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Characterization of two iPSC lines from patients with maternally inherited leigh (MILS) and neuropathy, ataxia, and retinitis pigmentosa (NARP) syndrome carrying the MT-ATP6 m.8993 T>G mutation at different degrees of heteroplasmy.
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December 2023
Neurofibromin 1 mutations impair the function of human induced pluripotent stem cell-derived microglia.
Kuhrt, L.D. ORCID: https://orcid.org/0000-0001-7157-6988, Motta, E. ORCID: https://orcid.org/0000-0003-2526-7994, Elmadany, N. ORCID: https://orcid.org/0000-0001-9038-8368, Weidling, H., Fritsche-Guenther, R. ORCID: https://orcid.org/0000-0002-6965-0226, Efe, I.E. ORCID: https://orcid.org/0000-0002-4232-3305, Cobb, O., Chatterjee, J., Boggs, L.G., Schnauß, M., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Semtner, M. ORCID: https://orcid.org/0000-0001-9379-9023, Anastasaki, C. ORCID: https://orcid.org/0000-0002-9928-6488, Gutmann, D.H. ORCID: https://orcid.org/0000-0002-3127-5045 and Kettenmann, H. ORCID: https://orcid.org/0000-0001-8208-0291
Disease Models & Mechanisms 16
(12): dmm049861.
December 2023
In vitro fertilization program in white rhinoceros.
Hildebrandt, T.B., Holtze, S. ORCID: https://orcid.org/0000-0002-4654-1916, Colleoni, S., Hermes, R., Stejskal, J., Lekolool, I., Ndereeh, D., Omondi, P., Kariuki, L., Mijele, D., Mutisya, S., Ngulu, S., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Hayashi, K., Lazzari, G., de Mori, B., Biasetti, P., Quaggio, A., Galli, C. ORCID: https://orcid.org/0000-0002-9529-6136 and Goeritz, F.
Reproduction 166
(6): 383-399.
25 October 2023
Phosphatidylinositol 3,5-bisphosphate facilitates axonal vesicle transport and presynapse assembly.
Rizalar, F.S. ORCID: https://orcid.org/0000-0002-9103-4681, Lucht, M.T. ORCID: https://orcid.org/0000-0001-5785-3889, Petzoldt, A. ORCID: https://orcid.org/0000-0002-4059-7142, Kong, S., Sun, J. ORCID: https://orcid.org/0000-0002-0278-6831, Vines, J.H., Telugu, N.S. ORCID: https://orcid.org/0000-0003-4509-7056, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Kaas, T. ORCID: https://orcid.org/0000-0001-5281-9032, Bullmann, T. ORCID: https://orcid.org/0000-0001-6637-0221, Schmied, C. ORCID: https://orcid.org/0000-0003-2058-1124, Löwe, D., King, J.S. ORCID: https://orcid.org/0000-0003-0596-4506, Cho, W., Hallermann, S. ORCID: https://orcid.org/0000-0001-9376-7048, Puchkov, D. ORCID: https://orcid.org/0000-0001-8341-4847, Sigrist, S.J. ORCID: https://orcid.org/0000-0002-1698-5815 and Haucke, V. ORCID: https://orcid.org/0000-0003-3119-6993
Science 382
(6667): 223-230.
12 October 2023
ASSURED-optimized CRISPR protocol for knockout/SNP knockin in hiPSCs.
Ludwik, K.A. ORCID: https://orcid.org/0000-0002-9436-7270, Telugu, N. ORCID: https://orcid.org/0000-0003-4509-7056, Schommer, S., Stachelscheid, H. and Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992
STAR Protocols 4
(3): 102406.
15 September 2023
A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals.
Lázaro, J., Costanzo, M., Sanaki-Matsumiya, M., Girardot, C., Hayashi, M. ORCID: https://orcid.org/0000-0003-3286-9029, Hayashi, K. ORCID: https://orcid.org/0000-0002-2479-2941, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Hildebrandt, T.B., Lazzari, G., Wu, J., Petkov, S., Behr, R., Trivedi, V., Matsuda, M. and Ebisuya, M. ORCID: https://orcid.org/0000-0003-1854-7496
Cell Stem Cell 30
(7): 938-949.e7.
6 July 2023
iPSC-derived reactive astrocytes from patients with multiple-sclerosis protect cocultured neurons in inflammatory conditions.
Kerkering, J. ORCID: https://orcid.org/0000-0002-6432-7104, Muinjonov, B., Rosiewicz, K.S. ORCID: https://orcid.org/0000-0002-6926-7227, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Biese, C., Schiweck, J., Chien, C. ORCID: https://orcid.org/0000-0001-8280-9513, Zocholl, D., Conrad, T. ORCID: https://orcid.org/0000-0001-5618-6295, Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070, Alisch, M. ORCID: https://orcid.org/0009-0000-8316-6193 and Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868
Journal of Clinical Investigation 133
(13): e164637.
3 July 2023
Assessment of pre-clinical liver models based on their ability to predict the liver-tropism of adeno-associated virus vectors.
Westhaus, A., Cabanes Creus, M., Dilworth, K.L., Zhu, E., Salas, D., Navarro, R.G., Amaya, A.K., Scott, A., Kwiatek, M., McCorkindale, A.L., Hayman, T.E., Frahm, S. ORCID: https://orcid.org/0000-0001-5645-2557, Perocheau, D., Tran, B.M., Vincan, E., Wong, S.L., Waters, S.A., Riddiough, G.E., Perini, M.V., Wilson, L.O.W., Baruteau, J., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Gonzalez-Aseguinolaza, G., Santilli, G., Thrasher, A.J., Alexander, I.E. and Lisowski, L.
