Article

Enteric nervous system-derived VIP restrains differentiation of LGR(5)(+) stem cells toward the secretory lineage impeding type 2 immune programs.
Jakob, Manuel O. ORCID: https://orcid.org/0000-0003-3638-3114, Sterczyk, Nele, Boulekou, Sotiria, Forster, Patrycja M., Barleben, Luisa ORCID: https://orcid.org/0000-0002-0400-7117, Alzain, Nadra, Jarick, Katja J. ORCID: https://orcid.org/0000-0001-5162-7266, Pirzgalska, Roksana M., Raposo, Bruno ORCID: https://orcid.org/0000-0003-4734-7207, Hansson, Karl, Nyström, Elisabeth E.L., Gondrand, Aurelia ORCID: https://orcid.org/0009-0004-9989-4899, González-Acera, Miguel, Leclère, Pierre S. ORCID: https://orcid.org/0000-0002-1794-9461, Lapson, Marlen S., Poggenseier, Sarah ORCID: https://orcid.org/0009-0001-5343-9987, Deshpande, Divija ORCID: https://orcid.org/0000-0001-9166-2509, Velleman, Laura ORCID: https://orcid.org/0009-0002-7347-8067, Breiderhoff, Tilman ORCID: https://orcid.org/0000-0002-1676-7498, Brunkhorst, Max Felix, Schüle, Anton M. ORCID: https://orcid.org/0009-0003-3094-9778, Guerra, Gabriela M., Durek, Pawel ORCID: https://orcid.org/0000-0002-6179-0670, Mashreghi, Mir-Farzin ORCID: https://orcid.org/0000-0002-8015-6907, Kühl, Anja A. ORCID: https://orcid.org/0000-0003-2293-5387, Chu, Coco, Schneider, Christoph ORCID: https://orcid.org/0000-0002-0452-2960, Weidinger, Carl ORCID: https://orcid.org/0000-0002-9948-0088, Siegmund, Britta ORCID: https://orcid.org/0000-0002-0055-958X, Nordmann, Thierry M., Voehringer, David ORCID: https://orcid.org/0000-0001-6650-0639, Patankar, Jay V., Becker, Christoph ORCID: https://orcid.org/0000-0002-1388-1041, Birchenough, George M.H., Veiga-Fernandes, Henrique ORCID: https://orcid.org/0000-0001-6216-1836, Ronchi, Francesca, Kolesnichenko, Marina ORCID: https://orcid.org/0000-0001-7366-9061, Diefenbach, Andreas ORCID: https://orcid.org/0000-0002-9176-9530 and Klose, Christoph S.N. ORCID: https://orcid.org/0000-0001-8803-2979
Nature Immunology 26 (12): 2227-2243. December 2025

The IL-22–oncostatin M axis promotes intestinal inflammation and tumorigenesis.
Cineus, R. ORCID: https://orcid.org/0000-0003-4393-5757, Luo, Y. ORCID: https://orcid.org/0009-0003-0401-467X, Saliutina, M., Manna, S. ORCID: https://orcid.org/0000-0003-2360-0618, Cancino, C.A., Velasco Blázquez, L., Wang, L., Bösel, D., Abdelrahman, A., Klementowicz, J.E., Scherl, A., Hainbuch, S., Bréart, B., Kwon, G., Konopka, A., Guerra, G.M., von Coburg, E. ORCID: https://orcid.org/0009-0001-8546-8854, Gerbeth, Lo., Roels, J., Heinrich, F. ORCID: https://orcid.org/0000-0001-6097-5422, Müller, N. ORCID: https://orcid.org/0000-0003-1559-7711, Durek, P. ORCID: https://orcid.org/0000-0002-6179-0670, Deigendesch, N. ORCID: https://orcid.org/0000-0002-6036-3327, Ziai, J., Hung, J., Conrad, T. ORCID: https://orcid.org/0000-0001-5618-6295, Kühl, A.A. ORCID: https://orcid.org/0000-0003-2293-5387, Wirtz, S. ORCID: https://orcid.org/0000-0001-6936-7431, Löhning, M. ORCID: https://orcid.org/0000-0001-6382-7281, Keir, M. ORCID: https://orcid.org/0000-0002-0637-4092, Diefenbach, A. ORCID: https://orcid.org/0000-0002-9176-9530, Mashreghi, M.F. ORCID: https://orcid.org/0000-0002-8015-6907, Siegmund, B. ORCID: https://orcid.org/0000-0002-0055-958X, Schumann, M., Romagnani, C. ORCID: https://orcid.org/0000-0002-5167-7463, West, N.R. and Hegazy, A.N. ORCID: https://orcid.org/0000-0002-2946-8251
Nature Immunology 26 (6): 837-853. June 2025

