role in nucleocytoplasmic transport and cardiac pathogenesis.
Zhang, Y. and Wang, C. and Sun, M. and Jin, Y. and Braz, C.U. and Khatib, H. and Hacker, T.A. and Liss, M. and Gotthardt, M. and Granzier, H. and Ge, Y. and Guo, W.
FASEB Journal 36 (5): e22302. May 2022

Frontiers in Physiology

Deleting titin's C-terminal PEVK exons increases passive stiffness, alters splicing, and induces cross-sectional and longitudinal hypertrophy in skeletal muscle.
van der Pijl, R.J. and Hudson, B. and Granzier-Nakajima, T. and Li, F. and Knottnerus, A.M. and Smith, J. and Chung, C.S. and Gotthardt, M. and Granzier, H.L. and Ottenheijm, C.A.C.
Frontiers in Physiology 11 (1): 494. 29 May 2020

Genomics Proteomics & Bioinformatics

SLM2 is a novel cardiac splicing factor involved in heart failure due to dilated cardiomyopathy.
Boeckel, J.N. and Möbius-Winkler, M. and Müller, M. and Rebs, S. and Eger, N. and Schoppe, L. and Tappu, R. and Kokot, K.E. and Kneuer, J.M. and Gaul, S. and Bordalo, D.M. and Lai, A. and Haas, J. and Ghanbari, M. and Drewe-Boss, P. and Liss, M. and Katus, H.A. and Ohler, U. and Gotthardt, M. and Laufs, U. and Streckfuss-Bömeke, K. and Meder, B.
Genomics Proteomics & Bioinformatics 20 (1): 129-146. February 2022

Human Molecular Genetics

Microtubule cytoskeleton regulates connexin 43 localization and cardiac conduction in cardiomyopathy caused by mutation in A-type lamins gene.
Macquart, C. and Jüttner, R. and Le Dour, C. and Chatzifrangkeskou, M. and Schmitt, A. and Gotthardt, M. and Bonne, G. and Muchir, A.
Human Molecular Genetics 28 (24): 4043-4052. 15 December 2019

Recessive TTN truncating mutations define novel forms of core myopathy with heart disease.
Chauveau, C. and Bonnemann, C.G. and Julien, C. and Kho, A.L. and Marks, H. and Talim, B. and Maury, P. and Arne-Bes, M.C. and Uro-Coste, E. and Alexandrovich, A. and Vihola, A. and Schafer, S. and Kaufmann, B. and Medne, L. and Hübner, N. and Foley, A.R. and Santi, M. and Udd, B. and Topaloglu, H. and Moore, S.A. and Gotthardt, M. and Samuels, M.E. and Gautel, M. and Ferreiro, A.
Human Molecular Genetics 23 (4): 980-991. 15 February 2014

Hypertension

Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy.
Schreier, B. and Rabe, S. and Schneider, B. and Bretschneider, M. and Rupp, S. and Ruhs, S. and Neumann, J. and Rueckschloss, U. and Sibilia, M. and Gotthardt, M. and Grossmann, C. and Gekle, M.
Hypertension 61 (2): 333-340. February 2013

JACC: Basic to Translational Science

Loss of cardiac splicing regulator RBM20 is associated with early-onset atrial fibrillation.
Vad, O.B. and Angeli, E. and Liss, M. and Ahlberg, G. and Andreasen, L. and Christophersen, I.E. and Hansen, C.C. and Møller, S. and Hellsten, Y. and Haunsoe, S. and Tveit, A. and Svendsen, J.H. and Gotthardt, M. and Lundegaard, P.R. and Olesen, M.S.
JACC: Basic to Translational Science 9 (2): 163-180. February 2024

