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Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis

Item Type:Article
Title:Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis
Creators Name:Lu, B.C., Cebrian, C., Chi, X., Kuure, S., Kuo, R., Bates, C.M., Arber, S., Hassell, J., Macneil, L., Hoshi, M., Jain, S., Asai, N., Takahashi, M., Schmidt-Ott, K.M., Barasch, J., D'Agati, V. and Costantini, F.
Abstract:Glial cell line-derived neurotrophic factor signaling through the Ret receptor tyrosine kinase is crucial for ureteric bud branching morphogenesis during kidney development, yet few of the downstream genes are known. Here we show that the ETS transcription factors Etv4 and Etv5 are positively regulated by Ret signaling in the ureteric bud tips. Mice lacking both Etv4 alleles and one Etv5 allele show either renal agenesis or severe hypodysplasia, whereas kidney development fails completely in double homozygotes. We identified several genes whose expression in the ureteric bud depends on Etv4 and Etv5, including Cxcr4, Myb, Met and Mmp14. Thus, Etv4 and Etv5 are key components of a gene network downstream of Ret that promotes and controls renal branching morphogenesis.
Keywords:DNA-Binding Proteins, Glial Cell Line-Derived Neurotrophic Factor, Kidney, Morphogenesis, Proto-Oncogene Proteins c-ets, Proto-Oncogene Proteins c-ret, Transcription Factors, Animals, Mice
Source:Nature Genetics
Publisher:Nature Publishing Group
Page Range:1295-1302
Date:December 2009
Additional Information:Erratum in: Nature Genetics 42, 361 (2010) | doi:10.1038/ng0410-361d
Official Publication:https://doi.org/10.1038/ng.476
PubMed:View item in PubMed

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