Human Gene Therapy 34
(7-8): 273-288.
April 2023
Generation of an induced pluripotent stem cell line from a Huntington's disease patient with a long HTT-PolyQ sequence.
Miller, D.C. ORCID: https://orcid.org/0000-0001-9852-677X, Lisowski, P. ORCID: https://orcid.org/0000-0002-3634-1072, Genehr, C., Wanker, E.E. ORCID: https://orcid.org/0000-0001-8072-1630, Priller, J. ORCID: https://orcid.org/0000-0001-7596-0979, Prigione, A. ORCID: https://orcid.org/0000-0001-9457-1952 and Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992
Stem Cell Research 68
: 103056.
April 2023
Generation of two mother-child pairs of iPSCs from maternally inherited Leigh syndrome patients with m.8993 T > G and m.9176 T > G MT-ATP6 mutations.
Henke, M.T. ORCID: https://orcid.org/0000-0001-6572-1667, Zink, A. ORCID: https://orcid.org/0000-0002-8489-6339, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Prigione, A. ORCID: https://orcid.org/0000-0001-9457-1952 and Schuelke, M. ORCID: https://orcid.org/0000-0003-2824-3891
Stem Cell Research 67
: 103030.
March 2023
2022
Robust induction of primordial germ cells of white rhinoceros on the brink of extinction.
Hayashi, M. ORCID: https://orcid.org/0000-0003-3286-9029, Zywitza, V. ORCID: https://orcid.org/0000-0003-3055-8569, Naitou, Y. ORCID: https://orcid.org/0000-0002-8470-5539, Hamazaki, N. ORCID: https://orcid.org/0000-0001-9228-233X, Goeritz, F. ORCID: https://orcid.org/0000-0002-5353-7499, Hermes, R. ORCID: https://orcid.org/0000-0003-2487-9171, Holtze, S. ORCID: https://orcid.org/0000-0002-4654-1916, Lazzari, G., Galli, C. ORCID: https://orcid.org/0000-0002-9529-6136, Stejskal, J. ORCID: https://orcid.org/0000-0001-8179-2852, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Hildebrandt, T.B. ORCID: https://orcid.org/0000-0001-8685-4733 and Hayashi, K. ORCID: https://orcid.org/0000-0002-2479-2941
Science Advances 8
(49): eabp9683.
9 December 2022
Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage.
Ercu, M., Mücke, M.B. ORCID: https://orcid.org/0000-0002-4957-3307, Pallien, T., Markó, L. ORCID: https://orcid.org/0000-0003-1888-5575, Sholokh, A. ORCID: https://orcid.org/0000-0002-1263-2078, Schächterle, C., Aydin, A. ORCID: https://orcid.org/0000-0002-2890-0225, Kidd, A., Walter, S. ORCID: https://orcid.org/0000-0002-2041-2921, Esmati, Y. ORCID: https://orcid.org/0000-0001-9010-8119, McMurray, B.J. ORCID: https://orcid.org/0000-0003-3394-0667, Lato, D.F. ORCID: https://orcid.org/0000-0002-9263-8532, Sunaga-Franze, D.Y. ORCID: https://orcid.org/0000-0002-6851-9162, Dierks, P.H. ORCID: https://orcid.org/0000-0001-5903-8343, Flores, B.I.M., Walker-Gray, R., Gong, M. ORCID: https://orcid.org/0000-0001-7384-3429, Merticariu, C., Zühlke, K., Russwurm, M., Liu, T., Batolomaeus, T.U.P. ORCID: https://orcid.org/0000-0002-5156-7184, Pautz, S., Schelenz, S., Taube, M., Napieczynska, H. ORCID: https://orcid.org/0000-0001-5091-1185, Heuser, A. ORCID: https://orcid.org/0000-0002-3334-960X, Eichhorst, J., Lehmann, M., Miller, D.C. ORCID: https://orcid.org/0000-0001-9852-677X, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Qadri, F. ORCID: https://orcid.org/0000-0002-8500-489X, Popova, E. ORCID: https://orcid.org/0000-0002-3043-9650, Langanki, R., Movsesian, M.A., Herberg, F.W. ORCID: https://orcid.org/0000-0001-7117-7653, Forslund, S.K. ORCID: https://orcid.org/0000-0003-4285-6993, Müller, D.N. ORCID: https://orcid.org/0000-0003-3650-5644, Borodina, T. ORCID: https://orcid.org/0000-0002-6978-016X, Maass, P.G. ORCID: https://orcid.org/0000-0002-2742-8301, Bähring, S. ORCID: https://orcid.org/0000-0001-8734-9755, Hübner, N. ORCID: https://orcid.org/0000-0002-1218-6223, Bader, M. ORCID: https://orcid.org/0000-0003-4780-4164 and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Circulation 146
(23): 1758-1778.
6 December 2022
Generation of induced pluripotent stem cells from three individuals with Huntington's disease.