A type 1 immunity-restricted promoter of the IL-33 receptor gene directs antiviral T-cell responses.
Brunner, T.M. ORCID: https://orcid.org/0000-0002-5279-2391, Serve, S. ORCID: https://orcid.org/0000-0002-9839-7119, Marx, A.F., Fadejeva, J., Saikali, P. ORCID: https://orcid.org/0000-0002-4916-7376, Dzamukova, M. ORCID: https://orcid.org/0000-0002-2389-3222, Durán-Hernández, N. ORCID: https://orcid.org/0000-0003-4253-0387, Kommer, C., Heinrich, F. ORCID: https://orcid.org/0000-0001-6097-5422, Durek, P., Heinz, G.A. ORCID: https://orcid.org/0000-0002-9330-3689, Höfer, T. ORCID: https://orcid.org/0000-0003-3560-8780, Mashreghi, M.F. ORCID: https://orcid.org/0000-0002-8015-6907, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Pinschewer, D.D. ORCID: https://orcid.org/0000-0002-1594-3189 and Löhning, M. ORCID: https://orcid.org/0000-0001-6382-7281
Nature Immunology 25 (2): 256-267. February 2024

GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway.
Park, A.Y. ORCID: https://orcid.org/0000-0002-0130-1521, Leney-Greene, M., Lynberg, M., Gabrielski, J.Q. ORCID: https://orcid.org/0000-0002-2953-2874, Xu, X., Schwarz, B., Zheng, L., Balasubramaniyam, A. ORCID: https://orcid.org/0000-0003-4168-8617, Ham, H. ORCID: https://orcid.org/0000-0002-8669-6875, Chao, B., Zhang, Y., Matthews, H.F., Cui, J., Yao, Y., Kubo, S. ORCID: https://orcid.org/0000-0001-9693-9263, Chanchu, J.M. ORCID: https://orcid.org/0009-0009-8024-8412, Morawski, A.R. ORCID: https://orcid.org/0000-0001-5995-0527, Cook, S.A., Jiang, P., Ravell, J.C., Cheng, Y.H., George, A., Faruqi, A. ORCID: https://orcid.org/0000-0002-4421-3767, Pagalilauan, A.M., Bergerson, J.R.E., Ganesan, S., Chauvin, S.D. ORCID: https://orcid.org/0000-0003-0232-751X, Aluri, J., Edwards-Hicks, J., Bohrnsen, E., Tippett, C., Omar, H., Xu, L., Butcher, G.W., Pascall, J., Karakoc-Aydiner, E., Kiykim, A., Maecker, H. ORCID: https://orcid.org/0000-0003-0795-9946, Tezcan, İ., Esenboga, S., Heredia, R.J., Akata, D., Tekin, S. ORCID: https://orcid.org/0000-0003-2641-6293, Kara, A. ORCID: https://orcid.org/0000-0001-7244-5031, Kuloglu, Z., Unal, E., Kendirli, T., Dogu, F., Karabiber, E., Atkinson, T.P., Cochet, C., Filhol, O. ORCID: https://orcid.org/0000-0003-1964-7958, Bosio, C.M., Davis, M.M. ORCID: https://orcid.org/0000-0001-6868-657X, Lifton, R.P., Pearce, E.L. ORCID: https://orcid.org/0000-0001-5592-5439, Daumke, O. ORCID: https://orcid.org/0000-0002-6190-1414, Aytekin, C. ORCID: https://orcid.org/0000-0002-2921-5270, Şahin, G.E., Aksu, A.Ü., Uzel, G., Koneti Rao, V. ORCID: https://orcid.org/0000-0002-7881-6902, Sari, S., Boztug, K., Cagdas, D., Haskologlu, S. ORCID: https://orcid.org/0000-0002-2668-0441, Ikinciogullari, A., Schwefel, D., Vilarinho, S., Baris, S. ORCID: https://orcid.org/0000-0002-4730-9422, Ozen, A., Su, H.C. ORCID: https://orcid.org/0000-0002-5582-9110 and Lenardo, M.J. ORCID: https://orcid.org/0000-0003-1584-468X
Nature Immunology 25 (2): 282-293. February 2024

