Browse by Research Team

2024

Characterization of two iPSC lines from patients with maternally inherited leigh (MILS) and neuropathy, ataxia, and retinitis pigmentosa (NARP) syndrome carrying the MT-ATP6 m.8993 T>G mutation at different degrees of heteroplasmy.
Haschke, A.M., Diecke, S. and Schuelke, M.
Stem Cell Research 81 : 103547. December 2024

Generation of two isogenic human iPSC lines (ZIPi013-B-1, ZIPi013-B-2) carrying a CRISPR/Cas9-mediated deletion of TRPM4.
Haferkamp, U., Telugu, N., Krieg, K., Schaefer, W., Lam, D., Binkle-Ladisch, L., Friese, M.A., Diecke, S. and Pless, O.
Stem Cell Research 81 : 103609. December 2024

Reassessment of marker genes in human induced pluripotent stem cells for enhanced quality control.
Dobner, J., Diecke, S., Krutmann, J., Prigione, A. and Rossi, A.
Nature Communications 15 (1): 8547. 2 October 2024

Evolution of translational control and the emergence of genes and open reading frames in human and non-human primate hearts.
Ruiz-Orera, J., Miller, D.C., Greiner, J., Genehr, C., Grammatikaki, A., Blachut, S., Mbebi, J., Patone, G., Myronova, A., Adami, E., Dewani, N., Liang, N., Hummel, O., Mücke, M.B., Hildebrandt, T.B., Fritsch, G., Schrade, L., Zimmermann, W.H., Kondova, I., Diecke, S., van Heesch, S. and Hübner, N.
Nature Cardiovascular Research 3 (10): 1217-1235. October 2024

Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure.
Lisowski, P., Lickfett, S., Rybak-Wolf, A., Menacho, C., Le, S., Pentimalli, T.M., Notopoulou, S., Dykstra, W., Oehler, D., López-Calcerrada, S., Mlody, B., Otto, M., Wu, H., Richter, Y., Roth, P., Anand, R., Kulka, L.A.M., Meierhofer, D., Glazar, P., Legnini, I., Telugu, N.S., Hahn, T., Neuendorf, N., Miller, D.C., Böddrich, A., Polzin, A., Mayatepek, E., Diecke, S., Olzscha, H., Kirstein, J., Ugalde, C., Petrakis, S., Cambridge, S., Rajewsky, N., Kühn, R., Wanker, E.E., Priller, J., Metzger, J.J. and Prigione, A.
Nature Communications 15 (1): 7027. 22 August 2024

Interaction of sortilin with apolipoprotein E3 enables neurons to use long-chain fatty acids as alternative metabolic fuel.
Greda, A.K., Gomes, J.P., Zurawska-Plaksej, E., Fritsche-Guenther, R., Rudolph, I.M., Telugu, N.S., Cömert, C., Kirwan, J., Kunz, S., Rothe, M., Diecke, S., Bross, P. and Willnow, T.E.
bioRxiv : 2024.06.10.598173. 10 June 2024

A standardized nomenclature design for systematic referencing and identification of animal cellular material.
Schrade, L., Mah, N., Bandrowski, A., Chen, Y., Dewender, J., Diecke, S., Hiepen, C., Lancaster, M.A., Marques-Bonet, T., Martinez, S., Mueller, S.C., Navara, C., Prigione, A., Seltmann, S., Sochacki, J., Sutcliffe, M.A., Zywitza, V., Hildebrandt, T.B. and Kurtz, A.
Animals 14 (11): 1541. 1 June 2024

The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions.
Fasciani, I., Petragnano, F., Wang, Z., Edwards, R., Telugu, N., Pietrantoni, I., Zabel, U., Zauber, H., Grieben, M., Terzenidou, M.E., Di Gregorio, J., Pellegrini, C., Santini, S., Taddei, A.R., Pohl, B., Aringhieri, S., Carli, M., Aloisi, G., Marampon, F., Charlesworth, E., Roman, A., Diecke, S., Flati, V., Giorgi, F., Amicarelli, F., Tobin, A.B., Scarselli, M., Tokatlidis, K., Rossi, M., Lohse, M.J., Annibale, P. and Maggio, R.
PLoS Biology 22 (4): e3002582. 29 April 2024

SRRM2 splicing factor modulates cell fate in early development.
Carvalho, S., Zea-Redondo, L., Tang, T.C.C., Stachel-Braum, P., Miller, D., Caldas, P., Kukalev, A., Diecke, S., Grosswendt, S., Grosso, A.R. and Pombo, A.
Biology Open 13 (4): bio060415. April 2024

