Browse by Journal Title

2023

Impaired T cell IRE1α-XBP1 signaling directs inflammation in experimental Heart Failure with Preserved Ejection Fraction.
Smolgovsky, S., Bayer, A.L., Kaur, K., Sanders, E., Aronovitz, M., Filipp, M.E., Thorp, E.B., Schiattarella, G.G., Hill, J.A., Blanton, R.M., Cubillos-Ruiz, J.R. and Alcaide, P.
Journal of Clinical Investigation 133 (24): e171874. 15 December 2023

Staring at the onco-exaptation: the two-faced medley of an ancient retrovirus, HERVH.
Singh, M., Kondraskhina, A.M., Hurst, L.D. and Izsvák, Z.
Journal of Clinical Investigation 133 (14): e172278. 17 July 2023

iPSC-derived reactive astrocytes from patients with multiple-sclerosis protect cocultured neurons in inflammatory conditions.
Kerkering, J., Muinjonov, B., Rosiewicz, K.S., Diecke, S., Biese, C., Schiweck, J., Chien, C., Zocholl, D., Conrad, T., Paul, F., Alisch, M. and Siffrin, V.
Journal of Clinical Investigation 133 (13): e164637. 3 July 2023

Patient-tailored adoptive immunotherapy with EBV-specific T cells from related and unrelated donors.
Bonifacius, A., Lamottke, B., Tischer-Zimmermann, S., Schultze-Florey, R., Goudeva, L., Heuft, H.G., Arseniev, L., Beier, R., Beutel, G., Cario, G., Fröhlich, B., Greil, J., Hansmann, L., Hasenkamp, J., Höfs, M., Hundsdoerfer, P., Jost, E., Kafa, K., Kriege, O., Kröger, N., Mathas, S., Meisel, R., Nathrath, M., Putkonen, M., Ravens, S., Reinhardt, H.C., Sala, E., Sauer, M.G, Schmitt, C., Schroers, R., Steckel, N.K., Trappe, R.U., Verbeek, M., Wolff, D., Blasczyk, R., Eiz-Vesper, B. and Maecker-Kolhoff, B.
Journal of Clinical Investigation 133 (12): e163548. 15 June 2023

Nutrient regulation of the islet epigenome controls adaptive insulin secretion.
Wortham, M., Liu, F., Harrington, A.R., Fleischman, J.Y., Wallace, M., Mulas, F., Mallick, M., Vinckier, N.K., Cross, B.R., Chiou, J., Patel, N.A., Sui, Y., McGrail, C., Jun, Y., Wang, G., Jhala, U.S., Schüle, R., Shirihai, O.S., Huising, M.O., Gaulton, K.J., Metallo, C.M. and Sander, M.
Journal of Clinical Investigation 133 (8): e165208. 17 April 2023

Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination.
Kapell, H., Fazio, L., Dyckow, J., Schwarz, S., Cruz-Herranz, A., Campos, J., Mayer, C., D Este, E., Möbius, W., Cordano, C., Pröbstel, A.K., Gharagozloo, M., Zulji, A., Narayanan Naik, V., Delank, A.K., Cerina, M., Müntefering, T., Lerma-Martin, C., Sonner, J.K., Sin, J.H., Disse, P., Rychlik, N., Sabeur, K., Chavali, M., Srivastava, R., Heidenreich, M., Fitzgerald, K.C., Seebohm, G., Stadelmann, C., Hemmer, B., Platten, M., Jentsch, T.J., Engelhardt, M., Budde, T., Nave, K.A., Calabresi, P.A., Friese, M.A., Green, A.J., Acuna, C., Rowitch, D.H., Meuth, S.G. and Schirmer, L.
Journal of Clinical Investigation 133 (7): e164223. 3 April 2023

SLC26A1 is a major determinant of sulfate homeostasis in humans.
Pfau, A., López-Cayuqueo, K.I., Scherer, N., Wuttke, M., Wernstedt, A., González Fassrainer, D., Smith, D.E., van de Kamp, J.M., Ziegeler, K., Eckardt, K.U., Luft, F.C., Aronson, P.S., Köttgen, A., Jentsch, T.J. and Knauf, F.
Journal of Clinical Investigation 133 (3): e161849. 1 February 2023

2022

Protective alpha1-antitrypsin effects in autoimmune vasculitis are compromised by methionine oxidation.
Ebert, M.J., Jerke, U., Eulenberg-Gustavus, C., Kling, L., Jenne, D.E., Kirchner, M., Mertins, P., Bieringer, M., Elitok, S., Eckardt, K.U., Schreiber, A., Salama, A.D. and Kettritz, R.
Journal of Clinical Investigation 132 (23): e160089. 1 December 2022

R-spondin-YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice.
Fischer, A.S., Müllerke, S., Arnold, A., Heuberger, J., Berger, H., Lin, M., Mollenkopf, H.J., Wizenty, J., Horst, D., Tacke, F. and Sigal, M.
Journal of Clinical Investigation 132 (21): e151363. 1 November 2022

