Browse by Research Team

2017

In colon epithelia, Clostridium perfringens enterotoxin causes focal leaks by targeting claudins which are apically accessible due to tight junction derangement.
Eichner, M., Augustin, C., Fromm, A., Piontek, A., Walther, W., Buecker, R., Fromm, M., Krause, G., Schulzke, J.D., Guenzel, D. and Piontek, J.
Journal of Infectious Diseases 217 (1): 147-157. 27 December 2017

Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1.
Juneja, M., Kobelt, D., Walther, W., Voss, C., Smith, J., Specker, E., Neuenschwander, M., Gohlke, B.O., Dahlmann, M., Radetzki, S., Preissner, R., von Kries, J.P., Schlag, P.M. and Stein, U.
PLoS Biology 15 (6): e2000784. 1 June 2017

Choosing wisely - Preclinical test models in the era of precision medicine.
Klinghammer, K., Walther, W. and Hoffmann, J.
Cancer Treatment Reviews 55 : 36-45. April 2017

In vitro and in vivo investigations into the carbene gold chloride and thioglucoside anticancer drug candidates NHC-AuCl and NHC-AuSR.
Walther, W., Dada, O., O’Beirne, C., Ott, I., Sanchez-Sanz, G., Schmidt, C., Werner, C., Zhu, X. and Tacke, M.
Letters in Drug Design & Discovery 14 (2): 125-134. 2017

2016

SPON2, a newly identified target gene of MACC1, drives colorectal cancer metastasis in mice and is prognostic for colorectal cancer patient survival.
Schmid, F., Wang, Q., Huska, M.R., Andrade-Navarro, M.A., Lemm, M., Fichtner, I., Dahlmann, M., Kobelt, D., Walther, W., Smith, J., Schlag, P.M. and Stein, U.
Oncogene 35 (46): 5942-5952. 17 November 2016

Vectors and strategies for nonviral cancer gene therapy.
Pahle, J. and Walther, W.
Expert Opinion on Biological Therapy 16 (4): 443-461. April 2016

Current strategies in cancer gene therapy.
Walther, W., ed.
Recent Results in Cancer Research, 209 . Springer. ISBN 978-3-319-42932-8 2016

2015

Chemosensitization by diverging modulation by short-term and long-term TNF-α action on ABCB1 expression and NF-κB signaling in colon cancer.
Walther, W., Kobelt, D., Bauer, L., Aumann, J. and Stein, U.
International Journal of Oncology 47 (6): 2276-2285. December 2015

Oncoleaking: use of the pore-forming clostridium perfringens enterotoxin (CPE) for suicide gene therapy.
Pahle, J., Aumann, J., Kobelt, D. and Walther, W.
Methods in Molecular Biology 1317 : 69-85. 2015

2014

In vitro and in vivo investigations into the carbene copper bromide anticancer drug candidate WBC4.
Walther, W., Fichtner, I., Hackenberg, F., Streciwilk, W. and Tacke, M.
Letters in Drug Design & Discovery 11 (7): 825-832. August 2014

Preclinical study on combined chemo- and nonviral gene therapy for sensitization of melanoma using a human TNF-alpha expressing MIDGE DNA vector.
Kobelt, D., Aumann, J., Schmidt, M., Wittig, B., Fichtner, I., Behrens, D., Lemm, M., Freundt, G., Schlag, P.M. and Walther, W.
Molecular Oncology 8 (3): 609-619. May 2014

2013

A seven-year storage report of good manufacturing practice-grade naked plasmid DNA: stability, topology, and in vitro/in vivo functional analysis.
Walther, W., Schmeer, M., Kobelt, D., Baier, R., Harder, A., Walhorn, V., Anselmetti, D., Aumann, J., Fichtner, I. and Schleef, M.
Human Gene Therapy Clinical Development 24 (4): 147-153. December 2013

Current status of gene therapy for cancer.
Walther, W. and Schlag, P.M.
Current Opinion in Oncology 25 (6): 659-664. November 2013

The activity of titanocene T against xenografted Caki-1 tumors.
Walther, W., Fichtner, I., Deally, A., Hogan, M. and Tacke, M.
Letters in Drug Design & Discovery 10 (5): 375-381. June 2013

