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2018

SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling.
Voelkl, J. and Luong, T.T. and Tuffaha, R. and Musculus, K. and Auer, T. and Lian, X. and Daniel, C. and Zickler, D. and Boehme, B. and Sacherer, M. and Metzler, B. and Kuhl, D. and Gollasch, M. and Amann, K. and Müller, D.N. and Pieske, B. and Lang, F. and Alesutan, I.
Journal of Clinical Investigation 128 (7): 3024-3040. 2 July 2018

2017

S-sulfocysteine/NMDA receptor-dependentsignaling underlies neurodegeneration in molybdenum cofactor deficiency.
Kumar, A. and Dejanovic, B. and Hetsch, F. and Semtner, M. and Fusca, D. and Arjune, S. and Santamaria-Araujo, J.A. and Winkelmann, A. and Ayton, S. and Bush, A.I. and Kloppenburg, P. and Meier, J.C. and Schwarz, G. and Belaidi, A.A.
Journal of Clinical Investigation 127 (12): 4365-4378. 1 December 2017

Somatic mutations and progressive monosomy modify SAMD9-related phenotypes in humans.
Buonocore, F. and Kuehnen, P. and Suntharalingham, J.P. and Del Valle, I. and Digweed, M. and Stachelscheid, H. and Khajavi, N. and Didi, M. and Brady, A.F. and Blankenstein, O. and Procter, A.M. and Dimitri, P. and Wales, J.K.H. and Ghirri, P. and Knoebl, D. and Strahm, B. and Erlacher, M. and Wlodarski, M.W. and Chen, W. and Kokai, G.K. and Anderson, G. and Morrogh, D. and Moulding, D.A. and McKee, S. A. and Niemeyer, C.M. and Grueters, A. and Achermann, J.C.
Journal of Clinical Investigation 127 (5): 1700-1713. 1 May 2017

High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation.
Kitada, K. and Daub, S. and Zhang, Y. and Klein, J. D. and Nakano, D. and Pedchenko, T. and Lantier, L. and LaRocque, L.M. and Marton, A. and Neubert, P. and Schröder, A. and Rakova, N. and Jantsch, J. and Dikalova, A.E. and Dikalov, S.I. and Harrison, D.G. and Müller, D.N. and Nishiyama, A. and Rauh, M. and Harris, R. C. and Luft, F.C. and Wassermann, D.H. and Sands, J.M. and Titze, J.
Journal of Clinical Investigation 127 (5): 1944-1959. 1 May 2017

Increased salt consumption induces body water conservation and decreases fluid intake.
Rakova, N. and Kitada, K. and Lerchl, K. and Dahlmann, A. and Birukov, A. and Daub, S. and Kopp, C. and Pedchenko, T. and Zhang, Y. and Beck, L. and Johannes, B. and Marton, A. and Müller, D.N. and Rauh, M. and Luft, F.C. and Titze, J.
Journal of Clinical Investigation 127 (5): 1932-1943. 1 May 2017

2016

Axial tubule junctions control rapid calcium signaling in atria.
Brandenburg, S. and Kohl, T. and Williams, G.S.B. and Gusev, K. and Wagner, E. and Rog-Zielinska, E.A. and Hebisch, E. and Dura, M. and Didié, M. and Gotthardt, M. and Nikolaev, V.O. and Hasenfuss, G. and Kohl, P. and Ward, C.W. and Lederer, W.J. and Lehnart, S.E.
Journal of Clinical Investigation 126 (10): 3999-4015. 3 October 2016

SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.
Schmidt, V. and Schulz, N. and Yan, X. and Schürmann, A. and Kempa, S. and Kern, M. and Blüher, M. and Poy, M.N. and Olivecrona, G. and Willnow, T.E.
Journal of Clinical Investigation 126 (7): 2706-2720. 1 July 2016

Targeting human melanoma neoantigens by T cell receptor gene therapy.
Leisegang, M. and Kammertoens, T. and Uckert, W. and Blankenstein, T.
Journal of Clinical Investigation 126 (3): 854-858. 1 March 2016

