Browse by Research Team

2009

Applying a "double-feature" promoter to identify cardiomyocytes differentiated from human embryonic stem cells following transposon-based gene delivery.
Orban, T.I., Apati, A., Nemeth, A., Varga, N., Krizsik, V., Schamberger, A., Szebenyi, K., Erdei, Z., Varady, G., Karaszi, E., Homolya, L., Nemet, K., Gocza, E., Miskey, C., Mates, L., Ivics, Z., Izsvak, Z. and Sarkadi, B.
Stem Cells 27 (5): 1077-1087. 20 February 2009

Interactions of transposons with the cellular DNA repair machinery.
Izsvak, Z., Wang, Y. and Ivics, Z.
Genome Dynamics and Stability 4 : 133-176. 2009

2008

Targeted gene insertion for molecular medicine.
Voigt, K., Izsvak, Z. and Ivics, Z.
Journal of Molecular Medicine 86 (11): 1205-1219. November 2008

Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes.
Sinzelle, L., Kapitonov, V.V., Grzela, D.P., Jursch, T., Jurka, J., Izsvak, Z. and Ivics, Z.
Proceedings of the National Academy of Sciences of the United States of America 105 (12): 4715-4720. 25 March 2008

Transcriptional activities of the Sleeping Beauty transposon and shielding its genetic cargo with insulators.
Walisko, O., Schorn, A., Rolfs, F., Devaraj, A., Miskey, C., Izsvak, Z. and Ivics, Z.
Molecular Therapy 16 (2): 359-369. February 2008

Insertional mutagenesis of the mouse germline with Sleeping Beauty transposition.
Takeda, J., Izsvak, Z. and Ivics, Z.
Methods in Molecular Biology 435 : 109-125. 2008

2007

Technology transfer from worms and flies to vertebrates: transposition-based genome manipulations and their future perspectives.
Mates, L., Izsvak, Z. and Ivics, Z.
Genome Biology 8 Suppl 1 : S1. 31 October 2007

The Ancient Mariner Sails Again: Transposition of the Human Hsmar1 Element by a Reconstructed Transposase and Activities of the SETMAR Protein on Transposon Ends.
Miskey, C., Papp, B., Mates, L., Sinzelle, L., Keller, H., Izsvak, Z. and Ivics, Z.
Molecular and Cellular Biology 27 (12): 4589-4600. 15 June 2007

Targeted Sleeping Beauty transposition in human cells.
Ivics, Z., Katzer, A., Stuewe, E.E., Fiedler, D., Knespel, S. and Izsvak, Z.
Molecular Therapy 15 (6): 1137-1144. June 2007

2006

Reconstructed human mariner transposon capable of stable gene transfer into chromosomes in vertebrates [Rekonstruktion eines menschlichen Mariner Transposons, das zum stabilen Gentransfer in Chromosome von Wirbeltieren geeignet ist].
Miskey, C. and Ivics, Z.
EP1710316 ; >WO06108525. 11 October 2006

Transposons for gene therapy!
Ivics, Z. and Izsvak, Z.
Current Gene Therapy 6 (5): 593-607. October 2006

Hungary's 'reforms' are threatening basic science.
Izsvak, Z., Ivics, Z. and Mates, L.
Nature 443 (7110): 394. 28 September 2006

Interference with cell cycle progression by parasitic genetic elements: Sleeping Beauty joins the club.
Walisko, O. and Ivics, Z.
Cell Cycle 5 (12): 1275-1280. June 2006

Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1.
Walisko, O., Izsvak, Z., Szabo, K., Kaufman, C.D., Herold, S. and Ivics, Z.
Proceedings of the National Academy of Sciences of the United States of America 103 (11): 4062-4067. 14 March 2006

Transposons.
Ivics, Z., Walisko, O. and Izsvak, Z.
In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2. Springer, Berlin [u.a.], 1915-1919. ISBN 3-540-44244-8 2006

2005

Transposon-based targeting system [Transposon-System zur gezielten Integration].
Ivics, Z. and Izsvak, Z.
EP1594971 ; EP1594972 ; EP1594973 ; WO0469994 ; WO0469995 ; WO0470042. 16 November 2005

Frog Prince transposon-based RNAi vectors mediate efficient gene knockdown in human cells.
Kaufman, C.D., Izsvak, Z., Katzer, A. and Ivics, Z.
Journal of RNAi and Gene Silencing 1 (2): 97-104. October 2005

Sleeping Beauty hits them all: transposon-mediated saturation mutagenesis in the mouse germline.
Izsvak, Z. and Ivics, Z.
Nature Methods 2 (10): 735-736. October 2005

DNA transposons in vertebrate functional genomics.
Miskey, C., Izsvak, Z., Kawakami, K. and Ivics, Z.
Cellular and Molecular Life Sciences 62 (6): 629-641. March 2005

A whole lotta jumpin' goin' on: new transposon tools for vertebrate functional genomics.
Ivics, Z. and Izsvak, Z.
Trends in Genetics 21 (1): 8-11. 1 January 2005

