Browse by Journal Title

2024

A type 1 immunity-restricted promoter of the IL-33 receptor gene directs antiviral T-cell responses.
Brunner, T.M., Serve, S., Marx, A.F., Fadejeva, J., Saikali, P., Dzamukova, M., Durán-Hernández, N., Kommer, C., Heinrich, F., Durek, P., Heinz, G.A., Höfer, T., Mashreghi, M.F., Kühn, R., Pinschewer, D.D. and Löhning, M.
Nature Immunology 25 (2): 256-267. February 2024

GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway.
Park, A.Y., Leney-Greene, M., Lynberg, M., Gabrielski, J.Q., Xu, X., Schwarz, B., Zheng, L., Balasubramaniyam, A., Ham, H., Chao, B., Zhang, Y., Matthews, H.F., Cui, J., Yao, Y., Kubo, S., Chanchu, J.M., Morawski, A.R., Cook, S.A., Jiang, P., Ravell, J.C., Cheng, Y.H., George, A., Faruqi, A., Pagalilauan, A.M., Bergerson, J.R.E., Ganesan, S., Chauvin, S.D., Aluri, J., Edwards-Hicks, J., Bohrnsen, E., Tippett, C., Omar, H., Xu, L., Butcher, G.W., Pascall, J., Karakoc-Aydiner, E., Kiykim, A., Maecker, H., Tezcan, İ., Esenboga, S., Heredia, R.J., Akata, D., Tekin, S., Kara, A., Kuloglu, Z., Unal, E., Kendirli, T., Dogu, F., Karabiber, E., Atkinson, T.P., Cochet, C., Filhol, O., Bosio, C.M., Davis, M.M., Lifton, R.P., Pearce, E.L., Daumke, O., Aytekin, C., Şahin, G.E., Aksu, A.Ü., Uzel, G., Koneti Rao, V., Sari, S., Boztug, K., Cagdas, D., Haskologlu, S., Ikinciogullari, A., Schwefel, D., Vilarinho, S., Baris, S., Ozen, A., Su, H.C. and Lenardo, M.J.
Nature Immunology 25 (2): 282-293. February 2024

2023

Harnessing CD3 diversity to optimize CAR T cells.
Velasco Cárdenas, R.M.H., Brandl, S.M., Meléndez, A.V., Schlaak, A.E., Buschky, A., Peters, T., Beier, F., Serrels, B., Taromi, S., Raute, K., Hauri, S., Gstaiger, M., Lassmann, S., Huppa, J.B., Boerries, M., Andrieux, G., Bengsch, B., Schamel, W.W. and Minguet, S.
Nature Immunology 24 (12): 2135-2149. December 2023

IFNγ binding to extracellular matrix prevents fatal systemic toxicity.
Kemna, J., Gout, E., Daniau, L., Lao, J., Weißert, K., Ammann, S., Kühn, R., Richter, M., Molenda, C., Sporbert, A., Zocholl, D., Klopfleisch, R., Schütz, A., Lortat-Jacob, H., Aichele, P., Kammertoens, T. and Blankenstein, T.
Nature Immunology 24 (3): 414-422. March 2023

Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells.
Horkova, V., Drobek, A., Paprckova, D., Niederlova, V., Prasai, A., Uleri, V., Glatzova, D., Kraller, M., Cesnekova, M., Janusova, S., Salyova, E., Tsyklauri, O., Kadlecek, T.A., Krizova, K., Platzer, R., Schober, K., Busch, D.H., Weiss, A., Huppa, J.B. and Stepanek, O.
Nature Immunology 24 (1): 174-185. January 2023

2022

Clonal expansion and epigenetic inheritance of long-lasting NK cell memory.
Rückert, T., Lareau, C.A., Mashreghi, M.F., Ludwig, L.S. and Romagnani, C.
Nature Immunology 23 (11): 1551-1563. November 2022

Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo.
Subramanian, S., Busch, C.J.L., Molawi, K., Geirsdottir, L., Maurizio, J., Vargas Aguilar, S., Belahbib, H., Gimenez, G., Yuda, R.A.A., Burkon, M., Favret, J., Gholamhosseinian Najjar, S., de Laval, B., Kandalla, P.K., Sarrazin, S., Alexopoulou, L. and Sieweke, M.H.
Nature Immunology 23 (3): 458-468. March 2022

2021

Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states.
Triana, S., Vonficht, D., Jopp-Saile, L., Raffel, S., Lutz, R., Leonce, D., Antes, M., Hernández-Malmierca, P., Ordoñez-Rueda, D., Ramasz, B., Boch, T., Jann, J.C., Nowak, D., Hofmann, W.K., Müller-Tidow, C., Hübschmann, D., Alexandrov, T., Benes, V., Trumpp, A., Paulsen, M., Velten, L. and Haas, S.
Nature Immunology 22 (12): 1577-1589. December 2021