2023

Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells.
Urzi, A., Lahmann, I., Nguyen, L.V.N., Rost, B.R., García-Pérez, A., Lelievre, N., Merritt-Garza, M.E., Phan, H.C, Bassell, G.J., Rossoll, W., Diecke, S., Kunz, S., Schmitz, D. and Gouti, M.
Nature Communications 14 (1): 8043. 19 December 2023

Generation of an NCS1 gene knockout human induced pluripotent stem cell line using CRISPR/Cas9.
Maierhof, S.K., Schinke, C., Cernoch, J., Hew, L., Bruske, L.P., Fernandez Vallone, V., Fischer, K., Stachelscheid, H., Huehnchen, P., Endres, M., Diecke, S., Telugu, N.S. and Boehmerle, W.
Stem Cell Research 73 : 103253. December 2023

Neurofibromin 1 mutations impair the function of human induced pluripotent stem cell-derived microglia.
Kuhrt, L.D., Motta, E., Elmadany, N., Weidling, H., Fritsche-Guenther, R., Efe, I.E., Cobb, O., Chatterjee, J., Boggs, L.G., Schnauß, M., Diecke, S., Semtner, M., Anastasaki, C., Gutmann, D.H. and Kettenmann, H.
Disease Models & Mechanisms 16 (12): dmm049861. December 2023

In vitro fertilization program in white rhinoceros.
Hildebrandt, T.B., Holtze, S., Colleoni, S., Hermes, R., Stejskal, J., Lekolool, I., Ndereeh, D., Omondi, P., Kariuki, L., Mijele, D., Mutisya, S., Ngulu, S., Diecke, S., Hayashi, K., Lazzari, G., de Mori, B., Biasetti, P., Quaggio, A., Galli, C. and Goeritz, F.
Reproduction 166 (6): 383-399. 25 October 2023

Phosphatidylinositol 3,5-bisphosphate facilitates axonal vesicle transport and presynapse assembly.
Rizalar, F.S., Lucht, M.T., Petzoldt, A., Kong, S., Sun, J., Vines, J.H., Telugu, N.S., Diecke, S., Kaas, T., Bullmann, T., Schmied, C., Löwe, D., King, J.S., Cho, W., Hallermann, S., Puchkov, D., Sigrist, S.J. and Haucke, V.
Science 382 (6667): 223-230. 12 October 2023

ASSURED-optimized CRISPR protocol for knockout/SNP knockin in hiPSCs.
Ludwik, K.A., Telugu, N., Schommer, S., Stachelscheid, H. and Diecke, S.
STAR Protocols 4 (3): 102406. 15 September 2023

A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals.
Lázaro, J., Costanzo, M., Sanaki-Matsumiya, M., Girardot, C., Hayashi, M., Hayashi, K., Diecke, S., Hildebrandt, T.B., Lazzari, G., Wu, J., Petkov, S., Behr, R., Trivedi, V., Matsuda, M. and Ebisuya, M.
Cell Stem Cell 30 (7): 938-949.e7. 6 July 2023

iPSC-derived reactive astrocytes from patients with multiple-sclerosis protect cocultured neurons in inflammatory conditions.
Kerkering, J., Muinjonov, B., Rosiewicz, K.S., Diecke, S., Biese, C., Schiweck, J., Chien, C., Zocholl, D., Conrad, T., Paul, F., Alisch, M. and Siffrin, V.
Journal of Clinical Investigation 133 (13): e164637. 3 July 2023

Assessment of pre-clinical liver models based on their ability to predict the liver-tropism of adeno-associated virus vectors.
Westhaus, A., Cabanes Creus, M., Dilworth, K.L., Zhu, E., Salas, D., Navarro, R.G., Amaya, A.K., Scott, A., Kwiatek, M., McCorkindale, A.L., Hayman, T.E., Frahm, A., Perocheau, D., Tran, B.M., Vincan, E., Wong, S.L., Waters, S.A., Riddiough, G.E., Perini, M.V., Wilson, L.O.W., Baruteau, J., Diecke, S., Gonzalez-Aseguinolaza, G., Santilli, G., Thrasher, A.J., Alexander, I.E. and Lisowski, L.
Human Gene Therapy 34 (7-8): 273-288. April 2023

Generation of an induced pluripotent stem cell line from a Huntington's disease patient with a long HTT-PolyQ sequence.
Miller, D.C., Lisowski, P., Genehr, C., Wanker, E.E., Priller, J., Prigione, A. and Diecke, S.
Stem Cell Research 68 : 103056. April 2023

Generation of two mother-child pairs of iPSCs from maternally inherited Leigh syndrome patients with m.8993 T > G and m.9176 T > G MT-ATP6 mutations.
Henke, M.T., Zink, A., Diecke, S., Prigione, A. and Schuelke, M.
Stem Cell Research 67 : 103030. March 2023

