Browse by Research Team

2025

Macrophage trafficking contributes to gut-brain crosstalk in hypertension.
Barraud, C.M., Forcari, G., Rauch, A., Zakarauskas-Seth, B.I., Bartolomaeus, H., Filosa, A., Wilck, N. and Sawamiphak, S.
Circulation Research 25 June 2025 (In Press)

Gut-derived metabolites as treatment targets in chronic kidney disease - an avenue toward personalized medicine.
Holle, J. and Bartolomaeus, H.
Pediatric Nephrology 40 (5): 1505-1510. May 2025

Assessing customized multivalent chemokine-binding peptide treatment in a murine model of coxsackievirus B3 myocarditis.
Kelm, N., Kespohl, M., Smagurauskaite, G., Vales, S., Karuppanan, K., Mburu, P., Thiele, A., Pinkert, S., Bukur, T., Mülleder, M., Berndt, N., Klingel, K., Gaida, M.M., Bhattacharya, S. and Beling, A.
Basic Research in Cardiology 120 (2): 393-422. April 2025

Intestinal interstitial fluid isolation provides novel insight into the human host-microbiome interface.
Avery, E.G., Haag, L.M., McParland, V., Kedziora, S.M., Zigra, G.J., Valdes, D.S., Kirchner, M., Popp, O., Geisberger, S., Nonn, O., Karlsen, T.V., N'Diaye, G., Yarritu, A., Bartolomaeus, H., Bartolomaeus, T.U.P., Tagiyeva, N.A., Wimmer, M.I., Haase, N., Zhang, Y.D., Wilhelm, A., Grütz, G., Tenstad, O., Wilck, N., Forslund, S.K., Klopfleisch, R., Kühl, A.A., Atreya, R., Kempa, S., Mertins, P., Siegmund, B., Wiig, H. and Müller, D.N.
Cardiovascular Research 121 (5): 803-816. April 2025

Circulating extracellular vesicles as putative mediators of cardiovascular disease in paediatric chronic kidney disease.
Behrens, F., Holle, J., Chen, C.Y., Ginsbach, L.F., Krause, B.C., Bruning, U., Kriegel, F.L., Kaiser, T., Szijártó, I.A., Anandakumar, H., Lehmann, K., Schumacher, F., Durek, P., Heinrich, F.F., Lodka, D., Hoffmann, C., Borchardt, A.A., Peters, L., Michalick, L., Querfeld, U., Bufler, P., Luch, A., Kleuser, B., Kirwan, J.A., Forslund, S.K., Thumfahrt, J., Müller, D., Wilck, N., Mashreghi, M.F., Löber, U., Bartolomaeus, H., Kuebler, W.M. and Simmons, S.
Journal of Extracellular Vesicles 14 (3): e70062. March 2025

Gut microbiome alterations precede graft rejection in kidney transplantation patients.
Holle, J., Reitmeir, R., Behrens, F., Singh, D., Schindler, D., Potapenko, O., McParland, V., Anandakumar, H., Kanzelmeyer, N., Sommerer, C., Hartleif, S., Andrassy, J., Heemann, U., Neuenhahn, M., Forslund-Startceva, S.K., Gerhard, M., Oh, J., Wilck, N., Löber, U. and Bartolomaeus, H.
American Journal of Transplantation 18 February 2025 (In Press)

Associations of the adaptive immune system and age-related macular degeneration.
Stürzbecher, L. and Strauss, O.
Advances in Experimental Medicine and Biology 1468 : 3-7. 11 February 2025

Outer retina micro-inflammation is driven by T cell responses prior to retinal degeneration in early age-related macular degeneration.
Stürzbecher, L., Bartolomaeus, H., Bartolomaeus, T.U.P., Bolz, S., Sekulic, A., Ueffing, M., Clark, S.J., Reichhart, N., Crespo-Garcia, S., Wilck, N. and Strauß, O.
Frontiers in Immunology 16 : 1520188. 5 February 2025

A novel approach to modelling acute cardiac decompensation in rats.
Thiele, A., Bartolomaeus, H., Anandakumar, H., Haase, N., Heuser, A., Müller, D.N., Dechend, R. and Wilck, N.
Cardiovascular Research 121 (3): 379-381. February 2025

Characterization of anthracycline-induced cardiotoxicity by diffusion tensor magnetic resonance imaging.
Lohr, D., Thiele, A., Stahnke, M., Braun, V.M., Klopfleisch, R., Klein, O., Dresen, S., Landmesser, U., Foryst-Ludwig, A., Kintscher, U., Schreiber, L.M. and Beyhoff, N.
Basic Research in Cardiology 120 (1): 57-69. February 2025