Minicircle-based vectors for nonviral gene therapy: in vitro characterization and in vivo application.
Kobelt, D., Aumann, J., Schleef, M., Schmeer, M., Stein, U., Schlag, P.M. and Walther, W.
In: Minicircle and miniplasmid DNA vectors: the future of nonviral and viral gene transfer. Wiley, 177-188. ISBN 978-3-527-32456-9 17 April 2013

Performance of high quality minicircle DNA for in vitro and in vivo gene transfer.
Kobelt, D., Schleef, M., Schmeer, M., Aumann, J., Schlag, P.M. and Walther, W.
Molecular Biotechnology 53 (1): 80-89. January 2013

2012

HER2/neu DNA vaccination by intradermal gene delivery in a mouse tumor model: gene gun is superior to jet injector in inducing CTL responses and protective immunity.
Nguyen-Hoai, T., Kobelt, D., Hohn, O., Vu, M.D., Schlag, P.M., Doerken, B., Norley, S., Lipp, M., Walther, W., Pezzutto, A. and Westermann, J.
OncoImmunology 1 (9): 1537-1545. 1 December 2012

In vivo imaging of colorectal cancer growth and metastasis by targeting MACC1 with shRNA in xenografted mice.
Pichorner, A., Sack, U., Kobelt, D., Kelch, I., Arlt, F., Smith, J., Walther, W., Schlag, P.M. and Stein, U.
Clinical and Experimental Metastasis 29 (6): 573-583. August 2012

Intratumoral dispersion, retention, systemic biodistribution, and clearance of a small-size tumor necrosis factor-α-expressing MIDGE vector after nonviral in vivo jet-injection gene transfer.
Galling, N., Kobelt, D., Aumann, J., Schmidt, M., Wittig, B., Schlag, P.M. and Walther, W.
Human Gene Therapy Part B Methods 23 (4): 264-270. August 2012

Novel Clostridium perfringens enterotoxin suicide gene therapy for selective treatment of claudin-3- and -4-overexpressing tumors.
Walther, W., Petkov, S., Kuvardina, O.N., Aumann, J., Kobelt, D., Fichtner, I., Lemm, M., Piontek, J., Blasig, I.E., Stein, U. and Schlag, P.M.
Gene Therapy 19 (5): 494-503. May 2012

Impact of mutant beta-catenin on ABCB1 expression and therapy response in colon cancer cells.
Stein, U., Fleuter, C., Siegel, F., Smith, J., Kopacek, A., Scudiero, D.A., Hite, K.M., Schlag, P.M., Shoemaker, R.H. and Walther, W.
British Journal of Cancer 106 (8): 1395-1405. 10 April 2012

2011

S100A4-induced cell motility and metastasis is restricted by the Wnt/β-catenin pathway inhibitor calcimycin in colon cancer cells.
Sack, U., Walther, W., Scudiero, D., Selby, M., Aumann, J., Lemos, C., Fichtner, I., Schlag, P.M., Shoemaker, R.H. and Stein, U.
Molecular Biology of the Cell 22 (18): 3344-3354. September 2011

Novel effect of antihelminthic niclosamide on S100A4-mediated metastatic progression in colon cancer.
Sack, U., Walther, W., Scudiero, D., Selby, M., Kobelt, D., Lemm, M., Fichtner, I., Schlag, P.M., Shoemaker, R.H. and Stein, U.
Journal of the National Cancer Institute 103 (13): 1018-1036. 6 July 2011

Intervening in beta-catenin signaling by sulindac inhibits S100A4-dependent colon cancer metastasis.
Stein, U., Arlt, F., Smith, J., Sack, U., Herrmann, P., Walther, W., Lemm, M., Fichtner, I., Shoemaker, R.H. and Schlag, P.M.
Neoplasia 13 (2): 131-144. February 2011

2010

Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells.
Juerchott, K., Kuban, R.J., Krech, T., Blüthgen, N., Stein, U., Walther, W., Friese, C., Kielbasa, S.M., Ungethuem, U., Lund, P., Knoesel, T., Kemmner, W., Morkel, M., Fritzmann, J., Schlag, P.M., Birchmeier, W., Krueger, T., Sperling, S., Sers, C., Royer, H.D., Herzel, H. and Schaefer, R.
PLoS Genetics 6 (12): e1001231. 2 December 2010

