2025

Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus.
Matera, A., Compagnion, A.C., Pedicone, C., Janssen, M.K., Ivanov, A. ORCID: https://orcid.org/0000-0002-4824-1925, Monsorno, K., Labouèbe, G., Leggio, L., Pereira, M., Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Mansuy-Aubert, V., Williams, T.L., Iraci, N., Sierra, A., Marro, S.G., Goate, A.M., Eggen, B.L., Kerr, W.G. and Paolicelli, R.C.
Immunity 58 (1): 197-217. 14 January 2025

2024

Autoantigen-specific CD4(+) T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases.
Saggau, C., Bacher, P., Esser, D., Rasa, M., Meise, S., Mohr, N., Kohlstedt, N., Hutloff, A., Schacht, S.S., Dargvainiene, J., Martini, G.R., Stürner, K.H., Schröder, I., Markewitz, R., Hartl, J., Hastermann, M. ORCID: https://orcid.org/0000-0003-0769-0115, Duchow, A., Schindler, P., Becker, M., Bautista, C., Gottfreund, J., Walter, J., Polansky, J.K., Yang, M., Naghavian, R., Wendorff, M., Schuster, E.M., Dahl, A., Petzold, A., Reinhardt, S., Franke, A., Wieczorek, M., Henschel, L., Berger, D., Heine, G., Holtsche, M., Häußler, V., Peters, C., Schmidt, E., Fillatreau, S., Busch, D.H., Wandinger, K.P., Schober, K., Martin, R., Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070, Leypoldt, F. and Scheffold, A.
Immunity 57 (10): 2416-2432. 8 October 2024

Antibodies and complement are key drivers of thrombosis.
Stark, K., Kilani, B., Stockhausen, S., Busse, J., Schubert, I., Tran, T.D., Gaertner, F., Leunig, A., Pekayvaz, K., Nicolai, L., Fumagalli, V., Stermann, J., Stephan, F., David, C., Müller, M.B., Heyman, B., Lux, A., da Palma Guerreiro, A., Frenzel, L.P., Schmidt, C.Q., Dopler, A., Moser, M., Chandraratne, Sue, von Brühl, M.L., Lorenz, M., Korff, T., Rudelius, M., Popp, O. ORCID: https://orcid.org/0000-0001-6240-4666, Kirchner, M. ORCID: https://orcid.org/0000-0002-7049-534X, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Nimmerjahn, F., Iannacone, M., Sperandio, M., Engelmann, B., Verschoor, A. and Massberg, S.
Immunity 57 (9): 2140-2156.e10. 10 September 2024

2023

A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation.
Vallecillo-García, P., Orgeur, M., Comai, G., Poehle-Kronnawitter, S., Fischer, C. ORCID: https://orcid.org/0000-0003-0329-2435, Gloger, M., Dumas, C.E., Giesecke-Thiel, C., Sauer, S. ORCID: https://orcid.org/0000-0002-4794-3693, Tajbakhsh, S., Höpken, U.E. ORCID: https://orcid.org/0000-0002-0776-4893 and Stricker, S.
Immunity 56 (6): 1204-1219. 13 June 2023

2021

Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.
Krämer, B., Knoll, R. ORCID: https://orcid.org/0000-0001-8320-5885, Bonaguro, L., ToVinh, M. ORCID: https://orcid.org/0000-0002-1625-9741, Raabe, J. ORCID: https://orcid.org/0000-0002-6894-1451, Astaburuaga-García, R., Schulte-Schrepping, J., Kaiser, K.M., Rieke, G.J., Bischoff, J., Monin, M.B., Hoffmeister, C. ORCID: https://orcid.org/0000-0001-6473-4087, Schlabe, S., De Domenico, E., Reusch, N. ORCID: https://orcid.org/0000-0001-5625-0701, Händler, K., Reynolds, G., Blüthgen, N. ORCID: https://orcid.org/0000-0002-0171-7447, Hack, G., Finnemann, C., Nischalke, H.D., Strassburg, C.P., Stephenson, E., Su, Y., Gardner, L., Yuan, D., Chen, D., Goldman, J., Rosenstiel, P., Schmidt, S.V., Latz, E., Hrusovsky, K., Ball, A.J., Johnson, J.M., Koenig, P.A., Schmidt, F.I., Haniffa, M., Heath, J.R., Kümmerer, B.M., Keitel, V., Jensen, B., Stubbemann, P., Kurth, F., Sander, L.E., Sawitzki, B., Aschenbrenner, A.C., Schultze, J.L. and Nattermann, J.
Immunity 54 (11): 2650-2669. 9 November 2021

