Browse by Research Team

2024

Microglial sex differences in innate high anxiety and modulatory effects of minocycline.
Ugursu, B. and Sah, A. and Sartori, S. and Popp, O. and Mertins, P. and Dunay, I.R. and Kettenmann, H. and Singewald, N. and Wolf, S.A.
Brain, Behavior and Immunity 27 March 2024 (In Press)

2023

Sex-specific microglia state in the neuroligin-4 knock-out mouse model of autism spectrum disorder.
Guneykaya, D. and Ugursu, B. and Logiacco, F. and Popp, O. and Feiks, M.A. and Meyer, N. and Wendt, S. and Semtner, M. and Cherif, F. and Gauthier, C. and Madore, C. and Yin, Z. and Çınar, Ö. and Arslan, T. and Gerevich, Z. and Mertins, P. and Butovsky, O. and Kettenmann, H. and Wolf, S.A.
Brain Behavior and Immunity 111 : 61-75. July 2023

Cesium activates the neurotransmitter receptor for glycine.
Fricke, S. and Harnau, M. and Hetsch, F. and Liu, H. and Leonhard, J. and Eylmann, A. and Knauff, P. and Sun, H. and Semtner, M. and Meier, J.C.
Frontiers in Molecular Neuroscience 16 : 1018530. 22 May 2023

Small molecule specifically inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation.
Jordan, P. and Costa, A. and Specker, E. and Popp, O. and Volkamer, A. and Piske, R. and Obrusnik, T. and Kleissle, S. and Stuke, K. and Rex, A. and Neuenschwander, M. and von Kries, J.P. and Nazare, M. and Mertins, P. and Kettenmann, H. and Wolf, S.A.
PLoS ONE 18 (2): e0278325. 6 February 2023

2022

Enriched environment attenuates enhanced trait anxiety in association with normalization of aberrant neuro-inflammatory events.
Sah, A. and Rooney, S. and Kharitonova, M. and Sartori, S.B. and Wolf, S.A. and Singewald, N.
International Journal of Molecular Sciences 23 (21): 13052. 27 October 2022

2021

Reduction of cortical parvalbumin expressing GABAergic interneurons in a rodent hyperoxia model of preterm birth brain injury with deficits in social behavior and cognition.
Scheuer, T. and Auf dem Brinke, E. and Grosser, S. and Wolf, S.A. and Mattei, D. and Sharkovska, Y. and Barthel, P.C. and Endesfelder, S. and Friedrich, V. and Bührer, C. and Vida, I. and Schmitz, T.
Development 148 (20): dev.198390. October 2021

Potential effects of nutraceuticals in retinopathy of prematurity.
Tsang, J.K.W. and Wolf, S.A. and Pompoes, I.M. and Joussen, A.M. and Lam, W.C. and Yang, D. and Lo, A.C.Y.
Life 11 (2): 79. 22 January 2021

Deletion of muscarinic acetylcholine receptor 3 in microglia impacts brain ischemic injury.
Costa, A. and Haage, V. and Yang, S. and Wegner, S. and Ersoy, B. and Ugursu, B. and Rex, A. and Kronenberg, G. and Gertz, K. and Endres, M. and Wolf, S.A. and Kettenmann, H.
Brain Behavior and Immunity 91 : 89-104. January 2021

2020

Neuroinflammatory alterations in trait anxiety: modulatory effects of minocycline.
Rooney, S. and Sah, A. and Unger, M.S. and Kharitonova, M. and Sartori, S.B. and Schwarzer, C. and Aigner, L. and Kettenmann, H. and Wolf, S.A. and Singewald, N.
Translational Psychiatry 10 (1): 256. 30 July 2020

The VGF-derived peptide TLQP21 impairs purinergic control of chemotaxis and phagocytosis in mouse microglia.
Elmadany, N. and de Almeida Sassi, F. and Wendt, S. and Logiacco, F. and Visser, J. and Haage, V. and Perez Hernandez, D. and Mertins, P. and Hambardzumyan, D. and Wolf, S. and Kettenmann, H. and Semtner, M.
Journal of Neuroscience 40 (17): 3320-3331. 22 April 2020

2019

let-7 microRNAs regulate microglial function and suppress glioma growth through Toll-like receptor 7.
Buonfiglioli, A. and Efe, I.E. and Guneykaya, D. and Ivanov, A. and Huang, Y. and Orlowski, E. and Krüger, C. and Deisz, R.A. and Markovic, D. and Flüh, C. and Newman, A.G. and Schneider, U.C. and Beule, D. and Wolf, S.A. and Dzaye, O. and Gutmann, D.H. and Semtner, M. and Kettenmann, H. and Lehnardt, S.
Cell Reports 29 (11): 3460-3471. 10 December 2019

