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Article

Cell states in cancer: drivers, passengers, and trailers.
Gargiulo, G. and Serresi, M. and Marine, J.C.
Cancer Discovery 14 (4): 610-614. 4 April 2024

Clonal dominance defines metastatic dissemination in pancreatic cancer.
Ho, I.L. and Li, C.Y. and Wang, F. and Zhao, L. and Liu, J. and Yen, E.Y. and Dyke, C.A. and Shah, R. and Liu, Z. and Çetin, A.O. and Chu, Y. and Citron, F. and Attanasio, S. and Corti, D. and Darbaniyan, F. and Del Poggetto, E. and Loponte, S. and Liu, J. and Soeung, M. and Chen, Z. and Jiang, S. and Jiang, H. and Inoue, A. and Gao, S. and Deem, A. and Feng, N. and Ying, H. and Kim, M. and Giuliani, V. and Genovese, G. and Zhang, J. and Futreal, A. and Maitra, A. and Heffernan, T. and Wang, L. and Do, K.A. and Gargiulo, G. and Draetta, G. and Carugo, A. and Lin, R. and Viale, A.
Science Advances 10 (11): eadd9342. 15 March 2024

Logical design of synthetic cis-regulatory DNA for genetic tracing of cell identities and state changes.
Company, C. and Schmitt, M.J. and Dramaretska, Y. and Serresi, M. and Kertalli, S. and Jiang, B. and Yin, J.A. and Aguzzi, A. and Barozzi, I. and Gargiulo, G.
Nature Communications 15 (1): 897. 5 February 2024

Pharmacological modulators of epithelial immunity uncovered by synthetic genetic tracing of SARS-CoV-2 infection responses.
Jiang, B. and Schmitt, M.J. and Rand, U. and Company, C. and Dramaretska, Y. and Grossmann, M. and Serresi, M. and Cicin-Sain, L. and Gargiulo, G.
Science Advances 9 (25): eadf4975. 23 June 2023

Molecular identity of proprioceptor subtypes innervating different muscle groups in mice.
Dietrich, S. and Company, C. and Song, K. and Lowenstein, E.D. and Riedel, L. and Birchmeier, C. and Gargiulo, G. and Zampieri, N.
Nature Communications 13 (1): 6867. 11 November 2022

Optimization of synthetic molecular reporters for a mesenchymal glioblastoma transcriptional program by integer programming.
Breitenbach, T. and Schmitt, M.J. and Dandekar, T.
Bioinformatics 38 (17): 4162-4171. 1 September 2022

Cannabidiol converts NF(κ)B into a tumor suppressor in glioblastoma with defined antioxidative properties.
Volmar, M.N.M. and Cheng, J. and Alenezi, H. and Richter, S. and Haug, A. and Hassan, Z. and Goldberg, M. and Li, Y. and Hou, M. and Herold-Mende, C. and Maire, C.L. and Lamszus, K. and Flüh, C. and Held-Feindt, J. and Gargiulo, G. and Topping, G.J. and Schilling, F. and Saur, D. and Schneider, G. and Synowitz, M. and Schick, J.A. and Kälin, R.E. and Glass, R.
Neuro-Oncology 23 (11): 1898-1910. November 2021

NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1.
Marques, C. and Unterkircher, T. and Kroon, P. and Oldrini, B. and Izzo, A. and Dramaretska, Y. and Ferrarese, R. and Kling, E. and Schnell, O. and Nelander, S. and Wagner, E.F. and Bakiri, L. and Gargiulo, G. and Carro, M.S. and Squatrito, M.
eLife 10 : e64846. 17 August 2021

HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness.
Ho, J.S. and Di Tullio, F. and Schwarz, M. and Low, D. and Incarnato, D. and Gay, F. and Tabaglio, T. and Zhang, J.X. and Wollmann, H. and Chen, L. and An, O. and Chan, T.H.M. and Hall Hickman, A. and Zheng, S. and Roudko, V. and Chen, S. and Karz, A. and Ahmed, M. and He, H.H. and Greenbaum, B.D. and Oliviero, S. and Serresi, M. and Gargiulo, G. and Mann, K.M. and Hernando, E. and Mulholland, D. and Marazzi, I. and Wee, D.K.B. and Guccione, E.
eLife 10 : e59654. 2 June 2021