Harnessing CD3 diversity to optimize CAR T cells.
Velasco Cárdenas, R.M.H., Brandl, S.M. ORCID: https://orcid.org/0000-0002-1632-0127, Meléndez, A.V., Schlaak, A.E., Buschky, A., Peters, T., Beier, F., Serrels, B., Taromi, S. ORCID: https://orcid.org/0000-0001-5657-6568, Raute, K., Hauri, S. ORCID: https://orcid.org/0000-0002-7249-2011, Gstaiger, M., Lassmann, S., Huppa, J.B. ORCID: https://orcid.org/0000-0003-2634-8198, Boerries, M. ORCID: https://orcid.org/0000-0002-3670-0602, Andrieux, G., Bengsch, B. ORCID: https://orcid.org/0000-0003-2552-740X, Schamel, W.W. ORCID: https://orcid.org/0000-0003-4496-3100 and Minguet, S. ORCID: https://orcid.org/0000-0001-8211-5538
Nature Immunology 24 (12): 2135-2149. December 2023

CD4(+) T cell calibration of antigen-presenting cells optimizes antiviral CD8(+) T cell immunity.
Gressier, E. ORCID: https://orcid.org/0000-0003-0517-1610, Schulte-Schrepping, J. ORCID: https://orcid.org/0000-0001-7333-8924, Petrov, L., Brumhard, S., Stubbemann, P., Hiller, A., Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Spitzer, J. ORCID: https://orcid.org/0000-0001-9696-2092, Kostevc, T., Whitney, P.G., Bachem, A., Odainic, A. ORCID: https://orcid.org/0000-0002-2806-6904, van de Sandt, C. ORCID: https://orcid.org/0000-0002-4155-7433, Nguyen, T.H.O. ORCID: https://orcid.org/0000-0002-9294-7693, Ashhurst, T. ORCID: https://orcid.org/0000-0001-7269-7773, Wilson, K. ORCID: https://orcid.org/0000-0003-2023-7964, Oates, C.V.L., Gearing, L.J. ORCID: https://orcid.org/0000-0003-3508-3056, Meischel, T. ORCID: https://orcid.org/0000-0002-0911-6574, Hochheiser, K., Greyer, M., Clarke, M., Kreutzenbeck, M., Gabriel, S.S. ORCID: https://orcid.org/0000-0002-6359-485X, Kastenmüller, W. ORCID: https://orcid.org/0000-0002-3835-1485, Kurts, C., Londrigan, S.L. ORCID: https://orcid.org/0000-0003-0989-4971, Kallies, A. ORCID: https://orcid.org/0000-0002-6312-6968, Kedzierska, K. ORCID: https://orcid.org/0000-0001-6141-335X, Hertzog, P.J., Latz, E. ORCID: https://orcid.org/0000-0003-1488-5666, Chen, Y.C.E., Radford, K.J. ORCID: https://orcid.org/0000-0001-6512-6323, Chopin, M., Schroeder, J., Kurth, Fl. ORCID: https://orcid.org/0000-0002-3807-473X, Gebhardt, T. ORCID: https://orcid.org/0000-0002-3768-9468, Sander, L.E. ORCID: https://orcid.org/0000-0002-0476-9947, Sawitzki, B., Schultze, J.L., Schmidt, S.V. and Bedoui, S. ORCID: https://orcid.org/0000-0002-7443-0543
Nature Immunology 24 (6): 979-990. June 2023

IFNγ binding to extracellular matrix prevents fatal systemic toxicity.
Kemna, J. ORCID: https://orcid.org/0000-0002-2172-4441, Gout, E. ORCID: https://orcid.org/0000-0002-5424-6474, Daniau, L., Lao, J., Weißert, K. ORCID: https://orcid.org/0000-0002-9850-6039, Ammann, S. ORCID: https://orcid.org/0000-0003-0385-1890, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Richter, M. ORCID: https://orcid.org/0000-0002-5339-0781, Molenda, C. ORCID: https://orcid.org/0000-0003-0771-405X, Sporbert, A. ORCID: https://orcid.org/0000-0002-3738-1295, Zocholl, D. ORCID: https://orcid.org/0000-0002-9218-6919, Klopfleisch, R., Schütz, A. ORCID: https://orcid.org/0000-0002-0606-2574, Lortat-Jacob, H. ORCID: https://orcid.org/0000-0002-9772-0762, Aichele, P. ORCID: https://orcid.org/0000-0002-0891-9877, Kammertoens, T. ORCID: https://orcid.org/0000-0003-3309-5141 and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Nature Immunology 24 (3): 414-422. March 2023

Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells.
Horkova, V. ORCID: https://orcid.org/0000-0002-3679-2236, Drobek, A. ORCID: https://orcid.org/0000-0003-1066-9413, Paprckova, D. ORCID: https://orcid.org/0000-0002-0151-4797, Niederlova, V. ORCID: https://orcid.org/0000-0001-8768-9039, Prasai, A., Uleri, V. ORCID: https://orcid.org/0000-0001-5040-5995, Glatzova, D., Kraller, M., Cesnekova, M., Janusova, S., Salyova, E., Tsyklauri, O. ORCID: https://orcid.org/0000-0001-9997-5913, Kadlecek, T.A., Krizova, K., Platzer, R., Schober, K., Busch, D.H. ORCID: https://orcid.org/0000-0001-8713-093X, Weiss, A., Huppa, J.B. ORCID: https://orcid.org/0000-0003-2634-8198 and Stepanek, O. ORCID: https://orcid.org/0000-0002-2735-3311
Nature Immunology 24 (1): 174-185. January 2023

Clonal expansion and epigenetic inheritance of long-lasting NK cell memory.
Rückert, T. ORCID: https://orcid.org/0000-0003-1433-1372, Lareau, C.A. ORCID: https://orcid.org/0000-0003-4179-4807, Mashreghi, M.F. ORCID: https://orcid.org/0000-0002-8015-6907, Ludwig, L.S. ORCID: https://orcid.org/0000-0002-2916-2164 and Romagnani, C. ORCID: https://orcid.org/0000-0002-5167-7463
Nature Immunology 23 (11): 1551-1563. November 2022

Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo.
Subramanian, S. ORCID: https://orcid.org/0000-0002-4917-084X, Busch, C.J.L., Molawi, K., Geirsdottir, L., Maurizio, J., Vargas Aguilar, S., Belahbib, H., Gimenez, G., Yuda, R.A.A., Burkon, M., Favret, J., Gholamhosseinian Najjar, S. ORCID: https://orcid.org/0000-0001-8457-2564, de Laval, B., Kandalla, P.K., Sarrazin, S., Alexopoulou, L. ORCID: https://orcid.org/0000-0003-4619-697X and Sieweke, M.H. ORCID: https://orcid.org/0000-0002-3228-9537
Nature Immunology 23 (3): 458-468. March 2022

Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states.
Triana, S. ORCID: https://orcid.org/0000-0003-0370-7821, Vonficht, D., Jopp-Saile, L. ORCID: https://orcid.org/0000-0002-7032-3003, Raffel, S., Lutz, R., Leonce, D., Antes, M. ORCID: https://orcid.org/0000-0001-6773-6109, Hernández-Malmierca, P. ORCID: https://orcid.org/0000-0003-4529-384X, Ordoñez-Rueda, D. ORCID: https://orcid.org/0000-0002-8387-6707, Ramasz, B., Boch, T., Jann, J.C. ORCID: https://orcid.org/0000-0003-2200-0151, Nowak, D., Hofmann, W.K., Müller-Tidow, C. ORCID: https://orcid.org/0000-0002-7166-5232, Hübschmann, D. ORCID: https://orcid.org/0000-0002-6041-7049, Alexandrov, T. ORCID: https://orcid.org/0000-0001-9464-6125, Benes, V. ORCID: https://orcid.org/0000-0002-0352-2547, Trumpp, A., Paulsen, M., Velten, L. ORCID: https://orcid.org/0000-0002-1233-5874 and Haas, S. ORCID: https://orcid.org/0000-0001-9227-2051
Nature Immunology 22 (12): 1577-1589. December 2021

Inefficient CAR-proximal signaling blunts antigen sensitivity.
Gudipati, V. ORCID: https://orcid.org/0000-0001-6647-0708, Rydzek, J., Doel-Perez, I. ORCID: https://orcid.org/0000-0003-0443-9718, Gonçalves, V.D.R. ORCID: https://orcid.org/0000-0001-9982-3346, Scharf, L. ORCID: https://orcid.org/0000-0002-1596-2208, Königsberger, S., Lobner, E. ORCID: https://orcid.org/0000-0002-5234-5524, Kunert, R. ORCID: https://orcid.org/0000-0002-3397-3621, Einsele, H., Stockinger, H. ORCID: https://orcid.org/0000-0001-6404-4430, Hudecek, M. ORCID: https://orcid.org/0000-0002-2280-2202 and Huppa, J.B. ORCID: https://orcid.org/0000-0003-2634-8198
Nature Immunology 21 (8): 848-856. August 2020

