Browse by Research Team

Acta Physiologica

Metformin modulates microbiota and improves blood pressure and cardiac remodeling in a rat model of hypertension.
Wimmer, M.I., Bartolomaeus, H., Anandakumar, H., Chen, C.Y., Vecera, V., Kedziora, S., Kamboj, S., Schumacher, F., Pals, S., Rauch, A., Meisel, J., Potapenko, O., Yarritu, A., Bartolomaeus, T.U.P., Samaan, M., Thiele, A., Stürzbecher, L., Geisberger, S.Y., Kleuser, B., Oefner, P.J., Haase, N., Löber, U., Gronwald, W., Forslund-Startceva, S.K., Müller, D.N. and Wilck, N.
Acta Physiologica 240 (11): e14226. November 2024

What's for dinner? Why a close look at diet and microbiota is worthwhile in experimental hypertension research.
Wilck, N.
Acta Physiologica 232 (4): e13704. August 2021

Advances in Experimental Medicine and Biology

Associations of the adaptive immune system and age-related macular degeneration.
Stürzbecher, L. and Strauss, O.
In: International Workshop on Ambient Assisted Living - IWAAL 2011, 08-11 Jun 2011, Torremolinos, Spain. 11 February 2025

American Journal of Transplantation

Gut microbiome alterations precede graft rejection in kidney transplantation patients.
Holle, J., Reitmeir, R., Behrens, F., Singh, D., Schindler, D., Potapenko, O., McParland, V., Anandakumar, H., Kanzelmeyer, N., Sommerer, C., Hartleif, S., Andrassy, J., Heemann, U., Neuenhahn, M., Forslund-Startceva, S.K., Gerhard, M., Oh, J., Wilck, N., Löber, U. and Bartolomaeus, H.
American Journal of Transplantation 18 February 2025 (In Press)

Basic Research in Cardiology

Assessing customized multivalent chemokine-binding peptide treatment in a murine model of coxsackievirus B3 myocarditis.
Kelm, N., Kespohl, M., Smagurauskaite, G., Vales, S., Karuppanan, K., Mburu, P., Thiele, A., Pinkert, S., Bukur, T., Mülleder, M., Berndt, N., Klingel, K., Gaida, M.M., Bhattacharya, S. and Beling, A.
Basic Research in Cardiology 120 (2): 393-422. April 2025

Characterization of anthracycline-induced cardiotoxicity by diffusion tensor magnetic resonance imaging.
Lohr, D., Thiele, A., Stahnke, M., Braun, V.M., Klopfleisch, R., Klein, O., Dresen, S., Landmesser, U., Foryst-Ludwig, A., Kintscher, U., Schreiber, L.M. and Beyhoff, N.
Basic Research in Cardiology 120 (1): 57-69. February 2025

Biomedicines

G(q)-mediated arrhythmogenic signaling promotes atrial fibrillation.
Hohendanner, F., Prabhu, A., Wilck, N., Stangl, V., Pieske, B., Stangl, K. and Althoff, T.F.
Biomedicines 11 (2): 526. 11 February 2023

Cardiovascular Research

A novel approach to modelling acute cardiac decompensation in rats.
Thiele, A., Bartolomaeus, H., Anandakumar, H., Haase, N., Heuser, A., Müller, D.N., Dechend, R. and Wilck, N.
Cardiovascular Research 121 (3): cvae268. February 2025

Intestinal interstitial fluid isolation provides novel insight into the human host-microbiome interface.
Avery, E.G., Haag, L.M., McParland, V., Kedziora, S.M., Zigra, G.J., Valdes, D.S., Kirchner, M., Popp, O., Geisberger, S., Nonn, O., Karlsen, T.V., N'Diaye, G., Yarritu, A., Bartolomaeus, H., Bartolomaeus, T.U.P., Tagiyeva, N.A., Wimmer, M.I., Haase, N., Zhang, Y.D., Wilhelm, A., Grütz, G., Tenstad, O., Wilck, N., Forslund, S.K., Klopfleisch, R., Kühl, A.A., Atreya, R., Kempa, S., Mertins, P., Siegmund, B., Wiig, H. and Müller, D.N.
Cardiovascular Research : cvae267. 13 January 2025 (In Press)

Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage.
Avery, E.G., Bartolomaeus, H., Rauch, A., Chen, C.Y., N'Diaye, G., Löber, U., Bartolomaeus, T.U.P., Fritsche-Guenther, R., Rodrigues, A.F., Yarritu, A., Zhong, C., Fei, L., Tsvetkov, D., Todiras, M., Park, J.K., Markó, L., Maifeld, A., Patzak, A., Bader, M., Kempa, S., Kirwan, J.A., Forslund, S.K., Müller, D.N. and Wilck, N.
Cardiovascular Research 119 (6): 1441-1452. May 2023

Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications.
Gawałko, M., Agbaedeng, T.A., Saljic, A., Mueller, D.N., Wilck, N., Schnabel, R., Penders, J., Rienstra, M., van Gelder, I., Jespersen, T., Schotten, U., Crijns, H.J.G.M., Kalman, J.M., Sanders, P., Nattel, S., Dobrev, D. and Linz, D.
Cardiovascular Research 118 (11): 2415–2427. July 2022

Pharmacological inhibition of adipose tissue Adipose Triglyceride Lipase (ATGL) by Atglistatin prevents catecholamine-induced myocardial damage.
Thiele, A., Luettges, K., Ritter, D., Beyhoff, N., Smeir, E., Grune, J., Steinhoff, J.S., Schupp, M., Klopfleisch, R., Rothe, M., Wilck, N., Bartolomaeus, H., Migglautsch, A.K., Breinbauer, R., Kershaw, E.E., Grabner, G.F., Zechner, R., Kintscher, U. and Foryst-Ludwig, A.
Cardiovascular Research 118 (11): 2488-2505. July 2022

Quantifying technical confounders in microbiome studies.
Bartolomaeus, T.U.P., Birkner, T., Bartolomaeus, H., Löber, U., Avery, E.G., Mähler, A., Weber, D., Kochlik, B., Balogh, A., Wilck, N., Boschmann, M., Müller, D.N., Markó, L. and Forslund, S.K.
Cardiovascular Research 117 (3): 863-875. 1 March 2021

Blood pressure changes correlate with short-chain fatty acid production potential shifts under a synbiotic intervention.
Bartolomaeus, H., Avery, E.G., Bartolomaeus, T.U.P., Kozhakhmetov, S., Zhumadilov, Z., Müller, D.N., Wilck, N., Kushugulova, A. and Forslund, S.K.
Cardiovascular Research 116 (7): 1252-1253. June 2020

B-cell lymphoma/leukemia 10 and angiotensin II-induced kidney injury.
Markó, L., Park, J.K., Henke, N., Rong, S., Balogh, A., Klamer, S., Bartolomaeus, H., Wilck, N., Ruland, J., Forslund, S.K., Luft, F.C., Dechend, R. and Müller, D.N.
Cardiovascular Research 116 (5): 1059-1070. 1 April 2020

Cell Metabolism

Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs.
Côrte-Real, B.F., Hamad, I., Arroyo Hornero, R., Geisberger, S., Roels, J., Van Zeebroeck, L., Dyczko, A., van Gisbergen, M.W., Kurniawan, H., Wagner, A., Yosef, N., Weiss, S.N.Y., Schmetterer, K.G., Schröder, A., Krampert, L., Haase, S., Bartolomaeus, H., Hellings, N., Saeys, Y., Dubois, L.J., Brenner, D., Kempa, S., Hafler, D.A., Stegbauer, J., Linker, R.A., Jantsch, J., Müller, D.N. and Kleinewietfeld, M.
Cell Metabolism 35 (2): 299-315. 7 February 2023