HDAC6 modulates myofibril stiffness and diastolic function of the heart.
Lin, Y.H., Major, J.L., Liebner, T., Hourani, Z., Travers, J.G., Wennersten, S.A., Haefner, K.R., Cavasin, M.A., Wilson, C.E., Jeong, M.Y., Han, Y., Gotthardt, M., Ferguson, S.K., Ambardekar, A.V., Lam, M.P., Choudhary, C., Granzier, H.L., Woulfe, K.C. and McKinsey, T.A.
Journal of Clinical Investigation 132 (10): e148333. 16 May 2022

Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer.
Demel, U.M., Böger, M., Yousefian, S., Grunert, C., Zhang, L., Hotz, P.W., Gottschlich, A., Köse, H., Isaakidis, K., Vonficht, D., Grünschläger, F., Rohleder, E., Wagner, K., Dönig, J., Igl, V., Brzezicha, B., Baumgartner, F., Habringer, S., Löber, J., Chapuy, B., Weidinger, C., Kobold, S., Haas, S., Busse, A.B., Müller, S., Wirth, M., Schick, M. and Keller, U.
Journal of Clinical Investigation 132 (9): e152383. 2 May 2022

2020

RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models.
Haase, N., Foster, D.J., Cunningham, M.W., Bercher, J., Nguyen, T., Shulga-Morskaya, S., Milstein, S., Shaikh, S., Rollins, J., Golic, M., Herse, F., Kräker, K., Bendix, I., Serdar, M., Napieczynska, H., Heuser, A., Gellhaus, A., Thiele, K., Wallukat, G., Müller, D.N., LaMarca, B. and Dechend, R.
Journal of Clinical Investigation 130 (6): 2928-2942. 1 June 2020

2019

Chaperone protein HSC70 regulates intercellular transfer of Y chromosome antigen DBY.
Kretschmann, S., Herda, S., Bruns, H., Russ, J., van der Meijden, E.D., Schlötzer-Schrehardt, U., Griffioen, M., Na, I.K., Mackensen, A. and Kremer, A.N.
Journal of Clinical Investigation 129 (7): 2952-2963. 1 July 2019

In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia.
Wang, H., Georgakopoulou, A., Psatha, N., Li, C., Capsali, C., Samal, H.B., Anagnostopoulos, A., Ehrhardt, A., Izsvák, Z., Papayannopoulou, T., Yannaki, E. and Lieber, A.
Journal of Clinical Investigation 129 (2): 598-615. 1 February 2019

Effective NY-ESO-1-specific MHC II-restricted T cell receptors from antigen-negative hosts enhance tumor regression.
Poncette, L., Chen, X., Lorenz, F.K.M. and Blankenstein, T.
Journal of Clinical Investigation 129 (1): 324-335. 2 January 2019

2018

Mutations in multiple components of the nuclear pore complex cause nephrotic syndrome.
Braun, D.A., Lovric, S., Schapiro, D., Schneider, R., Marquez, J., Asif, M., Hussain, M.S., Daga, A., Widmeier, E., Rao, J., Ashraf, S., Tan, W., Lusk, C.P., Kolb, A., Jobst-Schwan, T., Schmidt, J.M., Hoogstraten, C.A., Eddy, K., Kitzler, T.M., Shril, S., Moawia, A., Schrage, K., Khayyat, A.I.A., Lawson, J.A., Gee, H.Y., Warejko, J.K., Hermle, T., Majmundar, A.J., Hugo, H., Budde, B., Motameny, S., Altmüller, J., Noegel, A. A., Fathy, H.M., Gale, D.P., Waseem, S.S., Khan, A., Kerecuk, L., Hashmi, S., Mohebbi, N., Ettenger, R., Serdaroğlu, E., Alhasan, K.A., Hashem, M., Goncalves, S., Ariceta, G., Ubetagoyena, M., Antonin, W., Baig, S.M., Alkuraya, F.S., Shen, Q., Xu, H., Antignac, C., Lifton, R.P., Mane, S., Nürnberg, P., Khokha, M.K. and Hildebrandt, F.
Journal of Clinical Investigation 128 (10): 4313-4328. 1 October 2018

SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling.
Voelkl, J., Luong, T.T., Tuffaha, R., Musculus, K., Auer, T., Lian, X., Daniel, C., Zickler, D., Boehme, B., Sacherer, M., Metzler, B., Kuhl, D., Gollasch, M., Amann, K., Müller, D.N., Pieske, B., Lang, F. and Alesutan, I.
Journal of Clinical Investigation 128 (7): 3024-3040. 2 July 2018

2017

S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency.
Kumar, A., Dejanovic, B., Hetsch, F., Semtner, M., Fusca, D., Arjune, S., Santamaria-Araujo, J.A., Winkelmann, A., Ayton, S., Bush, A.I., Kloppenburg, P., Meier, J.C., Schwarz, G. and Belaidi, A.A.
Journal of Clinical Investigation 127 (12): 4365-4378. 1 December 2017

Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells.
Nieborowska-Skorska, M., Sullivan, K., Dasgupta, Y., Podszywalow-Bartnicka, P., Hoser, G., Maifrede, S., Martinez, E., Di Marcantonio, D., Bolton-Gillespie, E., Cramer-Morales, K., Lee, J., Li, M., Slupianek, A., Gritsyuk, D., Cerny-Reiterer, S., Seferynska, I., Stoklosa, T., Bullinger, L., Zhao, H., Gorbunova, V., Piwocka, K., Valent, P., Civin, C.I., Muschen, M., Dick, J.E., Wang, J.C., Bhatia, S., Bhatia, R., Eppert, K., Minden, M.D., Sykes, S.M. and Skorski, T.
Journal of Clinical Investigation 127 (6): 2392-2406. 1 June 2017