Cxcl10(+) monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation.
Giladi, A. ORCID: https://orcid.org/0000-0002-5880-2845, Wagner, L.K., Li, H., Dörr, D. ORCID: https://orcid.org/0000-0001-8575-7560, Medaglia, C., Paul, F., Shemer, A., Jung, S. ORCID: https://orcid.org/0000-0003-4290-5716, Yona, S., Mack, M., Leutz, A. ORCID: https://orcid.org/0000-0001-8259-927X, Amit, I. ORCID: https://orcid.org/0000-0003-2968-877X and Mildner, A. ORCID: https://orcid.org/0000-0002-2019-8427
Nature Immunology 21 (5): 525-534. May 2020

Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils.
Fischer, J. ORCID: https://orcid.org/0000-0003-3773-9311, Walter, C., Tönges, A., Aleth, H., Costa Jordão, M.J. ORCID: https://orcid.org/0000-0001-7888-2195, Leddin, M., Gröning, V., Erdmann, T., Lenz, G., Roth, J., Vogl, T., Prinz, M., Dugas, M., Jacobsen, I.D. ORCID: https://orcid.org/0000-0002-6033-9984 and Rosenbauer, F. ORCID: https://orcid.org/0000-0001-7977-9421
Nature Immunology 20 (5): 546-558. May 2019

TCRs are randomly distributed on the plasma membrane of resting antigen-experienced T cells.
Rossboth, B. ORCID: https://orcid.org/0000-0002-9002-9434, Arnold, A.M., Ta, H., Platzer, R., Kellner, F. ORCID: https://orcid.org/0000-0001-5931-3798, Huppa, J.B. ORCID: https://orcid.org/0000-0003-2634-8198, Brameshuber, M. ORCID: https://orcid.org/0000-0001-8672-2255, Baumgart, F. ORCID: https://orcid.org/0000-0003-1352-8632 and Schütz, G.J. ORCID: https://orcid.org/0000-0003-1542-1089
Nature Immunology 19 (8): 821-827. August 2018

Monomeric TCRs drive T cell antigen recognition.
Brameshuber, M. ORCID: https://orcid.org/0000-0001-8672-2255, Kellner, F. ORCID: https://orcid.org/0000-0001-5931-3798, Rossboth, B.K. ORCID: https://orcid.org/0000-0002-9002-9434, Ta, H., Alge, K., Sevcsik, E., Göhring, J., Axmann, M., Baumgart, F., Gascoigne, N.R.J. ORCID: https://orcid.org/0000-0001-9980-4225, Davis, S.J., Stockinger, H. ORCID: https://orcid.org/0000-0001-6404-4430, Schütz, G.J. and Huppa, J.B. ORCID: https://orcid.org/0000-0003-2634-8198
Nature Immunology 19 (5): 487-496. May 2018

c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4(+) T cells.
Gabryšová, L., Alvarez-Martinez, M., Luisier, R., Cox, L.S., Sodenkamp, J., Hosking, C., Pérez-Mazliah, D., Whicher, C., Kannan, Y., Potempa, K., Wu, X., Bhaw, L., Wende, H., Sieweke, M.H. ORCID: https://orcid.org/0000-0002-3228-9537, Elgar, G., Wilson, M., Briscoe, J., Metzis, V., Langhorne, J., Luscombe, N.M. and O'Garra, A.
Nature Immunology 19 (5): 497-507. May 2018

Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells.
Hammer, Q. ORCID: https://orcid.org/0000-0003-2968-6061, Rückert, T., Borst, E.M., Dunst, J., Haubner, A., Durek, P., Heinrich, F., Gasparoni, G., Babic, M., Tomic, A., Pietra, G. ORCID: https://orcid.org/0000-0002-7080-531X, Nienen, M., Blau, I.W., Hofmann, J., Na, I.K. ORCID: https://orcid.org/0000-0001-9902-5424, Prinz, I. ORCID: https://orcid.org/0000-0002-8789-9578, Koenecke, C. ORCID: https://orcid.org/0000-0001-7025-1735, Hemmati, P., Babel, N., Arnold, R., Walter, J., Thurley, K., Mashreghi, M.F., Messerle, M. ORCID: https://orcid.org/0000-0002-1227-3933 and Romagnani, C. ORCID: https://orcid.org/0000-0002-5167-7463
Nature Immunology 19 (5): 453-463. May 2018

Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis.
Duchene, J., Novitzky-Basso, I., Thiriot, A., Casanova-Acebes, M., Bianchini, M., Etheridge, S.L., Hub, E., Nitz, K., Artinger, K., Eller, K., Caamano, J. ORCID: https://orcid.org/0000-0003-3530-7056, Ruelicke, T. ORCID: https://orcid.org/0000-0002-2121-9496, Moss, P., Megens, R.T.A., von Andrian, U.H., Hidalgo, A. ORCID: https://orcid.org/0000-0001-5513-555X, Weber, C. and Rot, A.
Nature Immunology 18 (7): 753-761. July 2017

RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics.
Salzer, E., Cagdas, D., Hons, M., Mace, E.M., Garncarz, W., Petronczki, Ö.Y., Platzer, R., Pfajfer, L., Bilic, I., Ban, S.A., Willmann, K.L., Mukherjee, M., Supper, V., Hsu, H.T., Banerjee, P.P., Sinha, P., McClanahan, F., Zlabinger, G.J., Pickl, W.F., Gribben, J.G., Stockinger, H., Bennett, K.L., Huppa, J.B. ORCID: https://orcid.org/0000-0003-2634-8198, Dupré, L., Sanal, Ö., Jäger, U., Sixt, M., Tezcan, I., Orange, J.S. and Boztug, K.
Nature Immunology 17 (12): 1352-1360. December 2016

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.
Finkin, S., Yuan, D., Stein, I., Taniguchi, K., Weber, A., Unger, K., Browning, J.L., Goossens, N., Nakagawa, S., Gunasekaran, G., Schwartz, M.E., Kobayashi, M., Kumada, H., Berger, M., Pappo, O., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Hoshida, Y., Karin, M., Heikenwalder, M., Ben-Neriah, Y. and Pikarsky, E.
Nature Immunology 16 (12): 1235-1244. December 2015

Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor.
Grajales-Reyes, G.E., Iwata, A., Albring, J., Wu, X., Tussiwand, R., Kc, W., Kretzer, N.M., Briseno, C.G., Durai, V., Bagadia, P., Haldar, M., Schoenheit, J., Rosenbauer, F. ORCID: https://orcid.org/0000-0001-7977-9421, Murphy, T.L. and Murphy, K.M.
Nature Immunology 16 (7): 708-717. July 2015

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells.
Guy, C.S., Vignali, K.M., Temirov, J., Bettini, M.L., Overacre, A.E., Smeltzer, M., Zhang, H., Huppa, J.B. ORCID: https://orcid.org/0000-0003-2634-8198, Tsai, Y.H., Lobry, C., Xie, J., Dempsey, P.J., Crawford, H.C., Aifantis, I., Davis, M.M. and Vignali, D.A.A.
Nature Immunology 14 (3): 262-70. March 2013

Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach.
Lee, M.N., Roy, M., Ong, S.E., Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Villani, A.C., Li, W., Dotiwala, F., Sen, J., Doench, J.G., Orzalli, M.H., Kramnik, I., Knipe, D.M., Lieberman, J., Carr, S.A. and Hacohen, N.
Nature Immunology 14 (2): 179-185. February 2013

The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers.
Calado, D.P. ORCID: https://orcid.org/0000-0001-8239-7184, Sasaki, Y., Godinho, S.A., Pellerin, A., Köchert, K. ORCID: https://orcid.org/0000-0002-5548-2022, Sleckman, B.P., de Alboran, I.M., Janz, M. ORCID: https://orcid.org/0000-0002-1127-0044, Rodig, S. and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Nature Immunology 13 (11): 1092-1100. November 2012

Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC.
Xie, J., Huppa, J.B. ORCID: https://orcid.org/0000-0003-2634-8198, Newell, E.W., Huang, J., Ebert, P.J.R., Li, Q.J. and Davis, M.M.
Nature Immunology 13 (7): 674-80. July 2012

Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk.
Biton, M., Levin, A., Slyper, M., Alkalay, I., Horwitz, E., Mor, H., Kredo-Russo, S., Avnit-Sagi, T., Cojocaru, G., Zreik, F., Bentwich, Z., Poy, M.N. ORCID: https://orcid.org/0000-0002-4904-2426, Artis, D., Walker, M.D., Hornstein, E., Pikarsky, E. and Ben-Neriah, Y.
Nature Immunology 12 (3): 239-246. March 2011

