Browse by Research Team

Acta Physiologica

Biomarkers in acute kidney injury - pathophysiological basis and clinical performance.
Schrezenmeier, E.V., Barasch, J., Budde, K., Westhoff, T. and Schmidt-Ott, K.M.
Acta Physiologica 219 (3): 554-572. March 2017

Novel signalling mechanisms and targets in renal ischaemia and reperfusion injury.
Kusch, A., Hoff, U., Bubalo, G., Zhu, Y., Fechner, M., Schmidt-Ullrich, R., Marko, L., Müller, D.N., Schmidt-Ott, K.M., Gürgen, D., Blum, M., Schunck, W.H. and Dragun, D.
Acta Physiologica 208 (1): 25-40. May 2013

Calprotectin and neutrophil gelatinase-associated lipocalin in the differentiation of pre-renal and intrinsic acute kidney injury.
Seibert, F.S., Pagonas, N., Arndt, R., Heller, F., Dragun, D., Persson, P., Schmidt-Ott, K., Zidek, W. and Westhoff, T.H.
Acta Physiologica 207 (4): 700-708. April 2013

Neutrophil gelatinase-associated lipocalin: pathophysiology and clinical applications.
Singer, E., Markó, L., Paragas, N., Barasch, J., Dragun, D., Müller, D.N., Budde, K. and Schmidt-Ott, K.M.
Acta Physiologica 207 (4): 663-672. April 2013

American Journal of Human Genetics

Localization of a gene for nonsyndromic renal hypodysplasia to chromosome 1p32-33.
Sanna-Cherchi, S., Caridi, G., Weng, P.L., Dagnino, M., Seri, M., Konka, A., Somenzi, D., Carrea, A., Izzi, C., Casu, D., Allegri, L., Schmidt-Ott, K.M., Barasch, J., Scolari, F., Ravazzolo, R., Ghiggeri, G.M. and Gharavi, A.G.
American Journal of Human Genetics 80 (3): 539-549. March 2007

American Journal of Physiology Cell Physiology

Acute kidney injury biomarkers in the single cell transcriptomic era.
Hinze, C. and Schmidt-Ott, K.M.
American Journal of Physiology Cell Physiology 323 (5): C1430-C1443. 9 November 2022

Detection of intracellular iron by its regulatory effect.
Li, J.Y., Ram, G., Gast, K., Chen, X., Barasch, K., Mori, K., Schmidt-Ott, K., Wang, J., Kuo, H.C., Savage-Dunn, C., Garrick, M.D. and Barasch, J.
American Journal of Physiology Cell Physiology 287 (6): C1547-C1549. December 2004

Annals of the New York Academy of Sciences

Transcriptional mechanisms coordinating tight junction assembly during epithelial differentiation.
Boivin, F.J. and Schmidt-Ott, K.
Annals of the New York Academy of Sciences 1397 (1): 80-99. June 2017

Antioxidants & Redox Signaling

Redox regulation of cell contacts by tricellulin and occludin: redox-sensitive cysteine sites in tricellulin regulate both tri- and bicellular junctions in tissue barriers as shown in hypoxia and ischemia.
Cording, J., Günther, R., Vigolo, E., Tscheik, C., Winkler, L., Schlattner, I., Lorenz, D., Haseloff, R.F., Schmidt-Ott, K.M., Wolburg, H. and Blasig, I.E.
Antioxidants & Redox Signaling 23 (13): 1035-1049. 5 November 2015

BMC Genomics

Discovery of a non-canonical GRHL1 binding site using deep convolutional and recurrent neural networks.
Proft, S., Leiz, J., Heinemann, U., Seelow, D., Schmidt-Ott, K.M. and Rutkiewicz, M.
BMC Genomics 24 (1): 736. 4 December 2023

BMC Urology

Limited utility of qPCR-based detection of tumor-specific circulating mRNAs in whole blood from clear cell renal cell carcinoma patients.
Simonovic, S., Hinze, C., Schmidt-Ott, K.M., Busch, J., Jung, M., Jung, K. and Rabien, A.
BMC Urology 20 (1): 7. 4 February 2020

BioEssays

The basal chorionic trophoblast cell layer: an emerging coordinator of placenta development.
Walentin, K., Hinze, C. and Schmidt-Ott, K.M.
BioEssays 38 (3): 254-265. March 2016

Blood Pressure

Current practice of blood pressure measurement in Germany: a nationwide questionnaire-based survey in medical practices.
Beger, C., Mayerböck, A., Klein, K., Karg, T., Schmidt-Ott, K.M., Randerath, O. and Limbourg, F.P.
Blood Pressure 32 (1): 2165901. 2023

Blood Purification

Pathophysiology of the cardiorenal syndromes: executive summary from the Eleventh Consensus Conference of the Acute Dialysis Quality Initiative (ADQI).
McCullough, P.A., Kellum, J.A., Haase, M., Mueller, C., Damman, K., Murray, P.T., Cruz, D., House, A.A., Schmidt-Ott, K.M., Vescovo, G., Bagshaw, S.M., Hoste, E.A., Briguori, C., Braam, B., Chawla, L.S., Costanzo, M.R., Tumlin, J.A., Herzog, C.A., Mehta, R.L., Rabb, H., Shaw, A.D., Singbartl, K. and Ronco, C.
Blood Purification 37 (Suppl 2): 2-13. 31 July 2014

Cancer Biology & Therapy

Mechanically activated ion channel Piezo1 contributes to melanoma malignant progression through AKT/mTOR signaling.
Zhang, S., Cao, S., Gong, M., Zhang, W., Zhang, W., Zhu, Z., Wu, S., Yue, Y., Qian, W., Ma, Q., Wang, S. and Wang, Z.
Cancer Biology & Therapy 23 (1): 336-347. 22 April 2022

Cancer Research

Multiple imprinted and stemness genes provide a link between normal and tumor progenitor cells of the developing human kidney.
Dekel, B., Metsuyanim, S., Schmidt-Ott, K.M., Fridman, E., Jacob-Hirsch, J., Simon, A., Pinthus, J., Mor, Y., Barasch, J., Amariglio, N. and Reisner, Y.
Cancer Research 66 (12): 6040-6049. 15 June 2006

