Browse by Research Team

Analytical Biochemistry

Refinement of single-nucleotide polymorphism genotyping methods on human genomic DNA: amplifluor allele-specific polymerase chain reaction versus ligation detection reaction-TaqMan.
Rickert, A.M., Borodina, T.A., Kuhn, E.J., Lehrach, H. and Sperling, S.
Analytical Biochemistry 330 (2): 288-297. 15 July 2004

Archives of Medical Science

Mutations in NEBL encoding the cardiac Z-disk protein nebulette are associated with various cardiomyopathies.
Perrot, A., Tomasov, P., Villard, E., Faludi, R., Melacini, P., Lossie, J., Lohmann, N., Richard, P., De Bortoli, M., Angelini, A., Varga-Szemes, A., Sperling, S.R., Simor, T., Veselka, J., Oezcelik, C. and Charron, P.
Archives of Medical Science 12 (2): 263-278. April 2016

BMC Bioinformatics

Transcriptional regulation at a glance.
Sperling, S.
BMC Bioinformatics 8 (Suppl 6): S2. 27 September 2007

Ringo--an R/Bioconductor package for analyzing ChIP-chip readouts.
Toedling, J., Skylar, O., Krueger, T., Fischer, J.J., Sperling, S. and Huber, W.
BMC Bioinformatics 8 : 221. 26 June 2007

Chromosomal clustering of a human transcriptome reveals regulatory background.
Vogel, J.H., von Heydebreck, A., Purmann, A. and Sperling, S.
BMC Bioinformatics 6 : 230. 19 September 2005

d-matrix - database exploration, visualization and analysis.
Seelow, D., Galli, R., Mebus, S., Sperling, H.P., Lehrach, H. and Sperling, S.
BMC Bioinformatics 5 : 168. 28 October 2004

Basic Research in Cardiology

Unequal allelic expression of wild-type and mutated beta-myosin in familial hypertrophic cardiomyopathy.
Tripathi, S., Schultz, I., Becker, E., Montag, J., Borchert, B., Francino, A., Navarro-Lopez, F., Perrot, A., Oezcelik, C., Osterziel, K.J., McKenna, W.J., Brenner, B. and Kraft, T.
Basic Research in Cardiology 106 (6): 1041-1055. November 2011

Bioinformatics

MicroRazerS: rapid alignment of small RNA reads.
Emde, A.K., Grunert, M., Weese, D., Reinert, K. and Sperling, S.R.
Bioinformatics 26 (1): 123-124. 1 January 2010

Briefings in Functional Genomics

Application of high-throughput sequencing for studying genomic variations in congenital heart disease.
Dorn, C., Grunert, M. and Sperling, S.R.
Briefings in Functional Genomics 13 (1): 51-65. January 2014

Cardiovascular Research

Comparative DNA methylation and gene expression analysis identifies novel genes for structural congenital heart diseases.
Grunert, M., Dorn, C., Cui, H., Dunkel, I., Schulz, K., Schoenhals, S., Sun, W., Berger, F., Chen, W. and Sperling, S.R.
Cardiovascular Research 112 (1): 464-477. 1 October 2016

Congenital coronary artery anomalies: a bridge from embryology to anatomy and pathophysiology-a position statement of the development, anatomy, and pathology ESC Working Group.
Perez-Pomares, J.M., de la Pompa, J.L., Franco, D., Henderson, D., Ho, S.Y., Houyel, L., Kelly, R.G., Sedmera, D., Sheppard, M., Sperling, S., Thiene, G., van den Hoff, M. and Basso, C.
Cardiovascular Research 109 (2): 204-216. 1 February 2016

Systems biology approaches to heart development and congenital heart disease.
Sperling, S.R.
Cardiovascular Research 91 (2): 269-278. 15 July 2011

Circulation

Genome-wide array analysis of normal and malformed human hearts.
Kaynak, B., von Heydebreck, A., Mebus, S., Seelow, D., Hennig, S., Vogel, J., Sperling, H.P., Pregla, R., Alexi-Meskishvili, V., Hetzer, R., Lange, P.E., Vingron, M., Lehrach, H. and Sperling, S.
Circulation 107 (19): 2467-2474. 20 May 2003