Circulation

Salt transiently inhibits mitochondrial energetics in mononuclear phagocytes.
Geisberger, S., Bartolomaeus, H., Neubert, P., Willebrand, R., Zasada, C., Bartolomaeus, T., McParland, V., Swinnen, D., Geuzens, A., Maifeld, A., Krampert, L., Vogl, M., Mähler, A., Wilck, N., Marko, L., Tilic, E., Forslund, S.K., Binger, K.J., Stegbauer, J., Dechend, R., Kleinewietfeld, M., Jantsch, J., Kempa, S. and Müller, D.N.
Circulation 144 (2): 144-158. 13 July 2021

Natural compound library screening identifies new molecules for the treatment of cardiac fibrosis and diastolic dysfunction.
Schimmel, K., Jung, M., Foinquinos, A., San José, G., Beaumont, J., Bock, K., Grote-Levi, L., Xiao, K., Bär, C., Pfanne, A., Just, A., Zimmer, K., Ngoy, S., López, B., Ravassa, S., Samolovac, S., Janssen-Peters, H., Remke, J., Scherf, K., Dangwal, S., Piccoli, M.T., Kleemiss, F., Kreutzer, F.P., Kenneweg, F., Leonardy, J., Hobuß, L., Santer, L., Do, Q.T., Geffers, R., Braesen, J.H., Schmitz, J., Brandenberger, C., Müller, D.N., Wilck, N., Kaever, V., Bähre, H., Batkai, S., Fiedler, J., Alexander, K.M., Wertheim, B.M., Fisch, S., Liao, R., Diez, J., González, A. and Thum, T.
Circulation 141 (9): 751-767. 3 March 2020

Short-chain fatty acid propionate protects from hypertensive cardiovascular damage.
Bartolomaeus, H., Balogh, A., Yakoub, M., Homann, S., Markó, L., Höges, S., Tsvetkov, D., Krannich, A., Wundersitz, S., Avery, E.G., Haase, N., Kräker, K., Hering, L., Maase, M., Kusche-Vihrog, K., Grandoch, M., Fielitz, J., Kempa, S., Gollasch, M., Zhumadilov, Z., Kozhakhmetov, S., Kushugulova, A., Eckardt, K.U., Dechend, R., Rump, L.C., Forslund, S.K., Müller, D.N., Stegbauer, J. and Wilck, N.
Circulation 139 (11): 1407-1421. 12 March 2019

Circulation Research

The gut microbiome in hypertension: recent advances and future perspectives.
Avery, E.G., Bartolomaeus, H., Maifeld, A., Marko, L., Wiig, H., Wilck, N., Rosshart, S.P., Forslund, S.K. and Muller, D.N.
Circulation Research 128 (7): 934-950. 2 April 2021

Clinical Kidney Journal

Gut-immune axis and cardiovascular risk in chronic kidney disease.
Behrens, F., Bartolomaeus, H., Wilck, N. and Holle, J.
Clinical Kidney Journal 17 (1): sfad303. January 2024

Dialyse aktuell

Der Einfluss der Mikrobiota auf den Blutdruck : Wie Darmbakterien Bluthochdruck und Organschäden beeinflussen.
Wilck, N.
Dialyse aktuell 24 (9): 360-366. November 2020

European Journal of Immunology

The role of the gut microbiota and microbial metabolites in neuroinflammation.
Haase, S., Wilck, N., Haghikia, A., Gold, R., Mueller, D.N. and Linker, R.A.
European Journal of Immunology 50 (12): 1863-1870. December 2020

FASEB Journal

Deletion in mice of X-linked, Brugada syndrome- and atrial fibrillation-associated Kcne5 augments ventricular K(V) currents and predisposes to ventricular arrhythmia.
David, J.P., Lisewski, U., Crump, S.M., Jepps, T.A., Bocksteins, E., Wilck, N., Lossie, J., Roepke, T.K., Schmitt, N. and Abbott, G.W.
FASEB Journal 33 (2): 2537-2552. February 2019

