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2024

EU-LIFE charter of independent life science research institutes.
Superti-Furga, G. and Agostinho, M. and Bury, J. and Cook, S. and Durinx, C. and Ender, A. and van Luenen, H. and Lund, A.H. and Medema, R.H. and Miączyńska, M. and Nickel, D. and Pelicci, P.G. and Puisieux, A. and Ripatti, S. and Sander, M. and Schubeler, D. and Serrano, L. and Sommer, T. and Sonne-Hansen, K. and Tomančák, P. and Vives, J. and Vontas, J. and Bettencourt-Dias, M.
FEBS Letters 21 March 2024

A vascularized 3D model of the human pancreatic islet for ex vivo study of immune cell-islet interaction.
Bender, R.H.F. and O'Donnell, B.T. and Shergill, B. and Pham, B.Q. and Tahmouresie, S. and Sanchez, C.N. and Juat, D.J. and Hatch, M.M.S. and Shirure, V.S. and Wortham, M. and Nguyen-Ngoc, K.V. and Jun, Y. and Gaetani, R. and Christman, K.L. and Teyton, L. and George, S.C. and Sander, M. and Hughes, C.C.W.
Biofabrication 16 (2): 025001. 11 January 2024

2023

Gene editing to improve pancreatic beta cell yield in directed differentiation of human pluripotent stem cells.
The regents of the university of California.
WO-2023137235-A3. 20 July 2023

Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding.
Urizar, A.I. and Prause, M. and Ingerslev, L.R. and Wortham, M. and Sui, Y. and Sander, M. and Williams, K. and Barrès, R. and Larsen, M.R. and Christensen, G.L. and Billestrup, N.
Cell Death & Disease 14 (7): 399. 5 July 2023

Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetes.
Wang, G. and Chiou, J. and Zeng, C. and Miller, M. and Matta, I. and Han, J.Y. and Kadakia, N. and Okino, M.L. and Beebe, E. and Mallick, M. and Camunas-Soler, J. and Dos Santos, T. and Dai, X.Q. and Ellis, C. and Hang, Y. and Kim, S.K. and MacDonald, P.E. and Kandeel, F.R. and Preissl, S. and Gaulton, K.J. and Sander, M.
Nature Genetics 55 (6): 984-994. June 2023

Understanding cell fate acquisition in stem-cell-derived pancreatic islets using single-cell multiome-inferred regulomes.
Zhu, H. and Wang, G. and Nguyen-Ngoc, K.V. and Kim, D. and Miller, M. and Goss, G. and Kovsky, J. and Harrington, A.R. and Saunders, D.C. and Hopkirk, A.L. and Melton, R. and Powers, A.C. and Preissl, S. and Spagnoli, F.M. and Gaulton, K.J. and Sander, M.
Developmental Cell 58 (9): 727-743. 8 May 2023

Nutrient regulation of the islet epigenome controls adaptive insulin secretion.
Wortham, M. and Liu, F. and Harrington, A.R. and Fleischman, J.Y. and Wallace, M. and Mulas, F. and Mallick, M. and Vinckier, N.K. and Cross, B.R. and Chiou, J. and Patel, N.A. and Sui, Y. and McGrail, C. and Jun, Y. and Wang, G. and Jhala, U.S. and Schüle, R. and Shirihai, O.S. and Huising, M.O. and Gaulton, K.J. and Metallo, C.M. and Sander, M.
Journal of Clinical Investigation 133 (8): e165208. 17 April 2023

Matters arising: Insufficient evidence that pancreatic β cells are derived from adult ductal Neurog3-expressing progenitors.
Magenheim, J. and Maestro, M.A. and Sharon, N. and Herrera, P.L. and Murtaugh, L.C. and Kopp, J. and Sander, M. and Gu, G. and Melton, D.A. and Ferrer, J. and Dor, Y.
Cell Stem Cell 30 (4): 488-497. 6 April 2023

The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits.
Costanzo, M.C. and von Grotthuss, M. and Massung, J. and Jang, D. and Caulkins, L. and Koesterer, R. and Gilbert, C. and Welch, R.P. and Kudtarkar, P. and Hoang, Q. and Boughton, A.P. and Singh, P. and Sun, Y. and Duby, M. and Moriondo, A. and Nguyen, T. and Smadbeck, P. and Alexander, B.R. and Brandes, M.K. and Carmichael, M. and Dornbos, P. and Green, T. and Huellas-Bruskiewicz, K.C. and Ji, Y. and Kluge, A. and McMahon, A.C. and Mercader, J.M. and Ruebenacker, O. and Sengupta, S. and Spalding, D. and Taliun, D. and Smith, P. and Thomas, M.K. and Akolkar, B. and Brosnan, M.J. and Cherkas, A. and Chu, A.Y. and Fauman, E.B. and Fox, C.S. and Kamphaus, T.N. and Miller, M.R. and Nguyen, L. and Parsa, A. and Reilly, D.F. and Ruetten, H. and Wholley, D. and Zaghloul, N.A. and Abecasis, G.R. and Altshuler, D. and Keane, T.M. and McCarthy, M.I. and Gaulton, K.J. and Florez, J.C. and Boehnke, M. and Burtt, N.P. and Flannick, J.
Cell Metabolism 35 (4): 695-710.e6. 4 April 2023

Integrated physiology of the exocrine and endocrine compartments in pancreatic diseases: workshop proceedings.
Mastracci, T.L. and Apte, M. and Amundadottir, L.T. and Alvarsson, A. and Artandi, S. and Bellin, M.D. and Bernal-Mizrachi, E. and Caicedo, A. and Campbell-Thompson, M. and Cruz-Monserrate, Z. and El Ouaamari, A. and Gaulton, K.J. and Geisz, A. and Goodarzi, M.O. and Hara, M. and Hull-Meichle, R.L. and Kleger, A. and Klein, A.P. and Kopp, J.L. and Kulkarni, R.N. and Muzumdar, M.D. and Naren, A.P. and Oakes, S.A. and Olesen, S.S. and Phelps, E.A. and Powers, A.C. and Stabler, C.L. and Tirkes, T. and Whitcomb, D.C. and Yadav, D. and Yong, Jing and Zaghloul, N.A. and Pandol, S.J. and Sander, M.
Diabetes 72 (4): 433-448. April 2023

2022

Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines.
Benaglio, P. and Zhu, H. and Okino, M.L. and Yan, J. and Elgamal, R. and Nariai, N. and Beebe, E. and Korgaonkar, K. and Qiu, Y. and Donovan, M.K.R. and Chiou, J. and Wang, G. and Newsome, J. and Kaur, J. and Miller, M. and Preissl, S. and Corban, S. and Aylward, A. and Taipale, J. and Ren, B. and Frazer, K.A. and Sander, M. and Gaulton, K.J.
Cell Genomics 2 (12): 100214. 14 December 2022

Systemic LSD1 inhibition prevents aberrant remodeling of metabolism in obesity.
Ramms, B. and Pollow, D.P. and Zhu, H. and Nora, C. and Harrington, A.R. and Omar, I. and Gordts, P.L.S.M. and Wortham, M. and Sander, M.
Diabetes 71 (12): 2513-2529. December 2022