2024

Gut dysbiosis contributes to TMAO accumulation in CKD.
Holle, J., McParland, V., Anandakumar, H., Gerritzmann, F., Behrens, F., Schumacher, F., Thumfart, J., Eckardt, K.U., Kleuser, B., Bartolomaeus, H. and Wilck, N.
Nephrology Dialysis Transplantation 39 (11): 1923-1926. November 2024

Metformin modulates microbiota and improves blood pressure and cardiac remodeling in a rat model of hypertension.
Wimmer, M.I., Bartolomaeus, H., Anandakumar, H., Chen, C.Y., Vecera, V., Kedziora, S., Kamboj, S., Schumacher, F., Pals, S., Rauch, A., Meisel, J., Potapenko, O., Yarritu, A., Bartolomaeus, T.U.P., Samaan, M., Thiele, A., Stürzbecher, L., Geisberger, S.Y., Kleuser, B., Oefner, P.J., Haase, N., Löber, U., Gronwald, W., Forslund-Startceva, S.K., Müller, D.N. and Wilck, N.
Acta Physiologica 240 (11): e14226. November 2024

Medium term (> 12 months) outcomes after laparoscopic hiatal hernia repair without conventional fundoplication using PH4B‑mesh implant (Phasix™) in 176 reflux patients: experience and technique.
Siemssen, B., Dahlke, P.M., Behrens, F., Hentschel, F. and Ibach, M.J.
Hernia 28 (5): 1641-1647. October 2024

Baseline microbiome composition impacts resilience to and recovery following antibiotics.
Chen, C.Y., Löber, U., Bartolomaeus, H., Maier, L., Müller, D.N., Wilck, N., Jarquín-Díaz, V.H. and Forslund-Startceva, S.K.
bioRxiv : 2024.03.31.587491. 31 March 2024

Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung.
Dörner, P.J., Anandakumar, H., Röwekamp, I., Fiocca Vernengo, F., Millet Pascual-Leone, B., Krzanowski, M., Sellmaier, J., Brüning, U., Fritsche-Guenther, R., Pfannkuch, L., Kurth, F., Milek, M., Igbokwe, V., Löber, U., Gutbier, B., Holstein, M., Heinz, G.A., Mashreghi, M.F., Schulte, L.N., Klatt, A.B., Caesar, S., Wienhold, S.M., Offermanns, S., Mack, M., Witzenrath, M., Jordan, S., Beule, D., Kirwan, J.A., Forslund, S.K., Wilck, N., Bartolomaeus, H., Heimesaat, M.M. and Opitz, B.
Nature Communications 15 (1): 2788. 30 March 2024

IA-PACS-CFS: a double-blinded, randomized, sham-controlled, exploratory trial of immunoadsorption in patients with chronic fatigue syndrome (CFS) including patients with post-acute COVID-19 CFS (PACS-CFS).
Preßler, H., Machule, M.L., Ufer, F., Bünger, I., Li, L.Y., Buchholz, E., Werner, C., Beraha, E., Wagner, F., Metz, M., Burock, S., Bruckert, L., Franke, C., Wilck, N., Krüger, A., Reshetnik, A., Eckardt, K.U., Endres, M. and Prüss, H.
Trials 25 (1): 172. 7 March 2024

Sodium as an important regulator of immunometabolism.
Miyauchi, H., Geisberger, S., Luft, F.C., Wilck, N., Stegbauer, J., Wiig, H., Dechend, R., Jantsch, J., Kleinewietfeld, M., Kempa, S. and Mueller, D.N.
Hypertension 81 (3): 426-435. March 2024

Gut-immune axis and cardiovascular risk in chronic kidney disease.
Behrens, F., Bartolomaeus, H., Wilck, N. and Holle, J.
Clinical Kidney Journal 17 (1): sfad303. January 2024

Segmental patterning of microbiota and immune cells in the murine intestinal tract.
Anandakumar, H., Rauch, A., Wimmer, M.I., Yarritu, A., Koch, G., McParland, V., Bartolomaeus, H. and Wilck, N.
Gut Microbes 16 (1): 2398126. 2024

2023

Diastolische Dysfunktion und HFpEF bei CKD: Ein Update [Diastolic dysfunction and HFpEF in CKD: An update].
Szijártó, I.A. and Wilck, N.
Nephrologie 18 : 361–369. November 2023