2015

High salt reduces the activation of IL-4- and IL-13-stimulated macrophages.
Binger, K.J. and Gebhardt, M. and Heinig, M. and Rintisch, C. and Schroeder, A. and Neuhofer, W. and Hilgers, K. and Manzel, A. and Schwartz, C. and Kleinewietfeld, M. and Voelkl, J. and Schatz, V. and Linker, R.A. and Lang, F. and Voehringer, D. and Wright, M.D. and Hubner, N. and Dechend, R. and Jantsch, J. and Titze, J. and Müller, D.N.
Journal of Clinical Investigation 125 (11): 4223-4238. 2 November 2015

MHCII-independent CD4(+) T cells protect injured CNS neurons via IL-4.
Walsh, J.T. and Hendrix, S. and Boato, F. and Smirnov, I. and Zheng, J. and Lukens, J.R. and Gadani, S. and Hechler, D. and Gölz, G. and Rosenberger, K. and Kammertöns, T. and Vogt, J. and Vogelaar, C. and Siffrin, V. and Radjavi, A. and Fernandez-Castaneda, A. and Gaultier, A. and Gold, R. and Kanneganti, T.D. and Nitsch, R. and Zipp, F. and Kipnis, J.
Journal of Clinical Investigation 125 (2): 699-714. 2 February 2015

Defective removal of ribonucleotides from DNA promotes systemic autoimmunity.
Günther, C. and Kind, B. and Reijns, M.A.M. and Berndt, N. and Martinez-Bueno, M. and Wolf, C. and Tüngler, V. and Chara, O. and Lee, Y.A. and Hübner, N. and Bicknell, L. and Blum, S. and Krug, C. and Schmidt, F. and Kretschmer, S. and Koss, S. and Astell, K.R. and Ramantani, G. and Bauerfeind, A. and Morris, D.L. and Cunninghame Graham, D.S. and Bubeck, D. and Leitch, A. and Ralston, S.H. and Blackburn, E.A. and Gahr, M. and Witte, T. and Vyse, T.J. and Melchers, I. and Mangold, E. and Nöthen, M.M. and Aringer, M. and Kuhn, A. and Lüthke, K. and Unger, L. and Bley, A. and Lorenzi, A. and Isaacs, J.D. and Alexopoulou, D. and Conrad, K. and Dahl, A. and Roers, A. and Alarcon-Riquelme, M.E. and Jackson, A.P. and Lee-Kirsch, M.A.
Journal of Clinical Investigation 125 (1): 413-424. 2 January 2015

2014

Human satellite cells have regenerative capacity and are genetically manipulable.
Marg, A. and Escobar, H. and Gloy, S. and Kufeld, M. and Zacher, J. and Spuler, A. and Birchmeier, C. and Izsvák, Z. and Spuler, S.
Journal of Clinical Investigation 124 (10): 4257-4265. 1 October 2014

RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing.
Maatz, H. and Jens, M. and Liss, M. and Schafer, S. and Heinig, M. and Kirchner, M. and Adami, E. and Rintisch, C. and Dauksaite, V. and Radke, M.H. and Selbach, M. and Barton, P.J.R. and Cook, S.A. and Rajewsky, N. and Gotthardt, M. and Landthaler, M. and Hubner, N.
Journal of Clinical Investigation 124 (8): 3419-3430. 1 August 2014

α-intercalated cells defend the urinary system from bacterial infection.
Paragas, N. and Kulkarni, R. and Werth, M. and Schmidt-Ott, K.M. and Forster, C. and Deng, R. and Zhang, Q. and Singer, E. and Klose, A.D. and Shen, T.H. and Francis, K.P. and Ray, S. and Vijayakumar, S. and Seward, S. and Bovino, M.E. and Xu, K. and Takabe, Y. and Amaral, F.E. and Mohan, S. and Wax, R. and Corbin, K. and Sanna-Cherchi, S. and Mori, K. and Johnson, L. and Nickolas, T. and D’Agati, V. and Lin, C.S. and Qiu, A. and Al-Awqati, Q. and Ratner, A.J. and Barasch, J.
Journal of Clinical Investigation 124 (7): 2963-2976. 1 July 2014

TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction.
Ragancokova, D. and Rocca, E. and Oonk, A.M.M. and Schulz, H. and Rohde, E. and Bednarsch, J. and Feenstra, I. and Pennings, R.J.E. and Wende, H. and Garratt, A.N.
Journal of Clinical Investigation 124 (3): 1214-1227. 3 March 2014