Activation of the CMV-IE promoter by hyperthermia in vitro and in vivo: biphasic heat induction of cytosine deaminase suicide gene expression.
Kobelt, D., Aumann, J., Fichtner, I., Stein, U., Schlag, P.M. and Walther, W.
Molecular Biotechnology 46 (2): 197-205. October 2010

MACC1 - more than metastasis? Facts and predictions about a novel gene.
Stein, U., Dahlmann, M. and Walther, W.
Journal of Molecular Medicine 88 (1): 11-18. January 2010

Jet-injection of short hairpin RNA-encoding vectors into tumor cells.
Walther, W., Stein, U. and Lage, H.
Methods in Molecular Biology 629 : 123-139. 2010

2009

MACC1 controls Met: What a difference an Sp1 site makes.
Stein, U., Smith, J., Walther, W. and Arlt, F.
Cell Cycle 8 (15): 2467-2469. 1 August 2009

Heat-responsive gene expression for gene therapy.
Walther, W. and Stein, U.
Advanced Drug Delivery Reviews 61 (7-8): 641-649. 2 July 2009

MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis.
Stein, U., Walther, W., Arlt, F., Schwabe, H., Smith, J., Fichtner, I., Birchmeier, W. and Schlag, P.M.
Nature Medicine 15 (1): 59-67. January 2009

Nonviral jet-injection technology for intratumoral in vivo gene transfer of naked DNA.
Walther, W., Fichtner, I., Schlag, P.M. and Stein, U.S.
Methods in Molecular Biology 542 : 195-208. 2009

2008

Novel jet-injection technology for nonviral intratumoral gene transfer in patients with melanoma and breast cancer.
Walther, W., Siegel, R., Kobelt, D., Knoesel, T., Dietel, M., Bembenek, A., Aumann, J., Schleef, M., Baier, R., Stein, U. and Schlag, P.M.
Clinical Cancer Research 14 (22): 7545-7553. 15 November 2008

Complete in vivo reversal of the multidrug resistance phenotype by jet-injection of anti-MDR1 short hairpin RNA-encoding plasmid DNA.
Stein, U., Walther, W., Stege, A., Kaszubiak, A., Fichtner, I. and Lage, H.
Molecular Therapy 16 (1): 178-186. January 2008

Lokale nicht-virale Gentherapie in kutanen Metastasen von Mammakarzinom und Melanom: Ergebnisse einer Phase-I-Studie mittels Jet-Injektion nackter DNA.
Siegel, R., Kobelt, D., Knoesel, T., Stein, U., Schlag, P.M. and Walther, W.
Chirurgisches Forum 2008 37 : 131-132. 2008

2007

Heat-inducible in vivo gene therapy of colon carcinoma by human mdr1 promoter-regulated tumor necrosis factor-alpha expression.
Walther, W., Arlt, F., Fichtner, I., Aumann, J., Stein, U. and Schlag, P.M.
Molecular Cancer Therapeutics 6 (1): 236-243. January 2007

2006

The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor (TCF) signaling in colon cancer.
Stein, U., Arlt, F., Walther, W., Smith, J., Waldman, T., Harris, E.D., Mertins, S.D., Heizmann, C.W., Allard, D., Birchmeier, W., Schlag, P.M. and Shoemaker, R.H.
Gastroenterology 131 (5): 1486-1500. November 2006

Reversal of ABC transporter-dependent multidrug resistance in cancer: A realistic option?
Stein, U. and Walther, W.
American Journal of Cancer 5 (5): 285-297. September 2006

Uptake, biodistribution, and time course of naked plasmid DNA trafficking after intratumoral in vivo jet injection.
Walther, W., Minow, T., Martin, R., Fichtner, I., Schlag, P.M. and Stein, U.
Human Gene Therapy 17 (6): 611-624. 15 June 2006

"Multidrug-Resistenz". Zellulaere Transportprobleme und ihre Konsequenzen ["Multidrug resistance". Cellular transport problems and their consequences].
Stein, U., Walther, W. and Schlag, P.M.
Paediatrische Praxis 68 : 11-19. 1 January 2006

2005

Nonviral jet-injection gene transfer for efficient in vivo cytosine deaminase suicide gene therapy of colon carcinoma.
Walther, W., Stein, U., Fichtner, I., Kobelt, D., Aumann, J., Arlt, F. and Schlag, P.M.
Molecular Therapy 12 (6): 1176-1184. 29 September 2005

