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2018

Treatment with 5-azacitidine delay growth of glioblastoma xenografts: a potential new treatment approach for glioblastomas.
Kratzsch, T. and Kuhn, S.A. and Joedicke, A. and Hanisch, U.K. and Vajkoczy, P. and Hoffmann, J. and Fichtner, I.
Journal of Cancer Research and Clinical Oncology 144 (5): 809-819. May 2018

Loss-of-function uORF mutations in human malignancies.
Schulz, J. and Mah, N. and Neuenschwander, M. and Kischka, T. and Ratei, R. and Schlag, P.M. and Castaños-Vélez, E. and Fichtner, I. and Tunn, P.U. and Denkert, C. and Klaas, O. and Berdel, W.E. and von Kries, J.P. and Makalowski, W. and Andrade-Navarro, M.A. and Leutz, A. and Wethmar, K.
Scientific Reports 8 (1): 2395. 5 February 2018

2017

Animal models for personalized treatment options.
Fichtner, I. and Klinghammer, K. and Behrens, D. and Flechsig, S. and Rolff, J. and Becker, M. and Wulf-Goldenberg, A. and Stecklum, M. and Rivera, M. and Brzezicha, B. and Jandrig, B. and Hoffmann, J.
International Journal of Clinical Pharmacology and Therapeutics 55 (8): 698-700. August 2017

Pharmacologically directed strategies in academic anticancer drug discovery based on the European NCI compounds initiative.
Hendriks, H.R. and Govaerts, A.S. and Fichtner, I. and Burtles, S. and Westwell, A.D. and Peters, G.J.
British Journal of Cancer 117 (2): 195-202. 11 July 2017

2016

SPON2, a newly identified target gene of MACC1, drives colorectal cancer metastasis in mice and is prognostic for colorectal cancer patient survival.
Schmid, F. and Wang, Q. and Huska, M.R. and Andrade-Navarro, M.A. and Lemm, M. and Fichtner, I. and Dahlmann, M. and Kobelt, D. and Walther, W. and Smith, J. and Schlag, P.M. and Stein, U.
Oncogene 35 (46): 5942-5952. 17 November 2016

Improved treatment of MT-3 breast cancer and brain metastases in a mouse xenograft by LRP-targeted oxaliplatin liposomes.
Orthmann, A. and Peiker, L. and Fichtner, I. and Hoffmann, A. and Hilger, R.A. and Zeisig, R.
Journal of Biomedical Nanotechnology 12 (1): 56-68. January 2016

2015

A comprehensively characterized large panel of head and neck cancer patient-derived xenografts identifies the mTOR inhibitor everolimus as potential new treatment option.
Klinghammer, K. and Raguse, J.D. and Plath, T. and Albers, A.E. and Joehrens, K. and Zakarneh, A. and Brzezicha, B. and Wulf-Goldenberg, A. and Keilholz, U. and Hoffmann, J. and Fichtner, I.
International Journal of Cancer 136 (12): 2940-2948. 15 June 2015

How perifosine affects liposome-encapsulated drug delivery across a cell barrier.
Testen, A and Podlipec, R and Mravljak, J and Orthmann, A and Sentjurc, M and Zeisig, R and Strancar, J and Koklic, T
Therapeutic Delivery 6 (4): 423-441. April 2015

Cell differentiation mediated by co-culture of human umbilical cord blood stem cells with murine hepatic cells.
Stecklum, M. and Wulf-Goldenberg, A. and Purfürst, B. and Siegert, A. and Keil, M. and Eckert, K. and Fichtner, I.
In Vitro Cellular & Developmental Biology Animal 51 (2): 183-191. February 2015

2014

Activation of AMP-activated protein kinase sensitizes lung cancer cells and H1299 xenografts to erlotinib.
Huelsmann, H.J. and Rolff, J. and Bender, C. and Jarahian, M. and Korf, U. and Herwig, R. and Froehlich, H. and Thomas, M. and Merk, J. and Fichtner, I. and Sueltmann, H. and Kuner, R.
Lung Cancer 86 (2): 151-157. November 2014

Antitumor efficacy, pharmacokinetic and biodistribution studies of the anticancer peptide CIGB-552 in mouse models.
Vallespi, M.G. and Pimentel, G. and Cabrales-Rico, A. and Garza, J. and Oliva, B. and Mendoza, O. and Gomez, Y. and Basaco, T. and Sanchez, I. and Calderon, C. and Rodriguez, J.C. and Markelova, M.R. and Fichtner, I. and Astrada, S. and Bollati-Fogolín, M. and Garay, H.E. and Reyes, O.
Journal of Peptide Science 20 (11): 850-859. November 2014

In vitro and in vivo investigations into the carbene copper bromide anticancer drug candidate WBC4.
Walther, W. and Fichtner, I. and Hackenberg, F. and Streciwilk, W. and Tacke, M.
Letters in Drug Design & Discovery 11 (7): 825-832. August 2014

Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assembly.
Belz, K. and Schoeneberger, H. and Wehner, S. and Weigert, A. and Boenig, H. and Klingebiel, T. and Fichtner, I. and Fulda, S.
Blood 124 (2): 240-250. 10 July 2014

Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma.
Friesen, C. and Hormann, I. and Roscher, M. and Fichtner, I. and Alt, A. and Hilger, R. and Debatin, K.M. and Miltner, E.
Cell Cycle 13 (10): 1560-1570. 15 May 2014

The nerve growth factor receptor CD271 is crucial to maintain tumorigenicity and stem-like properties of melanoma cells.
Redmer, T. and Welte, Y. and Behrens, D. and Fichtner, I. and Przybilla, D. and Wruck, W. and Yaspo, M.L. and Lehrach, H. and Schaefer, R. and Regenbrecht, C.R.A.
PLoS ONE 9 (5): e92596. 5 May 2014

Preclinical study on combined chemo- and nonviral gene therapy for sensitization of melanoma using a human TNF-alpha expressing MIDGE DNA vector.
Kobelt, D. and Aumann, J. and Schmidt, M. and Wittig, B. and Fichtner, I. and Behrens, D. and Lemm, M. and Freundt, G. and Schlag, P.M. and Walther, W.
Molecular Oncology 8 (3): 609-619. May 2014

2013

Combined Wnt/β-catenin, met, and CXCL12/CXCR4 signals characterize basal breast cancer and predict disease outcome.
Holland, J.D. and Györffy, B. and Vogel, R. and Eckert, K. and Valenti, G. and Fang, L. and Lohneis, P. and Elezkurtaj, S. and Ziebold, U. and Birchmeier, W.
Cell Reports 5 (5): 1214-1227. 12 December 2013

A seven-year storage report of good manufacturing practice-grade naked plasmid DNA: stability, topology, and in vitro/in vivo functional analysis.
Walther, W. and Schmeer, M. and Kobelt, D. and Baier, R. and Harder, A. and Walhorn, V. and Anselmetti, D. and Aumann, J. and Fichtner, I. and Schleef, M.
Human Gene Therapy Clinical Development 24 (4): 147-153. December 2013

Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Loeschmann, N. and Michaelis, M. and Rothweiler, F. and Zehner, R. and Cinatl, J. and Voges, Y. and Sharifi, M. and Riecken, K. and Meyer, J. and von Deimling, A. and Fichtner, I. and Ghafourian, T. and Westermann, F. and Cinatl Jr., J.
Translational Oncology 6 (6): 685-696. December 2013

Teratoma formation of human embryonic stem cells in three-dimensional perfusion culture bioreactors.
Stachelscheid, H. and Wulf-Goldenberg, A. and Eckert, K. and Jensen, J. and Edsbagge, J. and Bjoerquist, P. and Rivero, M. and Strehl, R. and Jozefczuk, J. and Prigione, A. and Adjaye, J. and Urbaniak, T. and Bussmann, P. and Zeilinger, K. and Gerlach, J.C.
Journal of Tissue Engineering and Regenerative Medicine 7 (9): 729-741. September 2013

Bi-PROF: bisulfite profiling of target regions using 454 GS FLX Titanium technology.
Gries, J. and Schumacher, D. and Arand, J. and Lutsik, P. and Markelova, M.R. and Fichtner, I. and Walter, J. and Sers, C. and Tierling, S.
Epigenetics 8 (7): 765-771. July 2013

The activity of titanocene T against xenografted Caki-1 tumors.
Walther, W. and Fichtner, I. and Deally, A. and Hogan, M. and Tacke, M.
Letters in Drug Design & Discovery 10 (5): 375-381. June 2013

Cell death sensitization of leukemia cells by opioid receptor activation.
Friesen, C. and Roscher, M. and Hormann, I. and Fichtner, I. and Alt, A. and Hilger, R.A. and Debatin, K.M. and Miltner, E.
Oncotarget 4 (5): 677-690. 16 April 2013

Synergistic activity of bortezomib and HDACis in preclinical models of B-cell precursor acute lymphoblastic leukemia via modulation of p53, PI3K/AKT and NF-κB.
Bastian, L. and Hof, J. and Pfau, M. and Fichtner, I. and Eckert, C. and Henze, G. and Prada, J. and von Stackelberg, A. and Seeger, K. and Shalapour, S.
Clinical Cancer Research 19 (6): 1445-1457. 15 March 2013

Evaluation of combination therapy schedules of doxorubicin and an acid-sensitive albumin-binding prodrug of doxorubicin in the MIA PaCa-2 pancreatic xenograft model.
Kratz, F. and Azab, S. and Zeisig, R. and Fichtner, I. and Warnecke, A.
International Journal of Pharmaceutics 441 (1-2): 499-506. 30 January 2013

2012

In vitro and in vivo investigations into the carbene silver acetate anticancer drug candidate SBC1.
Fichtner, I. and Cinatl, J. and Michaelis, M. and Sanders, L.C. and Hilger, R. and Kennedy, B.N. and Reynolds, A.L. and Hackenberg, F. and Lally, G. and Quinn, S.J. and McRae, I. and Tacke, M.
Letters in Drug Design & Discovery 9 (9): 815-822. November 2012

Comparative evaluation of the biological properties of reducible and acid-sensitive folate prodrugs of a highly potent doxorubicin derivative.
Abu Ajaj, K. and El-Abadla, N. and Welker, P. and Azab, S. and Zeisig, R. and Fichtner, I. and Kratz, F.
European Journal of Cancer 48 (13): 2054-2065. September 2012

Systemic shRNA mediated knock down of S100A4 in colorectal cancer xenografted mice reduces metastasis formation.
Dahlmann, M. and Sack, U. and Herrmann, P. and Lemm, M. and Fichtner, I. and Schlag, P.M. and Stein, U.
Oncotarget 3 (8): 783-797. 7 August 2012

Combination therapy with the albumin-binding prodrug of doxorubicin (INNO-206) and doxorubicin achieves complete remissions and improves tolerability in an ovarian A2780 xenograft model.
Kratz, F. and Fichtner, I. and Graeser, R.
Investigational New Drugs 30 (4): 1743-1749. August 2012