Cancers

Hypertonicity-affected genes are differentially expressed in clear cell renal cell carcinoma and correlate with cancer-specific survival.
Kandabarau, S., Leiz, J., Krohn, K., Winter, S., Bedke, J., Schwab, M., Schaeffeler, E. and Edemir, B.
Cancers 12 (1): 6. 18 December 2019

Cellular and Molecular Immunology

Insm1 regulates mTEC development and immune tolerance.
Tao, W., Ye, Z., Wei, Y., Wang, J., Yang, W., Yu, G., Xiong, J. and Jia, S.
Cellular and Molecular Immunology 20 (12): 1472-1486. December 2023

Cellular and Molecular Life Sciences

Parallel generation of easily selectable multiple nephronal cell types from human pluripotent stem cells.
Hariharan, K., Stachelscheid, H., Rossbach, B., Oh, S.J., Mah, N., Schmidt-Ott, K., Kurtz, A. and Reinke, P.
Cellular and Molecular Life Sciences 76 (1): 179-192. January 2019

Contributions to Nephrology

Pathophysiology of cardiorenal syndrome type 2 in stable chronic heart failure: workgroup statements from the eleventh consensus conference of the Acute Dialysis Quality Initiative (ADQI).
Cruz, D.N., House, A.A., Schmidt-Ott, K.M., Vescovo, G., Kellum, J.A., Ronco, C. and McCullough, P.A.
Contributions to Nephrology 182 : 117-136. 2013

Pathophysiology of the cardiorenal syndromes: executive Summary from the Eleventh Consensus Conference of the Acute Dialysis Quality Initiative (ADQI).
McCullough, P.A., Kellum, J.A., Haase, M., Müller, C., Damman, K., Murray, P.T., Cruz, D., House, A.A., Schmidt-Ott, K.M., Vescovo, G., Bagshaw, S.M., Hoste, E.A., Briguori, C., Braam, B., Chawla, L.S., Costanzo, M.R., Tumlin, J.A., Herzog, C.A., Mehta, R.L., Rabb, H., Shaw, A.D., Singbartl, K. and Ronco, C.
Contributions to Nephrology 182 : 82-98. 2013

Current Opinion in Nephrology and Hypertension

Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia.
Schmidt-Ott, K.M., Mori, K., Kalandadze, A., Li, J.Y., Paragas, N., Nicholas, T., Devarajan, P. and Barasch, J.
Current Opinion in Nephrology and Hypertension 15 (4): 442-449. July 2006

Deutsche Medizinische Wochenschrift

Prävention des akuten Nierenversagens [Prevention of acute kidney injury].
Schmidt-Ott, K.M. and Swolinsky, J.
Deutsche Medizinische Wochenschrift 147 (5): 236-245. March 2022

Akute Nierenschädigung - Update 2021 [Acute kidney injury - update 2021].
Schmidt-Ott, K.M.
Deutsche Medizinische Wochenschrift 146 (15): 988-993. August 2021

Deutsches Aerzteblatt International

The incidence of acute kidney injury and associated hospital mortality: a retrospective cohort study of over 100 000 patients at Berlin's Charité Hospital.
Khadzhynov, D., Schmidt, D., Hardt, J., Rauch, G., Gocke, P., Eckardt, K.U. and Schmidt-Ott, K.M.
Deutsches Aerzteblatt International 116 (22): 397-404. 31 May 2019

Development

A Grhl2-dependent gene network controls trophoblast branching morphogenesis.
Walentin, K., Hinze, C., Werth, M., Haase, N., Varma, S., Morell, R., Aue, A., Pötschke, E., Warburton, D., Qiu, A., Barasch, J., Purfürst, B., Dieterich, C., Popova, E., Bader, M., Dechend, R., Staff, A.C., Yurtdas, Z.Y., Kilic, E. and Schmidt-Ott, K.M.
Development 142 (6): 1125-1136. 15 March 2015

The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex.
Werth, M., Walentin, K., Aue, A., Schoenheit, J., Wuebken, A., Pode-Shakked, N., Vilianovitch, L., Erdmann, B., Dekel, B., Bader, M., Barasch, J., Rosenbauer, F., Luft, F.C. and Schmidt-Ott, K.M.
Development 137 (22): 3835-3845. November 2010

beta-catenin/TCF/Lef controls a differentiation-associated transcriptional program in renal epithelial progenitors.
Schmidt-Ott, K.M., Masckauchan, T.N.H., Chen, X., Hirsh, B.J., Sarkar, A., Yang, J., Paragas, N., Wallace, V.A., Dufort, D., Pavlidis, P., Jagla, B., Kitajewski, J. and Barasch, J.
Development 134 (17): 3177-3190. September 2007

Developmental Biology

The tyrosine phosphatase Shp2 acts downstream of GDNF/Ret in branching morphogenesis of the developing mouse kidney.
Willecke, R., Heuberger, J., Grossmann, K., Michos, O., Schmidt-Ott, K., Walentin, K., Costantini, F. and Birchmeier, W.
Developmental Biology 360 (2): 310-307. 15 December 2011

c-kit delineates a distinct domain of progenitors in the developing kidney.
Schmidt-Ott, K.M., Chen, X., Paragas, N., Levinson, R.S., Mendelsohn, C.L. and Barasch, J.
Developmental Biology 299 (1): 238-249. 1 November 2006

Developmental Cell

Scara5 is a ferritin receptor mediating non-transferrin iron delivery.
Li, J.Y., Paragas, N., Ned, R.M., Qiu, A., Viltard, M., Leete, T., Drexler, I.R., Chen, X., Sanna-Cherchi, S., Mohammed, F., Williams, D., Lin, C.S., Schmidt-Ott, K.M., Andrews, N.C. and Barasch, J.
Developmental Cell 16 (1): 35-46. 20 January 2009

Dialyse aktuell

AKI-Alerts.
Khadzhynov, D., Schmidt, D. and Schmidt-Ott, K.
Dialyse aktuell 24 (7): 265-269. September 2020