Beta cell dysfunction and dedifferentiation induced by Bone Morphogenetic Protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding.
Ibarra, A. and Prause, M. and Ingerslev, L. and Wortham, M. and Sui, Y. and Sander, M. and Williams, K. and Barrès, R. and Larsen, M. and Christensen, G. and Billestrup, N.
Research Square : rs-2254065. 23 November 2022

Integrated physiology of the exocrine and endocrine compartments in pancreatic diseases.
Mastracci, T.L. and Apte, M. and Amundadottir, L.T. and Alvarsson, A. and Artandi, S. and Bellin, M.D. and Bernal-Mizrachi, E. and Caicedo, A. and Campbell-Thompson, M. and Cruz-Monserrate, Z. and El Ouaamari, A. and Gaulton, K.J. and Geisz, A. and Goodarzi, M.O. and Hara, M. and Hull-Meichle, R.L. and Kleger, A. and Klein, A.P. and Kopp, J.L. and Kulkarni, R.N. and Muzumdar, M.D. and Naren, A.P. and Oakes, S.A. and Olesen, S.S. and Phelps, E.A. and Powers, A.C. and Stabler, C.L. and Tirkes, T. and Whitcomb, D.C. and Yadav, D. and Yong, J. and Zaghloul, N.A. and Sander, M. and Pandol, S.J.
Pancreas 51 (9): 1061-1073. 1 October 2022

Every islet matters: improving the impact of human islet research.
Gloyn, Anna L and Ibberson, Mark and Marchetti, Piero and Powers, Alvin C and Rorsman, Patrik and Sander, M. and Solimena, Michele
Nature Metabolism 4 (8): 970-977. August 2022

Sizing up beta cells made from stem cells.
Nguyen-Ngoc, K.V. and Wortham, M. and Sander, M.
Nature Biotechnology 40 (7): 1006-1008. July 2022

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.
Mahajan, A. and Spracklen, C.N. and Zhang, W. and Ng, M.C.Y. and Petty, L.E. and Kitajima, H. and Yu, G.Z. and Rüeger, S. and Speidel, L. and Kim, Y.J. and Horikoshi, M. and Mercader, J.M. and Taliun, D. and Moon, S. and Kwak, S.H. and Robertson, N.R. and Rayner, N.W. and Loh, M. and Kim, B.J. and Chiou, J. and Miguel-Escalada, I. and Della Briotta Parolo, P. and Lin, K. and Bragg, F. and Preuss, M.H. and Takeuchi, F. and Nano, J. and Guo, X. and Lamri, A. and Nakatochi, M. and Scott, R.A. and Lee, J.. and Huerta-Chagoya, A. and Graff, M. and Chai, J.F. and Parra, E.J. and Yao, J. and Bielak, L.F. and Tabara, Y. and Hai, Y. and Steinthorsdottir, V. and Cook, J.P. and Kals, M. and Grarup, N. and Schmidt, E.M. and Pan, I. and Sofer, T. and Wuttke, M. and Sarnowski, C. and Gieger, C. and Nousome, D. and Trompet, S. and Long, J. and Sun, M. and Tong, L. and Chen, W.M. and Ahmad, M. and Noordam, R. and Lim, V.J.Y. and Tam, C.H.T. and Joo, Y.Y. and Chen, C.H. and Raffield, L.M. and Lecoeur, C. and Prins, B.P. and Nicolas, A. and Yanek, L.R. and Chen, G. and Jensen, R.A. and Tajuddin, S. and Kabagambe, E.K. and An, P. and Xiang, A.H. and Choi, H.S. and Cade, B.E. and Tan, J. and Flanagan, J. and Abaitua, F. and Adair, L.S. and Adeyemo, A. and Aguilar-Salinas, C.A. and Akiyama, M. and Anand, S.S. and Bertoni, A. and Bian, Z. and Bork-Jensen, J. and Brandslund, I. and Brody, J.A. and Brummett, C.M. and Buchanan, T.A. and Canouil, M. and Chan, J.C.N. and Chang, L.C. and Chee, M.L. and Chen, J. and Chen, S.H. and Chen, Y.T. and Chen, Z. and Chuang, L.M. and Cushman, M. and Das, S.K. and de Silva, H.J. and Dedoussis, G. and Dimitrov, L. and Doumatey, A.P. and Du, S. and Duan, Q. and Eckardt, K.U. and Emery, L.S. and Evans, D.S. and Evans, M.K. and Fischer, K. and Floyd, J.S. and Ford, I. and Fornage, M. and Franco, O.H. and Frayling, T.M. and Freedman, B.I. and Fuchsberger, C. and Genter, P. and Gerstein, H.C. and Giedraitis, V. and González-Villalpando, C. and González-Villalpando, M.E. and Goodarzi, M.O. and Gordon-Larsen, P. and Gorkin, D. and Gross, M. and Guo, Y. and Hackinger, S. and Han, S. and Hattersley, A.T. and Herder, C. and Howard, A.G. and Hsueh, W. and Huang, M. and Huang, W. and Hung, Y.J. and Hwang, M.Y. and Hwu, C.M. and Ichihara, S. and Ikram, M.A. and Ingelsson, M. and Islam, M.T. and Isono, M. and Jang, H.M. and Jasmine, F. and Jiang, G. and Jonas, J.B. and Jørgensen, M.E. and Jørgensen, T. and Kamatani, Y. and Kandeel, F.R. and Kasturiratne, A. and Katsuya, T. and Kaur, V. and Kawaguchi, T. and Keaton, J.M. and Kho, A.N. and Khor, C.C. and Kibriya, M.G. and Kim, D.H. and Kohara, K. and Kriebel, J. and Kronenberg, F. and Kuusisto, J. and Läll, K. and Lange, L.A. and Lee, M.S. and Lee, N.R. and Leong, A. and Li, L. and Li, Y. and Li-Gao, R. and Ligthart, S. and Lindgren, C.M. and Linneberg, A. and Liu, C.T. and Liu, J. and Locke, A.E. and Louie, T. and Luan, J. and Luk, A.O. and Luo, X. and Lv, J. and Lyssenko, V. and Mamakou, V. and Mani, K.R. and Meitinger, T. and Metspalu, A. and Morris, A.D. and Nadkarni, G.N. and Nadler, J.L. and Nalls, M.A. and Nayak, U. and Nongmaithem, S.S. and Ntalla, I. and Okada, Y. and Orozco, L. and Patel, S.R. and Pereira, M.A. and Peters, A. and Pirie, F.J. and Porneala, B. and Prasad, G. and Preissl, S. and Rasmussen-Torvik, L.J. and Reiner, A.P. and Roden, M. and Rohde, R. and Roll, K. and Sabanayagam, C. and Sander, M. and Sandow, K. and Sattar, N. and Schönherr, S. and Schurmann, C. and Shahriar, M. and Shi, J. and Shin, D.M. and Shriner, D. and Smith, J.A. and So, W.Y. and Stančáková, A. and Stilp, A.M. and Strauch, K. and Suzuki, K. and Takahashi, A. and Taylor, K.D. and Thorand, B. and Thorleifsson, G. and Thorsteinsdottir, U. and Tomlinson, B. and Torres, J.M. and Tsai, F.J. and Tuomilehto, J. and Tusie-Luna, T. and Udler, M.S. and Valladares-Salgado, A. and van Dam, R.M. and van Klinken, J.B. and Varma, R. and Vujkovic, M. and Wacher-Rodarte, N. and Wheeler, E. and Whitsel, E.A. and Wickremasinghe, A.R. and van Dijk, K.W. and Witte, D.R. and Yajnik, C.S. and Yamamoto, K. and Yamauchi, T. and Yengo, L. and Yoon, K. and Yu, C. and Yuan, J.M. and Yusuf, S. and Zhang, L. and Zheng, W. and Raffel, L.J. and Igase, M. and Ipp, E. and Redline, S. and Cho, Y.S. and Lind, L. and Province, M.A. and Hanis, C.L. and Peyser, P.A. and Ingelsson, E. and Zonderman, A.B. and Psaty, B.M. and Wang, Y.X. and Rotimi, C.N. and Becker, D.M. and Matsuda, F. and Liu, Y. and Zeggini, E. and Yokota, M. and Rich, S.S. and Kooperberg, C. and Pankow, J.S. and Engert, J.C. and Chen, Y.D.I. and Froguel, P. and Wilson, J.G. and Sheu, W.H.H. and Kardia, S.L.R. and Wu, J.Y. and Hayes, M.G. and Ma, R.C.W. and Wong, T.Y. and Groop, L. and Mook-Kanamori, D.O. and Chandak, G.R. and Collins, F.S. and Bharadwaj, D. and Paré, G. and Sale, M.M. and Ahsan, H. and Motala, A.A. and Shu, X.O. and Park, K.S. and Jukema, J.W. and Cruz, M. and McKean-Cowdin, R. and Grallert, H. and Cheng, C.Y. and Bottinger, E.P. and Dehghan, A. and Tai, E.S. and Dupuis, J. and Kato, N. and Laakso, M. and Köttgen, A. and Koh, W.P. and Palmer, C.N A. and Liu, S. and Abecasis, G. and Kooner, J.S. and Loos, R.J.F. and North, K.E. and Haiman, C.A. and Florez, J.C. and Saleheen, D. and Hansen, T. and Pedersen, O. and Mägi, R. and Langenberg, C. and Wareham, N.J. and Maeda, S. and Kadowaki, T. and Lee, J. and Millwood, I.Y. and Walters, R.G. and Stefansson, K. and Myers, S.R. and Ferrer, J. and Gaulton, K.J. and Meigs, J.B. and Mohlke, K.L. and Gloyn, A.L. and Bowden, D.W. and Below, J.E. and Chambers, J.C. and Sim, X. and Boehnke, M. and Rotter, J.I. and McCarthy, M.I. and Morris, A.P.
Nature Genetics 54 (5): 560-572. May 2022

Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance.
Shum, M. and Segawa, M. and Gharakhanian, R. and Viñuela, A. and Wortham, M. and Baghdasarian, S. and Wolf, D.M. and Sereda, S.B. and Nocito, L. and Stiles, L. and Zhou, Z. and Gutierrez, V. and Sander, M. and Shirihai, O.S. and Liesa, M.
Molecular Metabolism 55 : 101403. January 2022

Heterogeneity of diabetes: β-cells, phenotypes, and precision medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases.
Cefalu, W.T. and Andersen, D.K. and Arreaza-Rubín, G. and Pin, C.L. and Sato, S. and Verchere, C.B. and Woo, M. and Rosenblum, N.D.
Diabetes 71 (1): 1–22. January 2022

2021

Heterogeneity of diabetes: β-cells, phenotypes, and precision medicine: proceedings of an international symposium of the canadian institutes of Health Research’s Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases.
Cefalu, W.T. and Andersen, D.K. and Arreaza-Rubín, G. and Pin, C.L. and Sato, S. and Verchere, C.B. and Woo, M. and Rosenblum, N.D. and Rosenblum, N. and Cefalu, W. and Andersen, D.K. and Arreaza-Rubín, G. and Dhara, C. and James, S.P. and Makarchuk, M.J. and Pin, C.L. and Sato, S. and Verchere, B. and Woo, M. and Powers, A. and Estall, J. and Hoesli, C. and Millman, J. and Linnemann, A. and Johnson, J. and Pin, C.L. and Hawkins, M. and Woo, M. and Gloyn, A. and Cefalu, W. and Rosenblum, N. and Huising, M.O. and Benninger, R.K.P. and Almaça, J. and Hull-Meichle, R.L. and MacDonald, P. and Lynn, F. and Melero-Martin, J. and Yoshihara, E. and Stabler, C. and Sander, M. and Evans-Molina, C. and Engin, F. and Thompson, P. and Shalev, A. and Redondo, M.J. and Nadeau, K. and Bellin, M. and Udler, M.S. and Dennis, J. and Dash, S. and Zhou, W. and Snyder, M. and Booth, G. and Butte, A. and Florez, J.
Canadian Journal of Diabetes 45 (8): 697-713. December 2021

Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors.
Geusz, R.J. and Wang, A. and Lam, D.K. and Vinckier, N.K. and Alysandratos, K.D. and Roberts, D.A. and Wang, J. and Kefalopoulou, S. and Ramirez, A. and Qiu, Y. and Chiou, J. and Gaulton, K.J. and Ren, B. and Kotton, D.N. and Sander, M.
Nature Communications 12 (1): 6636. 17 November 2021

Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation.
Heller, S. and Li, Z. and Lin, Q. and Geusz, R. and Breunig, M. and Hohwieler, M. and Zhang, X. and Nair, G.G. and Seufferlein, T. and Hebrok, M. and Sander, M. and Julier, C. and Kleger, A. and Costa, I.G.
Communications Biology 4 (1): 1298. 17 November 2021

A multi-omics roadmap of β-cell failure in type 2 diabetes mellitus.
Wang, G. and Sander, M.
Nature Reviews Endocrinology 17 (11): 641-642. November 2021

Mutations and variants of ONECUT1 in diabetes.
Philippi, A. and Heller, S. and Costa, I.G. and Senée, V. and Breunig, M. and Li, Z. and Kwon, G. and Russell, R. and Illing, A. and Lin, Q. and Hohwieler, M. and Degavre, A. and Zalloua, P. and Liebau, S. and Schuster, M. and Krumm, Jo. and Zhang, X. and Geusz, R. and Benthuysen, J. R. and Wang, A. and Chiou, J. and Gaulton, K. and Neubauer, H. and Simon, E. and Klein, T. and Wagner, M. and Nair, G. and Besse, C. and Dandine-Roulland, C. and Olaso, R. and Deleuze, J.F. and Kuster, B. and Hebrok, M. and Seufferlein, T. and Sander, M. and Boehm, B.O. and Oswald, F. and Nicolino, M. and Julier, C. and Kleger, A.
Nature Medicine 27 (11): 1928-1940. November 2021

What is a β cell? - Chapter I in the Human Islet Research Network (HIRN) review series.
Kaestner, K.H. and Campbell-Thompson, M. and Dor, Y. and Gill, R.G. and Glaser, B. and Kim, S.K. and Sander, M. and Stabler, C. and Stewart, A.F. and Powers, A.C.
Molecular Metabolism 53 : 101323. November 2021

