Article

Somatosensory input drives membrane potential dynamics in motor cortex during voluntary limb movement.
Voigt, Birgit C. ORCID: https://orcid.org/0000-0002-2520-0178, Rau, Florian ORCID: https://orcid.org/0000-0002-4685-9473, Estebanez, Luc ORCID: https://orcid.org/0000-0001-6253-7637 and Poulet, James F.A. ORCID: https://orcid.org/0000-0003-0296-5415
PLoS Biology 24 (4): e3003749. April 2026

Spontaneous single-nucleotide substitutions and microsatellite mutations have distinct distributions of fitness effects.
Plavskin, Y. ORCID: https://orcid.org/0000-0002-6911-3009, de Biase, M.S. ORCID: https://orcid.org/0000-0003-0383-5161, Ziv, N., Janská, L., Zhu, Y.O., Hall, D.W., Schwarz, R.F. ORCID: https://orcid.org/0000-0001-9155-4268, Tranchina, D. and Siegal, M.L. ORCID: https://orcid.org/0000-0001-6930-2988
PLoS Biology 22 (7): e3002698. 1 July 2024

The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions.
Fasciani, I., Petragnano, F., Wang, Z. ORCID: https://orcid.org/0009-0000-0062-7119, Edwards, R., Telugu, N. ORCID: https://orcid.org/0000-0003-4509-7056, Pietrantoni, I., Zabel, U., Zauber, H. ORCID: https://orcid.org/0000-0003-2595-1147, Grieben, M., Terzenidou, M.E., Di Gregorio, J., Pellegrini, C., Santini, S., Taddei, A.R., Pohl, B., Aringhieri, S., Carli, M., Aloisi, G., Marampon, F., Charlesworth, E., Roman, A. ORCID: https://orcid.org/0000-0001-9440-9752, Diecke, S. ORCID: https://orcid.org/0000-0002-5219-5992, Flati, V., Giorgi, F., Amicarelli, F., Tobin, A.B., Scarselli, M., Tokatlidis, K., Rossi, M., Lohse, M.J. ORCID: https://orcid.org/0000-0002-0599-3510, Annibale, P. ORCID: https://orcid.org/0000-0003-3208-5347 and Maggio, R. ORCID: https://orcid.org/0000-0003-4436-2356
PLoS Biology 22 (4): e3002582. 29 April 2024

A new human embryonic cell type associated with activity of young transposable elements allows definition of the inner cell mass.
Singh, M. ORCID: https://orcid.org/0000-0002-8626-5418, Kondrashkina, A. ORCID: https://orcid.org/0000-0001-9065-7177, Widmann, T.J., Cortes, J.L., Bansal, V. ORCID: https://orcid.org/0000-0002-0944-7226, Wang, J. ORCID: https://orcid.org/0000-0002-7027-0298, Römer, C., Garcia-Canadas, M., Garcia-Perez, J.L., Hurst, L.D. and Izsvak, Z. ORCID: https://orcid.org/0000-0002-2053-2384
PLoS Biology 21 (6): e3002162. 20 June 2023

The synaptic scaffold protein MPP2 interacts with GABA(A) receptors at the periphery of the postsynaptic density of glutamatergic synapses.
Schmerl, B., Gimber, N. ORCID: https://orcid.org/0000-0001-9456-3063, Kuropka, B., Stumpf, A., Rentsch, J., Kunde, S.A., von Sivers, J., Ewers, H., Schmitz, D. ORCID: https://orcid.org/0000-0003-2741-5241, Freund, C., Schmoranzer, J., Rademacher, N. and Shoichet, S.A. ORCID: https://orcid.org/0000-0003-4933-7846
PLoS Biology 20 (3): e3001503. 21 March 2022

Recruitment of release sites underlies chemical presynaptic potentiation at hippocampal mossy fiber boutons.
Orlando, M. ORCID: https://orcid.org/0000-0002-9017-0251, Dvorzhak, A. ORCID: https://orcid.org/0000-0002-1787-4850, Bruentgens, F. ORCID: https://orcid.org/0000-0001-7754-1313, Maglione, M., Rost, B.R., Sigrist, S.J., Breustedt, J. ORCID: https://orcid.org/0000-0003-4248-9919 and Schmitz, D. ORCID: https://orcid.org/0000-0003-2741-5241
PLoS Biology 19 (6): e3001149. 21 June 2021