Journal of Biological Chemistry

The Src Homology and Collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/Z-disk network during heart development.
Mlih, M. and Host, L. and Martin, S. and Niederhoffer, N. and Monassier, L. and Terrand, J. and Messaddeq, N. and Radke, M. and Gotthardt, M. and Bruban, V. and Kober, F. and Bernard, M. and Canet-Soulas, E. and Abt-Jijon, F. and Boucher, P. and Matz, R.L.
Journal of Biological Chemistry 290 (4): 2419-2430. 23 January 2015

Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure.
Gotthardt, M. and Hammer, R.E. and Hübner, N. and Monti, J. and Witt, C.C. and McNabb, M. and Richardson, J.A. and Granzier, H. and Labeit, S. and Herz, J.
Journal of Biological Chemistry 278 (8): 6059-6065. 21 February 2003

Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low Density lipoprotein receptor-related protein in caveolae.
Boucher, P. and Liu, P. and Gotthardt, M. and Hiesberger, T. and Anderson, R.G. and Herz, J.
Journal of Biological Chemistry 277 : 15507-15513. 3 May 2002

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.
Gotthardt, M. and Trommsdorff, M. and Nevitt, M.F. and Shelton, J. and Richardson, J.A. and Stockinger, W. and Nimpf, J. and Herz, J.
Journal of Biological Chemistry 275 (33): 25616-25624. 18 August 2000

The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2.
Stockinger, W. and Brandes, C. and Fasching, D. and Hermann, M. and Gotthardt, M. and Herz, J. and Schneider, W.J. and Nimpf, J.
Journal of Biological Chemistry 275 (33): 25625-25632. 18 August 2000

Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor.
Schmitz, C. and Gotthardt, M. and Hinderlich, S. and Leheste, J.R. and Gross, V. and Vorum, H. and Christensen, E.I. and Luft, F.C. and Takahashi, S. and Willnow, T.E.
Journal of Biological Chemistry 275 (20): 15357-15362. 19 May 2000

Journal of Cell Biology

Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres.
da Silva Lopes, K. and Pietas, A. and Radke, M.H. and Gotthardt, M.
Journal of Cell Biology 193 (4): 785-798. 16 May 2011

M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere.
Weinert, S. and Bergmann, N. and Luo, X. and Erdmann, B. and Gotthardt, M.
Journal of Cell Biology 173 (4): 559-570. 22 May 2006

Journal of Cell Science

Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics.
Elhamine, F. and Radke, M. and Pfitzer, G. and Granzier, H. and Gotthardt, M. and Stehle, R.
Journal of Cell Science 127 (Pt 17): 3666-3674. 1 September 2014

Journal of Clinical Investigation

HDAC6 modulates myofibril stiffness and diastolic function of the heart.
Lin, Y.H. and Major, J.L. and Liebner, T. and Hourani, Z. and Travers, J.G. and Wennersten, S.A. and Haefner, K.R. and Cavasin, M.A. and Wilson, C.E. and Jeong, M.Y. and Han, Y. and Gotthardt, M. and Ferguson, S.K. and Ambardekar, A.V. and Lam, M.P. and Choudhary, C. and Granzier, H.L. and Woulfe, K.C. and McKinsey, T.A.
Journal of Clinical Investigation 132 (10): e148333. 16 May 2022

Axial tubule junctions control rapid calcium signaling in atria.
Brandenburg, S. and Kohl, T. and Williams, G.S.B. and Gusev, K. and Wagner, E. and Rog-Zielinska, E.A. and Hebisch, E. and Dura, M. and Didié, M. and Gotthardt, M. and Nikolaev, V.O. and Hasenfuss, G. and Kohl, P. and Ward, C.W. and Lederer, W.J. and Lehnart, S.E.
Journal of Clinical Investigation 126 (10): 3999-4015. 3 October 2016

RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing.
Maatz, H. and Jens, M. and Liss, M. and Schafer, S. and Heinig, M. and Kirchner, M. and Adami, E. and Rintisch, C. and Dauksaite, V. and Radke, M.H. and Selbach, M. and Barton, P.J.R. and Cook, S.A. and Rajewsky, N. and Gotthardt, M. and Landthaler, M. and Hubner, N.
Journal of Clinical Investigation 124 (8): 3419-3430. 1 August 2014

