Browse by Research Team

Cellular and Molecular Life Sciences

From endoderm to pancreas: a multistep journey.
Spagnoli, F.M.
Cellular and Molecular Life Sciences 64 (18): 2378-2390. September 2007

Current Opinion in Genetics & Development

Guiding embryonic stem cells towards differentiation: lessons from molecular embryology.
Spagnoli, F.M. and Hemmati-Brivanlou, A.
Current Opinion in Genetics & Development 16 (5): 469-475. October 2006

Current Topics in Developmental Biology

Pancreas organogenesis: the interplay between surrounding microenvironment(s) and epithelium-intrinsic factors.
Cozzitorto, C. and Spagnoli, F.M.
Current Topics in Developmental Biology 132 : 221-256. 2019

Development

The histone methyltransferase Setd7 promotes pancreatic progenitor identity.
Kofent, J., Zhang, J. and Spagnoli, F.M.
Development 143 (19): 3573-3581. 1 October 2016

Rho signalling restriction by the RhoGAP Stard13 integrates growth and morphogenesis in the pancreas.
Petzold, K.M., Naumann, H. and Spagnoli, F.M.
Development 140 (1): 126-135. 1 January 2013

The Gata5 target, TGIF2, defines the pancreatic region by modulating BMP signals within the endoderm.
Spagnoli, F.M. and Brivanlou, A.H.
Development 135 (3): 451-461. February 2008

Developmental Biology

The RNA-binding protein, Vg1RBP, is required for pancreatic fate specification.
Spagnoli, F.M. and Brivanlou, A.H.
Developmental Biology 292 (2): 442-456. 15 April 2006

Developmental Cell

A specialized niche in the pancreatic microenvironment promotes endocrine differentiation.
Cozzitorto, C., Mueller, L., Ruzittu, S., Mah, N., Willnow, D., Darrigrand, J.F., Wilson, H., Khosravinia, D., Mahmoud, A.A., Risolino, M., Selleri, L. and Spagnoli, F.M.
Developmental Cell 55 (2): 150-162. 26 October 2020

The miR-430/427/302 family controls mesendodermal fate specification via species-specific target selection.
Rosa, A., Spagnoli, F.M. and Brivanlou, A.H.
Developmental Cell 16 (4): 517-527. 21 April 2009

Developmental Dynamics

Glimpse into Hox and tale regulation of cell differentiation and reprogramming.
Cerdá-Esteban, N. and Spagnoli, F.M.
Developmental Dynamics 243 (1): 76-87. January 2014

Diabetes

Recessive mutations in PCBD1 cause a new type of early-onset diabetes.
Simaite, D., Kofent, J., Gong, M., Rüschendorf, F., Jia, S., Arn, P., Bentler, K., Ellaway, C., Kühnen, P., Hoffmann, G.F., Blau, N., Spagnoli, F.M., Hübner, N. and Raile, K.
Diabetes 63 (10): 3557-3564. October 2014

EMBO Journal

Simply the right time to turn on insulin.
Spagnoli, F.M.
EMBO Journal 34 (13): 1740-1742. 2 July 2015

Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes.
Amicone, L., Spagnoli, F.M., Spaeth, G., Giordano, S., Tommasini, C., Bernardini, S., De Luca, V., Della Rocca, C., Weiss, M.C., Comoglio, P.M. and Tripodi, M.
EMBO Journal 16 (3): 495-503. 3 February 1997

EMBO Reports

Where do you come from; where do you go? Pluripotency, differentiation and malfunction of stem cells.
Spagnoli, F.M., Besser, D. and Benitah, S.A.
EMBO Reports 13 (1): 9-11. January 2012

Gene

Temporal and tissue-specific expression of the MET ORF driven by the complete transcriptional unit of human A1AT gene in transgenic mice.
Amicone, L., Galimi, M.A., Spagnoli, F.M., Tommasini, C., De Luca, V. and Tripodi, M.
Gene 162 (2): 323-328. 11 September 1995