Somatic mutations and progressive monosomy modify SAMD9-related phenotypes in humans.
Buonocore, F., Kuehnen, P., Suntharalingham, J.P., Del Valle, I., Digweed, M., Stachelscheid, H., Khajavi, N., Didi, M., Brady, A.F., Blankenstein, O., Procter, A.M., Dimitri, P., Wales, J.K.H., Ghirri, P., Knoebl, D., Strahm, B., Erlacher, M., Wlodarski, M.W., Chen, W., Kokai, G.K., Anderson, G., Morrogh, D., Moulding, D.A., McKee, S. A., Niemeyer, C.M., Grueters, A. and Achermann, J.C.
Journal of Clinical Investigation 127 (5): 1700-1713. 1 May 2017

High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation.
Kitada, K., Daub, S., Zhang, Y., Klein, J. D., Nakano, D., Pedchenko, T., Lantier, L., LaRocque, L.M., Marton, A., Neubert, P., Schröder, A., Rakova, N., Jantsch, J., Dikalova, A.E., Dikalov, S.I., Harrison, D.G., Müller, D.N., Nishiyama, A., Rauh, M., Harris, R. C., Luft, F.C., Wassermann, D.H., Sands, J.M. and Titze, J.
Journal of Clinical Investigation 127 (5): 1944-1959. 1 May 2017

Increased salt consumption induces body water conservation and decreases fluid intake.
Rakova, N., Kitada, K., Lerchl, K., Dahlmann, A., Birukov, A., Daub, S., Kopp, C., Pedchenko, T., Zhang, Y., Beck, L., Johannes, B., Marton, A., Müller, D.N., Rauh, M., Luft, F.C. and Titze, J.
Journal of Clinical Investigation 127 (5): 1932-1943. 1 May 2017

Mutations in γ-secretase subunit-encoding PSENEN underlie Dowling-Degos disease associated with acne inversa.
Ralser, D.J., Basmanav, F.B.Ü., Tafazzoli, A., Wititsuwannakul, J., Delker, S., Danda, S., Thiele, H., Wolf, S., Busch, M., Pulimood, S.A., Altmüller, J., Nürnberg, P., Lacombe, D., Hillen, U., Wenzel, J., Frank, J., Odermatt, B. and Betz, R.C.
Journal of Clinical Investigation 127 (4): 1485-1490. 3 April 2017

LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells.
Ediger, B.N., Lim, H.W., Juliana, C., Groff, D.N., Williams, L.T., Dominguez, G., Liu, J.H., Taylor, B.L., Walp, E.R., Kameswaran, V., Yang, J., Liu, C., Hunter, C.S., Kaestner, K.H., Naji, A., Li, C., Sander, M., Stein, R., Sussel, L., Won, K.J., May, C.L. and Stoffers, D.A.
Journal of Clinical Investigation 127 (1): 215-229. 3 January 2017

2016

Advances in β cell replacement and regeneration strategies for treating diabetes.
Benthuysen, J.R., Carrano, A.C. and Sander, M.
Journal of Clinical Investigation 126 (10): 3651-3660. 3 October 2016

Axial tubule junctions control rapid calcium signaling in atria.
Brandenburg, S., Kohl, T., Williams, G.S.B., Gusev, K., Wagner, E., Rog-Zielinska, E.A., Hebisch, E., Dura, M., Didié, M., Gotthardt, M., Nikolaev, V.O., Hasenfuss, G., Kohl, P., Ward, C.W., Lederer, W.J. and Lehnart, S.E.
Journal of Clinical Investigation 126 (10): 3999-4015. 3 October 2016

SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.
Schmidt, V., Schulz, N., Yan, X., Schürmann, A., Kempa, S., Kern, M., Blüher, M., Poy, M.N., Olivecrona, G. and Willnow, T.E.
Journal of Clinical Investigation 126 (7): 2706-2720. 1 July 2016

Targeting human melanoma neoantigens by T cell receptor gene therapy.
Leisegang, M., Kammertoens, T., Uckert, W. and Blankenstein, T.
Journal of Clinical Investigation 126 (3): 854-858. 1 March 2016

2015

High salt reduces the activation of IL-4- and IL-13-stimulated macrophages.
Binger, K.J., Gebhardt, M., Heinig, M., Rintisch, C., Schroeder, A., Neuhofer, W., Hilgers, K., Manzel, A., Schwartz, C., Kleinewietfeld, M., Voelkl, J., Schatz, V., Linker, R.A., Lang, F., Voehringer, D., Wright, M.D., Hubner, N., Dechend, R., Jantsch, J., Titze, J. and Müller, D.N.
Journal of Clinical Investigation 125 (11): 4223-4238. 2 November 2015

Lineage fate of ductular reactions in liver injury and carcinogenesis.
Jörs, S., Jeliazkova, P., Ringelhan, M., Thalhammer, J., Dürl, S., Ferrer, J., Sander, M., Heikenwalder, M., Schmid, R.M., Siveke, J.T. and Geisler, F.
Journal of Clinical Investigation 125 (6): 2445-57. 1 June 2015