Screening of well-established drugs targeting cancer metabolism: reproducibility of the efficacy of a highly effective drug combination in mice.
Abolhassani, M. and Guais, A. and Sanders, E. and Campion, F. and Fichtner, I. and Bonte, J. and Baronzio, G. and Fiorentini, G. and Israel, M. and Schwartz, L.
Investigational New Drugs 30 (4): 1331-1342. August 2012

In vitro and in vivo studies into the biological activities of 1,10-phenanthroline, 1,10-phenanthroline-5,6-dione and its copper(II) and silver(I) complexes.
McCann, M. and Santos, A.L.S. and da Silva, B.A. and Romanos, M.T.V. and Pyrrho, A.S. and Devereux, M. and Kavanagh, K. and Fichtner, I. and Kellett, A.
Toxicology Research 1 (1): 47-54. July 2012

Treatment of experimental brain metastasis with MTO-liposomes: impact of fluidity and LRP-targeting on the therapeutic result.
Orthmann, A. and Zeisig, R. and Suess, R. and Lorenz, D. and Lemm, M. and Fichtner, I.
Pharmaceutical Research 29 (7): 1949-1959. July 2012

High prevalence and breast cancer predisposing role of the BLMc.1642 C>T (Q548X) mutation in Russia.
Sokolenko, A.P. and Iyevleva, A.G. and Preobrazhenskaya, E.V. and Mitiushkina, N.V. and Abysheva, S.N. and Suspitsin, E.N. and Kuligina, E.S. and Gorodnova, T.V. and Pfeifer, W. and Togo, A.V. and Turkevich, E.A. and Ivantsov, A.O. and Voskresenskiy, D.V. and Dolmatov, G.D. and Bit-Sava, E.M. and Matsko, D.E. and Semiglazov, V.F. and Fichtner, I. and Larionov, A.A. and Kuznetsov, S.G. and Antoniou, A.C. and Imyanitov, E.N.
International Journal of Cancer 130 (12): 2867-2873. 15 June 2012

Novel Clostridium perfringens enterotoxin suicide gene therapy for selective treatment of claudin-3- and -4-overexpressing tumors.
Walther, W. and Petkov, S. and Kuvardina, O.N. and Aumann, J. and Kobelt, D. and Fichtner, I. and Lemm, M. and Piontek, J. and Blasig, I.E. and Stein, U. and Schlag, P.M.
Gene Therapy 19 (5): 494-503. May 2012

The inhibition of the integrin VLA-4 in MV3 melanoma cell binding by non-anticoagulant heparin derivatives.
Schlesinger, M. and Schmitz, P. and Zeisig, R. and Naggi, A. and Torri, G. and Casu, B. and Bendas, G.
Thrombosis Research 129 (5): 603-610. May 2012

Intrahepatic transplantation of CD34(+) cord blood stem cells into newborn and adult NOD/SCID mice induce differential organ engraftment.
Wulf-Goldenberg, A. and Keil, M. and Fichtner, I. and Eckert, K.
Tissue & Cell 44 (2): 80-86. April 2012

Transcriptional expression profile of cultured human embryonic stem cells in vitro and in vivo.
Keil, M. and Siegert, A. and Eckert, K. and Gerlach, J. and Haider, W. and Fichtner, I.
In Vitro Cellular & Developmental Biology Animal 48 (3): 165-174. March 2012

2011

S100A4-induced cell motility and metastasis is restricted by the Wnt/β-catenin pathway inhibitor calcimycin in colon cancer cells.
Sack, U. and Walther, W. and Scudiero, D. and Selby, M. and Aumann, J. and Lemos, C. and Fichtner, I. and Schlag, P.M. and Shoemaker, R.H. and Stein, U.
Molecular Biology of the Cell 22 (18): 3344-3354. September 2011

Novel effect of antihelminthic niclosamide on S100A4-mediated metastatic progression in colon cancer.
Sack, U. and Walther, W. and Scudiero, D. and Selby, M. and Kobelt, D. and Lemm, M. and Fichtner, I. and Schlag, P.M. and Shoemaker, R.H. and Stein, U.
Journal of the National Cancer Institute 103 (13): 1018-1036. 6 July 2011

Chemoresistance in non-small-cell lung cancer: can multidrug resistance markers predict the response of xenograft lung cancer models to chemotherapy?
Merk, J. and Rolff, J. and Dorn, C. and Leschber, G. and Fichtner, I.
European Journal of Cardio-Thoracic Surgery 40 (1): e29-e33. July 2011

Improving the transport of chemotherapeutic drugs across the blood-brain barrier.
Orthmann, A. and Fichtner, I. and Zeisig, R.
Expert Review of Clinical Pharmacology 4 (4): 477-490. July 2011

Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models.
Bergman, A.M. and Adema, A.D. and Balzarini, J. and Bruheim, S. and Fichtner, I. and Noordhuis, P. and Fodstad, O. and Myhren, F. and Sandvold, M.L. and Hendriks, H.R. and Peters, G.J.
Investigational New Drugs 29 (3): 456-466. June 2011

Development of resistance towards artesunate in MDA-MB-231 human breast cancer cells.
Bachmeier, B. and Fichtner, I. and Killian, P.H. and Kronski, E. and Pfeffer, U. and Efferth, T.
PLoS ONE 6 (5): e20550. 26 May 2011

Development of efficient acid cleavable multifunctional prodrugs derived from dendritic polyglycerol with a poly (ethylene glycol) shell.
Calderon, M. and Welker, P. and Licha, K. and Fichtner, I. and Graeser, R. and Haag, R. and Kratz, F.
Journal of Controlled Release 151 (3): 295-301. 10 May 2011

The antiangiogenic and antitumoral activity of titanocene Y* in vivo.
Fichtner, I. and Behrens, D. and Claffey, J. and Deally, A. and Gleeson, B. and Patil, S. and Weber, H. and Tacke, M.
Letters in Drug Design & Discovery 8 (4): 302-307. May 2011

Molecular mode of action and role of TP53 in the sensitivity to the novel epothilone sagopilone (ZK-EPO) in A549 non-small cell lung cancer cells.
Winsel, S. and Sommer, A. and Eschenbrenner, J. and Mittelstaedt, K. and Klar, U. and Hammer, S. and Hoffmann, J.
PLoS ONE 6 (4): e19273. 29 April 2011

Cellular pharmacology of multi- and duplex drugs consisting of ethynylcytidine and 5-fluoro-2'-deoxyuridine.
Bijnsdorp, I.V. and Schwendener, R.A. and Schott, H. and Fichtner, I. and Smid, K. and Laan, A.C. and Schott, S. and Losekoot, N. and Honeywell, R.J. and Peters, G.J.
Investigational New Drugs 29 (2): 248-257. April 2011

Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer.
Tan, W.L. and Bhattacharya, B. and Loh, M. and Balasubramanian, I. and Akram, M. and Dong, D. and Wong, L. and Thakkar, B. and Salto-Tellez, M. and Soo, R.A. and Fichtner, I. and Iacopetta, B. and Soong, R.
Cancer Biology & Therapy 11 (6): 599-608. 15 March 2011

Intervening in beta-catenin signaling by sulindac inhibits S100A4-dependent colon cancer metastasis.
Stein, U. and Arlt, F. and Smith, J. and Sack, U. and Herrmann, P. and Walther, W. and Lemm, M. and Fichtner, I. and Shoemaker, R.H. and Schlag, P.M.
Neoplasia 13 (2): 131-144. February 2011

Intrahepatically transplanted human cord blood cells reduce SW480 tumor growth in the presence of bispecific EpCAM/CD3 antibody.
Wulf-Goldenberg, A. and Eckert, K. and Fichtner, I.
Cytotherapy 13 (1): 108-113. January 2011

2010

Activation of the CMV-IE promoter by hyperthermia in vitro and in vivo: biphasic heat induction of cytosine deaminase suicide gene expression.
Kobelt, D. and Aumann, J. and Fichtner, I. and Stein, U. and Schlag, P.M. and Walther, W.
Molecular Biotechnology 46 (2): 197-205. October 2010

Interwoven four-compartment capillary membrane technology for three-dimensional perfusion with decentralized mass exchange to scale up embryonic stem cell culture.
Gerlach, J. and Luebberstedt, M. and Edsbagge, J. and Ring, A. and Hout, M. and Baun, M. and Rossberg, I. and Knoespel, F. and Peters, G. and Eckert, K. and Wulf-Goldenberg, A. and Bjoerquist, P. and Stachelscheid, H. and Urbaniak, T. and Schatten, G. and Miki, T. and Schmelzer, E. and Zeilinger, K.
Cells Tissues Organs 192 (1): 39-49. June 2010

Delivery of 5-azacytidine to human cancer cells by elaidic acid esterification increases therapeutic drug efficacy.
Brueckner, B. and Rius, M. and Rivera Markelova, M. and Fichtner, I. and Hals, P.A. and Sandvold, M.L. and Lyko, F.
Molecular Cancer Therapeutics 9 (5): 1256-1264. May 2010

Impact of membrane properties on uptake and transcytosis of colloidal nanocarriers across an epithelial cell barrier model.
Orthmann, A. and Zeisig, R. and Koklic, T. and Sentjurc, M. and Wiesner, B. and Lemm, M. and Fichtner, I.
Journal of Pharmaceutical Sciences 99 (5): 2423-2433. May 2010

Inhibition of pulmonary metastasis in a human MT3 breast cancer xenograft model by dual liposomes preventing intravasal fibrin clot formation.
Wenzel, J. and Zeisig, R. and Haider, W. and Habedank, S. and Fichtner, I.
Breast Cancer Research and Treatment 121 (1): 13-22. May 2010

Antitumor activity of vanadocene Y and its selenocyanate derivative in xenografted CAKI-1 tumors in mice.
Fichtner, I. and Claffey, J. and Deally, A. and Gleeson, B. and Hogan, M. and Rivera Markelova, M. and Mueller-Bunz, H. and Weber, H. and Tacke, M.
Journal of Organometallic Chemistry 695 (8): 1175-1181. 15 April 2010

Suspension medium influences interaction of mesenchymal stromal cells with endothelium and pulmonary toxicity after transplantation in mice.
Deak, E. and Ruester, B. and Keller, L. and Eckert, K. and Fichtner, I. and Seifried, E. and Henschler, R.
Cytotherapy 12 (2): 260-264. April 2010

Comparative profiling of the novel epothilone, sagopilone, in xenografts derived from primary non-small cell lung cancer.
Hammer, S. and Sommer, A. and Fichtner, I. and Becker, M. and Rolff, J. and Merk, J. and Klar, U. and Hoffmann, J.
Clinical Cancer Research 16 (5): 1452-1465. 1 March 2010

