Browse by Research Team

2024

The evolving landscape of cardiometabolic diseases.
Eroglu, T., Capone, F. and Schiattarella, G.G.
EBioMedicine 109 : 105447. November 2024

Multilayer nanocarrier for the codelivery of interferons: a promising strategy for biocompatible and long-acting antiviral treatment.
Ramos, T.I., Villacis-Aguirre, C.A., Sandoval, F.S., Martin-Solano, S., Manrique-Suárez, V., Rodríguez, H., Santiago-Padilla, L., Debut, A., Gómez-Gaete, C., Arias, M.T., Montesino, R., Lamazares, E., Cabezas, I., Hugues, F., Parra, N.C., Altamirano, C., Ramos, O.S., Santiago-Vispo, N. and Toledo, J.R.
Pharmaceutics 16 (11): 1349. 22 October 2024

Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications.
Bode, D., Pronto, J.R.D., Schiattarella, G.G. and Voigt, N.
Nature Reviews Cardiology 21 (10): 682-700. October 2024

Systems biology approach uncovers candidates for liver-heart interorgan crosstalk in HFpEF.
Strocchi, S., Liu, L., Wang, R., Häseli, S.P., Capone, F., Bode, D., Nambiar, N., Eroglu, T., Santiago Padilla, L., Farrelly, C., Vacca, A., Mascagni, M., Oeing, C.U., Kintscher, U., Jung, S., Diezel, S.A., Liévano Contreras, S.V., Zhou, M., Seldin, M. and Schiattarella, G.G.
Circulation Research 135 (8): 873-876. 27 September 2024

Lifestyle interventions in cardiometabolic HFpEF: dietary and exercise modalities.
Vacca, A., Wang, R., Nambiar, N., Capone, F., Farrelly, C., Mostafa, A., Sechi, L.A. and Schiattarella, G.G.
Heart Failure Reviews 16 September 2024 (In Press)

Lysozyme 1 inflamed CCR2(+) macrophages promote obesity-induced cardiac dysfunction.
Zhang, L., Han, H., Xu, A., Sathe, A., Fu, S., Zhao, J., Cai, W., Yang, Y., Liu, J., Bai, H., Ben, J., Zhu, X., Li, X., Yang, Q., Wang, Z., Gu, Y., Xing, C., Schiattarella, G.G., Cheng, S.Y., Zhang, H. and Chen, Q.
Circulation Research 135 (5): 596-613. 16 August 2024

Targeting HFpEF: unlocking the potential of glucagon receptor blockade.
Santiago Padilla, L. and Schiattarella, G.G.
Circulation Research 135 (5): 629-631. 16 August 2024

Mitophagy modulation for the treatment of cardiovascular diseases.
Forte, M., D'Ambrosio, L., Schiattarella, G.G., Salerno, N., Perrone, M.A., Loffredo, F.S., Bertero, E., Pilichou, K., Manno, G., Valenti, V., Spadafora, L., Bernardi, M., Simeone, B., Sarto, G., Frati, G., Perrino, C. and Sciarretta, S.
European Journal of Clinical Investigation 54 (8): e14199. August 2024

Polycystin-1 loss of function increases susceptibility to atrial fibrillation through impaired DNA damage response.
Hendrickson, T., Giese, A., Fiedler, M., Perez, W., Reyes-Sanchez, E., Reyes-Lozano, M., Wang, S., Venegas-Zamora, L., Provasek, V., El-Essawi, A., Breitenbach, I., Fakuade, F.E., Kutschka, I., Schiattarella, G.G., Voigt, N., Valderrabano, M. and Altamirano, F.
bioRxiv : 2024.07.08.602618. 12 July 2024

Tackling metabolic defects in HFpEF.
Wang, R. and Schiattarella, G.G.
European Heart Journal 45 (17): 1494-1496. 1 May 2024

Beyond weight loss: the emerging role of incretin-based treatments in cardiometabolic HFpEF.
Capone, F., Nambiar, N. and Schiattarella, G.G.
Current Opinion in Cardiology 39 (2): 148-153. May 2024

A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on pulmonary circulation & right ventricular function.
Ameri, P., Mercurio, V., Pollesello, P., Anker, M.S., Backs, Jo., Bayes-Genis, A., Borlaug, B.A., Burkhoff, D., Caravita, S., Chan, S.Y., de Man, F., Giannakoulas, G., González, A., Guazzi, M., Hassoun, P.M., Hemnes, A.R., Maack, C., Madden, B., Melenovsky, V., Müller, O.J., Papp, Z., Pullamsetti, S.S., Rainer, P.P., Redfield, M.M., Rich, S., Schiattarella, G.G., Skaara, H., Stellos, K., Tedford, R.J., Thum, T., Vachiery, J.L., van der Meer, P., Van Linthout, S., Pruszczyk, P., Seferovic, P., Coats, A.J.S., Metra, M., Rosano, G., Rosenkranz, S. and Tocchetti, C.G.
European Journal of Heart Failure 26 (4): 707-729. April 2024

Impairment of the adrenergic reserve associated with exercise intolerance in a murine model of heart failure with preserved ejection fraction.
Semmler, L., Jeising, T., Huettemeister, J., Bathe-Peters, M., Georgoula, K., Roshanbin, R., Sander, P., Fu, S., Bode, D., Hohendanner, F., Pieske, B., Annibale, P., Schiattarella, G.G., Oeing, C.U. and Heinzel, F.R.
Acta Physiologica 240 (4): e14124. April 2024

From gut to heart: role of indole-3-propionic acid in HFpEF.
Vacca, A. and Schiattarella, G.G.
Circulation Research 134 (4): 390-392. 16 February 2024

2023

Impaired T cell IRE1α-XBP1 signaling directs inflammation in experimental Heart Failure with Preserved Ejection Fraction.
Smolgovsky, S., Bayer, A.L., Kaur, K., Sanders, E., Aronovitz, M., Filipp, M.E., Thorp, E.B., Schiattarella, G.G., Hill, J.A., Blanton, R.M., Cubillos-Ruiz, J.R. and Alcaide, P.
Journal of Clinical Investigation 133 (24): e171874. 15 December 2023