Needleless jet injection of naked DNA for nonviral in vivo gene transfer.
Walther, W. and Stein, U.
In: DNA-Pharmaceuticals: Formulation and Delivery in Gene Therapy, DNA Vaccination and Immunotherapy. Wiley-VCH, 133-143. ISBN 9783527311873 25 August 2005

"Multidrug-Resistenz". Zellulaere Transportprobleme und ihre Konsequenzen ["Multidrug resistance". Cellular transport problems and their consequences].
Stein, U., Walther, W. and Schlag, P.M.
Taegliche Praxis 46 (1): 125-133. 1 January 2005

Use of the nuclease inhibitor aurintricarboxylic acid (ATA) for improved non-viral intratumoral in vivo gene transfer by jet-injection.
Walther, W., Stein, U., Siegel, R., Fichtner, I. and Schlag, P.M.
Journal of Gene Medicine 7 (4): 477-485. 1 January 2005

YB-1 facilitates basal and 5-fluorouracil-inducible expression of the human major vault protein (MVP) gene.
Stein, U., Bergmann, S., Scheffer, G.L., Scheper, R.J., Royer, H.D., Schlag, P.M. and Walther, W.
Oncogene 24 (22): 3606-3618. 1 January 2005

2004

Low-volume jet injection for efficient nonviral in vivo gene transfer.
Walther, W., Stein, U., Fichtner, I. and Schlag, P.M.
Molecular Biotechnology 28 (2): 121-128. 1 January 2004

Reversal of P-glycoprotein mediated vincristine resistance of L1210/VCR cells by analogues of pentoxifylline - A QSAR study.
Kupsakova, I., Rybar, A., Docolomansky, P., Drobna, Z., Stein, U., Walther, W., Barancik, M. and Breier, A.
European Journal of Pharmaceutical Sciences 21 (2-3): 283-293. 1 January 2004

2003

Stability analysis for long-term storage of naked DNA: impact on nonviral in vivo gene transfer.
Walther, W., Stein, U., Voss, C., Schmidt, T., Schleef, M. and Schlag, P.M.
Analytical Biochemistry 318 (2): 230-235. 15 July 2003

Process for treating tumors with cytotoxic substances.
Stein, U., Walther, W. and Schlag, P.M.
US6,582,690. 24 June 2003

Lipoplexes with alkylphospholipid as new helper lipid for efficient in vitro and in vivo gene transfer in tumor therapy.
Zeisig, R., Ress, A., Fichtner, I. and Walther, W.
Cancer Gene Therapy 10 (4): 302-311. April 2003

Functional haplotypes of the RET proto-oncogene promoter are associated with Hirschsprung disease (HSCR).
Fitze, G., Appelt, H., Koenig, I.R., Goergens, H., Stein, U., Walther, W., Gossen, M., Schreiber, M., Ziegler, A., Roesner, D. and Schackert, H.K.
Human Molecular Genetics 12 (24): 3207-3214. 1 January 2003

YB-1 as a cell cycle-regulated transcription factor facilitating cyclin A and cyclin B1 gene expression.
Juerchott, K., Bergmann, S., Stein, U., Walther, W., Janz, M., Manni, I., Piaggio, G., Fietze, E., Dietel, M. and Royer, H.D.
Journal of Biological Chemistry 278 (30): 27988-27996. 1 January 2003

2002

Intratumoral low-volume jet-injection for efficient nonviral gene transfer.
Walther, W., Stein, U., Fichtner, I., Voss, C., Schmidt, T., Schleef, M., Nellessen, T. and Schlag, P.M.
Molecular Biotechnology 21 (2): 105-115. 1 June 2002

Verwendung des humanen LRP/MVP Promotors fuer einen Therapie-induzierbaren Vektor [Use of the human LRP/MVP promotor of a vector that can be induced by therapy].
Stein, U., Lange, C., Walther, W. and Schlag, P.M.
DE10055383A1 ; EP1332219 ; WO0238188. 29 May 2002

Pentoxifylline influences drug transport activity of P-glycoprotein and decreases mdr1 gene expression in multidrug resistant mouse leukemic L1210/VCR cells.
Drobna, Z., Stein, U., Walther, W., Barancik, M. and Breier, A.
General Physiology and Biophysics 21 (1): 103-109. March 2002

