Browse by Research Team

2023

SLAM-Drop-seq reveals mRNA kinetic rates throughout the cell cycle.
Liu, H. and Arsiè, R. and Schwabe, D. and Schilling, M. and Minia, I. and Alles, J. and Boltengagen, A. and Kocks, C. and Falcke, M. and Friedman, N. and Landthaler, M. and Rajewsky, N.
Molecular Systems Biology 28 August 2023 (In Press)

Modelling viral encephalitis caused by herpes simplex virus 1 infection in cerebral organoids.
Rybak-Wolf, A. and Wyler, E. and Pentimalli, T.M. and Legnini, I. and Oliveras Martinez, A. and Glažar, P. and Loewa, A. and Kim, S.J. and Kaufer, B.B. and Woehler, A. and Landthaler, M. and Rajewsky, N.
Nature Microbiology 8 (7): 1252-1266. July 2023

The cytomegalovirus M35 protein directly binds to the interferon-β enhancer and modulates transcription of (Ifnb1) and other IRF3-driven genes.
Schwanke, H. and Gonçalves Magalhães, V. and Schmelz, S. and Wyler, E. and Hennig, T. and Günther, T. and Grundhoff, A. and Dölken, L. and Landthaler, M. and van Ham, M. and Jänsch, L. and Büssow, K. and van den Heuvel, J. and Blankenfeldt, W. and Friedel, C.C. and Erhard, F. and Brinkmann, M.M.
Journal of Virology 97 (6): e0040023. 29 June 2023

Prävention von Infektionskrankheiten mit Abwasser [Prevention of Infectious Diseases with Wastewater].
Wyler, E. and Landthaler, M.
Arbeitsmedizin Sozialmedizin Umweltmedizin 58 (6): 381-384. June 2023

Global analysis of contact-dependent human-to-mouse intercellular mRNA and lncRNA transfer in cell culture.
Dasgupta, S. and Dayagi, D.Y. and Haimovich, G. and Wyler, E. and Olender, T. and Singer, R.H. and Landthaler, M. and Gerst, J.E.
eLife 12 : e83584. 30 May 2023

Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters.
Nouailles, G. and Adler, J.M. and Pennitz, P. and Peidli, S. and Teixeira Alves, L.G. and Baumgardt, M. and Bushe, J. and Voss, A. and Langenhagen, A. and Langner, C. and Martin Vidal, R. and Pott, F. and Kazmierski, J. and Ebenig, A. and Lange, M.V. and Mühlebach, M.D. and Goekeri, C. and Simmons, S. and Xing, N. and Abdelgawad, A. and Herwig, S. and Cichon, G. and Niemeyer, D. and Drosten, C. and Goffinet, C. and Landthaler, M. and Blüthgen, N. and Wu, H. and Witzenrath, M. and Gruber, A.D. and Praktiknjo, S.D. and Osterrieder, N. and Wyler, E. and Kunec, D. and Trimpert, J.
Nature Microbiology 8 (5): 860-874. May 2023

Protocol to dissociate healthy and infected murine- and hamster-derived lung tissue for single-cell transcriptome analysis.
Pennitz, P. and Goekeri, C. and Trimpert, J. and Wyler, E. and Ebenig, A. and Weissfuss, C. and Mühlebach, M.D. and Witzenrath, M. and Nouailles, G.
STAR Protocols 4 (1): 101957. 17 March 2023 (In Press)

2022

SARS-CoV-2 infection dynamics revealed by wastewater sequencing analysis and deconvolution.
Schumann, V.F. and de Castro Cuadrat, R.R. and Wyler, E. and Wurmus, R. and Deter, A. and Quedenau, C. and Dohmen, J. and Faxel, M. and Borodina, T. and Blume, A. and Freimuth, J. and Meixner, M. and Grau, J.H. and Liere, K. and Hackenbeck, T. and Zietzschmann, F. and Gnirss, R. and Böckelmann, U. and Uyar, B. and Franke, V. and Barke, N. and Altmüller, J. and Rajewsky, N. and Landthaler, M. and Akalin, A.
Science of the Total Environment 853 : 158931. 20 December 2022

State-of-the-art analytical methods of viral infections in human lung organoids.
Baumgardt, M. and Hülsemann, M. and Löwa, A. and Fatykhova, D. and Hoffmann, K. and Kessler, M. and Mieth, M. and Hellwig, K. and Frey, D. and Langenhagen, A. and Voss, A. and Obermayer, B. and Wyler, E. and Dökel, S. and Gruber, A.D. and Tölch, U. and Hippenstiel, S. and Hocke, A.C. and Hönzke, K.
PLoS ONE 17 (12): e0276115. 20 December 2022

Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in severe COVID-19.
Essex, M. and Pascual-Leone, B.M. and Löber, U. and Kuhring, M. and Zhang, B. and Bruening, U. and Fritsche-Guenther, R. and Krzanowski, M. and Vernengo, F.F. and Brumhard, S. and Röwekamp, I. and Bielecka, A.A. and Lesker, T.R. and Wyler, E. and Landthaler, M. and Mantei, A. and Meisel, C. and Caesar, S. and Thiebeault, C. and Corman, V. and Marko, L. and Suttorp, N. and Strowig, T. and Kurth, F. and Sander, L.E. and Li, Y. and Kirwan, J.A. and Forslund, S.K. and Opitz, B.
bioRxiv : 2022.12.02.518860. 2 December 2022

Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke, K. and Obermayer, B. and Mache, C. and Fathykova, D. and Kessler, M. and Dökel, S. and Wyler, E. and Baumgardt, M. and Löwa, A. and Hoffmann, K. and Graff, P. and Schulze, J. and Mieth, M. and Hellwig, K. and Demir, Z. and Biere, B. and Brunotte, L. and Mecate-Zambrano, A. and Bushe, J. and Dohmen, M. and Hinze, C. and Elezkurtaj, S. and Tönnies, M. and Bauer, T.T. and Eggeling, S. and Tran, H.L. and Schneider, P. and Neudecker, J. and Rückert, J.C. and Schmidt-Ott, K.M. and Busch, J. and Klauschen, F. and Horst, D. and Radbruch, H. and Radke, J. and Heppner, F. and Corman, V.M. and Niemeyer, D. and Müller, M.A. and Goffinet, C. and Mothes, R. and Pascual-Reguant, A. and Hauser, A.E. and Beule, D. and Landthaler, M. and Ludwig, S. and Suttorp, N. and Witzenrath, M. and Gruber, A.D. and Drosten, C. and Sander, L.E. and Wolff, T. and Hippenstiel, S. and Hocke, A.C.
European Respiratory Journal 60 (6): 2102725. 1 December 2022

A critical period of translational control during brain development at codon resolution.
Harnett, D. and Ambrozkiewicz, M.C. and Zinnall, U. and Rusanova, A. and Borisova, E. and Drescher, A.N. and Couce-Iglesias, M. and Villamil, G. and Dannenberg, R. and Imami, K. and Münster-Wandowski, A. and Fauler, B. and Mielke, T. and Selbach, M. and Landthaler, M. and Spahn, C.M.T. and Tarabykin, V. and Ohler, U. and Kraushar, M.L.
Nature Structural & Molecular Biology 29 (12): 1277-1290. December 2022

The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants.
Rothenberger, S. and Hurdiss, D.L. and Walser, M. and Malvezzi, F. and Mayor, J. and Ryter, S. and Moreno, H. and Liechti, N. and Bosshart, A. and Iss, C. and Calabro, V. and Cornelius, A. and Hospodarsch, T. and Neculcea, A. and Looser, T. and Schlegel, A. and Fontaine, S. and Villemagne, D. and Paladino, M. and Schiegg, D. and Mangold, S. and Reichen, C. and Radom, F. and Kaufmann, Y. and Schaible, D. and Schlegel, I. and Zitt, C. and Sigrist, G. and Straumann, M. and Wolter, J. and Comby, M. and Sacarcelik, F. and Drulyte, I. and Lyoo, H. and Wang, C. and Li, W. and Du, W. and Binz, H.K. and Herrup, R. and Lusvarghi, S. and Neerukonda, S.N. and Vassell, R. and Wang, W. and Adler, J.M. and Eschke, K. and Nascimento, M. and Abdelgawad, A. and Gruber, A.D. and Bushe, J. and Kershaw, O. and Knutson, C.G. and Balavenkatraman, K.K. and Ramanathan, K. and Wyler, E. and Teixeira Alves, L.G. and Lewis, S. and Watson, R. and Haeuptle, M.A. and Zürcher, A. and Dawson, K.M. and Steiner, D. and Weiss, C.D. and Amstutz, P. and van Kuppeveld, F.J.M. and Stumpp, M.T. and Bosch, B.J. and Engler, O. and Trimpert, J.
Nature Biotechnology 40 (12): 1845-1854. December 2022

Integrated genomic surveillance enables tracing of person-to-person SARS-CoV-2 transmission chains during community transmission and reveals extensive onward transmission of travel-imported infections, Germany, June to July 2021.
Houwaart, Torsten and Belhaj, S. and Tawalbeh, E. and Nagels, D. and Fröhlich, Y. and Finzer, P. and Ciruela, P. and Sabrià, A. and Herrero, M. and Andrés, C. and Antón, A. and Benmoumene, A. and Asskali, D. and Haidar, H. and von Dahlen, J. and Nicolai, J. and Stiller, M. and Blum, J. and Lange, C. and Adelmann, C. and Schroer, B. and Osmers, U. and Grice, C. and Kirfel, P.P. and Jomaa, H. and Strelow, D. and Hülse, L. and Pigulla, M. and Kreuzer, P. and Tyshaieva, A. and Weber, J. and Wienemann, T. and Kohns Vasconcelos, M. and Hoffmann, K. and Lübke, N. and Hauka, S. and Andree, M. and Scholz, C.J. and Jazmati, N. and Göbels, K. and Zotz, R. and Pfeffer, K. and Timm, J. and Ehlkes, L. and Walker, A. and Dilthey, A.T.
Eurosurveillance 27 (43): 2101089. 27 October 2022

