Article

Natural killer cell immunotherapy reverses lung fibrosis by eliminating senescent fibroblasts.
Merkt, Wolfgang ORCID: https://orcid.org/0000-0002-3108-154X, Rodon, Lea ORCID: https://orcid.org/0009-0004-7774-9690, Deicher, Franca S. ORCID: https://orcid.org/0009-0009-9624-1653, Freitag, Merle, Claus, Maren ORCID: https://orcid.org/0000-0001-8732-0645, Lister, Rachael, Han, Hongwei ORCID: https://orcid.org/0000-0002-0190-4461, Zhou, Yan ORCID: https://orcid.org/0000-0002-8822-5276, Horne, Arik ORCID: https://orcid.org/0000-0002-4209-4573, Stütz, Ayla ORCID: https://orcid.org/0009-0004-9123-4044, Li, Yi-Nan ORCID: https://orcid.org/0000-0001-8934-9361, Kreuter, Michael, Kahn, Nicolas ORCID: https://orcid.org/0000-0002-5403-8069, Schneider, Marc A. ORCID: https://orcid.org/0000-0001-8269-3821, Egea-Zorrilla, Alejandro ORCID: https://orcid.org/0000-0002-5522-8227, Blasco-Iturri, Zuriñe, Nikulina, Nadezhda ORCID: https://orcid.org/0009-0001-2533-0984, Turkowski, Kati ORCID: https://orcid.org/0000-0002-8455-8268, Ruppert, Clemens ORCID: https://orcid.org/0000-0002-0938-2469, Guenther, Andreas ORCID: https://orcid.org/0000-0002-2187-0975, Rizzo, Roberta ORCID: https://orcid.org/0000-0001-9507-9126, Rizzo, Sabrina, Ferraresi, Matteo, Hübschmann, Daniel ORCID: https://orcid.org/0000-0002-6041-7049, Haas, Simon ORCID: https://orcid.org/0000-0001-9227-2051, Blank, Norbert ORCID: https://orcid.org/0000-0002-9419-1690, Watzl, Carsten ORCID: https://orcid.org/0000-0001-5195-0995, Tykocinski, Lars-Oliver ORCID: https://orcid.org/0000-0002-7645-1559, Lorenz, Hanns-Martin ORCID: https://orcid.org/0000-0001-8197-8681, Savai, Rajkumar ORCID: https://orcid.org/0000-0003-1538-2091, Pardo-Saganta, Ana ORCID: https://orcid.org/0000-0002-5926-6255 and Lagares, David ORCID: https://orcid.org/0000-0002-7317-8796
Science Translational Medicine 18 (849): eadq5442. May 2026

Foldamers rescue synucleinopathy phenotypes in multiple in vitro and in vivo models.
Dohoney, Ryan A. ORCID: https://orcid.org/0000-0002-0190-8665, Palanikumar, L. ORCID: https://orcid.org/0000-0002-2639-0436, Oldani, Emily ORCID: https://orcid.org/0009-0006-5430-0270, Baysah, Charles Zuwu ORCID: https://orcid.org/0000-0003-0657-0461, Joseph, Johnson A. ORCID: https://orcid.org/0000-0002-0415-3122, Polanco, David ORCID: https://orcid.org/0000-0002-0005-6712, Santos-Otte, Paula ORCID: https://orcid.org/0009-0009-4556-0574, Stillman, Nicholas H. ORCID: https://orcid.org/0000-0002-8353-7684, Corcoran, Peter, Ball, Tyler D. ORCID: https://orcid.org/0000-0001-9602-0329, Fitch, Tessa C., Ahmed, Jemil, Ogbonna-Ukuku, Ifunayachi ORCID: https://orcid.org/0009-0001-3818-5421, Reynolds Caicedo, Kevin M. ORCID: https://orcid.org/0009-0000-4688-0144, Liu, Ying, Leehey, Maureen A., Linseman, Daniel A. ORCID: https://orcid.org/0000-0001-8774-1976, Paredes, Daniel A. ORCID: https://orcid.org/0000-0002-9635-8001, Birol, Melissa ORCID: https://orcid.org/0000-0003-3397-8446, Cremades, Nunilo ORCID: https://orcid.org/0000-0002-9138-6687, Magzoub, Mazin ORCID: https://orcid.org/0000-0003-3414-6617 and Kumar, Sunil ORCID: https://orcid.org/0000-0001-5472-4619
Science Translational Medicine 18 (843): eadu1050. 1 April 2026