The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-mediated immune responses.
Jongsma, M.L.M., de Waard, A.A., Raaben, M., Zhang, T., Cabukusta, B., Platzer, R., Blomen, V.A., Xagara, A., Verkerk, T., Bliss, S., Kong, X., Gerke, C., Janssen, L., Stickel, E., Holst, S., Plomp, R., Mulder, A., Ferrone, S., Claas, F.H.J., Heemskerk, M.H.M, Griffioen, M., Halenius, A., Overkleeft, H., Huppa, J.B. ORCID: https://orcid.org/0000-0003-2634-8198, Wuhrer, M., Brummelkamp, T.R., Neefjes, J. and Spaapen, R.M.
Immunity 54 (1): 132-150.e9. 12 January 2021

2020

Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells, and plasmablasts as hallmarks of severe COVID-19.
Bernardes, J.P., Mishra, N., Tran, F., Bahmer, T., Best, L., Blase, J.I., Bordoni, D., Franzenburg, J., Geisen, U., Josephs-Spaulding, J., Köhler, P., Künstner, A., Rosati, E., Aschenbrenner, A.C., Bacher, P., Baran, N., Boysen, T., Brandt, B., Bruse, N., Dörr, J., Dräger, A., Elke, G., Ellinghaus, D., Fischer, J., Forster, M., Franke, A., Franzenburg, S., Frey, N., Friedrichs, A., Fuß, J., Glück, A., Hamm, J., Hinrichsen, F., Hoeppner, M.P., Imm, S., Junker, R., Kaiser, S., Kan, Y.H., Knoll, R., Lange, C., Laue, G., Lier, C., Lindner, M., Marinos, G., Markewitz, R., Nattermann, J., Noth, R., Pickkers, P., Rabe, K.F., Renz, A., Röcken, C., Rupp, J., Schaffarzyk, A., Scheffold, A., Schulte-Schrepping, J., Schunk, D., Skowasch, D., Ulas, T., Wandinger, K.P., Wittig, M., Zimmermann, J., Busch, H., Hoyer, B.F., Kaleta, C., Heyckendorf, J., Kox, M., Rybniker, J., Schreiber, S., Schultze, J.L. and Rosenstiel, P.
Immunity 53 (6): 1296-1314. 15 December 2020

Transfer of cGAMP into bystander cells via LRRC8 volume-regulated anion channels augments STING-mediated interferon responses and anti-viral immunity.
Zhou, C., Chen, X., Planells-Cases, R., Chu, J., Wang, L., Cao, L., Li, Z., López-Cayuqueo, K.I. ORCID: https://orcid.org/0000-0001-8409-7345, Xie, Y., Ye, S., Wang, X., Ullrich, F. ORCID: https://orcid.org/0000-0002-1153-2040, Ma, S., Fang, Y., Zhang, X., Qian, Z., Liang, X., Cai, S.Q., Jiang, Z., Zhou, D., Leng, Q., Xiao, T.S., Lan, K., Yang, Ji., Li, H., Peng, C., Qiu, Z., Jentsch, T.J. ORCID: https://orcid.org/0000-0002-3509-2553 and Xiao, H.
Immunity 52 (5): 767-781. 19 May 2020

2018

The nuclear receptor PPARγ controls progressive macrophage polarization as a ligand-insensitive epigenomic ratchet of transcriptional memory.
Daniel, B., Nagy, G., Czimmerer, Z., Horvath, A., Hammers, D.W., Cuaranta-Monroy, I., Poliska, S., Tzerpos, P., Kolostyak, Z., Hays, T.T., Patsalos, A., Houtman, R., Sauer, S. ORCID: https://orcid.org/0000-0002-4794-3693, Francois-Deleuze, J., Rastinejad, F., Balint, B.L., Sweeney, H.L. and Nagy, L.
Immunity 49 (4): 615-626. 16 October 2018

Developmental and functional heterogeneity of monocytes.
Guilliams, M., Mildner, A. ORCID: https://orcid.org/0000-0002-2019-8427 and Yona, S.
Immunity 49 (4): 595-613. 16 October 2018