Career advancement for women in diabetes-related research: developing and retaining female talent.
Sandoval, D.A. and Alonso, L.C. and Gannon, M. and Sander, M. and Sussel, L. and Reusch, J.E.B.
Diabetes 70 (8): 1634-1637. 1 August 2021

Career advancement for women in diabetes-related research: developing and retaining female talent.
Sandoval, D.A. and Alonso, L.C. and Gannon, M. and Sander, M. and Sussel, L. and Reusch, J.E.B.
Diabetes Care 44 (8): 1744-1747. August 2021

Transcriptional mechanisms of pancreatic β-cell maturation and functional adaptation.
Wortham, M. and Sander, M.
Trends in Endocrinology and Metabolism 32 (7): 474-487. July 2021

Interpreting type 1 diabetes risk with genetics and single-cell epigenomics.
Chiou, J. and Geusz, R.J. and Okino, M.L. and Han, J.Y. and Miller, M. and Melton, R. and Beebe, E. and Benaglio, P. and Huang, S. and Korgaonkar, K. and Heller, S. and Kleger, A. and Preissl, S. and Gorkin, D.U. and Sander, M. and Gaulton, K.J.
Nature 594 (7863): 398-402. 17 June 2021

Transformation of SOX9(+) cells by Pten deletion synergizes with steatotic liver injury to drive development of hepatocellular and cholangiocarcinoma.
Chen, J. and Debebe, A. and Zeng, N. and Kopp, J. and He, L. and Sander, M. and Stiles, B.L.
Scientific Reports 11 (1): 11823. 3 June 2021

Single-cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk.
Chiou, J. and Zeng, C. and Cheng, Z. and Han, J.Y. and Schlichting, M. and Miller, M. and Mendez, R. and Huang, S. and Wang, J. and Sui, Y. and Deogaygay, A. and Okino, M.L. and Qiu, Y. and Sun, Y. and Kudtarkar, P. and Fang, R. and Preissl, S. and Sander, M. and Gorkin, D.U. and Gaulton, K.J.
Nature Genetics 53 (4): 455-466. April 2021

Systematic analysis of binding of transcription factors to noncoding variants.
Yan, J. and Qiu, Y. and Ribeiro Dos Santos, A.M. and Yin, Y. and Li, Y.E. and Vinckier, N. and Nariai, N. and Benaglio, P. and Raman, A. and Li, X. and Fan, S. and Chiou, J. and Chen, F. and Frazer, K.A. and Gaulton, K.J. and Sander, M. and Taipale, Ju. and Ren, B.
Nature 591 (7848): 147-151. March 2021

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development.
Geusz, R.J. and Wang, A. and Chiou, J. and Lancman, J.J. and Wetton, N. and Kefalopoulou, S. and Wang, J. and Qiu, Y. and Yan, J. and Aylward, A. and Ren, B. and Dong, P.D.S. and Gaulton, K.J. and Sander, M.
eLife 10 : e59067. 5 February 2021

Inferring time series chromatin states for promoter-enhancer pairs based on Hi-C data.
Miko, H. and Qiu, Y. and Gaertner, B. and Sander, M. and Ohler, U.
BMC Genomics 22 (1): 84. 28 January 2021

2020

A human ESC-based screen identifies a role for the translated lncRNA LINC00261 in pancreatic endocrine differentiation.
Gaertner, B. and van Heesch, S. and Schneider-Lunitz, V. and Schulz, J.F. and Witte, F. and Blachut, S. and Nguyen, S. and Wong, R. and Matta, I. and Hübner, N. and Sander, M.
eLife 9 : e58659. 3 August 2020

A functional screen of translated pancreatic lncRNAs identifies a microprotein-independent role for LINC00261 in endocrine cell differentiation.
Gaertner, B. and van Heesch, S. and Schneider-Lunitz, V. and Schulz, J.F. and Witte, F. and Blachut, S. and Nguyen, S. and Wong, R. and Matta, I. and Hubner, N. and Sander, M.
bioRxiv : 2020.04.28.062679. 29 April 2020

LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development.
Vinckier, N.K. and Patel, N.A. and Geusz, R.J. and Wang, A. and Wang, J. and Matta, I. and Harrington, A.R. and Wortham, M. and Wetton, N. and Wang, J. and Jhala, U.S. and Rosenfeld, M.G. and Benner, C.W. and Shih, H.P. and Sander, M.
Nature Communications 11 (1): 2082. 29 April 2020

PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response.
Ye, J. and Huang, A. and Wang, H. and Zhang, A.M.Y. and Huang, X. and Lan, Q. and Sato, T. and Goyama, S. and Kurokawa, M. and Deng, C. and Sander, M. and Schaeffer, D.F. and Li, W. and Kopp, J.L. and Xie, R.
Cell death and disease 11 (3): 187. 16 March 2020

2019

A network of microRNAs acts to promote cell cycle exit and differentiation of human pancreatic endocrine cells.
Jin, W. and Mulas, F. and Gaertner, B. and Sui, Y. and Wang, J. and Matta, I. and Zeng, C. and Vinckier, N. and Wang, A. and Nguyen-Ngoc, K.V. and Chiou, J. and Kaestner, K.H. and Frazer, K.A. and Carrano, A.C. and Shih, H.P. and Sander, M.
iScience 21 : 681-694. 22 November 2019

Human stem cell models: lessons for pancreatic development and disease.
Gaertner, B. and Carrano, A.C. and Sander, M.
Genes & Development 33 (21-22): 1475-1490. 1 November 2019

In vivo-mimicking microfluidic perfusion culture of pancreatic islet spheroids.
Jun, Y. and Lee, J.S. and Choi, S. and Yang, J.H. and Sander, M. and Chung, S. and Lee, S.H.
Science Advances 5 (11): eaax4520. 1 November 2019

Differential cell susceptibilities to kras(G12D) in the setting of obstructive chronic pancreatitis.
Shi, C. and Pan, F.C. and Kim, J.N. and Washington, M.K. and Padmanabhan, C. and Meyer, C.T. and Kopp, J.L. and Sander, M. and Gannon, M. and Beauchamp, R.D. and Wright, C.V. and Means, A.L.
Cellular and molecular gastroenterology and hepatology 8 (4): 579-594. 31 October 2019

Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1β is associated with changes in expression of beta-cell maturity genes and associated histone modifications.
Ibarra Urizar, A. and Prause, M. and Wortham, M. and Sui, Y. and Thams, P. and Sander, M. and Christensen, G.L. and Billestrup, N.
Molecular and Cellular Endocrinology 496 : 110524. 1 October 2019

Nomenclature for cellular plasticity: are the terms as plastic as the cells themselves?
Mills, J.C. and Stanger, B.Z. and Sander, M.
EMBO Journal 38 (19): e103148. 1 October 2019

Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk.
Greenwald, W.W. and Chiou, J. and Yan, J. and Qiu, Y. and Dai, N. and Wang, A. and Nariai, N. and Aylward, A. and Han, J.Y. and Kadakia, N. and Regue, L. and Okino, M.L. and Drees, F. and Kramer, D. and Vinckier, N. and Minichiello, L. and Gorkin, D. and Avruch, J. and Frazer, K.A. and Sander, M. and Ren, B. and Gaulton, K.J.
Nature Communications 10 (1): 2078. 7 May 2019

Cell of origin affects tumour development and phenotype in pancreatic ductal adenocarcinoma.
Lee, A.Y.L. and Dubois, C.L. and Sarai, K. and Zarei, S. and Schaeffer, D.F. and Sander, M. and Kopp, J. L.
Gut 68 (3): 487-498. March 2019

2018

Integrated in vivo quantitative proteomics and nutrient tracing reveals age-related metabolic rewiring of pancreatic β cell function.
Wortham, M. and Benthuysen, J.R. and Wallace, M. and Savas, J.N. and Mulas, F. and Divakaruni, A.S. and Liu, F. and Albert, V. and Taylor, B.L. and Sui, Y. and Saez, E. and Murphy, A.N. and Yates, J.R. and Metallo, C.M. and Sander, M.
Cell Reports 25 (10): 2904-2918. 4 December 2018

Evaluation of different decellularization protocols on the generation of pancreas-derived hydrogels.
Gaetani, R. and Aude, S. and DeMaddalena, L.L. and Strassle, H. and Dzieciatkowska, M. and Wortham, M. and Bender, R.H.F. and Nguyen-Ngoc, K.V. and Schmid-Schöenbein, G.W. and George, S.C. and Hughes, C.C.W. and Sander, M. and Hansen, K.C. and Christman, K.L.
Tissue Engineering Part C Methods 24 (12): 697-708. December 2018

N(6)-methyladenine DNA modification in glioblastoma.
Xie, Q. and Wu, T.P. and Gimple, R.C. and Li, Z. and Prager, B.C. and Wu, Q. and Yu, Y. and Wang, P. and Wang, Y. and Gorkin, D.U. and Zhang, C. and Dowiak, A.V. and Lin, K. and Zeng, C. and Sui, Y. and Kim, L.J.Y. and Miller, T.E. and Jiang, L. and Lee, C.H. and Huang, Z. and Fang, X.. and Zhai, K. and Mack, S.C. and Sander, M. and Bao, S. and Kerstetter-Fogle, A.E. and Sloan, A.E. and Xiao, A.Z. and Rich, J.N.
Cell 175 (5): 1228-1243. 15 November 2018

Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon(+) α-cells.
Cigliola, V. and Ghila, L. and Thorel, F. and van Gurp, L. and Baronnier, D. and Oropeza, D. and Gupta, S. and Miyatsuka, T. and Kaneto, H. and Magnuson, M.A. and Osipovich, A.B. and Sander, M. and Wright, C.E.V. and Thomas, M.K. and Furuyama, K. and Chera, S. and Herrera, P.L.
Nature Cell Biology 20 (11): 1267-1277. November 2018

Epigenetics and epigenomics: implications for diabetes and obesity.
Rosen, E.D. and Kaestner, K.H. and Natarajan, R. and Patti, M.E. and Sallari, R. and Sander, M. and Susztak, K.
Diabetes 67 (10): 1923-1931. 1 October 2018

Pancreatic exocrine tissue architecture and integrity are maintained by e-cadherin during postnatal development.
Serrill, J.D. and Sander, M. and Shih, H.P.
Scientific Reports 8 (1): 13451. 7 September 2018

ETV5 regulates ductal morphogenesis with Sox9 and is critical for regeneration from pancreatitis.
Das, K.K. and Heeg, S. and Pitarresi, J.R. and Reichert, M. and Bakir, B. and Takano, S. and Kopp, J.L. and Wahl-Feuerstein, A. and Hicks, P. and Sander, M. and Rustgi, A.K.
Developmental Dynamics 247 (6): 854-866. June 2018

Loss of pten and activation of kras synergistically induce formation of intraductal papillary mucinous neoplasia from pancreatic ductal cells in mice.
Kopp, J.L. and Dubois, C.L. and Schaeffer, D.F. and Samani, A. and Taghizadeh, F. and Cowan, R.W. and Rhim, A.D. and Stiles, B.L. and Valasek, M. and Sander, M.
Gastroenterology 154 (5): 1509-1523.e5. April 2018

2017

The 4D nucleome project.
Dekker, J. and Belmont, A.S. and Guttman, M. and Leshyk, V.O. and Lis, J.T. and Lomvardas, S. and Mirny, L.A. and O'Shea, C.C. and Park, P.J. and Ren, B. and Politz, J.C.R. and Shendure, J. and Zhong, S.
Nature 549 (7671): 219-226. 14 September 2017

Interrogating islets in health and disease with single-cell technologies.
Carrano, A.C. and Mulas, F. and Zeng, C. and Sander, M.
Molecular Metabolism 6 (9): 991-1001. September 2017

Pseudotemporal ordering of single cells reveals metabolic control of postnatal ß cell proliferation.
Zeng, C. and Mulas, F. and Sui, Y. and Guan, T. and Miller, N. and Tan, Y. and Liu, F. and Jin, W. and Carrano, A.C. and Huising, M.O. and Shirihai, O.S. and Yeo, G.W. and Sander, M.
Cell Metabolism 25 (5): 1160-1175.e11. 2 May 2017

LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells.
Ediger, B.N. and Lim, H.W. and Juliana, C. and Groff, D.N. and Williams, L.T. and Dominguez, G. and Liu, J.H. and Taylor, B.L. and Walp, E.R. and Kameswaran, V. and Yang, J. and Liu, C. and Hunter, C.S. and Kaestner, K.H. and Naji, A. and Li, C. and Sander, M. and Stein, R. and Sussel, L. and Won, K.J. and May, C.L. and Stoffers, D.A.
Journal of Clinical Investigation 127 (1): 215-229. 3 January 2017

2016

Advances in β cell replacement and regeneration strategies for treating diabetes.
Benthuysen, J.R. and Carrano, A.C. and Sander, M.
Journal of Clinical Investigation 126 (10): 3651-3660. 3 October 2016

Mechanisms of β-cell functional adaptation to changes in workload.
Wortham, M. and Sander, M.
Diabetes Obesity & Metabolism 18 (Suppl 1): 78-86. September 2016

Pancreatic differentiation from human pluripotent stem cells.
Vinckier, N. and Wang, J. and Sander, M.
In: Working with stem cells. Springer, Cham, 257-275. ISBN 978-3-319-30580-6 5 August 2016

Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration.
Barrionuevo, F.J. and Hurtado, A. and Kim, G.J. and Real, F.M. and Bakkali, M. and Kopp, J.L. and Sander, M. and Scherer, G. and Burgos, M. and Jiménez, R.
eLife 5 : e15635. 21 June 2016

Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.
Fox, R.G. and Lytle, N.K. and Jaquish, D.V. and Park, F.D. and Ito, T. and Bajaj, J. and Koechlein, C.S. and Zimdahl, B. and Yano, M. and Kopp, J. and Kritzik, M. and Sicklick, J. and Sander, M. and Grandgenett, P.M. and Hollingsworth, M.A. and Shibata, S. and Pizzo, D. and Valasek, M. and Sasik, R. and Scadeng, M. and Okano, H. and Kim, Y. and MacLeod, A.R. and Lowy, A.M. and Reya, T.
Nature 534 (7607): 407-411. 16 June 2016