Genetics-diet crossroads: Unveiling new insights into hypertrophic cardiomyopathy.
Häseli, S.P. and Schiattarella, G.
Journal of Molecular and Cellular Cardiology Plus 6 : 100051. December 2023

Comments on the myPACE randomized clinical trial.
Rodolico, D. and Schiattarella, G.G.
JAMA Cardiology 8 (8): 794-795. August 2023

Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease.
Ziegler, K.A., Ahles, A., Dueck, A., Esfandyari, D., Pichler, P., Weber, K., Kotschi, S., Bartelt, A., Sinicina, I., Graw, M., Leonhardt, H., Weckbach, L.T., Massberg, S., Schifferer, M., Simons, M., Hoeher, L., Luo, J., Ertürk, A., Schiattarella, G.G., Sassi, Y., Misgeld, T. and Engelhardt, S.
Science 381 (6655): 285-290. 21 July 2023

The lure of cardiac metabolism in the diagnosis, prevention, and treatment of heart failure.
Rodolico, D., Schiattarella, G.G. and Taegtmeyer, H.
JACC: Heart Failure 11 (6): 637-645. June 2023

Molecular mechanisms underlying the beneficial effects of exercise and dietary interventions in the prevention of cardiometabolic diseases.
Forte, M., Rodolico, D., Ameri, P., Catalucci, D., Chimenti, C., Crotti, L., Schirone, L., Pingitore, A., Torella, D., Iacovone, G., Valenti, V., Schiattarella, G.G., Perrino, C. and Sciarretta, S.
Journal of Cardiovascular Medicine 24 (Suppl 1): e3-e14. 1 April 2023

Cardiometabolic HFpEF: NASH of the heart.
Capone, F., Vettor, Roberto and Schiattarella, G.G.
Circulation 147 (6): 451-453. 7 February 2023

Long COVID and the cardiovascular system - elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial & Pericardial Diseases.
Gyöngyösi, M., Alcaide, P., Asselbergs, F.W., Brundel, B.J.J.M., Camici, G.G., da Costa Martins, P., Ferdinandy, P., Fontana, M., Girao, H., Gnecchi, M., Gollmann-Tepeköylü, C., Kleinbongard, P., Krieg, T., Madonna, R., Paillard, M., Pantazis, A., Perrino, C., Pesce, M., Schiattarella, G.G., Sluijter, J.P.G., Steffens, S., Tschöpe, C., Van Linthout, S. and Davidson, S.M.
Cardiovascular Research 119 (2): 336-356. February 2023

2022

High-resolution transthoracic echocardiography accurately detects pulmonary arterial pressure and decreased right ventricular contractility in a mouse model of pulmonary fibrosis and secondary pulmonary hypertension.
Hansen, T.S., Bubb, K.J., Schiattarella, G.G., Ugander, M., Tan, T.C. and Figtree, G.A.
Journal of the American Heart Association 11 (23): e018353. 6 December 2022

Cardiac metabolism in HFpEF: from fuel to signalling.
Capone, F., Sotomayor-Flores, C., Bode, D., Wang, R., Rodolico, D., Strocchi, S. and Schiattarella, G.G.
Cardiovascular Research 118 (18): 3556-3575. December 2022

Mitochondrial a kinase anchor proteins in cardiovascular health and disease: a review article on behalf of the Working Group on Cellular and Molecular Biology of the Heart of the Italian Society of Cardiology.
Paolillo, R., D’Apice, S., Schiattarella, G.G., Ameri, P., Borzacchiello, D., Catalucci, D., Chimenti, C., Crotti, L., Sciarretta, S., Torella, D., Feliciello, A. and Perrino, C.
International Journal of Molecular Sciences 23 (14): 7691. 12 July 2022

Impaired AMP-activated protein kinase signaling in heart failure with preserved ejection fraction-associated atrial fibrillation.
Tong, D., Schiattarella, G.G., Jiang, N., Daou, D., Luo, Y., Link, M.S., Lavandero, S., Gillette, T.G. and Hill, J.A.
Circulation 146 (1): 73-76. 5 July 2022

Up next: the dawn of systems biology in HFpEF research.
Bode, D., Sotomayor-Flores, C. and Schiattarella, G.G.
Journal of Molecular and Cellular Cardiology 168 : 96-97. July 2022

Immunometabolic mechanisms of heart failure with preserved ejection fraction.
Schiattarella, G.G., Alcaide, P., Condorelli, G., Gillette, T.G., Heymans, S., Jones, E.A.V., Kallikourdis, M., Lichtman, A., Marelli-Berg, F., Shah, S.J., Thorp, E.B. and Hill, J.A.
Nature Cardiovascular Research 1 (3): 211-222. March 2022

2021

Canagliflozin and myocardial oxidative stress: SGLT1 inhibition takes centre stage.
Schiattarella, G.G. and Bode, D.
European Heart Journal 42 (48): 4961-4963. 21 December 2021

Heart failure with preserved ejection fraction in humans and mice: embracing clinical complexity in mouse models.
Withaar, C., Lam, C.S.P., Schiattarella, G.G., de Boer, R.A. and Meems, L.M.G.
European Heart Journal 42 (43): 4420-4430. 14 November 2021

Cardiometabolic HFpEF: mechanisms and therapies.
Schiattarella, G.G. and Hill, J.A.
CardioMetabolic Syndrome Journal 1 (2): 117-124. September 2021

Metabolism and inflammation in cardiovascular health and diseases: mechanisms to therapies.
Schiattarella, G.G., Wang, Y., Tian, R. and Hill, J.A.
Journal of Molecular and Cellular Cardiology 157 : 113-114. August 2021

Activation of autophagic flux blunts cardiac ischemia/reperfusion injury.
Xie, M., Cho, G.W., Kong, Y., Li, D.L., Altamirano, F., Luo, X., Morales, C.R., Jiang, N., Schiattarella, G.G., May, H.I., Medina, J., Shelton, J.M., Ferdous, A., Gillette, T.G. and Hill, J.A.
Circulation Research 129 (3): 435-450. 23 July 2021