Miller, D.C. ORCID: https://orcid.org/0000-0001-9852-677X, Lisowski, P. ORCID: https://orcid.org/0000-0002-3634-1072, Lickfett, S., Mlody, B. ORCID: https://orcid.org/0000-0001-5184-1772, Bünning, M., Genehr, C., Ulrich, C., Wanker, E.E. ORCID: https://orcid.org/0000-0001-8072-1630, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Priller, J. ORCID: https://orcid.org/0000-0001-7596-0979 and Prigione, A. ORCID: https://orcid.org/0000-0001-9457-1952
Stem Cell Research 65
: 102976.
December 2022
Induced pluripotent stem cells and cerebral organoids from the critically endangered Sumatran rhinoceros.
Zywitza, V. ORCID: https://orcid.org/0000-0003-3055-8569, Frahm, S. ORCID: https://orcid.org/0000-0001-5645-2557, Krüger, N., Weise, A., Göritz, F., Hermes, R., Holtze, S., Colleoni, S., Galli, C., Drukker, M., Hildebrandt, T.B. and Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992
iScience 25
(11): 105414.
18 November 2022
The centrosomal protein 83 (CEP83) regulates human pluripotent stem cell differentiation towards the kidney lineage.
Mansour, F. ORCID: https://orcid.org/0000-0003-4808-3514, Hinze, C. ORCID: https://orcid.org/0000-0003-2526-1621, Telugu, N.S. ORCID: https://orcid.org/0000-0003-4509-7056, Kresoja, J., Shaheed, I.B., Mosimann, C. ORCID: https://orcid.org/0000-0002-0749-2576, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992 and Schmidt-Ott, K.M. ORCID: https://orcid.org/0000-0002-7700-7142
eLife 11
: e80165.
12 October 2022
Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy.
Perea-Gil, I. ORCID: https://orcid.org/0000-0002-9741-428X, Seeger, T., Bruyneel, A.A.N. ORCID: https://orcid.org/0000-0003-1076-4381, Termglinchan, V. ORCID: https://orcid.org/0000-0002-6559-0668, Monte, E. ORCID: https://orcid.org/0000-0003-2566-1967, Lim, E.W., Vadgama, N. ORCID: https://orcid.org/0000-0001-6226-3867, Furihata, T. ORCID: https://orcid.org/0000-0002-0473-5958, Gavidia, A.A. ORCID: https://orcid.org/0000-0002-9347-4664, Arthur Ataam, J., Bharucha, N., Martinez-Amador, N. ORCID: https://orcid.org/0000-0002-5787-7183, Ameen, M., Nair, P. ORCID: https://orcid.org/0000-0001-5942-966X, Serrano, R. ORCID: https://orcid.org/0000-0002-4206-3638, Kaur, B., Feyen, D.A.M., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Snyder, M.P. ORCID: https://orcid.org/0000-0003-0784-7987, Metallo, C.M., Mercola, M. ORCID: https://orcid.org/0000-0002-1430-2013 and Karakikes, I. ORCID: https://orcid.org/0000-0002-4348-600X
European Heart Journal 43
(36): 3477-3489.
21 September 2022
High-content analysis of neuronal morphology in human iPSC-derived neurons.
Lickfett, S., Menacho, C., Zink, A. ORCID: https://orcid.org/0000-0002-8489-6339, Telugu, N.S. ORCID: https://orcid.org/0000-0003-4509-7056, Beller, M., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Cambridge, S. and Prigione, A. ORCID: https://orcid.org/0000-0001-9457-1952
STAR Protocols 3
(3): 101567.
16 September 2022
Fluorescence spectroscopy of low-level endogenous β-adrenergic receptor expression at the plasma membrane of differentiating human iPSC-derived cardiomyocytes.
Gmach, P. ORCID: https://orcid.org/0000-0002-5258-0321, Bathe-Peters, M. ORCID: https://orcid.org/0000-0002-9618-0856, Telugu, N. ORCID: https://orcid.org/0000-0003-4509-7056, Miller, D.C. ORCID: https://orcid.org/0000-0001-9852-677X and Annibale, P. ORCID: https://orcid.org/0000-0003-3208-5347
International Journal of Molecular Sciences 23
(18): 10405.
8 September 2022
Glutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine.
Schwab, K., Chasapopoulou, Z. ORCID: https://orcid.org/0000-0002-6980-0757, Frahm, S. ORCID: https://orcid.org/0000-0001-5645-2557, Magbagbeolu, M., Cranston, A., Harrington, C.R., Wischik, C.M., Theuring, F. and Riedel, G.
Cellular Signalling 97
: 110386.
September 2022
A preclinical study on brugada syndrome with a CACNB2 variant using human cardiomyocytes from induced pluripotent stem cells.
Zhong, R., Schimanski, T., Zhang, F., Lan, H., Hohn, A. ORCID: https://orcid.org/0000-0001-9624-3098, Xu, Q., Huang, M., Liao, Z., Qiao, L., Yang, Z., Li, Y., Zhao, Z., Li, X., Rose, L. ORCID: https://orcid.org/0000-0002-8563-4357, Albers, S., Maywald, L. ORCID: https://orcid.org/0000-0001-5163-3383, Müller, J., Dinkel, H., Saguner, A., Janssen, J.W.G., Telugu, N.S. ORCID: https://orcid.org/0000-0003-4509-7056, Xi, Y., Lang, S., Kleinsorge, M., Duru, F., Zhou, X. ORCID: https://orcid.org/0000-0002-5895-0127, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Cyganek, L., Akin, I. and El-Battrawy, I.
International Journal of Molecular Sciences 23
(15): 8313.