2022

Robust induction of primordial germ cells of white rhinoceros on the brink of extinction.
Hayashi, M., Zywitza, V., Naitou, Y., Hamazaki, N., Goeritz, F., Hermes, R., Holtze, S., Lazzari, G., Galli, C., Stejskal, J., Diecke, S., Hildebrandt, T.B. and Hayashi, K.
Science Advances 8 (49): eabp9683. 9 December 2022

Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage.
Ercu, M., Mücke, M.B., Pallien, T., Markó, L., Sholokh, A., Schächterle, C., Aydin, A., Kidd, A., Walter, S., Esmati, Y., McMurray, B.J., Lato, D.F., Sunaga-Franze, D.Y., Dierks, P.H., Flores, B.I.M., Walker-Gray, R., Gong, M., Merticariu, C., Zühlke, K., Russwurm, M., Liu, T., Batolomaeus, T.U.P., Pautz, S., Schelenz, S., Taube, M., Napieczynska, H., Heuser, A., Eichhorst, J., Lehmann, M., Miller, D.C., Diecke, S., Qadri, F., Popova, E., Langanki, R., Movsesian, M.A., Herberg, F.W., Forslund, S.K., Müller, D.N., Borodina, T., Maass, P.G., Bähring, S., Hübner, N., Bader, M. and Klussmann, E.
Circulation 146 (23): 1758-1778. 6 December 2022

Generation of induced pluripotent stem cells from three individuals with Huntington's disease.
Miller, D.C., Lisowski, P., Lickfett, S., Mlody, B., Bünning, M., Genehr, C., Ulrich, C., Wanker, E.E., Diecke, S., Priller, J. and Prigione, A.
Stem Cell Research 65 : 102976. December 2022

Induced pluripotent stem cells and cerebral organoids from the critically endangered Sumatran rhinoceros.
Zywitza, V., Frahm, S., Krüger, N., Weise, A., Göritz, F., Hermes, R., Holtze, S., Colleoni, S., Galli, C., Drukker, M., Hildebrandt, T.B. and Diecke, S.
iScience 25 (11): 105414. 18 November 2022

The centrosomal protein 83 (CEP83) regulates human pluripotent stem cell differentiation towards the kidney lineage.
Mansour, F., Hinze, C., Telugu, N.S., Kresoja, J., Shaheed, I.B., Mosimann, C., Diecke, S. and Schmidt-Ott, K.M.
eLife 11 : e80165. 12 October 2022

Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy.
Perea-Gil, I., Seeger, T., Bruyneel, A.A.N., Termglinchan, V., Monte, E., Lim, E.W., Vadgama, N., Furihata, T., Gavidia, A.A., Arthur Ataam, J., Bharucha, N., Martinez-Amador, N., Ameen, M., Nair, P., Serrano, R., Kaur, B., Feyen, D.A.M., Diecke, S., Snyder, M.P., Metallo, C.M., Mercola, M. and Karakikes, I.
European Heart Journal 43 (36): 3477-3489. 21 September 2022

High-content analysis of neuronal morphology in human iPSC-derived neurons.
Lickfett, S., Menacho, C., Zink, A., Telugu, N.S., Beller, M., Diecke, S., Cambridge, S. and Prigione, A.
STAR Protocols 3 (3): 101567. 16 September 2022

Fluorescence spectroscopy of low-level endogenous β-adrenergic receptor expression at the plasma membrane of differentiating human iPSC-derived cardiomyocytes.
Gmach, P., Bathe-Peters, M., Telugu, N., Miller, D.C. and Annibale, P.
International Journal of Molecular Sciences 23 (18): 10405. 8 September 2022

Glutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine.
Schwab, K., Chasapopoulou, Z., Frahm, S., Magbagbeolu, M., Cranston, A., Harrington, C.R., Wischik, C.M., Theuring, F. and Riedel, G.
Cellular Signalling 97 : 110386. September 2022

A preclinical study on brugada syndrome with a CACNB2 variant using human cardiomyocytes from induced pluripotent stem cells.
Zhong, R., Schimanski, T., Zhang, F., Lan, H., Hohn, A., Xu, Q., Huang, M., Liao, Z., Qiao, L., Yang, Z., Li, Y., Zhao, Z., Li, X., Rose, L., Albers, S., Maywald, L., Müller, J., Dinkel, H., Saguner, A., Janssen, J.W.G., Telugu, N.S., Xi, Y., Lang, S., Kleinsorge, M., Duru, F., Zhou, X., Diecke, S., Cyganek, L., Akin, I. and El-Battrawy, I.
International Journal of Molecular Sciences 23 (15): 8313. 1 August 2022

