Browse by Research Team

2024

Atypical KCNQ1/Kv7 channel function in a neonatal diabetes patient: hypersecretion preceded the failure of pancreatic β-cells.
Zhou, Z., Gong, M., Pande, A., Margineanu, A., Lisewski, U., Purfürst, B., Zhu, H., Liang, L., Jia, S., Froehler, S., Zeng, C., Kühnen, P., Khodaverdi, S., Krill, W., Röpke, T., Chen, W., Raile, K., Sander, M. and Izsvák, Z.
iScience 27 (7): 110291. 19 July 2024

IFT88 maintains sensory function by localising signalling proteins along Drosophila cilia.
Werner, S., Okenve-Ramos, P., Hehlert, P., Zitouni, S., Priya, P., Mendonça, S., Sporbert, A., Spalthoff, C., Göpfert, M.C., Jana, S.C. and Bettencourt-Dias, M.
Life Science Alliance 7 (5): e202302289. May 2024

Mice with renal-specific alterations 1 of stem cell-associated signaling develop symptoms of chronic kidney disease but surprisingly no tumors.
Myszczyszyn, A., Popp, O., Kunz, S., Sporbert, A., Jung, S., Penning, L.C., Fendler, A., Mertins, P. and Birchmeier, W.
PLoS ONE 19 (3): e0282938. 21 March 2024

2023

In vitro production of naked mole-rats' blastocysts from non-breeding females using in vitro maturation and intracytoplasmic sperm injection.
Simone, R., Čižmár, D., Holtze, S., Michel, G., Sporbert, A., Okolo, C. and Hildebrandt, T.B.
Scientific Reports 13 (1): 22355. 15 December 2023

A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease.
Boeddrich, A., Haenig, C., Neuendorf, N., Blanc, E., Ivanov, A., Kirchner, M., Schleumann, P., Bayraktaroğlu, I., Richter, M., Molenda, C.M., Sporbert, A., Zenkner, M., Schnoegl, S., Suenkel, C., Schneider, L.S., Rybak-Wolf, A., Kochnowsky, B., Byrne, L.M., Wild, E.J., Nielsen, J.E., Dittmar, G., Peters, O., Beule, D. and Wanker, E.E.
Genome Medicine 15 (1): 50. 20 July 2023

LRP2 contributes to planar cell polarity-dependent coordination of motile cilia function.
Bunatyan, L., Margineanu, A., Boutin, C., Montcouquiol, M., Bachmann, S., Christensen, E.I., Willnow, T.E. and Christ, A.
Cell and Tissue Research 392 (2): 535-551. May 2023

Balancing WNT signalling in early forebrain development: The role of LRP4 as a modulator of LRP6 function.
Geng, S., Paul, F., Kowalczyk, I., Raimundo, S., Sporbert, A., Mamo, T.M. and Hammes, A.
Frontiers in Cell and Developmental Biology 11 : 1173688. 7 April 2023

IFNγ binding to extracellular matrix prevents fatal systemic toxicity.
Kemna, J., Gout, E., Daniau, L., Lao, J., Weißert, K., Ammann, S., Kühn, R., Richter, M., Molenda, C., Sporbert, A., Zocholl, D., Klopfleisch, R., Schütz, A., Lortat-Jacob, H., Aichele, P., Kammertoens, T. and Blankenstein, T.
Nature Immunology 24 (3): 414-422. March 2023

2022

15-keto-Prostaglandin E(2) exhibits bioactive role by modulating glomerular cytoarchitecture through EP2/EP4 receptors.
Kourpa, A., Kaiser-Graf, D., Sporbert, A., Philippe, A., Catar, R., Rothe, M., Mangelsen, E., Schulz, A., Bolbrinker, J., Kreutz, R. and Panáková, D.
Life Sciences 310 : 121114. 1 December 2022

TSG101 associates with PARP1 and is essential for PARylation and DNA damage-induced NF-κB activation.
Tufan, A.B., Lazarow, K., Kolesnichenko, M., Sporbert, A., von Kries, J.P. and Scheidereit, C.
EMBO Journal 41 (21): e110372. 2 November 2022