Frontiers in Bioscience

Anti-β1-adrenoreceptor auto-antibodies in elderly heart failure patients.
Trippel, T.D., Mueller, D.N., Obradovic, D., Edelmann, F., Tahirovic, E., Wilck, N., Riemekasten, G., Dragun, D., Busjahn, A., Heidecke, H., Junker, J., Pieske, B., Dungen, H.D. and Dechend, R.
Frontiers in Bioscience 24 : 1037-1049. 1 March 2019

Frontiers in Immunology

Outer retina micro-inflammation is driven by T cell responses prior to retinal degeneration in early age-related macular degeneration.
Stürzbecher, L., Bartolomaeus, H., Bartolomaeus, T.U.P., Bolz, S., Sekulic, A., Ueffing, M., Clark, S.J., Reichhart, N., Crespo-Garcia, S., Wilck, N. and Strauß, O.
Frontiers in Immunology 16 : 1520188. 5 February 2025

Gut Microbes

Segmental patterning of microbiota and immune cells in the murine intestinal tract.
Anandakumar, H., Rauch, A., Wimmer, M.I., Yarritu, A., Koch, G., McParland, V., Bartolomaeus, H. and Wilck, N.
Gut Microbes 16 (1): 2398126. 2024

Hernia

Medium term (> 12 months) outcomes after laparoscopic hiatal hernia repair without conventional fundoplication using PH4B‑mesh implant (Phasix™) in 176 reflux patients: experience and technique.
Siemssen, B., Dahlke, P.M., Behrens, F., Hentschel, F. and Ibach, M.J.
Hernia 28 (5): 1641-1647. October 2024

Herz

Darm-Herz-Achse: Wie Darmbakterien kardiovaskuläre Erkrankungen beeinflussen [Gut-heart axis: how gut bacteria influence cardiovascular diseases].
Bartolomaeus, H., McParland, V. and Wilck, N.
Herz 45 (2): 134-141. April 2020

Hypertension

Sodium as an important regulator of immunometabolism.
Miyauchi, H., Geisberger, S., Luft, F.C., Wilck, N., Stegbauer, J., Wiig, H., Dechend, R., Jantsch, J., Kleinewietfeld, M., Kempa, S. and Mueller, D.N.
Hypertension 81 (3): 426-435. March 2024

Precarious symbiosis between host and microbiome in cardiovascular health.
Bartolomaeus, H., Markó, L., Wilck, N., Luft, F.C., Forslund, S.K. and Muller, D.N.
Hypertension 73 (5): 926-935. May 2019

Internist

Ernährung und Hypertonie : Worauf man neben der medikamentösen Therapie achten sollte [Nutrition and hypertension : what one should pay attention to in addition to the pharmaceutical treatment].
McParland, V. and Wilck, N.
Internist 62 (3): 269-276. March 2021

JACC: Cardiovascular Imaging

Myocardial evaluation of post-preeclamptic women by CMR: is early risk stratification possible?
Birukov, A., Wiesemann, S., Golic, M., Balogh, A., Marko, L., Rakova, N., Wilck, N., Blaszczyk, E., Lim, C., Weiss, S., Kräker, K., Haase, N., Frolova, A., Jørgensen, J.S., Daub, S., Mueller, D.N., Herse, F., Schulz-Menger, J. and Dechend, R.
JACC: Cardiovascular Imaging 13 (5): 1291-1293. May 2020