Effects of separated pair housing of female C57BL/6JRj mice on well-being.
Hohlbaum, K., Merle, R., Frahm, S., Rex, A., Palme, R., Thöne-Reineke, C. and Ullmann, K.
Scientific Reports 12 (1): 8819. 25 May 2022

Generation of hiPSC-derived skeletal muscle cells: exploiting the potential of skeletal muscle-derived hiPSCs.
Metzler, E., Escobar, H., Sunaga-Franze, D.Y., Sauer, S., Diecke, S. and Spuler, S.
Biomedicines 10 (5): 1204. 23 May 2022

Generation of four iPSC lines from four patients with Leigh syndrome carrying homoplasmic mutations m.8993T > G or m.8993T > C in the mitochondrial gene MT-ATP6.
Lorenz, C., Zink, A., Henke, M.T., Staege, S., Mlody, B., Bünning, M., Wanker, E., Diecke, S., Schuelke, M. and Prigione, A.
Stem Cell Research 61 : 102742. May 2022

Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction.
Zywitza, V., Rusha, E., Shaposhnikov, D., Ruiz-Orera, J., Telugu, N., Rishko, V., Hayashi, M., Michel, G., Wittler, L., Stejskal, J., Holtze, S., Göritz, F., Hermes, R., Wang, J., Izsvák, Z., Colleoni, S., Lazzari, G., Galli, C., Hildebrandt, T.B., Hayashi, K., Diecke, S. and Drukker, M.
Scientific Reports 12 (1): 3100. 8 March 2022

One gene - two proteins: the C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria.
Fasciani, I., Petragnano, F., Wang, Z., Edwards, R., Telugu, N., Pietrantoni, I., Zauber, H., Rossi, M., Zabel, U., Grieben, M., Terzenidou, M.E., Di Gregorio, J., Pellegrini, C., Santini, S., Taddei, A.R., Poehl, B., Aringhieri, S., Aloisi, G., Marampon, F., Roman, A., Diecke, S., Flati, V., Giorgi, F., Amicarelli, F., Tobin, A.B., Scarselli, M., Tokatlidis, K., Lohse, M.J., Maggio, R. and Annibale, P.
bioRxiv : 2021.04.13.438299. 26 February 2022

Disruptors of AKAP-dependent protein-protein interactions.
Walker-Gray, R., Pallien, T., Miller, D.C., Oder, A., Neuenschwander, M., von Kries, J.P., Diecke, S. and Klussmann, E.
Methods in Molecular Biology 2483 : 117-139. 2022

2021

Deciphering the pathogenic role of a variant with uncertain significance for short QT and Brugada syndromes using gene-edited human-induced pluripotent stem cell-derived cardiomyocytes and preclinical drug screening.
El-Battrawy, I., Lan, H., Cyganek, L., Maywald, L., Zhong, R., Zhang, F., Xu, Q., Lee, J., Duperrex, E., Hierlemann, A., Saguner, A.M., Duru, F., Kovacs, B., Huang, M., Liao, Z., Albers, S., Müller, J., Dinkel, H., Rose, L., Hohn, A., Yang, Z., Qiao, L., Li, Y., Lang, S., Kleinsorge, M., Mügge, A., Aweimer, A., Fan, X., Diecke, S., Akin, I., Li, G. and Zhou, X.
Clinical and Translational Medicine 11 (12): e646. 26 December 2021

The ART of bringing extinction to a freeze - history and future of species conservation, exemplified by rhinos.
Hildebrandt, T.B., Hermes, R., Goeritz, F., Appeltant, R., Colleoni, S., de Mori, B., Diecke, S., Drukker, M., Galli, C., Hayashi, K., Lazzari, G., Loi, P., Payne, J., Renfree, M., Seet, S., Stejskal, J., Swegen, A., Williams, S.A., Zainuddin, Z.Z. and Holtze, S.
Theriogenology 169 : 76-88. 15 July 2021

Generation of 20 human induced pluripotent stem cell lines from patients with focal segmental glomerulosclerosis (FSGS).
Cernoch, J., Fisch, T., Fischer, I., Fischer, K., Iwanska, A., Krüger, N., Küchler, J., Schaar, C., Schommer, S., Telugu, N., Miller, D., Fernández Vallone, V., Kurtz, A., Reinke, P., Diecke, S. and Stachelscheid, H.
Stem Cell Research 54 : 102406. July 2021

Conservation research in times of COVID-19 - the rescue of the northern white rhino.
Hildebrandt, T.B., Holtze, S., Biasetti, P., Colleoni, S., de Mori, B., Diecke, S., Göritz, F., Hayashi, K., Hayashi, M., Hermes, R., Kariuki, L., Lazzari, G., Mijele, D., Mutisya, S., Ndeereh, D., Ngulu, S., Seet, S., Zwilling, J., Zywitza, V., Stejskal, J. and Galli, C.
Journal of Applied Animal Ethics Research 3 (1): 16-37. May 2021