X-linked macrocytic dyserythropoietic anemia in females with an ALAS2 mutation.
Sankaran, V.G., Ulirsch, J.C., Tchaikovskii, V., Ludwig, L.S., Wakabayashi, A., Kadirvel, S., Lindsley, R.C., Bejar, R., Shi, J., Lovitch, S.B., Bishop, D.F. and Steensma, D.P.
Journal of Clinical Investigation 125 (4): 1665-1669. 1 April 2015

MHCII-independent CD4(+) T cells protect injured CNS neurons via IL-4.
Walsh, J.T., Hendrix, S., Boato, F., Smirnov, I., Zheng, J., Lukens, J.R., Gadani, S., Hechler, D., Gölz, G., Rosenberger, K., Kammertöns, T., Vogt, J., Vogelaar, C., Siffrin, V., Radjavi, A., Fernandez-Castaneda, A., Gaultier, A., Gold, R., Kanneganti, T.D., Nitsch, R., Zipp, F. and Kipnis, J.
Journal of Clinical Investigation 125 (2): 699-714. 2 February 2015

Defective removal of ribonucleotides from DNA promotes systemic autoimmunity.
Günther, C., Kind, B., Reijns, M.A.M., Berndt, N., Martinez-Bueno, M., Wolf, C., Tüngler, V., Chara, O., Lee, Y.A., Hübner, N., Bicknell, L., Blum, S., Krug, C., Schmidt, F., Kretschmer, S., Koss, S., Astell, K.R., Ramantani, G., Bauerfeind, A., Morris, D.L., Cunninghame Graham, D.S., Bubeck, D., Leitch, A., Ralston, S.H., Blackburn, E.A., Gahr, M., Witte, T., Vyse, T.J., Melchers, I., Mangold, E., Nöthen, M.M., Aringer, M., Kuhn, A., Lüthke, K., Unger, L., Bley, A., Lorenzi, A., Isaacs, J.D., Alexopoulou, D., Conrad, K., Dahl, A., Roers, A., Alarcon-Riquelme, M.E., Jackson, A.P. and Lee-Kirsch, M.A.
Journal of Clinical Investigation 125 (1): 413-424. 2 January 2015

2014

GP130 activation induces myeloma and collaborates with MYC.
Dechow, T., Steidle, S., Götze, K.S., Rudelius, M., Behnke, K., Pechloff, K., Kratzat, S., Bullinger, L., Fend, F., Soberon, V., Mitova, N., Li, Z., Thaler, M., Bauer, J., Pietschmann, E., Albers, C., Grundler, R., Schmidt-Supprian, M., Ruland, J., Peschel, C., Duyster, J., Rose-John, S., Bassermann, F. and Keller, U.
Journal of Clinical Investigation 124 (12): 5263-5274. 1 December 2014

Human satellite cells have regenerative capacity and are genetically manipulable.
Marg, A., Escobar, H., Gloy, S., Kufeld, M., Zacher, J., Spuler, A., Birchmeier, C., Izsvák, Z. and Spuler, S.
Journal of Clinical Investigation 124 (10): 4257-4265. 1 October 2014

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8(+) T cells.
Henson, S.M., Lanna, A., Riddell, N.E., Franzese, O., Macaulay, R., Griffiths, S.J., Puleston, D.J., Watson, A.S., Simon, A.K., Tooze, S.A. and Akbar, A.N.
Journal of Clinical Investigation 124 (9): 4004-4016. 2 September 2014

RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing.
Maatz, H., Jens, M., Liss, M., Schafer, S., Heinig, M., Kirchner, M., Adami, E., Rintisch, C., Dauksaite, V., Radke, M.H., Selbach, M., Barton, P.J.R., Cook, S.A., Rajewsky, N., Gotthardt, M., Landthaler, M. and Hubner, N.
Journal of Clinical Investigation 124 (8): 3419-3430. 1 August 2014

α-intercalated cells defend the urinary system from bacterial infection.
Paragas, N., Kulkarni, R., Werth, M., Schmidt-Ott, K.M., Forster, C., Deng, R., Zhang, Q., Singer, E., Klose, A.D., Shen, T.H., Francis, K.P., Ray, S., Vijayakumar, S., Seward, S., Bovino, M.E., Xu, K., Takabe, Y., Amaral, F.E., Mohan, S., Wax, R., Corbin, K., Sanna-Cherchi, S., Mori, K., Johnson, L., Nickolas, T., D’Agati, V., Lin, C.S., Qiu, A., Al-Awqati, Q., Ratner, A.J. and Barasch, J.
Journal of Clinical Investigation 124 (7): 2963-2976. 1 July 2014

TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction.
Ragancokova, D., Rocca, E., Oonk, A.M.M., Schulz, H., Rohde, E., Bednarsch, J., Feenstra, I., Pennings, R.J.E., Wende, H. and Garratt, A.N.
Journal of Clinical Investigation 124 (3): 1214-1227. 3 March 2014

