Browse by Research Team

2023

CAR links hypoxia signaling to improved survival after myocardial infarction.
Freiberg, F. and Thakkar, M. and Hamann, W. and Lopez Carballo, J. and Jüttner, R. and Voss, F.K. and Becher, P.M. and Westermann, D. and Tschöpe, C. and Heuser, A. and Rocks, O. and Fischer, R. and Gotthardt, M.
Experimental and Molecular Medicine 55 (3): 643-652. March 2023

2020

Morphine alleviates pain after heart cryoinjury in zebrafish without impeding regeneration.
Lelek, S. and Simões, M. and Hu, B. and Alameldeen, A.M.A. and Czajkowski, M.T. and Meyer, A.M. and Ferrara, F. and Junker, J.P. and Panáková, D.
bioRxiv : 2020.10.01.322560. 2 October 2020

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.
Müller, P.M. and Rademacher, J. and Bagshaw, R.D. and Wortmann, C. and Barth, C. and van Unen, J. and Alp, K.M. and Giudice, G. and Eccles, R.L. and Heinrich, L.E. and Pascual-Vargas, P. and Sanchez-Castro, M. and Brandenburg, L. and Mbamalu, G. and Tucholska, M. and Spatt, L. and Czajkowski, M.T. and Welke, R.W. and Zhang, S. and Nguyen, V. and Rrustemi, T. and Trnka, P. and Freitag, K. and Larsen, B. and Popp, O. and Mertins, P. and Gingras, A.C. and Roth, F.P. and Colwill, K. and Bakal, C. and Pertz, O. and Pawson, T. and Petsalaki, E. and Rocks, O.
Nature Cell Biology 22 (4): 498-511. April 2020

2018

Interaction modulation through arrays of clustered methyl-arginine protein modifications.
Woodsmith, J. and Casado-Medrano, V. and Benlasfer, N. and Eccles, R.L. and Hutten, S. and Heine, C.L. and Thormann, V. and Abou-Ajram, C. and Rocks, O. and Dormann, D. and Stelzl, U.
Life Science Alliance 1 (5): e201800178. October 2018

Spatial organization of Rho GTPase signaling by RhoGEF/RhoGAP proteins.
Müller, P.M. and Rademacher, J. and Bagshaw, R.D. and Alp, K.M. and Giudice, G. and Heinrich, L.E. and Barth, C. and Eccles, R.L. and Sanchez-Castro, M. and Brandenburg, L. and Mbamalu, G. and Tucholska, M. and Spatt, L. and Wortmann, C. and Czajkowski, M.T. and Welke, R.W. and Zhang, S. and Nguyen, V. and Rrustemi, T. and Trnka, P. and Freitag, K. and Larsen, B. and Popp, O. and Mertins, P. and Bakal, C. and Gingras, A.C. and Pertz, O. and Roth, F.P. and Colwill, K. and Pawson, T. and Petsalaki, E. and Rocks, O.
bioRxiv : 354316. 29 August 2018

Cumulative regulatory potential of clustered methyl-arginine protein modifications.
Woodsmith, J. and Casado-Medrano, V. and Benlasfer, N. and Eccles, R.L. and Hutten, S. and Heine, C. and Thormann, V. and Abou-Ajram, C. and Rocks, O. and Dormann, D. and Stelzl, U.
bioRxiv : 289041. 26 March 2018

An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.
Schrade, K. and Tröger, J. and Eldahshan, A. and Zühlke, K. and Abdul Azeez, K.R. and Elkins, J.M. and Neuenschwander, M. and Oder, A. and Elkewedi, M.M.H. and Jaksch, S. and Andrae, K. and Li, J. and Fernandes, J. and Müller, P.M. and Grunwald, S. and Marino, S.F. and Vukićević, T. and Eichhorst, J. and Wiesner, B. and Weber, M. and Kapiloff, M. and Rocks, O. and Daumke, O. and Wieland, T. and Knapp, S. and von Kries, J.P. and Klussmann, E.
PLoS ONE 13 (1): e0191423. 26 January 2018