Highly conserved interaction profiles between clinically relevant mutants of the cytomegalovirus CDK-like kinase pUL97 and human cyclins: functional significance of cyclin H.
Schütz, M. and Müller, R. and Socher, E. and Wangen, C. and Full, F. and Wyler, E. and Wong, D. and Scherer, M. and Stamminger, T. and Chou, S. and Rawlinson, W.D. and Hamilton, S.T. and Sticht, H. and Marschall, M.
International Journal of Molecular Sciences 23 (19): 11814. 5 October 2022

A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics.
Pennitz, P. and Kirsten, H. and Friedrich, V.D. and Wyler, E. and Goekeri, C. and Obermayer, B. and Heinz, G.A. and Mashreghi, M.F. and Büttner, M. and Trimpert, J. and Landthaler, M. and Suttorp, N. and Hocke, A.C. and Hippenstiel, S. and Tönnies, M. and Scholz, M. and Kuebler, W.M. and Witzenrath, M. and Hoenzke, K. and Nouailles, G.
European Respiratory Review 31 (165): 220056. 30 September 2022

Human alveolar progenitors generate dual lineage bronchioalveolar organoids.
Hoffmann, K. and Obermayer, B. and Hönzke, K. and Fatykhova, D. and Demir, Z. and Löwa, A. and Teixeira Alves, L.G. and Wyler, E. and Lopez-Rodriguez, E. and Mieth, M. and Baumgardt, M. and Hoppe, J. and Firsching, T.C. and Tönnies, M. and Bauer, T.T. and Eggeling, S. and Tran, H.L. and Schneider, P. and Neudecker, J. and Rückert, J.C. and Gruber, A.D. and Ochs, M. and Landthaler, M. and Beule, D. and Suttorp, N. and Hippenstiel, S. and Hocke, A.C. and Kessler, M.
Communications Biology 5 (1): 875. 25 August 2022

Vaccine-associated enhanced respiratory pathology in COVID-19 hamsters after T(H)2-biased immunization.
Ebenig, A. and Muraleedharan, S. and Kazmierski, J. and Todt, D. and Auste, A. and Anzaghe, M. and Gömer, A. and Postmus, D. and Gogesch, P. and Niles, M. and Plesker, R. and Miskey, C. and Gellhorn Serra, M. and Breithaupt, A. and Hörner, C. and Kruip, C. and Ehmann, R. and Ivics, Z. and Waibler, Z. and Pfaender, S. and Wyler, E. and Landthaler, M. and Kupke, A. and Nouailles, G. and Goffinet, C. and Brown, R.J.P and Mühlebach, M.D.
Cell Reports 40 (7): 111214. 16 August 2022

De novo whole genome assembly of the Roborovski dwarf hamster (Phodopus roborovskii) genome, an animal model for severe/critical COVID-19.
Andreotti, S. and Altmüller, J. and Quedenau, C. and Borodina, T. and Nouailles, G. and Teixeira Alves, L.G. and Landthaler, M. and Bieniara, M. and Trimpert, J. and Wyler, E.
Genome Biology and Evolution 14 (7): evac100. July 2022

In vitro Kinase-to-Phosphosite database (iKiP-DB) predicts kinase activity in phosphoproteomic datasets.
Mari, T. and Mösbauer, K. and Wyler, E. and Landthaler, M. and Drosten, C. and Selbach, M.
Journal of Proteome Research 21 (6): 1575-1587. 3 June 2022

HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins.
Zinnall, U. and Milek, M. and Minia, I. and Vieira-Vieira, C.H. and Müller, S. and Mastrobuoni, G. and Hazapis, O.G. and Del Giudice, S. and Schwefel, D. and Bley, N. and Voigt, F. and Chao, J.A. and Kempa, S. and Hüttelmaier, S. and Selbach, M. and Landthaler, M.
Nature Communications 13 (1): 2727. 18 May 2022

Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single cell transcriptomics.
Wyler, E. and Adler, J.M. and Eschke, K. and Teixeira Alves, G. and Peidli, S. and Pott, F. and Kazmierski, J. and Michalick, L. and Kershaw, O. and Bushe, J. and Andreotti, S. and Pennitz, P. and Abdelgawad, A. and Postmus, D. and Goffinet, C. and Kreye, J. and Reincke, S.M. and Prüss, H. and Blüthgen, N. and Gruber, A.D. and Kuebler, W.M. and Witzenrath, M. and Landthaler, M. and Nouailles, G. and Trimpert, J.
Molecular Therapy 30 (5): 1952-1965. 4 May 2022

Global analysis of human-to-mouse contact-dependent intercellular mRNA and lncRNA transfer in cell culture.
Dasgupta, Sandipan and Dyagi, Daniella Y. and Haimovich, Gal and Wyler, E. and Olender, Tsviya and Singer, Robert H. and Landthaler, M. and Gerst, Jeffrey E
bioRxiv : 2021.11.28.470233v2. 7 March 2022

Despite the odds: formation of the SARS-CoV-2 methylation complex.
Matsuda, A. and Plewka, J. and Chykunova, Y. and Jones, A.N. and Pachota, M. and Rawski, M. and Mourão, A. and Karim, A. and Kresik, L. and Lis, K. and Minia, I. and Hartman, K. and Sonani, R. and Schlauderer, F. and Dubin, G. and Sattler, M. and Suder, P. and Popowicz, G. and Pyrć, K. and Czarna, A.
bioRxiv : 2022.01.25.477673. 1 March 2022

Complement activation induces excessive T cell cytotoxicity in severe COVID-19.
Georg, P. and Astaburuaga-García, R. and Bonaguro, L. and Brumhard, S. and Michalick, L. and Lippert, L.J. and Kostevc, T. and Gäbel, C. and Schneider, M. and Streitz, M. and Demichev, V. and Gemünd, I. and Barone, M. and Tober-Lau, P. and Helbig, E.T. and Hillus, D. and Petrov, L. and Stein, J. and Dey, H.P. and Paclik, D. and Iwert, C. and Mülleder, M. and Aulakh, S.K. and Djudjaj, S. and Bülow, R.D. and Mei, H.E. and Schulz, A.R. and Thiel, A. and Hippenstiel, S. and Saliba, A.E. and Eils, R. and Lehmann, I. and Mall, M.A. and Stricker, S. and Röhmel, J. and Corman, V.M. and Beule, D. and Wyler, E. and Landthaler, M. and Obermayer, B. and von Stillfried, S. and Boor, P. and Demir, M. and Wesselmann, H. and Suttorp, N. and Uhrig, A. and Müller-Redetzky, H. and Nattermann, J. and Kuebler, W.M. and Meisel, C. and Ralser, M. and Schultze, J.L. and Aschenbrenner, A.C. and Thibeault, C. and Kurth, F. and Sander, L.E. and Blüthgen, N. and Sawitzki, B.
Cell 185 (3): 493-512. 3 February 2022

Engineering, decoding and systems-level characterization of chimpanzee cytomegalovirus.
Phan, Q.V. and Bogdanow, B. and Wyler, E. and Landthaler, M. and Liu, F. and Hagemeier, C. and Wiebusch, L.
PLoS Pathogens 18 (1): e1010193. 4 January 2022

2021

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
Wendisch, D. and Dietrich, O. and Mari, T. and von Stillfried, S. and Ibarra, I.L. and Mittermaier, M. and Mache, C. and Chua, R.L. and Knoll, R. and Timm, S. and Brumhard, S. and Krammer, T. and Zauber, H. and Hiller, A.L. and Pascual-Reguant, A. and Mothes, R. and Bülow, R.D. and Schulze, J. and Leipold, A.M. and Djudjaj, S. and Erhard, F. and Geffers, R. and Pott, F. and Kazmierski, J. and Radke, J. and Pergantis, P. and Baßler, K. and Conrad, C. and Aschenbrenner, A.C. and Sawitzki, B. and Landthaler, M. and Wyler, E. and Horst, D. and Hippenstiel, S. and Hocke, A. and Heppner, F.L. and Uhrig, A. and Garcia, C. and Machleidt, F. and Herold, S. and Elezkurtaj, S. and Thibeault, C. and Witzenrath, M. and Cochain, C. and Suttorp, N. and Drosten, C. and Goffinet, C. and Kurth, F. and Schultze, J.L. and Radbruch, H. and Ochs, M. and Eils, R. and Müller-Redetzky, H. and Hauser, A.E. and Luecken, M.D. and Theis, F.J. and Conrad, C. and Wolff, T. and Boor, P. and Selbach, M. and Saliba, A.E. and Sander, L.E.
Cell 184 (26): 6243-6261. 22 December 2021

Single-cell analysis of arthritogenic alphavirus-infected human synovial fibroblasts links low abundance of viral RNA to induction of innate immunity and arthralgia-associated gene expression.
Pott, F. and Postmus, D. and Brown, R.J.P. and Wyler, E. and Neumann, E. and Landthaler, M. and Goffinet, C.
Emerging Microbes & Infections 10 (1): 2151-2168. 16 November 2021