High T gives β cells a boost.
Wortham, M. and Sander, M.
Cell Metabolism 23 (5): 761-3. 10 May 2016

Stem cells versus plasticity in liver and pancreas regeneration.
Kopp, J.L. and Grompe, M. and Sander, M.
Nature Cell Biology 18 (3): 238-45. March 2016

ECM signaling regulates collective cellular dynamics to control pancreas branching morphogenesis.
Shih, H.P. and Panlasigui, D. and Cirulli, V. and Sander, M.
Cell Reports 14 (2): 169-79. 12 January 2016

2015

A gene regulatory network cooperatively controlled by Pdx1 and Sox9 governs lineage allocation of foregut progenitor cells.
Shih, H.P. and Seymour, P.A. and Patel, N.A. and Xie, R. and Wang, A. and Liu, P.P. and Yeo, G.W. and Magnuson, M.A. and Sander, M.
Cell Reports 13 (2): 326-36. 13 October 2015

Prdm12 specifies V1 interneurons through cross-repressive interactions with Dbx1 and Nkx6 genes in Xenopus.
Thélie, A. and Desiderio, S. and Hanotel, J. and Quigley, I. and Van Driessche, B. and Rodari, A. and Borromeo, M.D. and Kricha, S. and Lahaye, F. and Croce, J. and Cerda-Moya, G. and Ordoño Fernandez, J. and Bolle, B. and Lewis, K.E. and Sander, M. and Pierani, A. and Schubert, M. and Johnson, J.E. and Kintner, C.R. and Pieler, T. and Van Lint, C. and Henningfeld, K.A. and Bellefroid, E.J. and Van Campenhout, C.
Development 142 (19): 3416-28. 1 October 2015

Hybrid periportal hepatocytes regenerate the injured liver without giving rise to cancer.
Font-Burgada, J. and Shalapour, S. and Ramaswamy, S. and Hsueh, B. and Rossell, D. and Umemura, A. and Taniguchi, K. and Nakagawa, H. and Valasek, M.A. and Ye, L. and Kopp, J.L. and Sander, M. and Carter, H. and Deisseroth, K. and Verma, I.M. and Karin, M.
Cell 162 (4): 766-79. 13 August 2015

Lineage fate of ductular reactions in liver injury and carcinogenesis.
Jörs, S. and Jeliazkova, P. and Ringelhan, M. and Thalhammer, J. and Dürl, S. and Ferrer, J. and Sander, M. and Heikenwalder, M. and Schmid, R.M. and Siveke, J.T. and Geisler, F.
Journal of Clinical Investigation 125 (6): 2445-57. 1 June 2015

Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates.
Wang, A. and Yue, F. and Li, Y. and Xie, R. and Harper, T. and Patel, N.A. and Muth, K. and Palmer, J. and Qiu, Y. and Wang, J. and Lam, D.K. and Raum, J.C. and Stoffers, D.A. and Ren, B. and Sander, M.
Cell Stem Cell 16 (4): 386-99. 2 April 2015

Postnatal β-cell proliferation and mass expansion is dependent on the transcription factor Nkx6.1.
Taylor, B.L. and Benthuysen, J. and Sander, M.
Diabetes 64 (3): 897-903. 1 March 2015

Hnf1b controls pancreas morphogenesis and the generation of Ngn3(+) endocrine progenitors.
De Vas, M.G. and Kopp, J.L. and Heliot, C. and Sander, M. and Cereghini, S. and Haumaitre, C.
Development 142 (5): 871-82. March 2015

A systems view of epigenetic networks regulating pancreas development and β-cell function.
Xie, R. and Carrano, A.C. and Sander, M.
Wiley Interdisciplinary Reviews Systems Biology and Medicine 7 (1): 1-11. 19 February 2015

2014

The role of Sox9 in mouse mammary gland development and maintenance of mammary stem and luminal progenitor cells.
Malhotra, G.K. and Zhao, X. and Edwards, E. and Kopp, J.L. and Naramura, M. and Sander, M. and Band, H. and Band, V.
BMC Developmental Biology 14 : 47. 20 December 2014

Sall1 maintains nephron progenitors and nascent nephrons by acting as both an activator and a repressor.
Kanda, S. and Tanigawa, S. and Ohmori, T. and Taguchi, A. and Kudo, K. and Suzuki, Y. and Sato, Y. and Hino, S. and Sander, M. and Perantoni, A.O. and Sugano, S. and Nakao, M. and Nishinakamura, R.
Journal of the American Society of Nephrology 25 (11): 2584-95. November 2014

Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor.
Zhao, X. and Chen, Y. and Zhu, Q. and Huang, H. and Teng, P. and Zheng, K. and Hu, X. and Xie, B. and Zhang, Z. and Sander, M. and Qiu, M.
PLoS ONE 9 (10): e109171. 6 October 2014

Stem cell epigenetics: looking forward.
Benitah, S.A. and Bracken, A. and Dou, Y. and Huangfu, D. and Ivanova, N. and Koseki, H. and Laurent, L. and Lim, D.A. and Meshorer, E. and Pombo, A. and Sander, M. and Xu, G.L.
Cell Stem Cell 14 (6): 706-709. 5 June 2014

Pancreas development ex vivo: culturing embryonic pancreas explants on permeable culture inserts, with fibronectin-coated glass microwells, or embedded in three-dimensional Matrigel(TM).
Shih, H.P. and Sander, M.
Methods in Molecular Biology 1210 : 229-37. 1 January 2014

New insights into the cell lineage of pancreatic ductal adenocarcinoma: evidence for tumor stem cells in premalignant lesions?
Kopp, J.L. and Sander, M.
Gastroenterology 146 (1): 24-6. January 2014

2013

Sox9 plays multiple roles in the lung epithelium during branching morphogenesis.
Rockich, B.E. and Hrycaj, S.M. and Shih, H.P. and Nagy, M.S. and Ferguson, M.A.H. and Kopp, J.L. and Sander, M. and Wellik, D.M. and Spence, J.R.
Proceedings of the National Academy of Sciences of the United States of America 110 (47): E4456-64. 19 November 2013

Pancreas organogenesis: from lineage determination to morphogenesis.
Shih, H.P. and Wang, A. and Sander, M.
Annual Review of Cell and Developmental Biology 29 : 81-105. October 2013

Nkx6.1 is essential for maintaining the functional state of pancreatic beta cells.
Taylor, B.L. and Liu, F.F. and Sander, M.
Cell Reports 4 (6): 1262-75. 26 September 2013

Inactivation of specific β cell transcription factors in type 2 diabetes.
Guo, S. and Dai, C. and Guo, M. and Taylor, B. and Harmon, J.S. and Sander, M. and Robertson, R.P. and Powers, A.C. and Stein, R.
Journal of Clinical Investigation 123 (8): 3305-16. August 2013