2017

Quantitative GTPase affinity purification identifies Rho family protein interaction partners.
Paul, F. and Zauber, H. and von Berg, L. and Rocks, O. and Daumke, O. and Selbach, M.
Molecular & Cellular Proteomics 16 (1): 73-85. 1 January 2017

2016

Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
Arumughan, A. and Roske, Y. and Barth, C. and Lleras Forero, L. and Bravo-Rodriguez, K. and Redel, Al. and Kostova, S. and McShane, E. and Opitz, R. and Faelber, K. and Rau, K. and Mielke, T. and Daumke, O. and Selbach, M. and Sanchez-Garcia, E. and Rocks, O. and Panáková, D. and Heinemann, U. and Wanker, E.E.
Nature Communications 7 : 13047. 20 October 2016

Bimodal antagonism of PKA signalling by ARHGAP36.
Eccles, R.L. and Czajkowski, M.T. and Barth, C. and Müller, P.M. and McShane, E. and Grunwald, S. and Beaudette, P. and Mecklenburg, N. and Volkmer, R. and Zühlke, K. and Dittmar, G. and Selbach, M. and Hammes, A. and Daumke, O. and Klussmann, E. and Urbé, S. and Rocks, O.
Nature Communications 7 : 12963. 7 October 2016

The anticancer phytochemical rocaglamide inhibits Rho GTPase activity and cancer cell migration.
Becker, M.S. and Müller, P.M. and Bajorat, J. and Schroeder, A. and Giaisi, M. and Amin, E. and Ahmadian, M.R. and Rocks, O. and Köhler, R. and Krammer, P.H. and Li-Weber, M.
Oncotarget 7 (32): 51908-51921. 9 August 2016

A new role of the Rac-GAP β2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression.
Casado-Medrano, V. and Barrio-Real, L. and García-Rostán, G. and Baumann, M. and Rocks, O. and Caloca, M.J.
Oncotarget 7 (19): 28301-28319. 10 May 2016

2014

Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP.
Gray, E.J. and Petsalaki, E. and James, D.A. and Bagshaw, R.D. and Stacey, M.M. and Rocks, O. and Gingras, A.C. and Pawson, T.
Journal of Biological Chemistry 289 (51): 35397-35408. 19 December 2014

2013

Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein.
Fröhlich, C. and Grabiger, S. and Schwefel, D. and Faelber, K. and Rosenbaum, E. and Mears, J. and Rocks, O. and Daumke, O.
EMBO Journal 32 (9): 1280-1292. 2 May 2013

Structural insights into the mechanism of GTPase activation in the GIMAP family.
Schwefel, D. and Arasu, B.S. and Marino, S.F. and Lamprecht, B. and Köchert, K. and Rosenbaum, E. and Eichhorst, J. and Wiesner, B. and Behlke, J. and Rocks, O. and Mathas, S. and Daumke, O.
Structure 21 (4): 550-559. 2 April 2013

2011

A roadmap to generate renewable protein binders to the human proteome.
Colwill, K. and Graeslund, S.
Nature Methods 8 (7): 551-558. 15 May 2011

2010

Regulation of Ras localization by acylation enables a mode of intracellular signal propagation.
Lorentzen, A. and Kinkhabwala, A. and Rocks, O. and Vartak, N. and Bastiaens, P.I.
Science Signaling 3 (140): ra68. 21 September 2010

Small-molecule inhibition of APT1 affects Ras localization and signaling.
Dekker, F.J. and Rocks, O. and Vartak, N. and Menninger, S. and Hedberg, C. and Balamurugan, R. and Wetzel, S. and Renner, S. and Gerauer, M. and Schoelermann, B. and Rusch, M. and Kramer, J.W. and Rauh, D. and Coates, G.W. and Brunsveld, L. and Bastiaens, P.I. and Waldmann, H.
Nature Chemical Biology 6 (6): 449-456. June 2010

The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins.
Rocks, O. and Gerauer, M. and Vartak, N. and Koch, S. and Huang, Z.P. and Pechlivanis, M. and Kuhlmann, J. and Brunsveld, L. and Chandra, A. and Ellinger, B. and Waldmann, H. and Bastiaens, P.I.
Cell 141 (3): 458-471. 30 April 2010