INNO-206, the (6-maleimidocaproyl hydrazone derivative of doxorubicin), shows superior antitumor efficacy compared to doxorubicin in different tumor xenograft models and in an orthotopic pancreas carcinoma model.
Graeser, R. and Esser, N. and Unger, H. and Fichtner, I. and Zhu, A. and Unger, C. and Kratz, F.
Investigational New Drugs 28 (1): 14-19. February 2010

Cell cycle effects of fatty acid derivatives of cytarabine, CP-4055, and of gemcitabine, CP-4126, as basis for the interaction with oxaliplatin and docetaxel.
Adema, A.D. and Laan, A.C. and Myhren, F. and Fichtner, I. and Verheul, H.M. and Sandvold, M.L. and Peters, G.J.
International Journal of Oncology 36 (1): 285-294. 1 January 2010

Comparison of the effect of orally administered soluble β-(1-3),(1-6)-D-glucan and of G-CSF on the recovery of murine hematopoiesis.
Harnack, U. and Eckert, K. and Fichtner, I. and Pecher, G.
In Vivo 24 (1): 59-63. January 2010

Inhibition of metastasis in a murine 4T1 breast cancer model by liposomes preventing tumor cell-platelet interactions.
Wenzel, J. and Zeisig, R. and Fichtner, I.
Clinical and Experimental Metastasis 27 (1): 25-34. January 2010

2009

Efficacy of MS-275, a selective inhibitor of class I histone deacetylases, in human colon cancer models.
Bracker, T.U. and Sommer, A. and Fichtner, I. and Faus, H. and Haendler, B. and Hess-Stumpp, H.
International Journal of Oncology 35 (4): 909-920. October 2009

Oral administration of a soluble 1-3, 1-6 beta-glucan during prophylactic survivin peptide vaccination diminishes growth of a B cell lymphoma in mice.
Harnack, U. and Eckert, K. and Fichtner, I. and Pecher, G.
International Immunopharmacology 9 (11): 1298-1303. October 2009

Patient-derived xenografts of non-small-cell lung cancer: a pre-clinical model to evaluate adjuvant chemotherapy?
Merk, J. and Rolff, J. and Becker, M. and Leschber, G. and Fichtner, I.
European Journal of Cardio-Thoracic Surgery 36 (3): 454-459. September 2009

A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential.
Fritzmann, J. and Morkel, M. and Besser, D. and Budczies, J. and Kosel, F. and Brembeck, F.H. and Stein, U. and Fichtner, I. and Schlag, P.M. and Birchmeier, W.
Gastroenterology 137 (11): 165-175. July 2009

In vitro and in vivo study of an albumin-binding prodrug of doxorubicin that is cleaved by cathepsin B.
Abu Ajaj, K. and Graeser, R. and Fichtner, I. and Kratz, F.
Cancer Chemotherapy and Pharmacology 64 (2): 413-418. July 2009

Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo.
Heringer-Walther, S. and Eckert, K. and Schumacher, S.M. and Uharek, L. and Wulf-Goldenberg, A. and Gembardt, F. and Fichtner, I. and Schultheiss, H.P. and Rodgers, K. and Walther, T.
Haematologica 94 (6): 857-860. June 2009

Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases.
Hoffmann, J. and Fichtner, I. and Lemm, M. and Lienau, P. and Hess-Stumpp, H. and Rotgeri, A. and Hofmann, B. and Klar, U.
Neuro Oncology 11 (2): 158-166. April 2009

Inhibition of breast cancer metastasis by dual liposomes to disturb complex formation.
Wenzel, J. and Zeisig, R. and Fichtner, I.
International Journal of Pharmaceutics 370 (1-2): 121-128. 31 March 2009

Radiosensitisation of U87MG brain tumours by anti-epidermal growth factor receptor monoclonal antibodies.
Diaz Miqueli, A. and Rolff, J. and Lemm, M. and Fichtner, I. and Perez, R. and Montero, E.
British Journal of Cancer 100 (6): 950-958. 24 March 2009

MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis.
Stein, U. and Walther, W. and Arlt, F. and Schwabe, H. and Smith, J. and Fichtner, I. and Birchmeier, W. and Schlag, P.M.
Nature Medicine 15 (1): 59-67. January 2009

Anti-proliferative efficacy of icariin on HepG2 hepatoma and its possible mechanism of action.
Yang, J.X. and Fichtner, I. and Becker, M. and Lemm, M. and Wang, X.M.
American Journal of Chinese Medicine 37 (6): 1153-1165. 2009

Nonviral jet-injection technology for intratumoral in vivo gene transfer of naked DNA.
Walther, W. and Fichtner, I. and Schlag, P.M. and Stein, U.S.
Methods in Molecular Biology 542 : 195-208. 2009

Response of patient-derived non-small cell lung cancer xenografts to classical and targeted therapies is not related to multidrug resistance markers.
Rolff, J. and Dorn, C. and Merk, J. and Fichtner, I.
Journal of Oncology 2009 : 814140. 2009

2008

Antitumor activity of oxali-titanocene Y in xenografted CAKI-1 tumors in mice.
Fichtner, I. and Behrens, D. and Claffey, J. and Gleeson, B. and Hogan, M. and Wallis, D. and Weber, H. and Tacke, M.
Letters in Drug Design & Discovery 5 (8): 489-493. December 2008

Interaction of alkylphospholipid liposomes with MT-3 breast-cancer cells depends critically on cholesterol concentration.
Koklic, T. and Zeisig, R. and Sentjurc, M.
Biochimica et Biophysica Acta - Biomembranes 1778 (12): 2682-2689. December 2008

Establishment of patient-derived non-small cell lung cancer xenografts as models for the identification of predictive biomarkers.
Fichtner, I. and Rolff, J. and Soong, R. and Hoffmann, J. and Hammer, S. and Sommer, A. and Becker, M. and Merk, J.
Clinical Cancer Research 14 (20): 6456-6468. 15 October 2008

In vitro activity and mechanism of action of a duplex and multidrug of ethynylcytidine and 5-fluorodeoxyuridine.
Bijnsdorp, I. and Schwendener, R. and Schott, H. and Schott, S. and Fichtner, I. and Honeywell, R. and Losekoot, N. and Laan, A. and Peters, G.J.
Nucleic Acids Symposium Series 52 : 651. 8 September 2008

In vitro and in vivo evaluation of doxorubicin conjugates with the divalent peptide E-[c(RGDfK)2] that targets integrin alphavbeta3.
Ryppa, C. and Mann-Steinberg, H. and Fichtner, I. and Weber, H. and Satchi-Fainaro, R. and Biniossek, M.L. and Kratz, F.
Bioconjugate Chemistry 19 (7): 1414-1422. July 2008

Tissue factor expression pattern in human non-small cell lung cancer tissues indicate increased blood thrombogenicity and tumor metastasis.
Goldin-Lang, P. and Tran, Q.V. and Fichtner, I. and Eisenreich, A. and Antoniak, S. and Schulze, K. and Coupland, S.E. and Poller, W. and Schultheiss, H.P. and Rauch, U.
Oncology Reports 20 (1): 123-128. July 2008

Praeklinische Daten als Grundlage fuer die Konzeption klinischer Studien [Preclinical data as basis for the design of clinical studies].
Fichtner, I.
Onkologie 31 (Suppl. 2): 34-38. May 2008

Antitumor activity of Titanocene Y in xenografted PC3 tumors in mice.
Dowling, C.M. and Claffey, J. and Cuffe, S. and Fichtner, I. and Pampillon, C. and Sweeney, N.J. and Strohfeldt, K. and Watson, R.W. and Tacke, M.
Letters in Drug Design & Discovery 5 (2): 141-144. March 2008

Cytokine-pretreatment of CD34(+) cord blood stem cells in vitro reduces long-term cell engraftment in NOD/SCID mice.
Wulf-Goldenberg, A. and Eckert, K. and Fichtner, I.
European Journal of Cell Biology 87 (2): 69-80. 14 February 2008

Complete in vivo reversal of the multidrug resistance phenotype by jet-injection of anti-MDR1 short hairpin RNA-encoding plasmid DNA.
Stein, U. and Walther, W. and Stege, A. and Kaszubiak, A. and Fichtner, I. and Lage, H.
Molecular Therapy 16 (1): 178-186. January 2008

2007

In vivo and in vitro activity and mechanism of action of the multidrug cytarabine-L-glycerylyl-fluorodeoxyuridine.
Bijnsdorp, I.V. and Schwendener, R.A. and Schott, H. and Fichtner, I. and Smid, K. and Schott, S. and Laan, A.C. and Peters, G.J.
Nucleosides Nucleotides & Nucleic Acids 26 (10-12): 1619-1624. 5 December 2007

Substituted titanocenes induce caspase-dependent apoptosis in human epidermoid carcinoma cells in vitro and exhibit antitumour activity in vivo.
Bannon, J.H. and Fichtner, I. and O'Neill, A. and Pampillon, C. and Sweeney, N.J. and Strohfeldt, K. and Watson, R.W. and Tacke, M. and McGee, M.M.
British Journal of Cancer 97 (9): 1234-1241. 5 November 2007

Development of albumin-binding camptothecin prodrugs using a peptide positional scanning library.
Schmid, B. and Warnecke, A. and Fichtner, I. and Jung, M. and Kratz, F.
Bioconjugate Chemistry 18 (6): 1786-1799. November 2007

Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT.
Yde, C.W. and Frogne, T. and Lykkesfeldt, A.E. and Fichtner, I. and Issinger, O.G. and Stenvang, J.
Cancer Letters 256 (2): 229-237. 28 October 2007

Enhanced tumorigenicity of fibroblasts transformed with human herpesvirus 8 chemokine receptor vGPCR by successive passage in nude and immunocompetent mice.
Thirunarayanan, N. and Cifire, F. and Fichtner, I. and Posner, S. and Benga, J. and Reiterer, P. and Kremmer, E. and Koelble, K. and Lipp, M.
Oncogene 26 (39): 5702-5712. 23 August 2007

Loss of tumourigenicity of stably ERbeta-transfected MCF-7 breast cancer cells.
Behrens, D. and Gill, J.H. and Fichtner, I.
Molecular and Cellular Endocrinology 274 (1-2): 19-29. 15 August 2007

Synthesis, cleavage profile, and antitumor efficacy of an albumin-binding prodrug of methotrexate that is cleaved by plasmin and cathepsin B.
Warnecke, A. and Fichtner, I. and Sass, G. and Kratz, F.
Archiv der Pharmazie 340 (8): 389-395. August 2007

The mTOR pathway inhibitor RAD001 (everolimus) is highly efficacious in tamoxifen-sensitive and -resistant breast cancer xenografts.
Behrens, D. and Lykkesfeldt, A.E. and Fichtner, I.
Targeted Oncology 2 (3): 135-144. July 2007