2004

Development of hyperactive Sleeping Beauty transposon vectors by mutational analysis.
Zayed, H., Izsvak, Z., Walisko, O. and Ivics, Z.
Molecular Therapy 9 (2): 292-304. 1 February 2004

Sleeping Beauty transposition: biology and applications for molecular therapy.
Izsvak, Z. and Ivics, Z.
Molecular Therapy 9 (2): 147-156. 1 February 2004

Healing the wounds inflicted by Sleeping Beauty transposition by double-strand break repair in mammalian somatic cells.
Izsvak, Z., Stuewe, E.E., Fiedler, D., Katzer, A., Jeggo, P.A. and Ivics, Z.
Molecular Cell 13 (2): 279-290. 1 January 2004

The Sleeping Beauty transposable element: evolution, regulation and genetic applications.
Ivics, Z., Kaufman, C.D., Zayed, H., Miskey, C., Walisko, O. and Izsvak, Z.
Current Issues in Molecular Biology 6 (1): 43-55. 1 January 2004

Transposable elements for transgenesis and insertional mutagenesis in vertebrates: a contemporary review of experimental strategies.
Ivics, Z. and Izsvak, Z.
In: Mobile Genetic Elements: Protocols and Genomic Applications. Methods in Molecular Biology ; 260, 260 . Humana Press, Totowa, NJ, 255-276. ISBN 1-58829-007-7 1 January 2004

2003

Frog Prince, ein Transposonvektor fuer den Gentransfer bei Wirbeltieren [The Frog Prince, a transposon vector for gene transfer in vertebrates].
Miskey, C., Izsvak, Z. and Ivics, Z.
DE10224242A1 ; EP1507865 ; WO03100070. 11 December 2003

The Frog Prince: a reconstructed transposon from Rana pipiens with high transpositional activity in vertebrate cells.
Miskey, C., Izsvak, Z., Plasterk, R.H. and Ivics, Z.
Nucleic Acids Research 31 (23): 6873-6881. 1 December 2003

The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition.
Zayed, H., Izsvak, Z., Khare, D., Heinemann, U. and Ivics, Z.
Nucleic Acids Research 31 (9): 2313-2322. 1 May 2003

2002

Common physical properties of DNA affecting target site selection of Sleeping Beauty and other Tc1/mariner transposable elements.
Vigdal, T.J., Kaufman, C.D., Izsvak, Z., Voytas, D.F. and Ivics, Z.
Journal of Molecular Biology 323 (3): 441-452. 25 October 2002

Involvement of a bifunctional, paired-like DNA-binding domain and a transpositional enhancer in Sleeping Beauty transposition.
Izsvak, Z., Khare, D., Behlke, J., Heinemann, U., Plasterk, R.H. and Ivics, Z.
Journal of Biological Chemistry 277 (37): 34581-34588. 13 September 2002

Structure-function analysis of the inverted terminal repeats of the Sleeping Beauty transposon.
Cui, Z., Geurts, A.M., Liu, G., Kaufman, C.D. and Hackett, P.B.
Journal of Molecular Biology 318 (5): 1221-1235. 17 May 2002

2001

Sleeping Beauty, ein Transposonvektor mit breitem Wirtsbereich fuer die genetische Transformation bei Wirbeltieren.
Ivics, Z. and Izsvak, Z.
DE10120829A1 ; EP1276889 ; WO0181565. 20 December 2001

Inhibition of skiA and skiB gene expression ventralizes zebrafish embryos.
Cui, Z., Clark, K.J., Kaufman, C.D. and Hackett, P.B.
Genesis 30 : 149-153. 1 July 2001

Cloning and expression of sprint, a Drosophila homologue of RIN1.
Szabo, K., Jekely, G. and Rorth, P.
Mechanisms of Development 101 : 259-262. 1 March 2001

2000

Sleeping Beauty, a wide host-range transposon vector for genetic transformation in vertebrates.
Izsvak, Z., Ivics, Z. and Plasterk, R.H.
Journal of Molecular Biology 302 : 93-102. 8 September 2000

Ectopic expression of c-ski disrupts gastrulation and neural patterning in zebrafish.
Kaufman, C.D., Martinez-Rodriguez, G. and Hackett, P.B.
Mechanisms of Development 95 : 147-162. 1 July 2000

The level of C/EBP protein is critical for cell migration during Drosophila oogenesis and is tightly controlled by regulated degradation.
Rorth, P., Szabo, K. and Texido, G.
Molecular Cell 6 : 23-30. 1 July 2000

Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system.
Yant, S.R., Meuse, L., Chiu, W., Ivics, Z., Izsvak, Z. and Kay, M.A.
Nature Genetics 25 (1): 35-41. 1 May 2000

1999

Resident aliens: the Tc1/mariner superfamily of transposable elements.
Plasterk, R.H., Izsvak, Z. and Ivics, Z.
Trends in Genetics 15 : 326-332. 1 August 1999

Nucleic acid transfer vector for the introduction of nucleic acid into the DNA of a cell.
Hackett, B.P., Clark, J.K., Dupuy, J.A., Ekker, C.S., Largaespada, A.D., Ivics, Z. and Izsvak, Z.
EP1034258 ; WO9925817. 27 May 1999

