2026

Unraveling the single-cell spatial landscapes of melanoma brain metastases.
Manukyan, Artür ORCID: https://orcid.org/0000-0002-0441-9517, Peters, Kristin, Radbruch, Helena ORCID: https://orcid.org/0000-0001-6941-3397, Fusco, Federico, Geserick, Felicitas, Rossner, Florian, Lehmann, Annika, Kleo, Karsten ORCID: https://orcid.org/0000-0001-9136-6902, Conrad, Thomas ORCID: https://orcid.org/0000-0001-5618-6295, Altmüller, Janine ORCID: https://orcid.org/0000-0003-4372-1521, Plumbom, Izabela ORCID: https://orcid.org/0009-0006-3720-3700, Akalin, Altuna ORCID: https://orcid.org/0000-0002-0468-0117, Jürchott, Karsten, Wyler, Emanuel ORCID: https://orcid.org/0000-0002-9884-1806, Landthaler, Markus ORCID: https://orcid.org/0000-0002-1075-8734, Delbridge, Claire, Sendler, Matthias, Radke, Josefine ORCID: https://orcid.org/0000-0001-9860-2007 and Redmer, Torben ORCID: https://orcid.org/0000-0002-0050-9478
medRxiv : 2025.08.29.25334740v3. 3 June 2026

Distinct roles for MNK1 and MNK2 in social and cognitive behavior through kinase-specific regulation of the synaptic proteome and phosphoproteome.
Proce, Rosalba Olga, Steinecker, Maria, Giacomelli, Chiara ORCID: https://orcid.org/0000-0003-1466-1371, Uddström, Erika ORCID: https://orcid.org/0009-0009-5298-480X, Chatterjee, Anirban ORCID: https://orcid.org/0009-0002-8271-384X, Wüsthoff, Souhaila ORCID: https://orcid.org/0000-0001-7653-3565, Teixeira Alves, Luiz Gustavo ORCID: https://orcid.org/0000-0002-5822-4168, Popp, Oliver ORCID: https://orcid.org/0000-0001-6240-4666, Pohl, Tobias ORCID: https://orcid.org/0000-0001-8698-8475, Maxwell, Katie, Hortmann, Lucie, Kunz, Severine ORCID: https://orcid.org/0000-0002-0131-3506, Mertins, Philipp ORCID: https://orcid.org/0000-0002-2245-528X, Landthaler, Markus ORCID: https://orcid.org/0000-0002-1075-8734, Bunina, Daria ORCID: https://orcid.org/0000-0002-5885-7440 and Hörnberg, Hanna ORCID: https://orcid.org/0000-0001-9142-1932
Molecular Psychiatry 31 (6): 3446-3461. June 2026

Spatial and phenotypic heterogeneity of ILC subsets in mouse lung under type 2 inflammatory conditions.
Kroh, Sandy ORCID: https://orcid.org/0000-0002-3736-3361, Pascual-Reguant, Anna ORCID: https://orcid.org/0000-0002-5042-3699, Manukyan, Artür ORCID: https://orcid.org/0000-0002-0441-9517, Uecker, Ralf, Günther, Robert, Philipsen, Lars ORCID: https://orcid.org/0000-0001-5112-495X, Koehler, Ralf ORCID: https://orcid.org/0000-0002-3660-1196, Mex, Peggy ORCID: https://orcid.org/0009-0005-7567-1313, Landthaler, Markus ORCID: https://orcid.org/0000-0002-1075-8734, Niesner, Raluca A. ORCID: https://orcid.org/0000-0001-8969-5432 and Hauser, Anja E. ORCID: https://orcid.org/0000-0002-7725-9526
European Journal of Immunology 56 (6): e70223. June 2026

Global quantification of mammalian gene expression noise.
Welter, Anna Sophie ORCID: https://orcid.org/0009-0003-9846-3889, Mutschler, Florian ORCID: https://orcid.org/0009-0002-0992-7171, Simon, Mareike ORCID: https://orcid.org/0000-0001-7213-9499, Giacomelli, Chiara ORCID: https://orcid.org/0000-0003-1466-1371, Branscheid, Ann-Christin, Manukyan, Artur ORCID: https://orcid.org/0000-0002-0441-9517, Teixeira Alves, Luiz Gustavo ORCID: https://orcid.org/0000-0002-5822-4168, Gerwien, Maximilian ORCID: https://orcid.org/0000-0002-2884-4155, Kerridge, Robert, Landthaler, Markus ORCID: https://orcid.org/0000-0002-1075-8734, Wolf, Jana ORCID: https://orcid.org/0000-0003-3254-5868 and Selbach, Matthias ORCID: https://orcid.org/0000-0003-2454-8751
bioRxiv : 2026.05.11.724258. 14 May 2026

Processed data and code for Manuscript: Global quantification of mammalian gene expression noise.
Welter, Anna Sopie ORCID: https://orcid.org/0009-0003-9846-3889, Mutschler, Florian ORCID: https://orcid.org/0009-0002-0992-7171, Simon, Mareike ORCID: https://orcid.org/0000-0001-7213-9499, Giacomelli, Chiara ORCID: https://orcid.org/0000-0003-1466-1371, Branscheid, Ann-Christin, Manukyan, Artur ORCID: https://orcid.org/0000-0002-0441-9517, Teixeira Alves, Luiz Gustavo ORCID: https://orcid.org/0000-0002-5822-4168, Gerwien, Maximilian ORCID: https://orcid.org/0000-0002-2884-4155, Kerridge, Robert, Landthaler, Markus ORCID: https://orcid.org/0000-0002-1075-8734, Wolf, Jana ORCID: https://orcid.org/0000-0003-3254-5868 and Selbach, Matthias ORCID: https://orcid.org/0000-0003-2454-8751
[Dataset] 14 May 2026

Clade 2.3.4.4b H5N1 influenza A virus exhibits high infectivity in human respiratory tract models.
Löwa, Anna, Budt, Matthias, Balázs, Anita, Sikora, Victor, Melzer, Mark, Rubil, Tihomir, Pfeiffer, Annika E., Fischer, Mara, Mieth, Maren, Hellwig, Katharina, Wyler, Emanuel ORCID: https://orcid.org/0000-0002-9884-1806, Diel, Diego G., Tönnies, Mario, Bauer, Torsten T., Graff, Mareike, Neudecker, Jens, Rückert, Jens-C., Mall, Marcus A., Gruber, Achim D., Landthaler, Markus ORCID: https://orcid.org/0000-0002-1075-8734, Buchauer, Lisa, Hippenstiel, Stefan, Wolff, Thorsten and Hocke, Andreas C.
Journal of Infection 92 (5): 106722. May 2026

Immune–proteo–metabolomic changes link to Aβ and tau pathology in Alzheimer disease.
Wang, Meng, Buthut, Maria, Meinhardt, Jenny, Otto, Carolin, Gallaccio, Gerardina ORCID: https://orcid.org/0000-0002-1060-5244, Fernández-Zapata, Camila ORCID: https://orcid.org/0000-0003-4795-6053, Teves, Matteo, Samol, Claudia, Dettmer, Katja, Heckscher, Simon, Kamboj, Sakshi, Bahar, Yozlem, Conrad, Christian, Böttcher, Christian, Kunkel, Desiree, Ruprecht, Klemens, Paul, Friedemann ORCID: https://orcid.org/0000-0002-6378-0070, Oefner, Peter J., Radbruch, Helena ORCID: https://orcid.org/0000-0001-6941-3397, Gronwald, Wolfram, Prüß, Harald and Böttcher, Chotima ORCID: https://orcid.org/0000-0002-6226-586X
Alzheimer's & Dementia 22 (4): e71359. April 2026

Resource data for: Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome.
Boehm, Volker ORCID: https://orcid.org/0000-0001-7588-9842, Wallmeroth, Damaris ORCID: https://orcid.org/0000-0003-3437-4070, Wulf, Paul ORCID: https://orcid.org/0009-0002-6356-2361, Popp, Oliver ORCID: https://orcid.org/0000-0001-6240-4666, Teixeira Alves, Luiz Gustavo ORCID: https://orcid.org/0000-0002-5822-4168, Reinecke, Lucie ORCID: https://orcid.org/0009-0003-7083-0923, Riedel, Maximilian ORCID: https://orcid.org/0009-0002-9817-3083, Wyler, Emanuel ORCID: https://orcid.org/0000-0002-9884-1806, Franitza, Marek, Becker, Kerstin ORCID: https://orcid.org/0009-0009-7897-7181, Polkovnychenko, Karina, Del Giudice, Simone ORCID: https://orcid.org/0000-0003-0194-3767, Benlasfer, Nouhad, Mertins, Philipp ORCID: https://orcid.org/0000-0002-2245-528X, Landthaler, Markus ORCID: https://orcid.org/0000-0002-1075-8734 and Gehring, Niels H. ORCID: https://orcid.org/0000-0001-7792-1164
[Dataset] 18 March 2026

Altered cholesterol immunometabolism activates the macrophage NLRP3-inflammasome in lung fibrosis.
Vaso, Mariza, Dukic, Matija, Pennitz, Peter, Manukyan, Artür ORCID: https://orcid.org/0000-0002-0441-9517, Collum, Scott, Lin, Wanchang, Winder, Catherine L, Dunn, Warwick B, Schupp, Jonas C., Braubach, Peter, Wygrecka, Malgorzata, Ren, Dewei, Suarez, Erik E, Huang, Howard J, Hussain, Rahat, Patel, Bela, Karmouty-Quintana, Harry, Akalin, Altuna ORCID: https://orcid.org/0000-0002-0468-0117, Landthaler, Markus ORCID: https://orcid.org/0000-0002-1075-8734, Nouailles, Geraldine, Ochs, Matthias, Lopez-Rodriguez, Elena and Giambelluca, Sonia
American Journal of Respiratory Cell and Molecular Biology 21 February 2026 (In Press)

Complex human hear bearing skin organoids reveal cell type specific susceptibility and innate immune responses to Herpes Simplex Virus 1.
Wyler, Emanuel ORCID: https://orcid.org/0000-0002-9884-1806, Albertini, Silvia ORCID: https://orcid.org/0000-0002-8540-5378, Friedel, Caroline C. ORCID: https://orcid.org/0000-0003-3569-4877, Manukyan, Artür ORCID: https://orcid.org/0000-0002-0441-9517, Winterfeldt, Annalena, Bracker, Nina, Huang, Jiabin ORCID: https://orcid.org/0000-0002-3480-7115, Krasemann, Susanne ORCID: https://orcid.org/0000-0001-8795-818X, Plumbon, Izabela ORCID: https://orcid.org/0009-0006-3720-3700, Altmüller, Janine ORCID: https://orcid.org/0000-0003-4372-1521, Conrad, Thomas ORCID: https://orcid.org/0000-0001-5618-6295, Reimer, Rudolph, Schneider, Carola, Radbruch, Helena ORCID: https://orcid.org/0000-0001-6941-3397, Hafezi, Wali, Hansen, Arne, Grundhoff, Adam ORCID: https://orcid.org/0000-0003-0940-7045, Landthaler, Markus ORCID: https://orcid.org/0000-0002-1075-8734, Fischer, Nicole ORCID: https://orcid.org/0000-0002-5092-8179 and Czech-Sioli, Manja ORCID: https://orcid.org/0000-0002-7720-3282
bioRxiv : 2025.02.10.637415v2. 12 January 2026

2025

The deubiquitinase OTUD7B ameliorates central nervous system autoimmunity by inhibiting degradation of glial fibrillary acidic protein and astrocyte hyperinflammation.
Harit, K., Yi, W., Jeron, A., Schmidt, J., Beckervordersandfort-Bonk, R., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Plumbon, I., Manukyan, A. ORCID: https://orcid.org/0000-0002-0441-9517, Deckert, M., Conrad, T. ORCID: https://orcid.org/0000-0001-5618-6295, Altmüller, J. ORCID: https://orcid.org/0000-0003-4372-1521, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Radbruch, H. ORCID: https://orcid.org/0000-0001-6941-3397, Wang, X., Nishanth, G. and Schlüter, D.
[Dataset] 1 December 2025

Altered cholesterol immunometabolism activates the macrophage NLRP3-inflammasome in lung fibrosis.
Giambelluca, Sonia, Pennitz, Peter and Manukyan, Artür ORCID: https://orcid.org/0000-0002-0441-9517
[Dataset] 21 November 2025