Disruption of vascular Ca2+-activated chloride currents lowers blood pressure.
Heinze, C., Seniuk, A., Sokolov, M.V., Huebner, A.K., Klementowicz, A.E., Szijártó, I.A., Schleifenbaum, J., Vitzthum, H., Gollasch, M., Ehmke, H., Schroeder, B.C. and Hübner, C.A.
Journal of Clinical Investigation 124 (2): 675-686. 3 February 2014

Changes in neural network homeostasis trigger neuropsychiatric symptoms.
Winkelmann, A., Maggio, N., Eller, J., Caliskan, G., Semtner, M., Häussler, U., Jüttner, R., Dugladze, T., Smolinsky, B., Kowalczyk, S., Chronowska, E., Schwarz, G., Rathjen, F.G., Rechavi, G., Haas, C.A., Kulik, A., Gloveli, T., Heinemann, U. and Meier, J.C.
Journal of Clinical Investigation 124 (2): 696-711. 3 February 2014

2013

Inactivation of specific β cell transcription factors in type 2 diabetes.
Guo, S., Dai, C., Guo, M., Taylor, B., Harmon, J.S., Sander, M., Robertson, R.P., Powers, A.C. and Stein, R.
Journal of Clinical Investigation 123 (8): 3305-16. August 2013

Immune cells control skin lymphatic electrolyte homeostasis and blood pressure.
Wiig, H., Schröder, A., Neuhofer, W., Jantsch, J., Kopp, C., Karlsen, T.V., Boschmann, M., Goss, J., Bry, M., Rakova, N., Dahlmann, A., Brenner, S., Tenstad, O., Nurmi, H., Mervaala, E., Wagner, H., Beck, F.X., Müller, D.N., Kerjaschki, D., Luft, F.C., Harrison, D.G., Alitalo, K. and Titze, J.
Journal of Clinical Investigation 123 (7): 2803-2815. 1 July 2013

CXCL5 limits macrophage foam cell formation in atherosclerosis.
Rousselle, A., Qadri, F., Leukel, L., Yilmaz, R., Fontaine, J.F., Sihn, G., Bader, M., Ahluwalia, A. and Duchene, J.
Journal of Clinical Investigation 123 (3): 1343-1347. 1 March 2013

Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance.
Willimsky, G., Schmidt, K., Loddenkemper, C., Gellermann, J. and Blankenstein, T.
Journal of Clinical Investigation 123 (3): 1032-1043. 1 March 2013

2012

A misplaced lncRNA causes brachydactyly in humans.
Maass, P.G., Rump, A., Schulz, H., Stricker, S., Schulze, L., Platzer, K., Aydin, A., Tinschert, S., Goldring, M.B., Luft, F.C. and Bähring, S.
Journal of Clinical Investigation 122 (11): 3990-4002. 1 November 2012

2011

Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice.
Gangadharan, V., Wang, R., Ulzhoefer, B., Luo, C., Bardoni, R., Bali, K.K., Agarwal, N., Tegeder, I., Hildebrandt, U., Nagy, G.G., Todd, A.J., Ghirri, A., Haeussler, A., Sprengel, R., Seeburg, P.H., Macdermott, A.B., Lewin, G.R. and Kuner, R.
Journal of Clinical Investigation 121 (4): 1608-1623. 1 April 2011

2010

MHC-restricted fratricide of human lymphocytes expressing survivin-specific transgenic T cell receptors.
Leisegang, M., Wilde, S., Spranger, S., Milosevic, S., Frankenberger, B., Uckert, W. and Schendel, D.J.
Journal of Clinical Investigation 120 (11): 3869-3877. 1 November 2010

Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease.
Joutel, A., Monet-Lepretre, M., Gosele, C., Baron-Menguy, C., Hammes, A., Schmidt, S., Lemaire-Carrette, B., Domenga, V., Schedl, A., Lacombe, P. and Huebner, N.
Journal of Clinical Investigation 120 (2): 433-445. 1 February 2010

The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease.
Na, I.K., Lu, S.X., Yim, N.L., Goldberg, G.L., Tsai, J., Rao, U., Smith, O.M., King, C.G., Suh, D., Hirschhorn-Cymerman, D., Palomba, L., Penack, O., Holland, A.M., Jenq, R.R., Ghosh, A., Tran, H., Merghoub, T., Liu, C., Sempowski, G.D., Ventevogel, M., Beauchemin, N. and van den Brink, M.R.M.
Journal of Clinical Investigation 120 (1): 343-356. January 2010

2009

The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.
Rueder, C., Höpken, U.E., Wolf, J., Mittruecker, H.W., Engels, B., Erdmann, B., Wollenzin, S., Uckert, W., Dörken, B. and Rehm, A.
Journal of Clinical Investigation 119 (8): 2184-2203. August 2009

Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation.
Huck, K., Feyen, O., Niehues, T., Rueschendorf, F., Huebner, N., Laws, H.J., Telieps, T., Knapp, S., Wacker, H.H., Meindl, A., Jumaa, H. and Borkhardt, A.
Journal of Clinical Investigation 119 (5): 1350-1358. May 2009

2008

Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice.
Fu, J., Gerhardt, H., McDaniel, J.M., Xia, B., Liu, X., Ivanciu, L., Ny, A., Hermans, K., Silasi-Mansat, R., McGee, S., Nye, E., Ju, T., Ramirez, M.I., Carmeliet, P., Cummings, R.D., Lupu, F. and Xia, L.
Journal of Clinical Investigation 118 (11): 3725-3737. November 2008