Virus-induced senescence is driver and therapeutic target in COVID-19.
Lee, S. and Yu, Y. and Trimpert, J. and Benthani, F. and Mairhofer, M. and Richter-Pechanska, P. and Wyler, E. and Belenki, D. and Kaltenbrunner, S. and Pammer, M. and Kausche, L. and Firsching, T.C. and Dietert, K. and Schotsaert, M. and Martínez-Romero, C. and Singh, G. and Kunz, S. and Niemeyer, D. and Ghanem, R. and Salzer, H.J.F. and Paar, C. and Mülleder, M. and Uccellini, M. and Michaelis, E.G. and Khan, A. and Lau, A. and Schönlein, M. and Habringer, A. and Tomasits, J. and Adler, J.M. and Kimeswenger, S. and Gruber, A.D. and Hoetzenecker, W. and Steinkellner, H. and Purfuerst, B. and Motz, R. and Di Pierro, F. and Lamprecht, B. and Osterrieder, N. and Landthaler, M. and Drosten, C. and García-Sastre, A. and Langer, R. and Ralser, M. and Eils, R. and Reimann, M. and Fan, D.N.Y. and Schmitt, C.A.
Nature 599 : 283-289. 11 November 2021

Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.
Krämer, B. and Knoll, R. and Bonaguro, L. and ToVinh, M. and Raabe, J. and Astaburuaga-García, R. and Schulte-Schrepping, J. and Kaiser, K.M. and Rieke, G.J. and Bischoff, J. and Monin, M.B. and Hoffmeister, C. and Schlabe, S. and De Domenico, E. and Reusch, N. and Händler, K. and Reynolds, G. and Blüthgen, N. and Hack, G. and Finnemann, C. and Nischalke, H.D. and Strassburg, C.P. and Stephenson, E. and Su, Y. and Gardner, L. and Yuan, D. and Chen, D. and Goldman, J. and Rosenstiel, P. and Schmidt, S.V. and Latz, E. and Hrusovsky, K. and Ball, A.J. and Johnson, J.M. and Koenig, P.A. and Schmidt, F.I. and Haniffa, M. and Heath, J.R. and Kümmerer, B.M. and Keitel, V. and Jensen, B. and Stubbemann, P. and Kurth, F. and Sander, L.E. and Sawitzki, B. and Aschenbrenner, A.C. and Schultze, J.L. and Nattermann, J.
Immunity 54 (11): 2650-2669. 9 November 2021

Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer.
Uhlitz, F. and Bischoff, P. and Peidli, S. and Sieber, A. and Trinks, A. and Lüthen, M. and Obermayer, B. and Blanc, E. and Ruchiy, Y. and Sell, T. and Mamlouk, S. and Arsie, R. and Wei, T.T. and Klotz-Noack, K. and Schwarz, R.F. and Sawitzki, B. and Kamphues, C. and Beule, D. and Landthaler, M. and Sers, C. and Horst, D. and Blüthgen, N. and Morkel, M.
EMBO Molecular Medicine 13 (10): e14123. 7 October 2021

Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses.
Rajasekaran, S. and Siddiqui, J. and Rakijas, J. and Nicolay, B. and Lin, C. and Khan, E. and Patel, R. and Morris, R. and Wyler, E. and Boukhali, M. and Balasubramanyam, J. and Ranjith Kumar, R. and Van Rechem, C. and Vogel, C. and Elchuri, S.V. and Landthaler, M. and Obermayer, B. and Haas, W. and Dyson, N. and Miles, W.
Communications Biology 4 (1): 977. 17 August 2021

Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19.
Nouailles, G. and Wyler, E. and Pennitz, P. and Postmus, D. and Vladimirova, D. and Kazmierski, J. and Pott, F. and Dietert, K. and Muelleder, M. and Farztdinov, V. and Obermayer, B. and Wienhold, S.M. and Andreotti, S. and Hoefler, T. and Sawitzki, B. and Drosten, C. and Sander, L.E. and Suttorp, N. and Ralser, M. and Beule, D. and Gruber, A.D. and Goffinet, C. and Landthaler, M. and Trimpert, J. and Witzenrath, M.
Nature Communications 12 (1): 4869. 11 August 2021

Engineering, decoding and systems-level characterization of chimpanzee cytomegalovirus.
Phan, Q.V. and Bogdanow, B. and Wyler, E. and Landthaler, M. and Liu, F. and Hagemeier, C. and Wiebusch, L.
bioRxiv : 2021.07.20.453063. 20 July 2021

Timed global reorganization of protein synthesis during neocortex neurogenesis at codon resolution.
Harnett, D. and Ambrozkiewicz, M.C. and Zinnall, U. and Borisova, E. and Rusanova, A. and Dannenberg, R. and Imami, K. and Münster-Wandowski, A. and Fauler, B. and Mielke, T. and Selbach, M. and Landthaler, M. and Spahn, C.M.T. and Tarabykin, V. and Ohler, U. and Kraushar, M.L.
bioRxiv : 2021.06.23.449626. 24 June 2021

SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
Gassen, N.C. and Papies, J. and Bajaj, T. and Emanuel, J. and Dethloff, F. and Chua, R.L. and Trimpert, J. and Heinemann, N. and Niemeyer, C. and Weege, F. and Hönzke, K. and Aschman, T. and Heinz, D.E. and Weckmann, K. and Ebert, T. and Zellner, A. and Lennarz, M. and Wyler, E. and Schroeder, S. and Richter, A. and Niemeyer, D. and Hoffmann, K. and Meyer, T.F. and Heppner, F.L. and Corman, V.M. and Landthaler, M. and Hocke, A.C. and Morkel, M. and Osterrieder, N. and Conrad, C. and Eils, R. and Radbruch, H. and Giavalisco, P. and Drosten, C. and Müller, M.A.
Nature Communications 12 (1): 3818. 21 June 2021

Complement activation induces excessive T cell cytotoxicity in severe COVID-19.
Georg, P. and Astaburuaga-García, R. and Bonaguro, L. and Brumhard, S. and Michalick, L. and Lippert, L.J. and Kostevc, T. and Gäbel, C. and Schneider, M. and Streitz, M. and Demichev, V. and Gemünd, I. and Barone, M. and Tober-Lau, P. and Helbig, E.T. and Stein, J. and Dey, H.P. and Paclik, D. and Mülleder, M. and Aulakh, S.K. and Mei, H.E. and Schulz, A.R. and Hippenstiel, S. and Corman, V.M. and Beule, D. and Wyler, E. and Landthaler, M. and Obermayer-Wasserscheid, B. and Boor, P. and Demir, M. and Wesselmann, H. and Suttorp, N. and Uhrig, A. and Müller-Redetzky, H. and Nattermann, J. and Kuebler, W.M. and Meisel, C. and Ralser, M. and Schultze, J.L. and Aschenbrenner, A.C. and Thibeault, C. and Kurth, F. and Sander, L.E. and Blüthgen, N. and Sawitzki, B.
medRxiv : 2021.06.08.21258481. 11 June 2021

Single-cell transcriptomic analysis of antiviral responses and viral antagonism in Chikungunya virus-infected synovial fibroblasts.
Pott, F. and Postmus, D. and Brown, R.J.P. and Wyler, E. and Neumann, E. and Landthaler, M. and Goffinet, C.
bioRxiv : 2020.06.07.138610. 11 June 2021

Swarm Learning for decentralized and confidential clinical machine learning.
Warnat-Herresthal, S. and Schultze, H. and Shastry, K.L. and Manamohan, S. and Mukherjee, S. and Garg, V. and Sarveswara, R. and Händler, K. and Pickkers, P. and Aziz, N.A. and Ktena, S. and Tran, F. and Bitzer, M. and Ossowski, S. and Casadei, N. and Herr, C. and Petersheim, D. and Behrends, U. and Kern, F. and Fehlmann, T. and Schommers, P. and Lehmann, C. and Augustin, M. and Rybniker, J. and Altmüller, J. and Mishra, N. and Bernardes, J.P. and Krämer, B. and Bonaguro, L. and Schulte-Schrepping, J. and De Domenico, E. and Siever, C. and Kraut, M. and Desai, M. and Monnet, B. and Saridaki, M. and Siegel, C.M. and Drews, A. and Nuesch-Germano, M. and Theis, H. and Heyckendorf, J. and Schreiber, S. and Kim-Hellmuth, S. and Nattermann, J. and Skowasch, D. and Kurth, I. and Keller, A. and Bals, R. and Nürnberg, P. and Rieß, O. and Rosenstiel, P. and Netea, M.G. and Theis, F. and Mukherjee, S. and Backes, M. and Aschenbrenner, A.C. and Ulas, T. and Breteler, M.M.B. and Giamarellos-Bourboulis, E.J. and Kox, M. and Becker, M. and Cheran, S. and Woodacre, M.S. and Goh, E.L. and Schultze, J.L.
Nature 594 (7862): 265-270. 10 June 2021

Spatio-temporal mRNA tracking in the early zebrafish embryo.
Holler, K. and Neuschulz, A. and Drewe-Boß, P. and Mintcheva, J. and Spanjaard, B. and Arsiè, R. and Ohler, U. and Landthaler, M. and Junker, J.P.
Nature Communications 12 : 3358. 7 June 2021

SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells.
Singh, Y. and Trautwein, C. and Fendel, R. and Krickeberg, N. and Berezhnoy, G. and Bissinger, R. and Ossowski, S. and Salker, M.S. and Casadei, N. and Riess, O.
Heliyon 7 (6): e07147. June 2021

The zinc finger antiviral protein ZAP restricts human cytomegalovirus and selectively binds and destabilizes viral UL4/UL5 transcripts.
Gonzalez-Perez, A.C. and Stempel, M. and Wyler, E. and Urban, C. and Piras, A. and Hennig, T. and Ganskih, S. and Wei, Y. and Heim, A. and Landthaler, M. and Pichlmair, A. and Dölken, L. and Munschauer, M. and Erhard, F. and Brinkmann, M.M.
mBio 12 (3): e02683-20. 4 May 2021