Colony-forming cells in the adult mouse pancreas are expandable in Matrigel and form endocrine/acinar colonies in laminin hydrogel.
Jin, L. and Feng, T. and Shih, H.P. and Zerda, R. and Luo, A. and Hsu, J. and Mahdavi, A. and Sander, M. and Tirrell, D.A. and Riggs, A.D. and Ku, H.T.
Proceedings of the National Academy of Sciences of the United States of America 110 (10): 3907-12. 5 March 2013

Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells.
Xie, R. and Everett, L.J. and Lim, H.W. and Patel, N.A. and Schug, J. and Kroon, E. and Kelly, O.G. and Wang, A. and D'Amour, K.A. and Robins, A.J. and Won, K.J. and Kaestner, K.H. and Sander, M.
Cell Stem Cell 12 (2): 224-37. 7 February 2013

Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.
Schaffer, A.E. and Taylor, B.L. and Benthuysen, J.R. and Liu, J. and Thorel, F. and Yuan, W. and Jiao, Y. and Kaestner, K.H. and Herrera, P.L. and Magnuson, M.A. and May, C.L. and Sander, M.
PLoS Genetics 9 (1): e1003274. 31 January 2013

2012

Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells.
van der Meulen, T. and Xie, R. and Kelly, O.G. and Vale, W.W. and Sander, M. and Huising, M.O.
PLoS ONE 7 (12): e52181. 14 December 2012

Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma.
Kopp, J.L. and von Figura, G. and Mayes, E. and Liu, F.F. and Dubois, C.L. and Morris, J.P. and Pan, F.C. and Akiyama, H. and Wright, C.V.E. and Jensen, K. and Hebrok, M. and Sander, M.
Cancer Cell 22 (6): 737-50. 11 December 2012

Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes.
Morán, I. and Akerman, I. and van de Bunt, M. and Xie, R. and Benazra, M. and Nammo, T. and Arnes, L. and Nakić, N. and García-Hurtado, J. and Rodríguez-Seguí, S. and Pasquali, L. and Sauty-Colace, C. and Beucher, A. and Scharfmann, R. and van Arensbergen, J. and Johnson, P.R. and Berry, A. and Lee, C. and Harkins, T. and Gmyr, V. and Pattou, F. and Kerr-Conte, J. and Piemonti, L. and Berney, T. and Hanley, N. and Gloyn, A.L. and Sussel, L. and Langman, L. and Brayman, K.L. and Sander, M. and McCarthy, M.I. and Ravassard, P. and Ferrer, J.
Cell Metabolism 16 (4): 435-48. 3 October 2012

A Sox9/Fgf feed-forward loop maintains pancreatic organ identity.
Seymour, P.A. and Shih, H.P. and Patel, N.A. and Freude, K.K. and Xie, R. and Lim, C.J. and Sander, M.
Development 139 (18): 3363-72. September 2012

A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation.
Shih, H.P. and Kopp, J.L. and Sandhu, M. and Dubois, C.L. and Seymour, P.A. and Grapin-Botton, A. and Sander, M.
Development 139 (14): 2488-99. July 2012

Generating cells of the gastrointestinal system: current approaches and applications for the differentiation of human pluripotent stem cells.
Wang, A. and Sander, M.
Journal of Molecular Medicine 90 (7): 763-71. July 2012

2011

Transgenic overexpression of the transcription factor Nkx6.1 in β-cells of mice does not increase β-cell proliferation, β-cell mass, or improve glucose clearance.
Schaffer, A.E. and Yang, A.J. and Thorel, F. and Herrera, P.L. and Sander, M.
Molecular Endocrinology 25 (11): 1904-14. 1 November 2011

Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells.
Carpentier, R. and Suñer, R.E. and van Hul, N. and Kopp, J.L. and Beaudry, J.B. and Cordi, S. and Antoniou, A. and Raynaud, P. and Lepreux, S. and Jacquemin, P. and Leclercq, I.A. and Sander, M. and Lemaigre, F.P.
Gastroenterology 141 (4): 1432-8, 1438.e1-4. October 2011

Sox9-haploinsufficiency causes glucose intolerance in mice.
Dubois, C.L. and Shih, H.P. and Seymour, P.A. and Patel, N.A. and Behrmann, J.M. and Ngo, V. and Sander, M.
PLoS ONE 6 (8): e23131. 2 August 2011

Progenitor cell domains in the developing and adult pancreas.
Kopp, J.L. and Dubois, C.L. and Hao, E. and Thorel, F. and Herrera, P.L. and Sander, M.
Cell Cycle 10 (12): 1921-7. 15 June 2011

Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice.
Dorrell, C. and Erker, L. and Schug, J. and Kopp, J.L. and Canaday, P.S. and Fox, A.J. and Smirnova, O. and Duncan, A.W. and Finegold, M.J. and Sander, M. and Kaestner, K.H. and Grompe, M.
Genes & Development 25 (11): 1193-203. 1 June 2011

Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell development.
Seymour, P.A. and Sander, M.
Diabetes 60 (2): 364-76. 1 February 2011

Sox9(+) ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas.
Kopp, J.L. and Dubois, C.L. and Schaffer, A.E. and Hao, E. and Shih, H.P. and Seymour, P.A. and Ma, J. and Sander, M.
Development 138 (4): 653-65. February 2011

2010

Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors.
Schaffer, A.E. and Freude, K.K. and Nelson, S.B. and Sander, M.
Developmental Cell 18 (6): 1022-9. 15 June 2010

2009

Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain.
Prakash, N. and Puelles, E. and Freude, K. and Trümbach, D. and Omodei, D. and Di Salvio, M. and Sussel, L. and Ericson, J. and Sander, M. and Simeone, A. and Wurst, W.
Development 136 (15): 2545-55. August 2009

Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function.
Wang, S. and Jensen, J.N. and Seymour, P.A. and Hsu, W. and Dor, Y. and Sander, M. and Magnuson, M.A. and Serup, P. and Gu, G.
Proceedings of the National Academy of Sciences of the United States of America 106 (24): 9715-20. 16 June 2009

2008

A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation.
Seymour, P.A. and Freude, K.K. and Dubois, C.L. and Shih, H.P. and Patel, N.A. and Sander, M.
Developmental Biology 323 (1): 19-30. 1 November 2008

Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation.
Jonckheere, N. and Mayes, E. and Shih, H.P. and Li, B. and Lioubinski, O. and Dai, X. and Sander, M.
Developmental Biology 318 (2): 224-35. 15 June 2008

2007

Immunohistochemical detection of beta-galactosidase or green fluorescent protein on tissue sections.
Seymour, P.A. and Sander, M.
Methods in Molecular Biology 411 : 13-23. 13 September 2007

The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells.
Nelson, S.B. and Schaffer, A.E. and Sander, M.
Development 134 (13): 2491-500. July 2007

SOX9 is required for maintenance of the pancreatic progenitor cell pool.
Seymour, P.A. and Freude, K.K. and Tran, M.N. and Mayes, E.E. and Jensen, J. and Kist, R. and Scherer, G. and Sander, M.
Proceedings of the National Academy of Sciences of the United States of America 104 (6): 1865-70. 6 February 2007