Circulation Cardiovascular Genetics

ZBTB17 (MIZ1) is important for the cardiac stress response and a novel candidate gene for cardiomyopathy and heart failure.
Buyandelger, B., Mansfield, C., Kostin, S., Choi, O., Roberts, A.M., Ware, J.S., Mazzarotto, F., Pesce, F., Buchan, R., Isaacson, R.L., Vouffo, J., Gunkel, S., Knoell, G., McSweeney, S.J., Wei, H., Perrot, A., Pfeiffer, C., Toliat, M.R., Ilieva, K., Krysztofinska, E., López-Olañeta, M.M., Gómez-Salinero, J.M., Schmidt, A., Ng, K.E., Teucher, N., Chen, J., Teichmann, M., Eilers, M., Haverkamp, W., Regitz-Zagrosek, V., Hasenfuss, G., Braun, T., Pennell, D.J., Gould, I., Barton, P.J.R., Lara-Pezzi, E., Schäfer, S., Hübner, N., Felkin, L.E., O'Regan, D.P., Petretto, E., Brand, T., Milting, H., Nürnberg, P., Schneider, M.D., Prasad, S. and Knöll, R.
Circulation Cardiovascular Genetics 8 (5): 643-652. October 2015

Mutations in the sarcomere protein gene MYH7 in Ebstein's anomaly.
Postma, A.V., van Engelen, K., van de Meerakker, J., Rahman, T., Probst, S., Baars, M.J., Bauer, U., Pickardt, T., Sperling, S.R., Berger, F., Moorman, A.F., Mulder, B.J., Thierfelder, L., Keavney, B., Goodship, J. and Klaassen, S.
Circulation Cardiovascular Genetics 4 (1): 43-50. February 2011

Clinical Chemistry

Multiplexed real-time PCR using universal reporters.
Rickert, A.M., Lehrach, H. and Sperling, S.
Clinical Chemistry 50 (9): 1680-1683. September 2004

Congenital Heart Diseases: The Broken Heart

Human genetics of ventricular septal defect.
Bellmann, K., Perrot, A. and Rickert-Sperling, S.
In: Congenital Heart Diseases: The Broken Heart : Clinical Features, Human Genetics and Molecular Pathways. Springer, Vienna, 307-328. ISBN 978-3-7091-1882-5 2016

Congenital Heart Diseases: The Broken Heart : Clinical Features, Human Genetics and Molecular Pathways

Preface.
Rickert-Sperling, S., Kelly, R.G. and Driscoll, D.J.
Congenital Heart Diseases: The Broken Heart : Clinical Features, Human Genetics and Molecular Pathways : ix-x. 2016

European Heart Journal

Hypertrophic remodelling in cardiac regulatory myosin light chain (MYL2) founder mutation carriers.
Claes, G.R.F., van Tienen, F.H.J., Lindsey, P., Krapels, I.P.C., Helderman-van den Enden, A.T.J.M., Hoos, M.B., Barrois, Y.E.G., Janssen, J.W.H., Paulussen, A.D.C., Sels, J.W.E.M., Kuijpers, S.H.H., van Tintelen, J.P., van den Berg, M.P., Heesen, W.F., Garcia-Pavia, P., Perrot, A., Christiaans, I., Salemink, S., Marcelis, C.L.M., Smeets, H.J.M., Brunner, H.G., Volders, P.G.A. and van den Wijngaard, A.
European Heart Journal 37 (23): 1815-1822. 14 June 2016

European Journal of Cardio-Thoracic Surgery

A promoter polymorphism -945C>G in the connective tissue growth factor in heart failure patients with mechanical circulatory support: a new marker for bridge to recovery?
Posch, M.G., Schmidt, G., Steinhoff, L., Perrot, A., Drews, T., Dandel, M., Krabatsch, T., Hetzer, R. and Potapov, E.V.
European Journal of Cardio-Thoracic Surgery 47 (1): e29-e33. 2015

European Journal of Heart Failure

Gender-specific differences in major cardiac events and mortality in lamin A/C mutation carriers.
van Rijsingen, I.A.W., Nannenberg, E.A., Arbustini, E., Elliott, P.M., Mogensen, J., Hermans-van Ast, J.F., van der Kooi, A.J., van Tintelen, J.P., van den Berg, M.P., Grasso, M., Serio, A., Jenkins, S., Rowland, C., Richard, P., Wilde, A.A.M., Perrot, A., Pankuweit, S., Zwinderman, A.H., Charron, P., Christiaans, I. and Pinto, Y.M.
European Journal of Heart Failure 15 (4): 376-384. April 2013