A conserved long-distance telomeric silencing mechanism suppresses mTOR signaling in aging human fibroblasts.
Jäger, K., Mensch, J., Grimmig, M.E., Neuner, B., Gorzelniak, K., Türkmen, S., Demuth, I., Hartmann, A., Hartmann, C., Wittig, F., Sporbert, A., Hermann, A., Fuellen, G., Möller, S. and Walter, M.
Science Advances 8 (33): eabk2814. August 2022

Proteome-wide quantitative RNA-interactome capture identifies phosphorylation sites with regulatory potential in RBM20.
Vieira e Vieira, C.H., Dauksaite, V., Sporbert, A., Gotthardt, M. and Selbach, M.
Molecular Cell 82 (11): 2069-2083. 2 June 2022

2021

Microglia sense neuronal activity via GABA in the early postnatal hippocampus.
Logiacco, F., Xia, P., Georgiev, S.V., Franconi, C., Chang, Y.J., Ugursu, B., Sporbert, A., Kühn, R., Kettenmann, H. and Semtner, M.
Cell Reports 37 (13): 110128. 28 December 2021

An expanded polyproline domain maintains mutant huntingtin soluble in vivo and during aging.
Pigazzini, M.L., Lawrenz, M., Margineanu, A., Kaminski Schierle, G.S. and Kirstein, J.
Frontiers in Molecular Neuroscience 14 : 721749. 15 October 2021

Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche.
Willnow, D., Benary, U., Margineanu, A., Vignola, M.L., Konrath, F., Pongrac, I.M., Karimaddini, Z., Vigilante, A., Wolf, J. and Spagnoli, F.M.
Nature 597 (7874): 87-91. 2 September 2021

Identification of disease-relevant modulators of the SHH pathway in the developing brain.
Mecklenburg, N., Kowalczyk, I., Witte, F., Görne, J., Laier, A., Mamo, T.M., Gonschior, H., Lehmann, M., Richter, M., Sporbert, A., Purfürst, B., Hübner, N. and Hammes, A.
Development 148 (17): dev199307. September 2021

High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53.
Heuberger, J., Grinat, J., Kosel, F., Liu, L., Kunz, S., Vidal, R.O., Keil, M., Haybaeck, J., Robine, S., Louvard, D., Regenbrecht, C., Sporbert, A., Sauer, S., von Eyss, B., Sigal, M. and Birchmeier, W.
Proceedings of the National Academy of Sciences of the United States of America 118 (22): e2019699118. 1 June 2021

MACC1 regulates clathrin-mediated endocytosis and receptor recycling of transferrin receptor and EGFR in colorectal cancer.
Imbastari, F., Dahlmann, M., Sporbert, A., Ciolli Mattioli, C., Mari, T., Scholz, F., Timm, L., Twamley, S., Migotti, R., Walther, W., Dittmar, G., Rehm, A. and Stein, U.
Cellular and Molecular Life Sciences 78 (7): 3525-3542. April 2021

Photocaged Hoechst enables subnuclear visualization and cell selective staining of DNA in vivo.
Lämmle, C.A., Varady, A., Müller, T.G., Sturtzel, C., Riepl, M., Mathes, B., Eichhorst, J., Sporbert, A., Lehmann, M., Kräusslich, H.G., Distel, M. and Broichhagen, J.
ChemBioChem 22 (3): 548-556. 2 February 2021

2020

IFT88 transports Gucy2d, a guanylyl cyclase, to maintain sensory cilia function in Drosophila.
Werner, S., Zitouni, S., Okenve-Ramos, P., Mendonça, S., Sporbert, A., Spalthoff, C., Göpfert, M.C., Jana, S.C. and Bettencourt-Dias, M.
bioRxiv : 2020.12.15.417840. 15 December 2020

Collagen organization within the cartilage of TRPV4(-/-) mice studied with two-photon microscopy and polarized second harmonic generation.
Servin-Vences, M.R., Poole, K., Sporbert, A., Lewin, G.R. and Margineanu, A.
Cytometry Part A 97 (5): 504-514. May 2020