Phenotypic mapping of pathologic cross-talk between glioblastoma and innate immune cells by synthetic genetic tracing.
Schmitt, M.J. and Company, C. and Dramaretska, Y. and Barozzi, I. and Göhrig, A. and Kertalli, S. and Großmann, M. and Naumann, H. and Sánchez-Bailón, M.P. and Hulsman, D. and Glass, R. and Squatrito, M. and Serresi, M. and Gargiulo, G.
Cancer Discovery 11 (3): 754-777. March 2021

Functional antagonism of chromatin modulators regulates epithelial-mesenchymal transition.
Serresi, M. and Kertalli, S. and Li, L. and Schmitt, M.J. and Dramaretska, Y. and Wierikx, J. and Hulsman, D. and Gargiulo, G.
Science Advances 7 (9): eabd7974. 24 February 2021

The relevance of the SH2 domain for c-Src functionality in triple-negative breast cancer cells.
Mayoral-Varo, V. and Sánchez-Bailón, M.P. and Calcabrini, A. and García-Hernández, M. and Frezza, V. and Martín, M.E. and González, V.M. and Martín-Pérez, J.
Cancers 13 (3): 462. 26 January 2021

USP15 deubiquitinase safeguards hematopoiesis and genome integrity in hematopoietic stem cells and leukemia cells.
van den Berk, P. and Lancini, C. and Company, C. and Serresi, M. and Sanchez-Bailon, M.P. and Hulsman, D. and Pritchard, C. and Song, J.Y. and Schmitt, M.J. and Tanger, E. and Popp, O. and Mertins, P. and Huijbers, I.J. and Jacobs, H. and van Lohuizen, M. and Gargiulo, G. and Citterio, E.
Cell Reports 33 (13): 108533. 29 December 2020

Targeting APLN/APLNR improves antiangiogenic efficiency and blunts proinvasive side effects of VEGFA/VEGFR2 blockade in glioblastoma.
Mastrella, G. and Hou, M. and Li, M. and Stoecklein, V.M. and Zdouc, N. and Volmar, M.N.M. and Miletic, H. and Reinhard, S. and Herold-Mende, C.C. and Kleber, S. and Eisenhut, K. and Gargiulo, G. and Synowitz, M. and Vescovi, A.L. and Harter, P.N. and Penninger, J.M. and Wagner, E. and Mittelbronn, M. and Bjerkvig, R. and Hambardzumyan, D. and Schüller, U. and Tonn, J.C. and Radke, J. and Glass, R. and Kälin, R.E.
Cancer Research 79 (9): 2298-2313. May 2019

Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities.
Serresi, M. and Siteur, B. and Hulsman, D. and Company, C. and Schmitt, M.J. and Lieftink, C. and Morris, B. and Cesaroni, M. and Proost, N. and Beijersbergen, R.L. and van Lohuizen, M. and Gargiulo, G.
Journal of Experimental Medicine 215 (12): 3115. 3 December 2018

SOX2 is the determining oncogenic switch in promoting lung squamous cell carcinoma from different cells of origin.
Ferone, G. and Song, J.Y. and Sutherland, K.D. and Bhaskaran, R. and Monkhorst, K. and Lambooij, J.P. and Proost, N. and Gargiulo, G. and Berns, A.
Cancer Cell 30 (4): 519-532. 10 October 2016

Polycomb and lung cancer: when the dosage makes the (kind of) poison.
Gargiulo, G. and Citterio, E. and Serresi, M.
Molecular & Cellular Oncology 3 (3): e1152345. May 2016

Polycomb repressive complex 2 is a barrier to KRAS-driven inflammation and epithelial-mesenchymal transition in non-small-cell lung cancer.
Serresi, M. and Gargiulo, G. and Proost, N. and Siteur, B. and Cesaroni, M. and Koppens, M. and Xie, H. and Sutherland, K.D. and Hulsman, D. and Citterio, E. and Orkin, S. and Berns, A. and van Lohuizen, M.
Cancer Cell 29 (1): 17-31. 11 January 2016

In vivo shRNA screens in solid tumors.
Gargiulo, G. and Serresi, M. and Cesaroni, M. and Hulsman, D. and van Lohuizen, M.
Nature Protocols 9 (12): 2880-2902. December 2014

Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.
Lancini, C. and van den Berk, P.C.M. and Vissers, J.H.A. and Gargiulo, G. and Song, J.Y. and Hulsman, D. and Serresi, M. and Tanger, E. and Blom, M. and Vens, C. and van Lohuizen, M. and Jacobs, H. and Citterio, E.
Journal of Experimental Medicine 211 (9): 1759-1777. 25 August 2014

The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation.
Sparmann, A. and Xie, Y. and Verhoeven, E. and Vermeulen, M. and Lancini, C. and Gargiulo, G. and Hulsman, D. and Mann, M. and Knoblich, J.A. and van Lohuizen, M.
EMBO Journal 32 (11): 1598-1612. 29 May 2013

In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis.
Gargiulo, G. and Cesaroni, M. and Serresi, M. and de Vries, N. and Hulsman, D. and Bruggeman, S.W. and Lancini, C. and van Lohuizen, M.
Cancer Cell 23 (5): 660-676. 13 May 2013

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer.
Di Micco, R. and Sulli, G. and Dobreva, M. and Liontos, M. and Botrugno, O.A. and Gargiulo, G. and dal Zuffu, R. and Matti, V. and d'Ario, G. and Montani, E. and Mercurio, C. and Hahn, W.C. and Gorgoulis, V. and Minucci, S. and d'Adda di Fagagna, F.
Nature Cell Biology 13 (3): 292-302. March 2011

NA-Seq: a discovery tool for the analysis of chromatin structure and dynamics during differentiation.
Gargiulo, G. and Levy, S. and Bucci, G. and Romanenghi, M. and Fornasari, L. and Beeson, K.Y. and Goldberg, S.M. and Cesaroni, M. and Ballarini, M. and Santoro, F. and Bezman, N. and Frige, G. and Gregory, P.D. and Holmes, M.C. and Strausberg, R.L. and Pelicci, P.G. and Urnov, F.D. and Minucci, S.
Developmental Cell 16 (3): 466-481. 17 March 2009

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.
Bracken, A.P. and Kleine-Kohlbrecher, D. and Dietrich, N. and Pasini, D. and Gargiulo, G. and Beekman, C. and Theilgaard-Moench, K. and Minucci, S. and Porse, B.T. and Marine, J.-C. and Hansen, K.H. and Helin, K.
Genes & Development 21 (5): 525-530. 1 March 2007

Review

Next-generation in vivo modeling of human cancers.
Gargiulo, G.
Frontiers in Oncology 8 : 429. October 2018

Epigenomic profiling of cancer cells.
Gargiulo, G. and Minucci, S.
International Journal of Biochemistry and Cell Biology 41 (1): 127-135. January 2009

Preprint

HNRNPM controls circRNA biogenesis and splicing fidelity to sustain prostate cancer cell fitness.
Ho, J.S.Y. and Low, D. and Schwarz, M. and Incarnato, D. and Gay, F. and Tabaglio, T. and Zhang, J. and Wollman, H. and Chen, L. and An, O. and Chan, T.H.M. and Hickman, A.H. and Zheng, S. and Roudko, V. and Chen, S. and Ahmed, M. and He, H.H. and Greenbaum, B.D. and Marazzi, I. and Serresi, M. and Gargiulo, G. and Oliviero, S. and Wee, D.K.B. and Guccione, E.
bioRxiv : 2020.06.17.157537. 18 June 2020

USP15 deubiquitinase safeguards hematopoiesis and genome integrity in hematopoietic stem cells and leukemia cells.
van den Berk, P. and Lancini, C. and Company, C. and Serresi, M. and Hulsman, D. and Pritchard, C. and Song, J.Y. and Schmitt, M.J. and Tanger, E. and Huijbers, I.J. and Jacobs, H. and van Lohuizen, M. and Gargiulo, G. and Citterio, E.
bioRxiv : 2020.01.23.916627. 24 January 2020

NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1.
Marques, C. and Unterkircher, T. and Kroon, P. and Izzo, A. and Gargiulo, G. and Kling, E. and Schnell, O. and Nelander, S. and Wagner, E.F. and Bakiri, L. and Carro, M.S. and Squatrito, M.
bioRxiv : 834531. 7 November 2019