2018

Transcriptional and translational differences of microglia from male and female brains.
Guneykaya, D. and Ivanov, A. and Perez Hernandez, D. and Haage, V. and Wojtas, B. and Meyer, N. and Maricos, M. and Jordan, P. and Buonfiglioli, A. and Gielniewski, B. and Ochocka, N. and Cömert, C. and Friedrich, C. and Suarez Artiles, L. and Kaminska, B. and Mertins, P. and Beule, D. and Kettenmann, H. and Wolf, S.A.
Cell Reports 24 (10): 2773-2783. 4 September 2018

Distinguishing features of microglia- and monocyte-derived macrophages after stroke.
Kronenberg, G. and Uhlemann, R. and Richter, N. and Klempin, F. and Wegner, S. and Staerck, L. and Wolf, S. and Uckert, W. and Kettenmann, H. and Endres, M. and Gertz, K.
Acta Neuropathologica 135 (4): 551. April 2018

Dataset on the activation of Mueller cells through macrophages upon hypoxia in the retina.
Nuernberg, C. and Kociok, N. and Brockmann, C. and Lischke, T. and Crespo-Garcia, S. and Reichhart, N. and Wolf, S. and Baumgrass, R. and Eming, S.A. and Beer-Hammer, S. and Joussen, A.M.
Data in Brief 16 : 489-500. February 2018

Myeloid cells contribute indirectly to VEGF expression upon hypoxia via activation of Müller cells.
Nuernberg, C. and Kociok, N. and Brockmann, C. and Lischke, T. and Crespo-Garcia, S. and Reichhart, N. and Wolf, S. and Baumgrass, R. and Eming, S.A. and Beer-Hammer, S. and Joussen, A.M.
Experimental Eye Research 166 : 56-69. January 2018

2017

You need guts to make new neurons.
Wolf, S.A. and Mattei, D.
Current Behavioral Neuroscience Reports 4 (4): 353-360. December 2017

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.
Piwecka, M. and Glažar, P. and Hernandez-Miranda, L.R. and Memczak, S. and Wolf, S.A. and Rybak-Wolf, A. and Filipchyk, A. and Klironomos, F. and Cerda Jara, C.A. and Fenske, P. and Trimbuch, T. and Zywitza, V. and Plass, M. and Schreyer, L. and Ayoub, S. and Kocks, C. and Kühn, R. and Rosenmund, C. and Birchmeier, C. and Rajewsky, N.
Science 357 (6357): eaam8526. 22 September 2017

Deep brain stimulation during early adolescence prevents microglial alterations in a model of maternal immune activation.
Hadar, R. and Dong, L. and Del-Valle-Anton, L. and Gueneykaya, D. and Voget, M. and Edemann-Callesen, H. and Schweibold, R. and Djodari-Irani, A. and Goetz, T. and Ewing, S. and Kettenmann, H. and Wolf, S.A. and Winter, C.
Brain, Behavior and Immunity 63 : 71-80. 7 July 2017

Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment.
Mattei, D. and Ivanov, A. and Ferrai, C. and Jordan, P. and Guneykaya, D. and Buonfiglioli, A. and Schaafsma, W. and Przanowski, P. and Deuther-Conrad, W. and Brust, P. and Hesse, S. and Patt, M. and Sabri, O. and Ross, T.L. and Eggen, B.J.L. and Boddeke, E.W.G.M. and Kaminska, B. and Beule, D. and Pombo, A. and Kettenmann, H. and Wolf, S.A.
Translational Psychiatry 7 (5): e1120. 9 May 2017

Cellular and molecular identity of tumor-associated macrophages in glioblastoma.
Chen, Z. and Feng, X. and Herting, C.J. and Alvarez Garcia, V. and Nie, K. and Pong, W.W. and Rasmussen, R. and Dwivedi, B. and Seby, S. and Wolf, S.A. and Gutmann, D.H. and Hambardzumyan, D.
Cancer Research 77 (9): 2266-2278. 1 May 2017

Rapid adaptation to microgravity in mammalian macrophage cells.
Thiel, C.S. and de Zélicourt, D. and Tauber, S. and Adrian, A. and Franz, M. and Simmet, D.M. and Schoppmann, K. and Hauschild, S. and Krammer, S. and Christen, M. and Bradacs, G. and Paulsen, K. and Wolf, S.A. and Braun, M. and Hatton, J. and Kurtcuoglu, V. and Franke, S. and Tanner, S. and Cristoforetti, S. and Sick, B. and Hock, B. and Ullrich, O.
Scientific Reports 7 (1): 43. 27 February 2017