Cooperative binding of ETS2 and NFAT link Erk1/2 and calcineurin signaling in the pathogenesis of cardiac hypertrophy.
Luo, Y., Jiang, N., May, H.I., Luo, X., Ferdous, A., Schiattarella, G.G., Chen, G., Li, Q., Li, C., Rothermel, B.A., Jiang, D., Lavandero, S., Gillette, T.G. and Hill, J.A.
Circulation 144 (1): 34-51. 6 July 2021

Implications of SGLT inhibition on redox signalling in atrial fibrillation.
Bode, D., Semmler, L., Oeing, C.U., Alogna, A., Schiattarella, G.G., Pieske, B.M., Heinzel, F.R. and Hohendanner, F.
International Journal of Molecular Sciences 22 (11): 5937. 31 May 2021

NAD(+) repletion reverses heart failure with preserved ejection fraction.
Tong, D., Schiattarella, G.G., Jiang, N., Altamirano, F., Szweda, P.A., Elnwasany, A., Lee, D.I., Yoo, H., Kass, D.A., Szweda, L.I., Lavandero, S., Verdin, E., Gillette, T.G. and Hill, J.A.
Circulation Research 128 (11): 1629-1641. 28 May 2021

The role of mitochondrial dynamics in cardiovascular diseases.
Forte, M., Schirone, L., Ameri, P., Basso, C., Catalucci, D., Modica, J., Chimenti, C., Crotti, L., Frati, G., Rubattu, S., Schiattarella, G.G., Torella, D., Perrino, C., Indolfi, C. and Sciarretta, S.
British Journal of Pharmacology 178 (10): 2060-2076. May 2021

Transverse aortic constriction induces gut barrier alterations, microbiota remodeling and systemic inflammation.
Boccella, N., Paolillo, R., Coretti, L., D'Apice, S., Lama, A., Giugliano, G., Schiattarella, G.G., Cuomo, M., d'Aquino, I., Cavaliere, G., Paciello, O., Mollica, M.P., Mattace Raso, G., Esposito, G., Lembo, F. and Perrino, C.
Scientific Reports 11 (1): 7404. 1 April 2021

Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction.
Schiattarella, G.G., Altamirano, F., Kim, S.Y., Tong, D., Ferdous, A., Piristine, H., Dasgupta, S., Wang, X., French, K.M., Villalobos, E., Spurgin, S.B., Waldman, M., Jiang, N., May, H.I., Hill, T.M., Luo, Y., Yoo, H., Zaha, V.G., Lavandero, S., Gillette, T.G. and Hill, J.A.
Nature Communications 12 (1): 1684. 16 March 2021

Metabolic inflammation in heart failure with preserved ejection fraction.
Schiattarella, G.G., Rodolico, D. and Hill, J.A.
Cardiovascular Research 117 (2): 423-434. 1 February 2021

2020

Epigenetic reader BRD4 (Bromodomain-Containing Protein 4) governs nucleus-encoded mitochondrial transcriptome to regulate cardiac function.
Kim, S.Y., Zhang, X., Schiattarella, G.G., Altamirano, F., Ramos, T.A.R., French, K.M., Jiang, N., Szweda, P.A., Evers, B.M., May, H.I., Luo, X., Li, H., Szweda, L.I., Maracaja-Coutinho, V., Lavandero, S., Gillette, T.G. and Hill, J.A.
Circulation 142 (24): 2356-2370. 15 December 2020

Distinctive patterns of inflammation across the heart failure syndrome.
Schiattarella, G.G., Sequeira, V. and Ameri, P.
Heart Failure Reviews 26 : 1333–1344. November 2020

Immunoglobulins G modulate endothelial function and affect insulin sensitivity in humans.
Napoli, R., Ruvolo, A., Triggianese, P., Prevete, N., Schiattarella, G.G., Nigro, C., Miele, C., Magliulo, F., Grassi, S., Pecoraro, A., Cittadini, A., Esposito, G., de Paulis, A. and Spadaro, G.
Nutrition Metabolism and Cardiovascular Diseases 30 (11): 2085-2092. 30 October 2020

Left ventricular dysfunction in heart failure with preserved ejection fraction-molecular mechanisms and impact on right ventricular function.
Heinzel, F.R., Hegemann, N., Hohendanner, F., Primessnig, U., Grune, J., Blaschke, F., de Boer, R.A., Pieske, B., Schiattarella, G.G. and Kuebler, W.M.
Cardiovascular Diagnosis and Therapy 10 (5): 1541-1560. October 2020

Impact of chronic kidney disease on platelet aggregation in patients with acute coronary syndrome.
Ilardi, F., Gargiulo, G., Paolillo, R., Ferrone, M., Cimino, S., Giugliano, G., Schiattarella, G.G., Verde, N., Stabile, E., Perrino, C., Cirillo, P., Coscioni, E., Morisco, C. and Esposito, G.
Journal of Cardiovascular Medicine 21 (9): 660-666. September 2020

Feeding diastolic dysfunction: is it a bug?
Esposito, G. and Schiattarella, G.G.
Journal of Cardiac Failure 26 (8): 703-704. August 2020

FoxO1-Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth.
Ferdous, A., Wang, Z.V., Luo, Y., Li, D.L., Luo, X., Schiattarella, G.G., Altamirano, F., May, H.I., Battiprolu, P.K., Nguyen, A., Rothermel, B.A., Lavandero, S., Gillette, T.G. and Hill, J.A.
Nature Communications 11 (1): 2551. 21 May 2020

Can HFpEF and HFrEF coexist?
Schiattarella, G.G., Tong, D. and Hill, J.A.
Circulation 141 (9): 709-711. 3 March 2020

Novel basic science insights to improve the management of heart failure: review of the working group on cellular and molecular biology of the heart of the italian society of cardiology.
Ameri, P., Schiattarella, G.G., Crotti, L., Torchio, M., Bertero, E., Rodolico, D., Forte, M., Di Mauro, V., Paolillo, R., Chimenti, C., Torella, D., Catalucci, D., Sciarretta, S., Basso, C., Indolfi, C. and Perrino, C.
International Journal of Molecular Sciences 21 (4): 1192. 11 February 2020