Trained immunity, tolerance, priming and differentiation: distinct immunological processes.
Divangahi, M., Aaby, P.r, Khader, S.A., Barreiro, L.B., Bekkering, S., Chavakis, T., van Crevel, R., Curtis, N., DiNardo, A.R., Dominguez-Andres, J., Duivenvoorden, R., Fanucchi, S., Fayad, Z., Fuchs, E., Hamon, M., Jeffrey, K.L., Khan, N., Joosten, L.A.B., Kaufmann, E., Latz, E., Matarese, G., van der Meer, J.W.M., Mhlanga, M., Moorlag, S.J.C.F.M., Mulder, W.J.M., Naik, S., Novakovic, B., O'Neill, L., Ochando, J., Ozato, K., Riksen, N.P., Sauerwein, R., Sherwood, E.R., Schlitzer, A., Schultze, J.L., Sieweke, M.H., Benn, C.S., Stunnenberg, H., Sun, J., van de Veerdonk, F.L., Weis, S., Williams, D.L., Xavier, R. and Netea, M.G.
Nature Immunology 22 (1): 2-6. January 2021

2020

Inefficient CAR-proximal signaling blunts antigen sensitivity.
Gudipati, V., Rydzek, J., Doel-Perez, I., Gonçalves, V.D.R., Scharf, L., Königsberger, S., Lobner, E., Kunert, R., Einsele, H., Stockinger, H., Hudecek, M. and Huppa, J.B.
Nature Immunology 21 (8): 848-856. August 2020

Cxcl10(+) monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation.
Giladi, A., Wagner, L.K., Li, H., Dörr, D., Medaglia, C., Paul, F., Shemer, A., Jung, S., Yona, S., Mack, M., Leutz, A., Amit, I. and Mildner, A.
Nature Immunology 21 (5): 525-534. May 2020

2019

Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils.
Fischer, J., Walter, C., Tönges, A., Aleth, H., Costa Jordão, M.J., Leddin, M., Gröning, V., Erdmann, T., Lenz, G., Roth, J., Vogl, T., Prinz, M., Dugas, M., Jacobsen, I.D. and Rosenbauer, F.
Nature Immunology 20 (5): 546-558. May 2019

2018

TCRs are randomly distributed on the plasma membrane of resting antigen-experienced T cells.
Rossboth, B., Arnold, A.M., Ta, H., Platzer, R., Kellner, F., Huppa, J.B., Brameshuber, M., Baumgart, F. and Schütz, G.J.
Nature Immunology 19 (8): 821-827. August 2018

Monomeric TCRs drive T cell antigen recognition.
Brameshuber, M., Kellner, F., Rossboth, B.K., Ta, H., Alge, K., Sevcsik, E., Göhring, J., Axmann, M., Baumgart, F., Gascoigne, N.R.J., Davis, S.J., Stockinger, H., Schütz, G.J. and Huppa, J.B.
Nature Immunology 19 (5): 487-496. May 2018

c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4(+) T cells.
Gabryšová, L., Alvarez-Martinez, M., Luisier, R., Cox, L.S., Sodenkamp, J., Hosking, C., Pérez-Mazliah, D., Whicher, C., Kannan, Y., Potempa, K., Wu, X., Bhaw, L., Wende, H., Sieweke, M.H., Elgar, G., Wilson, M., Briscoe, J., Metzis, V., Langhorne, J., Luscombe, N.M. and O'Garra, A.
Nature Immunology 19 (5): 497-507. May 2018

Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells.
Hammer, Q., Rückert, T., Borst, E.M., Dunst, J., Haubner, A., Durek, P., Heinrich, F., Gasparoni, G., Babic, M., Tomic, A., Pietra, G., Nienen, M., Blau, I.W., Hofmann, J., Na, I.K., Prinz, I., Koenecke, C., Hemmati, P., Babel, N., Arnold, R., Walter, J., Thurley, K., Mashreghi, M.F., Messerle, M. and Romagnani, C.
Nature Immunology 19 (5): 453-463. May 2018

2017

Trained macrophages support hygiene hypothesis.
de Laval, B. and Sieweke, M.H.
Nature Immunology 18 (12): 1279-1280. 16 November 2017

Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis.
Duchene, J., Novitzky-Basso, I., Thiriot, A., Casanova-Acebes, M., Bianchini, M., Etheridge, S.L., Hub, E., Nitz, K., Artinger, K., Eller, K., Caamano, J., Ruelicke, T., Moss, P., Megens, R.T.A., von Andrian, U.H., Hidalgo, A., Weber, C. and Rot, A.
Nature Immunology 18 (7): 753-761. July 2017

2016

RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics.
Salzer, E., Cagdas, D., Hons, M., Mace, E.M., Garncarz, W., Petronczki, Ö.Y., Platzer, R., Pfajfer, L., Bilic, I., Ban, S.A., Willmann, K.L., Mukherjee, M., Supper, V., Hsu, H.T., Banerjee, P.P., Sinha, P., McClanahan, F., Zlabinger, G.J., Pickl, W.F., Gribben, J.G., Stockinger, H., Bennett, K.L., Huppa, J.B., Dupré, L., Sanal, Ö., Jäger, U., Sixt, M., Tezcan, I., Orange, J.S. and Boztug, K.
Nature Immunology 17 (12): 1352-1360. December 2016

Eosinophils and mast cells: a lineage apart.
Sarrazin, S. and Sieweke, M.H.
Nature Immunology 17 (6): 609-611. 19 May 2016

2015

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.
Finkin, S., Yuan, D., Stein, I., Taniguchi, K., Weber, A., Unger, K., Browning, J.L., Goossens, N., Nakagawa, S., Gunasekaran, G., Schwartz, M.E., Kobayashi, M., Kumada, H., Berger, M., Pappo, O., Rajewsky, K., Hoshida, Y., Karin, M., Heikenwalder, M., Ben-Neriah, Y. and Pikarsky, E.
Nature Immunology 16 (12): 1235-1244. December 2015

Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor.
Grajales-Reyes, G.E., Iwata, A., Albring, J., Wu, X., Tussiwand, R., Kc, W., Kretzer, N.M., Briseno, C.G., Durai, V., Bagadia, P., Haldar, M., Schoenheit, J., Rosenbauer, F., Murphy, T.L. and Murphy, K.M.
Nature Immunology 16 (7): 708-717. July 2015

2013

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells.
Guy, C.S., Vignali, K.M., Temirov, J., Bettini, M.L., Overacre, A.E., Smeltzer, M., Zhang, H., Huppa, J.B., Tsai, Y.H., Lobry, C., Xie, J., Dempsey, P.J., Crawford, H.C., Aifantis, I., Davis, M.M. and Vignali, D.A.A.
Nature Immunology 14 (3): 262-70. March 2013

Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach.
Lee, M.N., Roy, M., Ong, S.E., Mertins, P., Villani, A.C., Li, W., Dotiwala, F., Sen, J., Doench, J.G., Orzalli, M.H., Kramnik, I., Knipe, D.M., Lieberman, J., Carr, S.A. and Hacohen, N.
Nature Immunology 14 (2): 179-185. February 2013

T. rex attacks the lysosome.
Simon, A.K. and Ballabio, A.
Nature Immunology 14 (1): 10-2. January 2013

2012

The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers.
Calado, D.P., Sasaki, Y., Godinho, S.A., Pellerin, A., Köchert, K., Sleckman, B.P., de Alboran, I.M., Janz, M., Rodig, S. and Rajewsky, K.
Nature Immunology 13 (11): 1092-1100. November 2012

Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC.
Xie, J., Huppa, J.B., Newell, E.W., Huang, J., Ebert, P.J.R., Li, Q.J. and Davis, M.M.
Nature Immunology 13 (7): 674-80. July 2012

2011

Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk.
Biton, M., Levin, A., Slyper, M., Alkalay, I., Horwitz, E., Mor, H., Kredo-Russo, S., Avnit-Sagi, T., Cojocaru, G., Zreik, F., Bentwich, Z., Poy, M.N., Artis, D., Walker, M.D., Hornstein, E., Pikarsky, E. and Ben-Neriah, Y.
Nature Immunology 12 (3): 239-246. March 2011

2010

The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes.
Stittrich, A.B., Haftmann, C., Sgouroudis, E., Kuehl, A.A., Hegazy, A.N., Panse, I., Riedel, R., Flossdorf, M., Dong, J., Fuhrmann, F., Heinz, G.A., Fang, Z., Li, N., Bissels, U., Hatam, F., Jahn, A., Hammoud, B., Matz, M., Schulze, F.M., Baumgrass, R., Bosio, A., Mollenkopf, H.J., Gruen, J., Thiel, A., Chen, W., Hoefer, T., Loddenkemper, C., Loehning, M., Chang, H.D., Rajewsky, N., Radbruch, A. and Mashreghi, M.F.
Nature Immunology 11 (11): 1057-1062. November 2010