Albumin-Binding Prodrugs of Camptothecin and Doxorubicin with an Ala-Leu-Ala-Leu-Linker That Are Cleaved by Cathepsin B: Synthesis and Antitumor Efficacy.
Schmid, B. and Chung, D.E. and Warnecke, A. and Fichtner, I. and Kratz, F.
Bioconjugate Chemistry 18 (3): 702-716. May 2007

Poly(ethylene oxide)-block-poly(glutamic acid) coated maghemite nanoparticles: in vitro characterization and in vivo behaviour.
Kaufner, L. and Cartier, R. and Wuestneck, R. and Fichtner, I. and Pietschmann, S. and Bruhn, H. and Schuett, D. and Thuenemann, A.F. and Pison, U.
Nanotechnology 18 (11): 115710. 21 March 2007

Increase in fluidity in the membrane of MT3 breast cancer cells correlates with enhanced cell adhesion in vitro and increased lung metastasis in NOD/SCID mice.
Zeisig, R. and Koklic, T. and Wiesner, B. and Fichtner, I. and Sentjurc, M.
Archives of Biochemistry and Biophysics 459 (1): 98-106. 1 March 2007

Heat-inducible in vivo gene therapy of colon carcinoma by human mdr1 promoter-regulated tumor necrosis factor-alpha expression.
Walther, W. and Arlt, F. and Fichtner, I. and Aumann, J. and Stein, U. and Schlag, P.M.
Molecular Cancer Therapeutics 6 (1): 236-243. January 2007

2006

The thalidomide analogue, CC-4047, induces apoptosis signaling and growth arrest in childhood acute lymphoblastic leukemia cells in vitro and in vivo.
Shalapour, S. and Zelmer, A. and Pfau, M. and Moderegger, E. and Costa-Blechschmidt, C. and van Landeghem, F.K. and Taube, T. and Fichtner, I. and Buehrer, C. and Henze, G. and Seeger, K. and Wellmann, S.
Clinical Cancer Research 12 (18): 5526-5532. 15 September 2006

Antitumor activity of a dual cytokine/single-chain antibody fusion protein for simultaneous delivery of GM-CSF and IL-2 to Ep-CAM expressing tumor cells.
Schanzer, J.M. and Fichtner, I. and Baeuerle, P.A. and Kufer, P.
Journal of Immunotherapy 29 (5): 477-488. September 2006

Histone deacetylase inhibitors have antitumor activity in two NOD/SCID mouse models of B-cell precursor childhood acute lymphoblastic leukemia.
Einsiedel, H.G. and Kawan, L. and Eckert, C. and Witt, O. and Fichtner, I. and Henze, G. and Seeger, K.
Leukemia 20 (8): 1435-1436. August 2006

Potent inhibition of local and disseminated tumor growth in immunocompetent mouse models by a bispecific antibody construct specific for Murine CD3.
Schlereth, B. and Kleindienst, P. and Fichtner, I. and Lorenczewski, G. and Brischwein, K. and Lippold, S. and Silva, A.D. and Locher, M. and Kischel, R. and Lutterbuese, R. and Kufer, P. and Baeuerle, P.A.
Cancer Immunology Immunotherapy 55 : 785-796. July 2006

Uptake, biodistribution, and time course of naked plasmid DNA trafficking after intratumoral in vivo jet injection.
Walther, W. and Minow, T. and Martin, R. and Fichtner, I. and Schlag, P.M. and Stein, U.
Human Gene Therapy 17 (6): 611-624. 15 June 2006

Anti-tumor activity of Titanocene Y in xenografted Caki-1 tumors in mice.
Fichtner, I. and Pampillon, C. and Sweeney, N.J. and Strohfeldt, K. and Tacke, M.
Anti-Cancer Drugs 17 (3): 333-336. March 2006

MT110: A novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors.
Brischwein, K. and Schlereth, B. and Guller, B. and Steiger, C. and Wolf, A. and Lutterbuese, R. and Offner, S. and Locher, M. and Urbig, T. and Raum, T. and Kleindienst, P. and Wimberger, P. and Kimmig, R. and Fichtner, I. and Kufer, P. and Hofmeister, R. and da Silva, A.J. and Baeuerle, P.A.
Molecular Immunology 43 (8): 1129-1143. March 2006

Anti-cancer effects of bortezomib against chemoresistant neuroblastoma cell lines in vitro and in vivo.
Michaelis, M. and Fichtner, I. and Behrens, D. and Haider, W. and Rothweiler, F. and Mack, A. and Cinatl, J. and Doerr, H.W. and Cinatl, J.
International Journal of Oncology 28 (2): 439-446. February 2006

Proteomics of xenografted human breast cancer indicates novel targets related to tamoxifen resistance.
Besada, V. and Diaz, M. and Becker, M. and Ramos, Y. and Castellanos-Serra, L. and Fichtner, I.
Proteomics 6 (3): 1038-1048. February 2006

2005

Membrane switch hypothesis. 1. Cell density influences lateral domain structure of tumor cell membranes.
Koklic, T. and Pirs, M. and Zeisig, R. and Abramovic, Z. and Sentjurc, M.
Journal of Chemical Information and Modeling 45 (6): 1701-1707. 28 November 2005

Development of albumin-binding doxorubicin prodrugs that are cleaved by prostate-specific antigen.
Kratz, F. and Mansour, A. and Soltau, J. and Warnecke, A. and Fichtner, I. and Unger, C. and Drevs, J.
Archiv der Pharmazie 338 : 462-472. 7 October 2005

Synthesis and biological evaluation of spin-labeled alkylphospholipid analogs.
Mravljak, J. and Zeisig, R. and Pecar, S.
Journal of Medicinal Chemistry 48 (20): 6393-6399. 6 October 2005

Nonviral jet-injection gene transfer for efficient in vivo cytosine deaminase suicide gene therapy of colon carcinoma.
Walther, W. and Stein, U. and Fichtner, I. and Kobelt, D. and Aumann, J. and Arlt, F. and Schlag, P.M.
Molecular Therapy 12 (6): 1176-1184. 29 September 2005

Human cord blood stem cells generate human cytokeratin 18-negative hepatocyte-like cells in injured mouse liver.
Sharma, A.D. and Cantz, T. and Richter, R. and Eckert, K. and Henschler, R. and Wilkens, L. and Jochheim-Richter, A. and Arseniev, L. and Ott, M.
American Journal of Pathology 167 (2): 555-564. 1 August 2005

Effect of surface modified liposomes on the aggregation of platelets and tumor cells.
Keil, C. and Zeisig, R. and Fichtner, I.
Thrombosis and Haemostasis 94 (2): 404-411. August 2005

The alpha4beta1 and alpha5beta1 integrins mediate engraftment of granulocyte-colony-stimulating factor-mobilized human hematopoietic progenitor cells.
Carstanjen, D. and Gross, A. and Kosova, N. and Fichtner, I. and Salama, A.
Transfusion 45 : 1192-1200. 1 July 2005

Quinols as novel therapeutic agents. 2.(1) 4-(1-arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents.
Berry, J.M. and Bradshaw, T.D. and Fichtner, I. and Ren, R. and Schwalbe, C.H. and Wells, G. and Chew, E.H. and Stevens, M.F. and Westwell, A.D.
Journal of Medicinal Chemistry 48 : 639-644. 27 January 2005

Distinct gene expression patterns in a tamoxifen-sensitive human mammary carcinoma xenograft and its tamoxifen-resistant subline MaCa 3366/TAM.
Becker, M. and Sommer, A. and Kraetzschmar, J.R. and Seidel, H. and Pohlenz, H.D. and Fichtner, I.
Molecular Cancer Therapeutics 4 : 151-170. 1 January 2005

Eradication of tumors from a human colon cancer cell line and from ovarian cancer metastases in immunodeficient mice by a single-chain Ep-CAM-/CD3-bispecific antibody construct.
Schlereth, B. and Fichtner, I. and Lorenczewski, G. and Kleindienst, P. and Brischwein, K. and da Silva, A. and Kufer, P. and Lutterbuese, R. and Junghahn, I. and Kasimir-Bauer, S. and Wimberger, P. and Kimmig, R. and Baeuerle, P.A.
Cancer Research 65 : 2882-2889. 1 January 2005

Transplantation of human acute myeloid leukemia (AML) cells in immunodeficient mice reveals altered cell surface phenotypes and expression of human endothelial markers.
Henschler, R. and Goettig, S. and Junghahn, I. and Bug, G. and Seifried, E. and Mueller, A.M. and Fichtner, I.
Leukemia Research 29 (10): 1191-1199. 1 January 2005

Use of the nuclease inhibitor aurintricarboxylic acid (ATA) for improved non-viral intratumoral in vivo gene transfer by jet-injection.
Walther, W. and Stein, U. and Siegel, R. and Fichtner, I. and Schlag, P.M.
Journal of Gene Medicine 7 (4): 477-485. 1 January 2005

2004

Synthesis and biological activity of water-soluble maleimide derivatives of the anticancer drug Carboplatin designed as albumin-binding prodrugs.
Warnecke, A. and Fichtner, I. and Garmann, D. and Jaehde, U. and Kratz, F.
Bioconjugate Chemistry 15 (6): 1349-1359. 1 November 2004

Differential protein expression pattern in tamoxifen-sensitive and -resistant breast cancer xenografts.
Fichtner, I. and Becker, M. and Besada, V. and Castellanos-Serra, L.
International Journal of Clinical Pharmacology and Therapeutics 42 (11): 632-634. November 2004

The experimental antitumor agents phortress and doxorubicin are equiactive against human-derived breast carcinoma xenograft models.
Fichtner, I. and Monks, A. and Hose, C. and Stevens, M.F. and Bradshaw, T.D.
Breast Cancer Research and Treatment 87 (1): 97-107. 1 September 2004

Reduction of tamoxifen resistance in human breast carcinomas by tamoxifen-containing liposomes in vivo.
Zeisig, R. and Rueckerl, D. and Fichtner, I.
Anti-Cancer Drugs 15 (7): 707-714. 1 August 2004

In vivo models for endocrine-dependent breast carcinomas: special considerations of clinical relevance.
Fichtner, I. and Becker, M. and Zeisig, R. and Sommer, A.
European Journal of Cancer 40 (6): 845-851. April 2004

Antitumor activity of imidazothioxanthones in murine and human tumor models in vitro and in vivo.
Varvaresou, A. and Iakovou, K. and Gikas, E. and Fichtner, I. and Fiebig, H.H. and Kelland, L.R. and Double, J.A. and Bibby, M.C. and Hendriks, H.R.
Anticancer Research 24 (2): 907-919. March 2004

Effect of sialyl Lewis X-glycoliposomes on the inhibition of E-selectin-mediated tumour cell adhesion in vitro.
Zeisig, R. and Stahn, R. and Wenzel, K. and Behrens, D. and Fichtner, I.
Biochimica et Biophysica Acta - Biomembranes 1660 (1): 31-40. 28 January 2004