Disruption of vascular Ca2+-activated chloride currents lowers blood pressure.
Heinze, C. and Seniuk, A. and Sokolov, M.V. and Huebner, A.K. and Klementowicz, A.E. and Szijártó, I.A. and Schleifenbaum, J. and Vitzthum, H. and Gollasch, M. and Ehmke, H. and Schroeder, B.C. and Hübner, C.A.
Journal of Clinical Investigation 124 (2): 675-686. 3 February 2014

Changes in neural network homeostasis trigger neuropsychiatric symptoms.
Winkelmann, A. and Maggio, N. and Eller, J. and Caliskan, G. and Semtner, M. and Häussler, U. and Jüttner, R. and Dugladze, T. and Smolinsky, B. and Kowalczyk, S. and Chronowska, E. and Schwarz, G. and Rathjen, F.G. and Rechavi, G. and Haas, C.A. and Kulik, A. and Gloveli, T. and Heinemann, U. and Meier, J.C.
Journal of Clinical Investigation 124 (2): 696-711. 3 February 2014

2013

Immune cells control skin lymphatic electrolyte homeostasis and blood pressure.
Wiig, H and Schröder, A and Neuhofer, W and Jantsch, J and Kopp, C and Karlsen, T.V. and Boschmann, M and Goss, J and Bry, M and Rakova, N and Dahlmann, A and Brenner, S and Tenstad, O and Nurmi, H and Mervaala, E and Wagner, H and Beck, FX and Müller, D.N. and Kerjaschki, D and Luft, F.C. and Harrison, D.G. and Alitalo, K and Titze, J
Journal of Clinical Investigation 123 (7): 2803-2815. 1 July 2013

CXCL5 limits macrophage foam cell formation in atherosclerosis.
Rousselle, A. and Qadri, F. and Leukel, L. and Yilmaz, R. and Fontaine, J.F. and Sihn, G. and Bader, M. and Ahluwalia, A. and Duchene, J.
Journal of Clinical Investigation 123 (3): 1343-1347. 1 March 2013

Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance.
Willimsky, G. and Schmidt, K. and Loddenkemper, C. and Gellermann, J. and Blankenstein, T.
Journal of Clinical Investigation 123 (3): 1032-1043. 1 March 2013

2012

A misplaced lncRNA causes brachydactyly in humans.
Maass, P.G. and Rump, A. and Schulz, H. and Stricker, S. and Schulze, L. and Platzer, K. and Aydin, A. and Tinschert, S. and Goldring, M.B. and Luft, F.C. and Baehring, S.
Journal of Clinical Investigation 122 (11): 3990-4002. 1 November 2012

2011

Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice.
Gangadharan, V. and Wang, R. and Ulzhoefer, B. and Luo, C. and Bardoni, R. and Bali, K.K. and Agarwal, N. and Tegeder, I. and Hildebrandt, U. and Nagy, G.G. and Todd, A.J. and Ghirri, A. and Haeussler, A. and Sprengel, R. and Seeburg, P.H. and Macdermott, A.B. and Lewin, G.R. and Kuner, R.
Journal of Clinical Investigation 121 (4): 1608-1623. 1 April 2011

2010

MHC-restricted fratricide of human lymphocytes expressing survivin-specific transgenic T cell receptors.
Leisegang, M. and Wilde, S. and Spranger, S. and Milosevic, S. and Frankenberger, B. and Uckert, W. and Schendel, D.J.
Journal of Clinical Investigation 120 (11): 3869-3877. 1 November 2010

Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease.
Joutel, A. and Monet-Lepretre, M. and Gosele, C. and Baron-Menguy, C. and Hammes, A. and Schmidt, S. and Lemaire-Carrette, B. and Domenga, V. and Schedl, A. and Lacombe, P. and Huebner, N.
Journal of Clinical Investigation 120 (2): 433-445. 1 February 2010

The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease.
Na, I.K. and Lu, S.X. and Yim, N.L. and Goldberg, G.L. and Tsai, J. and Rao, U. and Smith, O.M. and King, C.G. and Suh, D. and Hirschhorn-Cymerman, D. and Palomba, L. and Penack, O. and Holland, A.M. and Jenq, R.R. and Ghosh, A. and Tran, H. and Merghoub, T. and Liu, C. and Sempowski, G.D. and Ventevogel, M. and Beauchemin, N. and van den Brink, M.R.M.
Journal of Clinical Investigation 120 (1): 343-356. January 2010