DDX3 depletion represses translation of mRNAs with complex 5' UTRs.
Calviello, L. and Venkataramanan, S. and Rogowski, K.J. and Wyler, E. and Wilkins, K. and Tejura, M. and Thai, B. and Krol, J. and Filipowicz, W. and Landthaler, M. and Floor, S.N.
Nucleic Acids Research 49 (9): 5336-5350. May 2021

SARS-CoV-2 in humans.
Binder, M. and Wyler, E.
Berliner und Munchener Tierarztliche Wochenschrift 134 : 1-13. 30 April 2021

Herpesviral induction of germline transcription factor DUX4 is critical for viral gene expression.
Walter, S. and Franke, V. and Drayman, N. and Wyler, E. and Tay, S. and Landthaler, M. and Akalin, A. and Ensser, A. and Full, F.
bioRxiv : 2021.03.24.436599. 24 March 2021

Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy.
Wyler, E. and Mösbauer, K. and Franke, V. and Diag, A. and Gottula, L.T. and Arsiè, R. and Klironomos, F. and Koppstein, D. and Hönzke, K. and Ayoub, S. and Buccitelli, C. and Hoffmann, K. and Richter, A. and Legnini, I. and Ivanov, A. and Mari, T. and Del Giudice, S. and Papies, J. and Praktiknjo, S. and Meyer, T.F. and Müller, M.A. and Niemeyer, D. and Hocke, A. and Selbach, M. and Akalin, A. and Rajewsky, N. and Drosten, C. and Landthaler, M.
iScience 24 (3): 102151. 19 March 2021

Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection clusters based on integrated genomic surveillance, outbreak analysis and contact tracing in an urban setting.
Walker, A. and Houwaart, T. and Finzer, P. and Ehlkes, L. and Tyshaieva, A. and Damagnez, M. and Strelow, D. and Duplessis, A. and Nicolai, J. and Wienemann, T. and Tamayo, T. and Kohns Vasconcelos, M. and Hülse, L. and Hoffmann, K. and Lübke, N. and Hauka, S. and Andree, M. and Däumer, M.P. and Thielen, A. and Kolbe-Busch, S. and Göbels, K. and Zotz, R. and Pfeffer, K. and Timm, J. and Dilthey, A.T.
Clinical Infectious Diseases 74 (6): 1039-1046. 15 March 2021

Neurodegeneration in human brain organoids infected with herpes simplex virus type 1.
Rybak-Wolf, A. and Wyler, E. and Legnini, I. and Loewa, A. and Glažar, P. and Kim, S.J. and Pentimalli, T.M. and Oliveras Martinez, A. and Beyersdorf, B. and Woehler, A. and Landthaler, M. and Rajewsky, N.
bioRxiv : 2021.03.05.434122. 7 March 2021

Longitudinal omics in Syrian hamsters integrated with human data unravel cellular effector responses to moderate COVID-19.
Nouailles, Geraldine and Wyler, E. and Pennitz, P. and Postmus, D. and Vladrimirova, D. and Kazmierski, J. and Pott, F. and Dietert, K. and Mülleder, M.l and Farztdinov, V. and Obermayer, B. and Wienhold, S.M. and Andreotti, S. and Hoefler, T. and Sawitzki, B. and Drosten, C. and Sander, L. and Suttorp, N. and Ralser, M. and Beule, D. and Gruber, A. and Goffinet, C. and Landthaler, M. and Trimpert, J. and Witzenrath, M.
Research Square : rs-148392/v1. 28 January 2021

Protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit.
Kraushar, M.L. and Krupp, F. and Harnett, D. and Turko, P. and Ambrozkiewicz, M.C. and Sprink, T. and Imami, K. and Günnigmann, M. and Zinnall, U. and Vieira-Vieira, C.H. and Schaub, T. and Münster-Wandowski, A. and Bürger, J. and Borisova, E. and Yamamoto, H. and Rasin, M.R. and Ohler, U. and Beule, D. and Mielke, T. and Tarabykin, V. and Landthaler, M. and Kramer, G. and Vida, I. and Selbach, M. and Spahn, C.M.T.
Molecular Cell 81 (2): 304-322. 21 January 2021

CRNKL1 is a highly selective regulator of intron-retaining HIV-1 and cellular mRNAs.
Xiao, H. and Wyler, E. and Milek, M. and Grewe, B. and Kirchner, P. and Ekici, A. and Silva, A.B.O.V. and Jungnickl, D. and Full, F. and Thomas, M. and Landthaler, M. and Ensser, A. and Überla, K.
mBio 12 (1): e02525-20. 19 January 2021

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients.
Aschenbrenner, A.C. and Mouktaroudi, M. and Krämer, B. and Oestreich, M. and Antonakos, N. and Nuesch-Germano, M. and Gkizeli, K. and Bonaguro, L. and Reusch, N. and Baßler, K. and Saridaki, M. and Knoll, R. and Pecht, T. and Kapellos, T.S. and Doulou, S. and Kröger, C. and Herbert, M. and Holsten, L. and Horne, A. and Gemünd, I.D. and Rovina, N. and Agrawal, S. and Dahm, K. and van Uelft, M. and Drews, A. and Lenkeit, L. and Bruse, N. and Gerretsen, J. and Gierlich, J. and Becker, M. and Händler, K. and Kraut, M. and Theis, H. and Mengiste, S. and Domenico, E. and Schulte-Schrepping, J. and Seep, L. and Raabe, J. and Hoffmeister, C. and ToVinh, M. and Keitel, V. and Rieke, G. and Talevi, V. and Skowasch, D. and Aziz, N.A. and Pickkers, P. and van de Veerdonk, F.L. and Netea, M.G. and Schultze, J.L. and Kox, M. and Breteler, M.M.B. and Nattermann, J. and Koutsoukou, A. and Giamarellos-Bourboulis, E.J. and Ulas, T.
Genome Medicine 13 (1): 7. 13 January 2021

2020

Longitudinal omics in Syrian hamsters integrated with human data unravel complexity of moderate immune responses to SARS-CoV-2.
Nouailles, G. and Wyler, E. and Pennitz, P. and Postmus, D. and Vladimirova, D. and Kazmierski, J. and Pott, F. and Dietert, K. and Mülleder, M. and Farztdinov, V. and Obermayer, B. and Wienhold, S.M. and Andreotti, S. and Höfler, T. and Sawitzki, B. and Drosten, C. and Sander, L.E. and Suttorp, N. and Ralser, M. and Beule, D. and Gruber, A.D. and Goffinet, C. and Landthaler, M. and Trimpert, J. and Witzenrath, M.
bioRxiv : 2020.12.18.423524. 19 December 2020

Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells, and plasmablasts as hallmarks of severe COVID-19.
Bernardes, J.P. and Mishra, N. and Tran, F. and Bahmer, T. and Best, L. and Blase, J.I. and Bordoni, D. and Franzenburg, J. and Geisen, U. and Josephs-Spaulding, J. and Köhler, P. and Künstner, A. and Rosati, E. and Aschenbrenner, A.C. and Bacher, P. and Baran, N. and Boysen, T. and Brandt, B. and Bruse, N. and Dörr, J. and Dräger, A. and Elke, G. and Ellinghaus, D. and Fischer, J. and Forster, M. and Franke, A. and Franzenburg, S. and Frey, N. and Friedrichs, A. and Fuß, J. and Glück, A. and Hamm, J. and Hinrichsen, F. and Hoeppner, M.P. and Imm, S. and Junker, R. and Kaiser, S. and Kan, Y.H. and Knoll, R. and Lange, C. and Laue, G. and Lier, C. and Lindner, M. and Marinos, G. and Markewitz, R. and Nattermann, J. and Noth, R. and Pickkers, P. and Rabe, K.F. and Renz, A. and Röcken, C. and Rupp, J. and Schaffarzyk, A. and Scheffold, A. and Schulte-Schrepping, J. and Schunk, D. and Skowasch, D. and Ulas, T. and Wandinger, K.P. and Wittig, M. and Zimmermann, J. and Busch, H. and Hoyer, B.F. and Kaleta, C. and Heyckendorf, J. and Kox, M. and Rybniker, J. and Schreiber, S. and Schultze, J.L. and Rosenstiel, P.
Immunity 53 (6): 1296-1314. 15 December 2020

Spatio-temporal mRNA dynamics in the early zebrafish embryo.
Holler, K. and Neuschulz, A. and Drewe-Boß, P. and Mintcheva, J. and Spanjaard, B. and Arsiè, R. and Ohler, U. and Landthaler, M. and Junker, J.P.
bioRxiv : 020.11.19.389809. 20 November 2020

4EHP and GIGYF1/2 mediate translation-coupled messenger RNA decay.
Weber, R. and Chung, M.Y. and Keskeny, C. and Zinnall, U. and Landthaler, M. and Valkov, E. and Izaurralde, E. and Igreja, C.
Cell Reports 33 (2): 108262. 13 October 2020