Astrocytic-OTUD7B ameliorates murine experimental autoimmune encephalomyelitis by stabilizing glial fibrillary acidic protein and preventing inflammation.
Harit, Kunjan, Yi, Wenjing, Jeron, Andreas, Schmidt, Jakob, Beckervordersandforth, Ruth ORCID: https://orcid.org/0000-0002-3617-7567, Wyler, Emanuel ORCID: https://orcid.org/0000-0002-9884-1806, Manukyan, Artür ORCID: https://orcid.org/0000-0002-0441-9517, Deckert, Martina, Radbruch, Helena ORCID: https://orcid.org/0000-0001-6941-3397, Conrad, Thomas ORCID: https://orcid.org/0000-0001-5618-6295, Altmüller, Janine ORCID: https://orcid.org/0000-0003-4372-1521, Landthaler, Markus ORCID: https://orcid.org/0000-0002-1075-8734, Wang, Xu ORCID: https://orcid.org/0000-0001-8428-9339, Nishanth, Gopala ORCID: https://orcid.org/0000-0002-7280-5663 and Schlüter, Dirk ORCID: https://orcid.org/0000-0003-1478-3328
Nature Communications 16 (1): 9279. 20 October 2025

Sensitive dissection of a genomic regulatory landscape using bulk and targeted single-cell activation.
Vučićević, Dubravka ORCID: https://orcid.org/0000-0002-1162-6709, Hsu, Che-Wei ORCID: https://orcid.org/0000-0003-3709-9748, Lopez Zepeda, Lorena Sofia ORCID: https://orcid.org/0000-0001-9764-0984, Burkert, Martin ORCID: https://orcid.org/0000-0002-6721-9985, Hirsekorn, Antje, Bilić, Ilija ORCID: https://orcid.org/0000-0002-2730-1634, Kastelić, Nicolai, Landthaler, Markus ORCID: https://orcid.org/0000-0002-1075-8734, Lacadie, Scott Allen ORCID: https://orcid.org/0000-0002-0893-5340 and Ohler, Uwe ORCID: https://orcid.org/0000-0002-0881-3116
Cell Genomics 5 (10): 100984. 8 October 2025

Rapid glycoprotein evolution enables variant interactions in herpes simplex virus type 1.
Höfler, Thomas ORCID: https://orcid.org/0000-0001-7486-5582, Zeitlow, Michaela, Kim, Ji Y., Wyler, Emanuel ORCID: https://orcid.org/0000-0002-9884-1806 and Trimpert, Jakob ORCID: https://orcid.org/0000-0003-1616-0810
Virus Evolution 11 (1): veaf072. 6 October 2025

Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome.
Boehm, Volker, Wallmeroth, Damaris, Wulf, Paul O. ORCID: https://orcid.org/0009-0002-6356-2361, Popp, Oliver ORCID: https://orcid.org/0000-0001-6240-4666, Teixeira Alves, Luiz Gustavo ORCID: https://orcid.org/0000-0002-5822-4168, Reinecke, Lucie ORCID: https://orcid.org/0009-0003-7083-0923, Riedel, Maximilian ORCID: https://orcid.org/0009-0002-9817-3083, Wyler, Emanuel ORCID: https://orcid.org/0000-0002-9884-1806, Franitza, Marek, Becker, Kerstin, Polkovnychenko, Karina, Del Giudice, Simone ORCID: https://orcid.org/0000-0003-0194-3767, Benlasfer, Nouhad, Mertins, Philipp ORCID: https://orcid.org/0000-0002-2245-528X, Landthaler, Markus ORCID: https://orcid.org/0000-0002-1075-8734 and Gehring, Niels H.
Molecular Cell 85 (18): 3524-3546.e12. 18 September 2025

Sensitive dissection of a genomic regulatory landscape using bulk and targeted single-cell activation [ATAC-seq].
Vučićević, D. ORCID: https://orcid.org/0000-0002-1162-6709, Hsu, C.W. ORCID: https://orcid.org/0000-0003-3709-9748, Lopez Zepeda, L.S. ORCID: https://orcid.org/0000-0001-9764-0984, Burkert, M. ORCID: https://orcid.org/0000-0002-6721-9985, Hirsekorn, A., Bilić, I. ORCID: https://orcid.org/0000-0002-2730-1634, Kastelić, N., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Lacadie, S.A. ORCID: https://orcid.org/0000-0002-0893-5340 and Ohler, U. ORCID: https://orcid.org/0000-0002-0881-3116
[Dataset] 11 September 2025

Sensitive dissection of a genomic regulatory landscape using bulk and targeted single-cell activation [Chromatin RNA-seq].
Vučićević, Dubravka ORCID: https://orcid.org/0000-0002-1162-6709, Hsu, C.W. ORCID: https://orcid.org/0000-0003-3709-9748, Lopez-Zepeda, L.S. ORCID: https://orcid.org/0000-0001-9764-0984, Burkert, M. ORCID: https://orcid.org/0000-0002-6721-9985, Hirsekorn, A., Bilić, I. ORCID: https://orcid.org/0000-0002-2730-1634, Kastelić, N., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Lacadie, S.A. ORCID: https://orcid.org/0000-0002-0893-5340 and Ohler, U. ORCID: https://orcid.org/0000-0002-0881-3116
[Dataset] 11 September 2025

Sensitive dissection of a genomic regulatory landscape using bulk and targeted single-cell activation [TESLA-seq].
Vučićević, Dubravka ORCID: https://orcid.org/0000-0002-1162-6709, Hsu, C.W. ORCID: https://orcid.org/0000-0003-3709-9748, Lopez Zepeda, L.S. ORCID: https://orcid.org/0000-0001-9764-0984, Burkert, M. ORCID: https://orcid.org/0000-0002-6721-9985, Hirsekorn, A., Bilić, I. ORCID: https://orcid.org/0000-0002-2730-1634, Kastelić, N., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Lacadie, S.A. ORCID: https://orcid.org/0000-0002-0893-5340 and Ohler, U. ORCID: https://orcid.org/0000-0002-0881-3116
[Dataset] 11 September 2025

Sensitive dissection of a genomic regulatory landscape using bulk and targeted single-cell activation [bulkCRISPR-screen].
Vučićević, D. ORCID: https://orcid.org/0000-0002-1162-6709, Hsu, C.W. ORCID: https://orcid.org/0000-0003-3709-9748, Lopez Zepeda, L.S. ORCID: https://orcid.org/0000-0001-9764-0984, Burkert, M. ORCID: https://orcid.org/0000-0002-6721-9985, Hirsekorn, A., Bilić, I. ORCID: https://orcid.org/0000-0002-2730-1634, Kastelić, N., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Lacadie, S.A. ORCID: https://orcid.org/0000-0002-0893-5340 and Ohler, U. ORCID: https://orcid.org/0000-0002-0881-3116
[Dataset] 11 September 2025

Initial Test-RNA-Seq of UPF1 depletion in human colorectal adenocarcinoma cell line HCT116 via the auxin-inducible degron (AID) system.
Böhm, Volker and Landthaler, Markus ORCID: https://orcid.org/0000-0002-1075-8734
[Dataset] 1 September 2025

Long-read ONT-dRNA and PacBio Kinnex full-length RNA sequencing of UPF1 depletion in human colorectal adenocarcinoma cell line HCT116 via the auxin-inducible degron (AID) system.
Böhm, Volker and Landthaler, Markus ORCID: https://orcid.org/0000-0002-1075-8734
[Dataset] 1 September 2025

RNA-Seq of SMG1 inhibition via SMG1i in human foreskin fibroblast (HFF) and human umbilical vein endothelial cells (HUVEC).
Böhm, Volker and Landthaler, Markus ORCID: https://orcid.org/0000-0002-1075-8734
[Dataset] 1 September 2025

Ribo-Seq of UPF1 depletion in human colorectal adenocarcinoma cell line HCT116 via the auxin-inducible degron (AID) system.
Böhm, Volker and Landthaler, Markus ORCID: https://orcid.org/0000-0002-1075-8734
[Dataset] 1 September 2025

SLAM-Seq of UPF1 depletion in human colorectal adenocarcinoma cell line HCT116 via the auxin-inducible degron (AID) system.
Böhm, Volker and Landthaler, Markus ORCID: https://orcid.org/0000-0002-1075-8734
[Dataset] 1 September 2025

Dataset: rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome.
Boehm, Volker ORCID: https://orcid.org/0000-0001-7588-9842, Wallmeroth, Damaris ORCID: https://orcid.org/0000-0003-3437-4070, Wulf, Paul O. ORCID: https://orcid.org/0009-0002-6356-2361, Popp, Oliver ORCID: https://orcid.org/0000-0001-6240-4666, Teixeira Alves, Luiz Gustavo ORCID: https://orcid.org/0000-0002-5822-4168, Reinecke, Lucie ORCID: https://orcid.org/0009-0003-7083-0923, Riedel, Maximilian ORCID: https://orcid.org/0009-0002-9817-3083, Wyler, Emanuel ORCID: https://orcid.org/0000-0002-9884-1806, Franitza, Marek, Becker, Kerstin ORCID: https://orcid.org/0009-0009-7897-7181, Polkovnychenko, Karina ORCID: https://orcid.org/0009-0001-9468-3150, Del Giudice, Simone ORCID: https://orcid.org/0000-0003-0194-3767, Benlasfer, Nouhad, Mertins, Philipp ORCID: https://orcid.org/0000-0002-2245-528X, Landthaler, Markus ORCID: https://orcid.org/0000-0002-1075-8734 and Gehring, Niels H.
[Dataset] 31 August 2025

Rewired type I IFN signaling is linked to age-dependent differences in COVID-19.
Petrov, Lev, Brumhard, Sophia, Wisniewski, Sebastian, Georg, Philipp, Hillus, David, Hiller, Anna, Astaburuaga-García, Rosario, Blüthgen, Nils, Wyler, Emanuel ORCID: https://orcid.org/0000-0002-9884-1806, Vogt, Katrin, Dey, Hannah-Philine, von Stillfried, Saskia, Iwert, Christina, Bülow, Roman D., Märkl, Bruno, Maas, Lukas, Langner, Christine, Meyer, Tim, Loske, Jennifer, Eils, Roland, Lehmann, Irina, Ondruschka, Benjamin, Ralser, Markus, Trimpert, Jakob, Boor, Peter, Bedoui, Sammy, Meisel, Christian, Mall, Marcus A., Corman, Victor M., Sander, Leif Erik, Röhmel, Jobst and Sawitzki, Birgit
Cell Reports Medicine 6 (8): 102285. 19 August 2025

The establishment of cell-type specific gene regulation in the sea urchin embryo.
Brandenburg, Jonas Maurice, Trinks, Alexandra ORCID: https://orcid.org/0000-0001-9983-1506, Voijtasova, Dominika ORCID: https://orcid.org/0009-0007-4557-2490, Monaco, Anna Alessandra ORCID: https://orcid.org/0009-0000-5779-3505, Chang, William, Arsie, Roberto ORCID: https://orcid.org/0000-0002-7869-7624, Hu, Marian, Hamdoun, Amro ORCID: https://orcid.org/0000-0003-2568-048X, Jenniches, Chloe, Landthaler, Markus ORCID: https://orcid.org/0000-0002-1075-8734, Blüthgen, Nils ORCID: https://orcid.org/0000-0002-0171-7447 and Garfield, David Aaron ORCID: https://orcid.org/0000-0002-8790-797X
bioRxiv : 2025.08.12.669999. 13 August 2025

Novel non-coding FOXP3 transcript isoform associated to potential transcriptional interference in human regulatory T cells.
Cases, M., Ritter, N., Rincon-Arevalo, H., Kroh, S., Adam, A., Kirchner, M. ORCID: https://orcid.org/0000-0002-7049-534X, Moradian, H., Gossen, M. ORCID: https://orcid.org/0000-0002-1761-4063, Dzamukova, M., Manukyan, A. ORCID: https://orcid.org/0000-0002-0441-9517, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Kressler, C., Hauser, A.E., Depledge, D.P., Polansky, J.K. and Chang, H.D.
RNA Biology 22 (1): 1-20. 2 July 2025

Augmentation of wastewater-based epidemiology with machine learning to support global health surveillance.
Aßmann, E. ORCID: https://orcid.org/0000-0002-7249-069X, Greiner, T., Richard, H. ORCID: https://orcid.org/0000-0001-7776-1340, Wade, M. ORCID: https://orcid.org/0000-0001-9824-7121, Agrawal, S., Amman, F., Böttcher, S., Lackner, S., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Mangul, S., Munteanu, V., Psomopoulos, F. ORCID: https://orcid.org/0000-0002-0222-4273, Smith, M., Trofimova, M., Ullrich, A., von Kleist, M. ORCID: https://orcid.org/0000-0001-6587-6394, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Hölzer, M. and Irrgang, C. ORCID: https://orcid.org/0000-0001-8274-1678
Nature Water 3 (7): 1124. July 2025

DNA virus infections shape transposable elements activity in vitro and in vivo.
Tan, J., Franke, V. ORCID: https://orcid.org/0000-0003-3606-6792, Neugebauer, E., Pennisi, S., Schächtle, M.A., Lagisquet, J., Kuderna, A.K., Walter, S., Welker, I., Ensser, A., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Stamminger, T., Gramberg, T., Akalin, A. ORCID: https://orcid.org/0000-0002-0468-0117, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806 and Full, F.
bioRxiv : 2024.04.18.589901v2. 30 June 2025

