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Spatio-temporal segregation of Ras signals: one ship, three anchors, many harbors

Item Type:Article
Title:Spatio-temporal segregation of Ras signals: one ship, three anchors, many harbors
Creators Name:Rocks, O. and Peyker, A. and Bastiaens, P.I.
Abstract:Dynamic assembly of spatially separated signaling platforms enables a cell to tune cellular outputs in response to different input stimuli. Understanding how a vast diversity in signaling responses can be generated from a limited protein repertoire requires knowledge of how cells maintain the segregation of proteins and thereby orchestrate their local activities. Ras proteins are subject to this type of precise regulation of localization, and thus activity, in space and time. A model emerges where different lipid anchors dynamically shuttle Ras between specific membrane compartments, where differences in the accessibility of signaling environments and in the residence time of Ras therein account for isoform-specific signaling responses.
Keywords:Cell Membrane, Golgi Apparatus, Biological Models, Signal Transduction, ras Proteins, Animals
Source:Current Opinion in Cell Biology
ISSN:0955-0674
Publisher:Elsevier (the Netherlands)
Volume:18
Number:4
Page Range:351-357
Date:August 2006
Official Publication:https://doi.org/10.1016/j.ceb.2006.06.007
PubMed:View item in PubMed

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