2019

Female sex is protective in a preclinical model of heart failure with preserved ejection fraction.
Tong, D., Schiattarella, G.G., Jiang, N., May, H.I., Lavandero, S., Gillette, T.G. and Hill, J.A.
Circulation 140 (21): 1769-1771. 19 November 2019

Polycystin-1 assembles with Kv channels to govern cardiomyocyte repolarization and contractility.
Altamirano, F., Schiattarella, G.G., French, K.M., Kim, S.Y., Engelberger, F., Kyrychenko, S., Villalobos, E., Tong, D., Schneider, J.W., Ramirez-Sarmiento, C.A., Lavandero, S., Gillette, T.G. and Hill, J.A.
Circulation 140 (11): 921-936. 10 September 2019

Remodeling of substrate consumption in the murine sTAC model of heart failure.
Turer, A., Altamirano, F., Schiattarella, G., May, H., Gillette, T.G., Malloy, C.R. and Merritt, M.E.
Journal of Molecular and Cellular Cardiology 134 : 144-153. September 2019

Microbial metabolites as predictive biomarkers: a paradigm shift for cardiovascular risk stratification.
Schiattarella, G.G. and Trimarco, B.
European Heart Journal 40 (32): 2710-2712. 21 August 2019

Fibroblast primary cilia are required for cardiac fibrosis.
Villalobos, E., Criollo, A., Schiattarella, G.G., Altamirano, F., French, K.M., May, H.I., Jiang, N., Nguyen, N.U.N., Romero, D., Roa, J.C., García, L., Diaz-Araya, G., Morselli, E., Ferdous, A., Conway, S.J., Sadek, H.A., Gillette, T.G., Lavandero, S. and Hill, J.A.
Circulation 139 (20): 2342-2357. 14 May 2019

Nitrosative stress drives heart failure with preserved ejection fraction.
Schiattarella, G.G., Altamirano, F., Tong, D., French, K.M., Villalobos, E., Kim, S.Y., Luo, X., Jiang, N., May, H.I., Wang, Z.V., Hill, T.M., Mammen, P.P.A., Huang, J., Lee, D.I., Hahn, V.S., Sharma, K., Kass, D.A., Lavandero, S., Gillette, T.G. and Hill, J.A.
Nature 568 (7752): 351-356. 18 April 2019

Diagnostics and therapeutic implications of gut microbiota alterations in cardiometabolic diseases.
Schiattarella, G.G., Sannino, A., Esposito, G. and Perrino, C.
Trends in Cardiovascular Medicine 29 (3): 141-147. April 2019

Inflammation in aortic stenosis: shaping the biomarkers network.
Schiattarella, G.G. and Perrino, C.
International Journal of Cardiology 274 : 279-280. 1 January 2019

2018

Extracellular signal-regulated kinase (ERK) in left ventricular pathological hypertrophy: not a new kid on the block anymore.
Schiattarella, G.G.
International Journal of Cardiology 271 : 260-261. 15 November 2018

The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy.
Makarewich, C.A., Munir, A.Z., Schiattarella, G.G., Bezprozvannaya, S., Raguimova, O.N., Cho, E.E., Vidal, A.H., Robia, S.L., Bassel-Duby, R. and Olson, E.N.
eLife 7 : e38319. 9 October 2018

Ventricular phenotyping reviews.
Schiattarella, G.G., Tong, D. and Hill, J.A.
Circulation 138 (8): 749-750. 21 August 2018

Epigenetic modulation of vascular diseases: assessing the evidence and exploring the opportunities.
Schiattarella, G.G., Madonna, R., Van Linthout, S., Thum, T., Schulz, R., Ferdinandy, P. and Perrino, C.
Vascular Pharmacology 107 : 43-52. August 2018

Perivascular fibrosis and the microvasculature of the heart. still hidden secrets of pathophysiology?
Ytrehus, K., Hulot, J.S., Perrino, Cinzia, Schiattarella, G.G. and Madonna, R.
Vascular Pharmacology 107 : 78-83. August 2018

Effects of carvedilol versus metoprolol on platelet aggregation in patients with acute coronary syndrome: the PLATE-BLOCK study.
Ilardi, F., Gargiulo, G., Schiattarella, G.G., Giugliano, G., Paolillo, R., Menafra, G., De Angelis, E., Scudiero, L., Franzone, A., Stabile, E., Perrino, C., Cirillo, P., Morisco, C., Izzo, R., Trimarco, V. and Esposito, G.
American Journal of Cardiology 122 (1): 6-11. 1 July 2018

Cytosolic DNA sensing promotes macrophage transformation and governs myocardial ischemic injury.
Cao, D.J., Schiattarella, G.G., Villalobos, E., Jiang, N., May, H.I., Li, T., Chen, Z.J., Gillette, T.G. and Hill, J.A.
Circulation 137 (24): 2613-2634. 12 June 2018

Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.
Fernández, Á.F., Sebti, S., Wei, Y., Zou, Z., Shi, M., McMillan, K.L., He, C., Ting, T., Liu, Y., Chiang, W.C., Marciano, D.K., Schiattarella, G.G., Bhagat, G., Moe, O.W., Hu, M.C. and Levine, B.
Nature 558 (7708): 136-140. 7 June 2018

Loss of Akap1 exacerbates pressure overload-induced cardiac hypertrophy and heart failure.
Schiattarella, G.G., Boccella, N., Paolillo, R., Cattaneo, F., Trimarco, V., Franzone, A., D'Apice, S., Giugliano, G., Rinaldi, L., Borzacchiello, D., Gentile, A., Lombardi, A., Feliciello, A., Esposito, G. and Perrino, C.
Frontiers in Physiology 9 : 558. 28 May 2018

Epigenetic control of lipid metabolism: implications for lifespan and healthspan.
Schiattarella, G.G. and Hill, J.A.
Cardiovascular Research 114 (6): e33-e35. 1 May 2018