Inducible inactivation of hepatic LRP gene by Cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants.
Rohlmann, A. and Gotthardt, M. and Hammer, R.E. and Herz, J.
Journal of Clinical Investigation 101 (3): 689-695. 1 February 1998

Journal of Clinical Medicine

RBM20-related cardiomyopathy: current understanding and future options.
Koelemen, J. and Gotthardt, M. and Steinmetz, L.M. and Meder, B.
Journal of Clinical Medicine 10 (18): 4101. 2 September 2021

Journal of Experimental Medicine

The tight junction protein CAR regulates cardiac conduction and cell-cell communication.
Lisewski, U. and Shi, Y. and Wrackmeyer, U. and Fischer, R. and Chen, C. and Schirdewan, A. and Juettner, R. and Rathjen, F.G. and Poller, W. and Radke, M.H. and Gotthardt, M.
Journal of Experimental Medicine 205 (10): 2369-2379. 29 September 2008

Journal of General Physiology

Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance.
Slater, R.E. and Strom, J.G. and Methawasin, Mei and Liss, M. and Gotthardt, M. and Sweitzer, N. and Granzier, H.L.
Journal of General Physiology 151 (1): 42-52. January 2019

Journal of Lipid Research

Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice.
Vasandani, C. and Kafrouni, A.I. and Caronna, A. and Bashmakov, Y. and Gotthardt, M. and Horton, J.D. and Spady, D.K.
Journal of Lipid Research 43 : 772-784. 1 May 2002

Journal of Molecular Biology

Altered contractility of skeletal muscle in mice deficient in titin's M-band region.
Ottenheijm, C.A. and Hidalgo, C. and Rost, K. and Gotthardt, M. and Granzier, H.
Journal of Molecular Biology 393 (1): 10-26. 16 October 2009

Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling.
Witt, C.C. and Ono, Y. and Puschmann, E. and McNabb, M. and Wu, Y. and Gotthardt, M. and Witt, S.H. and Haak, M. and Labeit, D. and Gregorio, C.C. and Sorimachi, H. and Granzier, H. and Labeit, S.
Journal of Molecular Biology 336 : 145-154. 1 January 2004

Journal of Molecular Medicine

Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy.
Hinze, F. and Dieterich, C. and Radke, M.H. and Granzier, H. and Gotthardt, M.
Journal of Molecular Medicine 94 (12): 1349-1358. December 2016

CAR-diology - a virus receptor in the healthy and diseased heart.
Fischer, R. and Poller, W. and Schultheiss, H.P. and Gotthardt, M.
Journal of Molecular Medicine 87 (9): 879-884. September 2009

Journal of Molecular Neuroscience

Identification of glioma cancer stem cell characteristics based on weighted gene prognosis module co-expression network analysis of transcriptome data stemness indices.
Xia, P. and Li, Q. and Wu, G. and Huang, Y.
Journal of Molecular Neuroscience 70 (10): 1512-1520. October 2020

Journal of Molecular and Cellular Cardiology

Titin based viscosity in ventricular physiology: An integrative investigation of PEVK-actin interactions.
Chung, C.S. and Methawasin, M. and Nelson, O.L. and Radke, M.H. and Hidalgo, C.G. and Gotthardt, M. and Granzier, H.L.
Journal of Molecular and Cellular Cardiology 51 (3): 428-434. September 2011

Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region deficient mice.
Lee, E.J. and Peng, J. and Radke, M. and Gotthardt, M. and Granzier, H.L.
Journal of Molecular and Cellular Cardiology 49 (3): 449-458. September 2010

Excision of titin's cardiac PEVK spring element abolishes PKCalpha-induced increases in myocardial stiffness.
Hudson, B.D. and Hidalgo, C.G. and Gotthardt, M. and Granzier, H.L.
Journal of Molecular and Cellular Cardiology 48 (5): 972-978. May 2010