The transcription factor STAT6 mediates direct repression of inflammatory enhancers and limits activation of alternatively polarized macrophages.
Czimmerer, Z., Daniel, B., Horvath, A., Rückerl, D., Nagy, G., Kiss, M., Peloquin, M., Budai, M.M., Cuaranta-Monroy, I., Simandi, Z., Steiner, L., Nagy, B., Poliska, S., Banko, C., Bacso, Z., Schulman, I.G., Sauer, S. ORCID: https://orcid.org/0000-0002-4794-3693, Deleuze, J.F., Allen, J.E., Benko, S. and Nagy, L.
Immunity 48 (1): 75-90. 16 January 2018

NKp46 receptor-mediated interferon-γ production by natural killer cells increases fibronectin 1 to alter tumor architecture and control metastasis.
Glasner, A., Levi, A., Enk, J., Isaacson, B., Viukov, S., Orlanski, S., Scope, A., Neuman, T., Enk, C.D., Hanna, J.H., Sexl, V., Jonjic, S., Seliger, B., Zitvogel, L. and Mandelboim, O.
Immunity 48 (1): 107-119. 16 January 2018

2017

Autophagy-dependent generation of free fatty acids is critical for normal neutrophil differentiation.
Riffelmacher, T., Clarke, A., Richter, F.C., Stranks, A., Pandey, S., Danielli, S., Hublitz, P., Yu, Z., Johnson, E., Schwerd, T., McCullagh, J., Uhlig, H., Jacobsen, S.E.W. and Simon, A.K. ORCID: https://orcid.org/0000-0002-4077-7995
Immunity 47 (3): 466-480.e5. 19 September 2017

Genomic characterization of murine monocytes reveals C/EBPβ transcription factor dependence of Ly6C(-) cells.
Mildner, A. ORCID: https://orcid.org/0000-0002-2019-8427, Schönheit, J., Giladi, A., David, E., Lara-Astiaso, D., Lorenzo-Vivas, E., Paul, F., Chappell-Maor, L., Priller, J. ORCID: https://orcid.org/0000-0001-7596-0979, Leutz, A. ORCID: https://orcid.org/0000-0001-8259-927X, Amit, I. and Jung, S.
Immunity 46 (5): 849-862. 16 May 2017

2016

Epigenomic profiling of human CD4(+) T cells supports a linear differentiation model and highlights molecular regulators of memory development.
Durek, P., Nordström, K., Gasparoni, G., Salhab, A., Kressler, C., de Almeida, M., Bassler, K., Ulas, T., Schmidt, F., Xiong, J. ORCID: https://orcid.org/0000-0002-4302-3515, Glažar, P. ORCID: https://orcid.org/0000-0003-0842-0088, Klironomos, F., Sinha, A., Kinkley, S., Yang, X., Arrigoni, L., Amirabad, A.., Ardakani, F.B., Feuerbach, L., Gorka, O., Ebert, P., Müller, F., Li, N., Frischbutter, S., Schlickeiser, S., Cendon, C., Fröhler, S. ORCID: https://orcid.org/0000-0001-8000-2927, Felder, B., Gasparoni, N., Imbusch, C.D., Hutter, B., Zipprich, G., Tauchmann, Y., Reinke, S., Wassilew, G., Hoffmann, U., Richter, A.S., Sieverling, L., Chang, H.D., Syrbe, U., Kalus, U., Eils, J., Brors, B., Manke, T., Ruland, J., Lengauer, T., Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332, Chen, W. ORCID: https://orcid.org/0000-0003-3263-1627, Dong, J., Sawitzki, B., Chung, H.R., Rosenstiel, P., Schulz, M.H., Schultze, J.L., Radbruch, A., Walter, J., Hamann, A. and Polansky, J.K.
Immunity 45 (5): 1148-1161. 15 November 2016

Thymus-derived regulatory T cells are positively selected on natural self-antigen through cognate interactions of high functional avidity.
Kieback, E. ORCID: https://orcid.org/0000-0003-3831-2846, Hilgenberg, E., Stervbo, U. ORCID: https://orcid.org/0000-0002-2831-8868, Lampropoulou, V., Shen, P., Bunse, M. ORCID: https://orcid.org/0000-0002-7554-2520, Jaimes, Y., Boudinot, P., Radbruch, A., Klemm, U., Kühl, A.A., Liblau, R., Hoevelmeyer, N., Anderton, S.M., Uckert, W. and Fillatreau, S.
Immunity 44 (5): 1114-1126. 17 May 2016

