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PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity.
Kim, H. and Kim, H. and Feng, Y. and Li, Y. and Tamiya, H. and Tocci, S. and Ronai, Z.A.
Science Translational Medicine 12 (551): eaaz5683. 8 July 2020


The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice.
Murthy, S.E. and Loud, M.C. and Daou, I. and Marshall, K.L. and Schwaller, F. and Kühnemund, J. and Francisco, A.G. and Keenan, W.T. and Dubin, A.E. and Lewin, G.R. and Patapoutian, A.
Science Translational Medicine 10 (462): eaat9897. 10 October 2018

High-throughput metabolomic analysis predicts mode of action of uncharacterized antimicrobial compounds.
Zampieri, M. and Szappanos, B. and Buchieri, M.V. and Trauner, A. and Piazza, I. and Picotti, P. and Gagneux, S. and Borrell, S. and Gicquel, B. and Lelievre, J. and Papp, B. and Sauer, U.
Science Translational Medicine 10 (429): eaal3973. 21 February 2018


Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors.
Henssen, A.G. and Reed, C. and Jiang, E. and Garcia, H.D. and von Stebut, J. and MacArthur, I.C. and Hundsdoerfer, P. and Kim, J.H. and de Stanchina, E. and Kuwahara, Y. and Hosoi, H. and Ganem, N.J. and Dela Cruz, F. and Kung, A.L. and Schulte, J.H. and Petrini, J.H. and Kentsis, A.
Science Translational Medicine 9 (414): eaam9078. 1 November 2017


Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease.
Roberts, A.M. and Ware, J.S. and Herman, D.S. and Schafer, S. and Baksi, J. and Bick, A.G. and Buchan, R.J. and Walsh, R. and John, S. and Wilkinson, S. and Mazzarotto, F. and Felkin, L.E. and Gong, S. and MacArthur, J.A.L. and Cunningham, F. and Flannick, J. and Gabriel, S.B. and Altshuler, D.M. and Macdonald, P.S. and Heinig, M. and Keogh, A.M. and Hayward, C.S. and Banner, N.R. and Pennell, D.J. and O'Regan, D.P. and San, T.R. and de Marvao, A. and Dawes, T.J.W. and Gulati, A. and Birks, E.J. and Yacoub, M.H. and Radke, M. and Gotthardt, M. and Wilson, J.G. and O'Donnell, C.J. and Prasad, S.K. and Barton, P.J.R. and Fatkin, D. and Hubner, N. and Seidman, J.G. and Seidman, C.E. and Cook, S.A.
Science Translational Medicine 7 (270): 270ra6. 14 January 2015


Effective diagnosis of genetic disease by computational phenotype analysis of the disease-associated genome.
Zemojtel, T. and Koehler, S. and Mackenroth, L. and Jaeger, M. and Hecht, J. and Krawitz, P. and Graul-Neumann, L. and Doelken, S. and Ehmke, N. and Spielmann, M. and Oien, N.C. and Schweiger, M.R. and Krueger, U. and Frommer, G. and Fischer, B. and Kornak, U. and Floettmann, R. and Ardeshirdavani, A. and Moreau, Y. and Lewis, S.E. and Haendel, M. and Smedley, D. and Horn, D. and Mundlos, S. and Robinson, P.N.
Science Translational Medicine 6 (252): 252ra123. 3 September 2014

Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation.
Caglayan, S. and Takagi-Niidome, S. and Liao, F. and Carlo, A.S. and Schmidt, V. and Burgert, T. and Kitago, Y. and Füchtbauer, E.M. and Füchtbauer, A. and Holtzman, D.M. and Takagi, J. and Willnow, T.E.
Science Translational Medicine 6 (223): 223ra20. 12 February 2014


TCR-ligand k(off) rate correlates with the protective capacity of antigen-specific CD8(+) T cells for adoptive transfer.
Nauerth, M. and Weissbrich, B. and Knall, R. and Franz, T. and Dössinger, G. and Bet, J. and Paszkiewicz, P.J. and Pfeifer, L. and Bunse, M. and Uckert, W. and Holtappels, R. and Gillert-Marien, D. and Neuenhahn, M. and Krackhardt, A. and Reddehase, M.J. and Riddell, S.R. and Busch, D.H.
Science Translational Medicine 5 (192): 192ra87. 3 July 2013


Quantitative image analysis of cellular heterogeneity in breast tumors complements genomic profiling.
Yuan, Y. and Failmezger, H. and Rueda, O.M. and Ali, H.R. and Graef, S. and Chin, S.F. and Schwarz, R.F. and Curtis, C. and Dunning, M.J. and Bardwell, H. and Johnson, N. and Doyle, S. and Turashvili, G. and Provenzano, E. and Aparicio, S. and Caldas, C. and Markowetz, F.
Science Translational Medicine 4 (157): 157ra143. 24 October 2012

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