European Journal of Human Genetics

Doubly heterozygous LMNA and TTN mutations revealed by exome sequencing in a severe form of dilated cardiomyopathy.
Roncarati, R., Viviani Anselmi, C., Krawitz, P., Lattanzi, G., von Kodolitsch, Y., Perrot, A., di Pasquale, E., Papa, L., Portararo, P., Columbaro, M., Forni, A., Faggian, G., Condorelli, G. and Robinson, P.N.
European Journal of Human Genetics 21 (10): 1105-1111. October 2013

Novel mutations in the sarcomeric protein myopalladin in patients with dilated cardiomyopathy.
Meyer, T., Ruppert, V., Ackermann, S., Richter, A., Perrot, A., Sperling, S.R., Posch, M.G., Maisch, B. and Pankuweit, S.
European Journal of Human Genetics 21 (3): 294-300. March 2013

Evolution & Development

The proepicardium keeps a potential for glomerular marker expression which supports its evolutionary origin from the pronephros.
Cano, E., Carmona, R., Velecela, V., Martinez-Estrada, O. and Munoz-Chapuli, R.
Evolution & Development 17 (4): 224-230. July 2015

Genes & Development

Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.
Lange, M., Kaynak, B., Foerster, U.B., Toenjes, M., Fischer, J.J., Grimm, C., Schlesinger, J., Just, S., Dunkel, I., Krueger, T., Mebus, S., Lehrach, H., Lurz, R., Gobom, J., Rottbauer, W., Abdelilah-Seyfried, S. and Sperling, S.
Genes & Development 22 (17): 2370-2384. 1 September 2008

Genome Biology

From single cells to whole organisms.
Sperling, S.
Genome Biology 6 (13): 365. 2005

Genome Informatics

A new statistical model to select target sequences bound by transcription factors.
Pape, U.J., Grossmann, S., Hammer, S., Sperling, S. and Vingron, M.
Genome Informatics 17 (1): 134-140. 2006

Genomics

Combinatorial effects of four histone modifications in transcription and differentiation.
Fischer, J.J., Toedling, J., Krueger, T., Schueler, M., Huber, W. and Sperling, S.
Genomics 91 (1): 41-51. January 2008

Genomic organization of transcriptomes in mammals: Coregulation and cofunctionality.
Purmann, A., Toedling, J., Schueler, M., Carninci, P., Lehrach, H., Hayashizaki, Y., Huber, W. and Sperling, S.
Genomics 89 (5): 580-587. May 2007

Heart Rhythm

CRISPR correction of the PRKAG2 gene mutation in the patient's iPSC-derived cardiomyocytes eliminates the electrophysiological and structural abnormalities.
Ben Jehuda, R., Eisen, B., Shemer, Y., Mekies, L.N., Szantai, A., Reiter, I., Cui, H., Guan, K., Haron-Khun, S., Freimark, D., Sperling, S.R., Gherghiceanu, M., Arad, M. and Binah, O.
Heart Rhythm 15 (2): 267-276. February 2018

Human Molecular Genetics

Rare and private variations in neural crest, apoptosis and sarcomere genes define the polygenic background of isolated Tetralogy of Fallot.
Grunert, M., Dorn, C., Schueler, M., Dunkel, I., Schlesinger, J., Mebus, S., Alexi-Meskishvili, V., Perrot, A., Wassilew, K., Timmermann, B., Hetzer, R., Berger, F. and Sperling, S.R.
Human Molecular Genetics 23 (12): 3115-3128. 15 June 2014

Triple A syndrome is caused by mutations in AAAS, a new WD-repeat protein gene.
Handschug, K., Sperling, S., Yoon, S.J., Hennig, S., Clark, A.J. and Huebner, A.
Human Molecular Genetics 10 (3): 283-290. 1 February 2001