1 August 2022
Effects of separated pair housing of female C57BL/6JRj mice on well-being.
Hohlbaum, K., Merle, R., Frahm, S. ORCID: https://orcid.org/0000-0001-5645-2557, Rex, A., Palme, R., Thöne-Reineke, C. and Ullmann, K.
Scientific Reports 12
(1): 8819.
25 May 2022
Generation of hiPSC-derived skeletal muscle cells: exploiting the potential of skeletal muscle-derived hiPSCs.
Metzler, E. ORCID: https://orcid.org/0000-0003-1735-6364, Escobar, H. ORCID: https://orcid.org/0000-0002-8128-7845, Sunaga-Franze, D.Y. ORCID: https://orcid.org/0000-0002-6851-9162, Sauer, S. ORCID: https://orcid.org/0000-0002-4794-3693, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992 and Spuler, S. ORCID: https://orcid.org/0000-0002-0155-1117
Biomedicines 10
(5): 1204.
23 May 2022
Generation of four iPSC lines from four patients with Leigh syndrome carrying homoplasmic mutations m.8993T > G or m.8993T > C in the mitochondrial gene MT-ATP6.
Lorenz, C. ORCID: https://orcid.org/0000-0002-7762-8133, Zink, A. ORCID: https://orcid.org/0000-0002-8489-6339, Henke, M.T. ORCID: https://orcid.org/0000-0001-6572-1667, Staege, S., Mlody, B. ORCID: https://orcid.org/0000-0001-5184-1772, Bünning, M., Wanker, E. ORCID: https://orcid.org/0000-0001-8072-1630, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Schuelke, M. ORCID: https://orcid.org/0000-0003-2824-3891 and Prigione, A. ORCID: https://orcid.org/0000-0001-9457-1952
Stem Cell Research 61
: 102742.
May 2022
Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction.
Zywitza, V. ORCID: https://orcid.org/0000-0003-3055-8569, Rusha, E., Shaposhnikov, D., Ruiz-Orera, J. ORCID: https://orcid.org/0000-0002-8317-0034, Telugu, N. ORCID: https://orcid.org/0000-0003-4509-7056, Rishko, V., Hayashi, M., Michel, G., Wittler, L., Stejskal, J., Holtze, S., Göritz, F., Hermes, R., Wang, J. ORCID: https://orcid.org/0000-0002-7027-0298, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Colleoni, S., Lazzari, G., Galli, C., Hildebrandt, T.B., Hayashi, K., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992 and Drukker, M.
Scientific Reports 12
(1): 3100.
8 March 2022
Disruptors of AKAP-dependent protein-protein interactions.
Walker-Gray, R., Pallien, T., Miller, D.C. ORCID: https://orcid.org/0000-0001-9852-677X, Oder, A., Neuenschwander, M. ORCID: https://orcid.org/0000-0002-3114-7975, von Kries, J.P. ORCID: https://orcid.org/0000-0003-4716-4988, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992 and Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003
Methods in Molecular Biology 2483
: 117-139.
2022
2021
Deciphering the pathogenic role of a variant with uncertain significance for short QT and Brugada syndromes using gene-edited human-induced pluripotent stem cell-derived cardiomyocytes and preclinical drug screening.
El-Battrawy, I. ORCID: https://orcid.org/0000-0002-0139-1045, Lan, H., Cyganek, L., Maywald, L., Zhong, R., Zhang, F., Xu, Q., Lee, J., Duperrex, E., Hierlemann, A., Saguner, A.M., Duru, F., Kovacs, B., Huang, M., Liao, Z., Albers, S., Müller, J., Dinkel, H., Rose, L., Hohn, A., Yang, Z., Qiao, L., Li, Y., Lang, S., Kleinsorge, M., Mügge, A., Aweimer, A., Fan, X., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Akin, I., Li, G. and Zhou, X.
Clinical and Translational Medicine 11
(12): e646.
26 December 2021
The ART of bringing extinction to a freeze - history and future of species conservation, exemplified by rhinos.
Hildebrandt, T.B., Hermes, R. ORCID: https://orcid.org/0000-0003-2487-9171, Goeritz, F., Appeltant, R., Colleoni, S., de Mori, B., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Drukker, M., Galli, C., Hayashi, K., Lazzari, G., Loi, P., Payne, J., Renfree, M., Seet, S., Stejskal, J., Swegen, A., Williams, S.A., Zainuddin, Z.Z. and Holtze, S. ORCID: https://orcid.org/0000-0002-4654-1916
Theriogenology 169
: 76-88.
15 July 2021
Generation of 20 human induced pluripotent stem cell lines from patients with focal segmental glomerulosclerosis (FSGS).
Cernoch, J., Fisch, T. ORCID: https://orcid.org/0000-0001-5017-4306, Fischer, I., Fischer, K., Iwanska, A., Krüger, N., Küchler, J., Schaar, C. ORCID: https://orcid.org/0000-0002-0310-9963, Schommer, S., Telugu, N. ORCID: https://orcid.org/0000-0003-4509-7056, Miller, D. ORCID: https://orcid.org/0000-0001-9852-677X, Fernández Vallone, V., Kurtz, A., Reinke, P., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992 and Stachelscheid, H. ORCID: https://orcid.org/0000-0002-9283-4605
Stem Cell Research 54
: 102406.
July 2021
Conservation research in times of COVID-19 - the rescue of the northern white rhino.