Cores laboratories: organization for stem cell technology advancement.
Dahéron, L., Diecke, S., Healy, L. and D'Souza, S.
Stem Cell Research 53 : 102266. May 2021

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Inak, G., Rybak-Wolf, A., Lisowski, P., Pentimalli, T.M., Jüttner, R., Glažar, P., Uppal, K., Bottani, E., Brunetti, D., Secker, C., Zink, A., Meierhofer, D., Henke, M.T., Dey, M., Ciptasari, U., Mlody, B., Hahn, T., Berruezo-Llacuna, M., Karaiskos, N., Di Virgilio, M., Mayr, J.A., Wortmann, S.B., Priller, J., Gotthardt, M., Jones, D.P., Mayatepek, E., Stenzel, W., Diecke, S., Kühn, R., Wanker, E.E., Rajewsky, N., Schuelke, M. and Prigione, A.
Nature Communications 12 (1): 1929. 26 March 2021

Artificially produced gametes in mice, humans and other species.
Hayashi, K., Galli, C., Diecke, S. and Hildebrandt, T.B.
Reproduction Fertility and Development 33 (2): 91-101. 8 January 2021

2020

Methods for automated single cell isolation and sub-cloning of human pluripotent stem cells.
Vallone, V.F., Telugu, N.S., Fischer, I., Miller, D., Schommer, S., Diecke, S. and Stachelscheid, H.
Current Protocols in Stem Cell Biology 55 (1): e123. December 2020

Simple workflow and comparison of media for hPSC-cardiomyocyte cryopreservation and recovery.
Miller, D.C., Genehr, C., Telugu, N.S., Kurths, S. and Diecke, S.
Current Protocols in Stem Cell Biology 55 (1): e125. December 2020

Assessment of ethanol-induced toxicity on iPSC-derived human dopaminergic neurons using a novel high-throughput mitochondrial neuronal health (MNH) assay.
Zink, A., Conrad, J., Telugu, N.S., Diecke, S., Heinz, A., Wanker, E., Priller, J. and Prigione, A.
Frontiers in Cell and Developmental Biology 8 : 590540. 5 November 2020

Generation of three age and gender matched pairs of human induced pluripotent stem cells derived from myoblasts (MDCi011-A, MDCi012-A, MDCi013-A) and from peripheral blood mononuclear cells (MDCi011-B, MDCi012-B, MDCi013-B) from the same donor.
Metzler, E., Telugu, N., Diecke, S., Spuler, S. and Escobar, H.
Stem Cell Research 48 : 101987. October 2020

Generation of two human induced Pluripotent Stem Cell lines derived from myoblasts (MDCi014-A) and from peripheral blood mononuclear cells (MDCi014-B) from the same donor.
Metzler, E., Telugu, N., Diecke, S., Spuler, S. and Escobar, H.
Stem Cell Research 48 : 101998. October 2020

Endogenous retrovirus-derived lncRNA BANCR promotes cardiomyocyte migration in humans and non-human primates.
Wilson, K.D., Ameen, M., Guo, H., Abilez, O.J., Tian, L., Mumbach, M.R., Diecke, S., Qin, X., Liu, Y., Yang, H., Ma, N., Gaddam, S., Cunningham, N.J., Gu, M., Neofytou, E., Prado, M., Hildebrandt, T.B., Karakikes, I., Chang, H.Y. and Wu, J.C.
Developmental Cell 54 (6): 694-709. 28 September 2020

Intronic CRISPR repair in a preclinical model of Noonan syndrome-associated cardiomyopathy.
Hanses, U., Kleinsorge, M., Roos, L., Yigit, G., Li, Y., Barbarics, B., El-Battrawy, I., Lan, H., Tiburcy, M., Hindmarsh, R., Lenz, C., Salinas, G., Diecke, S., Müller, C., Adham, I., Altmüller, J., Nürnberg, P., Paul, T., Zimmermann, W.H., Hasenfuss, G., Wollnik, B. and Cyganek, L.
Circulation 142 (11): 1059-1076. 15 September 2020

Induced pluripotent stem cell-based disease modeling identifies ligand-induced decay of megalin as a cause of Donnai-Barrow syndrome.
Flemming, J., Marczenke, M., Rudolph, I.M., Nielsen, R., Storm, T., Ilsoe Christensen, E., Diecke, S., Emma, F. and Willnow, T.E.
Kidney International 98 (1): 159-167. July 2020