Aberrant bone marrow granulopoiesis generates neutrophils that promote B cell activity in neuromyelitis optica spectrum disorder.
Li, Handong ORCID: https://orcid.org/0009-0005-7946-9630, Zhang, Wenyan ORCID: https://orcid.org/0009-0006-6089-5944, Li, Ting ORCID: https://orcid.org/0009-0004-5677-9882, Miao, Yuyang, Yang, Chunsheng ORCID: https://orcid.org/0000-0003-0846-2851, Jin, Han, Ruan, Zhe ORCID: https://orcid.org/0000-0002-8190-4022, Tian, Decai ORCID: https://orcid.org/0000-0002-5153-2491, Yin, Tingyu, Qi, Caiyun ORCID: https://orcid.org/0009-0001-0049-5045, Xu, Tongxiao, He, Wenyan ORCID: https://orcid.org/0000-0002-8752-4768, Zhang, Meini, Zhou, Jie ORCID: https://orcid.org/0000-0001-5964-1599, Paul, Friedemann ORCID: https://orcid.org/0000-0002-6378-0070, Chang, Ting ORCID: https://orcid.org/0000-0002-7546-8017 and Liu, Qiang ORCID: https://orcid.org/0000-0002-6621-0591
Science Translational Medicine 18 (840): eaeb4775. March 2026

Epithelial OPA1 links mitochondrial fusion to inflammatory bowel disease.
Bao, L.L. ORCID: https://orcid.org/0009-0003-3081-7062, Yu, Y.Q. ORCID: https://orcid.org/0000-0002-4847-8877, González-Acera, M. ORCID: https://orcid.org/0009-0008-9445-5650, Patankar, J.V. ORCID: https://orcid.org/0000-0002-1884-7424, Giessl, A. ORCID: https://orcid.org/0000-0002-9768-2049, Sturm, G. ORCID: https://orcid.org/0000-0001-9584-7842, Kühl, A.A. ORCID: https://orcid.org/0000-0003-2293-5387, Atreya, R. ORCID: https://orcid.org/0000-0002-8556-8433, Erkert, L., Gámez-Belmonte, R. ORCID: https://orcid.org/0000-0002-7159-8957, Krug, S.M. ORCID: https://orcid.org/0000-0002-1293-2484, Schmid, B. ORCID: https://orcid.org/0000-0002-9327-2296, Tripal, P., Chiriac, M.T., Hildner, K., Siegmund, B. ORCID: https://orcid.org/0000-0002-0055-958X, Wirtz, S. ORCID: https://orcid.org/0000-0001-6936-7431, Stürzl, M. ORCID: https://orcid.org/0000-0002-9276-2824, Mohamed Abdou, M. ORCID: https://orcid.org/0009-0002-7352-166X, Trajanoski, Z. ORCID: https://orcid.org/0000-0002-0636-7351, Neurath, M.F. ORCID: https://orcid.org/0000-0003-4344-1474, Zorzano, A. ORCID: https://orcid.org/0000-0002-1638-0306 and Becker, C. ORCID: https://orcid.org/0000-0002-1388-1041
Science Translational Medicine 17 (781): eadn8699. January 2025