Hildebrandt, T.B., Holtze, S., Biasetti, P., Colleoni, S., de Mori, B., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Göritz, F., Hayashi, K., Hayashi, M., Hermes, R., Kariuki, L., Lazzari, G., Mijele, D., Mutisya, S., Ndeereh, D., Ngulu, S., Seet, S., Zwilling, J., Zywitza, V. ORCID: https://orcid.org/0000-0003-3055-8569, Stejskal, J. and Galli, C.
Journal of Applied Animal Ethics Research 3
(1): 16-37.
May 2021
Cores laboratories: organization for stem cell technology advancement.
Dahéron, L., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Healy, L. and D'Souza, S.
Stem Cell Research 53
: 102266.
May 2021
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
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Nature Communications 12
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26 March 2021
Artificially produced gametes in mice, humans and other species.
Hayashi, K. ORCID: https://orcid.org/0000-0002-2479-2941, Galli, C., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992 and Hildebrandt, T.B.
Reproduction Fertility and Development 33
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8 January 2021
2020
Methods for automated single cell isolation and sub-cloning of human pluripotent stem cells.
Vallone, V.F., Telugu, N.S. ORCID: https://orcid.org/0000-0003-4509-7056, Fischer, I., Miller, D. ORCID: https://orcid.org/0000-0001-9852-677X, Schommer, S., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992 and Stachelscheid, H.
Current Protocols in Stem Cell Biology 55
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December 2020
Simple workflow and comparison of media for hPSC-cardiomyocyte cryopreservation and recovery.
Miller, D.C. ORCID: https://orcid.org/0000-0001-9852-677X, Genehr, C., Telugu, N.S. ORCID: https://orcid.org/0000-0003-4509-7056, Kurths, S. and Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992
Current Protocols in Stem Cell Biology 55
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December 2020
Assessment of ethanol-induced toxicity on iPSC-derived human dopaminergic neurons using a novel high-throughput mitochondrial neuronal health (MNH) assay.
Zink, A. ORCID: https://orcid.org/0000-0002-8489-6339, Conrad, J., Telugu, N.S. ORCID: https://orcid.org/0000-0003-4509-7056, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Heinz, A., Wanker, E. ORCID: https://orcid.org/0000-0001-8072-1630, Priller, J. ORCID: https://orcid.org/0000-0001-7596-0979 and Prigione, A. ORCID: https://orcid.org/0000-0001-9457-1952
Frontiers in Cell and Developmental Biology 8
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5 November 2020
Generation of three age and gender matched pairs of human induced pluripotent stem cells derived from myoblasts (MDCi011-A, MDCi012-A, MDCi013-A) and from peripheral blood mononuclear cells (MDCi011-B, MDCi012-B, MDCi013-B) from the same donor.
Metzler, E. ORCID: https://orcid.org/0000-0003-1735-6364, Telugu, N. ORCID: https://orcid.org/0000-0003-4509-7056, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Spuler, S. ORCID: https://orcid.org/0000-0002-0155-1117 and Escobar, H. ORCID: https://orcid.org/0000-0002-8128-7845
Stem Cell Research 48
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October 2020
Generation of two human induced Pluripotent Stem Cell lines derived from myoblasts (MDCi014-A) and from peripheral blood mononuclear cells (MDCi014-B) from the same donor.
Metzler, E. ORCID: https://orcid.org/0000-0003-1735-6364, Telugu, N. ORCID: https://orcid.org/0000-0003-4509-7056, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Spuler, S. ORCID: https://orcid.org/0000-0002-0155-1117 and Escobar, H. ORCID: https://orcid.org/0000-0002-8128-7845
Stem Cell Research 48
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October 2020
Endogenous retrovirus-derived lncRNA BANCR promotes cardiomyocyte migration in humans and non-human primates.
Wilson, K.D., Ameen, M., Guo, H., Abilez, O.J., Tian, L., Mumbach, M.R., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Qin, X., Liu, Y., Yang, H., Ma, N., Gaddam, S., Cunningham, N.J., Gu, M., Neofytou, E., Prado, M., Hildebrandt, T.B., Karakikes, I., Chang, H.Y. and Wu, J.C.
Developmental Cell 54
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28 September 2020
Intronic CRISPR repair in a preclinical model of Noonan syndrome-associated cardiomyopathy.
Hanses, U., Kleinsorge, M., Roos, L., Yigit, G., Li, Y., Barbarics, B., El-Battrawy, I., Lan, H., Tiburcy, M., Hindmarsh, R., Lenz, C., Salinas, G., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Müller, C., Adham, I., Altmüller, J. ORCID: https://orcid.org/0000-0003-4372-1521, Nürnberg, P., Paul, T., Zimmermann, W.H., Hasenfuss, G., Wollnik, B. and Cyganek, L.
Circulation 142
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15 September 2020
Induced pluripotent stem cell-based disease modeling identifies ligand-induced decay of megalin as a cause of Donnai-Barrow syndrome.
Flemming, J., Marczenke, M., Rudolph, I.M. ORCID: https://orcid.org/0000-0002-3903-0755, Nielsen, R., Storm, T., Ilsoe Christensen, E., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Emma, F. and Willnow, T.E. ORCID: https://orcid.org/0000-0001-9515-7921
Kidney International 98
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July 2020
2019
Studying Brugada syndrome with an SCN1B variants in human-induced pluripotent stem cell-derived cardiomyocytes.