Journal of Muscle Research and Cell Motility

Muscle atrophy in titin M-line deficient mice.
Peng, J. and Raddatz, K. and Labeit, S. and Granzier, H. and Gotthardt, M.
Journal of Muscle Research and Cell Motility 26 (6-8): 381-388. 1 December 2005

Journal of Virology

Interspecies differences in virus uptake versus cardiac function of the coxsackievirus and adenovirus receptor.
Freiberg, F. and Sauter, M. and Pinkert, S. and Govindarajan, T. and Kaldrack, J. and Thakkar, M. and Fechner, H. and Klingel, K. and Gotthardt, M.
Journal of Virology 88 (13): 7345-7356. 1 July 2014

Journal of the American College of Cardiology

Coxsackie and adenovirus receptor (CAR) is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia.
Marsman, R.F.J. and Bezzina, C.R. and Freiberg, F. and Verkerk, A.O. and Adriaens, M.E. and Podliesna, S. and Chen, C. and Purfürst, B. and Spallek, B. and Koopmann, T.T. and Baczko, I. and Dos Remedios, C.G. and George, A.L. and Bishopric, N.H. and Lodder, E.M. and de Bakker, J.M.T. and Fischer, R. and Coronel, R. and Wilde, A.A.M. and Gotthardt, M. and Remme, C.A.
Journal of the American College of Cardiology 63 (6): 549-559. 18 February 2014

Cardiac deletion of the coxsackievirus-adenovirus receptor abolishes coxsackievirus b3 infection and prevents myocarditis in vivo.
Shi, Y. and Chen, C. and Lisewski, U. and Wrackmeyer, U. and Radke, M. and Westermann, D. and Sauter, M. and Tschoepe, C. and Poller, W. and Klingel, K. and Gotthardt, M.
Journal of the American College of Cardiology 53 (14): 1219-1226. 7 April 2009

Life

The IgCAM CAR regulates gap junction-mediated coupling on embryonic cardiomyocytes and affects their beating frequency.
Matthaeus, C. and Jüttner, R. and Gotthardt, M. and Rathjen, F.G.
Life 13 (1): 14. January 2023

Life Science Alliance

Disease- and sex-specific differences in patients with heart valve disease: a proteome study.
Nordmeyer, S. and Kraus, M. and Ziehm, M. and Kirchner, M. and Schafstedde, M. and Kelm, M. and Niquet, S. and Stephen, M.M. and Baczko, I. and Knosalla, C. and Schapranow, M.P. and Dittmar, G. and Gotthardt, M. and Falcke, M. and Regitz-Zagrosek, V. and Kuehne, T. and Mertins, P.
Life Science Alliance 6 (3): e202201411. March 2023

Molecular Cell

Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames.
Sandmann, C.L. and Schulz, J.F. and Ruiz-Orera, J. and Kirchner, M. and Ziehm, M. and Adami, E. and Marczenke, M. and Christ, A. and Liebe, N. and Greiner, J. and Schoenenberger, A. and Mücke, M.B. and Liang, N. and Moritz, R.L. and Sun, Z. and Deutsch, E.W. and Gotthardt, M. and Mudge, J.M. and Prensner, J.R. and Willnow, T.E. and Mertins, P. and van Heesch, S. and Hubner, N.
Molecular Cell 83 (6): 994-1011.e18. 16 March 2023

Proteome-wide quantitative RNA-interactome capture identifies phosphorylation sites with regulatory potential in RBM20.
Vieira e Vieira, C.H. and Dauksaite, V. and Sporbert, A. and Gotthardt, M. and Selbach, M.
Molecular Cell 82 (11): 2069-2083. 2 June 2022