Trends and perspectives for improving quality of chronic kidney disease care: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.
Eckardt, K.U., Delgado, C., Heerspink, H.J.L., Pecoits-Filho, R., Ricardo, A.C., Stengel, B., Tonelli, M., Cheung, M., Jadoul, M., Winkelmayer, W.C. and Kramer, H.
Kidney International 104 (5): 888-903. November 2023

Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage.
Avery, E.G., Bartolomaeus, H., Rauch, A., Chen, C.Y., N'Diaye, G., Löber, U., Bartolomaeus, T.U.P., Fritsche-Guenther, R., Rodrigues, A.F., Yarritu, A., Zhong, C., Fei, L., Tsvetkov, D., Todiras, M., Park, J.K., Markó, L., Maifeld, A., Patzak, A., Bader, M., Kempa, S., Kirwan, J.A., Forslund, S.K., Müller, D.N. and Wilck, N.
Cardiovascular Research 119 (6): 1441-1452. May 2023

G(q)-mediated arrhythmogenic signaling promotes atrial fibrillation.
Hohendanner, F., Prabhu, A., Wilck, N., Stangl, V., Pieske, B., Stangl, K. and Althoff, T.F.
Biomedicines 11 (2): 526. 11 February 2023

Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs.
Côrte-Real, B.F., Hamad, I., Arroyo Hornero, R., Geisberger, S., Roels, J., Van Zeebroeck, L., Dyczko, A., van Gisbergen, M.W., Kurniawan, H., Wagner, A., Yosef, N., Weiss, S.N.Y., Schmetterer, K.G., Schröder, A., Krampert, L., Haase, S., Bartolomaeus, H., Hellings, N., Saeys, Y., Dubois, L.J., Brenner, D., Kempa, S., Hafler, D.A., Stegbauer, J., Linker, R.A., Jantsch, J., Müller, D.N. and Kleinewietfeld, M.
Cell Metabolism 35 (2): 299-315. 7 February 2023

2022

Inflammation in children with chronic kidney disease linked to gut dysbiosis and metabolite imbalance.
Holle, J., Bartolomaeus, H., Löber, U., Behrens, F., Bartolomaeus, T.U.P., Anandakumar, H., Wimmer, M., Vu, D.L., Kuhring, M., Brüning, U., Maifeld, A., Geisberger, S., Kempa, S., Schumacher, F., Kleuser, B., Bufler, P., Querfeld, U., Kitschke, S., Engler, D., Kuhrt, L.D., Drechsel, O., Eckardt, K.U., Forslund, S., Thürmer, A., McParland, V., Kirwan, J., Wilck, N. and Mueller, D.
Journal of the American Society of Nephrology 33 (12): 2259-2275. December 2022

Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications.
Gawałko, M., Agbaedeng, T.A., Saljic, A., Mueller, D.N., Wilck, N., Schnabel, R., Penders, J., Rienstra, M., van Gelder, I., Jespersen, T., Schotten, U., Crijns, H.J.G.M., Kalman, J.M., Sanders, P., Nattel, S., Dobrev, D. and Linz, D.
Cardiovascular Research 118 (11): 2415–2427. July 2022

Pharmacological inhibition of adipose tissue Adipose Triglyceride Lipase (ATGL) by Atglistatin prevents catecholamine-induced myocardial damage.
Thiele, A., Luettges, K., Ritter, D., Beyhoff, N., Smeir, E., Grune, J., Steinhoff, J.S., Schupp, M., Klopfleisch, R., Rothe, M., Wilck, N., Bartolomaeus, H., Migglautsch, A.K., Breinbauer, R., Kershaw, E.E., Grabner, G.F., Zechner, R., Kintscher, U. and Foryst-Ludwig, A.
Cardiovascular Research 118 (11): 2488-2505. July 2022

Increased salt intake decreases diet-induced thermogenesis in healthy volunteers: a randomized placebo-controlled study.
Mähler, A., Klamer, S., Maifeld, A., Bartolomaeus, H., Markó, L., Chen, C.Y., Forslund, S.K., Boschmann, M., Müller, D.N. and Wilck, N.
Nutrients 14 (2): 253. 7 January 2022

Skin sodium accumulates in psoriasis and reflects disease severity.
Maifeld, A., Wild, J., Karlsen, T.V., Rakova, N., Wistorf, E., Linz, P., Jung, R., Birukov, A., Gimenez-Rivera, V.A., Wilck, N., Bartolomaeus, T., Dechend, R., Kleinewietfeld, M., Forslund, S.K., Krause, A., Kokolakis, G., Philipp, S., Clausen, B.E., Brand, A., Waisman, A., Kurschus, F.C., Wegner, J., Schultheis, M., Luft, F.C., Boschmann, M., Kelm, M., Wiig, H., Kuehne, T., Müller, D.N., Karbach, S. and Markó, L.
Journal of Investigative Dermatology 142 (1): 166-178. January 2022