Verfahren zur Diagnose und Therapie von antioestrogentherapieresistenten Brusttumoren [Diagnosis and therapy of breast tumours resistant to antiestrogen treatment].
Fichtner, I. and Becker, M. and Besada-Perez, V. and Castellanos-Serra, L.
DE10310198A1 ; WO0408137. 22 January 2004

Liposomal 4-hydroxy-tamoxifen: effect on cellular uptake and resulting cytotoxicity in drug resistant breast cancer cells in vitro.
Zeisig, R. and Teppke, A.D. and Behrens, D. and Fichtner, I.
Breast Cancer Research and Treatment 87 (3): 245-254. 1 January 2004

Low-volume jet injection for efficient nonviral in vivo gene transfer.
Walther, W. and Stein, U. and Fichtner, I. and Schlag, P.M.
Molecular Biotechnology 28 (2): 121-128. 1 January 2004

Anticancer drug response and expression of molecular markers in early-passage xenotransplanted colon carcinomas.
Fichtner, I. and Slisow, W. and Gill, J. and Becker, M. and Elbe, B. and Hillebrand, T. and Bibby, M.
European Journal of Cancer 40 (2): 298-307. January 2004

2003

Animal experiments - An essential component for the development of liposomal anticancer agents.
Fichtner, I. and Reszka, R. and Arndt, D. and Zeisig, R.
Journal of Liposome Research 13 (1): 9-15. 3 December 2003

A new approach for the treatment of malignant melanoma: Enhanced antitumor efficacy of an albumin-binding doxorubicin prodrug that is cleaved by matrix metalloproteinase 2.
Mansour, A.M. and Drevs, J. and Esser, N. and Hamada, F.M. and Badary, O.A. and Unger, C. and Fichtner, I. and Kratz, F.
Cancer Research 63 (14): 4062-4066. 15 July 2003

CS-1, a novel c-kithi+ acute myeloid leukemia cell line with dendritic cell differentiation capacity and absent immunogenicity.
Erben, U. and Thiel, E. and Bittroff-Leben, A. and Schoch, C. and Fichtner, I. and Durkop, H. and Notter, M.
International Journal of Cancer 105 (2): 232-240. 10 June 2003

Isolierung von Neuronen und Stammzellen fuer Nervenfasern aus einer Probe [Isolation of neurones and stem cells for nerve fibres from a sample].
Pfrieger, F.W. and Naegler, K.
EP1448764 ; WO0342374. 22 May 2003

Oral verabreichbare pharmazeutische Zubereitung umfassend liposomal verkapseltes Taxol [Orally administered pharmaceutical preparation comprising liposomically encapsulated paclitaxel].
Reszka, R. and Fichtner, I.
DE10154464A1 ; DE10154464B4 ; EP1443904 ; WO0339437. 22 May 2003

Chemo- and radiation sensitivity of xenografted acute lymphoblastic leukemias-correlation to the expression of multidrug resistance proteins.
Fichtner, I. and Paal, K. and Borgmann, A. and Badiali, L. and Wurm, R. and Henze, G.
Anticancer Research 23 (3): 2657-2664. May 2003

T cell costimulus-independent and very efficacious inhibition of tumor growth in mice bearing subcutaneous or leukemic human B cell lymphoma xenografts by a CD19-/CD3-bispecific single-chain antibody construct1.
Dreier, T. and Baeuerle, P.A. and Fichtner, I. and Gruen, M. and Schlereth, B. and Lorenczewski, G. and Kufer, P. and Lutterbuese, R. and Riethmueller, G. and Gjorstrup, P. and Bargou, R.C.
Journal of Immunology 170 (8): 4397-4402. 15 April 2003

Antileukaemic activity of treosulfan in xenografted human acute lymphoblastic leukaemias (ALL).
Fichtner, I. and Becker, M. and Baumgart, J.
European Journal of Cancer 39 (6): 801-807. April 2003

Lipoplexes with alkylphospholipid as new helper lipid for efficient in vitro and in vivo gene transfer in tumor therapy.
Zeisig, R. and Ress, A. and Fichtner, I. and Walther, W.
Cancer Gene Therapy 10 (4): 302-311. April 2003

Interleukin-3 promotes proliferation and differentiation of human hematopoietic stem cells but reduces their repopulation potential in NOD/SCID mice.
Nitsche, A. and Junghahn, I. and Thulke, S. and Aumann, J. and Radonic, A. and Fichtner, I. and Siegert, W.
Stem Cells 21 (2): 236-244. March 2003

2002

Probing the cysteine-34 position of endogenous serum albumin with thiol-binding doxorubicin derivatives. Improved efficacy of an acid-sensitive doxorubicin derivative with specific albumin-binding properties compared to that of the parent compound.
Kratz, F. and Warnecke, A. and Scheuermann, K. and Stockmar, C. and Schwab, J. and Lazar, P. and Drueckes, P. and Esser, N. and Drevs, J. and Rognan, D. and Bissantz, C. and Hinderling, C. and Folkers, G. and Fichtner, I. and Unger, C.
Journal of Medicinal Chemistry 45 (25): 5523-5533. 5 December 2002

Sensitive PCR method for the detection and real-time quantification of human cells in xenotransplantation systems.
Becker, M. and Nitsche, A. and Neumann, C. and Aumann, J. and Junghahn, I. and Fichtner, I.
British Journal of Cancer 87 (11): 1328-1335. 18 November 2002

The influence of cholesterol and charge on the membrane domains of alkylphospholipid liposomes as studied by EPR.
Koklic, T. and Sentjurc, M. and Zeisig, R.
Journal of Liposome Research 12 (4): 335-352. November 2002

Verwendung von Nucleosiden, Nucleobasen und deren Derivaten zur verbesserten Gewinnung von adulten Stammzellen [Use of nucleosides, nucleobases and derivatives thereof for improved production of adult stem cells].
Langen, P. and Fichtner, I.
DE10117615A1 ; WO0281664. 10 October 2002

In vitro and in vivo activity of MT201, a fully human monoclonal antibody for pancarcinoma treatment.
Naundorf, S. and Preithner, S. and Mayer, P. and Lippold, S. and Wolf, A. and Hanakam, F. and Fichtner, I. and Kufer, P. and Raum, T. and Riethmueller, G. and Baeuerle, P.A. and Dreier, T.
International Journal of Cancer 100 (1): 101-110. 1 July 2002

Intratumoral low-volume jet-injection for efficient nonviral gene transfer.
Walther, W. and Stein, U. and Fichtner, I. and Voss, C. and Schmidt, T. and Schleef, M. and Nellessen, T. and Schlag, P.M.
Molecular Biotechnology 21 (2): 105-115. 1 June 2002

Verwendung von Schwangerschaftsproteinen, Liposomen, nativen Muzin-Fragmenten und Mimikry-Verbindungen zur Behandlung und Prophylaxe von entzuendlichen Erkrankungen, zur Verhinderung der Metastasierung und zur Prophylaxe von Tumorerkrankungen.
Stahn, R. and Goletz, S. and Jeschke, U. and Fichtner, I. and Zeisig, R.
DE10056136A1. 16 May 2002

The EORTC laboratory research division.
Brunner, N. and Double, J. and Fichtner, I. and Gescher, A. and Newell, D. and Oosterhuis, W. and Price, P.
European Journal of Cancer 38 (4): S14-S18. March 2002

Preclinical evaluation of amino acid prodrugs of novel antitumor 2-(4-amino-3-methylphenyl)benzothiazoles.
Bradshaw, T.D. and Bibby, M.C. and Double, J.A. and Fichtner, I. and Cooper, P.A. and Alley, M.C. and Donohue, S. and Stinson, S.F. and Tomaszewjski, J.E. and Sausville, E.A. and Stevens, M.F.G.
Molecular Cancer Therapeutics 1 (4): 239-246. 1 February 2002

Human hematopoiesis in murine embryos after injecting human cord blood-derived hematopoietic stem cells into murine blastocysts.
Harder, F. and Henschler, R. and Junghahn, I. and Lamers, M.C. and Mueller, A.M.
Blood 99 (2): 719-721. 15 January 2002

Inhibition of carbohydrate mediated cell adhesion by liposomes as a possible way to prevent tumour metastasis.
Zeisig, R. and Stahn, R. and Fichtner, I.
Cellular and Molecular Biology Letters 7 (2): 270-271. 2002

2001

Mittel zur Tumortherapie auf Liposomenbasis, die Tamoxifen enthalten [Agents provided for treating tumors, based on liposomes, and containing tamoxifen].
Zeisig, R. and Fichtner, I. and Arndt, D.
EP1135193. 31 October 2001

Altered neutrophil homeostasis in kinin B1 receptor deficient mice.
Araújo, R.C. and Kettritz, R. and Fichtner, I. and Paiva, A.C.M. and Pesquero, J.B. and Bader, M.
Biological Chemistry 382 : 91-95. 1 January 2001

Analysis of mouse beta-haptoglobin chain by lectin affinoblotting detection.
Roemer, I. and Vogel, T. and Otto, A. and Fichtner, I. and Klose, J.
Electrophoresis 22 : 3038-3042. 1 January 2001

Cancerostatic octadecylpiperidinoylphosphate liposomes: effect of composition on uptake by and toxicity to J774 mouse macrophage cells and MT1 breast cancer cells in vitro.
Zeisig, R. and Stahn, R. and Teppke, A.D. and Arndt, D.
Anti-Cancer Drug Design 16 (1): 19-26. 1 January 2001

Early macrophage and cytokine response during the growth of immunogenic and non-immunogenic murine tumors.
Kisseleva, E. and Becker, M. and Lemm, M. and Fichtner, I.
Anticancer Research 21 (5): 3477-3484. 1 January 2001

Generation of an immortalized human CD4+ T cell clone inhibiting tumor growth in mice.
Pecher, G. and Harnack, U. and Guenther, M. and Hummel, M. and Fichtner, I. and Schenk, J.A.
Biochemical and Biophysical Research Communications 283 (4): 738-742. 1 January 2001

In vivo Gentransfer nackter DNA in xenotransplantierte Kolonkarzinome in der Nude Maus mit Hilfe der Jet-Injektion [In vivo gene transfer of naked DNA into xenotransplanted colon carcinoma by jet-injection].
Walther, W. and Stein, U. and Fichtner, I. and Schlag, P.M.
Chirurgisches Forum 30 : 69-72. 1 January 2001

Influence of surface-modifying surfactants on the pharmacokinetic behavior of 14C-poly (methylmethacrylate) nanoparticles in experimental tumor models.
Lode, J. and Fichtner, I. and Kreuter, J. and Berndt, A. and Diederichs, J.E. and Reszka, R.
Pharmaceutical Research 18 (11): 1613-1619. 1 January 2001

Liposomal bleomycin: increased therapeutic activity and decreased pulmonary toxicity in mice.
Arndt, D. and Zeisig, R. and Bechtel, D. and Fichtner, I.
Drug Delivery 8 : 1-7. 1 January 2001