Molecular Systems Biology

A single-cell RNA labeling strategy for measuring stress response upon tissue dissociation.
Neuschulz, A. and Bakina, O. and Badillo Lisakowski, V. and Olivares-Chauvet, P. and Conrad, T. and Gotthardt, M. and Kettenmann, H. and Junker, J.P.
Molecular Systems Biology 19 (2): e11147. 10 February 2023

Monatsschrift fuer Kinderheilkunde

Moeglichkeiten und Grenzen der Gentherapie.
Gotthardt, M. and Strauss, M.
Monatsschrift fuer Kinderheilkunde 142 : 930-940. 1 January 1994

Nature Biotechnology

Sustained somatic gene inactivation by viral transfer of Cre recombinase.
Rohlmann, A. and Gotthardt, M. and Willnow, T.E. and Hammer, R.E. and Herz, J.
Nature Biotechnology 14 (11): 1562-1565. 1 November 1996

Nature Communications

Mislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3.
Kornienko, J. and Rodríguez-Martínez, M. and Fenzl, K. and Hinze, F. and Schraivogel, D. and Grosch, M. and Tunaj, B. and Lindenhofer, D. and Schraft, L. and Kueblbeck, M. and Smith, E. and Mao, C. and Brown, E. and Owens, A. and Saguner, A.M. and Meder, B. and Parikh, V. and Gotthardt, M. and Steinmetz, L.M.
Nature Communications 14 (1): 4312. 18 July 2023

Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy.
Grosch, M. and Schraft, L. and Chan, A. and Küchenhoff, L. and Rapti, K. and Ferreira, A.M. and Kornienko, J. and Li, S. and Radke, M.H. and Krämer, C. and Clauder-Münster, S. and Perlas, E. and Backs, J. and Gotthardt, M. and Dieterich, C. and van den Hoogenhof, M.M.G. and Grimm, D. and Steinmetz, L.M.
Nature Communications 14 (1): 3714. 22 June 2023

Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation.
Ortiz-Zapater, E. and Bagley, D.C. and Hernandez, V.L. and Roberts, L.B. and Maguire, T.J.A. and Voss, F. and Mertins, P. and Kirchner, M. and Peset-Martin, I. and Woszczek, G. and Rosenblatt, J. and Gotthardt, M. and Santis, G. and Parsons, M.
Nature Communications 13 (1): 6407. 27 October 2022

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G. and Rybak-Wolf, A. and Lisowski, P. and Pentimalli, T.M. and Jüttner, R. and Glažar, P. and Uppal, K. and Bottani, E. and Brunetti, D. and Secker, C. and Zink, A. and Meierhofer, D. and Henke, M.T. and Dey, M. and Ciptasari, U. and Mlody, B. and Hahn, T. and Berruezo-Llacuna, M. and Karaiskos, N. and Di Virgilio, M. and Mayr, J.A. and Wortmann, S.B. and Priller, J. and Gotthardt, M. and Jones, D.P. and Mayatepek, E. and Stenzel, W. and Diecke, S. and Kühn, R. and Wanker, E.E. and Rajewsky, N. and Schuelke, M. and Prigione, A.
Nature Communications 12 (1): 1929. 26 March 2021

Deconstructing sarcomeric structure-function relations in titin-BioID knock-in mice.
Rudolph, F. and Fink, C. and Hüttemeister, J. and Kirchner, M. and Radke, M.H. and Lopez Carballo, J. and Wagner, E. and Kohl, T. and Lehnart, S.E. and Mertins, P. and Gotthardt, M.
Nature Communications 11 (1): 3133. 19 June 2020

Nature Medicine

RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing.
Guo, W. and Schafer, S. and Greaser, M.L. and Radke, M.H. and Liss, M. and Govindarajan, T. and Maatz, H. and Schulz, H. and Lincoln, S.E. and Parrish, A.M. and Dauksaite, V. and Vakeel, P. and Klaassen, S. and Gerull, B. and Thierfelder, L. and Regitz-Zagrosek, V. and Hacker, T.A. and Saupe, K.W. and Dec, G.W. and Ellinor, P.T. and MacRae, C.A. and Spallek, B. and Fischer, R. and Perrot, A. and Ozcelik, C. and Saar, K. and Hubner, N. and Gotthardt, M.
Nature Medicine 18 (5): 766-773. May 2012