Human Mutation

Identification and functional analysis of CITED2 mutations in patients with congenital heart defects.
Sperling, S., Grimm, C.H., Dunkel, I., Mebus, S., Sperling, H.P., Ebner, A., Galli, R., Lehrach, H., Fusch, C., Berger, F. and Hammer, S.
Human Mutation 26 (6): 575-582. December 2005

International Journal of Cardiology

Variations in the human soluble epoxide hydrolase gene and recurrence of atrial fibrillation after catheter ablation.
Wutzler, A., Kestler, C., Perrot, A., Loehr, L., Huemer, M., Parwani, A.S., Attanasio, P., Özcelik, C., Schunck, W.H., Gollasch, M., Haverkamp, W. and Boldt, L.H.
International Journal of Cardiology 168 (4): 3647-3651. 9 October 2013

Journal of Cellular Biochemistry

Characterization of TBX20 in human hearts and its regulation by TFAP2.
Hammer, S., Toenjes, M., Lange, M., Fischer, J.J., Dunkel, I., Mebus, S., Grimm, C.H., Hetzer, R., Berger, F. and Sperling, S.
Journal of Cellular Biochemistry 104 (3): 1022-1033. 1 June 2008

Journal of Molecular and Cellular Cardiology

Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes.
Streckfuss-Boemeke, K., Tiburcy, M., Fomin, A., Luo, X., Li, W., Fischer, C., Oezcelik, C., Perrot, A., Sossalla, S., Haas, J., Vidal, R.O., Rebs, S., Khadjeh, S., Meder, B., Bonn, S., Linke, W.A., Zimmermann, W.H., Hasenfuss, G. and Guan, K.
Journal of Molecular and Cellular Cardiology 113 : 9-21. December 2017

Journal of Muscle Research and Cell Motility

Intrinsic MYH7 expression regulation contributes to tissue level allelic imbalance in hypertrophic cardiomyopathy.
Montag, J., Syring, M., Rose, J., Weber, A.L., Ernstberger, P., Mayer, A.K., Becker, E., Keyser, B., Dos Remedios, C., Perrot, A., van der Velden, J., Francino, A., Navarro-Lopez, F., Ho, C.Y., Brenner, B. and Kraft, T.
Journal of Muscle Research and Cell Motility 38 (3-4): 291-302. August 2017

Journal of the American College of Cardiology

Risk factors for malignant ventricular arrhythmias in lamin A/C mutation carriers a European cohort study.
van Rijsingen, I.A.W., Arbustini, E., Elliott, P.M., Mogensen, J., Hermans-van Ast, J.F., van der Kooi, A.J., van Tintelen, J.P., van den Berg, M.P., Pilotto, A., Pasotti, M., Jenkins, S., Rowland, C., Aslam, U., Wilde, A.A.M., Perrot, A., Pankuweit, S., Zwinderman, A.H., Charron, P. and Pinto, Y.M.
Journal of the American College of Cardiology 59 (5): 493-500. 31 January 2012

Methods

Evaluation of the LightCycler 1536 Instrument for high-throughput quantitative real-time PCR.
Schlesinger, J., Toenjes, M., Schueler, M., Zhang, Q., Dunkel, I. and Sperling, S.R.
Methods 50 (4): S19-S22. April 2010

Methods in Molecular Medicine

Array analysis applied to malformed hearts: Molecular dissection of tetralogy of Fallot.
Sperling, S.
Methods in Molecular Medicine 1 (126): 233-246. 2006

Molecular BioSystems

Dynamics of Srf, p300 and histone modifications during cardiac maturation in mouse.
Schueler, M., Zhang, Q., Schlesinger, J., Toenjes, M. and Sperling, S.R.
Molecular BioSystems 8 (2): 495-503. February 2012

Prediction of cardiac transcription networks based on molecular data and complex clinical phenotypes.
Toenjes, M., Schueler, M., Hammer, S., Pape, U.J., Fischer, J.J., Berger, F., Vingron, M. and Sperling, S.
Molecular BioSystems 4 (6): 589-598. June 2008

Nature Cardiovascular Research

BLN protein induces cardiac hypertrophy and failure.
Sperling, S.R.
Nature Cardiovascular Research 2 (11): 964-965. November 2023