Microglia in physiology and disease.
Wolf, S.A. and Boddeke, H.W.G.M. and Kettenmann, H.
Annual Review of Physiology 79 : 619-643. February 2017

2016

Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream.
Langenfurth, A. and Gu, S. and Bautze, V. and Zhang, C. and Neumann, J.E. and Schüller, U. and Stock, K. and Wolf, S.A. and Maier, A.M. and Mastrella, G. and Pak, A. and Cheng, H. and Kälin, R.E. and Holmbeck, K. and Strotmann, J. and Kettenmann, H. and Glass, R.
Scientific Reports 6 : 32203. 30 August 2016

2015

Long-lasting pro-inflammatory suppression of microglia by LPS-preconditioning is mediated by RelB-dependent epigenetic silencing.
Schaafsma, W. and Zhang, X. and van Zomeren, K.C. and Jacobs, S. and Georgieva, P.B. and Wolf, S.A. and Kettenmann, H. and Janova, H. and Saiepour, N. and Hanisch, U.K. and Meerlo, P. and van den Elsen, P.J. and Brouwer, N. and Boddeke, H.W.G.M. and Eggen, B.J.L.
Brain Behavior and Immunity 48 : 205-221. August 2015

Brain in flames - animal models of psychosis: utility and limitations.
Mattei, D. and Schweibold, R. and Wolf, S.A.
Neuropsychiatric Disease and Treatment 11 : 1313-1329. 27 May 2015

Vascular signal transducer and activator of transcription-3 promotes angiogenesis and neuroplasticity long-term after stroke.
Hoffmann, C.J. and Harms, U. and Rex, A. and Szulzewsky, F. and Wolf, S.A. and Grittner, U. and Lättig-Tünnemann, G. and Sendtner, M. and Kettenmann, H. and Dirnagl, U. and Endres, M. and Harms, C.
Circulation 131 (20): 1772-1782. 19 May 2015

Ly6C(high) monocytes control cerebral toxoplasmosis.
Biswas, A. and Bruder, D. and Wolf, S.A. and Jeron, A. and Mack, M. and Heimesaat, M.M. and Dunay, I.R.
Journal of Immunology 194 (7): 3223-3235. 1 April 2015

Intrathecal heat shock protein 60 mediates neurodegeneration and demyelination in the CNS through a TLR4-and MyD88-dependent pathway.
Rosenberger, K. and Dembny, P. and Derkow, K. and Engel, O. and Krüger, C. and Wolf, S.A. and Kettenmann, H. and Schott, E. and Meisel, A. and Lehnardt, S.
Molecular Neurodegeneration 10 : 5. 26 February 2015

Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1.
Szulzewsky, F. and Pelz, A. and Feng, X. and Synowitz, M. and Markovic, D. and Langmann, T. and Holtman, I.R. and Wang, X. and Eggen, B.J.L. and Boddeke, H.W.G.M. and Hambardzumyan, D. and Wolf, S.A. and Kettenmann, H.
PLoS ONE 10 (2): e0116644. 6 February 2015

Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages Toll-like receptor 2 signaling.
Hu, F. and a Dzaye, O.D. and Hahn, A. and Yu, Y. and Scavetta, R.J. and Dittmar, G. and Kaczmarek, A.K. and Dunning, K.R. and Ricciardelli, C. and Rinnenthal, J.L. and Heppner, F.L. and Lehnardt, S. and Synowitz, M. and Wolf, S.A. and Kettenmann, H.
Neuro-Oncology 17 (2): 200-210. February 2015

2014

Glioma-associated microglial MMP9 expression is upregulated by TLR2 signaling and sensitive to minocycline.
Hu, F. and Ku, M.C. and Markovic, D. and a Dzaye, O.D. and Lehnardt, S. and Synowitz, M. and Wolf, S.A. and Kettenmann, H.
International Journal of Cancer 135 (11): 2569-2578. December 2014

The capsaicin receptor TRPV1 as a novel modulator of neural precursor cell proliferation.
Stock, K. and Garthe, A. and de Almeida Sassi, F. and Glass, R. and Wolf, S.A. and Kettenmann, H.
Stem Cells 32 (12): 3183-3195. December 2014

Minocycline rescues decrease in neurogenesis, increase in microglia cytokines and deficits in sensorimotor gating in an animal model of schizophrenia.
Mattei, D. and Djodari-Irani, A. and Hadar, R. and Pelz, A. and de Cossio, L.F. and Goetz, T. and Matyash, M. and Kettenmann, H. and Winter, C. and Wolf, S.A.
Brain Behavior and Immunity 38 : 175-184. May 2014