Rewired type I IFN signaling is linked to age-dependent differences in COVID-19.
Petrov, Lev, Brumhard, Sophia, Wisniewski, Sebastian, Georg, Philipp, Hiller, Anna, Astaburuaga, Rosario, Blüthgen, Nils, Wyler, Emauel ORCID: https://orcid.org/0000-0002-9884-1806, Vogt, Katrin, Dey, Hannah, von Stillfried, Saskia, Iwert, Christina, Bülow, Roman, Maas, Lukas, Langner, Christine, Meyer, Tim, Loske, Jennifer, Eils, Roland, Lehmann, Irina, Ondruschka, Benjamin, Ralser, Markus, Trimpert, Jakob, Boor, Peter, Bedoui, Sammy, Meisel, Christian, Mall, Marcus, Corman, Victor, Sander, Leif Erik, Röhmel, Jobst and Sawitzki, Birgit
[Dataset] 17 June 2025

Sensitive dissection of a genomic regulatory landscape using bulk and targeted single-cell activation [NuCaptureC].
Vučićević, Dubravka ORCID: https://orcid.org/0000-0002-1162-6709, Hsu, C.W. ORCID: https://orcid.org/0000-0003-3709-9748, Lopez Zepeda, L.S. ORCID: https://orcid.org/0000-0001-9764-0984, Burkert, M. ORCID: https://orcid.org/0000-0002-6721-9985, Hirsekorn, A., Bilić, I. ORCID: https://orcid.org/0000-0002-2730-1634, Kastelić, N., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Lacadie, S.A. ORCID: https://orcid.org/0000-0002-0893-5340 and Ohler, U. ORCID: https://orcid.org/0000-0002-0881-3116
[Dataset] 1 June 2025

SARS-CoV-2 infection of human lung air-liquid interface cultures reveals basal cells as relevant targets.
Baumgardt, M., Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Balázs, A., Löwa, A., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Teixeira Alves, L.G. ORCID: https://orcid.org/0000-0002-5822-4168, Hellwig, K., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Müller, M.A., Drosten, C., Mall, M.A., Hippenstiel, S., Hönzke, K. and Hocke, A.C.
Journal of Infectious Diseases 231 (5): 1210-1220. 15 May 2025

Helmholtz Health task force to strengthen prevention research and its translation globally.

Nature Medicine 31 (5): 1386-1387. May 2025

The cellular and molecular cardiac tissue responses in human inflammatory cardiomyopathies after SARS-CoV-2 infection and COVID-19 vaccination.
Maatz, H. ORCID: https://orcid.org/0000-0002-9232-6272, Lindberg, E.L. ORCID: https://orcid.org/0000-0002-2979-433X, Adami, E. ORCID: https://orcid.org/0000-0002-1813-6681, López-Anguita, N. ORCID: https://orcid.org/0000-0003-3373-7191, Perdomo-Sabogal, A. ORCID: https://orcid.org/0000-0002-1677-8963, Cócera Ortega, L., Patone, G. ORCID: https://orcid.org/0000-0002-7242-0341, Reichart, D., Myronova, A. ORCID: https://orcid.org/0000-0003-2886-2588, Schmidt, S., Elsanhoury, A., Klein, O., Kühl, U., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Yousefian, S. ORCID: https://orcid.org/0000-0003-0902-0369, Haas, S. ORCID: https://orcid.org/0000-0001-9227-2051, Kurth, F. ORCID: https://orcid.org/0000-0002-3807-473X, Teichmann, S.A. ORCID: https://orcid.org/0000-0002-6294-6366, Oudit, G.Y., Milting, H., Noseda, M. ORCID: https://orcid.org/0000-0002-9553-5029, Seidman, J.G., Seidman, C.E. ORCID: https://orcid.org/0000-0002-9082-3566, Heidecker, B., Sander, L.E. ORCID: https://orcid.org/0000-0002-0476-9947, Sawitzki, B. ORCID: https://orcid.org/0000-0001-8166-8579, Klingel, K., Doeblin, P., Kelle, S. ORCID: https://orcid.org/0000-0001-8105-6599, Van Linthout, S., Hubner, N. ORCID: https://orcid.org/0000-0002-1218-6223 and Tschöpe, C.
Nature Cardiovascular Research 4 (3): 330-345. March 2025

Leveraging large language models for data analysis automation.
Jansen, J.A., Manukyan, A. ORCID: https://orcid.org/0000-0002-0441-9517, Al Khoury, N. and Akalin, A. ORCID: https://orcid.org/0000-0002-0468-0117
PLoS ONE 20 (2): e0317084. 21 February 2025

Dissecting the role of RNA-binding proteins in early herpes simplex virus 1 transcription using acute protein depletion.
Barke, N ORCID: https://orcid.org/0009-0004-5862-6628, Masser, S., Stalling, D., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Zinzen, R.P. ORCID: https://orcid.org/0000-0002-8638-5102, Schreiner, S., Bosse, J. and Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734
bioRxiv : 2025.02.10.637450. 11 February 2025

Informationsschatz aus Umweltproben [Treasure trove of information from environmental samples].
Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806 and Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734
BIOspektrum 31 (1): 59-62. February 2025

Herpesviruses mimic zygotic genome activation to promote viral replication.
Neugebauer, E., Walter, S., Tan, J., Drayman, N., Franke, V. ORCID: https://orcid.org/0000-0003-3606-6792, van Gent, M., Pennisi, S., Veratti, P., Stein, K.S., Welker, I., Tay, S., Verjans, G.M.G.M., Timmers, H.T.M., Akalin, A. ORCID: https://orcid.org/0000-0002-0468-0117, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Ensser, A., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806 and Full, F.
Nature Communications 16 (1): 710. 16 January 2025

The deubiquitinase OTUD7B ameliorates central nervous system autoimmunity by inhibiting degradation of glial fibrillary acidic protein and astrocyte hyperinflammation (house mouse).

[Dataset] 10 January 2025

2024

A biomathematical model of SARS-CoV-2 in Syrian hamsters.
Schirm, S., Nouailles, G., Kirsten, H., Trimpert, J., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Teixeira Alves, L.G. ORCID: https://orcid.org/0000-0002-5822-4168, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Ahnert, P., Suttorp, N., Witzenrath, M. and Scholz, M.
Scientific Reports 14 (1): 30541. 18 December 2024

Subcellular mRNA kinetic modeling reveals nuclear retention as rate-limiting.
Steinbrecht, D. ORCID: https://orcid.org/0000-0002-0976-7801, Minia, I. ORCID: https://orcid.org/0000-0003-1012-3373, Milek, M. ORCID: https://orcid.org/0000-0002-0803-8439, Meisig, J., Blüthgen, N. ORCID: https://orcid.org/0000-0002-0171-7447 and Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734
Molecular Systems Biology 20 (12): 1346-1371. 2 December 2024

Effective inhibitor removal from wastewater samples increases sensitivity of RT-dPCR and sequencing analyses and enhances the stability of wastewater-based surveillance.
Linzner, N., Bartel, A. ORCID: https://orcid.org/0000-0002-1280-6138, Schumacher, V., Grau, J.H. ORCID: https://orcid.org/0000-0002-5328-3652, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Preuß, H., Garske, S., Bitzegeio, J., Kirst, E.B., Liere, K. ORCID: https://orcid.org/0000-0003-1504-1449, Hoppe, S., Borodina, T.A. ORCID: https://orcid.org/0000-0002-6978-016X, Altmüller, J. ORCID: https://orcid.org/0000-0003-4372-1521, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Meixner, M., Sagebiel, D. and Böckelmann, U.
Microorganisms 12 (12): 2475. December 2024

Poxviruses induce a nuclear environment in the cytoplasm to promote viral replication.
Veratti, P., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Read, C., Scherer, M., Tan, J., Walther, P., Wider, S., Weidl, D. and Full, F.
bioRxiv : 2024.11.21.624458. 22 November 2024

Neural network-assisted humanisation of COVID-19 hamster transcriptomic data reveals matching severity states in human disease.
Friedrich, V.D., Pennitz, P., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Adler, J.M., Postmus, D., Müller, K., Teixeira Alves, L.G. ORCID: https://orcid.org/0000-0002-5822-4168, Prigann, J., Pott, F., Vladimirova, D., Hoefler, T., Goekeri, C., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Goffinet, C., Saliba, A.E., Scholz, M., Witzenrath, M., Trimpert, J., Kirsten, H. and Nouailles, G.
EBioMedicine 108 : 105312. October 2024

IGF1R is protective in pneumococcal pneumonia.
Felten, M. ORCID: https://orcid.org/0000-0001-5808-5025, Teixeira Alves, L.G. ORCID: https://orcid.org/0000-0002-5822-4168, Letsiou, E., Arnedo, E.A., Piñeiro-Hermida, S., López, I.P., Dietert, K., Firsching, T., Gruber, A.D., Fatykhova, D., Hocke, A., Lingscheid, T., Lienau, J., Rohde, G., Pichel, J.G. and Witzenrath, M.
bioRxiv : 2024.09.11.612370. 11 September 2024

Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19.
Essex, M. ORCID: https://orcid.org/0000-0001-8758-7497, Millet Pascual-Leone, B.L. ORCID: https://orcid.org/0000-0003-4287-282X, Löber, U. ORCID: https://orcid.org/0000-0001-7468-9531, Kuhring, M. ORCID: https://orcid.org/0000-0002-3287-0313, Zhang, B., Brüning, U. ORCID: https://orcid.org/0000-0003-0112-4032, Fritsche-Guenther, R. ORCID: https://orcid.org/0000-0002-6965-0226, Krzanowski, M. ORCID: https://orcid.org/0000-0002-5319-0982, Fiocca Vernengo, F. ORCID: https://orcid.org/0000-0003-2293-5598, Brumhard, S., Röwekamp, I. ORCID: https://orcid.org/0000-0001-8365-2546, Bielecka, A.A., Lesker, T.R., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Mantei, A. ORCID: https://orcid.org/0009-0006-3003-158X, Meisel, C., Caesar, S., Thibeault, C., Corman, V.M. ORCID: https://orcid.org/0000-0002-3605-0136, Marko, L. ORCID: https://orcid.org/0000-0003-1888-5575, Suttorp, N., Strowig, T. ORCID: https://orcid.org/0000-0003-0185-1459, Kurth, F. ORCID: https://orcid.org/0000-0002-3807-473X, Sander, L.E. ORCID: https://orcid.org/0000-0002-0476-9947, Li, Y. ORCID: https://orcid.org/0000-0003-4022-7341, Kirwan, J.A. ORCID: https://orcid.org/0000-0002-5423-1651, Forslund, S.K. ORCID: https://orcid.org/0000-0003-4285-6993 and Opitz, B. ORCID: https://orcid.org/0000-0003-1276-836X
NPJ Biofilms and Microbiomes 10 (1): 66. 1 August 2024

Pathogen dynamics and discovery of novel viruses and enzymes by deep nucleic acid sequencing of wastewater.
Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Lauber, C., Manukyan, A. ORCID: https://orcid.org/0000-0002-0441-9517, Deter, A., Quedenau, C. ORCID: https://orcid.org/0000-0002-6846-4915, Teixeira Alves, L.G. ORCID: https://orcid.org/0000-0002-5822-4168, Wylezich, C. ORCID: https://orcid.org/0000-0002-0436-4480, Borodina, T. ORCID: https://orcid.org/0000-0002-6978-016X, Seitz, S., Altmüller, J. ORCID: https://orcid.org/0000-0003-4372-1521 and Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734
Environment International 190 : 108875. August 2024

Single-cell RNA-sequencing of RVFV infection.
Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806
Methods in Molecular Biology 2824 : 361-372. August 2024

A single-dose MCMV-based vaccine elicits long-lasting immune protection in mice against distinct SARS-CoV-2 variants.
Metzdorf, K., Jacobsen, H., Kim, Y., Teixeira Alves, L.G. ORCID: https://orcid.org/0000-0002-5822-4168, Kulkarni, U., Brdovčak, M.C., Materljan, J., Eschke, K., Chaudhry, M.Z., Hoffmann, M., Bertoglio, F., Ruschig, M., Hust, M., Šustić, M., Krmpotić, A., Jonjić, S., Widera, M., Ciesek, S., Pöhlmann, S., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734 and Čičin-Šain, L.
Frontiers in Immunology 15 : 1383086. 25 July 2024

Grainyhead-like 2 deficiency and kidney cyst growth in a mouse model.
Yurtdas, Z.Y., Kilic, E., Boor, P., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Jung, K. and Schmidt-Ott, K.M. ORCID: https://orcid.org/0000-0002-7700-7142
Journal of the American Society of Nephrology 35 (7): 838-853. July 2024