2021

Bacterial metabolites and cardiovascular risk in children with chronic kidney disease.
Schlender, J., Behrens, F., McParland, V., Müller, D., Wilck, N., Bartolomaeus, H. and Holle, J.
Molecular and Cellular Pediatrics 8 (1): 17. 22 October 2021

The ubiquitin-proteasome system and autophagy: self-digestion for metabolic health.
Sun-Wang, J.L., Yarritu-Gallego, A., Ivanova, S. and Zorzano, A.
Trends in Endocrinology and Metabolism 32 (8): 594-608. August 2021

What's for dinner? Why a close look at diet and microbiota is worthwhile in experimental hypertension research.
Wilck, N.
Acta Physiologica 232 (4): e13704. August 2021

Salt transiently inhibits mitochondrial energetics in mononuclear phagocytes.
Geisberger, S., Bartolomaeus, H., Neubert, P., Willebrand, R., Zasada, C., Bartolomaeus, T., McParland, V., Swinnen, D., Geuzens, A., Maifeld, A., Krampert, L., Vogl, M., Mähler, A., Wilck, N., Marko, L., Tilic, E., Forslund, S.K., Binger, K.J., Stegbauer, J., Dechend, R., Kleinewietfeld, M., Jantsch, J., Kempa, S. and Müller, D.N.
Circulation 144 (2): 144-158. 13 July 2021

The gut microbiome in hypertension: recent advances and future perspectives.
Avery, E.G., Bartolomaeus, H., Maifeld, A., Marko, L., Wiig, H., Wilck, N., Rosshart, S.P., Forslund, S.K. and Muller, D.N.
Circulation Research 128 (7): 934-950. 2 April 2021

Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients.
Maifeld, A., Bartolomaeus, H., Löber, U., Avery, E.G., Steckhan, N., Markó, L., Wilck, N., Hamad, I., Šušnjar, U., Mähler, A., Hohmann, C., Chen, C.Y., Cramer, H., Dobos, G., Lesker, T.R., Strowig, T., Dechend, R., Bzdok, D., Kleinewietfeld, M., Michalsen, A., Müller, D.N. and Forslund, S.K.
Nature Communications 12 (1): 1970. 30 March 2021

Quantifying technical confounders in microbiome studies.
Bartolomaeus, T.U.P., Birkner, T., Bartolomaeus, H., Löber, U., Avery, E.G., Mähler, A., Weber, D., Kochlik, B., Balogh, A., Wilck, N., Boschmann, M., Müller, D.N., Markó, L. and Forslund, S.K.
Cardiovascular Research 117 (3): 863-875. 1 March 2021

Ernährung und Hypertonie : Worauf man neben der medikamentösen Therapie achten sollte [Nutrition and hypertension : what one should pay attention to in addition to the pharmaceutical treatment].
McParland, V. and Wilck, N.
Internist 62 (3): 269-276. March 2021

2020

Effect of a probiotic on blood pressure in grade 1 hypertension (HYPRO): protocol of a randomized controlled study.
Mähler, A., Wilck, N., Rauch, G., Dechend, R. and Müller, D.N.
Trials 21 (1): 1032. 29 December 2020

The role of the gut microbiota and microbial metabolites in neuroinflammation.
Haase, S., Wilck, N., Haghikia, A., Gold, R., Mueller, D.N. and Linker, R.A.
European Journal of Immunology 50 (12): 1863-1870. December 2020

Der Einfluss der Mikrobiota auf den Blutdruck : Wie Darmbakterien Bluthochdruck und Organschäden beeinflussen.
Wilck, N.
Dialyse aktuell 24 (9): 360-366. November 2020

Blood pressure changes correlate with short-chain fatty acid production potential shifts under a synbiotic intervention.
Bartolomaeus, H., Avery, E.G., Bartolomaeus, T.U.P., Kozhakhmetov, S., Zhumadilov, Z., Müller, D.N., Wilck, N., Kushugulova, A. and Forslund, S.K.
Cardiovascular Research 116 (7): 1252-1253. June 2020

Myocardial evaluation of post-preeclamptic women by CMR: is early risk stratification possible?
Birukov, A., Wiesemann, S., Golic, M., Balogh, A., Marko, L., Rakova, N., Wilck, N., Blaszczyk, E., Lim, C., Weiss, S., Kräker, K., Haase, N., Frolova, A., Jørgensen, J.S., Daub, S., Mueller, D.N., Herse, F., Schulz-Menger, J. and Dechend, R.
JACC: Cardiovascular Imaging 13 (5): 1291-1293. May 2020