Development of genetic tools for transgenic animals.
Hackett, P.B., Izsvak, Z., Ivics, Z. and Caldovic, L.
In: Transgenic Animals in Agriculture. CAB International, Wallingford, UK, 19-35. ISBN 9780851992938 1 January 1999

Genetic applications of transposons and other repetitive elements in zebrafish.
Ivics, Z., Izsvak, Z. and Hackett, P.B.
Methods in Cell Biology 60 : 99-131. 1 January 1999

Short inverted-repeat transposable elements in teleost fish and implications for a mechanism of their amplification.
Izsvak, Z., Ivics, Z., Shimoda, N., Mohn, D., Okamoto, H. and Hackett, P.B.
Journal of Molecular Evolution 48 : 13-21. 1 January 1999

1998

Elements transposables: des outils permettant la mutagenese et le transgenese chez les vertebres [Transposable elements as tools from mutagenesis and transgenesis of vertebrates].
Plasterk, R.H., Van Luenen, H., Vos, C., Ivics, Z., Izsvak, Z. and Fischer, S.
Pathologie Biologie 46 : 674-675. 1 November 1998

DNA-based transposon system for the introduction of nucleic acid into DNA of a cell [DNS-basiertes Transposon-System fuer die Einfuehrung von Nucleinsaeure in die DNS einer Zelle].
Hackett, B.P., Ivics, Z. and Izsvak, Z.
EP0973928 ; WO9840510. 17 September 1998

Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells.
Luo, G., Ivics, Z., Izsvak, Z. and Bradley, A.
Proceedings of the National Academy of Sciences of the United States of America 95 (18): 10769-10773. 1 September 1998

Systematic gain-of-function genetics in Drosophila.
Rørth, P., Szabo, K., Bailey, A., Laverty, T., Rehm, J., Rubin, G.M., Weigmann, K., Milan, M., Benes, V., Ansorge, W. and Cohen, S.M.
Development 125 (6): 1049-1057. 1 March 1998

1997

Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells.
Ivics, Z., Hackett, P.B., Plasterk, R.H. and Izsvak, Z.
Cell 91 (4): 501-510. 14 November 1997

Repetitive elements and their genetic applications in zebrafish.
Izsvak, Z., Ivics, Z. and Hackett, P.B.
Biochemistry and Cell Biology 75 (5): 507-523. 1 October 1997

Cloning and characterization of the genes of the CeqI restriction-modification system.
Izsvak, Z., Jobbagy, Z., Takacs, I. and Duda, E.
International Journal of Biochemistry and Cell Biology 29 : 895-900. 1 June 1997

Family of plasmid vectors for the expression of beta-galactosidase fusion proteins in eukaryotic cells.
Ivics, Z. and Izsvak, Z.
Biotechniques 22 : 254-258. 1 February 1997

1996

Identification of functional domains and evolution of Tc1-like transposable elements.
Ivics, Z., Izsvak, Z., Minter, A. and Hackett, P.B.
Proceedings of the National Academy of Sciences of the United States of America 93 (10): 5008-5013. 14 May 1996

DANA elements: a family of composite, tRNA-derived short interspersed DNA elements associated with mutational activities in zebrafish (Danio rerio).
Izsvak, Z., Ivics, Z., Garcia-Estefania, D., Fahrenkrug, S.C. and Hackett, P.B.
Proceedings of the National Academy of Sciences of the United States of America 93 (3): 1077-1081. 6 February 1996

1995

Characterization of a Tc1-like transposable element in zebrafish (Danio rerio).
Izsvak, Z., Ivics, Z. and Hackett, P.B.
Molecular and General Genetics 247 (3): 312-322. 10 May 1995

Repeated sequence elements in zebrafish and their use in molecular genetic studies (Minireview).
Ivics, Z., Izsvak, Z. and Hackett, P.B.
Zebrafish Science Monitor 3 : 1-4. 1 January 1995

1993

Two-stage ligation-mediated PCR enhances the detection of integrated transgenic DNA.
Izsvak, Z. and Ivics, Z.
Biotechniques 15, 5 : 814-818. 1 November 1993

Enhanced incorporation of transgenic DNA into zebrafish chromosomes by a retroviral integration protein.
Ivics, Z., Izsvak, Z. and Hackett, P.B.
Molecular Marine Biology and Biotechnology 2 (3): 162-173. June 1993

1992

Purification and characterization of CeqI restriction endonuclease.
Izsvak, Z., Jobbagy, Z. and Duda, E.
Zeitschrift fuer Naturforschung C, A Journal of Biosciences 47 : 830-834. 1 November 1992

Positive co-operative interaction between the subunits of CeqI restriction endonuclease.
Jobbagy, Z., Izsvak, Z. and Duda, E.
Biochemical Journal 286 : 85-88. 15 August 1992

Introducing foreign genes into fish eggs with electroporated sperm as a carrier.
Mueller, F., Ivics, Z., Erdelyi, F., Papp, T., Varadi, L., Horvath, L. and Maclean, N.
Molecular Marine Biology and Biotechnology 1 : 276-281. 1 August 1992