Increased β(2)-adrenergic signaling promotes fracture healing through callus neovascularization in mice.
Jahn, D. ORCID: https://orcid.org/0000-0001-8912-5851, Knapstein, P.R. ORCID: https://orcid.org/0000-0002-4039-6674, Otto, E., Köhli, P. ORCID: https://orcid.org/0000-0001-7473-6553, Sevecke, J. ORCID: https://orcid.org/0009-0001-1016-3482, Graef, F. ORCID: https://orcid.org/0000-0002-0435-9059, Graffmann, C. ORCID: https://orcid.org/0009-0004-2423-8141, Fuchs, M., Jiang, S. ORCID: https://orcid.org/0000-0002-1545-2152, Rickert, M., Erdmann, C., Appelt, J. ORCID: https://orcid.org/0000-0001-6351-9959, Revend, L., Küttner, Q., Witte, J., Rahmani, A., Duda, G. ORCID: https://orcid.org/0000-0001-7605-3908, Xie, W. ORCID: https://orcid.org/0000-0002-1404-793X, Donat, A. ORCID: https://orcid.org/0000-0003-3069-0199, Schinke, T., Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, Tchouto, M.N., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Frosch, K.H., Baranowsky, A. ORCID: https://orcid.org/0009-0007-3883-646X, Tsitsilonis, S. and Keller, J. ORCID: https://orcid.org/0000-0002-8925-7288
Science Translational Medicine 16 (743): eadk9129. 17 April 2024

Multiple sclerosis endophenotypes identified by high-dimensional blood signatures are associated with distinct disease trajectories.
Gross, C.C. ORCID: https://orcid.org/0000-0002-4872-9189, Schulte-Mecklenbeck, A. ORCID: https://orcid.org/0000-0003-3855-4706, Steinberg, O.V. ORCID: https://orcid.org/0009-0000-7370-6811, Wirth, T. ORCID: https://orcid.org/0000-0002-0102-4608, Lauks, S. ORCID: https://orcid.org/0009-0008-4151-0003, Bittner, S. ORCID: https://orcid.org/0000-0003-2179-3655, Schindler, P. ORCID: https://orcid.org/0000-0002-8846-121X, Baranzini, S.E. ORCID: https://orcid.org/0000-0003-0067-194X, Groppa, S. ORCID: https://orcid.org/0000-0002-2551-5655, Bellmann-Strobl, J. ORCID: https://orcid.org/0000-0003-2615-1643, Bünger, N. ORCID: https://orcid.org/0009-0000-3821-5187, Chien, C. ORCID: https://orcid.org/0000-0001-8280-9513, Dawin, E. ORCID: https://orcid.org/0000-0002-4755-1534, Eveslage, M. ORCID: https://orcid.org/0000-0002-8802-1134, Fleischer, V. ORCID: https://orcid.org/0000-0002-3293-5121, Gonzalez-Escamilla, G. ORCID: https://orcid.org/0000-0002-7209-1736, Gisevius, B., Haas, J. ORCID: https://orcid.org/0000-0002-2314-7465, Kerschensteiner, M. ORCID: https://orcid.org/0000-0003-4898-9383, Kirstein, L., Korsukewitz, C., Lohmann, L. ORCID: https://orcid.org/0000-0003-4911-6883, Lünemann, J.D. ORCID: https://orcid.org/0000-0002-3007-708X, Luessi, F. ORCID: https://orcid.org/0000-0003-4334-4199, Meyer Zu Hörste, G. ORCID: https://orcid.org/0000-0002-4341-4719, Motte, J. ORCID: https://orcid.org/0000-0002-6624-8565, Ruck, T. ORCID: https://orcid.org/0000-0001-6332-8650, Ruprecht, K. ORCID: https://orcid.org/0000-0003-1962-6014, Schwab, N. ORCID: https://orcid.org/0000-0001-5494-9885, Steffen, F. ORCID: https://orcid.org/0000-0003-3708-8600, Meuth, S.G. ORCID: https://orcid.org/0000-0003-2571-3501, Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070, Wildemann, B., Kümpfel, T. ORCID: https://orcid.org/0000-0001-7509-5268, Gold, R. ORCID: https://orcid.org/0000-0002-7223-3052, Hahn, T. ORCID: https://orcid.org/0000-0001-6541-3795, Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928, Klotz, L. ORCID: https://orcid.org/0000-0001-5439-9633 and Wiendl, H. ORCID: https://orcid.org/0000-0003-4310-3432
Science Translational Medicine 16 (740): eade8560. March 2024

Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment.
Lechner, L. ORCID: https://orcid.org/0000-0002-9318-6857, Opitz, R. ORCID: https://orcid.org/0000-0003-3143-0997, Silver, M.J. ORCID: https://orcid.org/0000-0002-3852-9677, Krabusch, P.M., Prentice, A.M. ORCID: https://orcid.org/0000-0001-5389-451X, Field, M.S., Stachelscheid, H. ORCID: https://orcid.org/0000-0002-9283-4605, Leitão, E. ORCID: https://orcid.org/0000-0001-5051-9714, Schröder, C., Fernandez Vallone, V. ORCID: https://orcid.org/0000-0003-3875-9170, Horsthemke, B., Jöckel, K.H. ORCID: https://orcid.org/0000-0002-1987-0255, Schmidt, B., Nöthen, M.M. ORCID: https://orcid.org/0000-0002-8770-2464, Hoffmann, P. ORCID: https://orcid.org/0000-0002-6573-983X, Herms, S. ORCID: https://orcid.org/0000-0002-2786-8200, Kleyn, P.W. ORCID: https://orcid.org/0000-0002-6249-8196, Megges, M. ORCID: https://orcid.org/0000-0001-6537-0975, Blume-Peytavi, U. ORCID: https://orcid.org/0000-0003-3528-3752, Weiss, K. ORCID: https://orcid.org/0000-0002-0658-8074, Mai, K., Blankenstein, O. ORCID: https://orcid.org/0000-0003-1803-5589, Obermayer, B. ORCID: https://orcid.org/0000-0002-9116-630X, Wiegand, S. ORCID: https://orcid.org/0000-0001-8341-9533 and Kühnen, P. ORCID: https://orcid.org/0000-0003-0211-176X
Science Translational Medicine 15 (705): eadg1659. July 2023

Therapeutic inhibition of RBM20 improves diastolic function in a murine heart failure model and human engineered heart tissue.
Radke, M.H. ORCID: https://orcid.org/0000-0003-0112-9917, Badillo-Lisakowski, V. ORCID: https://orcid.org/0000-0001-5906-2589, Britto-Borges, T. ORCID: https://orcid.org/0000-0002-6218-4429, Kubli, D.A. ORCID: https://orcid.org/0000-0001-7970-4075, Jüttner, R. ORCID: https://orcid.org/0000-0003-3565-0698, Parakkat, P. ORCID: https://orcid.org/0000-0003-2691-791X, Lopez Carballo, J. ORCID: https://orcid.org/0000-0002-7735-7185, Hüttemeister, J., Liss, M. ORCID: https://orcid.org/0000-0002-0585-7850, Hansen, A., Dieterich, C. ORCID: https://orcid.org/0000-0001-9468-6311, Mullick, A.E. ORCID: https://orcid.org/0000-0003-4600-961X and Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172
Science Translational Medicine 13 (622): eabe8952. December 2021

Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations.
Fomin, A. ORCID: https://orcid.org/0000-0001-5578-6977, Gärtner, A. ORCID: https://orcid.org/0000-0001-6899-7693, Cyganek, L. ORCID: https://orcid.org/0000-0001-9120-1382, Tiburcy, M. ORCID: https://orcid.org/0000-0002-6942-6275, Tuleta, I., Wellers, L., Folsche, L. ORCID: https://orcid.org/0000-0003-3752-170X, Hobbach, A.J. ORCID: https://orcid.org/0000-0001-6421-8429, von Frieling-Salewsky, M., Unger, A., Hucke, A. ORCID: https://orcid.org/0000-0002-2044-2602, Koser, F., Kassner, A., Sielemann, K. ORCID: https://orcid.org/0000-0002-4022-8531, Streckfuß-Bömeke, K. ORCID: https://orcid.org/0000-0001-5137-7228, Hasenfuss, G. ORCID: https://orcid.org/0000-0002-5942-361X, Goedel, A. ORCID: https://orcid.org/0000-0002-5980-2257, Laugwitz, K.L., Moretti, A. ORCID: https://orcid.org/0000-0001-5782-7832, Gummert, J.F., Dos Remedios, C.G. ORCID: https://orcid.org/0000-0003-1052-7490, Reinecke, H. ORCID: https://orcid.org/0000-0002-4515-1609, Knöll, R. ORCID: https://orcid.org/0000-0001-8871-112X, van Heesch, S. ORCID: https://orcid.org/0000-0001-9593-1980, Hubner, N. ORCID: https://orcid.org/0000-0002-1218-6223, Zimmermann, W.H. ORCID: https://orcid.org/0000-0003-1190-4040, Milting, H. ORCID: https://orcid.org/0000-0001-9722-0007 and Linke, W.A. ORCID: https://orcid.org/0000-0003-0801-3773
Science Translational Medicine 13 (618): eabd3079. 3 November 2021

PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity.
Kim, H., Kim, H., Feng, Y., Li, Y., Tamiya, H., Tocci, S. and Ronai, Z.A.
Science Translational Medicine 12 (551): eaaz5683. 8 July 2020

The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice.
Murthy, S.E., Loud, M.C., Daou, I., Marshall, K.L., Schwaller, F. ORCID: https://orcid.org/0000-0002-7685-5537, Kühnemund, J., Francisco, A.G., Keenan, W.T., Dubin, A.E., Lewin, G.R. ORCID: https://orcid.org/0000-0002-2890-6352 and Patapoutian, A.
Science Translational Medicine 10 (462): eaat9897. 10 October 2018

High-throughput metabolomic analysis predicts mode of action of uncharacterized antimicrobial compounds.
Zampieri, M., Szappanos, B., Buchieri, M.V., Trauner, A., Piazza, I. ORCID: https://orcid.org/0000-0001-5895-6134, Picotti, P., Gagneux, S., Borrell, S., Gicquel, B., Lelievre, J., Papp, B. and Sauer, U.
Science Translational Medicine 10 (429): eaal3973. 21 February 2018

Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors.
Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Reed, C., Jiang, E., Garcia, H.D., von Stebut, J., MacArthur, I.C., Hundsdoerfer, P., Kim, J.H., de Stanchina, E., Kuwahara, Y., Hosoi, H., Ganem, N.J., Dela Cruz, F., Kung, A.L., Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Petrini, J.H. and Kentsis, A.
Science Translational Medicine 9 (414): eaam9078. 1 November 2017

Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease.
Roberts, A.M., Ware, J.S., Herman, D.S., Schafer, S., Baksi, J., Bick, A.G., Buchan, R.J., Walsh, R., John, S., Wilkinson, S., Mazzarotto, F., Felkin, L.E., Gong, S., MacArthur, J.A.L., Cunningham, F., Flannick, J., Gabriel, S.B., Altshuler, D.M., Macdonald, P.S., Heinig, M. ORCID: https://orcid.org/0000-0002-5612-1720, Keogh, A.M., Hayward, C.S., Banner, N.R., Pennell, D.J., O'Regan, D.P., San, T.R., de Marvao, A., Dawes, T.J.W., Gulati, A., Birks, E.J., Yacoub, M.H., Radke, M. ORCID: https://orcid.org/0000-0003-0112-9917, Gotthardt, M. ORCID: https://orcid.org/0000-0003-1788-3172, Wilson, J.G., O'Donnell, C.J., Prasad, S.K., Barton, P.J.R., Fatkin, D., Hubner, N. ORCID: https://orcid.org/0000-0002-1218-6223, Seidman, J.G., Seidman, C.E. and Cook, S.A.
Science Translational Medicine 7 (270): 270ra6. 14 January 2015

Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system.
Ebert, A.D., Kodo, K., Liang, P., Wu, H., Huber, B.C., Riegler, J., Churko, J., Lee, J., de Almeida, P., Lan, F., Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Burridge, P.W., Gold, J.D., Mochly-Rosen, D. and Wu, J.C.
Science Translational Medicine 6 (255): 255ra130. 24 September 2014