NCX1 represents an ionic Na(+) sensing mechanism in macrophages.
Neubert, P., Homann, A., Wendelborn, D., Bär, A.L., Krampert, L. ORCID: https://orcid.org/0000-0002-8835-6145, Trum, M. ORCID: https://orcid.org/0000-0002-8267-2681, Schröder, A. ORCID: https://orcid.org/0000-0001-6010-9831, Ebner, S., Weichselbaum, A., Schatz, V. ORCID: https://orcid.org/0000-0001-7784-8753, Linz, P. ORCID: https://orcid.org/0000-0002-8232-1443, Veelken, R. ORCID: https://orcid.org/0000-0002-4254-6322, Schulte-Schrepping, J. ORCID: https://orcid.org/0000-0001-7333-8924, Aschenbrenner, A.C. ORCID: https://orcid.org/0000-0002-9429-5457, Quast, T., Kurts, C., Geisberger, S. ORCID: https://orcid.org/0000-0001-6477-1312, Kunzelmann, K. ORCID: https://orcid.org/0000-0001-6222-4593, Hammer, K. ORCID: https://orcid.org/0000-0003-2015-0682, Binger, K.J. ORCID: https://orcid.org/0000-0003-1139-3308, Titze, J. ORCID: https://orcid.org/0000-0001-8463-8404, Müller, D.N. ORCID: https://orcid.org/0000-0003-3650-5644, Kolanus, W. ORCID: https://orcid.org/0000-0003-1325-9444, Schultze, J.L. ORCID: https://orcid.org/0000-0003-2812-9853, Wagner, S. ORCID: https://orcid.org/0000-0002-9471-1166 and Jantsch, J. ORCID: https://orcid.org/0000-0001-6944-2913
PLoS Biology 18 (6): e3000722. 22 June 2020

Identification of N-linked glycans as specific mediators of neuronal uptake of acetylated α-Synuclein.
Birol, M. ORCID: https://orcid.org/0000-0003-3397-8446, Wojcik, S.P., Miranker, A.D. and Rhoades, E. ORCID: https://orcid.org/0000-0002-1741-0650
PLoS Biology 17 (6): e3000318. 18 June 2019

The Ink4a/Arf locus operates as a regulator of the circadian clock modulating RAS activity.
El-Athman, R., Genov, N.N., Mazuch, J., Zhang, K., Yu, Y. ORCID: https://orcid.org/0000-0003-1928-2514, Fuhr, L., Abreu, M., Li, Y., Wallach, T., Kramer, A., Schmitt, C.A. ORCID: https://orcid.org/0000-0002-4731-2226 and Relógio, A. ORCID: https://orcid.org/0000-0002-9165-2439
PLoS Biology 15 (12): e2002940. 7 December 2017

Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1.
Juneja, M., Kobelt, D. ORCID: https://orcid.org/0000-0002-9373-0648, Walther, W. ORCID: https://orcid.org/0000-0003-2884-0231, Voss, C., Smith, J., Specker, E. ORCID: https://orcid.org/0000-0002-9471-9520, Neuenschwander, M. ORCID: https://orcid.org/0000-0002-3114-7975, Gohlke, B.O. ORCID: https://orcid.org/0000-0003-3094-1031, Dahlmann, M. ORCID: https://orcid.org/0000-0002-0036-5283, Radetzki, S. ORCID: https://orcid.org/0000-0003-2688-2868, Preissner, R., von Kries, J.P. ORCID: https://orcid.org/0000-0003-4716-4988, Schlag, P.M. and Stein, U. ORCID: https://orcid.org/0000-0001-7006-282X
PLoS Biology 15 (6): e2000784. 1 June 2017

Ryanodine receptor activation induces long-term plasticity of spine calcium dynamics.
Johenning, F.W., Theis, A.K., Pannasch, U. ORCID: https://orcid.org/0000-0001-6502-1046, Rückl, M., Rüdiger, S. and Schmitz, D. ORCID: https://orcid.org/0000-0003-2741-5241
PLoS Biology 13 (6): e1002181. 22 June 2015

Dynamic endothelial cell rearrangements drive developmental vessel regression.
Franco, C.A., Jones, M.L., Bernabeu, M.O., Geudens, I., Mathivet, T., Rosa, A., Lopes, F.M., Lima, A.P., Ragab, A., Collins, R.T. ORCID: https://orcid.org/0000-0002-1847-4517, Phng, L.K., Coveney, P.V. and Gerhardt, H. ORCID: https://orcid.org/0000-0002-3030-0384
PLoS Biology 13 (4): e1002125. 17 April 2015

Composition, formation, and regulation of the cytosolic c-ring, a dynamic component of the type III secretion injectisome.
Diepold, A., Kudryashev, M. ORCID: https://orcid.org/0000-0003-3550-6274, Delalez, N.J., Berry, R.M. and Armitage, J.P.
PLoS Biology 13 (1): e1002039. 15 January 2015