Nature Neuroscience

Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.
Jansen, P. and Giehl, K. and Nyengaard, J.R. and Teng, K. and Lioubinski, O. and Sjoegaard, S.S. and Breiderhoff, T. and Gotthardt, M. and Lin, F. and Eilers, A. and Petersen, C.M. and Lewin, G.R. and Hempstead, B.L. and Willnow, T.E. and Nykjaer, A.
Nature Neuroscience 10 (11): 1449-1457. November 2007

Nature Reviews Cardiology

Cardiac splicing as a diagnostic and therapeutic target.
Gotthardt, M. and Badillo Lisakowski, V. and Parikh, V.N. and Ashley, E. and Furtado, M. and Carmo-Fonseca, M. and Schudy, S. and Meder, B. and Grosch, M. and Steinmetz, L. and Crocini, C. and Leinwand, L.
Nature Reviews Cardiology 20 (8): 517-530. August 2023

Neurourology and Urodynamics

NNT-AS1 enhances bladder cancer cell growth by targeting miR-1301-3p/PODXL axis and activating Wnt pathway.
Liu, Y. and Wu, G.
Neurourology and Urodynamics 39 (2): 547-557. February 2020

Nucleic Acids Research

Molecular basis of titin exon exclusion by RBM20 and the novel titin splice regulator PTB4.
Dauksaite, V. and Gotthardt, M.
Nucleic Acids Research 46 (10): 5227-5238. 1 June 2018

PLoS ONE

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.
Liss, M. and Radke, M.H. and Eckhard, J. and Neuenschwander, M. and Dauksaite, V. and von Kries, J.P. and Gotthardt, M.
PLoS ONE 13 (6): e0198492. 11 June 2018

Podocyte-specific deletion of murine CXADR does not impair podocyte development, function or stress response.
Schell, C. and Kretz, O. and Bregenzer, A. and Rogg, M. and Helmstädter, M. and Lisewski, U. and Gotthardt, M. and Tharaux, P.L. and Huber, T.B. and Grahammer, F.
PLoS ONE 10 (6): e0129424. 15 June 2015

Personalized Medicine

Identification of unique long non-coding RNAs as putative biomarkers for chromophobe renal cell carcinoma.
Wu, G. and Xia, P. and Yan, S. and Chen, D. and Xie, L. and Fan, G.
Personalized Medicine 18 (1): 9-19. January 2021

Physiological Reports

Effects of hemodialysis on plasma oxylipins.
Gollasch, B. and Wu, G. and Dogan, I. and Rothe, M. and Gollasch, M. and Luft, F.C.
Physiological Reports 8 (12): e14447. June 2020

Maximal exercise and erythrocyte epoxy fatty acids: a lipidomics study.
Gollasch, B. and Wu, G. and Dogan, I. and Rothe, M. and Gollasch, M. and Luft, F.C.
Physiological Reports 7 (22): e14275. November 2019

Proceedings of the National Academy of Sciences of the United States of America

Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes.
Bathe-Peters, M. and Gmach, P. and Boltz, H.H. and Einsiedel, J. and Gotthardt, M. and Hübner, H. and Gmeiner, P. and Lohse, M.J. and Annibale, P.
Proceedings of the National Academy of Sciences of the United States of America 118 (23): e2101119118. 8 June 2021

Resolving titin's lifecycle and the spatial organization of protein turnover in mouse cardiomyocytes.
Rudolph, F. and Hüttemeister, J. and da Silva Lopes, K. and Jüttner, R. and Yu, L. and Bergmann, N. and Friedrich, D. and Preibisch, S. and Wagner, E. and Lehnart, S.E. and Gregorio, C.C. and Gotthardt, M.
Proceedings of the National Academy of Sciences of the United States of America 116 (50): 25126-25136. 10 December 2019

Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy.
Radke, M.H. and Peng, J. and Wu, Y. and McNabb, M. and Nelson, O.L. and Granzier, H. and Gotthardt, M.
Proceedings of the National Academy of Sciences of the United States of America 104 (9): 3444-3449. 27 February 2007

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Andersen, O.M. and Reiche, J. and Schmidt, V. and Gotthardt, M. and Spoelgen, R. and Behlke, J. and von Arnim, C.A.F. and Breiderhoff, T. and Jansen, P. and Wu, X. and Bales, K.R. and Cappai, R. and Masters, C.L. and Gliemann, J. and Mufson, E.J. and Hyman, B.T. and Paul, S.M. and Nykjaer, A. and Willnow, T.E.
Proceedings of the National Academy of Sciences of the United States of America 102 (38): 13461-13466. 7 September 2005

Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure.
Holtwick, R. and Gotthardt, M. and Skryabin, B. and Steinmetz, M. and Potthast, R. and Zetsche, B. and Hammer, R.E. and Herz, J. and Kuhn, M.
Proceedings of the National Academy of Sciences of the United States of America 99 : 7142-7147. 14 May 2002

Proteomics

A proteome map of murine heart and skeletal muscle.
Raddatz, K. and Albrecht, D. and Hochgraefe, F. and Hecker, M. and Gotthardt, M.
Proteomics 8 (9): 1885-1897. May 2008

RNA Biology

Expanding the map of protein-RNA interaction sites via cell fusion followed by PAR-CLIP.
Hinze, F. and Drewe-Boss, P. and Milek, M. and Ohler, U. and Landthaler, M. and Gotthardt, M.
RNA Biology 15 (3): 359-368. 4 March 2018

Science

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.
Park, T.J. and Reznick, J. and Peterson, B.L. and Blass, G. and Omerbašić, D. and Bennett, N.C. and Kuich, P.H.J.L. and Zasada, C. and Browe, B.M. and Hamann, W. and Applegate, D.T. and Radke, M.H. and Kosten, T. and Lutermann, H. and Gavaghan, V. and Eigenbrod, O. and Bégay, V. and Amoroso, V. G. and Govind, V. and Minshall, R.D. and Smith, E.S.J. and Larson, J. and Gotthardt, M. and Kempa, S. and Lewin, G.R.
Science 356 (6335): 307-311. 21 April 2017

LRP: role in vascular wall integrity and protection from atherosclerosis.
Boucher, P. and Gotthardt, M. and Li, W.P. and Anderson, R.G. and Herz, J.
Science 300 : 329-332. 11 April 2003

Science Translational Medicine

Therapeutic inhibition of RBM20 improves diastolic function in a murine heart failure model and human engineered heart tissue.
Radke, M.H. and Badillo-Lisakowski, V. and Britto-Borges, T. and Kubli, D.A. and Jüttner, R. and Parakkat, P. and Lopez Carballo, J. and Hüttemeister, J. and Liss, M. and Hansen, A. and Dieterich, C. and Mullick, A.E. and Gotthardt, M.
Science Translational Medicine 13 (622): eabe8952. December 2021

Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease.
Roberts, A.M. and Ware, J.S. and Herman, D.S. and Schafer, S. and Baksi, J. and Bick, A.G. and Buchan, R.J. and Walsh, R. and John, S. and Wilkinson, S. and Mazzarotto, F. and Felkin, L.E. and Gong, S. and MacArthur, J.A.L. and Cunningham, F. and Flannick, J. and Gabriel, S.B. and Altshuler, D.M. and Macdonald, P.S. and Heinig, M. and Keogh, A.M. and Hayward, C.S. and Banner, N.R. and Pennell, D.J. and O'Regan, D.P. and San, T.R. and de Marvao, A. and Dawes, T.J.W. and Gulati, A. and Birks, E.J. and Yacoub, M.H. and Radke, M. and Gotthardt, M. and Wilson, J.G. and O'Donnell, C.J. and Prasad, S.K. and Barton, P.J.R. and Fatkin, D. and Hubner, N. and Seidman, J.G. and Seidman, C.E. and Cook, S.A.
Science Translational Medicine 7 (270): 270ra6. 14 January 2015