Polycystin-2-dependent control of cardiomyocyte autophagy.
Criollo, A., Altamirano, F., Pedrozo, Z., Schiattarella, G.G., Li, D.L., Rivera-Mejías, P., Sotomayor-Flores, C., Parra, V., Villalobos, E., Battiprolu, P.K., Jiang, N., May, H.I., Morselli, E., Somlo, S., de Smedt, H., Gillette, T.G., Lavandero, S. and Hill, J.A.
Journal of Molecular and Cellular Cardiology 118 : 110-121. May 2018

Rac1 modulates endothelial function and platelet aggregation in diabetes mellitus.
Schiattarella, G.G., Carrizzo, A., Ilardi, F., Damato, A., Ambrosio, M., Madonna, M., Trimarco, V., Marino, M., De Angelis, E., Settembrini, S., Perrino, C., Trimarco, B., Esposito, G. and Vecchione, C.
Journal of the American Heart Association 7 (8): e007322. 17 April 2018

Comparison of baseline characteristics and outcomes in men versus women with aortic stenosis undergoing transcatheter aortic valve implantation.
Sannino, A., Szerlip, M., Harrington, K., Schiattarella, G.G. and Grayburn, P.A.
American Journal of Cardiology 121 (7): 844-849. 1 April 2018

Double layered stents for carotid angioplasty: a meta-analysis of available clinical data.
Sannino, A., Giugliano, G., Toscano, E., Schiattarella, G.G., Franzone, A., Tesorio, T., Trimarco, B., Esposito, G. and Stabile, E.
Catheterization and Cardiovascular Interventions 91 (4): 751-757. 1 March 2018

Akap1 regulates vascular function and endothelial cells behavior.
Schiattarella, G.G., Cattaneo, F., Carrizzo, A., Paolillo, R., Boccella, N., Ambrosio, M., Pironti, G., Damato, A., Franzone, A., Russo, G., Magliulo, F., Pirozzi, M., Storto, M., Madonna, M., Gargiulo, G., Trimarco, V., Rinaldi, L., De Lucia, M., Garbi, C., Feliciello, A., Esposito, G., Vecchione, C. and Perrino, C.
Hypertension 71 (3): 507-517. March 2018

EGFR activation triggers cellular hypertrophy and lysosomal disease in NAGLU-depleted cardiomyoblasts, mimicking the hallmarks of mucopolysaccharidosis IIIB.
De Pasquale, V., Pezone, A., Sarogni, P., Tramontano, A., Schiattarella, G.G., Avvedimento, V.E., Paladino, S. and Pavone, L.M.
Cell Death & Disease 9 (2): 40. 18 January 2018

2017

Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis.
Schiattarella, G.G., Sannino, A., Toscano, E., Giugliano, G., Gargiulo, G., Franzone, A., Trimarco, B., Esposito, G. and Perrino, C.
European Heart Journal 38 (39): 2948-2956. 14 October 2017

Is load-induced ventricular hypertrophy ever compensatory?
Schiattarella, G.G., Hill, T.M. and Hill, J.A.
Circulation 136 (14): 1273-1275. 3 October 2017

Survival and cardiovascular outcomes of patients with secondary mitral regurgitation: a systematic review and meta-analysis.
Sannino, A., Smith, R.L., Schiattarella, G.G., Trimarco, B., Esposito, G. and Grayburn, P.A.
JAMA Cardiology 2 (10): 1130-1139. 1 October 2017

Metabolic control and oxidative stress in pathological cardiac remodelling.
Schiattarella, G.G. and Hill, J.A.
European Heart Journal 38 (18): 1399-1401. 7 May 2017

Meta-analysis of effect of body mass index on outcomes after transcatheter aortic valve implantation.
Sannino, A., Schiattarella, G.G., Toscano, E., Gargiulo, G., Giugliano, G., Galderisi, M., Losi, M.A., Stabile, E., Cirillo, P., Imbriaco, M., Grayburn, P.A., Trimarco, B. and Esposito, G.
American Journal of Cardiology 119 (2): 308-316. 15 January 2017

Hypoxia induces heart regeneration in adult mice.
Nakada, Y., Canseco, D.C., Thet, S., Abdisalaam, S., Asaithamby, A., Santos, C.X., Shah, A.M., Zhang, Hua, Faber, J.E., Kinter, M.T., Szweda, L.I., Xing, C., Hu, Z., Deberardinis, R.J., Schiattarella, G., Hill, J.A., Oz, O., Lu, Z., Zhang, C.C., Kimura, W. and Sadek, H.A.
Nature 541 (7636): 222-227. 12 January 2017

2016

A meta-analysis of the impact of pre-existing and new-onset atrial fibrillation on clinical outcomes in patients undergoing transcatheter aortic valve implantation.
Sannino, A., Gargiulo, G., Schiattarella, G.G., Perrino, C., Stabile, E., Losi, M.A., Galderisi, M., Izzo, R., de Simone, G., Trimarco, B. and Esposito, G.
EuroIntervention 12 (8): e1047-e1056. 10 October 2016

Cardiovascular effects of histone deacetylase inhibitors epigenetic therapies: systematic review of 62 studies and new hypotheses for future research.
Schiattarella, G.G., Sannino, A., Toscano, E., Cattaneo, F., Trimarco, B., Esposito, G. and Perrino, C.
International Journal of Cardiology 219 : 396-403. 15 September 2016

Therapeutic targeting of autophagy in cardiovascular disease.
Schiattarella, G.G. and Hill, J.A.
Journal of Molecular and Cellular Cardiology 95 : 86-93. June 2016

Akap1 deficiency promotes mitochondrial aberrations and exacerbates cardiac injury following permanent coronary ligation via enhanced mitophagy and apoptosis.
Schiattarella, G.G., Cattaneo, F., Pironti, G., Magliulo, F., Carotenuto, G., Pirozzi, M., Polishchuk, R., Borzacchiello, D., Paolillo, R., Oliveti, M., Boccella, N., Avvedimento, M., Sepe, M., Lombardi, A., Busiello, R.A., Trimarco, B., Esposito, G., Feliciello, A. and Perrino, C.
PLoS ONE 11 (5): e0154076. 2 May 2016