Liposomes in the food industry.
Zeisig, R. and Caemmerer, B.
In: Mircoencapsulation of Food Ingredients. Leatherhead Publishing, Surrey, 101-119. 1 January 2001

Nonviral in vivo gene delivery into tumors using a novel low volume jet-injection technology.
Walther, W. and Stein, U. and Fichtner, I. and Malcherek, L. and Lemm, M. and Schlag, P.M.
Gene Therapy 8 (3): 173-180. 1 January 2001

Preclinical and clinical aspects on the use of amifostine as chemoprotectorin neuroblastoma patients.
Fulda, S. and Fichtner, I. and Hero, B. and Berthold, F.
Medical and Pediatric Oncology 36 : 199-202. 1 January 2001

Quantification of human cells in NOD/SCID mice by duplex real-time polymerase reaction.
Nitsche, A. and Becker, M. and Junghahn, I. and Aumann, J. and Landt, O. and Fichtner, I. and Wittig, B. and Siegert, W.
Haematologica 86 : 693-699. 1 January 2001

Sialyl Lewisx-liposomes as vehicles for site-directed, E-selectin-mediated drug transfer into activated endothelial cells.
Stahn, R. and Grittner, C. and Zeisig, R. and Karsten, U. and Felix, S.B. and Wenzel, K.
Cellular and Molecular Life Sciences 58 (1): 141-147. 1 January 2001

The composition-dependent presence of free (micellar) alkylphospholipid in liposomal formulations of octadecyl-1,1-dimethyl-piperidino-4-yl-phosphate affects its cytotoxic activity in vitro.
Zeisig, R. and Mueller, K. and Maurer, N. and Arndt, D. and Fahr, A.
Journal of Membrane Biology 182 (1): 61-69. 1 January 2001

2000

Childhood all blasts retain phenotypic and genotypic characteristics upon long-term serial passage in NOD/SCID mice.
Borgmann, A. and Baldy, C. and von Stackelberg, A. and Beyermann, B. and Fichtner, I. and Nuernberg, P. and Henze, G.
Pediatric Hematology and Oncology 17 (8): 635-650. 1 December 2000

Donor stromal cells from human blood engraft in NOD/SCID mice.
Goan, S.R. and Junghahn, I. and Wissler, M. and Becker, M. and Aumann, J. and Just, U. and Martiny-Baron, G. and Fichtner, I. and Henschler, R.
Blood 96 : 3971-3978. 1 December 2000

Phospholipid- and fatty acid-composition in the erythrocyte membrane of the one-humped camel [Camelus dromedarius] and its influence on vesicle properties prepared from these lipids.
Warda, M. and Zeisig, R.
Deutsche Tieraerztliche Wochenschrift 107 (9): 368-373. 1 September 2000

Mittel zum nichtviralen Transfer von DNS in eukaryotische Zellen.
Zeisig, R. and Walther, W.
DE19959690A1. 8 June 2000

Mittel zur Tumortherapie.
Zeisig, R. and Fichtner, I. and Arndt, D.
DE19959689A1. 8 June 2000

Development and characterization of a tamoxifen resistant breast carcinoma xenograft.
Naundorf, H. and Becker, M. and Lykkesfeldt, A.E. and Elbe, B. and Neumann, C. and Buttner, B. and Fichtner, I.
British Journal of Cancer 82 (11): 1844-1850. 1 June 2000

mdr1 promoter-driven tumor necrosis factor-alpha expression for a chemotherapy-controllable combined in vivo gene therapy and chemotherapy of tumors.
Walther, W. and Stein, U. and Fichtner, I. and Alexander, M. and Shoemaker, R.H. and Schlag, P.M.
Cancer Gene Therapy 7 (6): 893-900. 1 June 2000

Cell adhesion inhibition by glycoliposomes: Effects of vesicle diameter and ligand density.
Stahn, R. and Zeisig, R.
Tumor Biology 21 (3): 176-186. 1 May 2000

Verwendung von Nucleosiden, Nucleobasen und deren Derivaten zum Herabsetzen thrombocytopenischer Nebenwirkungen von Cytostatika.
Fichtner, I. and Langen, P.
DE19842578A1 ; EP1037618. 23 March 2000

Differences in immunoreactivity of estrogen receptor (ER) in tamoxifen-sensitive and -resistant breast carcinomas: preclinical and first clinical investigations.
Naundorf, H. and Jost-Reuhl, B. and Becker, M. and Reuhl, T. and Neumann, C. and Fichtner, I.
Breast Cancer Research and Treatment 60 (1): 81-92. 1 March 2000

Cytotoxicity, cell-cycle perturbations and apoptosis in human tumor cells by lipophilic N4-alkyl-1-beta-D-arabinofuranosylcytosine derivatives and the new heteronucleoside phosphate dimer arabinocytidylyl-(5' -> 5')-N4-octadecyl-1-beta-d-arabinofuranosylcytosine.
Horber, D.H. and Cattaneo-Pangrazzi, R.M.C. and von Ballmoos, P. and Schott, H. and Ludwig, P.S. and Eriksson, S. and Fichtner, I. and Schwendener, R.A.
Journal of Cancer Research and Clinical Oncology 126 (6): 311-319. 1 January 2000

In vitro and in vivo efficacy of acid-sensitive transferrin and albumin doxorubicin conjugates in a human xenograft panel and in the MDA-MB-435 mamma carcinoma model.
Kratz, F. and Roth, T. and Fichtner, I. and Schumacher, P. and Fiebig, H.H. and Unger, C.
Journal of Drug Targeting 8 : 305-318. 1 January 2000

1999

Pharmacokinetics of sterically stabilized hexadecylphosphocholine liposomes versus conventional liposomes and free hexadecylphosphocholine in tumor-free and human breast carcinoma bearing mice.
Arndt, D. and Zeisig, R. and Fichtner, I. and Teppke, A.D. and Fahr, A.
Breast Cancer Research and Treatment 58 (1): 71-80. November 1999

Anticancer drug sensitivity and expression of multidrug resistance markers in early passage human sarcomas.
Hoffmann, J. and Schmidt-Peter, P. and Haensch, W. and Naundorf, H. and Bunge, A. and Becker, M. and Fichtner, I.
Clinical Cancer Research 5 : 2198-2204. 1 August 1999

Expression of CD44 isoforms in human breast carcinoma xenografts is not influenced by the treatment of mice with cytostatics or (anti-) hormones.
Dehmel, A. and Becker, M. and Lemm, M. and Fichtner, I.
Anticancer Research 19 : 1977-1987. 1 May 1999

Differential kinetics of primitive hematopoietic cells assayed in vitro and in vivo during serum-free suspension culture of CD34+ blood progenitor cells.
Mobest, D. and Goan, S.R. and Junghahn, I. and Winkler, J. and Fichtner, I. and Hermann, V. and Becker, M. and de Lima-Hahn, E. and Henschler, R.
Stem Cells 17 : 152-161. 1 January 1999

Ex vivo expanded CD34+ blood progenitor cells display lymphomyeloid plus stromal cell differentiation potential after transplantation into NOD/SCID mice.
Goan, S.R. and Junghahn, I. and Fichtner, I. and Becker, M. and Just, U. and Moebest, D. and Henschler, R.
In: Relevance of Tumor Models for Anticancer Drug Development. Contibutions to Oncology . Karger, Basel, 219-232. 1 January 1999

The chemokine RANTES is secreted by human melanoma cells and is associated with enhanced tumour formation in nude mice.
Mrowietz, U. and Schwenk, U. and Maune, S. and Bartels, J. and Kuepper, M. and Fichtner, I. and Schroeder, J.M. and Schadendorf, D.
British Journal of Cancer 79 : 1025-1031. 1 January 1999

Transplantation of human haematopoietic or leukaemic cells into SCID and NOD/SCID mice.
Fichtner, I. and Goan, S.R. and Becker, M. and Baldy, C. and Borgmann, A. and von Stackelberg, A. and Henze, H.
In: Relevance of Tumor Models for Anticancer Drug Development. Contibutions to Oncology . Karger, Basel, 207-217. 1 January 1999

1998

Alkylphospholipid liposomes: Preparation, properties and use in cancer research.
Arndt, D. and Zeisig, R. and Fichtner, I.
Drugs of Today 34 Suppl. F : 83-96. 1 December 1998

Physical properties and pharmacological activity in vitro and in vivo of optimised liposomes prepared from a new cancerostatic alkylphospholipid.
Zeisig, R. and Arndt, D. and Stahn, R. and Fichtner, I.
Biochimica et Biophysica Acta - Biomembranes 1414 (1-2): 238-248. 11 November 1998

Carboplatin oder Lobaplatin enthaltende Zubereitungen zur Antitumortherapie und/oder Stimulierung des haematopoetischen Systems.
Reszka, R. and Fichtner, I.
EP0611303 ; US5,620,703. 2 July 1998

Verwendung von Nucleosiden, Nucleobasen und deren Derivaten zum Herabsetzen toxischer Nebenwirkungen von Cytostatika.
Langen, P. and Schuett, M. and Koberling, A. and Ihn, L. and Fichtner, I.
DE19652418A1. 10 June 1998

Verfahren zum Nachweis der Malignitaet okkulter Tumorzellen in Koerperfluessigkeiten.
Fichtner, I. and Nowak, C.
DE19640328A1 ; DE19640328C2. 12 March 1998

Verfahren zum Nachweis einer Hormon- bzw. Antihormonresistenz bei Tumoren [Method for detecting a hormone or antihormone resistance in cancers].
Naundorf, H. and Fiebig, C. and Neumann, C. and Fichtner, I. and Becker, M.
DE19628298A1 ; DE19628298C2 ; EP0923739 ; US6,177,255. 15 January 1998

1-beta-D-Arabinofuranosylcytosine-5'-alkylphosphonophosphates and diphosphates: new orally active derivatives of ara-C.
Brachwitz, H. and Bergmann, J. and Fichtner, I. and Thomas, Y. and Vollgraf, C. and Langen, P. and Berdel, W.E.
Journal of Lipid Research 39 : 162-172. 1 January 1998

IR-spectroscopy and IR-microscopy of human breast tumors, xenografted breast tumors, and breast tumor cell lines.
Fabian, H. and Wessel, R. and Jackson, M. and Schwartz, A. and Lasch, P. and Fichtner, I. and Mantsch, H.H. and Naumann, D.
In: Infrared Spectroscopy: New Tool in Medicine. Proceedings of Infrared Spectroscopy: New Tool in Medicine : 28-30 January 1998, San Jose, California. SPIE Proceedings Series ; 3257 . SPIE, Bellingham, Wash., [s.p.]. 1 January 1998