Scientific Reports

Assessment of nanoindentation in stiffness measurement of soft biomaterials: kidney, liver, spleen and uterus.
Wu, G. and Gotthardt, M. and Gollasch, M.
Scientific Reports 10 (1): 18784. 2 November 2020

Proteomic and transcriptomic changes in hibernating grizzly bears reveal metabolic and signaling pathways that protect against muscle atrophy.
Mugahid, D.A. and Sengul, T.G. and You, X. and Wang, Y. and Steil, L. and Bergmann, N. and Radke, M.H. and Ofenbauer, A. and Gesell-Salazar, M. and Balogh, A. and Kempa, S. and Tursun, B. and Robbins, C.T. and Völker, U. and Chen, W. and Nelson, L. and Gotthardt, M.
Scientific Reports 9 (1): 19976. 27 December 2019

The cell adhesion protein CAR is a negative regulator of synaptic transmission.
Wrackmeyer, U. and Kaldrack, J. and Jüttner, R. and Pannasch, U. and Gimber, N. and Freiberg, F. and Purfürst, B. and Kainmueller, D. and Schmitz, D. and Haucke, V. and Rathjen, F.G. and Gotthardt, M.
Scientific Reports 9 (1): 6768. 1 May 2019

Moderate inappropriately high aldosterone/NaCl constellation in mice: cardiovascular effects and the role of cardiovascular epidermal growth factor receptor.
Schreier, B. and Rabe, S. and Winter, S. and Ruhs, S. and Mildenberger, S. and Schneider, B. and Sibilia, M. and Gotthardt, M. and Kempe, S. and Mäder, K. and Grossmann, C. and Gekle, M.
Scientific Reports 4 : 7430. 11 December 2014

Trends in Cardiovascular Medicine

LRP and PDGF signaling: a pathway to atherosclerosis.
Boucher, P. and Gotthardt, M.
Trends in Cardiovascular Medicine 14 (2): 55-60. February 2004

Urology Journal

A systematic review and meta- analysis of green-light laser vaporization for superficial bladder cancer.
Xu, Z. and Gan, G. and Chen, G. and Wu, G.
Urology Journal 17 (6): 578-586. January 2021

bioRxiv

Proteome-wide quantitative RNA interactome capture (qRIC) identifies phosphorylation sites with regulatory potential in RBM20.
Vieira-Vieira, C.H. and Dauksaite, V. and Gotthardt, M. and Selbach, M.
bioRxiv : 2021.07.12.452044. 12 July 2021

RBM20 phosphorylation on serine/arginine domain is crucial to regulate pre-mRNA splicing and protein shuttling in the heart.
Sun, M. and Jin, Y. and Zhu, C. and Zhang, Y. and Liss, M. and Gotthardt, M. and Ren, J. and Ge, Y. and Guo, W.
bioRxiv : 2020.09.15.297002. 15 September 2020

SURF1 mutations causative of Leigh syndrome impair human neurogenesis.
Inak, G. and Rybak-Wolf, A. and Lisowski, P. and Juettner, R. and Zink, A. and Mlody, B. and Glazar, P. and Secker, C. and Ciptasari, U.H. and Stenzel, W. and Hahn, T. and Diecke, S. and Priller, J. and Gotthardt, M. and Kuehn, R. and Wanker, E.E. and Rajewsky, N. and Schuelke, M. and Prigione, A.
bioRxiv : 551390. 20 February 2019

This list was generated on Thu Mar 28 02:22:10 2024 CET.
Open Access
MDC Library