Severe COVID-19 is marked by a dysregulated myeloid cell compartment.
Schulte-Schrepping, J. and Reusch, N. and Paclik, D. and Baßler, K. and Schlickeiser, S. and Zhang, B. and Krämer, B. and Krammer, T. and Brumhard, S. and Bonaguro, L. and De Domenico, E. and Wendisch, Da. and Grasshoff, M. and Kapellos, T.S. and Beckstette, M. and Pecht, T. and Saglam, A. and Dietrich, O. and Mei, H.E. and Schulz, A.R. and Conrad, C. and Kunkel, D. and Vafadarnejad, E. and Xu, C.J. and Horne, A. and Herbert, M. and Drews, A. and Thibeault, C. and Pfeiffer, M. and Hippenstiel, S. and Hocke, A. and Müller-Redetzky, H. and Heim, K.M. and Machleidt, F. and Uhrig, A. and Bosquillon de Jarcy, L. and Jürgens, L. and Stegemann, M. and Glösenkamp, C.R. and Volk, H.D. and Goffinet, C. and Landthaler, M. and Wyler, E. and Georg, P. and Schneider, M. and Dang-Heine, C. and Neuwinger, N. and Kappert, K. and Tauber, R. and Corman, V. and Raabe, J. and Kaiser, K.M. and Vinh, M.T. and Rieke, G. and Meisel, C. and Ulas, T. and Becker, M. and Geffers, R. and Witzenrath, M. and Drosten, C. and Suttorp, N. and von Kalle, C. and Kurth, F. and Händler, K. and Schultze, J.L. and Aschenbrenner, A.C. and Li, Y. and Nattermann, J. and Sawitzki, B. and Saliba, A.E. and Sander, L.E.
Cell 182 (6): 1419-1440. 17 September 2020

The zinc finger antiviral protein ZAP destabilises viral transcripts and restricts human cytomegalovirus.
Gonzalez-Perez, A.C. and Stempel, M. and Wyler, E. and Urban, C. and Piras, A. and Hennig, T. and Heim, A. and Landthaler, M. and Pichlmair, A. and Erhard, F. and Dölken, L. and Brinkmann, M.M.
bioRxiv : 2020.09.15.297804. 17 September 2020

Bulk and single-cell gene expression profiling of SARS-CoV-2 infected human cell lines identifies molecular targets for therapeutic intervention.
Wyler, E. and Mösbauer, K. and Franke, V. and Diag, A. and Gottula, L.T. and Arsie, R. and Klironomos, F. and Koppstein, D. and Ayoub, S. and Buccitelli, C. and Richter, A. and Legnini, I. and Ivanov, A. and Mari, T. and Del Giudice, S. and Papies, J.P. and Müller, M.A. and Niemeyer, D. and Selbach, M. and Akalin, A. and Rajewsky, N. and Drosten, C. and Landthaler, M.
bioRxiv : 2020.05.05.079194. 5 May 2020

Loss of m(1)acp(3)Ψ ribosomal RNA modification is a major feature of cancer.
Babaian, A. and Rothe, K. and Girodat, D. and Minia, I. and Djondovic, S. and Milek, M. and Spencer Miko, S.E. and Wieden, H.J. and Landthaler, M. and Morin, G.B. and Mager, D.L.
Cell Reports 31 (5): 107611. 5 May 2020

Single cell RNA-sequencing-based analysis of CD4(+) T-cell subset-specific susceptibility to transcriptional modulation by HIV-1 latency-reversing agents.
Kazmierski, J. and Postmus, D. and Wyler, E. and Fischer, C. and Jansen, J. and Meixenberger, K. and Vitcetz, S.N. and Sohn, M. and Sauer, S. and Bannert, N. and Landthaler, M. and Goffinet, C.
bioRxiv : 2020.05.04.075119. 5 May 2020

Mechanism of virus attenuation by codon pair deoptimization.
Groenke, N. and Trimpert, J. and Merz, S. and Conradie, A.M. and Wyler, E. and Zhang, H. and Hazapis, O.G. and Rausch, S. and Landthaler, M. and Osterrieder, N. and Kunec, D.
Cell Reports 31 (4): 107586. 28 April 2020

Integrative functional genomics decodes herpes simplex virus 1.
Whisnant, A.W. and Jürges, C.S. and Hennig, T. and Wyler, E. and Prusty, B. and Rutkowski, A.J. and L'hernault, A. and Djakovic, L. and Göbel, M. and Döring, K. and Menegatti, J. and Antrobus, R. and Matheson, N.J. and Künzig, F.W.H. and Mastrobuoni, G. and Bielow, C. and Kempa, S. and Liang, C. and Dandekar, T. and Zimmer, R. and Landthaler, M. and Grässer, F. and Lehner, P.J. and Friedel, C.C. and Erhard, F. and Dölken, L.
Nature Communications 11 (1): 2038. 27 April 2020

The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay.
Silla, T. and Schmid, M. and Dou, Y. and Garland, W. and Milek, M. and Imami, K. and Johnsen, D. and Polak, P. and Andersen, J.S. and Selbach, M. and Landthaler, M. and Jensen, T.
Nucleic Acids Research 48 (5): 2518-2530. 18 March 2020

CRNKL1 is a highly selective regulator of intron-retaining HIV-1 and cellular mRNAs.
Xiao, H. and Wyler, E. and Milek, M. and Grewe, B. and Kirchner, P. and Ekici, A. and Villela Silva, A.B.O. and Jungnickl, D. and Landthaler, M. and Ensser, A. and Überla, K.
bioRxiv : 2020.02.04.934927. 11 February 2020

The architecture of protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit.
Kraushar, M.L. and Krupp, F. and Turko, P. and Ambrozkiewicz, M.C. and Sprink, T. and Imami, K. and Vieira-Vieira, C.H. and Schaub, T. and Harnett, D. and Münster-Wandowski, A. and Bürger, J. and Zinnall, U. and Borisova, E. and Yamamoto, H. and Rasin, M.R. and Beule, D. and Landthaler, M. and Mielke, T. and Tarabykin, V. and Vida, I. and Selbach, M. and Spahn, C.M.T.
bioRxiv : 2020.02.08.939488. 10 February 2020

2019

Distinct genetic alterations and luminal molecular subtype in nested variant of urothelial carcinoma (NVUC).
Weyerer, V. and Weisser, R. and Moskalev, E.A. and Haller, F. and Stoehr, R. and Eckstein, M. and Zinnall, U. and Gaisa, N.T. and Compérat, E. and Perren, A. and Keck, B. and Allory, Y. and Kristiansen, G. and Wullich, B. and Agaimy, A. and Hartmann, A. and Bertz, S.
Histopathology 75 (6): 865-875. December 2019

Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis.
Bogdanow, B. and Schmidt, M. and Weisbach, H. and Gruska, I. and Vetter, B. and Imami, K. and Ostermann, E. and Brune, W. and Selbach, M. and Hagemeier, C. and Wiebusch, L.
bioRxiv : 856435. 26 November 2019

Loss of m(1)acp(3)Ψ ribosomal RNA modification is a major feature of cancer.
Babaian, A. and Rothe, K. and Girodat, D. and Minia, I. and Djondovic, S. and Milek, M. and Wieden, H.J. and Landthaler, M. and Morin, G. and Mager, D.L.
bioRxiv : 840132. 13 November 2019

Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat.
Labi, V. and Peng, S. and Klironomos, F. and Munschauer, M. and Kastelic, N. and Chakraborty, T. and Schoeler, K. and Derudder, E. and Martella, M. and Mastrobuoni, G. and Hernandez-Miranda, L.R. and Lahmann, I. and Kocks, C. and Birchmeier, C. and Kempa, S. and Quintanilla-Martinez de Fend, L. and Landthaler, M. and Rajewsky, N. and Rajewsky, K.
Genes & Development 33 : 23-24. 7 November 2019

Codon bias confers stability to human mRNAs.
Hia, F. and Yang, S.F. and Shichino, Y. and Yoshinaga, M. and Murakawa, Y. and Vandenbon, A. and Fukao, A. and Fujiwara, T. and Landthaler, M. and Natsume, T. and Adachi, S. and Iwasaki, S. and Takeuchi, O.
EMBO Reports 20 (11): e48220. 5 November 2019

Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program.
Wyler, E. and Franke, V. and Menegatti, J. and Kocks, C. and Boltengagen, A. and Praktiknjo, S. and Walch-Rückheim, B. and Bosse, J. and Rajewsky, N. and Grässer, F. and Akalin, A. and Landthaler, M.
Nature Communications 10 (1): 4878. 25 October 2019

Label-free detection of global morphology changes in confluent cell layers utilizing quantitative phase imaging with digital holographic microscopy.
Kemper, B. and Pohl, L. and Kaiser, M. and Döpker, E. and Schnekenburger, J. and Ketelhut, S.
In: European Conferences on Biomedical Optics 2019, 26-27 Jun 2019, Munich, Germany. 22 July 2019

The translational landscape of the human heart.
van Heesch, S. and Witte, F. and Schneider-Lunitz, V. and Schulz, J.F. and Adami, E. and Faber, A. and Kirchner, M. and Maatz, H. and Blachut, S. and Sandmann, C.L. and Kanda, M. and Worth, C.L. and Schafer, S. and Calviello, L. and Merriott, R. and Patone, G. and Hummel, O. and Wyler, E. and Obermayer, B. and Mücke, M. and Lindberg, E.L. and Trnka, F. and Memczak, S. and Schilling, M. and Felkin, L.E. and Barton, P.J.R. and Quaife, N.M. and Vanezis, K. and Diecke, S. and Mukai, M. and Mah, N. and Oh, S.J. and Kurtz, A. and Schramm, C. and Schwinge, D. and Sebode, M. and Harakalova, M. and Asselbergs, F.W. and Vink, A. and de Weger, R.A. and Viswanathan, S. and Widjaja, A.A. and Gärtner-Rommel, A. and Milting, H. and Dos Remedios, C. and Knosalla, C. and Mertins, P. and Landthaler, M. and Vingron, M. and Linke, W.A. and Seidman, J.G. and Seidman, C.E. and Rajewsky, N. and Ohler, U. and Cook, S.A. and Hubner, N.
Cell 178 (1): 242-260. 27 June 2019