Disease Models & Mechanisms

The IgCAM CLMP regulates expression of Connexin43 and Connexin45 in intestinal and ureteral smooth muscle contraction in mice.
Langhorst, H., Jüttner, R., Groneberg, D., Mohtashamdolatshahi, A., Pelz, L., Purfürst, B., Schmidt-Ott, K.M., Friebe, A. and Rathjen, F.G.
Disease Models & Mechanisms 11 (2): dmm032128. 22 February 2018

ESC Heart Failure

Discordance between estimated and measured changes in plasma volume among patients with acute heart failure.
Swolinsky, J.S., Tuvshinbat, E., Leistner, D.M., Edelmann, F., Knebel, F., Nerger, N.P., Lemke, C., Roehle, R., Haase, M., Costanzo, M.R., Rauch, G., Mitrovic, V., Gasanin, E., Meier, D., McCullough, P.A., Eckardt, K.U., Molitoris, B.A. and Schmidt-Ott, K.M.
ESC Heart Failure 9 (1): 66-76. February 2022

Serum creatinine and cystatin C-based estimates of glomerular filtration rate are misleading in acute heart failure.
Swolinsky, J.S., Nerger, N.P., Leistner, D.M., Edelmann, F., Knebel, F., Tuvshinbat, E., Lemke, C., Roehle, R., Haase, M., Costanzo, M.R., Rauch, G., Mitrovic, V., Gasanin, E., Meier, D., McCullough, P.A., Eckardt, K.U., Molitoris, B.A. and Schmidt-Ott, K.M.
ESC Heart Failure 8 (4): 3070-3081. August 2021

Environmental Microbiology

Microbial communities along biogeochemical gradients in a hydrocarbon-contaminated aquifer.
Tischer, K., Kleinsteuber, S., Schleinitz, K.M., Fetzer, I., Spott, O., Stange, F., Lohse, U., Franz, J., Neumann, F., Gerling, S., Schmidt, C., Hasselwander, E., Harms, H. and Wendeberg, A.
Environmental Microbiology 15 (9): 2603-2615. September 2013

European Respiratory Journal

Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke, K., Obermayer, B., Mache, C., Fathykova, D., Kessler, M., Dökel, S., Wyler, E., Baumgardt, M., Löwa, A., Hoffmann, K., Graff, P., Schulze, J., Mieth, M., Hellwig, K., Demir, Z., Biere, B., Brunotte, L., Mecate-Zambrano, A., Bushe, J., Dohmen, M., Hinze, C., Elezkurtaj, S., Tönnies, M., Bauer, T.T., Eggeling, S., Tran, H.L., Schneider, P., Neudecker, J., Rückert, J.C., Schmidt-Ott, K.M., Busch, J., Klauschen, F., Horst, D., Radbruch, H., Radke, J., Heppner, F., Corman, V.M., Niemeyer, D., Müller, M.A., Goffinet, C., Mothes, R., Pascual-Reguant, A., Hauser, A.E., Beule, D., Landthaler, M., Ludwig, S., Suttorp, N., Witzenrath, M., Gruber, A.D., Drosten, C., Sander, L.E., Wolff, T., Hippenstiel, S. and Hocke, A.C.
European Respiratory Journal 60 (6): 2102725. 1 December 2022

FASEB Journal

Hypoxia reverses dibutyryl-cAMP-induced stellation of cultured astrocytes via activation of the endothelin system.
Schmidt-Ott, K.M., Xu, A.D., Tuschick, S., Liefeldt, L., Kresse, W., Verkhratsky, A., Kettenmann, H. and Paul, M.
FASEB Journal 15 (7): 1227-1229. May 2001

Frontiers in Cell and Developmental Biology

Assembling kidney tissues from cells: the long road from organoids to organs.
Hariharan, K., Kurtz, A. and Schmidt-Ott, K.M.
Frontiers in Cell and Developmental Biology 3 : 70. 11 November 2015

Genome Medicine

Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury.
Hinze, C., Kocks, C., Leiz, J., Karaiskos, N., Boltengagen, A., Cao, S., Skopnik, C.M., Klocke, J., Hardenberg, J.H., Stockmann, H., Gotthardt, I., Obermayer, B., Haghverdi, L., Wyler, E., Landthaler, M., Bachmann, S., Hocke, A.C., Corman, V., Busch, J., Schneider, W., Himmerkus, N., Bleich, M., Eckardt, K.U., Enghard, P., Rajewsky, N. and Schmidt-Ott, K.M.
Genome Medicine 14 (1): 103. 9 September 2022

Human Molecular Genetics

Predominant patterns of splicing evolution on human, chimpanzee, and macaque evolutionary lineages.
Xiong, J., Xi, J., Ditsiou, A., Gao, Y., Sun, J., Lowenstein, E.D., Huang, S. and Khaitovich, P.
Human Molecular Genetics 27 (8): 1474-1485. 15 April 2018

Hypertension

Vigilant vector: heart-specific promoter in an adeno-associated virus vector for cardioprotection.
Phillips, M.I., Tang, Y., Schmidt-Ott, K., Qian, K. and Kagiyama, S.
Hypertension 39 (2 Pt 2): 651-655. February 2002

Immunity

Epigenomic profiling of human CD4(+) T cells supports a linear differentiation model and highlights molecular regulators of memory development.
Durek, P., Nordström, K., Gasparoni, G., Salhab, A., Kressler, C., de Almeida, M., Bassler, K., Ulas, T., Schmidt, F., Xiong, J., Glažar, P., Klironomos, F., Sinha, A., Kinkley, S., Yang, X., Arrigoni, L., Amirabad, A.., Ardakani, F.B., Feuerbach, L., Gorka, O., Ebert, P., Müller, F., Li, N., Frischbutter, S., Schlickeiser, S., Cendon, C., Fröhler, S., Felder, B., Gasparoni, N., Imbusch, C.D., Hutter, B., Zipprich, G., Tauchmann, Y., Reinke, S., Wassilew, G., Hoffmann, U., Richter, A.S., Sieverling, L., Chang, H.D., Syrbe, U., Kalus, U., Eils, J., Brors, B., Manke, T., Ruland, J., Lengauer, T., Rajewsky, N., Chen, W., Dong, J., Sawitzki, B., Chung, H.R., Rosenstiel, P., Schulz, M.H., Schultze, J.L., Radbruch, A., Walter, J., Hamann, A. and Polansky, J.K.
Immunity 45 (5): 1148-1161. 15 November 2016