In vitro generation of neuromesodermal progenitors reveals distinct roles for wnt signalling in the specification of spinal cord and paraxial mesoderm identity.
Gouti, M. ORCID: https://orcid.org/0000-0001-7422-1605, Tsakiridis, A., Wymeersch, F.J., Huang, Y., Kleinjung, J., Wilson, V. and Briscoe, J.
PLoS Biology 12 (8): e1001937. 26 August 2014

Palmitoylation of gephyrin controls receptor clustering and plasticity of GABAergic synapses.
Dejanovic, B., Semtner, M. ORCID: https://orcid.org/0000-0001-9379-9023, Ebert, S., Lamkemeyer, T., Neuser, F., Luescher, B., Meier, J.C. ORCID: https://orcid.org/0000-0001-5574-3336 and Schwarz, G.
PLoS Biology 12 (7): e1001908. 15 July 2014

HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.
Mielcarek, M., Landles, C., Weiss, A., Bradaia, A., Seredenina, T., Inuabasi, L., Osborne, G.F., Wadel, K., Touller, C., Butler, R., Robertson, J., Franklin, S.A., Smith, D.L., Park, L., Marks, P.A., Wanker, E.E. ORCID: https://orcid.org/0000-0001-8072-1630, Olson, E.N., Luthi-Carter, R., van der Putten, H., Beaumont, V. and Bates, G.P.
PLoS Biology 11 (11): e1001717. November 2013

A genetic basis for mechanosensory traits in humans.
Frenzel, H., Bohlender, J., Pinsker, K., Wohlleben, B., Tank, J., Lechner, S.G. ORCID: https://orcid.org/0000-0001-9402-9127, Schiska, D., Jaijo, T., Rueschendorf, F. ORCID: https://orcid.org/0000-0001-5640-810X, Saar, K., Jordan, J. ORCID: https://orcid.org/0000-0003-4518-0706, Millan, J.M., Gross, M. and Lewin, G.R. ORCID: https://orcid.org/0000-0002-2890-6352
PLoS Biology 10 (5): e1001318. 1 May 2012

Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity.
Luo, C., Gangadharan, V., Bali, K.K., Xie, R.G., Agarwal, N., Kurejova, M., Tappe-Theodor, A., Tegeder, I., Feil, S., Lewin, G. ORCID: https://orcid.org/0000-0002-2890-6352, Polgar, E., Todd, A.J., Schlossmann, J., Hofmann, F., Liu, D.L., Hu, S.J., Feil, R., Kuner, T. and Kuner, R.
PLoS Biology 10 (3): e1001283. 13 March 2012

MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates.
Somel, M., Liu, X., Tang, L., Yan, Z., Hu, H., Guo, S., Jiang, X., Zhang, X., Xu, G., Xie, G. ORCID: https://orcid.org/0000-0002-8286-2987, Li, N. ORCID: https://orcid.org/0000-0001-6163-1648, Hu, Y. ORCID: https://orcid.org/0000-0002-5210-5301, Chen, W. ORCID: https://orcid.org/0000-0003-3263-1627, Paeaebo, S. and Khaitovich, P.
PLoS Biology 9 (12): e1001214. December 2011

Structure of a classical MHC class I molecule that binds "non-classical" ligands.
Hee, C.S., Gao, S. ORCID: https://orcid.org/0000-0001-7427-6681, Loll, B., Miller, M.M., Uchanska-Ziegler, B., Daumke, O. ORCID: https://orcid.org/0000-0002-6190-1414 and Ziegler, A.
PLoS Biology 8 (12): e1000557. 7 December 2010

An integrated micro- and macroarchitectural analysis of the drosophila brain by computer-assisted serial section electron microscopy.
Cardona, A., Saalfeld, S., Preibisch, S. ORCID: https://orcid.org/0000-0002-0276-494X, Schmid, B., Cheng, A., Pulokas, J., Tomancak, P. and Hartenstein, V.
PLoS Biology 8 (10): e1000502. 5 October 2010

Ontologies in quantitative biology: a basis for comparison, integration, and discovery.
Jensen, L.J. ORCID: https://orcid.org/0000-0001-7885-715X and Bork, P. ORCID: https://orcid.org/0000-0002-2627-833X
PLoS Biology 8 (5): e1000374. 25 May 2010

Poised transcription factories prime silent uPA gene prior to activation.
Ferrai, C., Xie, S.Q., Luraghi, P., Munari, D., Ramirez, F., Branco, M.R., Pombo, A. ORCID: https://orcid.org/0000-0002-7493-6288 and Crippa, M.P.
PLoS Biology 8 (1): e1000270. 5 January 2010

Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation.
Paulmann, N., Grohmann, M., Voigt, J.P., Bert, B., Vowinckel, J., Bader, M. ORCID: https://orcid.org/0000-0003-4780-4164, Skelin, M., Jevsek, M., Fink, H., Rupnik, M. and Walther, D.J.
PLoS Biology 7 (10): e1000229. 27 October 2009

Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber).
Park, T.J., Lu, Y., Jüttner, R. ORCID: https://orcid.org/0000-0003-3565-0698, Smith, E.S.J. ORCID: https://orcid.org/0000-0002-2699-1979, Hu, J., Brand, A., Wetzel, C. ORCID: https://orcid.org/0000-0003-0587-8018, Milenkovic, N. ORCID: https://orcid.org/0000-0002-0014-1140, Erdmann, B., Heppenstall, P.A., Laurito, C.E., Wilson, S.P. and Lewin, G.R. ORCID: https://orcid.org/0000-0002-2890-6352
PLoS Biology 6 (1): e13. 29 January 2008

Variants in a novel epidermal collagen gene (COL29A1) are associated with atopic dermatitis.
Soederhaell, C., Marenholz, I. ORCID: https://orcid.org/0009-0007-6933-3849, Kerscher, T., Rueschendorf, F. ORCID: https://orcid.org/0000-0001-5640-810X, Esparza-Gordillo, J., Worm, M., Gruber, C., Mayr, G., Albrecht, M., Rohde, K., Schulz, H. ORCID: https://orcid.org/0000-0002-0226-964X, Wahn, U., Huebner, N. ORCID: https://orcid.org/0000-0002-1218-6223 and Lee, Y.A. ORCID: https://orcid.org/0000-0002-1817-9163
PLoS Biology 5 (9): e242. September 2007

Intermingling of chromosome territories in interphase suggests role in translocations and transcription-dependent associations.
Branco, M.R. and Pombo, A. ORCID: https://orcid.org/0000-0002-7493-6288
PLoS Biology 4 (5): e138. May 2006

Systematic association of genes to phenotypes by genome and literature mining.
Korbel, J.O., Doerks, T., Jensen, L.J. ORCID: https://orcid.org/0000-0001-7885-715X, Perez-Iratxeta, C., Kaczanowski, S., Hooper, S.D., Andrade, M.A. ORCID: https://orcid.org/0000-0001-6650-1711 and Bork, P. ORCID: https://orcid.org/0000-0002-2627-833X
PLoS Biology 3 (5): e134. 5 April 2005

Transcriptional control in the segmentation gene network of Drosophila.
Schroeder, M.D., Pearce, M., Fak, J., Fan, H., Unnerstall, U., Emberly, E., Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332, Siggia, E.D. and Gaul, U.
PLoS Biology 2 (9): E271. September 2004

Editorial

The IBEX Knowledge-Base: a central resource for multiplexed imaging techniques.
Radtke, A.J. ORCID: https://orcid.org/0000-0003-4379-8967, Anidi, I.U., Arakkal, L., Arroyo-Mejias, A.J., Beuschel, R.T., Börner, K., Chu, C.J., Clark, B., Clatworthy, M.R., Colautti, J., Coscia, F. ORCID: https://orcid.org/0000-0002-2244-5081, Croteau, J., Denha, S., Dever, R., Dutra, W.O., Fritzsche, S. ORCID: https://orcid.org/0000-0003-3335-3534, Fullam, S., Gerner, M.Y., Gola, A., Gollob, K.J., Hernandez, J.M., Hor, J.L., Ichise, H., Jing, Z., Jonigk, D., Kandov, E., Kastenmüller, W., Koenig, J.F.E., Kortekaas, R.K., Kothurkar, A., Kreins, A.Y., Lamborn, I.T., Lin, Y., Morais, K.L.P., Lunich, A., Luz, J.C.S., MacDonald, R.B., Makranz, C., Maltez, V.I., McDonough, J.E., Moriarty, R.V., Ocampo-Godinez, J.M., Olyntho, V.M., Oxenius, A., Padhan, K., Remmert, K., Richoz, N., Schrom, E.C., Shang, W., Shi, L., Shih, R.M., Speranza, E., Stierli, S., Teichmann, S.A., Veres, T.Z., Vierhout, M., Wachter, B.T., Wade-Vallance, A.K., Williams, M., Zangger, N., Germain, R.N. and Yaniv, Zi.
PLoS Biology 23 (3): e3003070. 19 March 2025