Single-cell-resolved interspecies comparison shows a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19.
Peidli, S. ORCID: https://orcid.org/0000-0002-4257-8690, Nouailles, G., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Adler, J.M., Kunder, S., Voß, A., Kazmierski, J., Pott, F., Pennitz, P., Postmus, D., Teixeira Alves, L.G. ORCID: https://orcid.org/0000-0002-5822-4168, Goffinet, C., Gruber, A.D., Blüthgen, N. ORCID: https://orcid.org/0000-0002-0171-7447, Witzenrath, M., Trimpert, J., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734 and Praktiknjo, S.D. ORCID: https://orcid.org/0000-0002-0186-5271
Cell Reports 43 (6): 114328. 25 June 2024

Despite the odds: formation of the SARS-CoV-2 methylation complex.
Matsuda, A. ORCID: https://orcid.org/0000-0003-3264-7506, Plewka, J. ORCID: https://orcid.org/0000-0002-0307-0907, Rawski, M., Mourão, A., Zajko, W., Siebenmorgen, T., Kresik, L., Lis, K., Jones, A.N. ORCID: https://orcid.org/0000-0002-2084-3625, Pachota, M., Karim, A., Hartman, K., Nirwal, S., Sonani, R., Chykunova, Y., Minia, I. ORCID: https://orcid.org/0000-0003-1012-3373, Mak, P., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Nowotny, M. ORCID: https://orcid.org/0000-0001-8632-0977, Dubin, G., Sattler, M. ORCID: https://orcid.org/0000-0002-1594-0527, Suder, P., Popowicz, G.M., Pyrć, K. ORCID: https://orcid.org/0000-0002-3867-7688 and Czarna, A.
Nucleic Acids Research 52 (11): 6441-6458. 24 June 2024

AI-guided pipeline for protein-protein interaction drug discovery identifies an SARS-CoV-2 inhibitor.
Trepte, P. ORCID: https://orcid.org/0000-0002-8141-6272, Secker, C. ORCID: https://orcid.org/0000-0002-7222-536X, Olivet, J. ORCID: https://orcid.org/0000-0003-4115-5546, Blavier, J. ORCID: https://orcid.org/0000-0002-7055-6907, Kostova, S. ORCID: https://orcid.org/0000-0002-6842-6732, Maseko, S.B. ORCID: https://orcid.org/0000-0001-7025-6106, Minia, I. ORCID: https://orcid.org/0000-0003-1012-3373, Silva Ramos, E. ORCID: https://orcid.org/0000-0002-8520-9107, Cassonnet, P., Golusik, S., Zenkner, M., Beetz, S., Liebich, M.J., Scharek, N., Schütz, A. ORCID: https://orcid.org/0000-0002-0606-2574, Sperling, M. ORCID: https://orcid.org/0009-0003-9534-3398, Lisurek, M. ORCID: https://orcid.org/0009-0004-7685-5387, Wang, Y., Spirohn, K., Hao, T., Calderwood, M.A. ORCID: https://orcid.org/0000-0001-6475-1418, Hill, D.E. ORCID: https://orcid.org/0000-0001-5192-0921, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Choi, S.G. ORCID: https://orcid.org/0000-0003-0314-3958, Twizere, J.C. ORCID: https://orcid.org/0000-0002-8683-705X, Vidal, M. ORCID: https://orcid.org/0000-0003-3391-5410 and Wanker, E.E. ORCID: https://orcid.org/0000-0001-8072-1630
Molecular Systems Biology 20 (4): 428-457. 2 April 2024

Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19.
Radke, J. ORCID: https://orcid.org/0000-0001-9860-2007, Meinhardt, J. ORCID: https://orcid.org/0000-0003-0366-2416, Aschman, T. ORCID: https://orcid.org/0000-0002-2101-6146, Chua, R.L., Farztdinov, V., Lukassen, S. ORCID: https://orcid.org/0000-0001-7045-6327, Ten, F.W., Friebel, E. ORCID: https://orcid.org/0000-0003-1419-2376, Ishaque, N. ORCID: https://orcid.org/0000-0002-8426-901X, Franz, J. ORCID: https://orcid.org/0000-0001-7523-6622, Huhle, V.H., Mothes, R., Peters, K., Thomas, C. ORCID: https://orcid.org/0000-0002-7386-1181, Schneeberger, S., Schumann, E., Kawelke, L., Jünger, J., Horst, V., Streit, S., von Manitius, R., Körtvélyessy, P., Vielhaber, S., Reinhold, D. ORCID: https://orcid.org/0000-0002-6441-9631, Hauser, A.E., Osterloh, A., Enghard, P., Ihlow, J., Elezkurtaj, S. ORCID: https://orcid.org/0000-0002-1699-1270, Horst, D., Kurth, F. ORCID: https://orcid.org/0000-0002-3807-473X, Müller, M.A. ORCID: https://orcid.org/0000-0003-2242-5117, Gassen, N.C. ORCID: https://orcid.org/0000-0002-4265-3398, Melchert, J. ORCID: https://orcid.org/0000-0002-0494-1022, Jechow, K., Timmermann, B., Fernandez-Zapata, C. ORCID: https://orcid.org/0000-0003-4795-6053, Böttcher, C. ORCID: https://orcid.org/0000-0002-6226-586X, Stenzel, W., Krüger, E. ORCID: https://orcid.org/0000-0002-2551-242X, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Corman, V. ORCID: https://orcid.org/0000-0002-3605-0136, Stadelmann, C. ORCID: https://orcid.org/0000-0003-1766-5458, Ralser, M. ORCID: https://orcid.org/0000-0001-9535-7413, Eils, R., Heppner, F.L. ORCID: https://orcid.org/0000-0001-9816-8917, Mülleder, M. ORCID: https://orcid.org/0000-0001-9792-3861, Conrad, C. ORCID: https://orcid.org/0000-0001-7036-342X and Radbruch, H. ORCID: https://orcid.org/0000-0001-6941-3397
Nature Neuroscience 27 (3): 409-420. March 2024

Protective role of the HSP90 inhibitor, STA-9090, in lungs of SARS-CoV-2-infected Syrian golden hamsters.
Teixeira Alves, L.G. ORCID: https://orcid.org/0000-0002-5822-4168, Baumgardt, M., Langner, C., Fischer, M., Maria Adler, J., Bushe, J., Firsching, T.C., Mastrobuoni, G. ORCID: https://orcid.org/0000-0003-4509-1295, Grobe, J., Hoenzke, K., Kempa, S. ORCID: https://orcid.org/0000-0002-0696-9299, Gruber, A.D., Hocke, A.C., Trimpert, J., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806 and Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734
BMJ Open Respiratory Research 11 (1): e001762. 29 February 2024

Herpes simplex virus type 1 modifies the protein composition of extracellular vesicles to promote neurite outgrowth and neuroinfection.
Sun, G. ORCID: https://orcid.org/0000-0001-7549-7304, Kropp, K.A. ORCID: https://orcid.org/0000-0001-8505-3440, Kirchner, M. ORCID: https://orcid.org/0000-0002-7049-534X, Plückebaum, N. ORCID: https://orcid.org/0000-0002-9788-7335, Selich, A., Serrero, M., Dhingra, A., Cabrera, J.R., Ritter, B., Bauerfeind, R., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Schambach, A., Sodeik, B. ORCID: https://orcid.org/0000-0003-4650-3036, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X and Viejo-Borbolla, A. ORCID: https://orcid.org/0000-0001-6395-4010
mBio 15 (2): e0330823. 14 February 2024

Regulation of lymphoid-myeloid lineage bias through Regnase-1/3-mediated control of Nfkbiz.
Uehata, T., Yamada, S., Ori, D., Vandenbon, A., Giladi, A., Jelinski, A., Murakawa, Y., Watanabe, H., Takeuchi, K., Toratani, K., Mino, T., Kiryu, H., Standley, D.M., Tsujimura, T., Ikawa, T., Kondoh, G., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Kawamoto, H., Rodewald, H.R., Amit, I., Yamamoto, R., Miyazaki, M. and Takeuchi, O.
Blood 143 (3): 243-257. 18 January 2024

2023

VoltRon: a spatial omics analysis platform for multi-resolution and multi-omics integration using image registration.
Manukyan, A. ORCID: https://orcid.org/0000-0002-0441-9517, Bahry, E. ORCID: https://orcid.org/0000-0002-6358-2576, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Becher, E., Pascual-Reguant, Anna, Plumbom, I. ORCID: https://orcid.org/0009-0006-3720-3700, Dikmen, H.O., Elezkurtaj, S., Conrad, T. ORCID: https://orcid.org/0000-0001-5618-6295, Altmüller, J. ORCID: https://orcid.org/0000-0003-4372-1521, Hauser, A.E., Hocke, A., Radbruch, H. ORCID: https://orcid.org/0000-0001-6941-3397, Schmidt, D. ORCID: https://orcid.org/0000-0002-8621-9438, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734 and Akalin, A. ORCID: https://orcid.org/0000-0002-0468-0117
bioRxiv : 2023.12.15.571667. 15 December 2023

The interactive complex between cytomegalovirus kinase vCDK/pUL97 and host factors CDK7-cyclin H determines individual patterns of transcription in infected cells.
Schütz, M., Cordsmeier, A., Wangen, C., Horn, A.H.C. ORCID: https://orcid.org/0000-0003-3539-8103, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Ensser, A. ORCID: https://orcid.org/0000-0001-8873-3863, Sticht, H. ORCID: https://orcid.org/0000-0001-5644-045X and Marschall, M.
International Journal of Molecular Sciences 24 (24): 17421. 13 December 2023

Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles.
Aschman, T. ORCID: https://orcid.org/0000-0002-2101-6146, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Baum, O., Hentschel, A., Rust, R., Legler, F., Preusse, C., Meyer-Arndt, L., Büttnerova, I., Förster, A., Cengiz, D., Teixeira Alves, L.G. ORCID: https://orcid.org/0000-0002-5822-4168, Schneider, J., Kedor, C., Bellmann-Strobl, J., Sanchin, A., Goebel, H.H., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Corman, V., Roos, A., Heppner, F.L., Radbruch, H., Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070, Scheibenbogen, C., Dengler, N.F. and Stenzel, W.
Acta Neuropathologica Communications 11 (1): 193. 8 December 2023

Rat cytomegalovirus efficiently replicates in dendritic cells and induces changes in their transcriptional profile.
Madela-Mönchinger, J.C., Wolf, S.A., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Bauer, A., Mischke, M., Möller, L., Juranić Lisnić, V., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Malyshkina, A. and Voigt, S. ORCID: https://orcid.org/0000-0003-1544-9903
Frontiers in Immunology 14 : 1192057. 23 November 2023

Type I interferons sensitise HIV-1-reactivating T-cells for NK cell-mediated elimination despite HDACi-imposed dysregulation of innate immunity.
Prigann, J., Postmus, D., Pietrobon, A.J., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Jansen, J., Möller, L., Fadejeva, J., Steijaert, T., Fischer, C. ORCID: https://orcid.org/0000-0003-0329-2435, Koppe, U., Gunsenheimer-Bartmeyer, B., Meixenberger, K., Vitcetz, S.N., Sohn, M., Loyal, L., Thiel, A., Sauer, S. ORCID: https://orcid.org/0000-0002-4794-3693, Sutter, K., Dittmer, U., Laue, M., Bannert, N., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734 and Goffinet, C.
bioRxiv : 2020.05.04.075119v3. 19 November 2023

The matrix metalloproteinase ADAM10 supports hepatitis C virus entry and cell-to-cell spread via its sheddase activity.
Carriquí-Madroñal, B. ORCID: https://orcid.org/0000-0002-0640-3041, Sheldon, J., Duven, M., Stegmann, C., Cirksena, K., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Zapatero-Belinchón, F.J., Vondran, F.W.R. and Gerold, G. ORCID: https://orcid.org/0000-0002-1326-5038
PLoS Pathogens 19 (11): e1011759. 15 November 2023

SLAM-Drop-seq reveals mRNA kinetic rates throughout the cell cycle.
Liu, H. ORCID: https://orcid.org/0009-0007-4871-452X, Arsiè, R. ORCID: https://orcid.org/0000-0002-7869-7624, Schwabe, D. ORCID: https://orcid.org/0000-0003-2825-3352, Schilling, M. ORCID: https://orcid.org/0000-0002-3453-7792, Minia, I. ORCID: https://orcid.org/0000-0003-1012-3373, Alles, J. ORCID: https://orcid.org/0000-0003-0681-0410, Boltengagen, A. ORCID: https://orcid.org/0000-0002-8356-9766, Kocks, C. ORCID: https://orcid.org/0000-0003-1749-3334, Falcke, M. ORCID: https://orcid.org/0000-0001-7137-1114, Friedman, N. ORCID: https://orcid.org/0000-0002-9678-3550, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734 and Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332
Molecular Systems Biology 19 (10): e11427. 12 October 2023