In vivo evaluation of a cytostatic drug-inducible vector for the expression of TNF-alpha.
Walther, W. and Stein, U. and Fichtner, I. and Shoemaker, R.H. and Alexander, M. and Schlag, P.M.
Proceedings of the American Association of Cancer Research 39 : 520. 1 January 1998

In vivo evaluation of a drug-inducible vector system for the combined gene- and chemotherapy of cancer.
Walther, W. and Stein, U. and Fichtner, I. and Naundorf, H. and Alexander, M. and Shoemaker, R.H. and Schlag, P.M.
Advances in Experimental Medicine and Biology 451 : 139-144. 1 January 1998

1997

Verwendung von Carboplatin in lyotrophen Mesophasen zur Ueberwindung einer durch Zytostatika ausgeloesten Leukopenie.
Reszka, R. and Fichtner, I.
DE4134158C2. 13 February 1997

Antineoplastic activity of sterically stabilized alkylphosphocholine liposomes in human breast carcinomas.
Arndt, D. and Zeisig, R. and Eue, I. and Sternberg, B. and Fichtner, I.
Breast Cancer Research and Treatment 43 : 237-246. 1 January 1997

Body distribution of free, liposomal and nanoparticle-associated mitoxantrone in B16-melanoma-bearing mice.
Reszka, R. and Beck, P. and Fichtner, I. and Hentschel, M. and Richter, J. and Kreuter, J.
Journal of Pharmacology and Experimental Therapeutics 280 : 232-237. 1 January 1997

Bromelain proteases suppress growth, invasion and lung metastasis of B16F10 mouse melanoma cells.
Grabowska, E. and Eckert, K. and Fichtner, I. and Schulze-Forster, K. and Maurer, H.R.
International Journal of Oncology 11 : 243-248. 1 January 1997

Development and characterisation of novel human multidrug resistant mammary carcinoma lines in vitro and in vivo.
Stein, U. and Walther, W. and Lemm, M. and Naundorf, H. and Fichtner, I.
International Journal of Cancer 72 : 885-891. 1 January 1997

Development and characterization of novel multidrug resistant breast cancer lines.
Walther, W. and Stein, U. and Lemm, M. and Naundorf, H. and Fichtner, I.
Proceedings of the American Association of Cancer Research 38 : 484. 1 January 1997

Effects of amifostine (WR-2721, ethyol) on tumor growth and pharmacology of cytotoxic drugs in human xenotransplanted neuroblastomas.
Fichtner, I. and Lemm, M. and Becker, M. and Berthold, F.
Anti-Cancer Drugs 8 : 174-181. 1 January 1997

Encapsulation of the transition metal compounds Carboplatin (CP) and Lobaplatin (LP) in different types ofliposomes and their physico-chemical, biochemical and biological characterization.
Reszka, R. and Fichtner, I. and Goan, S.R. and Rudolph, M. and Winter, R.
In: Bioinorganic Chemistry - Transition Metals in Biology and their Coordination in Chemistry. Wiley-VCH, Weinheim, 145-166. 1 January 1997

Expression of CD44 standard and isoforms in human breast cancer xenografts and shedding of soluble forms into serum of nude mice.
Fichtner, I. and Dehmel, A. and Naundorf, H. and Finke, L.H.
Anticancer Research 17 : 3633-3646. 1 January 1997

1996

Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro, and causes growth inhibition in xenografts in vivo.
Schadendorf, D. and Kern, M.A. and Artuc, M. and Pahl, H.L. and Rosenbach, T. and Fichtner, I. and Nuernberg, W. and Stueting, S. and von Stebut, E. and Worm, M. and Makki, A. and Jurgovsky, K. and Kolde, G. and Henz, B.M.
Journal of Cell Biology 135 (6 Pt 2): 1889-1898. December 1996

Fibroblasts retrovirally transfected with the human IL-3 gene initiate and sustain multilineage human hematopoiesis in SCID mice: comparison of CD34-enriched vs CD34-enriched and in vitro expanded grafts.
Goan, S.R. and Schwarz, K. and von Harsdorf, S. and von Schilling, C. and Fichtner, I. and Junghahn, I. and Just, U. and Herrmann, F.
Bone Marrow Transplantation 18 : 513-519. 1 September 1996

Liposomal verkapseltes Taxol, seine Herstellung und seine Verwendung.
Reszka, R. and Brandl, M. and Fichtner, I. and Warnke, G.
DE4430593A1 ; EP0776202A1 ; EP0776202B1 ; US6,090,955. 22 February 1996

Verfahren zur Herstellung von liposomal verkapseltem Taxol.
Reszka, R. and Brandl, M. and Fichtner, I. and Warnke, G.
DE4430593C2 ; DE4447770C2. 22 February 1996

Antineoplastic activity of alkylphosphocholines and alkylphosphochiline liposomes: A review of recent knowledge.
Arndt, D. and Eue, I. and Fichtner, I. and Zeisig, R.
1 January 1996

Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo.
Shi, D.F. and Bradshaw, T.D. and Wrigley, S. and McCall, C.J. and Lelieveld, P. and Fichtner, I. and Stevens, M.F.G.
Journal of Medicinal Chemistry 39 : 3375-3384. 1 January 1996

Cell type specific and inducible promoters for vectors in gene therapy as an approach for cell targeting.
Walther, W. and Stein, U.
Journal of Molecular Medicine 74 : 379-392. 1 January 1996

Detektion Mamma-Karzinom-spezifischer Proteine aus dem Serum xenotransplantierter Nacktmaeuse mittels differentieller zweidimensionaler Elektrophorese.
Vogel, T. and Dehmel, A. and Otto, A. and Fichtner, I. and Kaisers, H. and Schlag, P.M.
Langenbecks Archiv fuer Chirurgie Suppl.I : 537-542. 1 January 1996

Drug-inducible vector for the conditional expression of the human TNFalpha gene.
Walther, W. and Stein, U. and Wendt, J. and Shoemaker, R.H.
Proceedings of the American Association of Cancer Research 37 : 350. 1 January 1996

Effects of liposomes with defined fatty acid composition on xenotransplanted human mammary carcinomas.
Zschiesche, W. and Naundorf, H. and Reszka, R. and Saul, G.J. and Fichtner, I.
In: Immunodeficient Animals: Models for Cancer Research. Contributions to Oncology ; 51, 51 . Karger, Basel, 138-141. 1 January 1996

Establishment and characterization of human sarcoma lines transplanted into nude mice.
Hoffmann, J. and Stein, U. and Schmidt-Peter, P. and Haensch, W. and Naundorf, H. and Scheper, R.J. and Fichtner, I.
In: Immunodeficient Animals: Models for Cancer Research. Contributions to Oncology ; 51 . Karger, Basel, 57-60. 1 January 1996

Establishment and characterization of human xenotransplanted breast carcinoma lines: use for the screening of alkylphosphocholines (APC).
Fichtner, I. and Naundorf, H. and Saul, G.J. and Zschiesche, W. and Zeisig, R.
In: Immunodeficient Animals: Models for Cancer Research. Contributions to Oncology ; 51, 51 . Karger, Basel, 129-133. 1 January 1996

Immunodeficient Animals: Models for Cancer Research.
Arnold, W. and Koepf-Maier, P. and Micheel, B.
Contributions to Oncology ; 51 . Karger, Basel. 1 January 1996

Influence of estradiol and tamoxifen on the growth and regulation of C-erbB-2, estradiol and progesterone receptors of mammary carcinoma 3366 transplanted into nude mice.
Naundorf, H. and Zschiesche, W. and Reineke, S. and Saul, G.J. and Frege, J. and Buettner, B. and Fichtner, I.
In: Immunodeficient Animals: Models for Cancer Research. Contributions to Oncology ; 51, 51 . Karger, Basel, 134-137. 1 January 1996

Involvement of macrophages and cytokines into rejection mechanism of the drug-resistant and immunogenic murine lymphoma P388/adria.
Kisseleva, E. and Becker, M. and Lemm, M. and Fichtner, I.
Anticancer Research 16 : 1971-1978. 1 January 1996

MDR1 gene expression: evaluation of its use as a molecular marker for prognosis and chemotherapy of bone and soft tissue sarcomas.
Stein, U. and Shoemaker, R.H. and Schlag, P.M.
European Journal of Cancer 32 A : 86-92. 1 January 1996

Metastatic potential of human melanoma cells in nude mice - characterisation of phenotype, cytokine secretion and tumour-associated antigens.
Schadendorf, D. and Fichtner, I. and Makki, A. and Alijagic, S. and Kuepper, M. and Mrowietz, U. and Henz, B.M.
British Journal of Cancer 74 : 194-199. 1 January 1996

Modulation of mdr1 expression by cytokines in human colon carcinoma cells: an approach for reversal of multidrug resistance.
Stein, U. and Walther, W. and Shoemaker, H.
British Journal of Cancer 74 : 1384-1391. 1 January 1996

Peripheral blood stem cell-initiated human hematopoiesis in severe combined immunodeficient (SCID) mice is accelerated by a rat fibroblast cell line retrovirally transfected with the human IL-3 gene.
Goan, S.R. and Fichtner, I. and Just, J. and Krause, K.P. and Karawajew, L. and Schwarz, K. and von Harsdorf, R. and von Schilling, C. and Herrmann, F.
In: Immunodeficient Animals: Models of Cancer Research. Contributions to Oncology ; 51 . Karger, Basel, 171-175. 1 January 1996

Preparation and properties of alkylphospholipid liposomes: a review.
Zeisig, R. and Fichtner, I. and Arndt, D.
Cellular and Molecular Biology Letters 1 : 447-457. 1 January 1996

Preparation and properties of sterically stabilized hexadecylphosphochiline (miltefosine)-liposomes and influence of this modification on macrophage activation.
Zeisig, R. and Eue, I. and Kosch, M. and Fichtner, I. and Arndt, D.
Biochimica et Biophysica Acta 1283 : 177-184. 1 January 1996

Relation of oestradiol-mediated growth stimulation with the expression of c-erbB-2 protein in xenotransplanted oestradiol-receptor-positive and -negative breast carcinomas.
Naundorf, H. and Parczyk, K. and Zschiesche, W. and Reinecke, S. and Buettner, B. and Saul, G.J. and Sinn, B. and Fichtner, I.
Journal of Cancer Research and Clinical Oncology 122 : 14-20. 1 January 1996

Reversal of multidrug resistance by transduction of cytokine genes into human colon carcinoma cells.
Stein, U. and Walther, W. and Shoemaker, R.H.
Journal of the National Cancer Institute 88 : 1383-1392. 1 January 1996

Targeted vectors for gene therapy of cancer and retroviral infections.
Walther, W. and Stein, U.
Molecular Biotechnology 6 : 267-286. 1 January 1996

Vincristine induction of mutant and wild-type human multidrug-resitance promoters is cell- type-specific and dose-dependent.
Stein, U. and Walther, W. and Shoemaker, R.H.
Journal of Cancer Research and Clinical Oncology 122 : 275-282. 1 January 1996