2005

Endodermal expression of Nkx6 genes depends differentially on Pdx1.
Pedersen, J.K. and Nelson, S.B. and Jorgensen, M.C. and Henseleit, K.D. and Fujitani, Y. and Wright, C.V.E. and Sander, M. and Serup, P.
Developmental Biology 288 (2): 487-501. 15 December 2005

NKX6 transcription factor activity is required for (α)- and (β)-cell development in the pancreas.
Henseleit, K.D. and Nelson, S.B. and Kuhlbrodt, K. and Hennings, J.C. and Ericson, J. and Sander, M.
Development 132 (13): 3139-49. July 2005

Expression of Nkx6 genes in the hindbrain and gut of the developing mouse.
Nelson, S.B. and Janiesch, C. and Sander, M.
Journal of Histochemistry and Cytochemistry 53 (6): 787-90. June 2005

Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling.
Cai, J. and Qi, Y. and Hu, X. and Tan, M. and Liu, Z. and Zhang, J. and Li, Q. and Sander, M. and Qiu, M.
Neuron 45 (1): 41-53. 6 January 2005

2004

Pancreatic islet progenitor cells in neurogenin 3-yellow fluorescent protein knock-add-on mice.
Mellitzer, G. and Martín, M. and Sidhoum-Jenny, M. and Orvain, C. and Barths, J. and Seymour, P.A. and Sander, M. and Gradwohl, G.
Molecular Endocrinology 18 (11): 2765-76. 1 November 2004

The MafA transcription factor appears to be responsible for tissue-specific expression of insulin.
Matsuoka, T. and Artner, I. and Henderson, E. and Means, A. and Sander, M. and Stein, R.
Proceedings of the National Academy of Sciences of the United States of America 101 (9): 2930-3. 2 March 2004

2003

Nkx6.1 controls migration and axon pathfinding of cranial branchio-motoneurons.
Müller, M. and Jabs, N. and Lorke, D.E. and Fritzsch, B. and Sander, M.
Development 130 (23): 5815-26. December 2003

Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 homeodomain transcription factor.
Liu, R. and Cai, J. and Hu, X. and Tan, M. and Qi, Y. and German, M. and Rubenstein, J. and Sander, M. and Qiu, M.
Development 130 (25): 6221-31. December 2003

Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain.
Pattyn, A. and Vallstedt, A. and Dias, J.M. and Sander, M. and Ericson, J.
Development 130 (17): 4149-59. September 2003

Expression of Sox transcription factors in the developing mouse pancreas.
Lioubinski, O. and Müller, M. and Wegner, M. and Sander, M.
Developmental Dynamics 227 (3): 402-8. July 2003

2001

Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification.
Vallstedt, A. and Muhr, J. and Pattyn, A. and Pierani, A. and Mendelsohn, M. and Sander, M. and Jessell, T.M. and Ericson, J.
Neuron 31 (5): 743-55. 13 September 2001

2000

Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.
Sander, M. and Sussel, L. and Conners, J. and Scheel, D. and Kalamaras, J. and Dela Cruz, F. and Schwitzgebel, V. and Hayes-Jordan, A. and German, M.
Development 127 (24): 5533-40. December 2000

Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates.
Sander, M. and Paydar, S. and Ericson, J. and Briscoe, J. and Berber, E. and German, M. and Jessell, T.M. and Rubenstein, J.L.
Genes and Development 14 (17): 2134-9. 1 September 2000

1998

A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured islets.
Sander, M. and Griffen, S.C. and Huang, J. and German, M.S.
Proceedings of the National Academy of Sciences of the United States of America 95 (20): 11572-7. 29 September 1998

1997

Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.
Sander, M. and Neubüser, A. and Kalamaras, J. and Ee, H.C. and Martin, G.R. and German, M.S.
Genes and Development 11 (13): 1662-73. 1 July 1997

The beta cell transcription factors and development of the pancreas.
Sander, M. and German, M.S.
Journal of Molecular Medicine 75 (5): 327-40. April 1997

1995

Chronic dexamethasone treatment suppresses hypertension development in the transgenic rat TGR(mREN2)27.
Djavidani, B. and Sander, M. and Kreutz, R. and Zeh, K. and Bader, M. and Mellon, S.H. and Vecsei, P. and Peters, J. and Ganten, D.
Journal of Hypertension 13 (6): 637-645. 1 January 1995

Rodent models for studying steroids and hypertension : from fetal development to cells in culture.
Mellon, S.H. and Compagnone, N. and Sander, M. and Cover, C. and Ganten, D. and Djavidani, B.
Steroids 60 (1): 59-64. 1 January 1995

1994

Role of adrenal renin in the regulation of adrenal steroidogenesis corticotropin.
Sander, M. and Ganten, D. and Mellon, S.H.
Proceedings of the National Academy of Sciences of the United States of America 91 (1): 148-152. 4 January 1994

1993

Regulation adrenaler Aldosteronsekretion und adrenalen Renins in TGR(mREN2)27.
Peters, J. and Djavidani, B. and Sander, M. and Bader, M. and Ganten, D.
Nieren- und Hochdruckkrankheiten 22 : 364-368. 1 January 1993

Renin gene expression and hypertension in transgenic animals.
Bader, M. and Lee, M.A. and Zhao, Y. and Boehm, M. and Bachmann, J. and Sander, M. and Djavidani, B. and Bachmann, S. and Zimmermann, F. and Wilbertz, J. and Zeh, K. and Wagner, J. and Peters, J. and Ganten, D.
In: Cellular and Molecular Biology of the Renin-Angiotensin System. CRC Press, Boca Raton, 60-93. 1 January 1993

1992

The role of the adrenal gland in hypertensive transgenic rat TGR(mREN2)27.
Sander, M. and Bader, M. and Djavidani, B. and Masergluth, C. and Vecsei, P. and Mullins, J.J. and Ganten, D. and Peters, J.
Endocrinology 131 (2): 807-814. 1 August 1992

Role of tissue renin in the pathophysiology of hypertension in TGR(mREN2)27 rats.
Bader, M. and Zhao, Y. and Sander, M. and Lee, M.A. and Bachmann, J. and Boehm, M. and Djavidani, B. and Peters, J. and Mullins, J.J. and Ganten, D.
Hypertension 19 (6 Pt 2): 681-686. 1 June 1992

Gesteigerte Aldosteronbiosynthese in TGR(mREN2)27: Funktionelle Bedeutung eines lokalen intraadrenalen Renin-Angiotensin-Systems.
Peters, J. and Djavidani, B. and Muenter, K. and Bader, M. and Sander, M. and Mullins, J.J. and Ganten, D.
Nieren- und Hochdruckkrankheiten 21 : 545-546. 1 January 1992

The role of adrenal renin in steroid metabolism and development of hypertension in transgenic rats TGR(Messenger REN2).
Peters, J. and Sander, M. and Munter, K. and Lee, M.A. and Djavidani, B. and Bader, M. and Maser-Gluth, C. and Vecsei, P. and Ganten, D. and Mullins, J.J.
In: Genetic Hypertension : 7th International Symposium on Spontaneously Hypertensive Rats (Colloque Inserm ; 218). John Libbey Eurotext, Paris, 345-347. 1 January 1992

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