Modelling viral encephalitis caused by herpes simplex virus 1 infection in cerebral organoids.
Rybak-Wolf, A. ORCID: https://orcid.org/0000-0002-1192-5290, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Pentimalli, T.M. ORCID: https://orcid.org/0000-0002-8461-7918, Legnini, I. ORCID: https://orcid.org/0000-0002-8984-5215, Oliveras Martinez, A. ORCID: https://orcid.org/0000-0002-5880-5245, Glažar, P. ORCID: https://orcid.org/0000-0003-0842-0088, Loewa, A. ORCID: https://orcid.org/0000-0002-5551-731X, Kim, S.J. ORCID: https://orcid.org/0000-0001-8357-0073, Kaufer, B.B. ORCID: https://orcid.org/0000-0003-1328-2695, Woehler, A. ORCID: https://orcid.org/0000-0001-5157-9313, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734 and Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332
Nature Microbiology 8 (7): 1252-1266. July 2023

The cytomegalovirus M35 protein directly binds to the interferon-β enhancer and modulates transcription of (Ifnb1) and other IRF3-driven genes.
Schwanke, H. ORCID: https://orcid.org/0000-0001-9252-3594, Gonçalves Magalhães, V. ORCID: https://orcid.org/0000-0002-4593-3467, Schmelz, S. ORCID: https://orcid.org/0000-0002-2511-7593, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Hennig, T. ORCID: https://orcid.org/0000-0002-7788-1681, Günther, T. ORCID: https://orcid.org/0000-0001-9650-0218, Grundhoff, A., Dölken, L., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, van Ham, M., Jänsch, L., Büssow, K. ORCID: https://orcid.org/0000-0003-2031-5942, van den Heuvel, J. ORCID: https://orcid.org/0000-0001-5085-4010, Blankenfeldt, W. ORCID: https://orcid.org/0000-0001-9886-9668, Friedel, C.C. ORCID: https://orcid.org/0000-0003-3569-4877, Erhard, F. ORCID: https://orcid.org/0000-0002-3574-6983 and Brinkmann, M.M. ORCID: https://orcid.org/0000-0001-5431-6527
Journal of Virology 97 (6): e0040023. 29 June 2023

Prävention von Infektionskrankheiten mit Abwasser [Prevention of Infectious Diseases with Wastewater].
Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806 and Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734
Arbeitsmedizin Sozialmedizin Umweltmedizin 58 (6): 381-384. June 2023

Global analysis of contact-dependent human-to-mouse intercellular mRNA and lncRNA transfer in cell culture.
Dasgupta, S., Dayagi, D.Y., Haimovich, G., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Olender, T., Singer, R.H., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734 and Gerst, J.E.
eLife 12 : e83584. 30 May 2023

Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters.
Nouailles, G. ORCID: https://orcid.org/0000-0003-1973-3119, Adler, J.M. ORCID: https://orcid.org/0000-0001-8147-0351, Pennitz, P. ORCID: https://orcid.org/0000-0002-8132-7237, Peidli, S. ORCID: https://orcid.org/0000-0002-4257-8690, Teixeira Alves, L.G. ORCID: https://orcid.org/0000-0002-5822-4168, Baumgardt, M. ORCID: https://orcid.org/0000-0003-2077-3716, Bushe, J., Voss, A., Langenhagen, A., Langner, C. ORCID: https://orcid.org/0000-0001-7311-3477, Martin Vidal, R. ORCID: https://orcid.org/0000-0002-9670-5640, Pott, F. ORCID: https://orcid.org/0000-0003-3700-1691, Kazmierski, J. ORCID: https://orcid.org/0000-0002-7962-2165, Ebenig, A. ORCID: https://orcid.org/0000-0001-7066-0184, Lange, M.V., Mühlebach, M.D. ORCID: https://orcid.org/0000-0002-7069-5018, Goekeri, C. ORCID: https://orcid.org/0000-0002-1616-4005, Simmons, S., Xing, N., Abdelgawad, A., Herwig, S., Cichon, G., Niemeyer, D. ORCID: https://orcid.org/0000-0002-1897-6365, Drosten, C. ORCID: https://orcid.org/0000-0001-7923-0519, Goffinet, C. ORCID: https://orcid.org/0000-0002-3959-004X, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Blüthgen, N. ORCID: https://orcid.org/0000-0002-0171-7447, Wu, H., Witzenrath, M., Gruber, A.D. ORCID: https://orcid.org/0000-0002-4502-0393, Praktiknjo, S.D. ORCID: https://orcid.org/0000-0002-0186-5271, Osterrieder, N., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Kunec, D. ORCID: https://orcid.org/0000-0001-6697-7621 and Trimpert, J. ORCID: https://orcid.org/0000-0003-1616-0810
Nature Microbiology 8 (5): 860-874. May 2023

Protocol to dissociate healthy and infected murine- and hamster-derived lung tissue for single-cell transcriptome analysis.
Pennitz, P., Goekeri, C., Trimpert, J., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Ebenig, A., Weissfuss, C., Mühlebach, M.D., Witzenrath, M. and Nouailles, G. ORCID: https://orcid.org/0000-0003-1973-3119
STAR Protocols 4 (1): 101957. 17 March 2023

2022

SARS-CoV-2 infection dynamics revealed by wastewater sequencing analysis and deconvolution.
Schumann, V.F. ORCID: https://orcid.org/0000-0003-0227-7428, de Castro Cuadrat, R.R. ORCID: https://orcid.org/0000-0001-8289-2599, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Wurmus, R. ORCID: https://orcid.org/0009-0003-0140-4189, Deter, A., Quedenau, C. ORCID: https://orcid.org/0000-0002-6846-4915, Dohmen, J. ORCID: https://orcid.org/0000-0002-7826-3025, Faxel, M., Borodina, T. ORCID: https://orcid.org/0000-0002-6978-016X, Blume, A. ORCID: https://orcid.org/0000-0003-3045-8234, Freimuth, J. ORCID: https://orcid.org/0000-0002-9259-3696, Meixner, M., Grau, J.H., Liere, K., Hackenbeck, T., Zietzschmann, F., Gnirss, R., Böckelmann, U., Uyar, B. ORCID: https://orcid.org/0000-0002-3170-4890, Franke, V. ORCID: https://orcid.org/0000-0003-3606-6792, Barke, N. ORCID: https://orcid.org/0009-0004-5862-6628, Altmüller, J. ORCID: https://orcid.org/0000-0003-4372-1521, Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734 and Akalin, A. ORCID: https://orcid.org/0000-0002-0468-0117
Science of the Total Environment 853 : 158931. 20 December 2022

State-of-the-art analytical methods of viral infections in human lung organoids.
Baumgardt, M. ORCID: https://orcid.org/0000-0003-2077-3716, Hülsemann, M., Löwa, A., Fatykhova, D., Hoffmann, K., Kessler, M., Mieth, M., Hellwig, K., Frey, D., Langenhagen, A., Voss, A., Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Dökel, S., Gruber, A.D., Tölch, U., Hippenstiel, S., Hocke, A.C. and Hönzke, K. ORCID: https://orcid.org/0000-0003-0826-2825
PLoS ONE 17 (12): e0276115. 20 December 2022

Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke, K., Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Mache, C., Fathykova, D., Kessler, M., Dökel, S., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Baumgardt, M., Löwa, A., Hoffmann, K., Graff, P., Schulze, J., Mieth, M., Hellwig, K., Demir, Z., Biere, B., Brunotte, L., Mecate-Zambrano, A., Bushe, J., Dohmen, M. ORCID: https://orcid.org/0000-0002-4447-0579, Hinze, C. ORCID: https://orcid.org/0000-0003-2526-1621, Elezkurtaj, S., Tönnies, M., Bauer, T.T., Eggeling, S., Tran, H.L., Schneider, P., Neudecker, J., Rückert, J.C., Schmidt-Ott, K.M. ORCID: https://orcid.org/0000-0002-7700-7142, Busch, J., Klauschen, F., Horst, D., Radbruch, H. ORCID: https://orcid.org/0000-0001-6941-3397, Radke, J., Heppner, F., Corman, V.M., Niemeyer, D., Müller, M.A., Goffinet, C., Mothes, R., Pascual-Reguant, A., Hauser, A.E., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Ludwig, S., Suttorp, N., Witzenrath, M., Gruber, A.D., Drosten, C., Sander, L.E., Wolff, T., Hippenstiel, S. and Hocke, A.C.
European Respiratory Journal 60 (6): 2102725. 1 December 2022

A critical period of translational control during brain development at codon resolution.
Harnett, D. ORCID: https://orcid.org/0000-0002-9190-128X, Ambrozkiewicz, M.C. ORCID: https://orcid.org/0000-0001-5225-5230, Zinnall, U. ORCID: https://orcid.org/0000-0002-0782-7751, Rusanova, A., Borisova, E., Drescher, A.N., Couce-Iglesias, M., Villamil, G. ORCID: https://orcid.org/0000-0001-6701-9505, Dannenberg, R., Imami, K. ORCID: https://orcid.org/0000-0002-7451-4982, Münster-Wandowski, A., Fauler, B., Mielke, T., Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Spahn, C.M.T., Tarabykin, V., Ohler, U. ORCID: https://orcid.org/0000-0002-0881-3116 and Kraushar, M.L.
Nature Structural & Molecular Biology 29 (12): 1277-1290. December 2022

The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants.
Rothenberger, S. ORCID: https://orcid.org/0000-0001-8633-2994, Hurdiss, D.L., Walser, M., Malvezzi, F., Mayor, J., Ryter, S., Moreno, H., Liechti, N. ORCID: https://orcid.org/0000-0003-4354-2419, Bosshart, A., Iss, C., Calabro, V., Cornelius, A., Hospodarsch, T., Neculcea, A., Looser, T., Schlegel, A., Fontaine, S., Villemagne, D. ORCID: https://orcid.org/0000-0002-4465-364X, Paladino, M., Schiegg, D., Mangold, S., Reichen, C., Radom, F., Kaufmann, Y., Schaible, D., Schlegel, I., Zitt, C., Sigrist, G., Straumann, M., Wolter, J., Comby, M., Sacarcelik, F., Drulyte, I., Lyoo, H. ORCID: https://orcid.org/0000-0001-5806-9463, Wang, C., Li, W., Du, W., Binz, H.K. ORCID: https://orcid.org/0000-0003-0702-2280, Herrup, R., Lusvarghi, S. ORCID: https://orcid.org/0000-0003-1793-0450, Neerukonda, S.N., Vassell, R., Wang, W., Adler, J.M. ORCID: https://orcid.org/0000-0001-8147-0351, Eschke, K., Nascimento, M., Abdelgawad, A., Gruber, A.D., Bushe, J. ORCID: https://orcid.org/0000-0001-6103-3277, Kershaw, O., Knutson, C.G., Balavenkatraman, K.K., Ramanathan, K., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Teixeira Alves, L.G. ORCID: https://orcid.org/0000-0002-5822-4168, Lewis, S., Watson, R., Haeuptle, M.A., Zürcher, A., Dawson, K.M. ORCID: https://orcid.org/0000-0002-1770-291X, Steiner, D., Weiss, C.D. ORCID: https://orcid.org/0000-0002-9965-1289, Amstutz, P., van Kuppeveld, F.J.M., Stumpp, M.T. ORCID: https://orcid.org/0000-0001-7356-2061, Bosch, B.J. ORCID: https://orcid.org/0000-0002-3864-232X, Engler, O. ORCID: https://orcid.org/0000-0002-8404-1496 and Trimpert, J. ORCID: https://orcid.org/0000-0003-1616-0810
Nature Biotechnology 40 (12): 1845-1854. December 2022

Integrated genomic surveillance enables tracing of person-to-person SARS-CoV-2 transmission chains during community transmission and reveals extensive onward transmission of travel-imported infections, Germany, June to July 2021.
Houwaart, Torsten, Belhaj, S., Tawalbeh, E., Nagels, D., Fröhlich, Y., Finzer, P., Ciruela, P., Sabrià, A., Herrero, M., Andrés, C., Antón, A., Benmoumene, A., Asskali, D., Haidar, H., von Dahlen, J., Nicolai, J., Stiller, M., Blum, J., Lange, C., Adelmann, C., Schroer, B., Osmers, U., Grice, C., Kirfel, P.P., Jomaa, H., Strelow, D., Hülse, L., Pigulla, M., Kreuzer, P., Tyshaieva, A., Weber, J., Wienemann, T., Kohns Vasconcelos, M., Hoffmann, K., Lübke, N., Hauka, S., Andree, M., Scholz, C.J., Jazmati, N., Göbels, K., Zotz, R., Pfeffer, K., Timm, J., Ehlkes, L., Walker, A. and Dilthey, A.T.
Eurosurveillance 27 (43): 2101089. 27 October 2022