2007

A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.
Steidl, U., Steidl, C., Ebralidze, A., Chapuy, B., Han, H.J., Will, B., Rosenbauer, F., Becker, A., Wagner, K., Koschmieder, S., Kobayashi, S., Costa, D.B., Schulz, T., OBrien, K.B., Verhaak, R.G.W., Delwel, R., Haase, D., Truemper, L., Krauter, J., Kohwi-Shigematsu, T., Griesinger, F. and Tenen, D.G.
Journal of Clinical Investigation 117 (9): 2611-2620. 4 September 2007

Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3.
Fielitz, J., Kim, M.S., Shelton, J.M., Latif, S., Spencer, J.A., Glass, D.J., Richardson, J.A., Bassel-Duby, R. and Olson, E.N.
Journal of Clinical Investigation 117 (9): 2486-2495. September 2007

TRAIL limits excessive host immune responses in bacterial meningitis.
Hoffmann, O., Priller, J., Prozorovski, T., Schulze-Topphoff, U., Baeva, N., Lunemann, J.D., Aktas, O., Mahrhofer, C., Stricker, S., Zipp, F. and Weber, J.R.
Journal of Clinical Investigation 117 (7): 2004-2013. 2 July 2007

Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice.
Rust, M.B., Alper, S.L., Rudhard, Y., Shmukler, B.E., Vicente, R., Brugnara, C., Trudel, M., Jentsch, T.J. and Huebner, C.A.
Journal of Clinical Investigation 117 (6): 1708-1717. 1 June 2007

2006

Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis.
Visekruna, A., Joeris, T., Seidel, D., Kroesen, A., Loddenkemper, C., Zeitz, M., Kaufmann, S.H.E., Schmidt-Ullrich, R. and Steinhoff, U.
Journal of Clinical Investigation 116 (12): 3195-3203. December 2006

Arrhythmogenic right ventricular cardiomyopathy: moving toward mechanism.
MacRae, C.A., Birchmeier, W. and Thierfelder, L.
Journal of Clinical Investigation 116 (7): 1825-1828. July 2006

Pericytes limit tumor cell metastasis.
Xian, X., Håkansson, J., Ståhlberg, A., Lindblom, P., Betsholtz, C., Gerhardt, H. and Semb, H.
Journal of Clinical Investigation 116 (3): 642-651. 1 March 2006

2005

Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization.
Potente, M., Urbich, C., Sasaki, K.I., Hofmann, W.K., Heeschen, C., Aicher, A., Kollipara, R., DePinho, R.A., Zeiher, A.M. and Dimmeler, S.
Journal of Clinical Investigation 115 (9): 2382-2392. 1 September 2005

Chloride channel diseases resulting from impaired transepithelial transport or vesicular function.
Jentsch, T.J., Maritzen, T. and Zdebik, A.A.
Journal of Clinical Investigation 115 (8): 2039-2046. August 2005

Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury.
Mori, K., Lee, H.T., Rapoport, D., Drexler, I.R., Foster, K., Yang, J., Schmidt-Ott, K.M., Chen, X., Li, J.Y., Weiss, S., Mishra, J., Cheema, F.H., Markowitz, G., Suganami, T., Sawai, K., Mukoyama, M., Kunis, C., D'Agati, V., Devarajan, P. and Barasch, J.
Journal of Clinical Investigation 115 (3): 610-621. March 2005

2004

Cellular senescence in cancer treatment: friend or foe?
Kahlem, P., Doerken, B. and Schmitt, C.A.
Journal of Clinical Investigation 113 (2): 169-174. January 2004

2002

In vivo bradykinin B2 receptor activation reduces renal fibrosis.
Schanstra, J.P., Neau, E., Drogoz, P., Gomez, M.A.A., Novoa, J.M.L., Calise, D., Pecher, C., Bader, M., Girolami, J.P. and Bascands, J.L.
Journal of Clinical Investigation 110 (3): 371-379. 1 August 2002

2001

Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity.
Holst, P.J., Rosenkilde, M.M., Manfra, D., Chen, S.C., Wiekowski, M.T., Holst, B., Cifire, F., Lipp, M., Schwartz, T.W. and Lira, S.A.
Journal of Clinical Investigation 108 (12): 1789-1796. December 2001

2000

Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP.
Kaufmann, J.E., Oksche, A., Wollheim, C.B., Guenther, G., Rosenthal, W. and Vischer, U.M.
Journal of Clinical Investigation 106 (1): 107-116. July 2000

Cubilin is an albumin binding protein important for renal tubular albumin reabsorption.
Birn, H., Fyfe, J.C., Jacobsen, C., Mounier, F., Verroust, P.J., Orskov, H., Willnow, T.E., Moestrup, S.K. and Christensen, E.I.
Journal of Clinical Investigation 105 (10): 1353-1361. May 2000

1999

Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor.
Wallukat, G., Homuth, V., Fischer, T., Lindschau, C., Horstkamp, B., Jupner, A., Baur, E., Nissen, E., Vetter, K., Neichel, D., Dudenhausen, J.W., Haller, H. and Luft, F.C.
Journal of Clinical Investigation 103 (7): 945-952. 1 April 1999