Journal of Extracellular Vesicles

Circulating extracellular vesicles as putative mediators of cardiovascular disease in paediatric chronic kidney disease.
Behrens, F., Holle, J., Chen, C.Y., Ginsbach, L.F., Krause, B.C., Bruning, U., Kriegel, F.L., Kaiser, T., Szijártó, I.A., Anandakumar, H., Lehmann, K., Schumacher, F., Durek, P., Heinrich, F.F., Lodka, D., Hoffmann, C., Borchardt, A.A., Peters, L., Michalick, L., Querfeld, U., Bufler, P., Luch, A., Kleuser, B., Kirwan, J.A., Forslund, S.K., Thumfahrt, J., Müller, D., Wilck, N., Mashreghi, M.F., Löber, U., Bartolomaeus, H., Kuebler, W.M. and Simmons, S.
Journal of Extracellular Vesicles 14 (3): e70062. March 2025

Journal of Investigative Dermatology

Skin sodium accumulates in psoriasis and reflects disease severity.
Maifeld, A., Wild, J., Karlsen, T.V., Rakova, N., Wistorf, E., Linz, P., Jung, R., Birukov, A., Gimenez-Rivera, V.A., Wilck, N., Bartolomaeus, T., Dechend, R., Kleinewietfeld, M., Forslund, S.K., Krause, A., Kokolakis, G., Philipp, S., Clausen, B.E., Brand, A., Waisman, A., Kurschus, F.C., Wegner, J., Schultheis, M., Luft, F.C., Boschmann, M., Kelm, M., Wiig, H., Kuehne, T., Müller, D.N., Karbach, S. and Markó, L.
Journal of Investigative Dermatology 142 (1): 166-178. January 2022

Journal of Neuroimmunology

Sodium chloride triggers Th17 mediated autoimmunity.
Haase, S., Wilck, N., Kleinewietfeld, M., Müller, D.N. and Linker, R.A.
Journal of Neuroimmunology 329 : 9-13. 15 April 2019

Journal of the American Society of Nephrology

Inflammation in children with chronic kidney disease linked to gut dysbiosis and metabolite imbalance.
Holle, J., Bartolomaeus, H., Löber, U., Behrens, F., Bartolomaeus, T.U.P., Anandakumar, H., Wimmer, M., Vu, D.L., Kuhring, M., Brüning, U., Maifeld, A., Geisberger, S., Kempa, S., Schumacher, F., Kleuser, B., Bufler, P., Querfeld, U., Kitschke, S., Engler, D., Kuhrt, L.D., Drechsel, O., Eckardt, K.U., Forslund, S., Thürmer, A., McParland, V., Kirwan, J., Wilck, N. and Mueller, D.
Journal of the American Society of Nephrology 33 (12): 2259-2275. December 2022

Kidney International

Trends and perspectives for improving quality of chronic kidney disease care: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.
Eckardt, K.U., Delgado, C., Heerspink, H.J.L., Pecoits-Filho, R., Ricardo, A.C., Stengel, B., Tonelli, M., Cheung, M., Jadoul, M., Winkelmayer, W.C. and Kramer, H.
Kidney International 104 (5): 888-903. November 2023

Molecular and Cellular Pediatrics

Bacterial metabolites and cardiovascular risk in children with chronic kidney disease.
Schlender, J., Behrens, F., McParland, V., Müller, D., Wilck, N., Bartolomaeus, H. and Holle, J.
Molecular and Cellular Pediatrics 8 (1): 17. 22 October 2021

Nature Communications

Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung.
Dörner, P.J., Anandakumar, H., Röwekamp, I., Fiocca Vernengo, F., Millet Pascual-Leone, B., Krzanowski, M., Sellmaier, J., Brüning, U., Fritsche-Guenther, R., Pfannkuch, L., Kurth, F., Milek, M., Igbokwe, V., Löber, U., Gutbier, B., Holstein, M., Heinz, G.A., Mashreghi, M.F., Schulte, L.N., Klatt, A.B., Caesar, S., Wienhold, S.M., Offermanns, S., Mack, M., Witzenrath, M., Jordan, S., Beule, D., Kirwan, J.A., Forslund, S.K., Wilck, N., Bartolomaeus, H., Heimesaat, M.M. and Opitz, B.
Nature Communications 15 (1): 2788. 30 March 2024

Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients.
Maifeld, A., Bartolomaeus, H., Löber, U., Avery, E.G., Steckhan, N., Markó, L., Wilck, N., Hamad, I., Šušnjar, U., Mähler, A., Hohmann, C., Chen, C.Y., Cramer, H., Dobos, G., Lesker, T.R., Strowig, T., Dechend, R., Bzdok, D., Kleinewietfeld, M., Michalsen, A., Müller, D.N. and Forslund, S.K.
Nature Communications 12 (1): 1970. 30 March 2021

Nature Reviews Immunology

Sodium in the microenvironment regulates immune responses and tissue homeostasis.
Müller, D.N., Wilck, N., Haase, S., Kleinewietfeld, M. and Linker, R.A.
Nature Reviews Immunology 19 (4): 243-254. April 2019

Nature Reviews Nephrology

The role of sodium in modulating immune cell function.
Wilck, N., Balogh, A., Markó, L., Bartolomaeus, H. and Müller, D.N.
Nature Reviews Nephrology 15 (9): 546-558. September 2019

Nephrologie

Diastolische Dysfunktion und HFpEF bei CKD: Ein Update [Diastolic dysfunction and HFpEF in CKD: An update].
Szijártó, I.A. and Wilck, N.
Nephrologie 18 : 361–369. November 2023

Nephrology Dialysis Transplantation

Gut dysbiosis contributes to TMAO accumulation in CKD.
Holle, J., McParland, V., Anandakumar, H., Gerritzmann, F., Behrens, F., Schumacher, F., Thumfart, J., Eckardt, K.U., Kleuser, B., Bartolomaeus, H. and Wilck, N.
Nephrology Dialysis Transplantation 39 (11): 1923-1926. November 2024

Nutrients

Increased salt intake decreases diet-induced thermogenesis in healthy volunteers: a randomized placebo-controlled study.
Mähler, A., Klamer, S., Maifeld, A., Bartolomaeus, H., Markó, L., Chen, C.Y., Forslund, S.K., Boschmann, M., Müller, D.N. and Wilck, N.
Nutrients 14 (2): 253. 7 January 2022

Pediatric Nephrology

Gut-derived metabolites as treatment targets in chronic kidney disease - an avenue toward personalized medicine.
Holle, J. and Bartolomaeus, H.
Pediatric Nephrology 40 (5): 1505-1510. May 2025

Trends in Endocrinology and Metabolism

The ubiquitin-proteasome system and autophagy: self-digestion for metabolic health.
Sun-Wang, J.L., Yarritu-Gallego, A., Ivanova, S. and Zorzano, A.
Trends in Endocrinology and Metabolism 32 (8): 594-608. August 2021

Trials

IA-PACS-CFS: a double-blinded, randomized, sham-controlled, exploratory trial of immunoadsorption in patients with chronic fatigue syndrome (CFS) including patients with post-acute COVID-19 CFS (PACS-CFS).
Preßler, H., Machule, M.L., Ufer, F., Bünger, I., Li, L.Y., Buchholz, E., Werner, C., Beraha, E., Wagner, F., Metz, M., Burock, S., Bruckert, L., Franke, C., Wilck, N., Krüger, A., Reshetnik, A., Eckardt, K.U., Endres, M. and Prüss, H.
Trials 25 (1): 172. 7 March 2024

Effect of a probiotic on blood pressure in grade 1 hypertension (HYPRO): protocol of a randomized controlled study.
Mähler, A., Wilck, N., Rauch, G., Dechend, R. and Müller, D.N.
Trials 21 (1): 1032. 29 December 2020

bioRxiv

Baseline microbiome composition impacts resilience to and recovery following antibiotics.
Chen, C.Y., Löber, U., Bartolomaeus, H., Maier, L., Müller, D.N., Wilck, N., Jarquín-Díaz, V.H. and Forslund-Startceva, S.K.
bioRxiv : 2024.03.31.587491. 31 March 2024