Innere Medizin

Was ist gesichert in der Therapie der chronischen Nierenerkrankung? [What is confirmed in the treatment of chronic kidney disease?].
Greite, R. and Schmidt-Ott, K.
Innere Medizin 63 (12): 237-1243. December 2022

International Journal of Molecular Sciences

The role of centrosome distal appendage proteins (DAPs) in nephronophthisis and ciliogenesis.
Mansour, F., Boivin, F.J., Shaheed, I.B., Schueler, M. and Schmidt-Ott, K.M.
International Journal of Molecular Sciences 22 (22): 12253. 12 November 2021

Claudins in the renal collecting duct.
Leiz, J. and Schmidt-Ott, K.M.
International Journal of Molecular Sciences 21 (1): 221. 2020

Journal for ImmunoTherapy of Cancer

Acute kidney injury in patients treated with immune checkpoint inhibitors.
Gupta, S., Short, S.A.P., Sise, M.E., Prosek, J.M., Madhavan, S.M., Soler, M.J., Ostermann, M., Herrmann, S.M., Abudayyeh, A., Anand, S., Glezerman, I., Motwani, S.S., Murakami, N., Wanchoo, R., Ortiz-Melo, D.I., Rashidi, A., Sprangers, B., Aggarwal, V., Malik, A.B., Loew, S., Carlos, C.A., Chang, W.T., Beckerman, P., Mithani, Z., Shah, C.V., Renaghan, A.D., Seigneux, S.D., Campedel, L., Kitchlu, A., Shin, D.S., Rangarajan, S., Deshpande, P., Coppock, G., Eijgelsheim, M., Seethapathy, H., Lee, M.D., Strohbehn, I.A., Owen, D.H., Husain, M., Garcia-Carro, C., Bermejo, S., Lumlertgul, N., Seylanova, N., Flanders, L., Isik, B., Mamlouk, O., Lin, J.S., Garcia, P., Kaghazchi, A., Khanin, Y., Kansal, S.K., Wauters, E., Chandra, S., Schmidt-Ott, K.M., Hsu, R.K., Tio, M.C., Sarvode Mothi, S., Singh, H., Schrag, D., Jhaveri, K.D., Reynolds, K.L., Cortazar, F.B. and Leaf, D.E.
Journal for ImmunoTherapy of Cancer 9 (10): e003467. October 2021

Journal of Cardiothoracic and Vascular Anesthesia

Cardiac surgery-related acute kidney injury - risk factors, clinical course, management suggestions.
Just, I.A., Alborzi, F., Godde, M., Ott, S., Meyer, A., Stein, J., Mazgareanu, S., van der Giet, M., Schmidt-Ott, K.M., Falk, V. and Schoenrath, F.
Journal of Cardiothoracic and Vascular Anesthesia 36 (2): 444-451. February 2022

Journal of Cardiovascular Pharmacology

Single-cell characterization of endothelin system gene expression in the cerebellum in situ.
Schmidt-Ott, K.M., Tuschick, S., Kirchhoff, F., Verkhratsky, A., Liefeldt, L., Kettenmann, H. and Paul, M.
Journal of Cardiovascular Pharmacology 31 (Suppl 1): S364-S366. 1998

Transcriptional regulation of endothelin-1 by erythropoietin in endothelial cells.
Liefeldt, L., Schmidt-Ott, K.M., Orzechowski, H.D., Distler, A. and Paul, M.
Journal of Cardiovascular Pharmacology 31 (Suppl 1): S464-S466. 1998

Journal of Clinical Investigation

α-intercalated cells defend the urinary system from bacterial infection.
Paragas, N., Kulkarni, R., Werth, M., Schmidt-Ott, K.M., Forster, C., Deng, R., Zhang, Q., Singer, E., Klose, A.D., Shen, T.H., Francis, K.P., Ray, S., Vijayakumar, S., Seward, S., Bovino, M.E., Xu, K., Takabe, Y., Amaral, F.E., Mohan, S., Wax, R., Corbin, K., Sanna-Cherchi, S., Mori, K., Johnson, L., Nickolas, T., D’Agati, V., Lin, C.S., Qiu, A., Al-Awqati, Q., Ratner, A.J. and Barasch, J.
Journal of Clinical Investigation 124 (7): 2963-2976. 1 July 2014

Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury.
Mori, K., Lee, H.T., Rapoport, D., Drexler, I.R., Foster, K., Yang, J., Schmidt-Ott, K.M., Chen, X., Li, J.Y., Weiss, S., Mishra, J., Cheema, F.H., Markowitz, G., Suganami, T., Sawai, K., Mukoyama, M., Kunis, C., D'Agati, V., Devarajan, P. and Barasch, J.
Journal of Clinical Investigation 115 (3): 610-621. March 2005

Journal of Dental Research

Porphyromonas gingivalis impairs oral epithelial barrier through targeting GRHL2.
Chen, W., Alshaikh, A., Kim, S., Kim, J., Chun, C., Mehrazarin, S., Lee, J., Lux, R., Kim, R.H., Shin, K.H., Park, N.H., Walentin, K., Schmidt-Ott, K.M. and Kang, M K
Journal of Dental Research 98 (10): 1150-1158. 1 September 2019

Human papillomavirus 16 E6 induces FoxM1B in oral keratinocytes through GRHL2.
Chen, W., Shimane, T., Kawano, S., Alshaikh, A., Kim, S.Y, Chung, S.H., Kim, R.H., Shin, K.H., Walentin, K., Park, N.H., Schmidt-Ott, K.M. and Kang, M.K.
Journal of Dental Research 97 (7): 795-802. 1 July 2018

Journal of Hypertension

MWF rats with spontaneous albuminuria inherit a reduced efficiency of nephron induction during early nephrogenesis in comparison to SHRs.
Schulte, L., Schulz, A., Unland, J., Schulz, H., Hubner, N., Schmidt-Ott, K.M. and Kreutz, R.
Journal of Hypertension 30 (10): 2031-2038. October 2012

