Browse by Research Team

2021

Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche.
Willnow, D., Benary, U., Margineanu, A., Vignola, M.L., Konrath, F., Pongrac, I.M., Karimaddini, Z., Vigilante, A., Wolf, J. and Spagnoli, F.M.
Nature 597 (7874): 87-91. 2 September 2021

2020

A specialized niche in the pancreatic microenvironment promotes endocrine differentiation.
Cozzitorto, C., Mueller, L., Ruzittu, S., Mah, N., Willnow, D., Darrigrand, J.F., Wilson, H., Khosravinia, D., Mahmoud, A.A., Risolino, M., Selleri, L. and Spagnoli, F.M.
Developmental Cell 55 (2): 150-162. 26 October 2020

2019

Pancreas organogenesis: the interplay between surrounding microenvironment(s) and epithelium-intrinsic factors.
Cozzitorto, C. and Spagnoli, F.M.
Current Topics in Developmental Biology 132 : 221-256. 2019

2018

Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors.
Escot, S., Willnow, D., Naumann, H., Di Francescantonio, S. and Spagnoli, F.M.
Nature Communications 9 (1): 5082. 30 November 2018

The RhoGAP Stard13 controls insulin secretion through F-actin remodeling.
Naumann, H., Rathjen, T., Poy, M.N. and Spagnoli, F.M.
Molecular Metabolism 8 : 96-105. February 2018

2017

Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2.
Cerdá-Esteban, N., Naumann, H., Ruzittu, S., Mah, N., Pongrac, I.M., Cozzitorto, C., Hommel, A., Andrade-Navarro, M.A., Bonifacio, E. and Spagnoli, F.M.
Nature Communications 8 : 14127. 13 February 2017

2016

The histone methyltransferase Setd7 promotes pancreatic progenitor identity.
Kofent, J., Zhang, J. and Spagnoli, F.M.
Development 143 (19): 3573-3581. 1 October 2016

Xenopus as a model system for studying pancreatic development and diabetes.
Kofent, J. and Spagnoli, F.M.
Seminars in Cell & Developmental Biology 51 : 106-116. March 2016

2015

Simply the right time to turn on insulin.
Spagnoli, F.M.
EMBO Journal 34 (13): 1740-1742. 2 July 2015

In vivo reprogramming for tissue repair.
Heinrichs, C., Spagnoli, F.M. and Berninger, B.
Nature Cell Biology 17 (3): 204-211. 27 February 2015

2014

Recessive mutations in PCBD1 cause a new type of early-onset diabetes.
Simaite, D., Kofent, J., Gong, M., Rüschendorf, F., Jia, S., Arn, P., Bentler, K., Ellaway, C., Kühnen, P., Hoffmann, G.F., Blau, N., Spagnoli, F.M., Hübner, N. and Raile, K.
Diabetes 63 (10): 3557-3564. October 2014

Glimpse into Hox and tale regulation of cell differentiation and reprogramming.
Cerdá-Esteban, N. and Spagnoli, F.M.
Developmental Dynamics 243 (1): 76-87. January 2014

2013

Mutually exclusive signaling signatures define the hepatic and pancreatic progenitor cell lineage divergence.
Rodríguez-Seguel, E., Mah, N., Naumann, H., Pongrac, I.M., Cerdá-Esteban, N., Fontaine, J.F., Wang, Y., Chen, W., Andrade-Navarro, M.A. and Spagnoli, F.M.
Genes & Development 27 (17): 1932-1946. 1 September 2013

Two novel GATA6 mutations cause childhood-onset diabetes mellitus, pancreas malformation and congenital heart disease.
Gong, M., Simaite, D., Kühnen, P., Heldmann, M., Spagnoli, F., Blankenstein, O., Hübner, N., Hussain, K. and Raile, K.
Hormone Research in Paediatrics 79 (4): 250-256. May 2013

RhoGAP control of pancreas development: putting cells in the right place at the right time.
Zygmunt, T. and Spagnoli, F.M.
Small GTPases 4 (2): 127-131. April 2013

Rho signalling restriction by the RhoGAP Stard13 integrates growth and morphogenesis in the pancreas.
Petzold, K.M., Naumann, H. and Spagnoli, F.M.
Development 140 (1): 126-135. 1 January 2013

2012

A system for ex vivo culturing of embryonic pancreas.
Petzold, K.M. and Spagnoli, F.M.
Journal of Visualized Experiments (66): e3979. 27 August 2012

Where do you come from; where do you go? Pluripotency, differentiation and malfunction of stem cells.
Spagnoli, F.M., Besser, D. and Benitah, S.A.
EMBO Reports 13 (1): 9-11. January 2012

2009

The miR-430/427/302 family controls mesendodermal fate specification via species-specific target selection.
Rosa, A., Spagnoli, F.M. and Brivanlou, A.H.
Developmental Cell 16 (4): 517-527. 21 April 2009

2008

The Gata5 target, TGIF2, defines the pancreatic region by modulating BMP signals within the endoderm.
Spagnoli, F.M. and Brivanlou, A.H.
Development 135 (3): 451-461. February 2008

2007

From endoderm to pancreas: a multistep journey.
Spagnoli, F.M.
Cellular and Molecular Life Sciences 64 (18): 2378-2390. September 2007

Balancing BMP signaling through integrated inputs into the Smad1 linker.
Sapkota, G., Alarcon, C., Spagnoli, F.M., Brivanlou, A.H. and Massague, J.
Molecular Cell 25 (3): 441-454. 9 February 2007

2006

Guiding embryonic stem cells towards differentiation: lessons from molecular embryology.
Spagnoli, F.M. and Hemmati-Brivanlou, A.
Current Opinion in Genetics & Development 16 (5): 469-475. October 2006

Snail controls differentiation of hepatocytes by repressing HNF4alpha expression.
Cicchini, C., Filippini, D., Coen, S., Marchetti, A., Cavallari, C., Laudadio, I., Spagnoli, F.M., Alonzi, T. and Tripodi, M.
Journal of Cellular Physiology 209 (1): 230-238. October 2006

The RNA-binding protein, Vg1RBP, is required for pancreatic fate specification.
Spagnoli, F.M. and Brivanlou, A.H.
Developmental Biology 292 (2): 442-456. 15 April 2006

2005

A full menu for stem-cell research.
Spagnoli, F.M. and Brivanlou, A.H.
Genome Biology 6 (3): 311. 2005

2000

Inhibition of MMH (Met murine hepatocyte) cell differentiation by TGF(beta) is abrogated by pre-treatment with the heritable differentiation effector FGF1.
Spagnoli, F.M., Cicchini, C., Tripodi, M. and Weiss, M.C.
Journal of Cell Science 113 (Pt 20): 3639-3647. October 2000

1998

Identification of a bipotential precursor cell in hepatic cell lines derived from transgenic mice expressing cyto-Met in the liver.
Spagnoli, F.M., Amicone, L., Tripodi, M. and Weiss, M.C.
Journal of Cell Biology 143 (4): 1101-1112. 16 November 1998

1997

Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes.
Amicone, L., Spagnoli, F.M., Spaeth, G., Giordano, S., Tommasini, C., Bernardini, S., De Luca, V., Della Rocca, C., Weiss, M.C., Comoglio, P.M. and Tripodi, M.
EMBO Journal 16 (3): 495-503. 3 February 1997

1995

Temporal and tissue-specific expression of the MET ORF driven by the complete transcriptional unit of human A1AT gene in transgenic mice.
Amicone, L., Galimi, M.A., Spagnoli, F.M., Tommasini, C., De Luca, V. and Tripodi, M.
Gene 162 (2): 323-328. 11 September 1995