Browse by Research Team

Article

Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung.
Dörner, P.J. and Anandakumar, H. and Röwekamp, I. and Fiocca Vernengo, F. and Millet Pascual-Leone, B. and Krzanowski, M. and Sellmaier, J. and Brüning, U. and Fritsche-Guenther, R. and Pfannkuch, L. and Kurth, F. and Milek, M. and Igbokwe, V. and Löber, U. and Gutbier, B. and Holstein, M. and Heinz, G.A. and Mashreghi, M.F. and Schulte, L.N. and Klatt, A.B. and Caesar, S. and Wienhold, S.M. and Offermanns, S. and Mack, M. and Witzenrath, M. and Jordan, S. and Beule, D. and Kirwan, J.A. and Forslund, S.K. and Wilck, N. and Bartolomaeus, H. and Heimesaat, M.M. and Opitz, B.
Nature Communications 15 (1): 2788. 30 March 2024

Characterization of anthracycline-induced cardiotoxicity by diffusion tensor magnetic resonance imaging.
Lohr, D. and Thiele, A. and Stahnke, M. and Braun, V.M. and Klopfleisch, R. and Klein, O. and Dresen, S. and Landmesser, U. and Foryst-Ludwig, A. and Kintscher, U. and Schreiber, L.M. and Beyhoff, N.
Basic Research in Cardiology 14 March 2024 (In Press)

IA-PACS-CFS: a double-blinded, randomized, sham-controlled, exploratory trial of immunoadsorption in patients with chronic fatigue syndrome (CFS) including patients with post-acute COVID-19 CFS (PACS-CFS).
Preßler, H. and Machule, M.L. and Ufer, F. and Bünger, I. and Li, L.Y. and Buchholz, E. and Werner, C. and Beraha, E. and Wagner, F. and Metz, M. and Burock, S. and Bruckert, L. and Franke, C. and Wilck, N. and Krüger, A. and Reshetnik, A. and Eckardt, K.U. and Endres, M. and Prüss, H.
Trials 25 (1): 172. 7 March 2024

Trends and perspectives for improving quality of chronic kidney disease care: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.
Eckardt, K.U. and Delgado, C. and Heerspink, H.J.L. and Pecoits-Filho, R. and Ricardo, A.C. and Stengel, B. and Tonelli, M. and Cheung, M. and Jadoul, M. and Winkelmayer, W.C. and Kramer, H.
Kidney International 104 (5): 888-903. November 2023

Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage.
Avery, E.G. and Bartolomaeus, H. and Rauch, A. and Chen, C.Y. and N'Diaye, G. and Löber, U. and Bartolomaeus, T.U.P. and Fritsche-Guenther, R. and Rodrigues, A.F. and Yarritu, A. and Zhong, C. and Fei, L. and Tsvetkov, D. and Todiras, M. and Park, J.K. and Markó, L. and Maifeld, A. and Patzak, A. and Bader, M. and Kempa, S. and Kirwan, J.A. and Forslund, S.K. and Müller, D.N. and Wilck, N.
Cardiovascular Research 119 (6): 1441-1452. May 2023

G(q)-mediated arrhythmogenic signaling promotes atrial fibrillation.
Hohendanner, F. and Prabhu, A. and Wilck, N. and Stangl, V. and Pieske, B. and Stangl, K. and Althoff, T.F.
Biomedicines 11 (2): 526. 11 February 2023

Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs.
Côrte-Real, B.F. and Hamad, I. and Arroyo Hornero, R. and Geisberger, S. and Roels, J. and Van Zeebroeck, L. and Dyczko, A. and van Gisbergen, M.W. and Kurniawan, H. and Wagner, A. and Yosef, N. and Weiss, S.N.Y. and Schmetterer, K.G. and Schröder, A. and Krampert, L. and Haase, S. and Bartolomaeus, H. and Hellings, N. and Saeys, Y. and Dubois, L.J. and Brenner, D. and Kempa, S. and Hafler, D.A. and Stegbauer, J. and Linker, R.A. and Jantsch, J. and Müller, D.N. and Kleinewietfeld, M.
Cell Metabolism 35 (2): 299-315. 7 February 2023

Inflammation in children with chronic kidney disease linked to gut dysbiosis and metabolite imbalance.
Holle, J. and Bartolomaeus, H. and Löber, U. and Behrens, F. and Bartolomaeus, T.U.P. and Anandakumar, H. and Wimmer, M. and Vu, D.L. and Kuhring, M. and Brüning, U. and Maifeld, A. and Geisberger, S. and Kempa, S. and Schumacher, F. and Kleuser, B. and Bufler, P. and Querfeld, U. and Kitschke, S. and Engler, D. and Kuhrt, L.D. and Drechsel, O. and Eckardt, K.U. and Forslund, S. and Thürmer, A. and McParland, V. and Kirwan, J. and Wilck, N. and Mueller, D.
Journal of the American Society of Nephrology 33 (12): 2259-2275. December 2022