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.
Lillemeier, B.F., Mörtelmaier, M.A., Forstner, M.B., Huppa, J.B., Groves, J.T. and Davis, M.M.
Nature Immunology 11 (1): 90-6. January 2010

2009

Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation.
van de Pavert, S.A., Olivier, B.J., Goverse, G., Vondenhoff, M.F., Greuter, M., Beke, P., Kusser, K., Höpken, U.E., Lipp, M., Niederreither, K., Blomhoff, R., Sitnik, K., Agace, W.W., Randall, T.D., de Jonge, W.J. and Mebius, R.E.
Nature Immunology 10 (11): 1193-1199. November 2009

2006

Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation.
Scheller, M., Huelsken, J., Rosenbauer, F., Taketo, M.M., Birchmeier, W., Tenen, D.G. and Leutz, A.
Nature Immunology 7 (10): 1037-1047. October 2006

Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR.
Bilic, I., Koesters, C., Unger, B., Sekimata, M., Hertweck, A., Maschek, R., Wilson, C.B. and Ellmeier, W.
Nature Immunology 7 (4): 392-400. April 2006

Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma.
Mathas, S., Janz, M., Hummel, F., Hummel, M., Wollert-Wulf, B., Lusatis, S., Anagnostopoulos, I., Lietz, A., Sigvardsson, M., Jundt, F., Joehrens, K., Bommert, K., Stein, H. and Doerken, B.
Nature Immunology 7 (2): 207-215. February 2006

2005

Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues.
Debes, G.F., Arnold, C.N., Young, A.J., Krautwald, S., Lipp, M., Hay, J.B. and Butcher, E.C.
Nature Immunology 6 (9): 889-894. 14 August 2005

2004

CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse.
Li, Q.J., Dinner, A.R., Qi, S., Irvine, D.J., Huppa, J.B., Davis, M.M. and Chakraborty, A.K.
Nature Immunology 5 (8): 791-9. 1 August 2004

T cell killing does not require the formation of a stable mature immunological synapse.
Purbhoo, M.A., Irvine, D.J., Huppa, J.B. and Davis, M.M.
Nature Immunology 5 (5): 524-30. 1 May 2004

A cis element in the recombination activating gene locus regulates gene expression by counteracting a distant silencer.
Yannoutsos, N., Barreto, V., Misulovin, Z., Gazumyan, A., Yu, W., Rajewsky, N., Peixoto, B.R., Eisenreich, T. and Nussenzweig, M.C.
Nature Immunology 5 (4): 443-450. April 2004

Lymphoid organogenesis: getting the green light from RORgammat.
Lipp, M. and Mueller, G.
Nature Immunology 5 (1): 12-14. 1 January 2004

Induced recruitment of NK cells to lymph nodes provides IFN-gamma for TH1 priming.
Martin-Fontecha, A., Thomsen, L.L., Brett, S., Gerard, C., Lipp, M., Lanzavecchia, A. and Sallusto, F.
Nature Immunology 5 (12): 1260-1265. 1 January 2004

A cancer immunosurveillance controversy.
Qin, Z.H. and Blankenstein, T.
Nature Immunology 5 (1): 3-4. 1 January 2004

2003

Continuous T cell receptor signaling required for synapse maintenance and full effector potential.
Huppa, J.B., Gleimer, M., Sumen, C. and Davis, M.M.
Nature Immunology 4 (8): 749-55. 1 August 2003

Transcriptional profiling identifies Id2 function in dendritic cell development.
Hacker, C., Kirsch, R.D., Ju, X.S., Hieronymus, T., Gust, T.C., Kuhl, C., Jorgas, T., Kurz, S.M., Rose-John, S., Yokota, Y. and Zenke, M.
Nature Immunology 4 (4): 380-386. April 2003

Deletion of beta-catenin impairs T cell development.
Xu, Y., Banerjee, D., Huelsken, J., Birchmeier, W. and Sen, J.M.
Nature Immunology 4 (12): 1177-1182. 1 January 2003

2002

The final cut: how ERAP1 trims MHC ligands to size.
Falk, K. and Roetzschke, O.
Nature Immunology 3 (12): 1121-1122. December 2002

2001

Involvement of inhibitory NKRs in the survival of a subset of memory-phenotype CD8+ T cells.
Ugolini, S., Arpin, C., Anfossi, N., Walzer, T., Cambiaggi, A., Foerster, R., Lipp, M., Toes, R.E.M., Melief, C.J., Marvel, J. and Vivier, E.
Nature Immunology 2 (5): 430-435. 1 January 2001