Contemporary use and results of intra-aortic balloon pump counterpulsation.
Gargiulo, G., Stabile, E., Perrino, C., Scudiero, F., Scudiero, L., Schiattarella, G.G., Franzone, A., Sannino, A., Giugliano, G., Trimarco, B. and Esposito, G.
Minerva Cardioangiologica 64 (1): 84-91. February 2016

2015

Dermcidin: a skeletal muscle myokine modulating cardiomyocyte survival and infarct size after coronary artery ligation.
Esposito, G., Schiattarella, G.G., Perrino, C., Cattaneo, F., Pironti, G., Franzone, A., Gargiulo, G., Magliulo, F., Serino, F., Carotenuto, G., Sannino, A., Ilardi, F., Scudiero, F., Brevetti, L, Oliveti, M., Giugliano, G., Del Giudice, C., Ciccarelli, M., Renzone, G., Scaloni, A., Zambrano, N. and Trimarco, B.
Cardiovascular Research 107 (4): 431-441. 1 September 2015

The murine model of mucopolysaccharidosis IIIB develops cardiopathies over time leading to heart failure.
Schiattarella, G.G., Cerulo, G., De Pasquale, V., Cocchiaro, P., Paciello, O., Avallone, L., Belfiore, M.P., Iacobellis, F., Di Napoli, D., Magliulo, F., Perrino, C., Trimarco, B., Esposito, G., Di Natale, P. and Pavone, L.M.
PLoS ONE 10 (7): e0131662. 6 July 2015

Effects of a new combination of nutraceuticals with Morus alba on lipid profile, insulin sensitivity and endotelial function in dyslipidemic subjects. A cross-over, randomized, double-blind trial.
Trimarco, V., Izzo, R., Stabile, E., Rozza, F., Santoro, M., Manzi, M.V., Serino, F., Schiattarella, G.G., Esposito, G. and Trimarco, B.
High Blood Pressure & Cardiovascular Prevention 22 (2): 149-154. June 2015

Primary percutaneous coronary intervention in a patient with acute inferior myocardial infarction and agenesis of right coronary artery. "In search of a coronary ostium".
Schiattarella, G.G., Magliulo, F., Palma, V., Esposito, G. and Cirillo, P.
Cardiology and Angiology 3 (3): 157-161. 27 April 2015

Inhibition of hypertrophy is a good therapeutic strategy in ventricular pressure overload.
Schiattarella, G.G. and Hill, J.A.
Circulation 131 (16): 1435-47. 21 April 2015

Response to Crozatier and Ventura-Clapier.
Schiattarella, G.G. and Hill, J.A.
Circulation 131 (16): 1457. 21 April 2015

Prevalence and characteristics of true and apparent treatment resistant hypertension in the Campania Salute Network.
Izzo, R., Stabile, E., Esposito, G., Trimarco, V., De Marco, M., Sica, A., Manzi, M.V., Gargiulo, G., Schiattarella, G., Rozza, F., De Luca, N. and de Simone, G.
International Journal of Cardiology 184 : 417-419. 1 April 2015

Novel molecular approaches in heart failure: seven trans-membrane receptors signaling in the heart and circulating blood leukocytes.
Schiattarella, G.G., Magliulo, F., Cattaneo, F., Gargiulo, G., Sannino, A., Franzone, A., Oliveti, M., Perrino, C., Trimarco, B. and Esposito, G.
Frontiers in Cardiovascular Medicine 2 : 13. 16 March 2015

2014

Cerebral embolic lesions detected with diffusion-weighted magnetic resonance imaging following carotid artery stenting: a meta-analysis of 8 studies comparing filter cerebral protection and proximal balloon occlusion.
Stabile, E., Sannino, A., Schiattarella, G.G., Gargiulo, G., Toscano, E., Brevetti, L., Scudiero, F., Giugliano, G., Perrino, C., Trimarco, B. and Esposito, G.
JACC: Cardiovascular Interventions 7 (10): 1177-1183. October 2014

Meta-analysis of mortality outcomes and mitral regurgitation evolution in 4,839 patients having transcatheter aortic valve implantation for severe aortic stenosis.
Sannino, A., Losi, M.A., Schiattarella, G.G., Gargiulo, G., Perrino, C., Stabile, E., Toscano, E., Giugliano, G., Brevetti, L., Franzone, A., Cirillo, P., Imbriaco, M., Trimarco, B. and Esposito, G.
American Journal of Cardiology 114 (6): 875-882. 15 September 2014

Epigenetic switch at Atp2a2 and Myh7 gene promoters in pressure overload-induced heart failure.
Angrisano, T., Schiattarella, G.G., Keller, S., Pironti, G., Florio, E., Magliulo, F., Bottino, R., Pero, R., Lembo, F., Avvedimento, E.V., Esposito, G., Trimarco, B., Chiariotti, L. and Perrino, C.
PLoS ONE 9 (9): e106024. 2 September 2014

Increased mortality after transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis and low ejection fraction: a meta-analysis of 6898 patients.
Sannino, A., Gargiulo, G., Schiattarella, G.G., Brevetti, L., Perrino, C., Stabile, E., Losi, M.A., Toscano, E., Giugliano, G., Scudiero, F., Chiacchio, E., Trimarco, B. and Esposito, G.
International Journal of Cardiology 176 (1): 32-39. September 2014

Genetic deletion in uncoupling protein 3 augments (18)F-fluorodeoxyglucose cardiac uptake in the ischemic heart.
Gargiulo, S., Petretta, M.P., Greco, A., Panico, M., Larobina, M., Gramanzini, M., Schiattarella, G.G., Esposito, G., Petretta, M., Brunetti, A. and Cuocolo, A.
BMC Cardiovascular Disorders 14 : 98. 8 August 2014

MicroRNA-133 modulates the β(1)-adrenergic receptor transduction cascade.
Castaldi, A., Zaglia, T., Di Mauro, V., Carullo, P., Viggiani, G., Borile, G., Di Stefano, B., Schiattarella, G.G., Gualazzi, M.G., Elia, L., Stirparo, G.G., Colorito, M.L., Pironti, G., Kunderfranco, P., Esposito, G., Bang, M.L., Mongillo, M., Condorelli, G. and Catalucci, D.
Circulation Research 115 (2): 273-283. 7 July 2014