1998

beta(2)-glycoprotein-1 (apolipoprotein H) and beta(2)-glycoprotein-1-phospholipid complex harbor a recognition site for the endocytic receptor megalin.
Moestrup, S.K., Schousboe, I., Jacobsen, C., Leheste, J.R., Christensen, E.I. and Willnow, T.E.
Journal of Clinical Investigation 102 (5): 902-909. 1 September 1998

The B1-agonist [des-Arg10]-kallidin activates transcription factor NF-kappaB and induces homologous upregulation of the bradykinin B1-receptor in cultured human lung fibroblasts.
Schanstra, J.P., Bataille, E., Castano, M.E.M., Barascud, Y., Hirtz, C., Pesquero, J.B., Pecher, C., Gauthier, F., Girolami, J.P. and Bascands, J.L.
Journal of Clinical Investigation 101 (10): 2080-2091. 15 May 1998

Vasoactive intestinal peptide, forskolin, and genistein increase apical CFTR trafficking in the rectal gland of the spiny dogfish, Squalus acanthias. Acute regulation of CFTR trafficking in an intact epithelium.
Lehrich, R.W., Aller, S.G., Webster, P., Marino, C.R. and Forrest, J.N. .J.r.
Journal of Clinical Investigation 101 (4): 737-745. 15 February 1998

Inducible inactivation of hepatic LRP gene by Cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants.
Rohlmann, A., Gotthardt, M., Hammer, R.E. and Herz, J.
Journal of Clinical Investigation 101 (3): 689-695. 1 February 1998

Angiotensinogen gene and hypertension in Chinese.
Niu, T.H., Xu, X.P., Rogus, J., Zhou, Y.S., Chen, C.Z., Yang, J.H., Fang, Z., Schmitz, C., Zhao, J.H., Rao, V.S. and Lindpaintner, K.
Journal of Clinical Investigation 101 (1): 188-194. 1 January 1998

1997

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.
Bargou, R.C., Emmerich, F., Krappmann, D., Bommert, K., Mapara, M.Y., Arnold, W., Royer, H.D., Grinstein, E., Greiner, A., Scheidereit, C. and Doerken, B.
Journal of Clinical Investigation 100 (12): 2961-2969. 15 December 1997

Tissue and development specific expression of multiple alternatively spliced transcripts of rat neuronal nitric oxide synthase.
Lee, M.A., Cai, L., Hübner, N., Lee, Y.A. and Lindpaintner, K.
Journal of Clinical Investigation 100 (6): 1507-1512. 15 September 1997

Reconstitution of mutant V2 vasopressin receptors by adenovirus mediated gene transfer. Molecular basis and clinical implication.
Schoeneberg, T., Sandig, V., Wess, J., Gudermann, T. and Schultz, G.
Journal of Clinical Investigation 100 (6): 1547-1556. 15 September 1997

Identification of a cis-acting regulatory element conferring inducibility of the atrial natriuretic factor gene in acute pressure overload.
von Harsdorf, R., Edwards, J.G., Shen, Y.T., Kudej, R.K., Dietz, R., Leinwand, L.A., Nadal-Ginard, B. and Vatner, S.F.
Journal of Clinical Investigation 100 (5): 1294-1304. 1 September 1997

Novel splice donor site mutation in the cardiac myosin binding protein-C gene in familial hypertrophic cardiomyopathy: characterization of cardiac transcript and protein.
Rottbauer, W., Gautel, M., Zehelein, J., Labeit, S., Franz, W.M., Fischer, C., Vollrath, B., Mall, G., Dietz, R., Kuebler, W. and Katus, H.A.
Journal of Clinical Investigation 100 (2): 475-482. 15 July 1997

Idiopathic low molecular weight proteinuria associated with hypercalciuric nephrocalcinosis in Japanese children is due to mutations of the renal chloride channel (CLCN5).
Lloyd, S.E., Pearce, S.H., Guenther, W., Kawaguchi, H., Igarashi, T., Jentsch, T.J. and Thakker, R.V.
Journal of Clinical Investigation 99 (5): 967-974. 1 March 1997

1996

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.
Berg, D.J., Davidson, N., Kühn, R., Müller, W., Menon, S., Holland, G., Thompson-Snipes, L., Leach, M.W. and Rennick, D.
Journal of Clinical Investigation 98 (4): 1010-1020. 15 August 1996

Conditional gene targeting.
Rajewsky, K., Gu, H., Kühn, R., Betz, U.A., Müller, W., Roes, J. and Schwenk, F.
Journal of Clinical Investigation 98 (3): 600-603. 1 August 1996

Regulation of human heart contractility by essential myosin light chain isoforms.
Morano, M., Zacharzowski, U., Maier, M., Lange, P.E., Alexi-Meskishvili, V., Haase, H. and Morano, I.
Journal of Clinical Investigation 98 (2): 467-473. 15 July 1996

Association and cosegregation of stroke with impaired edothelium-dependent vasorelaxation in stroke prone, spontaneously hypertensive rats.
Volpe, M., Iaccarino, G., Vecchione, C., Rizzoni, D., Russo, R., Rubattu, S., Condorelli, G., Ganten, U., Ganten, D., Trimarco, B. and Lindpaintner, K.
Journal of Clinical Investigation 98 (2): 256-261. 15 July 1996

Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice.
Bargou, R.C., Wagener, C., Bommert, K., Mapara, M.Y., Daniel, P.T., Arnold, W., Dietel, M., Guski, H., Feller, A., Royer, H.D. and Doerken, B.
Journal of Clinical Investigation 97 (11): 2651-2659. 1 June 1996

1995

Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.
Berg, D.J., Kühn, R., Rajewsky, K., Müller, W., Menon, S., Davidson, N., Grünig, G. and Rennick, D.
Journal of Clinical Investigation 96 (5): 2339-2347. November 1995

Familial hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome maps to a locus on chromosome 7q3.
MacRae, C.A., Ghaisas, N., Kass, S., Donnelly, S., Basson, C.T., Watkins, H.C., Anan, R., Thierfelder, L.H., McGarry, K., Rowland, E., McKenna, W.J., Seidman, J.G. and Seidman, C.E.
Journal of Clinical Investigation 96 (3): 1216-1220. September 1995

The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells.
Stoll, M., Steckelings, U.M., Paul, M., Bottari, S.P., Metzger, R. and Unger, T.
Journal of Clinical Investigation 95 (2): 651-657. February 1995

1994

C/EBP beta regulation of the tumor necrosis factor alpha gene.
Pope, R.M., Leutz, A. and Ness, S.A.
Journal of Clinical Investigation 94 (4): 1449-1455. October 1994

Augmented agonist induced Ca2+-sensitization of coronary artery contraction in genetically hypertensive rats - evidence for altered signal transduction in the coronary smooth muscle cells.
Satoh, S., Kreutz, R., Wilm, C., Ganten, D. and Pfitzer, G.
Journal of Clinical Investigation 94 (4): 1397-1403. October 1994

Gene expression, localization, and characterization of endothelin A and B receptors in the human adrenal cortex.
Rossi, G.P., Albertin, G., Belloni, A., Zanin, L., Biasolo, M.A., Prayer-Galetti, T., Bader, M., Nussdorfer, G.G., Palu, G. and Pessina, A.C.
Journal of Clinical Investigation 94 (3): 1226-1234. September 1994

Prognostic implications of novel beta cardiac myosin heavy chain gene mutations that cause familial hypertrophic cardiomyopathy.
Anan, R., Greve, G., Thierfelder, L.H., Watkins, H., McKenna, W.J., Solomon, S., Vecchio, C., Shono, H., Nakao, S. and Tanaka, H.
Journal of Clinical Investigation 93 (1): 280-285. January 1994

1993

Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones.
Meinl, E., Weber, F., Drexler, K., Morelle, C., Ott, M., Saruhan-Direskeneli, G., Goebels, N., Ertl, B., Jechart, G., Giegerich, G., Schoenbeck, S., Bannwarth, W., Wekerle, H. and Hohlfeld, R.
Journal of Clinical Investigation 92 (6): 2633-2643. December 1993

X-linked nephrogenic diabetes insipidus mutations in North America and the Hopewell hypothesis.
Bichet, D.G., Arthus, M.F., Lonergan, M., Hendy, G.N., Paradis, A.J., Fujiwara, T.M., Morgan, K., Gregory, M.C., Rosenthal, W. and Didwania, A.
Journal of Clinical Investigation 92 (3): 1262-1268. September 1993

A circulating substance cross-reacting with antiimidazoline antibodies.
Dontenwill, M., Molines, A., Verdun, A., Bricca, G., Laurent, S. and Bousquet, P.
Journal of Clinical Investigation 92 (2): 1068-1072. August 1993

Na+/H+ exchange in human lymphocytes and platelets in chronic and subacute metabolic acidosis.
Reusch, H.P., Reusch, R., Rosskopf, D., Siffert, W., Mann, J.F. and Luft, F.C.
Journal of Clinical Investigation 92 (2): 858-865. August 1993

Cellular localization and regional distribution of an angiotensin II-forming chymase in the heart.
Urata, H., Boehm, K.D., Philip, A., Kinoshita, A., Gabrovsek, J., Bumpus, F.M. and Husain, A.
Journal of Clinical Investigation 91 (4): 1269-1281. April 1993

Increased adrenal renin in transgenic hypertensive rats, TGR(mREN2)27, and its regulation by cAMP, angiotensin II and calcium.
Peters, J., Muenter, K., Bader, M., Hackenthal, E., Mullins, J.J. and Ganten, D.
Journal of Clinical Investigation 91 (3): 742-747. March 1993

1992

Sporadic hypertrophic cardiomyopathy due to de novo myosin mutations.
Watkins, H., Thierfelder, L., Hwang, D.S., McKenna, W., Seidman, J.G. and Seidman, C.E.
Journal of Clinical Investigation 90 (5): 1666-1671. November 1992

Transplantation of thymic autoimmune microenvironment to severe combined immunodeficiency mice. A new model of myasthenia gravis.
Schoenbeck, S., Padberg, F., Hohlfeld, R. and Wekerle, H.
Journal of Clinical Investigation 90 (1): 245-250. July 1992