Pharmacological inhibition of adipose tissue Adipose Triglyceride Lipase (ATGL) by Atglistatin prevents catecholamine-induced myocardial damage.
Thiele, A. and Luettges, K. and Ritter, D. and Beyhoff, N. and Smeir, E. and Grune, J. and Steinhoff, J.S. and Schupp, M. and Klopfleisch, R. and Rothe, M. and Wilck, N. and Bartolomaeus, H. and Migglautsch, A.K. and Breinbauer, R. and Kershaw, E.E. and Grabner, G.F. and Zechner, R. and Kintscher, U. and Foryst-Ludwig, A.
Cardiovascular Research 118 (11): 2488-2505. July 2022

Increased salt intake decreases diet-induced thermogenesis in healthy volunteers: a randomized placebo-controlled study.
Mähler, A. and Klamer, S. and Maifeld, A. and Bartolomaeus, H. and Markó, L. and Chen, C.Y. and Forslund, S.K. and Boschmann, M. and Müller, D.N. and Wilck, N.
Nutrients 14 (2): 253. 7 January 2022

Skin sodium accumulates in psoriasis and reflects disease severity.
Maifeld, A. and Wild, J. and Karlsen, T.V. and Rakova, N. and Wistorf, E. and Linz, P. and Jung, R. and Birukov, A. and Gimenez-Rivera, V.A. and Wilck, N. and Bartolomaeus, T. and Dechend, R. and Kleinewietfeld, M. and Forslund, S.K. and Krause, A. and Kokolakis, G. and Philipp, S. and Clausen, B.E. and Brand, A. and Waisman, A. and Kurschus, F.C. and Wegner, J. and Schultheis, M. and Luft, F.C. and Boschmann, M. and Kelm, M. and Wiig, H. and Kuehne, T. and Müller, D.N. and Karbach, S. and Markó, L.
Journal of Investigative Dermatology 142 (1): 166-178. January 2022

Salt transiently inhibits mitochondrial energetics in mononuclear phagocytes.
Geisberger, S. and Bartolomaeus, H. and Neubert, P. and Willebrand, R. and Zasada, C. and Bartolomaeus, T. and McParland, V. and Swinnen, D. and Geuzens, A. and Maifeld, A. and Krampert, L. and Vogl, M. and Mähler, A. and Wilck, N. and Marko, L. and Tilic, E. and Forslund, S.K. and Binger, K.J. and Stegbauer, J. and Dechend, R. and Kleinewietfeld, M. and Jantsch, J. and Kempa, S. and Müller, D.N.
Circulation 144 (2): 144-158. 13 July 2021

Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients.
Maifeld, A. and Bartolomaeus, H. and Löber, U. and Avery, E.G. and Steckhan, N. and Markó, L. and Wilck, N. and Hamad, I. and Šušnjar, U. and Mähler, A. and Hohmann, C. and Chen, C.Y. and Cramer, H. and Dobos, G. and Lesker, T.R. and Strowig, T. and Dechend, R. and Bzdok, D. and Kleinewietfeld, M. and Michalsen, A. and Müller, D.N. and Forslund, S.K.
Nature Communications 12 (1): 1970. 30 March 2021

Quantifying technical confounders in microbiome studies.
Bartolomaeus, T.U.P. and Birkner, T. and Bartolomaeus, H. and Löber, U. and Avery, E.G. and Mähler, A. and Weber, D. and Kochlik, B. and Balogh, A. and Wilck, N. and Boschmann, M. and Müller, D.N. and Markó, L. and Forslund, S.K.
Cardiovascular Research 117 (3): 863-875. 1 March 2021

Effect of a probiotic on blood pressure in grade 1 hypertension (HYPRO): protocol of a randomized controlled study.
Mähler, A. and Wilck, N. and Rauch, G. and Dechend, R. and Müller, D.N.
Trials 21 (1): 1032. 29 December 2020

Der Einfluss der Mikrobiota auf den Blutdruck : Wie Darmbakterien Bluthochdruck und Organschäden beeinflussen.
Wilck, N.
Dialyse aktuell 24 (9): 360-366. November 2020