Impact of BCRP/MXR, MRP1 and MDR1/P-glycoprotein on thermoresistant variants of atypical and classical multidrug resistant cancer.
Stein, U., Lage, H., Jordan, A., Walther, W., Bates, S.E., Litman, T., Hohenberger, P. and Dietel, M.
International Journal of Cancer 97 (6): 751-760. 1 January 2002

Tumorgenese.
Schlag, P.M., Estevez-Schwarz, L., Kemmner, W., Schumacher, K. and Walther, W.
In: Chirurgische Onkologie. Thieme, Stuttgart [u.a.], 2-17. ISBN 3-13-126111-0 1 January 2002

Use of the human MDR1 promoter for heat-inducible expression of therapeutic genes.
Walther, W., Stein, U. and Schlag, P.M.
International Journal of Cancer 98 (2): 291-296. 1 January 2002

Strategien zur Gentherapie von Tumorerkrankungen [Gene therapy strategies for tumor diseases].
Walther, W., Stein, U. and Schlag, P.M.
Chirurgische Praxis 60 : 19-26. 2002

2001

Hyperthermia-induced nuclear translocation of transcription factor YB-1 leads to enhanced expression of multidrug resistance-related ABC transporters.
Stein, U., Juerchott, K., Walther, W., Bergmann, S., Schlag, P.M. and Royer, H.D.
Journal of Biological Chemistry 276 (30): 28562-28569. 1 January 2001

In vivo Gentransfer nackter DNA in xenotransplantierte Kolonkarzinome in der Nude Maus mit Hilfe der Jet-Injektion [In vivo gene transfer of naked DNA into xenotransplanted colon carcinoma by jet-injection].
Walther, W., Stein, U., Fichtner, I. and Schlag, P.M.
Chirurgisches Forum 30 : 69-72. 1 January 2001

Nonviral in vivo gene delivery into tumors using a novel low volume jet-injection technology.
Walther, W., Stein, U., Fichtner, I., Malcherek, L., Lemm, M. and Schlag, P.M.
Gene Therapy 8 (3): 173-180. 1 January 2001

2000

Cloning and initial analysis of the human multidrug resistance-related MVP/LRP gene promoter.
Lange, C., Walther, W., Schwabe, H. and Stein, U.
Biochemical and Biophysical Research Communications 278 (1): 125-133. 11 November 2000

In vivo gene transfer by low-volume jet injection.
Cartier, R., Ren, S.V., Walther, W., Stein, U., Lewis, A., Schlag, P.M., Li, M. and Furth, P.A.
Analytical Biochemistry 282 (2): 262-265. 1 July 2000

Mittel zum nichtviralen Transfer von DNS in eukaryotische Zellen.
Zeisig, R. and Walther, W.
DE19959690A1. 8 June 2000

mdr1 promoter-driven tumor necrosis factor-alpha expression for a chemotherapy-controllable combined in vivo gene therapy and chemotherapy of tumors.
Walther, W., Stein, U., Fichtner, I., Alexander, M., Shoemaker, R.H. and Schlag, P.M.
Cancer Gene Therapy 7 (6): 893-900. 1 June 2000

High-copy cDNA amplification of minimal total RNA quantities for gene expression analyses.
Schwabe, H., Stein, U. and Walther, W.
Molecular Biotechnology 14 (2): 165-172. 1 February 2000

Chemotherapy-inducible vector for gene therapy of cancer.
Walther, W., Stein, U., Shoemaker, R.H. and Schlag, P.M.
In: Gene Therapy of Cancer : Methods and Protocols ; 35. Methods in Molecular Medicine ; 35 . Humana Press, Totowa, 371-392. 1 January 2000

Gene Therapy of Cancer : Methods and Protocols.
Walther, W. and Stein, U.
Methods in Molecular Medicine ; 35 . Humana Press, Totowa. 1 January 2000

Viral vectors for gene transfer. A review of their use in the treatment of human diseases.
Walther, W. and Stein, U.
Drugs 60 (2): 249-271. 1 January 2000

1999

Therapeutic genes for cancer gene therapy.
Walther, W. and Stein, U.
Molecular Biotechnology 13 (1): 21-28. November 1999

GLI gene expression in bone and soft tissue sarcomas of adult patients correlates with tumor grade.
Stein, U., Eder, C., Karsten, U., Haensch, W., Walther, W. and Schlag, P.M.
Cancer Research 59 : 1890-1895. 1 January 1999