Journal of Visualized Experiments

Nuclei isolation from adult mouse kidney for single-nucleus RNA-sequencing.
Leiz, J., Hinze, C., Boltengagen, A., Braeuning, C., Kocks, C., Rajewsky, N. and Schmidt-Ott, K.M.
Journal of Visualized Experiments (175): e62901. September 2021

Journal of the American College of Cardiology

Diagnostic and prognostic stratification in the emergency department using urinary biomarkers of nephron damage a multicenter prospective cohort study.
Nickolas, T.L., Schmidt-Ott, K.M., Canetta, P., Forster, C., Singer, E., Sise, M., Elger, A., Maarouf, O., Sola-Del Valle, D.A., O'Rourke, M., Sherman, E., Lee, P., Geara, A., Imus, P., Guddati, A., Polland, A., Rahman, W., Elitok, S., Malik, N., Giglio, J., El-Sayegh, S., Devarajan, P., Hebbar, S., Saggi, S.J., Hahn, B., Kettritz, R., Luft, F.C. and Barasch, J.
Journal of the American College of Cardiology 59 (3): 246-255. 17 January 2012

Journal of the American Society of Nephrology

Grainyhead-like 2 deficiency and kidney cyst growth in a mouse model.
Yurtdas, Z.Y., Kilic, E., Boor, P., Wyler, E., Landthaler, M., Jung, K. and Schmidt-Ott, K.M.
Journal of the American Society of Nephrology 35 (7): 838-853. July 2024

Kidney single-cell transcriptomes predict spatial corticomedullary gene expression and tissue osmolality gradients.
Hinze, C., Karaiskos, N., Boltengagen, A., Walentin, K., Redo, K., Himmerkus, N., Bleich, M., Potter, S.S., Potter, A.S., Eckardt, K.U., Kocks, C., Rajewsky, N. and Schmidt-Ott, K.M.
Journal of the American Society of Nephrology 32 (2): 291-306. February 2021

Mix for regeneration: nephron replacement by transplanted cells.
Schmidt-Ott, K.M.
Journal of the American Society of Nephrology 31 (12): 2743-2745. December 2020

Neutrophil gelatinase-associated lipocalin protects from ANCA-induced GN by inhibiting T(H)17 immunity.
Schreiber, A., Rousselle, A., Klocke, J., Bachmann, S., Popovic, S., Bontscho, J., Schmidt-Ott, K.M., Siffrin, V., Jerke, U., Ashraf, M.I., Panzer, U. and Kettritz, R.
Journal of the American Society of Nephrology 31 (7): 1569-1584. July 2020

Fluconazole increases osmotic water transport in renal collecting duct through effects on aquaporin-2 trafficking.
Vukićević, T., Hinze, C., Baltzer, S., Himmerkus, N., Quintanova, C., Zühlke, K., Compton, F., Ahlborn, R., Dema, A., Eichhorst, J., Wiesner, B., Bleich, M., Schmidt-Ott, K.M. and Klussmann, E.
Journal of the American Society of Nephrology 30 (5): 795-810. May 2019

GRHL2 is required for collecting duct epithelial barrier function and renal osmoregulation.
Hinze, C., Ruffert, J., Walentin, K., Himmerkus, N., Nikpey, E., Tenstad, O., Wiig, H., Mutig, K., Yurtdas, Z.Y., Klein, J.D., Sands, J.M., Branchi, F., Schumann, M., Bachmann, S., Bleich, M. and Schmidt-Ott, K.M.
Journal of the American Society of Nephrology 29 (3): 857-868. March 2018

Unique transcriptional programs identify subtypes of AKI.
Xu, K., Rosenstiel, P., Paragas, N., Hinze, C., Gao, X., Huai Shen, T., Werth, M., Forster, C., Deng, R., Bruck, E., Boles, R.W., Tornato, A., Gopal, T., Jones, M., Konig, Ju., Stauber, J., D'Agati, V., Erdjument-Bromage, H., Saggi, S., Wagener, G., Schmidt-Ott, K.M., Tatonetti, N., Tempst, P., Oliver, J.A., Guarnieri, P. and Barasch, J.
Journal of the American Society of Nephrology 28 (6): 1729-1740. June 2017

Tubular epithelial NF-κB activity regulates ischemic AKI.
Markó, L., Vigolo, E., Hinze, C., Park, J.K., Roël, G., Balogh, A., Choi, M., Wübken, A., Cording, J., Blasig, I.E., Luft, F.C., Scheidereit, C., Schmidt-Ott, K.M., Schmidt-Ullrich, R. and Müller, D.N.
Journal of the American Society of Nephrology 27 (9): 2658-2669. September 2016

A grainyhead-like 2/Ovo-like 2 pathway regulates renal epithelial barrier function and lumen expansion.
Aue, A., Hinze, C., Walentin, K., Ruffert, J., Yurtdas, Y., Werth, M., Chen, W., Rabien, A., Kilic, E., Schulzke, J.D., Schumann, M. and Schmidt-Ott, K.M.
Journal of the American Society of Nephrology 26 (11): 2704-2715. November 2015

Urinary NGAL marks cystic disease in HIV-associated nephropathy.
Paragas, N., Nickolas, T.L., Wyatt, C., Forster, C.S., Sise, M., Morgello, S., Jagla, B., Buchen, C., Stella, P., Sanna-Cherchi, S., Carnevali, M.L., Mattei, S., Bovino, A., Argentiero, L., Magnano, A., Devarajan, P., Schmidt-Ott, K.M., Allegri, L., Klotman, P., D'Agati, V., Gharavi, A.G. and Barasch, J.
Journal of the American Society of Nephrology 20 (8): 1687-1692. 1 August 2009

Dual action of neutrophil gelatinase-associated lipocalin.
Schmidt-Ott, K.M., Mori, K., Li, J.Y., Kalandadze, A., Cohen, D.J., Devarajan, P. and Barasch, J.
Journal of the American Society of Nephrology 18 (2): 407-413. February 2007