B-cell lymphoma/leukemia 10 and angiotensin II-induced kidney injury.
Markó, L. and Park, J.K. and Henke, N. and Rong, S. and Balogh, A. and Klamer, S. and Bartolomaeus, H. and Wilck, N. and Ruland, J. and Forslund, S.K. and Luft, F.C. and Dechend, R. and Müller, D.N.
Cardiovascular Research 116 (5): 1059-1070. 1 April 2020

Darm-Herz-Achse: Wie Darmbakterien kardiovaskuläre Erkrankungen beeinflussen [Gut-heart axis: how gut bacteria influence cardiovascular diseases].
Bartolomaeus, H. and McParland, V. and Wilck, N.
Herz 45 (2): 134-141. April 2020

Natural compound library screening identifies new molecules for the treatment of cardiac fibrosis and diastolic dysfunction.
Schimmel, K. and Jung, M. and Foinquinos, A. and San José, G. and Beaumont, J. and Bock, K. and Grote-Levi, L. and Xiao, K. and Bär, C. and Pfanne, A. and Just, A. and Zimmer, K. and Ngoy, S. and López, B. and Ravassa, S. and Samolovac, S. and Janssen-Peters, H. and Remke, J. and Scherf, K. and Dangwal, S. and Piccoli, M.T. and Kleemiss, F. and Kreutzer, F.P. and Kenneweg, F. and Leonardy, J. and Hobuß, L. and Santer, L. and Do, Q.T. and Geffers, R. and Braesen, J.H. and Schmitz, J. and Brandenberger, C. and Müller, D.N. and Wilck, N. and Kaever, V. and Bähre, H. and Batkai, S. and Fiedler, J. and Alexander, K.M. and Wertheim, B.M. and Fisch, S. and Liao, R. and Diez, J. and González, A. and Thum, T.
Circulation 141 (9): 751-767. 3 March 2020

Short-chain fatty acid propionate protects from hypertensive cardiovascular damage.
Bartolomaeus, H. and Balogh, A. and Yakoub, M. and Homann, S. and Markó, L. and Höges, S. and Tsvetkov, D. and Krannich, A. and Wundersitz, S. and Avery, E.G. and Haase, N. and Kräker, K. and Hering, L. and Maase, M. and Kusche-Vihrog, K. and Grandoch, M. and Fielitz, J. and Kempa, S. and Gollasch, M. and Zhumadilov, Z. and Kozhakhmetov, S. and Kushugulova, A. and Eckardt, K.U. and Dechend, R. and Rump, L.C. and Forslund, S.K. and Müller, D.N. and Stegbauer, J. and Wilck, N.
Circulation 139 (11): 1407-1421. 12 March 2019

Anti-β1-adrenoreceptor auto-antibodies in elderly heart failure patients.
Trippel, T.D. and Mueller, D.N. and Obradovic, D. and Edelmann, F. and Tahirovic, E. and Wilck, N. and Riemekasten, G. and Dragun, D. and Busjahn, A. and Heidecke, H. and Junker, J. and Pieske, B. and Dungen, H.D. and Dechend, R.
Frontiers in Bioscience 24 : 1037-1049. 1 March 2019

Deletion in mice of X-linked, Brugada syndrome- and atrial fibrillation-associated Kcne5 augments ventricular K(V) currents and predisposes to ventricular arrhythmia.
David, J.P. and Lisewski, U. and Crump, S.M. and Jepps, T.A. and Bocksteins, E. and Wilck, N. and Lossie, J. and Roepke, T.K. and Schmitt, N. and Abbott, G.W.
FASEB Journal 33 (2): 2537-2552. February 2019

Review

Sodium as an important regulator of immunometabolism.
Miyauchi, H. and Geisberger, S. and Luft, F.C. and Wilck, N. and Stegbauer, J. and Wiig, H. and Dechend, R. and Jantsch, J. and Kleinewietfeld, M. and Kempa, S. and Mueller, D.N.
Hypertension 81 (3): 426-435. March 2024

Gut-immune axis and cardiovascular risk in chronic kidney disease.
Behrens, F. and Bartolomaeus, H. and Wilck, N. and Holle, J.
Clinical Kidney Journal 17 (1): sfad303. January 2024

Diastolische Dysfunktion und HFpEF bei CKD: Ein Update [Diastolic dysfunction and HFpEF in CKD: An update].
Szijártó, I.A. and Wilck, N.
Nephrologie 18 : 361–369. November 2023

Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications.
Gawałko, M. and Agbaedeng, T.A. and Saljic, A. and Mueller, D.N. and Wilck, N. and Schnabel, R. and Penders, J. and Rienstra, M. and van Gelder, I. and Jespersen, T. and Schotten, U. and Crijns, H.J.G.M. and Kalman, J.M. and Sanders, P. and Nattel, S. and Dobrev, D. and Linz, D.
Cardiovascular Research 118 (11): 2415–2427. July 2022

Bacterial metabolites and cardiovascular risk in children with chronic kidney disease.
Schlender, J. and Behrens, F. and McParland, V. and Müller, D. and Wilck, N. and Bartolomaeus, H. and Holle, J.
Molecular and Cellular Pediatrics 8 (1): 17. 22 October 2021

The ubiquitin-proteasome system and autophagy: self-digestion for metabolic health.
Sun-Wang, J.L. and Yarritu-Gallego, A. and Ivanova, S. and Zorzano, A.
Trends in Endocrinology and Metabolism 32 (8): 594-608. August 2021

The gut microbiome in hypertension: recent advances and future perspectives.
Avery, E.G. and Bartolomaeus, H. and Maifeld, A. and Marko, L. and Wiig, H. and Wilck, N. and Rosshart, S.P. and Forslund, S.K. and Muller, D.N.
Circulation Research 128 (7): 934-950. 2 April 2021

Ernährung und Hypertonie : Worauf man neben der medikamentösen Therapie achten sollte [Nutrition and hypertension : what one should pay attention to in addition to the pharmaceutical treatment].
McParland, V. and Wilck, N.
Internist 62 (3): 269-276. March 2021

The role of the gut microbiota and microbial metabolites in neuroinflammation.
Haase, S. and Wilck, N. and Haghikia, A. and Gold, R. and Mueller, D.N. and Linker, R.A.
European Journal of Immunology 50 (12): 1863-1870. December 2020

The role of sodium in modulating immune cell function.
Wilck, N. and Balogh, A. and Markó, L. and Bartolomaeus, H. and Müller, D.N.
Nature Reviews Nephrology 15 (9): 546-558. September 2019

Sodium chloride triggers Th17 mediated autoimmunity.
Haase, S. and Wilck, N. and Kleinewietfeld, M. and Müller, D.N. and Linker, R.A.
Journal of Neuroimmunology 329 : 9-13. 15 April 2019

Sodium in the microenvironment regulates immune responses and tissue homeostasis.
Müller, D.N. and Wilck, N. and Haase, S. and Kleinewietfeld, M. and Linker, R.A.
Nature Reviews Immunology 19 (4): 243-254. April 2019

Letter

Myocardial evaluation of post-preeclamptic women by CMR: is early risk stratification possible?
Birukov, A. and Wiesemann, S. and Golic, M. and Balogh, A. and Marko, L. and Rakova, N. and Wilck, N. and Blaszczyk, E. and Lim, C. and Weiss, S. and Kräker, K. and Haase, N. and Frolova, A. and Jørgensen, J.S. and Daub, S. and Mueller, D.N. and Herse, F. and Schulz-Menger, J. and Dechend, R.
JACC: Cardiovascular Imaging 13 (5): 1291-1293. May 2020

Editorial

What's for dinner? Why a close look at diet and microbiota is worthwhile in experimental hypertension research.
Wilck, N.
Acta Physiologica 232 (4): e13704. August 2021

Blood pressure changes correlate with short-chain fatty acid production potential shifts under a synbiotic intervention.
Bartolomaeus, H. and Avery, E.G. and Bartolomaeus, T.U.P. and Kozhakhmetov, S. and Zhumadilov, Z. and Müller, D.N. and Wilck, N. and Kushugulova, A. and Forslund, S.K.
Cardiovascular Research 116 (7): 1252-1253. June 2020

Precarious symbiosis between host and microbiome in cardiovascular health.
Bartolomaeus, H. and Markó, L. and Wilck, N. and Luft, F.C. and Forslund, S.K. and Muller, D.N.
Hypertension 73 (5): 926-935. May 2019

Preprint

Fasting alters the gut microbiome with sustained blood pressure and body weight reduction in metabolic syndrome patients.
Balogh, A. and Bartolomaeus, H. and Löber, U. and Avery, E.G. and Steckhan, N. and Markó, L. and Wilck, N. and Hamad, I. and Šušnjar, U. and Mähler, A. and Hohmann, C. and Cramer, H. and Dobos, G. and Lesker, T.R. and Strowig, T. and Dechend, R. and Bzdok, D. and Kleinewietfeld, M. and Michalsen, A. and Müller, D.N. and Forslund, S.K.
medRxiv : 2020.02.23.20027029. 25 February 2020