Effective diagnosis of genetic disease by computational phenotype analysis of the disease-associated genome.
Zemojtel, T., Koehler, S., Mackenroth, L., Jaeger, M., Hecht, J., Krawitz, P. ORCID: https://orcid.org/0000-0002-3194-8625, Graul-Neumann, L., Doelken, S., Ehmke, N., Spielmann, M., Oien, N.C., Schweiger, M.R., Krueger, U., Frommer, G., Fischer, B., Kornak, U., Floettmann, R., Ardeshirdavani, A., Moreau, Y., Lewis, S.E., Haendel, M., Smedley, D., Horn, D., Mundlos, S. and Robinson, P.N.
Science Translational Medicine 6 (252): 252ra123. 3 September 2014

Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation.
Caglayan, S., Takagi-Niidome, S., Liao, F., Carlo, A.S., Schmidt, V. ORCID: https://orcid.org/0000-0002-5851-1087, Burgert, T., Kitago, Y., Füchtbauer, E.M., Füchtbauer, A., Holtzman, D.M., Takagi, J. and Willnow, T.E. ORCID: https://orcid.org/0000-0001-9515-7921
Science Translational Medicine 6 (223): 223ra20. 12 February 2014

A genomics-based classification of human lung tumors.

Science Translational Medicine 5 (209): 209ra153. 30 October 2013

TCR-ligand k(off) rate correlates with the protective capacity of antigen-specific CD8(+) T cells for adoptive transfer.
Nauerth, M., Weissbrich, B., Knall, R., Franz, T., Dössinger, G., Bet, J., Paszkiewicz, P.J., Pfeifer, L., Bunse, M. ORCID: https://orcid.org/0000-0002-7554-2520, Uckert, W., Holtappels, R., Gillert-Marien, D., Neuenhahn, M., Krackhardt, A., Reddehase, M.J., Riddell, S.R. and Busch, D.H.
Science Translational Medicine 5 (192): 192ra87. 3 July 2013

Quantitative image analysis of cellular heterogeneity in breast tumors complements genomic profiling.
Yuan, Y., Failmezger, H., Rueda, O.M., Ali, H.R., Graef, S., Chin, S.F., Schwarz, R.F. ORCID: https://orcid.org/0000-0001-9155-4268, Curtis, C., Dunning, M.J., Bardwell, H., Johnson, N., Doyle, S., Turashvili, G., Provenzano, E., Aparicio, S., Caldas, C. and Markowetz, F.
Science Translational Medicine 4 (157): 157ra143. 24 October 2012

Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer.
Weiss, J., Sos, M.L., Seidel, D., Peifer, M., Zander, T., Heuckmann, J.M., Ullrich, R.T., Menon, R., Maier, S., Soltermann, A., Moch, H., Wagener, P., Fischer, F., Heynck, S., Koker, M., Schöttle, J., Leenders, F., Gabler, F., Dabow, I., Querings, S., Heukamp, L.C., Balke-Want, H., Ansén, S., Rauh, D., Baessmann, I., Altmüller, J. ORCID: https://orcid.org/0000-0003-4372-1521, Wainer, Z., Conron, M., Wright, G., Russell, P., Solomon, B., Brambilla, E., Brambilla, C., Lorimier, P., Sollberg, S., Brustugun, O.T., Engel-Riedel, W., Ludwig, C., Petersen, I., Sänger, J., Clement, J., Groen, H., Timens, W., Sietsma, H., Thunnissen, E., Smit, E., Heideman, D., Cappuzzo, F., Ligorio, C., Damiani, S., Hallek, M., Beroukhim, R., Pao, W., Klebl, B., Baumann, M., Buettner, R., Ernestus, K., Stoelben, E., Wolf, J., Nürnberg, P., Perner, S. and Thomas, R.K
Science Translational Medicine 2 (62): 62ra93. 15 December 2010