Novel regulators of kidney development from the tips of the ureteric bud.
Schmidt-Ott, K.M., Yang, J., Chen, X., Wang, H., Paragas, N., Mori, K., Li, J.Y., Lu, B., Costantini, F., Schiffer, M., Bottinger, E. and Barasch, J.
Journal of the American Society of Nephrology 16 (7): 1993-2002. July 2005

Kidney International

Strikingly conserved gene expression changes of polyamine regulating enzymes among various forms of acute and chronic kidney injury.
Sieckmann, T., Schley, G., Ögel, N., Kelterborn, S., Boivin, F.J., Fähling, M., Ashraf, M.I., Reichel, M., Vigolo, E., Hartner, A., Lichtenberger, F.B., Breiderhoff, T., Knauf, F., Rosenberger, C., Aigner, F., Schmidt-Ott, K., Scholz, H. and Kirschner, K.M.
Kidney International 104 (1): 90-107. July 2023

Urinary single-cell sequencing captures kidney injury and repair processes in human acute kidney injury.
Klocke, J., Kim, S.J., Skopnik, C.M., Hinze, C., Boltengagen, A., Metzke, D., Grothgar, E., Prskalo, L., Wagner, L., Freund, P., Görlich, N., Muench, F., Schmidt-Ott, K.M., Mashreghi, M.F., Kocks, C., Eckardt, K.U., Rajewsky, N. and Enghard, P.
Kidney International 102 (6): 1359-1370. December 2022

Acute kidney injury in patients receiving pembrolizumab combination therapy versus pembrolizumab monotherapy for advanced lung cancer.
Gupta, S., Strohbehn, I.A., Wang, Q., Hanna, P.E., Seethapathy, R., Prosek, J.M., Herrmann, S.M., Abudayyeh, A., Malik, A.B., Loew, S., Carlos, C.A., Chang, W.T., Beckerman, P., Mithani, Z., Shah, C.V., Renaghan, A., de Seigneux, S., Campedel, L., Kitchlu, A., Shin, D.S., Coppock, G., Lumlertgul, N., Garcia, P., Ortiz-Melo, D.I., Rashidi, A., Sprangers, B., Aggarwal, V., Benesova, K., Jhaveri, K.D., Cortazar, F.B., Weins, A., Zuo, Y., Mooradian, M.J., Reynolds, K.L., Leaf, D.E. and Sise, M.E.
Kidney International 102 (4): 930-935. October 2022

High rates of long-term renal recovery in survivors of coronavirus disease 2019-associated acute kidney injury requiring kidney replacement therapy.
Stockmann, H., Hardenberg, J.H.B., Aigner, A., Hinze, C., Gotthardt, I., Stier, B., Eckardt, K.U., Schmidt-Ott, K.M. and Enghard, P.
Kidney International 99 (4): 1021-1022. April 2021

Canonical BMP signaling in tubular cells mediates recovery after acute kidney injury.
Vigolo, E., Markó, L., Hinze, C., Müller, D.N., Schmidt-Ullrich, R. and Schmidt-Ott, K.M.
Kidney International 95 (1): 108-122. January 2019

The Ebf1 knockout mouse and glomerular maturation.
Schmidt-Ott, K.M.
Kidney International 85 (5): 1014-1016. May 2014

Urinary neutrophil gelatinase-associated lipocalin distinguishes pre-renal from intrinsic renal failure and predicts outcomes.
Singer, E., Elger, A., Elitok, S., Kettritz, R., Nickolas, T.L., Barasch, J., Luft, F.C. and Schmidt-Ott, K.M.
Kidney International 80 (4): 405-414. August 2011

WNT/beta-catenin signaling in polycystic kidney disease.
Wuebken, A. and Schmidt-Ott, K.M.
Kidney International 80 (2): 135-138. July 2011

ROCK inhibition facilitates tissue reconstitution from embryonic kidney cell suspensions.
Schmidt-Ott, K.M.
Kidney International 77 (5): 387-389. 1 March 2010

WNT/β-catenin signaling in nephron progenitors and their epithelial progeny.
Schmidt-Ott, K.M. and Barasch, J.
Kidney International 74 (8): 1004-1008. 2 October 2008

Unraveling the role of connective tissue growth factor in diabetic nephropathy.
Schmidt-Ott, K.M.
Kidney International 73 (4): 375-376. 2 February 2008

Nephrologists sans frontieres: the art and science of branching.
Schmidt-Ott, K.M.
Kidney International 69 (11): 1921-1923. 1 June 2006

Kidney International Reports

Critical illness and systemic inflammation are key risk factors of severe acute kidney injury in patients with COVID-19.
Hardenberg, J.H.B., Stockmann, H., Aigner, A., Gotthardt, I., Enghard, P., Hinze, C., Balzer, F., Schmidt, D., Zickler, D., Kruse, J., Körner, R., Stegemann, M., Schneider, T., Schumann, M., Müller-Redetzky, H., Angermair, S., Budde, K., Weber-Carstens, S., Witzenrath, M., Treskatsch, S., Siegmund, B., Spies, C., Suttorp, N., Rauch, G., Eckardt, K.U. and Schmidt-Ott, K.M.
Kidney International Reports 6 (4): 905-915. April 2021

Urinary NGAL-positive acute kidney injury and poor long-term Ootcomes in hospitalized patients.
Singer, E., Schrezenmeier, E.V., Elger, A., Seelow, E.R., Krannich, A., Luft, F.C. and Schmidt-Ott, K.M.
Kidney International Reports 1 (3): 114-124. September 2016

Lancet

Long-term effects of COVID-19 on kidney function.
Enghard, P., Hardenberg, J.H., Stockmann, H., Hinze, C., Eckardt, K.U. and Schmidt-Ott, K.M.
Lancet 397 (10287): 1806-1807. 15 May 2021

Mechanisms of Development

Vegf as an epithelial cell morphogen modulates branching morphogenesis of embryonic kidney by directly acting on the ureteric bud.
Marlier, A., Schmidt-Ott, K.M., Gallagher, A.R., Barasch, J. and Karihaloo, A.
Mechanisms of Development 126 (3-4): 91-98. March 2009

Medizinische Genetik

Technologies for profiling the impact of genomic variants on transcription factor binding.
Leiz, J., Rutkiewicz, M., Birchmeier, C., Heinemann, U. and Schmidt-Ott, K.M.
Medizinische Genetik 33 (2): 147-155. 14 August 2021