2015

PI3 kinase and FOXO1 transcription factor activity differentially control B cells in the germinal center light and dark zones.
Sander, S. ORCID: https://orcid.org/0000-0003-4645-3366, Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696, Yasuda, T. ORCID: https://orcid.org/0000-0001-9997-6852, Franklin, A., Graf, R. ORCID: https://orcid.org/0000-0002-5400-9938, Calado, D.P. ORCID: https://orcid.org/0000-0001-8239-7184, Li, S., Imami, K. ORCID: https://orcid.org/0000-0002-7451-4982, Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751, Di Virgilio, M. ORCID: https://orcid.org/0000-0001-5189-0793, Bullinger, L. ORCID: https://orcid.org/0000-0002-5890-5510 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Immunity 43 (6): 1075-1086. 15 December 2015

Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine.
Haghikia, A., Jörg, S., Duscha, A., Berg, J., Manzel, A., Waschbisch, A., Hammer, A., Lee, D.H., May, C., Wilck, N. ORCID: https://orcid.org/0000-0003-3189-5364, Balogh, A. ORCID: https://orcid.org/0000-0001-8756-747X, Ostermann, A.I., Schebb, N.H., Akkad, D.A., Grohme, D.A., Kleinewietfeld, M. ORCID: https://orcid.org/0000-0002-2832-3149, Kempa, S. ORCID: https://orcid.org/0000-0002-0696-9299, Thöne, J., Demir, S., Müller, D.N. ORCID: https://orcid.org/0000-0003-3650-5644, Gold, R. and Linker, R.A.
Immunity 43 (4): 817-829. 20 October 2015

Monocytes compensate Kupffer cell loss during bacterial infection.
Molawi, K. and Sieweke, M.H. ORCID: https://orcid.org/0000-0002-3228-9537
Immunity 42 (1): 10-12. 20 January 2015

2012

The sorting receptor sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.
Herda, S., Raczkowski, F., Mittruecker, H.W., Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X, Gerlach, K., Kuehl, A.A., Breiderhoff, T. ORCID: https://orcid.org/0000-0002-1676-7498, Willnow, T.E. ORCID: https://orcid.org/0000-0001-9515-7921, Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643, Höpken, U.E. ORCID: https://orcid.org/0000-0002-0776-4893 and Rehm, A. ORCID: https://orcid.org/0000-0001-7490-1950
Immunity 37 (5): 854-866. 16 November 2012

Galectin-1 deactivates classically activated microglia and protects from inflammation-induced neurodegeneration.
Starossom, S.C. ORCID: https://orcid.org/0000-0001-7935-9910, Mascanfroni, I.D., Imitola, J., Cao, L., Raddassi, K., Hernandez, S.F., Bassil, R., Croci, D.O., Cerliani, J.P., Delacour, D., Wang, Y., Elyaman, W., Khoury, S.J. and Rabinovich, G.A.
Immunity 37 (2): 249-63. 24 August 2012

Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium.
Roberts, N.A., White, A.J., Jenkinson, W.E., Turchinovich, G., Nakamura, K., Withers, D.R., McConnell, F.M., Desanti, G.E., Benezech, C., Parnell, S.M., Cunningham, A.F., Paolino, M., Penninger, J.M., Simon, A.K. ORCID: https://orcid.org/0000-0002-4077-7995, Nitta, T., Ohigashi, I., Takahama, Y., Caamano, J.H., Hayday, A.C., Lane, P.J.L., Jenkinson, E.J. and Anderson, G.
Immunity 36 (3): 427-37. 23 March 2012

2011

Structure of myxovirus resistance protein A reveals intra- and intermolecular domain interactions required for the antiviral function.
Gao, S. ORCID: https://orcid.org/0000-0001-7427-6681, von der Malsburg, A., Dick, A. ORCID: https://orcid.org/0000-0003-0580-1897, Faelber, K., Schroeder, G.F., Haller, O., Kochs, G. and Daumke, O. ORCID: https://orcid.org/0000-0002-6190-1414
Immunity 35 (4): 514-525. 28 October 2011

2010

In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis.
Siffrin, V. ORCID: https://orcid.org/0000-0002-1532-2868, Radbruch, H. ORCID: https://orcid.org/0000-0001-6941-3397, Glumm, R., Niesner, R. ORCID: https://orcid.org/0000-0001-8969-5432, Paterka, M., Herz, J., Leuenberger, T., Lehmann, S.M., Luenstedt, S., Rinnenthal, J.L., Laube, G., Luche, H., Lehnardt, S., Fehling, H.J., Griesbeck, O. and Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928
Immunity 33 (3): 424-436. 24 September 2010