Mutant FUS and ELAVL4 (HuD) aberrant crosstalk in amyotrophic lateral sclerosis.
De Santis, R. and Alfano, V. and de Turris, V. and Colantoni, A. and Santini, L. and Garone, M.G. and Antonacci, G. and Peruzzi, G. and Sudria-Lopez, E. and Wyler, E. and Anink, J.J. and Aronica, E. and Landthaler, M. and Pasterkamp, R.J. and Bozzoni, I. and Rosa, A.
Cell Reports 27 (13): 3818-3831. 25 June 2019

Integrative functional genomics decodes herpes simplex virus 1.
Whisnant, A.W. and Jürges, C.S. and Hennig, T. and Wyler, E. and Prusty, B. and Rutkowski, A.J. and L’hernault, A. and Göbel, M. and Döring, K. and Menegatti, J. and Antrobus, R. and Matheson, N.J. and Künzig, F.W.H. and Mastrobuoni, G. and Bielow, C. and Kempa, S. and Chunguang, L. and Dandekar, T. and Zimmer, R. and Landthaler, M. and Grässer, F. and Lehner, P.J. and Friedel, C.C. and Erhard, F. and Dölken, L.
bioRxiv : 603654. 9 April 2019

Codon bias confers stability to mRNAs via ILF2 in humans.
Hia, F. and Yang, S.F. and Shichino, Y. and Yoshinaga, M. and Murakawa, Y. and Vandenbon, A. and Fukao, A. and Fujiwara, T. and Landthaler, M. and Natsume, T. and Adachi, S. and Iwasaki, S. and Takeuchi, O.
bioRxiv : 585992. 4 April 2019

DDX3 depletion selectively represses translation of structured mRNAs.
Calviello, L. and Venkataramanan, S. and Rogowski, K.J. and Wyler, E. and Tejura, M. and Thai, B. and Krol, J. and Filipowicz, W. and Landthaler, M. and Floor, S.N.
bioRxiv : 589218. 26 March 2019

Nanocapsule induced morphology and migration changes in single cell layers quantified with digital holographic microscopy.
Kaiser, M. and Pohl, L. and Ketelhut, S. and Kastl, L. and Gorzelanny, C. and Götte, M. and Schnekenburger, J. and Goycoolea, F.M. and Kemper, B.
In: SPIE BiOS 2019, 2-7 Feb 2019, San Francisco, CA, USA. 4 March 2019

Quantitative phase imaging-based concepts for the analysis of global morphology changes in confluent cell layers.
Kemper, B. and Pohl, L. and Kaiser, M. and Doepker, E. and Schnekenburger, J. and Ketelhut, S.
In: SPIE BiOS 2019, 2-7 Feb 2019, San Francisco, CA, USA. 4 March 2019

Single-cell RNA-sequencing of Herpes simplex virus 1-infected cells identifies NRF2 activation as an antiviral program.
Wyler, E. and Franke, V. and Menegatti, J. and Kocks, C. and Boltengagen, A. and Praktiknjo, S. and Walch-Rückheim, B. and Rajewsky, N. and Grässer, F. and Akalin, A. and Landthaler, M.
bioRxiv : 566992. 4 March 2019

2018

The influence of capsaicin on the integrity of microvascular endothelial cell monolayers.
Kaiser, M. and Burek, M. and Britz, S. and Lankamp, F. and Ketelhut, S. and Kemper, B. and Förster, C. and Gorzelanny, C. and Goycoolea, F.M.
International Journal of Molecular Sciences 20 (1): 122. 30 December 2018

A gene expression atlas of embryonic neurogenesis in Drosophila reveals complex spatiotemporal regulation of lncRNAs.
McCorkindale, A.L. and Wahle, P. and Werner, S. and Jungreis, I. and Menzel, P. and Shukla, C.J. and Lopes Pereira Abreu, R. and Irizarry, Rafael and Meyer, I. and Kellis, Manolis and Zinzen, R.P.
bioRxiv : 483461. 27 December 2018

New insights into the cellular temporal response to proteostatic stress.
Rendleman, J. and Cheng, Z. and Maity, S. and Kastelic, N. and Munschauer, M. and Allgoewer, K. and Teo, G. and Zhang, Y.B.M. and Lei, A. and Parker, B. and Landthaler, M. and Freeberg, L. and Kuersten, S. and Choi, H. and Vogel, C.
eLife 7 : e39054. 12 October 2018

Phosphorylation of the ribosomal protein RPL12/uL11 affects translation during mitosis.
Imami, K. and Milek, M. and Bogdanow, B. and Yasuda, T. and Kastelic, N. and Zauber, H. and Ishihama, Y. and Landthaler, M. and Selbach, M.
Molecular Cell 72 (1): 84-98. 4 October 2018

Micropapillary urothelial carcinoma: evaluation of HER2 status and immunohistochemical characterization of the molecular subtype.
Zinnall, U. and Weyerer, V. and Compérat, E. and Camparo, P. and Gaisa, N.T. and Knuechel-Clarke, R. and Perren, A. and Lugli, A. and Toma, M. and Baretton, G. and Kristiansen, G. and Wirtz, R.M. and Cheng, L. and Wullich, B. and Stoehr, R. and Hartmann, A. and Bertz, S.
Human Pathology 80 : 55-64. October 2018

Quantifying multi-layered expression regulation in response to stress of the endoplasmic reticulum.
Rendleman, J. and Cheng, Z. and Maity, S. and Kastelic, N. and Munschauer, M. and Allgoewer, K. and Teo, G. and Zhang, Y.B. and Lei, A. and Parker, B. and Landthaler, M. and Freeberg, L. and Kuersten, S. and Choi, H. and Vogel, C.
bioRxiv : 308379. 25 April 2018

Expanding the map of protein-RNA interaction sites via cell fusion followed by PAR-CLIP.
Hinze, F. and Drewe-Boss, P. and Milek, M. and Ohler, U. and Landthaler, M. and Gotthardt, M.
RNA Biology 15 (3): 359-368. 4 March 2018

Systematic detection of poly(A)(+) RNA-interacting proteins and their differential binding.
Milek, M. and Landthaler, M.
Methods in Molecular Biology 1649 : 405-417. 2018

2017

Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infection.
Wyler, E. and Menegatti, J. and Franke, V. and Kocks, C. and Boltengagen, A. and Hennig, T. and Theil, K. and Rutkowski, A. and Ferrai, C. and Baer, L. and Kermas, L. and Friedel, C. and Rajewsky, N. and Akalin, A. and Dölken, L. and Grässer, F. and Landthaler, M.
Genome Biology 18 (1): 209. 31 October 2017

mRNA interactome capture in mammalian cells.
Kastelic, N. and Landthaler, M.
Methods 126 : 38-43. 15 August 2017

Rattus norvegicus BN/SHR liver and heart left ventricle ribosomal RNA depleted directional RNA sequencing.
Wyler, E. and van Heesch, S. and Adami, E. and Hubner, N. and Landthaler, M.
BMC Research Notes 10 (1): 395. 11 August 2017

DDX54 regulates transcriptome dynamics during DNA damage response.
Milek, M. and Imami, K. and Mukherjee, N. and De Bortoli, F. and Zinnall, U. and Hazapis, O. and Trahan, C. and Oeffinger, M. and Heyd, F. and Ohler, U. and Selbach, M. and Landthaler, M.
Genome Research 27 (8): 1344-1359. August 2017

An immediate-late gene expression module decodes ERK signal duration.
Uhlitz, F. and Sieber, A. and Wyler, E. and Fritsche-Guenther, R. and Meisig, J. and Landthaler, M. and Klinger, B. and Blüthgen, N.
Molecular Systems Biology 13 (5): 928. 3 May 2017

Translation of circRNAs.
Pamudurti, N.R. and Bartok, O. and Jens, M. and Ashwal-Fluss, R. and Stottmeister, C. and Ruhe, L. and Hanan, M. and Wyler, E. and Perez-Hernandez, D. and Ramberger, E. and Shenzis, S. and Samson, M. and Dittmar, G. and Landthaler, M. and Chekulaeva, M. and Rajewsky, N. and Kadener, S.
Molecular Cell 66 (1): 9-21. 6 April 2017

Transcriptome-wide identification of RNA-binding protein binding sites using photoactivatable-ribonucleoside-enhanced crosslinking immunoprecipitation (PAR-CLIP).
Maatz, H. and Kolinski, M. and Hubner, N. and Landthaler, M.
Current Protocols in Molecular Biology 118 : 27.6.1-27.6.19. 3 April 2017

JACUSA: site-specific identification of RNA editing events from replicate sequencing data.
Piechotta, M. and Wyler, E. and Ohler, U. and Landthaler, M. and Dieterich, C.
BMC Bioinformatics 18 (1): 7. 3 January 2017

2016

Eyes on translation.
Chekulaeva, M. and Landthaler, M.
Molecular Cell 63 (6): 918-925. 15 September 2016

The Lupus autoantigen La prevents Mis-channeling of tRNA fragments into the human microRNA pathway.
Hasler, D. and Lehmann, G. and Murakawa, Y. and Klironomos, F. and Jakob, L. and Grässer, F.A. and Rajewsky, N. and Landthaler, M. and Meister, G.
Molecular Cell 63 (1): 110-124. 7 July 2016

The mRNA-bound proteome of the early fly embryo.
Wessels, H.H. and Imami, K. and Baltz, A.G. and Kolinski, M. and Beldovskaya, A. and Selbach, M. and Small, S. and Ohler, U. and Landthaler, M.
Genome Research 26 (7): 1000-1009. July 2016

TERT core promotor mutations in early-onset bladder cancer.
Giedl, J. and Rogler, A. and Wild, A. and Riener, M.O. and Filbeck, T. and Burger, M. and Ruemmele, P. and Hurst, C. and Knowles, M. and Hartmann, A. and Zinnall, U. and Stoehr, R.
Journal of Cancer 7 (8): 915-920. 7 May 2016