Netherlands Heart Journal

Ebstein's anomaly may be caused by mutations in the sarcomere protein gene MYH7.
van Engelen, K., Postma, A.V., van de Meerakker, J.B.A., Roos-Hesselink, J.W., Helderman-van den Enden, A.T.J.M., Vliegen, H.W., Rahman, T., Baars, M.J.H., Sels, J.W., Bauer, U., Pickardt, T., Sperling, S.R., Moorman, A.F.M., Keavney, B., Goodship, J., Klaassen, S. and Mulder, B.J.
Netherlands Heart Journal 21 (3): 113-117. March 2013

Nucleic Acids Research

Phosphorylation of the chromatin remodeling factor DPF3a induces cardiac hypertrophy through releasing HEY repressors from DNA.
Cui, H., Schlesinger, J., Schoenhals, S., Toenjes, M., Dunkel, I., Meierhofer, D., Cano, E., Schulz, K., Berger, M.F., Haack, T., Abdelilah-Seyfried, S., Bulyk, M.L., Sauer, S. and Sperling, S.R.
Nucleic Acids Research 44 (6): 2538-2553. 7 April 2016

PLoS Genetics

The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs.
Schlesinger, J., Schueler, M., Grunert, M., Fischer, J.J., Zhang, Q., Krueger, T., Lange, M., Toenjes, M., Dunkel, I. and Sperling, S.R.
PLoS Genetics 7 (2): e1001313. February 2011

Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells.
Juerchott, K., Kuban, R.J., Krech, T., Blüthgen, N., Stein, U., Walther, W., Friese, C., Kielbasa, S.M., Ungethuem, U., Lund, P., Knoesel, T., Kemmner, W., Morkel, M., Fritzmann, J., Schlag, P.M., Birchmeier, W., Krueger, T., Sperling, S., Sers, C., Royer, H.D., Herzel, H. and Schaefer, R.
PLoS Genetics 6 (12): e1001231. 2 December 2010

PLoS ONE

Muscle-relevant genes marked by stable H3K4me2/3 profiles and enriched MyoD binding during myogenic differentiation.
Cui, H., Bansal, V., Grunert, M., Malecova, B., Dall Agnese, A., Latella, L., Gatto, S., Ryan, T., Schulz, K., Chen, W., Dorn, C., Puri, P.L. and Sperling, S.R.
PLoS ONE 12 (6): e0179464. 13 June 2017

Outlier-based identification of copy number variations using targeted resequencing in a small cohort of patients with tetralogy of fallot.
Bansal, V., Dorn, C., Grunert, M., Klaassen, S., Hetzer, R., Berger, F. and Sperling, S.R.
PLoS ONE 9 (1): e85375. 6 January 2014

Cardiac alpha-myosin (MYH6) is the predominant sarcomeric disease gene for familial atrial septal defects.
Posch, M.G., Waldmuller, S., Mueller, M., Scheffold, T., Fournier, D., Andrade-Navarro, M.A., De Geeter, B., Guillaumont, S., Dauphin, C., Yousseff, D., Schmitt, K.R., Perrot, A., Berger, F., Hetzer, R., Bouvagnet, P. and Ozcelik, C.
PLoS ONE 6 (12): e28872. 14 December 2011

The effect of micrococcal nuclease digestion on nucleosome positioning data.
Chung, H.R., Dunkel, I., Heise, F., Linke, C., Krobitsch, S., Ehrenhofer-Murray, A.E., Sperling, S.R. and Vingron, M.
PLoS ONE 5 (12): e15754. 29 December 2010

Pediatric Cardiology

CCN1 mutation is associated with atrial septal defect.
Perrot, A., Schmitt, K.R., Roth, E.M., Stiller, B., Posch, M.G., Browne, E.N.L., Timmann, C., Horstmann, R.D., Berger, F. and Ozcelik, C.
Pediatric Cardiology 36 (2): 295-299. February 2015

Pediatric Research

BMPR IA downstream genes related to VSD.
Yang, D., Zhang, J., Chen, C., Xie, M., Sperling, S., Fang, F., Chen, B., Li, X. and Zhang, H.
Pediatric Research 63 (6): 602-606. June 2008

Physiological Genomics

A physiogenomic approach to study the regulation of blood pressure.
Westhoff, T.H., Scheid, S., Toelle, M., Kaynak, B., Schmidt, S., Zidek, W., Sperling, S. and van der Giet, M.
Physiological Genomics 23 (1): 46-53. 21 September 2005