El-Battrawy, I., Müller, J., Zhao, Z., Cyganek, L., Zhong, R., Zhang, F., Kleinsorge, M., Lan, H., Li, X., Xu, Q., Huang, M., Liao, Z., Moscu-Gregor, A., Albers, S., Dinkel, H., Lang, S., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Zimmermann, W.H., Utikal, J., Wieland, T., Borggrefe, M., Zhou, X. and Akin, I.
Frontiers in Cell and Developmental Biology 7
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1 November 2019
A cellular model of Brugada syndrome with SCN10A variants using human-induced pluripotent stem cell-derived cardiomyocytes.
El-Battrawy, I. ORCID: https://orcid.org/0000-0002-0139-1045, Albers, S., Cyganek, L., Zhao, Z., Lan, H., Li, X., Xu, Q., Kleinsorge, M., Huang, M., Liao, Z., Zhong, R., Rudic, B., Müller, J., Dinkel, H., Lang, S., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Zimmermann, W.H., Utikal, J., Wieland, T., Borggrefe, M., Zhou, X. and Akin, I.
Europace 21
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September 2019
Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy.
Lee, J., Termglinchan, V., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Itzhaki, I., Lam, C.K., Garg, P., Lau, E., Greenhaw, M., Seeger, T., Wu, H., Zhang, J.Z, Chen, X., Gil, I.P., Ameen, M., Sallam, K., Rhee, J.W., Churko, J.M., Chaudhary, R., Chour, T., Wang, P.J., Snyder, M.P., Chang, H.Y., Karakikes, I. and Wu, J.C.
Nature 572
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15 August 2019
The translational landscape of the human heart.
van Heesch, S. ORCID: https://orcid.org/0000-0001-9593-1980, Witte, F., Schneider-Lunitz, V. ORCID: https://orcid.org/0000-0002-3980-3789, Schulz, J.F. ORCID: https://orcid.org/0000-0002-8157-2224, Adami, E. ORCID: https://orcid.org/0000-0002-1813-6681, Faber, A. ORCID: https://orcid.org/0000-0003-0178-7653, Kirchner, M. ORCID: https://orcid.org/0000-0002-7049-534X, Maatz, H. ORCID: https://orcid.org/0000-0002-9232-6272, Blachut, S. ORCID: https://orcid.org/0009-0007-0102-9867, Sandmann, C.L. ORCID: https://orcid.org/0000-0002-3847-0708, Kanda, M. ORCID: https://orcid.org/0000-0003-3468-3586, Worth, C.L. ORCID: https://orcid.org/0000-0002-1796-9606, Schafer, S., Calviello, L. ORCID: https://orcid.org/0000-0002-5600-0988, Merriott, R., Patone, G. ORCID: https://orcid.org/0000-0002-7242-0341, Hummel, O. ORCID: https://orcid.org/0009-0000-9986-8333, Wyler, E. ORCID: https://orcid.org/0000-0002-9884-1806, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Mücke, M. ORCID: https://orcid.org/0000-0002-4957-3307, Lindberg, E.L. ORCID: https://orcid.org/0000-0002-2979-433X, Trnka, F., Memczak, S. ORCID: https://orcid.org/0000-0001-9518-7135, Schilling, M. ORCID: https://orcid.org/0000-0002-3453-7792, Felkin, L.E., Barton, P.J.R., Quaife, N.M., Vanezis, K., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Mukai, M., Mah, N. ORCID: https://orcid.org/0000-0002-1240-8076, Oh, S.J., Kurtz, A., Schramm, C., Schwinge, D., Sebode, M., Harakalova, M., Asselbergs, F.W., Vink, A., de Weger, R.A., Viswanathan, S., Widjaja, A.A., Gärtner-Rommel, A., Milting, H., Dos Remedios, C., Knosalla, C., Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Vingron, M., Linke, W.A., Seidman, J.G., Seidman, C.E., Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332, Ohler, U. ORCID: https://orcid.org/0000-0002-0881-3116, Cook, S.A. and Hubner, N. ORCID: https://orcid.org/0000-0002-1218-6223
Cell 178
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27 June 2019
Novel calcineurin A (PPP3CA) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression.
Rydzanicz, M., Wachowska, M., Cook, E.C., Lisowski, P. ORCID: https://orcid.org/0000-0002-3634-1072, Kuźniewska, B., Szymańska, K., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Prigione, A. ORCID: https://orcid.org/0000-0001-9457-1952, Szczałuba, K., Szybińska, A., Koppolu, A., Murcia Pienkowski, V., Kosińska, J., Wiweger, M., Kostrzewa, G., Brzozowska, M., Domańska-Pakieła, D., Jurkiewicz, E., Stawiński, P., Gromadka, A., Zielenkiewicz, P., Demkow, U., Dziembowska, M., Kuźnicki, J., Creamer, T.P. and Płoski, R.
European Journal of Human Genetics 27
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January 2019
2018
Electroconductive biohybrid hydrogel for enhanced maturation and beating properties of engineered cardiac tissues.
Roshanbinfar, K., Vogt, L., Greber, B., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Boccaccini, A.R., Scheibel, T. and Engel, F.B. ORCID: https://orcid.org/0000-0003-2605-3429
Advanced Functional Materials 28
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October 2018
Mutations in disordered regions can cause disease by creating dileucine motifs.