The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes.
Stittrich, A.B., Haftmann, C., Sgouroudis, E., Kuehl, A.A., Hegazy, A.N., Panse, I., Riedel, R., Flossdorf, M., Dong, J., Fuhrmann, F., Heinz, G.A., Fang, Z., Li, N., Bissels, U., Hatam, F., Jahn, A., Hammoud, B., Matz, M., Schulze, F.M., Baumgrass, R., Bosio, A., Mollenkopf, H.J., Gruen, J., Thiel, A., Chen, W. ORCID: https://orcid.org/0000-0003-3263-1627, Hoefer, T., Loddenkemper, C., Loehning, M., Chang, H.D., Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332, Radbruch, A. and Mashreghi, M.F.
Nature Immunology 11 (11): 1057-1062. November 2010

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.
Lillemeier, B.F., Mörtelmaier, M.A., Forstner, M.B., Huppa, J.B. ORCID: https://orcid.org/0000-0003-2634-8198, Groves, J.T. and Davis, M.M.
Nature Immunology 11 (1): 90-96. January 2010

Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation.
van de Pavert, S.A., Olivier, B.J., Goverse, G., Vondenhoff, M.F., Greuter, M., Beke, P., Kusser, K., Höpken, U.E. ORCID: https://orcid.org/0000-0002-0776-4893, Lipp, M. ORCID: https://orcid.org/0000-0002-0087-2672, Niederreither, K., Blomhoff, R., Sitnik, K., Agace, W.W., Randall, T.D., de Jonge, W.J. and Mebius, R.E.
Nature Immunology 10 (11): 1193-1199. November 2009

Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation.
Scheller, M., Huelsken, J., Rosenbauer, F. ORCID: https://orcid.org/0000-0001-7977-9421, Taketo, M.M., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Tenen, D.G. and Leutz, A. ORCID: https://orcid.org/0000-0001-8259-927X
Nature Immunology 7 (10): 1037-1047. October 2006

Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR.
Bilic, I., Koesters, C., Unger, B., Sekimata, M., Hertweck, A., Maschek, R., Wilson, C.B. and Ellmeier, W.
Nature Immunology 7 (4): 392-400. April 2006

Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma.
Mathas, S. ORCID: https://orcid.org/0000-0001-9626-1413, Janz, M. ORCID: https://orcid.org/0000-0002-1127-0044, Hummel, F., Hummel, M., Wollert-Wulf, B. ORCID: https://orcid.org/0009-0000-0257-4049, Lusatis, S., Anagnostopoulos, I., Lietz, A., Sigvardsson, M., Jundt, F., Joehrens, K., Bommert, K., Stein, H. and Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643
Nature Immunology 7 (2): 207-215. February 2006

Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues.
Debes, G.F., Arnold, C.N., Young, A.J., Krautwald, S., Lipp, M. ORCID: https://orcid.org/0000-0002-0087-2672, Hay, J.B. and Butcher, E.C.
Nature Immunology 6 (9): 889-894. 14 August 2005

CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse.
Li, Q.J., Dinner, A.R., Qi, S., Irvine, D.J., Huppa, J.B. ORCID: https://orcid.org/0000-0003-2634-8198, Davis, M.M. and Chakraborty, A.K.
Nature Immunology 5 (8): 791-9. 1 August 2004

T cell killing does not require the formation of a stable mature immunological synapse.
Purbhoo, M.A., Irvine, D.J., Huppa, J.B. ORCID: https://orcid.org/0000-0003-2634-8198 and Davis, M.M.
Nature Immunology 5 (5): 524-530. 1 May 2004

A cis element in the recombination activating gene locus regulates gene expression by counteracting a distant silencer.
Yannoutsos, N., Barreto, V., Misulovin, Z., Gazumyan, A., Yu, W., Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332, Peixoto, B.R., Eisenreich, T. and Nussenzweig, M.C.
Nature Immunology 5 (4): 443-450. April 2004

Induced recruitment of NK cells to lymph nodes provides IFN-gamma for TH1 priming.
Martin-Fontecha, A., Thomsen, L.L., Brett, S., Gerard, C., Lipp, M. ORCID: https://orcid.org/0000-0002-0087-2672, Lanzavecchia, A. and Sallusto, F.
Nature Immunology 5 (12): 1260-1265. 1 January 2004

Continuous T cell receptor signaling required for synapse maintenance and full effector potential.
Huppa, J.B. ORCID: https://orcid.org/0000-0003-2634-8198, Gleimer, M., Sumen, C. and Davis, M.M.
Nature Immunology 4 (8): 749-55. 1 August 2003

Transcriptional profiling identifies Id2 function in dendritic cell development.
Hacker, C. ORCID: https://orcid.org/0000-0002-6545-0104, Kirsch, R.D., Ju, X.S., Hieronymus, T., Gust, T.C., Kuhl, C., Jorgas, T., Kurz, S.M., Rose-John, S., Yokota, Y. and Zenke, M.
Nature Immunology 4 (4): 380-386. April 2003