Genes & Development

Mutually exclusive signaling signatures define the hepatic and pancreatic progenitor cell lineage divergence.
Rodríguez-Seguel, E., Mah, N., Naumann, H., Pongrac, I.M., Cerdá-Esteban, N., Fontaine, J.F., Wang, Y., Chen, W., Andrade-Navarro, M.A. and Spagnoli, F.M.
Genes & Development 27 (17): 1932-1946. 1 September 2013

Genome Biology

A full menu for stem-cell research.
Spagnoli, F.M. and Brivanlou, A.H.
Genome Biology 6 (3): 311. 2005

Hormone Research in Paediatrics

Two novel GATA6 mutations cause childhood-onset diabetes mellitus, pancreas malformation and congenital heart disease.
Gong, M., Simaite, D., Kühnen, P., Heldmann, M., Spagnoli, F., Blankenstein, O., Hübner, N., Hussain, K. and Raile, K.
Hormone Research in Paediatrics 79 (4): 250-256. May 2013

Journal of Cell Biology

Identification of a bipotential precursor cell in hepatic cell lines derived from transgenic mice expressing cyto-Met in the liver.
Spagnoli, F.M., Amicone, L., Tripodi, M. and Weiss, M.C.
Journal of Cell Biology 143 (4): 1101-1112. 16 November 1998

Journal of Cell Science

Inhibition of MMH (Met murine hepatocyte) cell differentiation by TGF(beta) is abrogated by pre-treatment with the heritable differentiation effector FGF1.
Spagnoli, F.M., Cicchini, C., Tripodi, M. and Weiss, M.C.
Journal of Cell Science 113 (Pt 20): 3639-3647. October 2000

Journal of Cellular Physiology

Snail controls differentiation of hepatocytes by repressing HNF4alpha expression.
Cicchini, C., Filippini, D., Coen, S., Marchetti, A., Cavallari, C., Laudadio, I., Spagnoli, F.M., Alonzi, T. and Tripodi, M.
Journal of Cellular Physiology 209 (1): 230-238. October 2006

Journal of Visualized Experiments

A system for ex vivo culturing of embryonic pancreas.
Petzold, K.M. and Spagnoli, F.M.
Journal of Visualized Experiments (66): e3979. 27 August 2012

Molecular Cell

Balancing BMP signaling through integrated inputs into the Smad1 linker.
Sapkota, G., Alarcon, C., Spagnoli, F.M., Brivanlou, A.H. and Massague, J.
Molecular Cell 25 (3): 441-454. 9 February 2007

Molecular Metabolism

The RhoGAP Stard13 controls insulin secretion through F-actin remodeling.
Naumann, H., Rathjen, T., Poy, M.N. and Spagnoli, F.M.
Molecular Metabolism 8 : 96-105. February 2018

Nature

Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche.
Willnow, D., Benary, U., Margineanu, A., Vignola, M.L., Konrath, F., Pongrac, I.M., Karimaddini, Z., Vigilante, A., Wolf, J. and Spagnoli, F.M.
Nature 597 (7874): 87-91. 2 September 2021

Nature Cell Biology

In vivo reprogramming for tissue repair.
Heinrichs, C., Spagnoli, F.M. and Berninger, B.
Nature Cell Biology 17 (3): 204-211. 27 February 2015

Nature Communications

Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors.
Escot, S., Willnow, D., Naumann, H., Di Francescantonio, S. and Spagnoli, F.M.
Nature Communications 9 (1): 5082. 30 November 2018

Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2.
Cerdá-Esteban, N., Naumann, H., Ruzittu, S., Mah, N., Pongrac, I.M., Cozzitorto, C., Hommel, A., Andrade-Navarro, M.A., Bonifacio, E. and Spagnoli, F.M.
Nature Communications 8 : 14127. 13 February 2017

Seminars in Cell & Developmental Biology

Xenopus as a model system for studying pancreatic development and diabetes.
Kofent, J. and Spagnoli, F.M.
Seminars in Cell & Developmental Biology 51 : 106-116. March 2016

Small GTPases

RhoGAP control of pancreas development: putting cells in the right place at the right time.
Zygmunt, T. and Spagnoli, F.M.
Small GTPases 4 (2): 127-131. April 2013