Medizinische Klinik, Intensivmedizin und Notfallmedizin

Hypo- und Hypernatriämien auf der Intensivstation : Fallstricke des Volumenmanagements [Hypo- and hypernatremia in the intensive care unit : pitfalls in volume management].
Schilling, J., Compton, F. and Schmidt-Ott, K.
Medizinische Klinik, Intensivmedizin und Notfallmedizin 116 : 672-677. November 2021

Methods

Vigilant vectors: adeno-associated virus with a biosensor to switch on amplified therapeutic genes in specific tissues in life-threatening diseases.
Tang, Y., Schmitt-Ott, K., Qian, K., Kagiyama, S. and Phillips, M.I.
Methods 28 (2): 259-266. October 2002

Nature Chemical Biology

Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex.
Bao, G., Clifton, M., Hoette, T.M., Mori, K., Deng, S.X., Qiu, A., Viltard, M., Williams, D., Paragas, N., Leete, T., Kulkarni, R., Li, X., Lee, B., Kalandadze, A., Ratner, A.J., Pizarro, J.C., Schmidt-Ott, K.M., Landry, D.W., Raymond, K.N., Strong, R.K. and Barasch, J.
Nature Chemical Biology 6 (8): 602-609. August 2010

Nature Genetics

Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis.
Lu, B.C., Cebrian, C., Chi, X., Kuure, S., Kuo, R., Bates, C.M., Arber, S., Hassell, J., Macneil, L., Hoshi, M., Jain, S., Asai, N., Takahashi, M., Schmidt-Ott, K.M., Barasch, J., D'Agati, V. and Costantini, F.
Nature Genetics 41 (12): 1295-1302. December 2009

Nature Medicine

The Ngal reporter mouse detects the response of the kidney to injury in real time.
Paragas, N., Qiu, A., Zhang, Q., Samstein, B., Deng, S.X., Schmidt-Ott, K.M., Viltard, M., Yu, W., Forster, C.S., Gong, G., Liu, Y., Kulkarni, R., Mori, K., Kalandadze, A., Ratner, A.J., Devarajan, P., Landry, D.W., D'Agati, V., Lin, C.S. and Barasch, J.
Nature Medicine 17 (2): 216-222. February 2011

Nature Reviews Nephrology

Kidney physiology and susceptibility to acute kidney injury: implications for renoprotection.
Scholz, H., Boivin, F.J., Schmidt-Ott, K.M., Bachmann, S., Eckardt, K.U., Scholl, U.I. and Persson, P.B.
Nature Reviews Nephrology 17 (5): 335-349. May 2021

Nephrologe

Aldosteronantagonisten "revisited" [Aldosterone antagonists revisited].
Swolinsky, J. and Schmidt-Ott, K.
Nephrologe 17 : 239-245. July 2022

Sollten Patienten nach überlebter akuter Nierenschädigung mit RAAS-Inhibitoren behandelt werden? [Should patients after surviving acute kidney injury be treated with RAAS inhibitors?].
Hoffmann, L. and Schmidt-Ott, K.M.
Nephrologe 16 (5): 305-306. September 2021

COVID-19 und akute Nierenschädigung im Intensivbereich [COVID-19 and acute kidney injury in the intensive care unit].
Hardenberg, J.H.B., Stockmann, H., Eckardt, K.U. and Schmidt-Ott, K.M.
Nephrologe 16 (1): 20-25. January 2021

Hyponatriämie in Notfall- und Intensivmedizin [Hyponatremia in emergency and critical care medicine].
Zickler, D. and Schmidt-Ott, K.M.
Nephrologe 14 (6): 422-430. November 2019

Nephrology Dialysis Transplantation

Plasma NGAL levels in stable kidney transplant recipients and the risk of allograft loss.
Swolinsky, J.S., Hinz, R.M., Markus, C.E., Singer, E., Bachmann, F., Halleck, F., Kron, S., Naik, M.G., Schmidt, D., Obermeier, M., Gebert, P., Rauch, G., Kropf, S., Haase, M., Budde, K., Eckardt, K.U., Westhoff, T.H. and Schmidt-Ott, K.M.
Nephrology Dialysis Transplantation 39 (3): 483-495. March 2024

Mutations in transcription factor CP2-like 1 may cause a novel syndrome with distal renal tubulopathy in humans.
Klämbt, V., Werth, M., Onuchic-Whitford, A.C., Getwan, M., Kitzler, T.M., Buerger, F., Mao, Y., Deutsch, K., Mann, N., Majmundar, A.J., Kaminski, M.M., Shen, Tian, Schmidt-Ott, K.M., Shalaby, M., El Desoky, S., Kari, J.A., Shril, S., Lienkamp, S.S., Barasch, J. and Hildebrandt, F.
Nephrology Dialysis Transplantation 36 (2): 237-246. February 2021

How to grow a kidney: patient-specific kidney organoids come of age.
Schmidt-Ott, K.M.
Nephrology Dialysis Transplantation 32 (1): 17-23. January 2017

Urine neutrophil gelatinase-associated lipocalin identifies unilateral and bilateral urinary tract obstruction.
Sise, M.E., Forster, C., Singer, E., Sola-Del Valle, D., Hahn, B., Schmidt-Ott, K.M., Barasch, J. and Nickolas, T.L.
Nephrology Dialysis Transplantation 26 (12): 4132-4135. December 2011

Neutrophil gelatinase-associated lipocalin as a biomarker of acute kidney injury--where do we stand today?
Schmidt-Ott, K.M.
Nephrology Dialysis Transplantation 26 (3): 762-764. March 2011

A renal biopsy yields sight as well as insight.
Wernicke, D., Schmidt-Ott, K., Brasen, J.H., Moeller, D.E. and Goebel, U.
Nephrology Dialysis Transplantation 18 (9): 1937-1938. September 2003

Nephron Physiology

Dissecting stages of mesenchymal-to-epithelial conversion during kidney development.
Schmidt-Ott, K.M., Lan, D., Hirsh, B.J. and Barasch, J.
Nephron Physiology 104 (1): 56-60. August 2006