2009

The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.
Rueder, C. and Hoepken, U.E. and Wolf, J. and Mittruecker, H.W. and Engels, B. and Erdmann, B. and Wollenzin, S. and Uckert, W. and Doerken, B. and Rehm, A.
Journal of Clinical Investigation 119 (8): 2184-2203. August 2009

Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation.
Huck, K. and Feyen, O. and Niehues, T. and Rueschendorf, F. and Huebner, N. and Laws, H.J. and Telieps, T. and Knapp, S. and Wacker, H.H. and Meindl, A. and Jumaa, H. and Borkhardt, A.
Journal of Clinical Investigation 119 (5): 1350-1358. May 2009

2008

Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice.
Fu, J. and Gerhardt, H. and McDaniel, J.M. and Xia, B. and Liu, X. and Ivanciu, L. and Ny, A. and Hermans, K. and Silasi-Mansat, R. and McGee, S. and Nye, E. and Ju, T. and Ramirez, M.I. and Carmeliet, P. and Cummings, R.D. and Lupu, F. and Xia, L.
Journal of Clinical Investigation 118 (11): 3725-3737. November 2008

2007

A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.
Steidl, U. and Steidl, C. and Ebralidze, A. and Chapuy, B. and Han, H.J. and Will, B. and Rosenbauer, F. and Becker, A. and Wagner, K. and Koschmieder, S. and Kobayashi, S. and Costa, D.B. and Schulz, T. and OBrien, K.B. and Verhaak, R.G.W. and Delwel, R. and Haase, D. and Truemper, L. and Krauter, J. and Kohwi-Shigematsu, T. and Griesinger, F. and Tenen, D.G.
Journal of Clinical Investigation 117 (9): 2611-2620. 4 September 2007

Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3.
Fielitz, J. and Kim, M.S. and Shelton, J.M. and Latif, S. and Spencer, J.A. and Glass, D.J. and Richardson, J.A. and Bassel-Duby, R. and Olson, E.N.
Journal of Clinical Investigation 117 (9): 2486-2495. September 2007

TRAIL limits excessive host immune responses in bacterial meningitis.
Hoffmann, O. and Priller, J. and Prozorovski, T. and Schulze-Topphoff, U. and Baeva, N. and Lunemann, J.D. and Aktas, O. and Mahrhofer, C. and Stricker, S. and Zipp, F. and Weber, J.R.
Journal of Clinical Investigation 117 (7): 2004-2013. 2 July 2007

Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice.
Rust, M.B. and Alper, S.L. and Rudhard, Y. and Shmukler, B.E. and Vicente, R. and Brugnara, C. and Trudel, M. and Jentsch, T.J. and Huebner, C.A.
Journal of Clinical Investigation 117 (6): 1708-1717. 1 June 2007

2006

Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis.
Visekruna, A. and Joeris, T. and Seidel, D. and Kroesen, A. and Loddenkemper, C. and Zeitz, M. and Kaufmann, S.H.E. and Schmidt-Ullrich, R. and Steinhoff, U.
Journal of Clinical Investigation 116 (12): 3195-3203. December 2006

Arrhythmogenic right ventricular cardiomyopathy: moving toward mechanism.
MacRae, C.A. and Birchmeier, W. and Thierfelder, L.
Journal of Clinical Investigation 116 (7): 1825-1828. July 2006

Pericytes limit tumor cell metastasis.
Xian, X. and Håkansson, J. and Ståhlberg, A. and Lindblom, P. and Betsholtz, C. and Gerhardt, H. and Semb, H.
Journal of Clinical Investigation 116 (3): 642-651. 1 March 2006

2005

Chloride channel diseases resulting from impaired transepithelial transport or vesicular function.
Jentsch, T.J. and Maritzen, T. and Zdebik, A.A.
Journal of Clinical Investigation 115 (8): 2039-2046. August 2005

Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury.
Mori, K. and Lee, H.T. and Rapoport, D. and Drexler, I.R. and Foster, K. and Yang, J. and Schmidt-Ott, K.M. and Chen, X. and Li, J.Y. and Weiss, S. and Mishra, J. and Cheema, F.H. and Markowitz, G. and Suganami, T. and Sawai, K. and Mukoyama, M. and Kunis, C. and D'Agati, V. and Devarajan, P. and Barasch, J.
Journal of Clinical Investigation 115 (3): 610-621. March 2005