Science

Diverging roads to the heart.
Kelly, R.G. and Sperling, S.R.
Science 359 (6380): 1098-1099. 9 March 2018

The transcriptional landscape of the mammalian genome.
Carninci, P., Kasukawa, T., Katayama, S., Gough, J., Frith, M.C., Maeda, N., Oyama, R., Ravasi, T., Lenhard, B., Wells, C., Kodzius, R., Shimokawa, K., Bajic, V.B., Brenner, S.E., Batalov, S., Forrest, A.R.R., Zavolan, M., Davis, M.J., Wilming, L.G., Aidinis, V., Allen, J.E., Ambesi-Impiombato, A., Apweiler, R., Aturaliya, R.N., Bailey, T.L., Bansal, M., Baxter, L., Beisel, K.W., Bersano, T., Bono, H., Chalk, A.M., Chiu, K.P., Choudhary, V., Christoffels, A., Clutterbuck, D.R., Crowe, M.L., Dalla, E., Dalrymple, B.P., de Bono, B., Della Gatta, G., di Bernardo, D., Down, T., Engstrom, P., Fagiolini, M., Faulkner, G., Fletcher, C.F., Fukushima, T., Furuno, M., Futaki, S., Gariboldi, M., Georgii-Hemming, P., Gingeras, G.R., Gojobori, T., Green, R.E., Gustincich, S., Harbers, M., Hayashi, Y., Hensch, T.K., Hirokawa, N., Hill, D., Huminiecki, L., Iacono, I., Ikeo, K., Iwama, A., Ishikawa, T., Jakt, M., Kanapin, A., Katoh, M., Kawasawa, Y., Kelso, J., Kitamura, H., Kitano, H., Kollias, G., Krishnan, S.P.T., Kruger, A., Kummerfeld, S.K., Kurochkin, I.V., Lareau, L.F., Lazarevic, D., Lipovich, L., Liu, J., Liuni, S., McWilliam, S., Madan Babu, M., Madera, M., Marchionni, L., Matsuda, H., Matsuzawa, S., Miki, H., Mignone, F., Miyake, S., Morris, K., Mottagui-Tabar, S., Mulder, N., Nakano, N., Nakauchi, H., Ng, P., Nilsson, R., Nishiguchi, S., Nishikawa, S., Nori, F., Ohara, O., Okazaki, Y., Orlando, V., Pang, K.C., Pavan, W.J., Pavesi, G., Pesole, G., Petrovsky, N., Piazza, S., Reed, J., Reid, J.F., Ring, B.Z., Ringwald, M., Rost, B., Ruan, Y., Salzberg, S.L., Sandelin, A., Schneider, C., Schönbach, C., Sekiguchi, S., Semple, C.A.M., Seno, S., Sessa, L., Sheng, Y., Shibata, Y., Shimada, H., Shimada, K., Silva, D., Sinclair, B., Sperling, S., Stupka, E., Sugiura, S., Sultana, R., Takenaka, Y., Taki, K., Tammoja, K., Tan, S.L., Tang, S., Taylor, M.S., Tegner, J., Teichmann, S.A., Ueda, H.R., van Nimwegen, E., Verardo, R., Wei, C.L., Yagi, K., Yamanishi, H., Zabarovsky, E., Zhu, S., Zimmer, A., Hide, W., Bult, C., Grimmond, S.M., Teasdale, R.D., Liu, E.T., Brusic, V., Quackenbush, J., Wahlestedt, C., Mattick, J.S., Hume, D.A., Kai, C., Sasaki, D., Tomaru, Y., Fukuda, S., Kanamori-Katayama, M., Suzuki, M., Aoki, J., Arakawa, T., Iida, J., Imamura, K., Itoh, M., Kato, T., Kawaji, H., Kawagashira, N., Kawashima, T., Kojima, M., Kondo, S., Konno, H., Nakano, K., Ninomiya, N., Nishio, T., Okada, M., Plessy, C., Shibata, K., Shiraki, T., Suzuki, S., Tagami, M., Waki, K., Watahiki, A., Okamura-Oho, Y., Suzuki, H., Kawai, J. and Hayashizaki, Y.
Science 309 (5740): 1559-1563. 2 September 2005