2006

An experimental setup for frequency domain FLIM.
Verveer, P.J. and Rocks, O. and Harpur, A.G. and Bastiaens, P.I.H.
Cold Spring Harbor Protocols 2006 (6) 1 November 2006

FLIM measurements and frequency domain FLIM data analysis.
Verveer, P.J. and Rocks, O. and Harpur, A.G. and Bastiaens, P.I.H.
Cold Spring Harbor Protocols 2006 (6) 1 November 2006

Imaging protein interactions by FRET microscopy: FLIM measurements.
Verveer, P.J. and Rocks, O. and Harpur, A.G. and Bastiaens, P.I.H.
Cold Spring Harbor Protocols 2006 (6) 1 November 2006

Imaging protein interactions by FRET microscopy: FRET measurements by acceptor photobleaching.
Verveer, P.J. and Rocks, O. and Harpur, A.G. and Bastiaens, P.I.H.
Cold Spring Harbor Protocols 2006 (6) 1 November 2006

Imaging protein interactions by FRET microscopy: FRET measurements by sensitized emission.
Verveer, P.J. and Rocks, O. and Harpur, A.G. and Bastiaens, P.I.H.
Cold Spring Harbor Protocols 2006 (6) 1 November 2006

Imaging protein interactions by FRET microscopy: cell preparation for FRET analysis.
Verveer, P.J. and Rocks, O. and Harpur, A.G. and Bastiaens, P.I.H.
Cold Spring Harbor Protocols 2006 (6) 1 November 2006

Imaging protein interactions by FRET microscopy: labeling proteins with fluorescent dyes.
Verveer, P.J. and Rocks, O. and Harpur, A.G. and Bastiaens, P.I.H.
Cold Spring Harbor Protocols 2006 (6) 1 November 2006

Measuring FRET by acceptor photobleaching.
Verveer, P.J. and Rocks, O. and Harpur, A.G. and Bastiaens, P.I.H.
Cold Spring Harbor Protocols 2006 (6) 1 November 2006

Measuring FRET by sensitized emission.
Verveer, P.J. and Rocks, O. and Harpur, A.G. and Bastiaens, P.I.H.
Cold Spring Harbor Protocols 2006 (6) 1 November 2006

Spatio-temporal segregation of Ras signals: one ship, three anchors, many harbors.
Rocks, O. and Peyker, A. and Bastiaens, P.I.
Current Opinion in Cell Biology 18 (4): 351-357. August 2006

2005

An acylation cycle regulates localization and activity of palmitoylated Ras isoforms.
Rocks, O. and Peyker, A. and Kahms, M. and Verveer, P.J. and Koerner, C. and Lumbierres, M. and Kuhlmann, J. and Waldmann, H. and Wittinghofer, A. and Bastiaens, P.I.
Science 307 (5716): 1746-1752. 18 March 2005

Imaging activation of two Ras isoforms simultaneously in a single cell.
Peyker, A. and Rocks, O. and Bastiaens, P.I.
ChemBioChem 6 (1): 78-85. January 2005

2004

Red-edge anisotropy microscopy enables dynamic imaging of homo-FRET between green fluorescent proteins in cells.
Squire, A. and Verveer, P.J. and Rocks, O. and Bastiaens, P.I.
Journal of Structural Biology 147 (1): 62-69. July 2004

2003

EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation.
Reynolds, A.R. and Tischer, C. and Verveer, P.J. and Rocks, O. and Bastiaens, P.I.
Nature Cell Biology 5 (5): 447-453. May 2003

2002

Structural domains required for channel function of the mouse transient receptor potential protein homologue TRP1beta.
Engelke, M. and Friedrich, O. and Budde, P. and Schaefer, C. and Niemann, U. and Zitt, C. and Juengling, E. and Rocks, O. and Lueckhoff, A. and Frey, J.
FEBS Letters 523 (1-3): 193-199. 17 July 2002

1999

Adenine nucleotide translocase-1, a component of the permeability transition pore, can dominantly induce apoptosis.
Bauer, M.K.A. and Schubert, A. and Rocks, O. and Grimm, S.
Journal of Cell Biology 147 (7): 1493-1502. 27 December 1999