2019

Tight junction proteins at the blood-brain barrier: far more than claudin-5.
Berndt, P., Winkler, L., Cording, J., Breitkreuz-Korff, O., Rex, A., Dithmer, S., Rausch, V., Blasig, R., Richter, M., Sporbert, A., Wolburg, H., Blasig, I.E. and Haseloff, R.F.
Cellular and Molecular Life Sciences 76 (10): 1987-2002. May 2019

Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage.
Schulz, A., Müller, N.V., van de Lest, N.A., Eisenreich, A., Schmidbauer, M., Barysenka, A., Purfürst, B., Sporbert, A., Lorenzen, T., Meyer, A.M., Herlan, L., Witten, A., Rühle, F., Zhou, W., de Heer, E., Scharpfenecker, M., Panáková, D., Stoll, M. and Kreutz, R.
eLife 8 : e42068. 22 March 2019

2017

A new fate mapping system reveals context-dependent random or clonal expansion of microglia.
Tay, T.L., Mai, D., Dautzenberg, J., Fernández-Klett, F., Lin, G., Sagar, D.M., Datta, M., Drougard, A., Stempfl, T., Ardura-Fabregat, A., Staszewski, O., Margineanu, A., Sporbert, A., Steinmetz, L.M., Pospisilik, J.A., Jung, S., Priller, J., Grün, D., Ronneberger, O. and Prinz, M.
Nature Neuroscience 20 (6): 793-803. June 2017

2016

Nuclear translocation of the cardiac L-type calcium channel C-terminus is regulated by sex and 17β-estradiol.
Mahmoodzadeh, S., Haase, H., Sporbert, A., Rharass, T., Panáková, D. and Morano, I.
Journal of Molecular and Cellular Cardiology 97 : 226-234. August 2016

Advanced light microscopy core facilities: Balancing service, science and career.
Ferrando-May, E., Hartmann, H., Reymann, J., Ansari, N., Utz, N., Fried, H.U., Kukat, C., Peychl, J., Liebig, C., Terjung, S., Laketa, V., Sporbert, A., Weidtkamp-Peters, S., Schauss, A., Zuschratter, W. and Avilov, S.
Microscopy Research and Technique 79 (6): 463-479. June 2016

PCNA appears in two populations of slow and fast diffusion with a constant ratio throughout S-phase in replicating mammalian cells.
Zessin, P.J.M., Sporbert, A. and Heilemann, M.
Scientific Reports 6 : 18779. 13 January 2016

2015

Automated quantification of hematopoietic cell - stromal cell interactions in histological images of undecalcified bone.
Zehentmeier, S., Cseresnyes, Z., Escribano Navarro, J., Niesner, R.A. and Hauser, A.E.
Journal of Visualized Experiments (98) 8 April 2015

2014

Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation.
Heinig, K., Gätjen, M., Grau, M., Stache, V., Anagnostopoulos, I., Gerlach, K., Niesner, R.A., Cseresnyes, Z., Hauser, A.E., Lenz, P., Hehlgans, T., Brink, R., Westermann, J., Dörken, B., Lipp, M., Lenz, G., Rehm, A. and Höpken, U.E.
Cancer Discovery 4 : 1448-1465. December 2014

Highly resolved intravital striped-illumination microscopy of germinal centers.
Cseresnyes, Z., Oehme, L., Andresen, V., Sporbert, A., Hauser, A.E. and Niesner, R.
Journal of Visualized Experiments (86): e51135. 9 April 2014

2013

Simple method for sub-diffraction resolution imaging of cellular structures on standard confocal microscopes by three-photon absorption of quantum dots.
Sporbert, A., Cseresnyes, Z., Heidbreder, M., Domaing, P., Hauser, S., Kaltschmidt, B., Kaltschmidt, C., Heilemann, M. and Widera, D.
PLoS ONE 8 (5): e64023. 21 May 2013