Meyer, K. ORCID: https://orcid.org/0000-0002-8244-6887, Kirchner, M. ORCID: https://orcid.org/0000-0002-7049-534X, Uyar, B. ORCID: https://orcid.org/0000-0002-3170-4890, Cheng, J.Y., Russo, G., Hernandez-Miranda, L.R. ORCID: https://orcid.org/0000-0002-0498-708X, Szymborska, A. ORCID: https://orcid.org/0000-0003-1741-4106, Zauber, H. ORCID: https://orcid.org/0000-0003-2595-1147, Rudolph, I.M. ORCID: https://orcid.org/0000-0002-3903-0755, Willnow, T.E. ORCID: https://orcid.org/0000-0001-9515-7921, Akalin, A. ORCID: https://orcid.org/0000-0002-0468-0117, Haucke, V. ORCID: https://orcid.org/0000-0003-3119-6993, Gerhardt, H. ORCID: https://orcid.org/0000-0002-3030-0384, Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Krauss, M., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Pascual, J.M. and Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751
Cell 175
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20 September 2018
FACT sets a barrier for cell fate reprogramming in Caenorhabditis elegans and human cells.
Kolundzic, E. ORCID: https://orcid.org/0000-0002-7811-3174, Ofenbauer, A. ORCID: https://orcid.org/0000-0003-0379-9105, Bulut, S.I., Uyar, B. ORCID: https://orcid.org/0000-0002-3170-4890, Baytek, G. ORCID: https://orcid.org/0000-0001-9731-9461, Sommermeier, A., Seelk, S. ORCID: https://orcid.org/0000-0002-3525-8859, He, M., Hirsekorn, A., Vucicevic, D. ORCID: https://orcid.org/0000-0002-1162-6709, Akalin, A. ORCID: https://orcid.org/0000-0002-0468-0117, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Lacadie, S.A. ORCID: https://orcid.org/0000-0002-0893-5340 and Tursun, B. ORCID: https://orcid.org/0000-0001-7293-8629
Developmental Cell 46
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10 September 2018
Embryos and embryonic stem cells from the white rhinoceros.
Hildebrandt, T.B., Hermes, R., Colleoni, S., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Holtze, S., Renfree, M.B. ORCID: https://orcid.org/0000-0002-4589-0436, Stejskal, J., Hayashi, K., Drukker, M., Loi, P., Göritz, F., Lazzari, G. and Galli, C. ORCID: https://orcid.org/0000-0002-9529-6136
Nature Communications 9
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4 July 2018
Autologous iPSC-based vaccines elicit anti-tumor responses in vivo.
Kooreman, N.G., Kim, Y., de Almeida, P.E., Termglinchan, V., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Shao, N.Y., Wei, T.T., Yi, H., Dey, De., Nelakanti, R., Brouwer, T.P., Paik, D.T., Sagiv-Barfi, I., Han, A., Quax, P.H.A., Hamming, J.F., Levy, R., Davis, M.M. and Wu, J.C.
Cell Stem Cell 22
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5 April 2018
Human and equine endothelial cells in a live cell imaging scratch assay in vitro.
Rieger, J., Hopperdietzel, C., Kaessmeyer, S., Slosarek, I., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Richardson, K. and Plendl, J.
Clinical Hemorheology and Microcirculation 70
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2018
2017
Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods.
Churko, J.M., Lee, J., Ameen, M., Gu, M., Venkatasubramanian, M., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Sallam, K., Im, H., Wang, G., Gold, J.D., Salomonis, N., Snyder, M.P. and Wu, J.C.
Nature Biomedical Engineering 1
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October 2017
Alloimmune responses of humanized mice to human pluripotent stem cell therapeutics.
Kooreman, N.G., de Almeida, P.E., Stack, J.P., Nelakanti, R.V., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Shao, N.Y., Swijnenburg, R.J., Sanchez-Freire, V., Matsa, E., Liu, C., Connolly, A.J., Hamming, J.F., Quax, P.H.A., Brehm, M.A., Greiner, D.L., Shultz, L.D. and Wu, J.C.
Cell Reports 20
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22 August 2017
A comprehensive TALEN-based knockout library for generating human induced pluripotent stem cell-based models for cardiovascular diseases.
Karakikes, I., Termglinchan, V., Cepeda, D.A., Lee, J., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Hendel, A., Itzhaki, I., Ameen, M., Shrestha, R., Wu, H., Ma, N., Shao, N.Y., Seeger, T., Woo, N.A., Wilson, K.D., Matsa, E., Porteus, M.H., Sebastiano, V. and Wu, J.C.
Circulation Research 120
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12 May 2017
2016
Generation of functional cardiomyocytes from the synoviocytes of patients with rheumatoid arthritis via induced pluripotent stem cells.
Lee, J., Jung, S.M., Ebert, A.D., Wu, H., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Kim, Y., Yi, H., Park, S.H. and Ju, J.H.
Scientific Reports 6
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9 September 2016
Rewinding the process of mammalian extinction.
Saragusty, J., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Drukker, M., Durrant, B., Friedrich Ben-Nun, I., Galli, C., Goeritz, F., Hayashi, K., Hermes, R., Holtze, S., Johnson, S., Lazzari, G., Loi, P., Loring, J.F., Okita, K., Renfree, M.B., Seet, S., Voracek, T., Stejskal, J., Ryder, O.A. and Hildebrandt, T.B.