Xenotransplantation of a novel hodgkin cell line HD-MyZ into SCID mice.
Bargou, R.C. and Mapara, M.Y. and Arnold, W. and Daniel, P.T. and Doerken, B.
In: Immunodeficient Animals: Models in Cancer Research. Contributions to Oncology ; 51 . Karger, Basel, 187-192. 1 January 1996

1995

Pharmazeutisches Mittel zur Tumortherapie.
Arndt, D. and Zeisig, R. and Fichtner, I.
DE4408011C1. 2 November 1995

Neue Nukleosid-Lipid-Addukte, ihre Herstellung und ihre pharmazeutische Verwendung [Novel nucleoside-lipid addition compounds, their production and their pharmaceutical use].
Brachwitz, H. and Langen, P. and Fichtner, I. and Berdel, W. and Baeseler, M. and Lachmann, U. and Dressler, K. and Thomas, Y.
DE4400310A1 ; EP0738274 ; WO9518816. 13 July 1995

The severe combined immunodeficient-human peripheral blood stem cell (SCID-huPBSC) mouse: a xenotransplant model for huPBSC-initiated hematopoiesis.
Goan, S.R. and Fichtner, I. and Just, U. and Karawajew, L. and Schultze, W. and Krause, K.P. and von Harsdorf, S. and von Schilling, C. and Herrmann, F.
Blood 86 (1): 89-100. 1 July 1995

A comparative infrared spectroscopic study of human breast tumors and breast tumor cell xenografts.
Fabian, H. and Jackson, M. and Murphy, L. and Watson, P.H. and Fichtner, I. and Mantsch, H.H.
Biospectroscopy 1 : 37-45. 1 January 1995

Alkylphosphocholines and alkylphosphocholine liposomes.
Arndt, D. and Zeisig, R. and Eue, I. and Fichtner, I.
Journal of Liposome Research 5 : 91-98. 1 January 1995

Carboplatin-liposomes (CPL) in immunodeficient mice: improved antitumor activity for breast carcinomas and stimulationof hematopoiesis.
Fichtner, I. and Reszka, R. and Goan, S.R. and Naundorf, H.
Medical Oncology 11 : 111-119. 1 January 1995

Gene transfer of human TNFalpha into glioblastoma cells permits modulation of mdr1 expression and potentiation of chemosensitivity.
Walther, W. and Stein, U. and Pfeil, D.
International Journal of Cancer 61 (6): 832-839. 1 January 1995

Influence of liposomes rich in unsaturated or saturated fatty acids on the growth of human xenotransplanted mammary carcinomas and on the levels of heart type fatty acid binding protein.
Naundorf, H. and Zschiesche, W. and Reszka, R. and Fichtner, I.
In Vivo 9 : 247-252. 1 January 1995

Macrophage mediated tumor toxicity of alkylphosphocholine liposomes.
Zeisig, R. and Jungmann, S. and Eue, I. and Daemen, T. and Fichtner, I. and Nissen, E. and Arndt, D.
In: Phospholipids: Characterization, Metabolism, and Novel Biological Applications : Proceedings of the 6th International Colloquium. AOCS Press, Champaign, 126-133. 1 January 1995

Pharmacological effects of carboplatin-liposomes (CPL) in mice: a review of present knowledge.
Fichtner, I. and Reszka, R. and Goan, S.R. and Naundorf, H. and Hentschel, M.
Journal of Liposome Research 5 : 75-89. 1 January 1995

1994

Stimulation of hematopoiesis by carboplatin-liposomes.
Fichtner, I. and Reszka, R. and Becker, M. and Lemm, M. and Richter, J. and Rudolph, M.
Journal of Liposome Research 4 (1): 43-69. March 1994

Antineoplastic activity of alkylphosphocholines (APC) in human breast carcinomas in vivo and in vitro: use of liposomes.
Fichtner, I. and Zeisig, R. and Naundorf, H. and Jungmann, S. and Arndt, D. and Asongwe, G. and Double, J.A. and Bibby, M.C.
Breast Cancer Research and Treatment 32 : 269-279. 1 January 1994

Characterization of four drug resistant P388 sublines: resistance/sensitivity in vivo, resistance- and proliferation-markers, immunogenicity.
Fichtner, I. and Stein, U. and Hoffmann, J. and Winterfeld, G. and Pfeil, D. and Hentschel, M.
Anticancer Research 14 : 1995-2004. 1 January 1994

Cytotoxic effects of alkylphosphocholines or alkylphosphocholine-liposomes and macrophages on tumor cells.
Zeisig, R. and Jungmann, S. and Fichtner, I. and Daemen, T. and Arndt, D.
Anticancer Research 14 : 1785-1790. 1 January 1994

Development and characterization of in vivo and in vitro tumor lines for investigation of the phenomenon of multidrug resistance in human sarcomas.
Hoffmann, J. and Stein, U. and Schmidt-Peter, P. and Haensch, W. and Naundorf, H. and Fichtner, I.
In: Recent Advances in Chemotherapy. Proceedings of the 18th International Congress of Chemotherapy, Stockholm. American Society for Microbiology, Washington, 885-887. 1 January 1994

Establishment and characteristics of two new human mammary carcinoma lines in nude mice with special reference to the estradiol receptor status and the importance of stroma for in vivo and in vitro-growth.
Naundorf, H. and Fichtner, I. and Elbe, B. and Saul, G.J. and Haensch, W. and Zschiesche, W. and Reinecke, S.
Breast Cancer Research and Treatment 32 : 187-196. 1 January 1994

Immunmodyfying properties of free and liposomal alkylphosphocholines.
Eue, I. and Zeisig, R. and Jungmann, S. and Fichtner, I. and Arndt, D.
European Journal of Cell Biology 63 : 16-16. 1 January 1994

Influence of different promoters on the expression of tumor necrosis factor alpha in LS174T human colon carcinoma cells.
Uckert, W. and Asche, O. and Mahanty, B. and Fichtner, I.
International Journal of Oncology 5 : 865-871. 1 January 1994

Multidrug resistance of murine leukemia cells characterization and correlation with cytochrome P-450 dependent activities, cytosolic calcium and cell cycle state.
Pfeil, D. and Bergmann, J. and Fichtner, I. and Stein, U. and Hentschel, M. and Rothe, I. and Goan, S.R.
Anticancer Research 14 : 571-576. 1 January 1994

1993

Carboplatin - liposomes as activators of hematopoiesis.
Fichtner, I. and Reszka, R. and Schuett, M. and Rudolph, M. and Becker, M. and Lemm, M. and Richter, J. and Berger, I.
Oncology Research 5 : 65-74. 1 January 1993

Establishment and characteristics of two new human mammary carcinoma lines serially transplantable in nude mice.
Naundorf, H. and Fichtner, I. and Saul, G.J. and Haensch, W. and Buettner, B.
Journal of Cancer Research and Clinical Oncology 119 : 652-656. 1 January 1993

Influence of polybutylcyanoacrylate nanoparticles and liposomes on the efficacy and toxicity of the anticancer drug mitoxantrone in murine tumour models.
Beck, P. and Kreuter, J. and Reszka, R. and Fichtner, I.
Journal of Microencapsulation 10 : 101-114. 1 January 1993

Retrovirus-mediated gene transfer of tumor necrosis factor alpha into colon carcinoma cells generates a growth inhibition.
Walther, W. and Fichtner, I. and Uckert, W.
Anticancer Research 13 : 1565-1574. 1 January 1993

In vivo characterization of immunogenicity of a mitoxantrone-resistant murine P388 leukemia.
Fichtner, I. and Reipert, B. and Becker, M. and Lemm, M.
In Vivo 7 (1): 73-80. January 1993

1992

Characterization of two human mammary carcinomas, MT-1 and MT-3, suitable for in vivo-testing of ether lipids and their derivatives.
Naundorf, H. and Rewasowa, E.C. and Fichtner, I. and Buettner, B. and Becker, M. and Goerlich, M.
Breast Cancer Research and Treatment 23 : 87-95. 1 January 1992

Establishment and characterization of a new human oestradiol- and progesteron-receptor-positive mammary carcinoma serially transplantable in nude mice.
Naundorf, H. and Fichtner, I. and Buettner, B. and Frege, J.
Journal of Cancer Research and Clinical Oncology 119 : 35-40. 1 January 1992

In vivo distribution and antitumor activity of liposomal 3',5'-0-dipalmitoyl-5-fluoro-2'-deoxyuridine.
van Borssum Waalkes, M. and Fichtner, I. and Dontjes, B. and Lemm, M. and Becker, M. and Arndt, D. and Scherphof, G.L.
Journal of Microencapsulation 9 : 335-346. 1 January 1992

Investigations of droloxifene and other hormonal manipulations on N-nitrosomethylurea- induced rat mammary tumors. 2. Influence on estrogen receptor.
Goerlich, M. and Winterfeld, G. and Hauff, P. and Arnold, W. and Fichtner, I. and Staab, H.J.
Journal of Cancer Research and Clinical Oncology 119 : 97-100. 1 January 1992

Investigations of droloxifene and other hormone manipulations on N-nitrosomethylurea-induced rat mammary tumors. 1. Influence on tumor growth.
Winterfeld, G. and Hauff, P. and Goerlich, M. and Arnold, W. and Fichtner, I. and Staab, H.J.
Journal of Cancer Research and Clinical Oncology 119 : 91-96. 1 January 1992

Measurements of carbon clearance in mice as toxicity parameter for liposomal preparations.
Fichtner, I. and Kniest, A. and Arndt, D.
In Vivo 6 : 113-118. 1 January 1992

1991

Antitumor effects of alkylphosphocholines in different murine tumor models, use of liposomal preparations.
Zeisig, R. and Fichtner, I. and Arndt, D. and Jungmann, S.
Anti-Cancer Drugs 2 : 411-417. 1 January 1991

Messung der Bromsulfaleinretention der Maus als moeglicher Parameter zur Einschaetzung der Leberfunktion nach Gabe liposomaler Praeparationen.
Hoffmann, J. and Fichtner, I. and Becker, M. and Lemm, M.
Pharmazie 46 : 222-223. 1 January 1991

Pharmacokinetic behavior of 57CO-Bleomycin liposomes in mice: comparison with the unencapsulated substance.
Fichtner, I. and Arndt, D. and Reszka, R. and Gens, J.
Anti-Cancer Drugs 2 : 555-563. 1 January 1991

Stellenwert von Tierversuchen in der Onkologie. Moegliche Alternativen?
Fichtner, I.
Archiv fuer Geschwulstforschung 61 : 153-161. 1 January 1991

Tierexperimentelle Untersuchungen mit dem Immunsuppressivum Cyclosporin A (CSA) an syngenen Tumormodellen.
Ebert, A. and Fichtner, I. and Brandt, R. and Buettner, B.
Archiv fuer Geschwulstforschung 61 : 111-122. 1 January 1991

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