News in Physiological Sciences

The Discovery of Renin 100 Years Ago.
Phillips, M.I. and Schmidt-Ott, K.M.
News in Physiological Sciences 14 (6): 271-274. December 1999

Nucleic Acids Research

Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.
Ming, Q., Roske, Y., Schuetz, A., Walentin, K., Ibraimi, I., Schmidt-Ott, K.M. and Heinemann, U.
Nucleic Acids Research 46 (4): 2082-2095. 28 February 2018

Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction.
Schmidt, F., Gasparoni, N., Gasparoni, G., Gianmoena, K., Cadenas, C., Polansky, J.K., Ebert, P., Nordstroem, K., Barann, M., Sinha, A., Froehler, S., Xiong, J., Dehghani Amirabad, A., Behjati Ardakani, F., Hutter, B., Zipprich, G., Felder, B., Eils, J., Brors, B., Chen, W., Hengstler, J.G., Hamann, A., Lengauer, T., Rosenstiel, P., Walter, J. and Schulz, M.H.
Nucleic Acids Research 45 (1): 54-66. 9 January 2017

Oncogenesis

Grainyhead-like 2 (GRHL2) knockout abolishes oral cancer development through reciprocal regulation of the MAP kinase and TGF-β signaling pathways.
Chen, W., Kang, K.L., Alshaikh, A., Varma, S., Lin, Y.L., Shin, K.H., Kim, R., Wang, C.Y., Park, N.H., Walentin, K., Schmidt-Ott, K.M. and Kang, M.K.
Oncogenesis 7 (5): 38. 8 May 2018

PLoS ONE

Does NGAL reduce costs? A cost analysis of urine NGAL (uNGAL) & serum creatinine (sCr) for acute kidney injury (AKI) diagnosis.
Parikh, A., Rizzo, J.A, Canetta, P., Forster, C., Sise, M., Maarouf, O., Singer, E., Elger, A., Elitok, S., Schmidt-Ott, K., Barasch, J. and Nickolas, T.L
PLoS ONE 12 (5): e0178091. 19 May 2017

Stromal protein Ecm1 regulates ureteric bud patterning and branching.
Paroly, S.S., Wang, F., Spraggon, L., Merregaert, J., Batourina, E., Tycko, B., Schmidt-Ott, K.M., Grimmond, S., Little, M. and Mendelsohn, C.
PLoS ONE 8 (12): e84155. 31 December 2013

Emotional voice processing: investigating the role of genetic variation in the serotonin transporter across development.
Grossmann, T., Vaish, A., Franz, J., Schroeder, R., Stoneking, M. and Friederici, A.D.
PLoS ONE 8 (7): e68377. 8 July 2013

Pediatric Nephrology

Functional roles of Grainyhead-like transcription factors in renal development and disease.
Boivin, F.J. and Schmidt-Ott, K.M.
Pediatric Nephrology 35 (2): 181-190. February 2020

Proceedings of the National Academy of Sciences of the United States of America

A Mendelian locus on chromosome 16 determines susceptibility to doxorubicin nephropathy in the mouse.
Zheng, Z., Schmidt-Ott, K.M., Chua, S., Foster, K.A., Frankel, R.Z., Pavlidis, P., Barasch, J., D'Agati, V.D. and Gharavi, A.G.
Proceedings of the National Academy of Sciences of the United States of America 102 (7): 2502-2507. 15 February 2005

Regulatory Peptides

The multiple actions of angiotensin II in atherosclerosis.
Schmidt-Ott, K.M., Kagiyama, S. and Phillips, M.I.
Regulatory Peptides 93 (1-3): 65-77. 25 September 2000

Scientific Reports

Transient receptor potential vanilloid 4 channel deficiency aggravates tubular damage after acute renal ischaemia reperfusion.
Mannaa, M., Markó, L., Balogh, A., Vigolo, E., N'diaye, G., Kaßmann, M., Michalick, L., Weichelt, U., Schmidt-Ott, K.M., Liedtke, W.B., Huang, Y., Müller, D.N., Kuebler, W.M. and Gollasch, M.
Scientific Reports 8 (1): 4878. 20 March 2018

Stem Cells

Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes.
Metsuyanim, S., Pode-Shakked, N., Schmidt-Ott, K.M., Keshet, G., Rechavi, G., Blumental, D. and Dekel, B.
Stem Cells 26 (7): 1808-1817. July 2008

Wiener klinisches Magazin

Hypo- und Hypernatriämien auf der Intensivstation : Fallstricke des Volumenmanagements [Hypo- and hypernatremia in the intensive care unit : pitfalls in volume management].
Schilling, J., Compton, F. and Schmidt-Ott, K.
Wiener klinisches Magazin 25 : 32-37. 10 January 2022

eLife

The centrosomal protein 83 (CEP83) regulates human pluripotent stem cell differentiation towards the kidney lineage.
Mansour, F., Hinze, C., Telugu, N.S., Kresoja, J., Shaheed, I.B., Mosimann, C., Diecke, S. and Schmidt-Ott, K.M.
eLife 11 : e80165. 12 October 2022

Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts.
Werth, M., Schmidt-Ott, K.M., Leete, T., Qiu, A., Hinze, C., Viltard, M., Paragas, N., Shawber, C.J., Yu, W., Lee, P., Chen, X., Sarkar, A., Mu, W., Rittenberg, A., Lin, C.S., Kitajewski, J., Al-Awqati, Q. and Barasch, J.
eLife 6 : e24265. 3 June 2017

medRxiv

Disease overarching mechanisms that explain and predict outcome of patients with high cardiovascular risk: rationale and design of the Berlin Long-term Observation of vascular events (BeLOVE) study.
Siegerink, B., Weber, J., Ahmadi, M., Eckardt, K.U., Edelmann, F., Endres, M., Gerhardt, H., Haubold, K., Hübner, N., Landmesser, U., Leistner, D., Mai, K., Müller, D.N., Pieske, B., Rauch, G., Schmidt, S., Schmidt-Ott, K., Schulz-Menger, J., Spranger, J. and Pischon, T.
medRxiv : 19001024. 15 July 2019