The subpopulation of microglia sensitive to neurotransmitters/neurohormones is modulated by stimulation with LPS, interferon-γ, and IL-4.
Pannell, M. and Szulzewsky, F. and Matyash, V. and Wolf, S.A. and Kettenmann, H.
Glia 62 (5): 667-679. May 2014

Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases.
Langenfurth, A. and Rinnenthal, J.L. and Vinnakota, K. and Prinz, V. and Carlo, A.S. and Stadelmann, C. and Siffrin, V. and Peaschke, S. and Endres, M. and Heppner, F. and Glass, R. and Wolf, S.A. and Kettenmann, H.
Journal of Neuroscience Research 92 (3): 275-286. March 2014

2013

Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion.
Vinnakota, K. and Hu, F. and Ku, M.C. and Georgieva, P.B. and Szulzewsky, F. and Pohlmann, A. and Waiczies, S. and Waiczies, H. and Niendorf, T. and Lehnardt, S. and Hanisch, U.K. and Synowitz, M. and Markovic, D.S. and Wolf, S.A. and Glass, R. and Kettenmann, H.
Neuro-Oncology 15 (11): 1457-1468. November 2013

GDNF mediates glioblastoma-induced microglia attraction but not astrogliosis.
Ku, M.C. and Wolf, S.A. and Respondek, D. and Matyash, V. and Pohlmann, A. and Waiczies, S. and Waiczies, H. and Niendorf, T. and Synowitz, M. and Glass, R. and Kettenmann, H.
Acta Neuropathologica 125 (4): 609-620. April 2013

2010

Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis.
Wolf, S.A. and Bick-Sander, A. and Fabel, K. and Leal-Galicia, P. and Tauber, S. and Ramirez-Rodriguez, G. and Mueller, A. and Melnik, A. and Waltinger, T.P. and Ullrich, O. and Kempermann, G.
Cell Communication and Signaling 8 : 12. 17 June 2010

2009

Additive effects of physical exercise and environmental enrichment on adult hippocampal neurogenesis in mice.
Fabel, K. and Wolf, S.A. and Ehninger, D. and Babu, H. and Leal-Galicia, P. and Kempermann, G.
Frontiers in Neuroscience 3 : 50. 10 November 2009

Adaptive peripheral immune response increases proliferation of neural precursor cells in the adult hippocampus.
Wolf, S.A. and Steiner, B. and Wengner, A.M. and Lipp, M. and Kammertoens, T. and Kempermann, G.
FASEB Journal 23 (9): 3121-3128. September 2009

CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis.
Wolf, S.A. and Steiner, B. and Akpinarli, A. and Kammertoens, T. and Nassenstein, C. and Braun, A. and Blankenstein, T. and Kempermann, G.
Journal of Immunology 182 (7): 3979-3984. 1 April 2009

2008

Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis.
Rohe, M. and Carlo, A.S. and Breyhan, H. and Sporbert, A. and Militz, D. and Schmidt, V. and Wozny, C. and Harmeier, A. and Erdmann, B. and Bales, K.R. and Wolf, S.A. and Kempermann, G. and Paul, S.M. and Schmitz, D. and Bayer, T.A. and Willnow, T.E. and Andersen, O.M.
Journal of Biological Chemistry 283 (21): 14826-14834. 23 May 2008

Intermediate progenitors in adult hippocampal neurogenesis: Tbr2 expression and coordinate regulation of neuronal output.
Hodge, R.D. and Kowalczyk, T.D. and Wolf, S.A. and Encinas, J.M. and Rippey, C. and Enikolopov, G. and Kempermann, G. and Hevner, R.F.
Journal of Neuroscience 28 (14): 3707-3717. 2 April 2008

2006

Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer's disease.
Wolf, S.A. and Kronenberg, G. and Lehmann, K. and Blankenship, A. and Overall, R. and Staufenbiel, M. and Kempermann, G.
Biological Psychiatry 60 (12): 1314-1323. 15 December 2006

Running in pregnancy transiently increases postnatal hippocampal neurogenesis in the offspring.
Bick-Sander, A. and Steiner, B. and Wolf, S.A. and Babu, H. and Kempermann, G.
Proceedings of the National Academy of Sciences of the United States of America 103 (10): 3852-3857. 7 March 2006

The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells.
Eljaschewitsch, E. and Witting, A. and Mawrin, C. and Lee, T. and Schmidt, P.M. and Wolf, S. and Hoertnagl, H. and Raine, C.S. and Schneider-Stock, R. and Nitsch, R. and Ullrich, O.
Neuron 49 (1): 67-79. 5 January 2006

Adult neurogenesis and neurodegenerative disease.
Steiner, B. and Wolf, S.A. and Kempermann, G.
Regenerative Medicine 1 (1): 15-28. January 2006