2019

Studying Brugada syndrome with an SCN1B variants in human-induced pluripotent stem cell-derived cardiomyocytes.
El-Battrawy, I., Müller, J., Zhao, Z., Cyganek, L., Zhong, R., Zhang, F., Kleinsorge, M., Lan, H., Li, X., Xu, Q., Huang, M., Liao, Z., Moscu-Gregor, A., Albers, S., Dinkel, H., Lang, S., Diecke, S., Zimmermann, W.H., Utikal, J., Wieland, T., Borggrefe, M., Zhou, X. and Akin, I.
Frontiers in Cell and Developmental Biology 7 : 261. 1 November 2019

A cellular model of Brugada syndrome with SCN10A variants using human-induced pluripotent stem cell-derived cardiomyocytes.
El-Battrawy, I., Albers, S., Cyganek, L., Zhao, Z., Lan, H., Li, X., Xu, Q., Kleinsorge, M., Huang, M., Liao, Z., Zhong, R., Rudic, B., Müller, J., Dinkel, H., Lang, S., Diecke, S., Zimmermann, W.H., Utikal, J., Wieland, T., Borggrefe, M., Zhou, X. and Akin, I.
Europace 21 (9): 1410-1421. September 2019

Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy.
Lee, J., Termglinchan, V., Diecke, S., Itzhaki, I., Lam, C.K., Garg, P., Lau, E., Greenhaw, M., Seeger, T., Wu, H., Zhang, J.Z, Chen, X., Gil, I.P., Ameen, M., Sallam, K., Rhee, J.W., Churko, J.M., Chaudhary, R., Chour, T., Wang, P.J., Snyder, M.P., Chang, H.Y., Karakikes, I. and Wu, J.C.
Nature 572 (7769): 335-340. 15 August 2019

The translational landscape of the human heart.
van Heesch, S., Witte, F., Schneider-Lunitz, V., Schulz, J.F., Adami, E., Faber, A., Kirchner, M., Maatz, H., Blachut, S., Sandmann, C.L., Kanda, M., Worth, C.L., Schafer, S., Calviello, L., Merriott, R., Patone, G., Hummel, O., Wyler, E., Obermayer, B., Mücke, M., Lindberg, E.L., Trnka, F., Memczak, S., Schilling, M., Felkin, L.E., Barton, P.J.R., Quaife, N.M., Vanezis, K., Diecke, S., Mukai, M., Mah, N., Oh, S.J., Kurtz, A., Schramm, C., Schwinge, D., Sebode, M., Harakalova, M., Asselbergs, F.W., Vink, A., de Weger, R.A., Viswanathan, S., Widjaja, A.A., Gärtner-Rommel, A., Milting, H., Dos Remedios, C., Knosalla, C., Mertins, P., Landthaler, M., Vingron, M., Linke, W.A., Seidman, J.G., Seidman, C.E., Rajewsky, N., Ohler, U., Cook, S.A. and Hubner, N.
Cell 178 (1): 242-260. 27 June 2019

Novel calcineurin A (PPP3CA) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression.
Rydzanicz, M., Wachowska, M., Cook, E.C., Lisowski, P., Kuźniewska, B., Szymańska, K., Diecke, S., Prigione, A., Szczałuba, K., Szybińska, A., Koppolu, A., Murcia Pienkowski, V., Kosińska, J., Wiweger, M., Kostrzewa, G., Brzozowska, M., Domańska-Pakieła, D., Jurkiewicz, E., Stawiński, P., Gromadka, A., Zielenkiewicz, P., Demkow, U., Dziembowska, M., Kuźnicki, J., Creamer, T.P. and Płoski, R.
European Journal of Human Genetics 27 (1): 61-69. January 2019

2018

Electroconductive biohybrid hydrogel for enhanced maturation and beating properties of engineered cardiac tissues.
Roshanbinfar, K., Vogt, L., Greber, B., Diecke, S., Boccaccini, A.R., Scheibel, T. and Engel, F.B.
Advanced Functional Materials 28 (42): 1803951. October 2018

Mutations in disordered regions can cause disease by creating dileucine motifs.
Meyer, K., Kirchner, M., Uyar, B., Cheng, J.Y., Russo, G., Hernandez-Miranda, L.R., Szymborska, A., Zauber, H., Rudolph, I.M., Willnow, T.E., Akalin, A., Haucke, V., Gerhardt, H., Birchmeier, C., Kühn, R., Krauss, M., Diecke, S., Pascual, J.M. and Selbach, M.
Cell 175 (1): 239-253. 20 September 2018

FACT sets a barrier for cell fate reprogramming in Caenorhabditis elegans and human cells.
Kolundzic, E., Ofenbauer, A., Bulut, S.I., Uyar, B., Baytek, G., Sommermeier, A., Seelk, S., He, M., Hirsekorn, A., Vucicevic, D., Akalin, A., Diecke, S., Lacadie, S.A. and Tursun, B.
Developmental Cell 46 (5): 611-626. 10 September 2018