Detecting actively translated open reading frames in ribosome profiling data.
Calviello, L. and Mukherjee, N. and Wyler, E. and Zauber, H. and Hirsekorn, A. and Selbach, M. and Landthaler, M. and Obermayer, B. and Ohler, U.
Nature Methods 13 (2): 165-170. February 2016

2015

A spectral analysis approach to detect actively translated open reading frames in high-resolution ribosome profiling data.
Calviello, L. and Mukherjee, N. and Wyler, E. and Zauber, H. and Hirsekorn, A. and Selbach, M. and Landthaler, M. and Obermayer, B. and Ohler, U.
bioRxiv : 031625. 13 November 2015

Comprehensive protein interactome analysis of a key RNA helicase: detection of novel stress granule proteins.
Bish, R. and Cuevas-Polo, N. and Cheng, Z. and Hambardzumyan, D. and Munschauer, M. and Landthaler, M. and Vogel, C.
Biomolecules 5 (3): 1441-1466. 15 July 2015

RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.
Murakawa, Y. and Hinz, M. and Mothes, J. and Schuetz, A. and Uhl, M. and Wyler, E. and Yasuda, T. and Mastrobuoni, G. and Friedel, C.C. and Dölken, L. and Kempa, S. and Schmidt-Supprian, M. and Blüthgen, N. and Backofen, R. and Heinemann, U. and Wolf, J. and Scheidereit, C. and Landthaler, M.
Nature Communications 6 : 7367. 14 July 2015

LARP4B is an AU-rich sequence associated factor that promotes mRNA accumulation and translation.
Küspert, M. and Murakawa, Y. and Schäffler, K. and Vanselow, J.T. and Wolf, E. and Juranek, S. and Schlosser, A. and Landthaler, M. and Fischer, U.
RNA 21 (7): 1294-1305. July 2015

Regnase-1 and roquin regulate a common element in inflammatory mRNAs by spatiotemporally distinct mechanisms.
Mino, T. and Murakawa, Y. and Fukao, A. and Vandenbon, A. and Wessels, H.H. and Ori, D. and Uehata, T. and Tartey, S. and Akira, S. and Suzuki, Y. and Vinuesa, C.G. and Ohler, U. and Standley, D.M. and Landthaler, M. and Fujiwara, T. and Takeuchi, O.
Cell 161 (5): 1058-1073. 21 May 2015

Quantitative interaction proteomics of neurodegenerative disease proteins.
Hosp, F. and Vossfeldt, H. and Heinig, M. and Vasiljevic, D. and Arumughan, A. and Wyler, E. and Landthaler, M. and Hubner, N. and Wanker, E.E. and Lannfelt, L. and Ingelsson, M. and Lalowski, M. and Voigt, A. and Selbach, M.
Cell Reports 11 (7): 1134-1146. 19 May 2015

DoRiNA 2.0-upgrading the doRiNA database of RNA interactions in post-transcriptional regulation.
Blin, K. and Dieterich, C. and Wurmus, R. and Rajewsky, N. and Landthaler, M. and Akalin, A.
Nucleic Acids Research 43 (Database issue): D160-D167. 28 January 2015

Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals.
Ivanov, A. and Memczak, S. and Wyler, E. and Torti, F. and Porath, H.T. and Orejuela, M.R. and Piechotta, M. and Levanon, E.Y. and Landthaler, M. and Dieterich, C. and Rajewsky, N.
Cell Reports 10 (2): 170-177. 13 January 2015

2014

Roquin binding to target mRNAs involves a winged helix-turn-helix motif.
Schuetz, A. and Murakawa, Y. and Rosenbaum, E. and Landthaler, M. and Heinemann, U.
Nature Communications 5 : 5701. 11 December 2014

A variety of dicer substrates in human and C. elegans.
Rybak-Wolf, A. and Jens, M. and Murakawa, Y. and Herzog, M. and Landthaler, M. and Rajewsky, N.
Cell 159 (5): 1153-1167. 20 November 2014

RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing.
Maatz, H. and Jens, M. and Liss, M. and Schafer, S. and Heinig, M. and Kirchner, M. and Adami, E. and Rintisch, C. and Dauksaite, V. and Radke, M.H. and Selbach, M. and Barton, P.J.R. and Cook, S.A. and Rajewsky, N. and Gotthardt, M. and Landthaler, M. and Hubner, N.
Journal of Clinical Investigation 124 (8): 3419-3430. 1 August 2014

SecA defects are accompanied by dysregulation of MukB, DNA gyrase, chromosome partitioning and DNA superhelicity in Escherichia coli.
Adachi, S. and Murakawa, Y. and Hiraga, S.
Microbiology 160 (Pt 8): 1648-1658. August 2014

MOV10 is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.
Gregersen, L.H. and Schueler, M. and Munschauer, M. and Mastrobuoni, G. and Chen, W. and Kempa, S. and Dieterich, C. and Landthaler, M.
Molecular Cell 54 (4): 573-585. 22 May 2014

PAR-CLIP (photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation): a step-by-step protocol to the transcriptome-wide identification of binding sites of RNA-binding proteins.
Spitzer, J. and Hafner, M. and Landthaler, M. and Ascano, M. and Farazi, T. and Wardle, G. and Nusbaum, J. and Khorshid, M. and Burger, L. and Zavolan, M. and Tuschl, T.
Methods in Enzymology 539 : 113-161. 25 February 2014

High-resolution profiling of protein occupancy on polyadenylated RNA transcripts.
Munschauer, M. and Schueler, M. and Dieterich, C. and Landthaler, M.
Methods 65 (3): 302-309. February 2014

Differential protein occupancy profiling of the mRNA transcriptome.
Schueler, M. and Munschauer, M. and Gregersen, L.H. and Finzel, A. and Loewer, A. and Chen, W. and Landthaler, M. and Dieterich, C.
Genome Biology 15 (1): R15. 13 January 2014

Transcriptome-wide identification of protein binding sites on RNA by PAR-CLIP (photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation).
Hoell, J.I. and Hafner, M. and Landthaler, M. and Ascano, M. and Farazi, T.A. and Wardle, G. and Nusbaum, J. and Cekan, P. and Khorshid, M. and Burger, L. and Zavolan, M. and Tuschl, T.
In: Handbook of RNA Biochemistry: Second, Completely Revised and Enlarged Edition. Wiley-VCH, Weinheim, 877-898. ISBN 9783527327645 2014

2013

Integrative analysis revealed the molecular mechanism underlying RBM10-mediated splicing regulation.
Wang, Y. and Gogol-Döring, A. and Hu, H. and Fröhler, S. and Ma, Y. and Jens, M. and Maaskola, J. and Murakawa, Y. and Quedenau, C. and Landthaler, M. and Kalscheuer, V. and Wieczorek, D. and Wang, Y. and Hu, Y. and Chen, W.
EMBO Molecular Medicine 5 (9): 1431-1442. September 2013

Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation.
Graf, R. and Munschauer, M. and Mastrobuoni, G. and Mayr, F. and Heinemann, U. and Kempa, S. and Rajewsky, N. and Landthaler, M.
RNA Biology 10 (7): 1146-1159. 1 July 2013

An arrayed RNA interference genome-wide screen identifies candidate genes involved in the MicroRNA 21 biogenesis pathway.
Shum, D. and Bhinder, B. and Ramirez, C.N. and Radu, C. and Calder, P.A. and Beauchamp, L. and Farazi, T. and Landthaler, M. and Tuschl, T. and Magdaleno, S. and Djaballah, H.
Assay and Drug Development Technologies 11 (3): 191-205. April 2013

Circular RNAs are a large class of animal RNAs with regulatory potency.
Memczak, S. and Jens, M. and Elefsinioti, A. and Torti, F. and Krueger, J. and Rybak, A. and Maier, L. and Mackowiak, S.D. and Gregersen, L.H. and Munschauer, M. and Loewer, A. and Ziebold, U. and Landthaler, M. and Kocks, C. and le Noble, F. and Rajewsky, N.
Nature 495 (7441): 333-338. 21 March 2013

Cold-induced RNA-binding proteins regulate circadian gene expression by controlling alternative polyadenylation.
Liu, Y. and Hu, W. and Murakawa, Y. and Yin, J. and Wang, G. and Landthaler, M. and Yan, J.
Scientific Reports 3 : 2054. 2013

Rapid creation of stable mammalian cell lines for regulated expression of proteins using the Gateway(R) recombination cloning technology and Flp-In T-REx(R) lines.
Spitzer, J. and Landthaler, M. and Tuschl, T.
Methods in Enzymology 529 : 99-124. 2013

2012

An image-based biosensor assay strategy to screen for modulators of the microRNA 21 biogenesis pathway.
Shum, D. and Bhinder, B. and Radu, C. and Farazi, T. and Landthaler, M. and Tuschl, T. and Calder, P. and Ramirez, C.N. and Djaballah, H.
Combinatorial Chemistry & High Throughput Screening 15 (7): 529-541. August 2012

MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells.
Gregersen, L.H. and Jacobsen, A. and Frankel, L.B. and Wen, J. and Krogh, A. and Lund, A.H.
BMC Cancer 12 : 232. 12 June 2012

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz, A.G. and Munschauer, M. and Schwanhaeusser, B. and Vasile, A. and Murakawa, Y. and Schueler, M. and Youngs, N. and Penfold-Brown, D. and Drew, K. and Milek, M. and Wyler, E. and Bonneau, R. and Selbach, M. and Dieterich, C. and Landthaler, M.
Molecular Cell 46 (5): 674-690. 8 June 2012