Highly conserved interaction profiles between clinically relevant mutants of the cytomegalovirus CDK-like kinase pUL97 and human cyclins: functional significance of cyclin H.
Schütz, M., Müller, R., Socher, E. ORCID: https://orcid.org/0000-0002-6239-3749, Wangen, C., Full, F., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Wong, D., Scherer, M., Stamminger, T. ORCID: https://orcid.org/0000-0001-9878-3119, Chou, S., Rawlinson, W.D. ORCID: https://orcid.org/0000-0003-0988-7827, Hamilton, S.T., Sticht, H. ORCID: https://orcid.org/0000-0001-5644-045X and Marschall, M.
International Journal of Molecular Sciences 23 (19): 11814. 5 October 2022

A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics.
Pennitz, P. ORCID: https://orcid.org/0000-0002-8132-7237, Kirsten, H., Friedrich, V.D., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Goekeri, C. ORCID: https://orcid.org/0000-0002-1616-4005, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Heinz, G.A., Mashreghi, M.F. ORCID: https://orcid.org/0000-0002-8015-6907, Büttner, M., Trimpert, J., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Suttorp, N., Hocke, A.C., Hippenstiel, S., Tönnies, M., Scholz, M., Kuebler, W.M., Witzenrath, M., Hoenzke, K. and Nouailles, G. ORCID: https://orcid.org/0000-0003-1973-3119
European Respiratory Review 31 (165): 220056. 30 September 2022

Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury.
Hinze, C. ORCID: https://orcid.org/0000-0003-2526-1621, Kocks, C. ORCID: https://orcid.org/0000-0003-1749-3334, Leiz, J. ORCID: https://orcid.org/0000-0002-6531-7047, Karaiskos, N. ORCID: https://orcid.org/0000-0001-7771-3947, Boltengagen, A. ORCID: https://orcid.org/0000-0002-8356-9766, Cao, S. ORCID: https://orcid.org/0000-0001-7195-8193, Skopnik, C.M. ORCID: https://orcid.org/0000-0002-6089-4769, Klocke, J. ORCID: https://orcid.org/0000-0002-7723-9234, Hardenberg, J.H. ORCID: https://orcid.org/0000-0001-9548-2118, Stockmann, H. ORCID: https://orcid.org/0000-0002-0934-7620, Gotthardt, I. ORCID: https://orcid.org/0000-0001-6033-0093, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Haghverdi, L. ORCID: https://orcid.org/0000-0001-9280-9170, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Bachmann, S., Hocke, A.C. ORCID: https://orcid.org/0000-0002-6935-8612, Corman, V., Busch, J., Schneider, W., Himmerkus, N. ORCID: https://orcid.org/0000-0002-2910-6728, Bleich, M. ORCID: https://orcid.org/0000-0002-1745-2295, Eckardt, K.U. ORCID: https://orcid.org/0000-0003-3823-0920, Enghard, P. ORCID: https://orcid.org/0000-0002-7254-3931, Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332 and Schmidt-Ott, K.M. ORCID: https://orcid.org/0000-0002-7700-7142
Genome Medicine 14 (1): 103. 9 September 2022

Human alveolar progenitors generate dual lineage bronchioalveolar organoids.
Hoffmann, K., Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Hönzke, K., Fatykhova, D., Demir, Z. ORCID: https://orcid.org/0000-0001-5329-5517, Löwa, A., Teixeira Alves, L.G. ORCID: https://orcid.org/0000-0002-5822-4168, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Lopez-Rodriguez, E., Mieth, M., Baumgardt, M., Hoppe, J., Firsching, T.C. ORCID: https://orcid.org/0000-0003-1378-4951, Tönnies, M., Bauer, T.T., Eggeling, S., Tran, H.L., Schneider, P., Neudecker, J., Rückert, J.C., Gruber, A.D. ORCID: https://orcid.org/0000-0002-4502-0393, Ochs, M. ORCID: https://orcid.org/0000-0002-0936-6979, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Suttorp, N., Hippenstiel, S., Hocke, A.C. and Kessler, M. ORCID: https://orcid.org/0000-0002-9879-1052
Communications Biology 5 (1): 875. 25 August 2022

Vaccine-associated enhanced respiratory pathology in COVID-19 hamsters after T(H)2-biased immunization.
Ebenig, A., Muraleedharan, S., Kazmierski, J., Todt, D., Auste, A., Anzaghe, M., Gömer, A., Postmus, D., Gogesch, P., Niles, M., Plesker, R., Miskey, C. ORCID: https://orcid.org/0000-0002-7566-9556, Gellhorn Serra, M., Breithaupt, A., Hörner, C., Kruip, C., Ehmann, R., Ivics, Z. ORCID: https://orcid.org/0000-0002-7803-6658, Waibler, Z., Pfaender, S., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Kupke, A., Nouailles, G., Goffinet, C., Brown, R.J.P and Mühlebach, M.D.
Cell Reports 40 (7): 111214. 16 August 2022

De novo whole genome assembly of the Roborovski dwarf hamster (Phodopus roborovskii) genome, an animal model for severe/critical COVID-19.
Andreotti, S. ORCID: https://orcid.org/0000-0001-7678-9720, Altmüller, J. ORCID: https://orcid.org/0000-0003-4372-1521, Quedenau, C. ORCID: https://orcid.org/0000-0002-6846-4915, Borodina, T. ORCID: https://orcid.org/0000-0002-6978-016X, Nouailles, G., Teixeira Alves, L.G. ORCID: https://orcid.org/0000-0002-5822-4168, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Bieniara, M., Trimpert, J. and Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806
Genome Biology and Evolution 14 (7): evac100. July 2022

In vitro Kinase-to-Phosphosite database (iKiP-DB) predicts kinase activity in phosphoproteomic datasets.
Mari, T. ORCID: https://orcid.org/0000-0001-6011-9386, Mösbauer, K., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Drosten, C. and Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751
Journal of Proteome Research 21 (6): 1575-1587. 3 June 2022

HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.
Zinnall, U. ORCID: https://orcid.org/0000-0002-0782-7751, Milek, M. ORCID: https://orcid.org/0000-0002-0803-8439, Minia, I. ORCID: https://orcid.org/0000-0003-1012-3373, Vieira-Vieira, C.H. ORCID: https://orcid.org/0000-0001-5443-4507, Müller, S., Mastrobuoni, G. ORCID: https://orcid.org/0000-0003-4509-1295, Hazapis, O.G., Del Giudice, S. ORCID: https://orcid.org/0000-0003-0194-3767, Schwefel, D. ORCID: https://orcid.org/0000-0002-2945-0908, Bley, N., Voigt, F., Chao, J.A. ORCID: https://orcid.org/0000-0002-5895-9156, Kempa, S. ORCID: https://orcid.org/0000-0002-0696-9299, Hüttelmaier, S. ORCID: https://orcid.org/0000-0001-9335-4227, Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751 and Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734
Nature Communications 13 (1): 2727. 18 May 2022

Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single cell transcriptomics.
Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Adler, J.M., Eschke, K., Teixeira Alves, G. ORCID: https://orcid.org/0000-0002-5822-4168, Peidli, S. ORCID: https://orcid.org/0000-0002-4257-8690, Pott, F., Kazmierski, J., Michalick, L., Kershaw, O., Bushe, J., Andreotti, S., Pennitz, P., Abdelgawad, A., Postmus, D., Goffinet, C., Kreye, J., Reincke, S.M. ORCID: https://orcid.org/0000-0002-8132-3527, Prüss, H., Blüthgen, N. ORCID: https://orcid.org/0000-0002-0171-7447, Gruber, A.D., Kuebler, W.M., Witzenrath, M., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Nouailles, G. and Trimpert, J. ORCID: https://orcid.org/0000-0003-1616-0810
Molecular Therapy 30 (5): 1952-1965. 4 May 2022

Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection clusters based on integrated genomic surveillance, outbreak analysis and contact tracing in an urban setting.
Walker, A., Houwaart, T., Finzer, P., Ehlkes, L., Tyshaieva, A., Damagnez, M., Strelow, D., Duplessis, A., Nicolai, J., Wienemann, T., Tamayo, T., Kohns Vasconcelos, M., Hülse, L., Hoffmann, K., Lübke, N., Hauka, S., Andree, M., Däumer, M.P., Thielen, A., Kolbe-Busch, S., Göbels, K., Zotz, R., Pfeffer, K., Timm, J. and Dilthey, A.T.
Clinical Infectious Diseases 74 (6): 1039-1046. 15 March 2022

Complement activation induces excessive T cell cytotoxicity in severe COVID-19.
Georg, P., Astaburuaga-García, R., Bonaguro, L., Brumhard, S., Michalick, L., Lippert, L.J., Kostevc, T., Gäbel, C., Schneider, M., Streitz, M., Demichev, V., Gemünd, I., Barone, M., Tober-Lau, P., Helbig, E.T., Hillus, D., Petrov, L., Stein, J., Dey, H.P., Paclik, D., Iwert, C., Mülleder, M., Aulakh, S.K., Djudjaj, S., Bülow, R.D., Mei, H.E., Schulz, A.R., Thiel, A., Hippenstiel, S., Saliba, A.E., Eils, R., Lehmann, I., Mall, M.A., Stricker, S., Röhmel, J., Corman, V.M., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, von Stillfried, S., Boor, P., Demir, M., Wesselmann, H., Suttorp, N., Uhrig, A., Müller-Redetzky, H., Nattermann, J., Kuebler, W.M., Meisel, C., Ralser, M., Schultze, J.L., Aschenbrenner, A.C., Thibeault, C., Kurth, F., Sander, L.E., Blüthgen, N. and Sawitzki, B.
Cell 185 (3): 493-512. 3 February 2022

Engineering, decoding and systems-level characterization of chimpanzee cytomegalovirus.
Phan, Q.V., Bogdanow, B., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Liu, F., Hagemeier, C. and Wiebusch, L. ORCID: https://orcid.org/0000-0002-7210-6731
PLoS Pathogens 18 (1): e1010193. 4 January 2022

2021

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
Wendisch, D., Dietrich, O., Mari, T. ORCID: https://orcid.org/0000-0001-6011-9386, von Stillfried, S., Ibarra, I.L., Mittermaier, M., Mache, C., Chua, R.L., Knoll, R., Timm, S., Brumhard, S., Krammer, T., Zauber, H. ORCID: https://orcid.org/0000-0003-2595-1147, Hiller, A.L., Pascual-Reguant, A., Mothes, R., Bülow, R.D., Schulze, J., Leipold, A.M., Djudjaj, S., Erhard, F., Geffers, R., Pott, F., Kazmierski, J., Radke, J., Pergantis, P., Baßler, K., Conrad, C., Aschenbrenner, A.C., Sawitzki, B., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Horst, D., Hippenstiel, S., Hocke, A., Heppner, F.L., Uhrig, A., Garcia, C., Machleidt, F., Herold, S., Elezkurtaj, S., Thibeault, C., Witzenrath, M., Cochain, C., Suttorp, N., Drosten, C., Goffinet, C., Kurth, F., Schultze, J.L., Radbruch, H., Ochs, M., Eils, R., Müller-Redetzky, H., Hauser, A.E., Luecken, M.D., Theis, F.J., Conrad, C., Wolff, T., Boor, P., Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751, Saliba, A.E. and Sander, L.E.
Cell 184 (26): 6243-6261. 22 December 2021

Single-cell analysis of arthritogenic alphavirus-infected human synovial fibroblasts links low abundance of viral RNA to induction of innate immunity and arthralgia-associated gene expression.
Pott, F. ORCID: https://orcid.org/0000-0003-3700-1691, Postmus, D., Brown, R.J.P. ORCID: https://orcid.org/0000-0002-3292-6671, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Neumann, E., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734 and Goffinet, C. ORCID: https://orcid.org/0000-0002-3959-004X
Emerging Microbes & Infections 10 (1): 2151-2168. 16 November 2021

Virus-induced senescence is driver and therapeutic target in COVID-19.
Lee, S. ORCID: https://orcid.org/0000-0002-4614-2931, Yu, Y. ORCID: https://orcid.org/0000-0003-1928-2514, Trimpert, J. ORCID: https://orcid.org/0000-0003-1616-0810, Benthani, F. ORCID: https://orcid.org/0000-0002-3283-307X, Mairhofer, M., Richter-Pechanska, P. ORCID: https://orcid.org/0000-0001-6727-6317, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Belenki, D. ORCID: https://orcid.org/0000-0002-9004-9849, Kaltenbrunner, S., Pammer, M., Kausche, L., Firsching, T.C. ORCID: https://orcid.org/0000-0003-1378-4951, Dietert, K., Schotsaert, M., Martínez-Romero, C. ORCID: https://orcid.org/0000-0001-8888-7715, Singh, G. ORCID: https://orcid.org/0000-0003-3260-2631, Kunz, S. ORCID: https://orcid.org/0000-0002-0131-3506, Niemeyer, D. ORCID: https://orcid.org/0000-0002-1897-6365, Ghanem, R., Salzer, H.J.F., Paar, C., Mülleder, M., Uccellini, M., Michaelis, E.G., Khan, A., Lau, A., Schönlein, M. ORCID: https://orcid.org/0000-0003-3156-3132, Habringer, A., Tomasits, J., Adler, J.M., Kimeswenger, S. ORCID: https://orcid.org/0000-0002-0443-8558, Gruber, A.D. ORCID: https://orcid.org/0000-0002-4502-0393, Hoetzenecker, W., Steinkellner, H., Purfuerst, B. ORCID: https://orcid.org/0000-0002-9887-7577, Motz, R., Di Pierro, F., Lamprecht, B. ORCID: https://orcid.org/0000-0003-3365-3449, Osterrieder, N., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Drosten, C. ORCID: https://orcid.org/0000-0001-7923-0519, García-Sastre, A. ORCID: https://orcid.org/0000-0002-6551-1827, Langer, R., Ralser, M., Eils, R. ORCID: https://orcid.org/0000-0002-0034-4036, Reimann, M. ORCID: https://orcid.org/0000-0002-7876-0128, Fan, D.N.Y. ORCID: https://orcid.org/0000-0001-6826-7076 and Schmitt, C.A. ORCID: https://orcid.org/0000-0002-4731-2226
Nature 599 (7884): 283-289. 11 November 2021

Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.
Krämer, B., Knoll, R. ORCID: https://orcid.org/0000-0001-8320-5885, Bonaguro, L., ToVinh, M. ORCID: https://orcid.org/0000-0002-1625-9741, Raabe, J. ORCID: https://orcid.org/0000-0002-6894-1451, Astaburuaga-García, R., Schulte-Schrepping, J., Kaiser, K.M., Rieke, G.J., Bischoff, J., Monin, M.B., Hoffmeister, C. ORCID: https://orcid.org/0000-0001-6473-4087, Schlabe, S., De Domenico, E., Reusch, N. ORCID: https://orcid.org/0000-0001-5625-0701, Händler, K., Reynolds, G., Blüthgen, N. ORCID: https://orcid.org/0000-0002-0171-7447, Hack, G., Finnemann, C., Nischalke, H.D., Strassburg, C.P., Stephenson, E., Su, Y., Gardner, L., Yuan, D., Chen, D., Goldman, J., Rosenstiel, P., Schmidt, S.V., Latz, E., Hrusovsky, K., Ball, A.J., Johnson, J.M., Koenig, P.A., Schmidt, F.I., Haniffa, M., Heath, J.R., Kümmerer, B.M., Keitel, V., Jensen, B., Stubbemann, P., Kurth, F., Sander, L.E., Sawitzki, B., Aschenbrenner, A.C., Schultze, J.L. and Nattermann, J.
Immunity 54 (11): 2650-2669. 9 November 2021

Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer.
Uhlitz, F. ORCID: https://orcid.org/0000-0001-9176-4660, Bischoff, P. ORCID: https://orcid.org/0000-0002-4442-7116, Peidli, S. ORCID: https://orcid.org/0000-0002-4257-8690, Sieber, A., Trinks, A. ORCID: https://orcid.org/0000-0001-9983-1506, Lüthen, M. ORCID: https://orcid.org/0000-0001-5557-6419, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Ruchiy, Y., Sell, T. ORCID: https://orcid.org/0000-0002-5138-3967, Mamlouk, S. ORCID: https://orcid.org/0000-0001-7285-1320, Arsie, R. ORCID: https://orcid.org/0000-0002-7869-7624, Wei, T.T. ORCID: https://orcid.org/0000-0001-5719-721X, Klotz-Noack, K., Schwarz, R.F. ORCID: https://orcid.org/0000-0001-9155-4268, Sawitzki, B., Kamphues, C., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Sers, C., Horst, D. ORCID: https://orcid.org/0000-0003-4755-5743, Blüthgen, N. ORCID: https://orcid.org/0000-0002-0171-7447 and Morkel, M. ORCID: https://orcid.org/0000-0002-2553-9999
EMBO Molecular Medicine 13 (10): e14123. 7 October 2021

Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses.
Rajasekaran, S. ORCID: https://orcid.org/0000-0002-1271-6204, Siddiqui, J., Rakijas, J., Nicolay, B., Lin, C., Khan, E., Patel, R., Morris, R., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Boukhali, M., Balasubramanyam, J., Ranjith Kumar, R., Van Rechem, C. ORCID: https://orcid.org/0000-0002-5408-6124, Vogel, C., Elchuri, S.V., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Haas, W., Dyson, N. and Miles, W. ORCID: https://orcid.org/0000-0002-2054-5206
Communications Biology 4 (1): 977. 17 August 2021

Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19.
Nouailles, G. ORCID: https://orcid.org/0000-0003-1973-3119, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Pennitz, P. ORCID: https://orcid.org/0000-0002-8132-7237, Postmus, D. ORCID: https://orcid.org/0000-0002-9551-0411, Vladimirova, D., Kazmierski, J. ORCID: https://orcid.org/0000-0002-7962-2165, Pott, F. ORCID: https://orcid.org/0000-0003-3700-1691, Dietert, K. ORCID: https://orcid.org/0000-0002-5667-6750, Muelleder, M., Farztdinov, V., Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Wienhold, S.M. ORCID: https://orcid.org/0000-0001-5655-4350, Andreotti, S., Hoefler, T. ORCID: https://orcid.org/0000-0001-7486-5582, Sawitzki, B., Drosten, C. ORCID: https://orcid.org/0000-0001-7923-0519, Sander, L.E. ORCID: https://orcid.org/0000-0002-0476-9947, Suttorp, N., Ralser, M., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Gruber, A.D. ORCID: https://orcid.org/0000-0002-4502-0393, Goffinet, C. ORCID: https://orcid.org/0000-0002-3959-004X, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Trimpert, J. ORCID: https://orcid.org/0000-0003-1616-0810 and Witzenrath, M.
Nature Communications 12 (1): 4869. 11 August 2021

SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
Gassen, N.C. ORCID: https://orcid.org/0000-0002-4265-3398, Papies, J., Bajaj, T., Emanuel, J. ORCID: https://orcid.org/0000-0002-6246-5255, Dethloff, F., Chua, R.L. ORCID: https://orcid.org/0000-0001-5945-9957, Trimpert, J. ORCID: https://orcid.org/0000-0003-1616-0810, Heinemann, N., Niemeyer, C., Weege, F. ORCID: https://orcid.org/0000-0003-2428-1065, Hönzke, K., Aschman, T. ORCID: https://orcid.org/0000-0002-2101-6146, Heinz, D.E. ORCID: https://orcid.org/0000-0001-7103-9621, Weckmann, K., Ebert, T., Zellner, A., Lennarz, M., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Schroeder, S., Richter, A., Niemeyer, D. ORCID: https://orcid.org/0000-0002-1897-6365, Hoffmann, K., Meyer, T.F., Heppner, F.L. ORCID: https://orcid.org/0000-0001-9816-8917, Corman, V.M. ORCID: https://orcid.org/0000-0002-3605-0136, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Hocke, A.C., Morkel, M. ORCID: https://orcid.org/0000-0002-2553-9999, Osterrieder, N., Conrad, C., Eils, R. ORCID: https://orcid.org/0000-0002-0034-4036, Radbruch, H. ORCID: https://orcid.org/0000-0001-6941-3397, Giavalisco, P., Drosten, C. ORCID: https://orcid.org/0000-0001-7923-0519 and Müller, M.A. ORCID: https://orcid.org/0000-0003-2242-5117
Nature Communications 12 (1): 3818. 21 June 2021

Swarm Learning for decentralized and confidential clinical machine learning.
Warnat-Herresthal, S., Schultze, H., Shastry, K.L., Manamohan, S., Mukherjee, S., Garg, V., Sarveswara, R., Händler, K., Pickkers, P., Aziz, N.A., Ktena, S., Tran, F., Bitzer, M., Ossowski, S., Casadei, N., Herr, C., Petersheim, D., Behrends, U., Kern, F., Fehlmann, T., Schommers, P., Lehmann, C., Augustin, M., Rybniker, J., Altmüller, J. ORCID: https://orcid.org/0000-0003-4372-1521, Mishra, N., Bernardes, J.P., Krämer, B., Bonaguro, L., Schulte-Schrepping, J., De Domenico, E., Siever, C., Kraut, M., Desai, M., Monnet, B., Saridaki, M., Siegel, C.M., Drews, A., Nuesch-Germano, M., Theis, H., Heyckendorf, J., Schreiber, S., Kim-Hellmuth, S., Nattermann, J., Skowasch, D., Kurth, I., Keller, A., Bals, R., Nürnberg, P., Rieß, O., Rosenstiel, P., Netea, M.G., Theis, F., Mukherjee, S., Backes, M., Aschenbrenner, A.C., Ulas, T., Breteler, M.M.B., Giamarellos-Bourboulis, E.J., Kox, M., Becker, M., Cheran, S., Woodacre, M.S., Goh, E.L. and Schultze, J.L.
Nature 594 (7862): 265-270. 10 June 2021

Spatio-temporal mRNA tracking in the early zebrafish embryo.
Holler, K. ORCID: https://orcid.org/0000-0002-5159-9223, Neuschulz, A. ORCID: https://orcid.org/0000-0001-6163-3344, Drewe-Boß, P. ORCID: https://orcid.org/0000-0002-5459-9771, Mintcheva, J. ORCID: https://orcid.org/0000-0003-0793-6277, Spanjaard, B. ORCID: https://orcid.org/0000-0003-1309-8839, Arsiè, R. ORCID: https://orcid.org/0000-0002-7869-7624, Ohler, U. ORCID: https://orcid.org/0000-0002-0881-3116, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734 and Junker, J.P. ORCID: https://orcid.org/0000-0002-2826-8290
Nature Communications 12 : 3358. 7 June 2021

SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells.
Singh, Y. ORCID: https://orcid.org/0000-0001-6919-6273, Trautwein, C., Fendel, R. ORCID: https://orcid.org/0000-0003-4716-0311, Krickeberg, N., Berezhnoy, G., Bissinger, R., Ossowski, S., Salker, M.S., Casadei, N. ORCID: https://orcid.org/0000-0003-2209-0580 and Riess, O.
Heliyon 7 (6): e07147. June 2021

Herpesviral induction of germline transcription factor DUX4 is critical for viral gene expression.
Walter, S., Franke, V. ORCID: https://orcid.org/0000-0003-3606-6792, Drayman, N., Tay, S., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Akalin, A. ORCID: https://orcid.org/0000-0002-0468-0117, Ensser, A. and Full, F.
[Dataset] 21 May 2021

The zinc finger antiviral protein ZAP restricts human cytomegalovirus and selectively binds and destabilizes viral UL4/UL5 transcripts.
Gonzalez-Perez, A.C. ORCID: https://orcid.org/0000-0002-8674-1525, Stempel, M. ORCID: https://orcid.org/0000-0002-9240-3987, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Urban, C., Piras, A., Hennig, T. ORCID: https://orcid.org/0000-0002-7788-1681, Ganskih, S., Wei, Y., Heim, A. ORCID: https://orcid.org/0000-0002-9447-1561, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Pichlmair, A., Dölken, L., Munschauer, M. ORCID: https://orcid.org/0000-0001-6143-4548, Erhard, F. and Brinkmann, M.M. ORCID: https://orcid.org/0000-0001-5431-6527
mBio 12 (3): e02683-20. 4 May 2021

DDX3 depletion represses translation of mRNAs with complex 5' UTRs.
Calviello, L. ORCID: https://orcid.org/0000-0002-5600-0988, Venkataramanan, S. ORCID: https://orcid.org/0000-0002-2507-401X, Rogowski, K.J. ORCID: https://orcid.org/0000-0002-9634-7353, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Wilkins, K., Tejura, M., Thai, B., Krol, J., Filipowicz, W., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734 and Floor, S.N. ORCID: https://orcid.org/0000-0002-9965-9694
Nucleic Acids Research 49 (9): 5336-5350. May 2021

SARS-CoV-2 in humans.
Binder, M. and Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806
Berliner und Munchener Tierarztliche Wochenschrift 134 : 1-13. 30 April 2021

Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy.
Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Mösbauer, K., Franke, V. ORCID: https://orcid.org/0000-0003-3606-6792, Diag, A., Gottula, L.T., Arsiè, R. ORCID: https://orcid.org/0000-0002-7869-7624, Klironomos, F., Koppstein, D. ORCID: https://orcid.org/0000-0002-8618-7237, Hönzke, K., Ayoub, S. ORCID: https://orcid.org/0000-0001-5043-8922, Buccitelli, C. ORCID: https://orcid.org/0000-0002-2637-2131, Hoffmann, K., Richter, A., Legnini, I. ORCID: https://orcid.org/0000-0002-8984-5215, Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, Mari, T. ORCID: https://orcid.org/0000-0001-6011-9386, Del Giudice, S. ORCID: https://orcid.org/0000-0003-0194-3767, Papies, J., Praktiknjo, S. ORCID: https://orcid.org/0000-0002-0186-5271, Meyer, T.F., Müller, M.A., Niemeyer, D., Hocke, A., Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751, Akalin, A. ORCID: https://orcid.org/0000-0002-0468-0117, Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332, Drosten, C. and Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734
iScience 24 (3): 102151. 19 March 2021

Protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit.
Kraushar, M.L. ORCID: https://orcid.org/0000-0002-7359-0318, Krupp, F. ORCID: https://orcid.org/0000-0002-0402-8647, Harnett, D. ORCID: https://orcid.org/0000-0002-9190-128X, Turko, P., Ambrozkiewicz, M.C. ORCID: https://orcid.org/0000-0001-5225-5230, Sprink, T. ORCID: https://orcid.org/0000-0002-0760-6828, Imami, K. ORCID: https://orcid.org/0000-0002-7451-4982, Günnigmann, M., Zinnall, U. ORCID: https://orcid.org/0000-0002-0782-7751, Vieira-Vieira, C.H. ORCID: https://orcid.org/0000-0001-5443-4507, Schaub, T. ORCID: https://orcid.org/0000-0003-0790-5040, Münster-Wandowski, A., Bürger, J., Borisova, E., Yamamoto, H., Rasin, M.R., Ohler, U. ORCID: https://orcid.org/0000-0002-0881-3116, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Mielke, T., Tarabykin, V., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Kramer, G., Vida, I., Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751 and Spahn, C.M.T.
Molecular Cell 81 (2): 304-322. 21 January 2021

CRNKL1 is a highly selective regulator of intron-retaining HIV-1 and cellular mRNAs.
Xiao, H., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Milek, M. ORCID: https://orcid.org/0000-0002-0803-8439, Grewe, B., Kirchner, P., Ekici, A., Silva, A.B.O.V., Jungnickl, D., Full, F., Thomas, M. ORCID: https://orcid.org/0000-0003-4820-2712, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Ensser, A. ORCID: https://orcid.org/0000-0001-8873-3863 and Überla, K. ORCID: https://orcid.org/0000-0001-7822-3835
mBio 12 (1): e02525-20. 19 January 2021

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.
Aschenbrenner, A.C., Mouktaroudi, M., Krämer, B., Oestreich, M., Antonakos, N., Nuesch-Germano, M., Gkizeli, K., Bonaguro, L., Reusch, N., Baßler, K., Saridaki, M., Knoll, R., Pecht, T., Kapellos, T.S., Doulou, S., Kröger, C., Herbert, M., Holsten, L., Horne, A. ORCID: https://orcid.org/0000-0002-4209-4573, Gemünd, I.D., Rovina, N., Agrawal, S., Dahm, K., van Uelft, M., Drews, A., Lenkeit, L., Bruse, N., Gerretsen, J., Gierlich, J., Becker, M., Händler, K., Kraut, M., Theis, H., Mengiste, S., Domenico, E., Schulte-Schrepping, J., Seep, L., Raabe, J., Hoffmeister, C., ToVinh, M., Keitel, V., Rieke, G., Talevi, V., Skowasch, D., Aziz, N.A., Pickkers, P., van de Veerdonk, F.L., Netea, M.G., Schultze, J.L., Kox, M., Breteler, M.M.B., Nattermann, J., Koutsoukou, A., Giamarellos-Bourboulis, E.J. and Ulas, T. ORCID: https://orcid.org/0000-0002-9785-4197
Genome Medicine 13 (1): 7. 13 January 2021

2020

Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells, and plasmablasts as hallmarks of severe COVID-19.
Bernardes, J.P., Mishra, N., Tran, F., Bahmer, T., Best, L., Blase, J.I., Bordoni, D., Franzenburg, J., Geisen, U., Josephs-Spaulding, J., Köhler, P., Künstner, A., Rosati, E., Aschenbrenner, A.C., Bacher, P., Baran, N., Boysen, T., Brandt, B., Bruse, N., Dörr, J., Dräger, A., Elke, G., Ellinghaus, D., Fischer, J., Forster, M., Franke, A., Franzenburg, S., Frey, N., Friedrichs, A., Fuß, J., Glück, A., Hamm, J., Hinrichsen, F., Hoeppner, M.P., Imm, S., Junker, R., Kaiser, S., Kan, Y.H., Knoll, R., Lange, C., Laue, G., Lier, C., Lindner, M., Marinos, G., Markewitz, R., Nattermann, J., Noth, R., Pickkers, P., Rabe, K.F., Renz, A., Röcken, C., Rupp, J., Schaffarzyk, A., Scheffold, A., Schulte-Schrepping, J., Schunk, D., Skowasch, D., Ulas, T., Wandinger, K.P., Wittig, M., Zimmermann, J., Busch, H., Hoyer, B.F., Kaleta, C., Heyckendorf, J., Kox, M., Rybniker, J., Schreiber, S., Schultze, J.L. and Rosenstiel, P.
Immunity 53 (6): 1296-1314. 15 December 2020

4EHP and GIGYF1/2 mediate translation-coupled messenger RNA decay.
Weber, R., Chung, M.Y., Keskeny, C. ORCID: https://orcid.org/0000-0003-3297-7329, Zinnall, U. ORCID: https://orcid.org/0000-0002-0782-7751, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Valkov, E., Izaurralde, E. and Igreja, C.
Cell Reports 33 (2): 108262. 13 October 2020

Severe COVID-19 is marked by a dysregulated myeloid cell compartment.
Schulte-Schrepping, J., Reusch, N., Paclik, D., Baßler, K., Schlickeiser, S., Zhang, B., Krämer, B., Krammer, T., Brumhard, S., Bonaguro, L., De Domenico, E., Wendisch, Da., Grasshoff, M., Kapellos, T.S., Beckstette, M., Pecht, T., Saglam, A., Dietrich, O., Mei, H.E., Schulz, A.R., Conrad, C., Kunkel, D., Vafadarnejad, E., Xu, C.J., Horne, A. ORCID: https://orcid.org/0000-0002-4209-4573, Herbert, M., Drews, A., Thibeault, C., Pfeiffer, M., Hippenstiel, S., Hocke, A., Müller-Redetzky, H., Heim, K.M., Machleidt, F., Uhrig, A., Bosquillon de Jarcy, L., Jürgens, L., Stegemann, M., Glösenkamp, C.R., Volk, H.D., Goffinet, C., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Georg, P., Schneider, M., Dang-Heine, C., Neuwinger, N., Kappert, K., Tauber, R., Corman, V., Raabe, J., Kaiser, K.M., Vinh, M.T., Rieke, G., Meisel, C., Ulas, T., Becker, M., Geffers, R., Witzenrath, M., Drosten, C., Suttorp, N., von Kalle, C., Kurth, F., Händler, K., Schultze, J.L., Aschenbrenner, A.C., Li, Y., Nattermann, J., Sawitzki, B., Saliba, A.E. and Sander, L.E.
Cell 182 (6): 1419-1440. 17 September 2020

Loss of m(1)acp(3)Ψ ribosomal RNA modification is a major feature of cancer.
Babaian, A., Rothe, K. ORCID: https://orcid.org/0000-0001-7190-5024, Girodat, D., Minia, I. ORCID: https://orcid.org/0000-0003-1012-3373, Djondovic, S., Milek, M. ORCID: https://orcid.org/0000-0002-0803-8439, Spencer Miko, S.E., Wieden, H.J., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Morin, G.B. and Mager, D.L.
Cell Reports 31 (5): 107611. 5 May 2020

Mechanism of virus attenuation by codon pair deoptimization.
Groenke, N. ORCID: https://orcid.org/0000-0002-6927-3774, Trimpert, J., Merz, S., Conradie, A.M., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Zhang, H., Hazapis, O.G., Rausch, S., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Osterrieder, N. and Kunec, D. ORCID: https://orcid.org/0000-0001-6697-7621
Cell Reports 31 (4): 107586. 28 April 2020

Integrative functional genomics decodes herpes simplex virus 1.
Whisnant, A.W. ORCID: https://orcid.org/0000-0003-2039-2809, Jürges, C.S. ORCID: https://orcid.org/0000-0001-5617-6601, Hennig, T., Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Prusty, B. ORCID: https://orcid.org/0000-0001-7051-4670, Rutkowski, A.J., L'hernault, A., Djakovic, L. ORCID: https://orcid.org/0000-0002-9368-9403, Göbel, M., Döring, K., Menegatti, J., Antrobus, R., Matheson, N.J. ORCID: https://orcid.org/0000-0002-3318-1851, Künzig, F.W.H. ORCID: https://orcid.org/0000-0003-3730-3905, Mastrobuoni, G. ORCID: https://orcid.org/0000-0003-4509-1295, Bielow, C. ORCID: https://orcid.org/0000-0001-5756-3988, Kempa, S. ORCID: https://orcid.org/0000-0002-0696-9299, Liang, C. ORCID: https://orcid.org/0000-0002-0305-2522, Dandekar, T. ORCID: https://orcid.org/0000-0003-1886-7625, Zimmer, R., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Grässer, F., Lehner, P.J., Friedel, C.C. ORCID: https://orcid.org/0000-0003-3569-4877, Erhard, F. ORCID: https://orcid.org/0000-0002-3574-6983 and Dölken, L. ORCID: https://orcid.org/0000-0002-4651-3544
Nature Communications 11 (1): 2038. 27 April 2020

The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay.
Silla, T., Schmid, M., Dou, Y., Garland, W., Milek, M. ORCID: https://orcid.org/0000-0002-0803-8439, Imami, K. ORCID: https://orcid.org/0000-0002-7451-4982, Johnsen, D., Polak, P., Andersen, J.S., Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734 and Jensen, T. ORCID: https://orcid.org/0000-0001-5127-1239
Nucleic Acids Research 48 (5): 2518-2530. 18 March 2020

2019

Distinct genetic alterations and luminal molecular subtype in nested variant of urothelial carcinoma (NVUC).
Weyerer, V., Weisser, R., Moskalev, E.A. ORCID: https://orcid.org/0000-0002-1798-921X, Haller, F., Stoehr, R., Eckstein, M., Zinnall, U. ORCID: https://orcid.org/0000-0002-0782-7751, Gaisa, N.T., Compérat, E., Perren, A., Keck, B., Allory, Y., Kristiansen, G. ORCID: https://orcid.org/0000-0003-4149-5487, Wullich, B., Agaimy, A., Hartmann, A. and Bertz, S. ORCID: https://orcid.org/0000-0003-0458-7075
Histopathology 75 (6): 865-875. December 2019

Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat.
Labi, V. ORCID: https://orcid.org/0000-0001-7538-1520, Peng, S., Klironomos, F., Munschauer, M. ORCID: https://orcid.org/0000-0001-6143-4548, Kastelic, N., Chakraborty, T., Schoeler, K., Derudder, E. ORCID: https://orcid.org/0000-0003-1421-4045, Martella, M., Mastrobuoni, G. ORCID: https://orcid.org/0000-0003-4509-1295, Hernandez-Miranda, L.R. ORCID: https://orcid.org/0000-0002-0498-708X, Lahmann, I. ORCID: https://orcid.org/0000-0003-0640-4519, Kocks, C. ORCID: https://orcid.org/0000-0003-1749-3334, Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872, Kempa, S. ORCID: https://orcid.org/0000-0002-0696-9299, Quintanilla-Martinez de Fend, L., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Genes & Development 33 : 23-24. 7 November 2019

Codon bias confers stability to human mRNAs.
Hia, F., Yang, S.F., Shichino, Y., Yoshinaga, M., Murakawa, Y., Vandenbon, A., Fukao, A., Fujiwara, T., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Natsume, T., Adachi, S. ORCID: https://orcid.org/0000-0001-5232-411X, Iwasaki, S. and Takeuchi, O. ORCID: https://orcid.org/0000-0002-1260-6232
EMBO Reports 20 (11): e48220. 5 November 2019

Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program.
Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Franke, V. ORCID: https://orcid.org/0000-0003-3606-6792, Menegatti, J., Kocks, C. ORCID: https://orcid.org/0000-0003-1749-3334, Boltengagen, A. ORCID: https://orcid.org/0000-0002-8356-9766, Praktiknjo, S. ORCID: https://orcid.org/0000-0002-0186-5271, Walch-Rückheim, B., Bosse, J. ORCID: https://orcid.org/0000-0001-7252-5541, Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332, Grässer, F., Akalin, A. ORCID: https://orcid.org/0000-0002-0468-0117 and Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734
Nature Communications 10 (1): 4878. 25 October 2019

Label-free detection of global morphology changes in confluent cell layers utilizing quantitative phase imaging with digital holographic microscopy.
Kemper, B., Pohl, L., Kaiser, M., Döpker, E., Schnekenburger, J. and Ketelhut, S.
In: European Conferences on Biomedical Optics 2019, 26-27 Jun 2019, Munich, Germany. 22 July 2019