The pitfalls of managing thrombosis of an Absorb(TM)-treated bifurcation.
Schiattarella, G.G., Magliulo, F., D'Alise, G., Mannacio, V., Ilardi, F., Trimarco, B., Esposito, G. and Cirillo, P.
International Journal of Cardiology 174 (3): e93-e95. 1 July 2014

Nuove strategie farmacologiche per la sindrome di Marfan: dai modelli animali all'uomo [Novel pharmacological strategies for aortic dilation in Marfan syndrome: from mouse models to human patients].
Perrino, C., Schiattarella, G.G., Bottino, R., Magliulo, F., Oliveti, M., Esposito, G. and Trimarco, B.
Giornale Italiano di Cardiologia 15 (7): 408-417. July 2014

Cardiac side effects of chemotherapy: state of art and strategies for a correct management.
Perrino, C., Schiattarella, G.G., Magliulo, F., Ilardi, F., Carotenuto, G., Gargiulo, G., Serino, F., Ferrone, M., Scudiero, F., Carbone, A., Trimarco, B. and Esposito, G.
Current Vascular Pharmacology 12 (1): 106-116. 27 March 2014

Physical activity in the prevention of peripheral artery disease in the elderly.
Schiattarella, G.G., Perrino, C., Magliulo, F., Carbone, A., Bruno, A.G., De Paulis, M., Sorropago, A., Corrado, R.V., Bottino, R., Menafra, G., Abete, R., Toscano, E., Giugliano, G., Trimarco, B. and Esposito, G.
Frontiers in Physiology 5 : 12. 3 March 2014

tURn the lights on: mitochondrial transport-RNAs and cardiovascular disease.
Schiattarella, G.G., Trimarco, B., Perrino, C. and Esposito, G.
Journal of the American Heart Association 3 (1): e000757. 27 January 2014

2013

Transradial approach for the endovascular treatment of type I endoleak after aortic aneurysm repair: a case report.
Schiattarella, G.G., Magliulo, F., Laurino, F.I., Bottino, R., Bruno, A.G., De Paulis, M., Sorropago, A., Perrino, C., Amato, B., Leosco, D., Trimarco, B. and Esposito, G.
BMC Surgery 13 (Suppl 2): S47. 8 October 2013

Effects of successful percutaneous lower extremity revascularization on cardiovascular outcome in patients with peripheral arterial disease.
Giugliano, G., Di Serafino, L., Perrino, C., Schiano, V., Laurenzano, E., Cassese, S., De Laurentis, M., Schiattarella, G.G., Brevetti, L., Sannino, A., Gargiulo, G., Franzone, A., Indolfi, C., Piscione, F., Abdelilah-Seyfried, S. and Esposito, G.
International Journal of Cardiology 167 (6): 2566-2571. 10 September 2013

Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure.
Perrino, C., Schiattarella, G.G., Sannino, A., Pironti, G., Petretta, M.P., Cannavo, A., Gargiulo, G., Ilardi, F., Magliulo, F., Franzone, A., Carotenuto, G., Serino, F., Altobelli, G.G., Cimini, V., Cuocolo, A., Lombardi, A., Goglia, F., Indolfi, C., Trimarco, B. and Esposito, G.
Journal of the American Heart Association 2 (3): e000086. 20 May 2013

Unexpected preserved brain perfusion imaging despite severe and diffuse atherosclerosis of supra-aortic trunks.
Gargiulo, G., Tortora, F., Cirillo, M., Perrino, C., Schiattarella, G.G., Trimarco, B. and Esposito, G.
Cardiovascular Journal of Africa 24 (3): e12-e14. 23 April 2013

A collagen membrane-based engineered heart tissue improves cardiac function in ischemic rat hearts.
Sandri, M., Rizzi, R., Schiattarella, G.G., Levialdi Ghiron, J.H., Latronico, M.V.G., Pironti, G., Chiariello, G.A., Esposito, G., Tampieri, A. and Condorelli, G.
Bioinspired Biomimetic and Nanobiomaterials 2 (1): 20-27. March 2013

2012

Abdominal aortic aneurysm in patients affected by intermittent claudication: prevalence and clinical predictors.
Giugliano, G., Laurenzano, E., Rengo, C., De Rosa, G., Brevetti, L., Sannino, A., Perrino, C., Chiariotti, L., Schiattarella, G.G., Serino, F., Ferrone, M., Scudiero, F., Carbone, A., Sorropago, A., Amato, B., Trimarco, B. and Esposito, G.
BMC Surgery 12 (Suppl 1): S17. 15 November 2012

Ankle/brachial index to everyone.
Giugliano, G., Sannino, A., Brevetti, L., Perrino, C., Schiattarella, G.G., Franzone, A., Serino, F., Ferrone, M., Scudiero, F., Carbone, A., De Paulis, M., Izzo, R., Amato, B., Trimarco, B. and Esposito, G.
BMC Surgery 12 (Suppl 1): S18. 15 November 2012

Endovascular treatment of lower extremity arteries is associated with an improved outcome in diabetic patients affected by intermittent claudication.
Giugliano, G., Perrino, C., Schiano, V., Brevetti, L., Sannino, A., Schiattarella, G.G., Gargiulo, G., Serino, F., Ferrone, M., Scudiero, F., Carbone, A., Bruno, A., Amato, B., Trimarco, B. and Esposito, G.
BMC Surgery 12 (Suppl 1): S19. 15 November 2012

Use of statins in lower extremity artery disease: a review.
Gargiulo, G., Giugliano, G., Brevetti, L., Sannino, A., Schiattarella, G.G., Serino, F., Carbone, A., Scudiero, F., Ferrone, M., Corrado, R., Izzo, R., Chiariotti, L., Perrino, C., Amato, B., Trimarco, B. and Esposito, G.
BMC Surgery 12 (Suppl 1): S15. 15 November 2012