2004

Cellular senescence in cancer treatment: friend or foe?
Kahlem, P. and Doerken, B. and Schmitt, C.A.
Journal of Clinical Investigation 113 (2): 169-174. January 2004

2002

In vivo bradykinin B2 receptor activation reduces renal fibrosis.
Schanstra, J.P. and Neau, E. and Drogoz, P. and Gomez, M.A.A. and Novoa, J.M.L. and Calise, D. and Pecher, C. and Bader, M. and Girolami, J.P. and Bascands, J.L.
Journal of Clinical Investigation 110 (3): 371-379. 1 August 2002

2001

Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity.
Holst, P.J. and Rosenkilde, M.M. and Manfra, D. and Chen, S.C. and Wiekowski, M.T. and Holst, B. and Cifire, F. and Lipp, M. and Schwartz, T.W. and Lira, S.A.
Journal of Clinical Investigation 108 (12): 1789-1796. December 2001

2000

Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP.
Kaufmann, J.E. and Oksche, A. and Wollheim, C.B. and Guenther, G. and Rosenthal, W. and Vischer, U.M.
Journal of Clinical Investigation 106 (1): 107-116. July 2000

Cubilin is an albumin binding protein important for renal tubular albumin reabsorption.
Birn, H. and Fyfe, J.C. and Jacobsen, C. and Mounier, F. and Verroust, P.J. and Orskov, H. and Willnow, T.E. and Moestrup, S.K. and Christensen, E.I.
Journal of Clinical Investigation 105 (10): 1353-1361. May 2000

1999

Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor.
Wallukat, G. and Homuth, V. and Fischer, T. and Lindschau, C. and Horstkamp, B. and Jupner, A. and Baur, E. and Nissen, E. and Vetter, K. and Neichel, D. and Dudenhausen, J.W. and Haller, H. and Luft, F.C.
Journal of Clinical Investigation 103 (7): 945-952. 1 April 1999

1998

beta(2)-glycoprotein-1 (apolipoprotein H) and beta(2)-glycoprotein-1-phospholipid complex harbor a recognition site for the endocytic receptor megalin.
Moestrup, S.K. and Schousboe, I. and Jacobsen, C. and Leheste, J.R. and Christensen, E.I. and Willnow, T.E.
Journal of Clinical Investigation 102 (5): 902-909. 1 September 1998

The B1-agonist [des-Arg10]-kallidin activates transcription factor NF-kappaB and induces homologous upregulation of the bradykinin B1-receptor in cultured human lung fibroblasts.
Schanstra, J.P. and Bataille, E. and Castano, M.E.M. and Barascud, Y. and Hirtz, C. and Pesquero, J.B. and Pecher, C. and Gauthier, F. and Girolami, J.P. and Bascands, J.L.
Journal of Clinical Investigation 101 (10): 2080-2091. 15 May 1998

Vasoactive intestinal peptide, forskolin, and genistein increase apical CFTR trafficking in the rectal gland of the spiny dogfish, Squalus acanthias. Acute regulation of CFTR trafficking in an intact epithelium.
Lehrich, R.W. and Aller, S.G. and Webster, P. and Marino, C.R. and Forrest, J.N. .J.r.
Journal of Clinical Investigation 101 (4): 737-745. 15 February 1998

Inducible inactivation of hepatic LRP gene by Cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants.
Rohlmann, A. and Gotthardt, M. and Hammer, R.E. and Herz, J.
Journal of Clinical Investigation 101 (3): 689-695. 1 February 1998

Angiotensinogen gene and hypertension in Chinese.
Niu, T.H. and Xu, X.P. and Rogus, J. and Zhou, Y.S. and Chen, C.Z. and Yang, J.H. and Fang, Z. and Schmitz, C. and Zhao, J.H. and Rao, V.S. and Lindpaintner, K.
Journal of Clinical Investigation 101 (1): 188-194. 1 January 1998

1997

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.
Bargou, R.C. and Emmerich, F. and Krappmann, D. and Bommert, K. and Mapara, M.Y. and Arnold, W. and Royer, H.D. and Grinstein, E. and Greiner, A. and Scheidereit, C. and Doerken, B.
Journal of Clinical Investigation 100 (12): 2961-2969. 15 December 1997