Regulation of microRNA expression and abundance during lymphopoiesis.
Kuchen, S., Resch, W., Yamane, A., Kuo, N., Li, Z., Chakraborty, T., Wei, L., Laurence, A., Yasuda, T. ORCID: https://orcid.org/0000-0001-9997-6852, Peng, S., Hu-Li, J., Lu, K., Dubois, W., Kitamura, Y., Charles, N., Sun, H.W., Muljo, S., Schwartzberg, P.L., Paul, W.E., O'Shea, J., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Casellas, R.
Immunity 32 (6): 828-839. 25 June 2010

Quantitative proteomics reveals subset-specific viral recognition in dendritic cells.
Luber, C.A., Cox, J., Lauterbach, H., Fancke, B., Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751, Tschopp, J., Akira, S., Wiegand, M., Hochrein, H., O'Keeffe, M. and Mann, M.
Immunity 32 (2): 279-289. 26 February 2010

2008

MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation.
Dorsett, Y., McBride, K.M., Jankovic, M., Gazumyan, A., Thai, T.H., Robbiani, D.F., Di Virgilio, M. ORCID: https://orcid.org/0000-0001-5189-0793, Reina San-Martin, B., Heidkamp, G., Schwickert, T.A., Eisenreich, T., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Nussenzweig, M.C.
Immunity 28 (5): 630-638. 16 May 2008

2006

CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance.
Kurobe, H., Liu, C., Ueno, T., Saito, F., Ohigashi, I., Seach, N., Arakaki, R., Hayashi, Y., Kitagawa, T., Lipp, M. ORCID: https://orcid.org/0000-0002-0087-2672, Boyd, R.L. and Takahama, Y.
Immunity 24 (2): 165-177. February 2006

2005

Stroma-mediated dysregulation of myelopoiesis in mice lacking IkappaBalpha.
Rupec, R.A., Jundt, F., Rebholz, B., Eckelt, B., Weindl, G.N., Herzinger, T., Flaig, M.J., Moosmann, S., Plewig, G., Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643, Foerster, I., Huss, R. and Pfeffer, K.
Immunity 22 : 479-491. 1 January 2005

2004

CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions.
Ohl, L., Mohaupt, M., Czeloth, N., Hintzen, G., Kiafard, Z., Zwirner, J., Blankenstein, T., Henning, G. and Foerster, R.
Immunity 21 (2): 279-288. 1 August 2004

All roads lead to rome: triggering dendritic cell migration.
Höpken, U.E. ORCID: https://orcid.org/0000-0002-0776-4893 and Lipp, M. ORCID: https://orcid.org/0000-0002-0087-2672
Immunity 20 (3): 244-246. March 2004

2002

CD4+CD3- cells induce Peyer's patch development: role of α4 β1 integrin activation by CXCR5.
Finke, D., Acha-Orbea, H., Mattis, A., Lipp, M. ORCID: https://orcid.org/0000-0002-0087-2672 and Kraehenbuhl, J.P.
Immunity 17 (3): 363-373. September 2002

Role for CCR7 Ligands in the emigration of newly generated T lymphocytes from the neonatal thymus.
Ueno, T., Hara, K., Willis, M.S., Malin, M.A., Höpken, U.E. ORCID: https://orcid.org/0000-0002-0776-4893, Gray, D.H.D., Matsushima, K., Lipp, M., Springer, T.A., Boyd, R.L., Yoshie, O. and Takahama, Y.
Immunity 16 (2): 205-218. 1 January 2002

2000

CD4+ T cell-mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFNgamma receptor expression by nonhematopoietic cells.
Qin, Z.H. and Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321
Immunity 12 (6): 677-686. 1 June 2000

CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue.
Cook, D.N., Prosser, D.M., Forster, R., Zhang, J., Kuklin, N.A., Abbondanzo, S.J., Niu, X.D., Chen, S.C., Manfra, D.J., Wiekowski, M.T., Sullivan, L.M., Smith, S.R., Greenberg, H.B., Narula, S.K., Lipp, M. and Lira, S.A.
Immunity 12 (5): 495-503. 1 May 2000

1997

The alpha chain of the T cell antigen receptor is degraded in the cytosol.
Huppa, J.B. ORCID: https://orcid.org/0000-0003-2634-8198 and Ploegh, H.L.
Immunity 7 (1): 113-22. 1 July 1997

1995

Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand.
Windhagen, A., Scholz, C., Hoellsberg, P., Fukaura, H., Sette, A. and Hafler, D.A.
Immunity 2 : 373-380. 1 January 1995