Unilateral dampening of Bmp activity by Nodal generates cardiac left-right asymmetry.
Veerkamp, J., Rudolph, F., Cseresnyes, Z., Priller, F., Otten, C., Renz, M., Schaefer, L. and Abdelilah-Seyfried, S.
Developmental Cell 24 (6): 660-667. 25 March 2013

2012

High-resolution intravital microscopy.
Andresen, V., Pollok, K., Rinnenthal, J.L., Oehme, L., Guenther, R., Spiecker, H., Radbruch, H., Gerhard, J., Sporbert, A., Cseresnyes, Z., Hauser, A.E. and Niesner, R.
PLoS ONE 7 (12): e50915. 14 December 2012

Cell tracking using photoconvertible proteins during zebrafish development.
Lombardo, V.A., Sporbert, A. and Abdelilah-Seyfried, S.
Journal of Visualized Experiments (67): e4350. 28 September 2012

2011

Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation.
Jerke, U., Rolle, S., Dittmar, G., Bayat, B., Santoso, S., Sporbert, A., Luft, F.C. and Kettritz, R.
Journal of Biological Chemistry 286 (9): 7070-7081. 4 March 2011

2008

Uncoupling the replication machinery: Replication fork progression in the absence of processive DNA synthesis.
Goerisch, S.M., Sporbert, A., Stear, J.H., Grunewald, I., Nowak, D., Warbrick, E., Leonhardt, H. and Cardoso, M.C.
Cell Cycle 7 (13): 1983-1990. 1 July 2008

Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis.
Rohe, M., Carlo, A.S., Breyhan, H., Sporbert, A., Militz, D., Schmidt, V., Wozny, C., Harmeier, A., Erdmann, B., Bales, K.R., Wolf, S.A., Kempermann, G., Paul, S.M., Schmitz, D., Bayer, T.A., Willnow, T.E. and Andersen, O.M.
Journal of Biological Chemistry 283 (21): 14826-14834. 23 May 2008

2007

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1.
Schmidt, V., Sporbert, A., Rohe, M., Reimer, T., Rehm, A., Andersen, O.M. and Willnow, T.E.
Journal of Biological Chemistry 282 (45): 32956-32964. 9 November 2007

2005

PCNA acts as a stationary loading platform for transiently interacting Okazaki fragment maturation proteins.
Sporbert, A., Domaing, P., Leonhardt, H. and Cardoso, M.C.
Nucleic Acids Research 33 (11): 3521-3528. 21 June 2005

2002

DNA polymerase clamp shows little turnover at established replication sites but sequential de novo assembly at adjacent origin clusters.
Sporbert, A., Gahl, A., Ankerhold, R., Leonhardt, H. and Cardoso, M.C.
Molecular Cell 10 (6): 1355-1365. December 2002

2001

(NO)-N-center dot and oxyradical metabolism in new cell lines of rat brain capillary endothelial cells forming the blood-brain barrier.
Blasig, I.E., Giese, H., Schroeter, M.L., Sporbert, A., Utepbergenov, D.I., Buchwalow, I.B., Neubert, K., Schoenfelder, G., Freyer, D., Schimke, I., Siems, W.E., Paul, M., Haseloff, R.F. and Blasig, R.
Microvascular Research 62 (2): 114-127. 1 January 2001

2000

Dynamics of DNA replication factories in living cells.
Leonhardt, H., Rahn, H.P., Weinzierl, P., Sporbert, A., Cremer, T., Zink, D. and Cardoso, M.C.
Journal of Cell Biology 149 (2): 271-279. 17 April 2000

Targeting regulatory factors to intranuclear replication sites.
Leonhardt, H., Sporbert, A. and Cardoso, M.C.
Critical Reviews in Eukaryotic Gene Expression 10 : 127-133. 1 January 2000

1999

Structure and function in the nucleus: Subnuclear trafficking of DNA replication factors.
Cardoso, M.C., Sporbert, A. and Leonhardt, H.
Journal of Cellular Biochemistry Suppl. 32-33 : 15-23. 1 January 1999