Tissue and development specific expression of multiple alternatively spliced transcripts of rat neuronal nitric oxide synthase.
Lee, M.A. and Cai, L. and Huebner, N. and Lee, Y.A. and Lindpaintner, K.
Journal of Clinical Investigation 100 (6): 1507-1512. 15 September 1997

Reconstitution of mutant V2 vasopressin receptors by adenovirus mediated gene transfer. Molecular basis and clinical implication.
Schoeneberg, T. and Sandig, V. and Wess, J. and Gudermann, T. and Schultz, G.
Journal of Clinical Investigation 100 (6): 1547-1556. 15 September 1997

Identification of a cis-acting regulatory element conferring inducibility of the atrial natriuretic factor gene in acute pressure overload.
von Harsdorf, R. and Edwards, J.G. and Shen, Y.T. and Kudej, R.K. and Dietz, R. and Leinwand, L.A. and Nadal-Ginard, B. and Vatner, S.F.
Journal of Clinical Investigation 100 (5): 1294-1304. 1 September 1997

Novel splice donor site mutation in the cardiac myosin binding protein-C gene in familial hypertrophic cardiomyopathy: characterization of cardiac transcript and protein.
Rottbauer, W. and Gautel, M. and Zehelein, J. and Labeit, S. and Franz, W.M. and Fischer, C. and Vollrath, B. and Mall, G. and Dietz, R. and Kuebler, W. and Katus, H.A.
Journal of Clinical Investigation 100 (2): 475-482. 15 July 1997

Idiopathic low molecular weight proteinuria associated with hypercalciuric nephrocalcinosis in Japanese children is due to mutations of the renal chloride channel (CLCN5).
Lloyd, S.E. and Pearce, S.H. and Guenther, W. and Kawaguchi, H. and Igarashi, T. and Jentsch, T.J. and Thakker, R.V.
Journal of Clinical Investigation 99 (5): 967-974. 1 March 1997

1996

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.
Berg, D.J. and Davidson, N. and Kuehn, R. and Mueller, W. and Menon, S. and Holland, G. and Thompson-Snipes, L. and Leach, M.W. and Rennick, D.
Journal of Clinical Investigation 98 (4): 1010-1020. 15 August 1996

Conditional gene targeting.
Rajewsky, K. and Gu, H. and Kuehn, R. and Betz, U.A. and Mueller, W. and Roes, J. and Schwenk, F.
Journal of Clinical Investigation 98 (3): 600-603. 1 August 1996

Regulation of human heart contractility by essential myosin light chain isoforms.
Morano, M. and Zacharzowski, U. and Maier, M. and Lange, P.E. and Alexi-Meskishvili, V. and Haase, H. and Morano, I.
Journal of Clinical Investigation 98 (2): 467-473. 15 July 1996

Association and cosegregation of stroke with impaired edothelium-dependent vasorelaxation in stroke prone, spontaneously hypertensive rats.
Volpe, M. and Iaccarino, G. and Vecchione, C. and Rizzoni, D. and Russo, R. and Rubattu, S. and Condorelli, G. and Ganten, U. and Ganten, D. and Trimarco, B. and Lindpaintner, K.
Journal of Clinical Investigation 98 (2): 256-261. 15 July 1996

Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice.
Bargou, R.C. and Wagener, C. and Bommert, K. and Mapara, M.Y. and Daniel, P.T. and Arnold, W. and Dietel, M. and Guski, H. and Feller, A. and Royer, H.D. and Doerken, B.
Journal of Clinical Investigation 97 (11): 2651-2659. 1 June 1996

1995

Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.
Berg, D.J. and Kuehn, R. and Rajewsky, K. and Mueller, W. and Menon, S. and Davidson, N. and Gruenig, G. and Rennick, D.
Journal of Clinical Investigation 96 (5): 2339-2347. November 1995

Familial hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome maps to a locus on chromosome 7q3.
MacRae, C.A. and Ghaisas, N. and Kass, S. and Donnelly, S. and Basson, C.T. and Watkins, H.C. and Anan, R. and Thierfelder, L.H. and McGarry, K. and Rowland, E. and McKenna, W.J. and Seidman, J.G. and Seidman, C.E.
Journal of Clinical Investigation 96 (3): 1216-1220. September 1995