Hyperthermia for treatment of rectal cancer: evaluation for induction of multidrug resistance gene (mdr1) expression.
Stein, U., Rau, B., Wust, P., Walther, W. and Schlag, P.M.
International Journal of Cancer 80 : 5-12. 1 January 1999

1998

Verwendung von Cytokinen und cytotoxischen Substanzen in einem neuen Verfahren zur Tumorbehandlung [Use of cytokines and cytotoxic substances in a new method to treat tumors].
Stein, U., Walther, W. and Schlag, P.M.
EP0832653 ; EP0935468 ; WO9811911. 1 April 1998

Cytokine-mediated reversal multidrug resistance.
Stein, U. and Walther, W.
Cytotechnology 27 : 271-282. 1 January 1998

IL-2 gene transfer for chemosensitization of multidrug-resistant human colon carcinoma cells.
Stein, U., Walther, W., Shoemaker, R.H. and Schlag, P.M.
1 January 1998

In vivo evaluation of a cytostatic drug-inducible vector for the expression of TNF-alpha.
Walther, W., Stein, U., Fichtner, I., Shoemaker, R.H., Alexander, M. and Schlag, P.M.
Proceedings of the American Association of Cancer Research 39 : 520. 1 January 1998

In vivo evaluation of a drug-inducible vector system for the combined gene- and chemotherapy of cancer.
Walther, W., Stein, U., Fichtner, I., Naundorf, H., Alexander, M., Shoemaker, R.H. and Schlag, P.M.
Advances in Experimental Medicine and Biology 451 : 139-144. 1 January 1998

Large and small scale RNA preparations from eukaryotic cells.
Uckert, W., Walther, W. and Stein, U.
In: RNA Isolation and Characterization Protocols. Methods in Molecular Biology ; 86 . Humana Press, Totowa,NJ, 7-14. 1 January 1998

Reversal of multidrug resistance by cytokines - evaluation of an alternative therapeutic approach in human tumors.
Stein, U., Walther, W., Rau, B., Kettelhack, C. and Schlag, P.M.
Proceedings of the American Association of Cancer Research 39 : 509. 1 January 1998

1997

Development and characterisation of novel human multidrug resistant mammary carcinoma lines in vitro and in vivo.
Stein, U., Walther, W., Lemm, M., Naundorf, H. and Fichtner, I.
International Journal of Cancer 72 : 885-891. 1 January 1997

Development and characterization of novel multidrug resistant breast cancer lines.
Walther, W., Stein, U., Lemm, M., Naundorf, H. and Fichtner, I.
Proceedings of the American Association of Cancer Research 38 : 484. 1 January 1997

Diverse effects of tumor necrosis factor a on expression of the multidrug resistance-associated genes LRP and MRP.
Stein, U., Walther, W., Laurencot, C.M., Scheffer, G.L., Scheper, R.J. and Shoemaker, R.H.
Proceedings of the American Association of Cancer Research 38 : 480. 1 January 1997

Employment of the mdr1 promoter for the chemotherapy-inducible expression of therapeutic genes in cancer gene therapy.
Walther, W., Wendt, J. and Stein, U.
Gene Therapy 4 : 544-552. 1 January 1997

In situ RT-PCR using fluorescence-labeled primers.
Stein, U., Walther, W., Wendt, J. and Schild, T.A.
Biotechniques 23 : 194-198. 1 January 1997

Modulation of MDR1 expression by cytokines in human colon carcinoma cells: an approach for reversal of multidrug.
Stein, U., Walther, W. and Shoemaker, R.H.
Biotherapy in Cancer 1 : 53-53. 1 January 1997

Tumor necrosis factor-alpha and expression of the multidrug resistance-associated genes LRP and MRP.
Stein, U., Walther, W., Laurencot, C.M., Scheffer, G.L., Scheper, R.J. and Shoemaker, R.H.
Journal of the National Cancer Institute 89 : 807-813. 1 January 1997

1996

Cell type specific and inducible promoters for vectors in gene therapy as an approach for cell targeting.
Walther, W. and Stein, U.
Journal of Molecular Medicine 74 : 379-392. 1 January 1996

Drug-inducible vector for the conditional expression of the human TNFalpha gene.
Walther, W., Stein, U., Wendt, J. and Shoemaker, R.H.
Proceedings of the American Association of Cancer Research 37 : 350. 1 January 1996