Zoo Biology 35
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July 2016
Modeling cardiovascular diseases with patient-specific human pluripotent stem cell-derived cardiomyocytes.
Burridge, P.W., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Matsa, E., Sharma, A., Wu, H. and Wu, J.C.
Methods in Molecular Biology 1353
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2016
2015
Microfluidic single-cell analysis of transplanted human induced pluripotent stem cell-derived cardiomyocytes after acute myocardial infarction.
Ong, S.G., Huber, B.C., Lee, W.H., Kodo, K., Ebert, A.D., Ma, Y., Nguyen, P.K., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Chen, W.Y. and Wu, J.C.
Circulation 132
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25 August 2015
Reprogramming and transdifferentiation for cardiovascular development and regenerative medicine: where do we stand?
Ebert, A.D., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Chen, I.Y. and Wu, J.C.
EMBO Molecular Medicine 7
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16 July 2015
Pravastatin reverses obesity-induced dysfunction of induced pluripotent stem cell-derived endothelial cells via a nitric oxide-dependent mechanism.
Gu, M., Mordwinkin, N.M., Kooreman, N.G., Lee, J., Wu, H., Hu, S., Churko, J.M., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Burridge, P.W., He, C., Barron, F.E., Ong, S.G., Gold, J.D. and Wu, J.C
European Heart Journal 36
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1 April 2015
Improved approach for chondrogenic differentiation of human induced pluripotent stem cells.
Nejadnik, H., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Lenkov, O.D., Chapelin, F., Donig, J., Tong, X., Derugin, N., Chan, R.C.F., Gaur, A., Yang, F., Wu, J.C. and Daldrup-Link, H.E.
Stem Cell Reviews and Reports 11
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April 2015
2014
Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system.
Ebert, A.D., Kodo, K., Liang, P., Wu, H., Huber, B.C., Riegler, J., Churko, J., Lee, J., de Almeida, P., Lan, F., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Burridge, P.W., Gold, J.D., Mochly-Rosen, D. and Wu, J.C.
Science Translational Medicine 6
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24 September 2014
Recent technological updates and clinical applications of induced pluripotent stem cells.
Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Jung, S.M., Lee, J. and Ju, J.H.
Korean Journal of Internal Medicine 29
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September 2014
Human induced pluripotent stem cell-derived cardiomyocytes as an in vitro model for coxsackievirus B3-induced myocarditis and antiviral drug screening platform.
Sharma, A., Marceau, C., Hamaguchi, R., Burridge, P.W., Rajarajan, K., Churko, J.M., Wu, H., Sallam, K.I., Matsa, E., Sturzu, A.C., Che, Y., Ebert, A., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Liang, P., Red-Horse, K., Carette, J.E., Wu, S.M. and Wu, J.C.
Circulation Research 115
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29 August 2014
Chemically defined generation of human cardiomyocytes.
Burridge, P.W., Matsa, E., Shukla, P., Lin, Z.C., Churko, J.M., Ebert, A.D., Lan, F., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Huber, B., Mordwinkin, N.M., Plews, J.R., Abilez, O.J., Cui, B., Gold, J.D. and Wu, J.C.
Nature Methods 11
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August 2014
Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance.
de Almeida, P.E., Meyer, E.H., Kooreman, N.G., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Dey, D., Sanchez-Freire, V., Hu, S., Ebert, A., Odegaard, J., Mordwinkin, N.M., Brouwer, T.P., Lo, D., Montoro, D.T., Longaker, M.T., Negrin, R.S. and Wu, J.C.
Nature Communications 5
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30 May 2014
Generation of disease-specific induced pluripotent stem cells from patients with rheumatoid arthritis and osteoarthritis.
Lee, J., Kim, Y., Yi, H., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Kim, J., Jung, H., Rim, Y.A., Jung, S.M., Kim, M., Kim, Y.G., Park, S.H., Kim, H.Y. and Ju, J.H.
Arthritis Research & Therapy 16
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4 February 2014
Second generation codon optimized minicircle (CoMiC) for nonviral reprogramming of human adult fibroblasts.
Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Lisowski, L., Kooreman, N.G. and Wu, J.C.
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2013
Costimulation-adhesion blockade is superior to cyclosporine A and prednisone immunosuppressive therapy for preventing rejection of differentiated human embryonic stem cells following transplantation.
Huber, B.C., Ransohoff, J.D., Ransohoff, K.J., Riegler, J., Ebert, A., Kodo, K., Gong, Y., Sanchez-Freire, V., Dey, D., Kooreman, N.G., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Zhang, W.Y., Odegaard, J., Hu, S., Gold, J.D., Robbins, R.C. and Wu, J.C.
Stem Cells 31
(11): 2354-63.
November 2013
The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells.
Sharma, A., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Zhang, W.Y., Lan, F., He, C., Mordwinkin, N.M., Chua, K.F. and Wu, J.C.
Journal of Biological Chemistry 288
(25): 18439-47.
21 June 2013
Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity.
Liang, P., Lan, F., Lee, A.S., Gong, T., Sanchez-Freire, V., Wang, Y., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Sallam, K., Knowles, J.W., Wang, P.J., Nguyen, P.K., Bers, D.M., Robbins, R.C. and Wu, J.C.
Circulation 127
(16): 1677-91.
23 April 2013
This list was generated on Mon Jun 22 10:54:02 2026 UTC.
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