The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells.
Stoll, M. and Steckelings, U.M. and Paul, M. and Bottari, S.P. and Metzger, R. and Unger, T.
Journal of Clinical Investigation 95 (2): 651-657. February 1995

1994

C/EBP beta regulation of the tumor necrosis factor alpha gene.
Pope, R.M. and Leutz, A. and Ness, S.A.
Journal of Clinical Investigation 94 (4): 1449-1455. October 1994

Augmented agonist induced Ca2+-sensitization of coronary artery contraction in genetically hypertensive rats - evidence for altered signal transduction in the coronary smooth muscle cells.
Satoh, S. and Kreutz, R. and Wilm, C. and Ganten, D. and Pfitzer, G.
Journal of Clinical Investigation 94 (4): 1397-1403. October 1994

Gene expression, localization, and characterization of endothelin A and B receptors in the human adrenal cortex.
Rossi, G.P. and Albertin, G. and Belloni, A. and Zanin, L. and Biasolo, M.A. and Prayer-Galetti, T. and Bader, M. and Nussdorfer, G.G. and Palu, G. and Pessina, A.C.
Journal of Clinical Investigation 94 (3): 1226-1234. September 1994

Prognostic implications of novel beta cardiac myosin heavy chain gene mutations that cause familial hypertrophic cardiomyopathy.
Anan, R. and Greve, G. and Thierfelder, L.H. and Watkins, H. and McKenna, W.J. and Solomon, S. and Vecchio, C. and Shono, H. and Nakao, S. and Tanaka, H.
Journal of Clinical Investigation 93 (1): 280-285. January 1994

1993

Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones.
Meinl, E. and Weber, F. and Drexler, K. and Morelle, C. and Ott, M. and Saruhan-Direskeneli, G. and Goebels, N. and Ertl, B. and Jechart, G. and Giegerich, G. and Schoenbeck, S. and Bannwarth, W. and Wekerle, H. and Hohlfeld, R.
Journal of Clinical Investigation 92 (6): 2633-2643. December 1993

X-linked nephrogenic diabetes insipidus mutations in North America and the Hopewell hypothesis.
Bichet, D.G. and Arthus, M.F. and Lonergan, M. and Hendy, G.N. and Paradis, A.J. and Fujiwara, T.M. and Morgan, K. and Gregory, M.C. and Rosenthal, W. and Didwania, A.
Journal of Clinical Investigation 92 (3): 1262-1268. September 1993

A circulating substance cross-reacting with antiimidazoline antibodies.
Dontenwill, M. and Molines, A. and Verdun, A. and Bricca, G. and Laurent, S. and Bousquet, P.
Journal of Clinical Investigation 92 (2): 1068-1072. August 1993

Na+/H+ exchange in human lymphocytes and platelets in chronic and subacute metabolic acidosis.
Reusch, H.P. and Reusch, R. and Rosskopf, D. and Siffert, W. and Mann, J.F. and Luft, F.C.
Journal of Clinical Investigation 92 (2): 858-865. August 1993

Cellular localization and regional distribution of an angiotensin II-forming chymase in the heart.
Urata, H. and Boehm, K.D. and Philip, A. and Kinoshita, A. and Gabrovsek, J. and Bumpus, F.M. and Husain, A.
Journal of Clinical Investigation 91 (4): 1269-1281. April 1993

Increased adrenal renin in transgenic hypertensive rats, TGR(mREN2)27, and its regulation by cAMP, angiotensin II and calcium.
Peters, J. and Muenter, K. and Bader, M. and Hackenthal, E. and Mullins, J.J. and Ganten, D.
Journal of Clinical Investigation 91 (3): 742-747. March 1993

1992

Sporadic hypertrophic cardiomyopathy due to de novo myosin mutations.
Watkins, H. and Thierfelder, L. and Hwang, D.S. and McKenna, W. and Seidman, J.G. and Seidman, C.E.
Journal of Clinical Investigation 90 (5): 1666-1671. November 1992

Transplantation of thymic autoimmune microenvironment to severe combined immunodeficiency mice. A new model of myasthenia gravis.
Schoenbeck, S. and Padberg, F. and Hohlfeld, R. and Wekerle, H.
Journal of Clinical Investigation 90 (1): 245-250. July 1992

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