B-cell lymphoma/leukemia 10 and angiotensin II-induced kidney injury.
Markó, L., Park, J.K., Henke, N., Rong, S., Balogh, A., Klamer, S., Bartolomaeus, H., Wilck, N., Ruland, J., Forslund, S.K., Luft, F.C., Dechend, R. and Müller, D.N.
Cardiovascular Research 116 (5): 1059-1070. 1 April 2020

Darm-Herz-Achse: Wie Darmbakterien kardiovaskuläre Erkrankungen beeinflussen [Gut-heart axis: how gut bacteria influence cardiovascular diseases].
Bartolomaeus, H., McParland, V. and Wilck, N.
Herz 45 (2): 134-141. April 2020

Natural compound library screening identifies new molecules for the treatment of cardiac fibrosis and diastolic dysfunction.
Schimmel, K., Jung, M., Foinquinos, A., San José, G., Beaumont, J., Bock, K., Grote-Levi, L., Xiao, K., Bär, C., Pfanne, A., Just, A., Zimmer, K., Ngoy, S., López, B., Ravassa, S., Samolovac, S., Janssen-Peters, H., Remke, J., Scherf, K., Dangwal, S., Piccoli, M.T., Kleemiss, F., Kreutzer, F.P., Kenneweg, F., Leonardy, J., Hobuß, L., Santer, L., Do, Q.T., Geffers, R., Braesen, J.H., Schmitz, J., Brandenberger, C., Müller, D.N., Wilck, N., Kaever, V., Bähre, H., Batkai, S., Fiedler, J., Alexander, K.M., Wertheim, B.M., Fisch, S., Liao, R., Diez, J., González, A. and Thum, T.
Circulation 141 (9): 751-767. 3 March 2020

2019

The role of sodium in modulating immune cell function.
Wilck, N., Balogh, A., Markó, L., Bartolomaeus, H. and Müller, D.N.
Nature Reviews Nephrology 15 (9): 546-558. September 2019

Precarious symbiosis between host and microbiome in cardiovascular health.
Bartolomaeus, H., Markó, L., Wilck, N., Luft, F.C., Forslund, S.K. and Muller, D.N.
Hypertension 73 (5): 926-935. May 2019

Sodium chloride triggers Th17 mediated autoimmunity.
Haase, S., Wilck, N., Kleinewietfeld, M., Müller, D.N. and Linker, R.A.
Journal of Neuroimmunology 329 : 9-13. 15 April 2019

Sodium in the microenvironment regulates immune responses and tissue homeostasis.
Müller, D.N., Wilck, N., Haase, S., Kleinewietfeld, M. and Linker, R.A.
Nature Reviews Immunology 19 (4): 243-254. April 2019

Short-chain fatty acid propionate protects from hypertensive cardiovascular damage.
Bartolomaeus, H., Balogh, A., Yakoub, M., Homann, S., Markó, L., Höges, S., Tsvetkov, D., Krannich, A., Wundersitz, S., Avery, E.G., Haase, N., Kräker, K., Hering, L., Maase, M., Kusche-Vihrog, K., Grandoch, M., Fielitz, J., Kempa, S., Gollasch, M., Zhumadilov, Z., Kozhakhmetov, S., Kushugulova, A., Eckardt, K.U., Dechend, R., Rump, L.C., Forslund, S.K., Müller, D.N., Stegbauer, J. and Wilck, N.
Circulation 139 (11): 1407-1421. 12 March 2019

Anti-β1-adrenoreceptor auto-antibodies in elderly heart failure patients.
Trippel, T.D., Mueller, D.N., Obradovic, D., Edelmann, F., Tahirovic, E., Wilck, N., Riemekasten, G., Dragun, D., Busjahn, A., Heidecke, H., Junker, J., Pieske, B., Dungen, H.D. and Dechend, R.
Frontiers in Bioscience 24 : 1037-1049. 1 March 2019

Deletion in mice of X-linked, Brugada syndrome- and atrial fibrillation-associated Kcne5 augments ventricular K(V) currents and predisposes to ventricular arrhythmia.
David, J.P., Lisewski, U., Crump, S.M., Jepps, T.A., Bocksteins, E., Wilck, N., Lossie, J., Roepke, T.K., Schmitt, N. and Abbott, G.W.
FASEB Journal 33 (2): 2537-2552. February 2019