Statins and the elderly: recent evidence and current indications.
Schiattarella, G.G., Perrino, C., Magliulo, F., Ilardi, F., Serino, F., Trimarco, V., Izzo, R., Amato, B., Terranova, C., Cardin, F., Militello, C., Leosco, D., Trimarco, B. and Esposito, G.
Aging Clinical and Experimental Research 24 (Suppl 3): 47-55. June 2012

2011

Endovascular treatment of carotid artery stenosis: evidences from randomized controlled trials and actual indications.
Ilardi, F., Magliulo, F., Gargiulo, G., Schiattarella, G.G., Carotenuto, G., Serino, F., Ferrone, M., Visco, E., Scudiero, F., Carbone, A., Perrino, C., Trimarco, B. and Esposito, G.
Monaldi Archives for Chest Disease 76 (4): 183-191. December 2011

EGFR trans-activation by urotensin II receptor is mediated by β-arrestin recruitment and confers cardioprotection in pressure overload-induced cardiac hypertrophy.
Esposito, G., Perrino, C., Cannavo, A., Schiattarella, G.G., Borgia, F., Sannino, A., Pironti, G., Gargiulo, G., Di Serafino, L., Franzone, A., Scudiero, L., Grieco, P., Indolfi, C. and Chiariello, M.
Basic Research in Cardiology 106 (4): 577-589. July 2011

Cardiovascular effects of treadmill exercise in physiological and pathological preclinical settings.
Perrino, C., Gargiulo, G., Pironti, G., Franzone, A., Scudiero, L., De Laurentis, M., Magliulo, F., Ilardi, F., Carotenuto, G., Schiattarella, G.G. and Esposito, G.
American Journal of Physiology Heart and Circulatory Physiology 300 (6): H1983-H1989. June 2011

Balancing hemorrhagic and thrombotic complications in a patient with a very late paclitaxel-eluting stent thrombosis: a clinical case report.
Esposito, G., Cassese, S., Gargiulo, G., Sannino, A., Schiattarella, G.G., Piscione, F. and Chiariello, M.
Journal of Cardiovascular Medicine 12 (5): 366-369. May 2011

Total occlusion of the abdominal aorta in a patient with renal failure and refractory hypertension: a case report.
Perrino, C., Scudiero, L., Petretta, M.P., Schiattarella, G.G., De Laurentis, M., Ilardi, F., Magliulo, F., Carotenuto, G. and Esposito, G.
Monaldi Archives for Chest Disease 76 (1): 43-46. March 2011

2010

AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress.
Perrino, C., Feliciello, A., Schiattarella, G.G., Esposito, G., Guerriero, R., Zaccaro, L., Del Gatto, A., Saviano, M., Garbi, C., Carangi, R., Di Lorenzo, E., Donato, G., Indolfi, C., Avvedimento, V.E. and Chiariello, M.
Cardiovascular Research 88 (1): 101-110. 1 October 2010

(Zebra) fishing for relevant genes in heart regeneration.
Perrino, C. and Schiattarella, G.G.
Journal of Cardiovascular Medicine 11 (9): 631-632. September 2010

AngioJet® rheolytic thrombectomy for acute superficial femoral artery stent or femoropopliteal by-pass thrombosis.
Borgia, F., Di Serafino, L., Sannino, A., Gargiulo, G., Schiattarella, G.G., De Laurentis, M., Scudiero, L., Perrino, C., Piscione, F., Esposito, G. and Chiariello, M.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 74 (2): 76-81. June 2010

Nuovi concetti nella segnalazione β-adrenergica: prospettive terapeutiche per lo scompenso cardiaco [Novel concepts in beta-adrenergic receptor signaling: therapeutic options for heart failure].
Schiattarella, G.G., Perrino, C., Gargiulo, G., Sorrentino, S., Franzone, A., Capretti, G., Esposito, G. and Chiariello, M.
Giornale Italiano di Cardiologia 11 (3): 221-228. March 2010

Induction of mitogen-activated protein kinases is proportional to the amount of pressure overload.
Esposito, G., Perrino, C., Schiattarella, G.G., Belardo, L., di Pietro, E., Franzone, A., Capretti, G., Gargiulo, G., Pironti, G., Cannavo, A., Sannino, A., Izzo, R. and Chiariello, M.
Hypertension 55 (1): 137-143. January 2010

2009

Endovascular repair for isolated iliac artery aneurysms: case report and review of the current literature.
Esposito, G., Franzone, A., Cassese, S., Schiattarella, G.G., Capretti, G., Pironti, G., Di Serafino, L., Perrino, C., Piscione, F. and Chiariello, M.
Journal of Cardiovascular Medicine 10 (11): 861-865. November 2009

Rotational atherectomy for the treatment of isolated femoral artery traumatic lesion: a case report.
Esposito, G., Di Serafino, L., Gargiulo, G., Sannino, A., Schiattarella, G.G., Franzone, A., Perrino, C. and Chiariello, M.
Monaldi Archives for Chest Disease 72 (3): 148-151. September 2009

The second cAMP messenger and cardiac function regulation: the role of adenylate cyclase [Il secondo messaggero cAMP e la regolazione della funzione cardiaca: ruolo dell'adenilato ciclasi].
Capretti, G., Franzone, A., Schiattarella, G.G., Gargiulo, G., Sannino, A., Sorrentino, S., Perrino, C., Esposito, G. and Chiariello, M.
Trends in Medicine 9 (3): 129-136. July 2009

Biological effects of statins in atherosclerosis [Gli effetti biologici delle statine nella malattia aterosclerotica].
Franzone, A., Schiattarella, G.G., Capretti, G., Sorrentino, S., Pironti, G., Sannino, A., Perrino, C., Esposito, G. and Chiariello, M.
Trends in Medicine 9 (1): 19-26. January 2009

2007

Identification of the ligands of protein interaction domains through a functional approach.
Caratù, G., Allegra, D., Bimonte, M., Schiattarella, G.G., D'Ambrosio, C., Scaloni, A., Napolitano, M., Russo, T. and Zambrano, N.
Molecular & Cellular Proteomics 6 (2): 333-345. February 2007