Embryos and embryonic stem cells from the white rhinoceros.
Hildebrandt, T.B., Hermes, R., Colleoni, S., Diecke, S., Holtze, S., Renfree, M.B., Stejskal, J., Hayashi, K., Drukker, M., Loi, P., Göritz, F., Lazzari, G. and Galli, C.
Nature Communications 9 (1): 2589. 4 July 2018

Autologous iPSC-based vaccines elicit anti-tumor responses in vivo.
Kooreman, N.G., Kim, Y., de Almeida, P.E., Termglinchan, V., Diecke, S., Shao, N.Y., Wei, T.T., Yi, H., Dey, De., Nelakanti, R., Brouwer, T.P., Paik, D.T., Sagiv-Barfi, I., Han, A., Quax, P.H.A., Hamming, J.F., Levy, R., Davis, M.M. and Wu, J.C.
Cell Stem Cell 22 (4): 501-513. 5 April 2018

Human and equine endothelial cells in a live cell imaging scratch assay in vitro.
Rieger, J., Hopperdietzel, C., Kaessmeyer, S., Slosarek, I., Diecke, S., Richardson, K. and Plendl, J.
Clinical Hemorheology and Microcirculation 70 (4): 495-509. 2018

2017

Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods.
Churko, J.M., Lee, J., Ameen, M., Gu, M., Venkatasubramanian, M., Diecke, S., Sallam, K., Im, H., Wang, G., Gold, J.D., Salomonis, N., Snyder, M.P. and Wu, J.C.
Nature Biomedical Engineering 1 (10): 826-837. October 2017

Alloimmune responses of humanized mice to human pluripotent stem cell therapeutics.
Kooreman, N.G., de Almeida, P.E., Stack, J.P., Nelakanti, R.V., Diecke, S., Shao, N.Y., Swijnenburg, R.J., Sanchez-Freire, V., Matsa, E., Liu, C., Connolly, A.J., Hamming, J.F., Quax, P.H.A., Brehm, M.A., Greiner, D.L., Shultz, L.D. and Wu, J.C.
Cell Reports 20 (8): 1978-1990. 22 August 2017

A comprehensive TALEN-based knockout library for generating human induced pluripotent stem cell-based models for cardiovascular diseases.
Karakikes, I., Termglinchan, V., Cepeda, D.A., Lee, J., Diecke, S., Hendel, A., Itzhaki, I., Ameen, M., Shrestha, R., Wu, H., Ma, N., Shao, N.Y., Seeger, T., Woo, N.A., Wilson, K.D., Matsa, E., Porteus, M.H., Sebastiano, V. and Wu, J.C.
Circulation Research 120 (10): 1561-1571. 12 May 2017

2016

Generation of functional cardiomyocytes from the synoviocytes of patients with rheumatoid arthritis via induced pluripotent stem cells.
Lee, J., Jung, S.M., Ebert, A.D., Wu, H., Diecke, S., Kim, Y., Yi, H., Park, S.H. and Ju, J.H.
Scientific Reports 6 : 32669. 9 September 2016

Rewinding the process of mammalian extinction.
Saragusty, J., Diecke, S., Drukker, M., Durrant, B., Friedrich Ben-Nun, I., Galli, C., Goeritz, F., Hayashi, K., Hermes, R., Holtze, S., Johnson, S., Lazzari, G., Loi, P., Loring, J.F., Okita, K., Renfree, M.B., Seet, S., Voracek, T., Stejskal, J., Ryder, O.A. and Hildebrandt, T.B.
Zoo Biology 35 (4): 280-292. July 2016

Modeling cardiovascular diseases with patient-specific human pluripotent stem cell-derived cardiomyocytes.
Burridge, P.W., Diecke, S., Matsa, E., Sharma, A., Wu, H. and Wu, J.C.
Methods in Molecular Biology 1353 : 119-130. 2016

2015

Microfluidic single-cell analysis of transplanted human induced pluripotent stem cell-derived cardiomyocytes after acute myocardial infarction.
Ong, S.G., Huber, B.C., Lee, W.H., Kodo, K., Ebert, A.D., Ma, Y., Nguyen, P.K., Diecke, S., Chen, W.Y. and Wu, J.C.
Circulation 132 (8): 762-771. 25 August 2015

Reprogramming and transdifferentiation for cardiovascular development and regenerative medicine: where do we stand?
Ebert, A.D., Diecke, S., Chen, I.Y. and Wu, J.C.
EMBO Molecular Medicine 7 (9): 1090-1103. 16 July 2015