Modulation of mdr1 expression by cytokines in human colon carcinoma cells: an approach for reversal of multidrug resistance.
Stein, U., Walther, W. and Shoemaker, H.
British Journal of Cancer 74 : 1384-1391. 1 January 1996

Reversal of multidrug resistance by transduction of cytokine genes into human colon carcinoma cells.
Stein, U., Walther, W. and Shoemaker, R.H.
Journal of the National Cancer Institute 88 : 1383-1392. 1 January 1996

Targeted vectors for gene therapy of cancer and retroviral infections.
Walther, W. and Stein, U.
Molecular Biotechnology 6 : 267-286. 1 January 1996

Vincristine induction of mutant and wild-type human multidrug-resitance promoters is cell- type-specific and dose-dependent.
Stein, U., Walther, W. and Shoemaker, R.H.
Journal of Cancer Research and Clinical Oncology 122 : 275-282. 1 January 1996

1995

Gene transfer of human TNFalpha into glioblastoma cells permits modulation of mdr1 expression and potentiation of chemosensitivity.
Walther, W., Stein, U. and Pfeil, D.
International Journal of Cancer 61 (6): 832-839. 1 January 1995

Influence of retrovirally transduced human tumor-necrosis-factor-alpha on the expression of C-myc, k-ras, C-jun, p53, tgf-alpha, and cea in human colon-carcinoma cell-lines.
Uckert, W., Walther, W. and Hummel, O.
International Journal of Oncology 6 : 1027-1031. 1 January 1995

Liposome mediated transfer of marker and cytokine genes into rat and human glioblastoma cells in vitro and in vivo.
Reszka, R., Zhu, J., Weber, F., Walther, W., Greferath, R. and Dyballa, S.
Journal of Liposome Research 5 : 149-167. 1 January 1995

1994

Vektor zur Expression von therapeutisch relevanten Genen [Vector for the expression of therapy-relevant genes].
Stein, U. and Walther, W.
DE4238778A1 ; DE4238778C2 ; EP0670904 ; US 5,968,735. 19 May 1994

Conditional expression of human TNF-alpha: a system for inducible cytotoxicity.
Sparmann, G., Walther, W., Guenzburg, W.H., Uckert, W. and Salmons, B.
International Journal of Cancer 59 : 103-107. 1 January 1994

Detektion des P-Glycoproteins mit dem Antikoerper Anti-P-Glycoprotein 170-180 (Klon JSB-1): Modulation der Multidrug Resistenz in Zytokin-Gen-transfizierten Glioblastomzellen.
Stein, U. and Walther, W.
Boehringer Mannheim Biochemica Information 92 : 22-23. 1 January 1994

Influence of cytokines on mdr1 expression in human colon carcinoma cell lines: increased cytotoxicity of MDR relevant drugs.
Walther, W. and Stein, U.
Journal of Cancer Research and Clinical Oncology 120 : 471-478. 1 January 1994

RNA analysis using miniprep RNA in reverse transcriptase PCR.
Walther, W., Stein, U. and Eder, C.
Biotechniques 17 : 674-675. 1 January 1994

Retrovirus-mediated gene transfer in cancer therapy.
Uckert, W. and Walther, W.
Pharmacology & Therapeutics 63 : 323-347. 1 January 1994

Point mutations in the mdr1 promoter of human osteosarcomas are associated with in vitro responsiveness to multidrug resistance relevated drugs.
Stein, U., Walther, W. and Wunderlich, V.
European Journal of Cancer 30A (10): 1541-1545. 1994

1993

Rapid method of total RNA mini-preparation from eucaryotic cells.
Walther, W., Stein, U. and Uckert, W.
Nucleic Acids Research 21 (7): 1682. 11 April 1993

Retrovirus-mediated gene transfer of tumor necrosis factor alpha into colon carcinoma cells generates a growth inhibition.
Walther, W., Fichtner, I. and Uckert, W.
Anticancer Research 13 : 1565-1574. 1 January 1993

1992

Retroviral transduction of the human TNF alpha gene into tumour cells generates a growth inhibitory effect.
Walther, W., Huth, J., Sparmann, G. and Uckert, W.
In: European Biotechnology Today. INTERCEPT Ltd., Andover, 209-216. 1 January 1992