Transcriptome-wide analysis of protein-RNA interactions using high-throughput sequencing.
Milek, M. and Wyler, E. and Landthaler, M.
Seminars in Cell & Developmental Biology 23 (2): 206-212. April 2012

doRiNA: a database of RNA interactions in post-transcriptional regulation.
Anders, G. and Mackowiak, S.D. and Jens, M. and Maaskola, J. and Kuntzagk, A. and Rajewsky, N. and Landthaler, M. and Dieterich, C.
Nucleic Acids Research 40 (1): D180-D186. January 2012

2011

Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR.
Lebedeva, S. and Jens, M. and Theil, K. and Schwanhaeusser, B. and Selbach, M. and Landthaler, M. and Rajewsky, N.
Molecular Cell 43 (3): 340-352. 5 August 2011

FOXO1 is an essential regulator of pluripotency in human embryonic stem cells.
Zhang, X. and Yalcin, S. and Lee, D.F. and Yeh, T.Y. and Lee, S.M. and Su, J. and Mungamuri, S.K. and Rimmele, P. and Kennedy, M. and Sellers, R. and Landthaler, M. and Tuschl, T. and Chi, N.W. and Lemischka, I. and Keller, G. and Ghaffari, S.
Nature Cell Biology 13 (9): 1092-1099. 31 July 2011

Fluorescence cross-correlation spectroscopy reveals mechanistic insights into the effect of 2'-O-methyl modified siRNAs in living cells.
Ohrt, T. and Staroske, W. and Muetze, J. and Crell, K. and Landthaler, M. and Schwille, P.
Biophysical Journal 100 (12): 2981-2990. 22 June 2011

2010

Chaperones get RISC loaded.
Landthaler, M.
Molecular Cell 39 (2): 161-162. 30 July 2010

PAR-CliP: a method to identify transcriptome-wide the binding sites of RNA binding proteins.
Hafner, M. and Landthaler, M. and Burger, L. and Khorshid, M. and Hausser, J. and Berninger, P. and Rothballer, A. and Ascano, M. and Jungkamp, A.C. and Munschauer, M. and Ulrich, A. and Wardle, G.S. and Dewell, S. and Zavolan, M. and Tuschl, T.
Journal of Visualized Experiments 41 (2034): e2034. 2 July 2010

Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
Hafner, M. and Landthaler, M. and Burger, L. and Khorshid, M. and Hausser, J. and Berninger, P. and Rothballer, A. and Ascano, M. and Jungkamp, A.C. and Munschauer, M. and Ulrich, A. and Wardle, G.S. and Dewell, S. and Zavolan, M. and Tuschl, T.
Cell 141 (1): 129-141. 2 April 2010

2009

Relative contribution of sequence and structure features to the mRNA binding of Argonaute/EIF2C-miRNA complexes and the degradation of miRNA targets.
Hausser, J. and Landthaler, M. and Jaskiewicz, L. and Gaidatzis, D. and Zavolan, M.
Genome Research 19 (11): 2009-2020. November 2009

Mu opioid receptor knockdown in the substantia nigra/ventral tegmental area by synthetic small interfering RNA blocks the rewarding and locomotor effects of heroin.
Zhang, Y. and Landthaler, M. and Schlussman, S.D. and Yuferov, V. and Ho, A. and Tuschl, T. and Kreek, M.J.
Neuroscience 158 (2): 474-483. 23 January 2009

DGCR8-dependent microRNA biogenesis is essential for skin development.
Yi, R. and Pasolli, H.A. and Landthaler, M. and Hafner, M. and Ojo, T. and Sheridan, R. and Sander, C. and O'Carroll, D. and Stoffel, M. and Tuschl, T. and Fuchs, E.
Proceedings of the National Academy of Sciences of the United States of America 106 (2): 498-502. 13 January 2009

2008

Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs.
Landthaler, M. and Gaidatzis, D. and Rothballer, A. and Chen, P.Y. and Soll, S.J. and Dinic, L. and Ojo, T. and Hafner, M. and Zavolan, M. and Tuschl, T.
RNA 14 (12): 2580-2596. December 2008

2007

Cellular cofactors affecting hepatitis C virus infection and replication.
Randall, G. and Panis, M. and Cooper, J.D. and Tellinghuisen, T.L. and Sukhodolets, K.E. and Pfeffer, S. and Landthaler, M. and Landgraf, P. and Kan, S. and Lindenbach, B.D. and Chien, M. and Weir, D.B. and Russo, J.J. and Ju, J. and Brownstein, M.J. and Sheridan, R. and Sander, C. and Zavolan, M. and Tuschl, T. and Rice, C.M.
Proceedings of the National Academy of Sciences of the United States of America 104 (31): 12884-12889. 31 July 2007

A mammalian microRNA expression atlas based on small RNA library sequencing.
Landgraf, P. and Rusu, M. and Sheridan, R. and Sewer, A. and Iovino, N. and Aravin, A. and Pfeffer, S. and Rice, A. and Kamphorst, A.O. and Landthaler, M. and Lin, C. and Socci, N.D. and Hermida, L. and Fulci, V. and Chiaretti, S. and Foa, R. and Schliwka, J. and Fuchs, U. and Novosel, A. and Mueller, R.U. and Schermer, B. and Bissels, U. and Inman, J. and Phan, Q. and Chien, M. and Weir, D.B. and Choksi, R. and De Vita, G. and Frezzetti, D. and Trompeter, H.I. and Hornung, V. and Teng, G. and Hartmann, G. and Palkovits, M. and Di Lauro, R. and Wernet, P. and Macino, G. and Rogler, C.E. and Nagle, J.W. and Ju, J. and Papavasiliou, F.N. and Benzing, T. and Lichter, P. and Tam, W. and Brownstein, M.J. and Bosio, A. and Borkhardt, A. and Russo, J.J. and Sander, C. and Zavolan, M. and Tuschl, T.
Cell 129 (7): 1401-1414. 29 June 2007

2006

SiRNA-mediated selective inhibition of mutant keratin mRNAs responsible for the skin disorder pachyonychia congenita.
Hickerson, R.P. and Smith, F.J.D. and McLean, W.H.I. and Landthaler, M. and Leube, R.E. and Kaspar, R.L.
Annals of the New York Academy of Sciences 1082 : 56-61. October 2006

I-BasI and I-HmuI: two phage intron-encoded endonucleases with homologous DNA recognition sequences but distinct DNA specificities.
Landthaler, M. and Shen, B.W. and Stoddard, B.L. and Shub, D.A.
Journal of Molecular Biology 358 (4): 1137-1151. 12 May 2006

2005

Identification of novel argonaute-associated proteins.
Meister, G. and Landthaler, M. and Peters, L. and Chen, P.Y. and Urlaub, H. and Luehrmann, R. and Tuschl, T.
Current Biology 15 (23): 2149-2155. 6 December 2005

Retrotransposition strategies of the Lactococcus lactis Ll.LtrB group II intron are dictated by host identity and cellular environment.
Coros, C.J. and Landthaler, M. and Piazza, C.L. and Beauregard, A. and Esposito, D. and Perutka, J. and Lambowitz, A.M. and Belfort, M.
Molecular Microbiology 56 (2): 509-524. April 2005

Endogenous MHC class II processing of a viral nuclear antigen after autophagy.
Paludan, C. and Schmid, D. and Landthaler, M. and Vockerodt, M. and Kube, D. and Tuschl, T. and Muenz, C.
Science 307 (5709): 593-596. 28 January 2005

2004

The human DiGeorge syndrome critical region gene 8 and its D. melanogaster homolog are required for miRNA biogenesis.
Landthaler, M. and Yalcin, A. and Tuschl, T.
Current Biology 14 (23): 2162-2167. 14 December 2004

DNA binding and cleavage by the HNH homing endonuclease I-HmuI.
Shen, B.W. and Landthaler, M. and Shub, D.A. and Stoddard, B.L.
Journal of Molecular Biology 342 (1): 43-56. 3 September 2004

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.
Meister, G. and Landthaler, M. and Patkaniowska, A. and Dorsett, Y. and Teng, G. and Tuschl, T.
Molecular Cell 15 (2): 185-197. 23 July 2004

Group I intron homing in Bacillus phages SPO1 and SP82: a gene conversion event initiated by a nicking homing endonuclease.
Landthaler, M. and Lau, N.C. and Shub, D.A.
Journal of Bacteriology 186 (13): 4307-4314. July 2004

Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing.
Meister, G. and Landthaler, M. and Dorsett, Y. and Tuschl, T.
RNA 10 (3): 544-550. March 2004

2003

The nicking homing endonuclease I-BasI is encoded by a group I intron in the DNA polymerase gene of the Bacillus thuringiensis phage Bastille.
Landthaler, M. and Shub, D.A.
Nucleic Acids Research 31 (12): 3071-3077. 15 June 2003

2002

Intronless homing: site-specific endonuclease SegF of bacteriophage T4 mediates localized marker exclusion analogous to homing endonucleases of group I introns.
Belle, A. and Landthaler, M. and Shub, D.A.
Genes & Development 16 (3): 351-362. 2002

Two self-splicing group I introns in the ribonucleotide reductase large subunit gene of Staphylococcus aureus phage Twort.
Landthaler, M. and Begley, U. and Lau, N.C. and Shub, D.A.
Nucleic Acids Research 30 (9): 1935-1943. 2002

1999

Unexpected abundance of self-splicing introns in the genome of bacteriophage Twort: introns in multiple genes, a single gene with three introns, and exon skipping by group I ribozymes.
Landthaler, M. and Shub, D.A.
Proceedings of the National Academy of Sciences of the United States of America 96 (12): 7005-7010. 8 June 1999