Pravastatin reverses obesity-induced dysfunction of induced pluripotent stem cell-derived endothelial cells via a nitric oxide-dependent mechanism.
Gu, M., Mordwinkin, N.M., Kooreman, N.G., Lee, J., Wu, H., Hu, S., Churko, J.M., Diecke, S., Burridge, P.W., He, C., Barron, F.E., Ong, S.G., Gold, J.D. and Wu, J.C
European Heart Journal 36 (13): 806-16. 1 April 2015

Improved approach for chondrogenic differentiation of human induced pluripotent stem cells.
Nejadnik, H., Diecke, S., Lenkov, O.D., Chapelin, F., Donig, J., Tong, X., Derugin, N., Chan, R.C.F., Gaur, A., Yang, F., Wu, J.C. and Daldrup-Link, H.E.
Stem Cell Reviews and Reports 11 (2): 242-253. April 2015

2014

Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system.
Ebert, A.D., Kodo, K., Liang, P., Wu, H., Huber, B.C., Riegler, J., Churko, J., Lee, J., de Almeida, P., Lan, F., Diecke, S., Burridge, P.W., Gold, J.D., Mochly-Rosen, D. and Wu, J.C.
Science Translational Medicine 6 (255): 255ra130. 24 September 2014

Recent technological updates and clinical applications of induced pluripotent stem cells.
Diecke, S., Jung, S.M., Lee, J. and Ju, J.H.
Korean Journal of Internal Medicine 29 (5): 547-57. September 2014

Human induced pluripotent stem cell-derived cardiomyocytes as an in vitro model for coxsackievirus B3-induced myocarditis and antiviral drug screening platform.
Sharma, A., Marceau, C., Hamaguchi, R., Burridge, P.W., Rajarajan, K., Churko, J.M., Wu, H., Sallam, K.I., Matsa, E., Sturzu, A.C., Che, Y., Ebert, A., Diecke, S., Liang, P., Red-Horse, K., Carette, J.E., Wu, S.M. and Wu, J.C.
Circulation Research 115 (6): 556-66. 29 August 2014

Chemically defined generation of human cardiomyocytes.
Burridge, P.W., Matsa, E., Shukla, P., Lin, Z.C., Churko, J.M., Ebert, A.D., Lan, F., Diecke, S., Huber, B., Mordwinkin, N.M., Plews, J.R., Abilez, O.J., Cui, B., Gold, J.D. and Wu, J.C.
Nature Methods 11 (8): 855-60. August 2014

Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance.
de Almeida, P.E., Meyer, E.H., Kooreman, N.G., Diecke, S., Dey, D., Sanchez-Freire, V., Hu, S., Ebert, A., Odegaard, J., Mordwinkin, N.M., Brouwer, T.P., Lo, D., Montoro, D.T., Longaker, M.T., Negrin, R.S. and Wu, J.C.
Nature Communications 5 : 3903. 30 May 2014

Generation of disease-specific induced pluripotent stem cells from patients with rheumatoid arthritis and osteoarthritis.
Lee, J., Kim, Y., Yi, H., Diecke, S., Kim, J., Jung, H., Rim, Y.A., Jung, S.M., Kim, M., Kim, Y.G., Park, S.H., Kim, H.Y. and Ju, J.H.
Arthritis Research & Therapy 16 (1): R41. 4 February 2014

Second generation codon optimized minicircle (CoMiC) for nonviral reprogramming of human adult fibroblasts.
Diecke, S., Lisowski, L., Kooreman, N.G. and Wu, J.C.
Methods in Molecular Biology 1181 : 1-13. 1 January 2014

2013

Costimulation-adhesion blockade is superior to cyclosporine A and prednisone immunosuppressive therapy for preventing rejection of differentiated human embryonic stem cells following transplantation.
Huber, B.C., Ransohoff, J.D., Ransohoff, K.J., Riegler, J., Ebert, A., Kodo, K., Gong, Y., Sanchez-Freire, V., Dey, D., Kooreman, N.G., Diecke, S., Zhang, W.Y., Odegaard, J., Hu, S., Gold, J.D., Robbins, R.C. and Wu, J.C.
Stem Cells 31 (11): 2354-63. November 2013

The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells.
Sharma, A., Diecke, S., Zhang, W.Y., Lan, F., He, C., Mordwinkin, N.M., Chua, K.F. and Wu, J.C.
Journal of Biological Chemistry 288 (25): 18439-47. 21 June 2013

Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity.
Liang, P., Lan, F., Lee, A.S., Gong, T., Sanchez-Freire, V., Wang, Y., Diecke, S., Sallam, K., Knowles, J.W., Wang, P.J., Nguyen, P.K., Bers, D.M., Robbins, R.C. and Wu, J.C.
Circulation 127 (16): 1677-91. 23 April 2013