Deletion of beta-catenin impairs T cell development.
Xu, Y., Banerjee, D., Huelsken, J., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Sen, J.M.
Nature Immunology 4 (12): 1177-1182. 1 January 2003

Involvement of inhibitory NKRs in the survival of a subset of memory-phenotype CD8+ T cells.
Ugolini, S., Arpin, C., Anfossi, N., Walzer, T., Cambiaggi, A., Foerster, R., Lipp, M., Toes, R.E.M., Melief, C.J., Marvel, J. and Vivier, E.
Nature Immunology 2 (5): 430-435. 1 January 2001

Letter

A cancer immunosurveillance controversy.
Qin, Z.H. and Blankenstein, T.
Nature Immunology 5 (1): 3-4. 1 January 2004

Editorial

Trained immunity, tolerance, priming and differentiation: distinct immunological processes.
Divangahi, M. ORCID: https://orcid.org/0000-0002-1254-6110, Aaby, P.r, Khader, S.A. ORCID: https://orcid.org/0000-0002-9545-4982, Barreiro, L.B., Bekkering, S. ORCID: https://orcid.org/0000-0003-1149-466X, Chavakis, T. ORCID: https://orcid.org/0000-0002-1869-5141, van Crevel, R., Curtis, N., DiNardo, A.R., Dominguez-Andres, J. ORCID: https://orcid.org/0000-0002-9091-1961, Duivenvoorden, R., Fanucchi, S., Fayad, Z. ORCID: https://orcid.org/0000-0002-3439-7347, Fuchs, E., Hamon, M. ORCID: https://orcid.org/0000-0001-5078-4083, Jeffrey, K.L. ORCID: https://orcid.org/0000-0001-5746-0153, Khan, N., Joosten, L.A.B. ORCID: https://orcid.org/0000-0001-6166-9830, Kaufmann, E., Latz, E. ORCID: https://orcid.org/0000-0003-1488-5666, Matarese, G. ORCID: https://orcid.org/0000-0001-9429-0616, van der Meer, J.W.M., Mhlanga, M. ORCID: https://orcid.org/0000-0003-1381-3409, Moorlag, S.J.C.F.M., Mulder, W.J.M. ORCID: https://orcid.org/0000-0001-8665-3878, Naik, S., Novakovic, B., O'Neill, L. ORCID: https://orcid.org/0000-0002-4333-2748, Ochando, J. ORCID: https://orcid.org/0000-0001-7037-1681, Ozato, K., Riksen, N.P. ORCID: https://orcid.org/0000-0001-9197-8124, Sauerwein, R., Sherwood, E.R., Schlitzer, A., Schultze, J.L., Sieweke, M.H. ORCID: https://orcid.org/0000-0002-3228-9537, Benn, C.S., Stunnenberg, H., Sun, J. ORCID: https://orcid.org/0000-0001-8062-9033, van de Veerdonk, F.L. ORCID: https://orcid.org/0000-0002-1121-4894, Weis, S. ORCID: https://orcid.org/0000-0003-3201-2375, Williams, D.L., Xavier, R. ORCID: https://orcid.org/0000-0002-5630-5167 and Netea, M.G. ORCID: https://orcid.org/0000-0003-2421-6052
Nature Immunology 22 (1): 2-6. January 2021

Trained macrophages support hygiene hypothesis.
de Laval, B. and Sieweke, M.H. ORCID: https://orcid.org/0000-0002-3228-9537
Nature Immunology 18 (12): 1279-1280. 16 November 2017

Eosinophils and mast cells: a lineage apart.
Sarrazin, S. and Sieweke, M.H. ORCID: https://orcid.org/0000-0002-3228-9537
Nature Immunology 17 (6): 609-611. 19 May 2016

T. rex attacks the lysosome.
Simon, A.K. ORCID: https://orcid.org/0000-0002-4077-7995 and Ballabio, A.
Nature Immunology 14 (1): 10-2. January 2013

Lymphoid organogenesis: getting the green light from RORgammat.
Lipp, M. ORCID: https://orcid.org/0000-0002-0087-2672 and Mueller, G.
Nature Immunology 5 (1): 12-14. 1 January 2004

The final cut: how ERAP1 trims MHC ligands to size.
Falk, K. and Roetzschke, O.
Nature Immunology 3 (12): 1121-1122. December 2002