Browse by Research Team

Blood

Macrophage development from hematopoietic stem cells requires PU.1 coordinated microRNA expression.
Ghani, S., Riemke, P., Schoenheit, J., Lenze, D., Stumm, J., Hoogenkamp, M., Lagendijk, A., Heinz, S., Bonifer, C., Bakkers, J., Abdelilah-Seyfried, S., Hummel, M. and Rosenbauer, F.
Blood 118 (8): 2275-2284. 25 August 2011

Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells.
Leddin, M., Perrod, C., Hoogenkamp, M., Ghani, S., Assi, S., Heinz, S., Wilson, N.K., Follows, G., Schoenheit, J., Vockentanz, L., Mosamam, A., Chen, W., Tenen, D.G., Westhead, D.R., Goettgens, B., Bonifer, C. and Rosenbauer, F.
Blood 117 (10): 2827-2838. 10 March 2011

Effect of transcription-factor concentrations on leukemic stem cells.
Rosenbauer, F., Koschmieder, S., Steidl, U. and Tenen, D.G.
Blood 106 : 1519-1524. 1 September 2005

pDP4, a novel glycoprotein secreted by mature granulocytes, is regulated by transcription factor PU.1.
Rosenbauer, F., Wagner, K., Zhang, P., Knobeloch, K.P., Iwama, A. and Tenen, D.G.
Blood 103 : 4294-4301. 1 June 2004

Cell Cycle

Uncovering a unique role for DNA methylation in hematopoietic and leukemic stem cells.
Vockentanz, L., Broeske, A.M. and Rosenbauer, F.
Cell Cycle 9 (4): 640-641. February 2010

Cell Reports

PU.1 level-directed chromatin structure remodeling at the Irf8 gene drives dendritic cell commitment.
Schönheit, J., Kuhl, C., Gebhardt, M.L., Klett, F.F., Riemke, P., Scheller, M., Huang, G., Naumann, R., Leutz, A., Stocking, C., Priller, J., Andrade-Navarro, M.A. and Rosenbauer, F.
Cell Reports 3 (5): 1617-1628. 30 May 2013

Development

The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex.
Werth, M., Walentin, K., Aue, A., Schoenheit, J., Wuebken, A., Pode-Shakked, N., Vilianovitch, L., Erdmann, B., Dekel, B., Bader, M., Barasch, J., Rosenbauer, F., Luft, F.C. and Schmidt-Ott, K.M.
Development 137 (22): 3835-3845. November 2010

EMBO Journal

The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation.
Feinberg, M.W., Wara, A.K., Cao, Z., Lebedeva, M.A., Rosenbauer, F., Iwasaki, H., Hirai, H., Katz, J.P., Haspel, R., Gray, S., Akashi, K., Segre, J., Kaestner, K.H., Tenen, D.G. and Jain, M.K.
EMBO Journal 26 (18): 4138-4148. 19 September 2007

Genes & Development

PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element.
Ebralidze, A.K., Guibal, F.C., Steidl, U., Zhang, P., Lee, S., Bartholdy, B., Jorda, M.A., Petkova, V., Rosenbauer, F., Huang, G., Dayaram, T., Klupp, J., O'Brien, K.B., Will, B., Hoogenkamp, M., Borden, K.L., Bonifer, C. and Tenen, D.G.
Genes & Development 22 (15): 2085-2092. 1 August 2008

International Journal of Hematology

Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia.
Koschmieder, S., Rosenbauer, F., Steidl, U., Owens, B.M. and Tenen, D.G.
International Journal of Hematology 81 : 368-377. 1 June 2005

Journal of Clinical Investigation

A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.
Steidl, U., Steidl, C., Ebralidze, A., Chapuy, B., Han, H.J., Will, B., Rosenbauer, F., Becker, A., Wagner, K., Koschmieder, S., Kobayashi, S., Costa, D.B., Schulz, T., OBrien, K.B., Verhaak, R.G.W., Delwel, R., Haase, D., Truemper, L., Krauter, J., Kohwi-Shigematsu, T., Griesinger, F. and Tenen, D.G.
Journal of Clinical Investigation 117 (9): 2611-2620. 4 September 2007

Molecular Cell

Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells.
Staber, P.B., Zhang, P., Ye, M., Welner, R.S., Nombela-Arrieta, C., Bach, C., Kerenyi, M., Bartholdy, B.A., Zhang, H., Alberich-Jorda, M., Lee, S., Yang, H., Ng, F., Zhang, J., Leddin, M., Silberstein, L.E., Hoefler, G., Orkin, S.H., Goettgens, B., Rosenbauer, F., Huang, G. and Tenen, D.G.
Molecular Cell 49 (5): 934-946. 7 March 2013

Molecular and Cellular Biology

Potential autoregulation of transcription factor PU.1 by an upstream regulatory element.
Okuno, Y., Huang, G., Rosenbauer, F., Evans, E.K., Radomska, H.S., Iwasaki, H., Akashi, K., Moreau-Gachelin, F., Li, Y., Zhang, P., Goettgens, B. and Tenen, D.G.
Molecular and Cellular Biology 25 : 2832-2845. 1 April 2005

Nature Genetics

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.
Broeske, A.M., Vockentanz, L., Kharazi, S., Huska, M.R., Mancini, E., Scheller, M., Kuhl, C., Enns, A., Prinz, M., Jaenisch, R., Nerlov, C., Leutz, A., Andrade-Navarro, M.A., Jacobsen, S.E. and Rosenbauer, F.
Nature Genetics 41 (11): 1207-1215. November 2009

Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells.
Steidl, U., Rosenbauer, F., Verhaak, R.G.W., Gu, X., Ebralidze, A., Otu, H.H., Klippel, S., Steidl, C., Bruns, I., Costa, D.B., Wagner, K., Aivado, M., Kobbe, G., Valk, P.J.M., Passegue, E., Libermann, T.A., Delwel, R. and Tenen, D.G.
Nature Genetics 38 (11): 1269-1277. November 2006

Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1.
Rosenbauer, F., Owens, B.M., Yu, L., Tumang, J.R., Steidl, U., Kutok, J.L., Clayton, L.K., Wagner, K., Scheller, M., Iwasaki, H., Liu, C., Hackanson, B., Akashi, K., Leutz, A., Rothstein, T.L., Plass, C. and Tenen, D.G.
Nature Genetics 38 (1): 27-37. January 2006

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.
Rosenbauer, F., Wagner, K., Kutok, J.L., Iwasaki, H., Le Beau, M.M., Okuno, Y., Akashi, K., Fiering, S. and Tenen, D.G.
Nature Genetics 36 : 624-630. 1 June 2004

Nature Immunology

Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils.
Fischer, J., Walter, C., Tönges, A., Aleth, H., Costa Jordão, M.J., Leddin, M., Gröning, V., Erdmann, T., Lenz, G., Roth, J., Vogl, T., Prinz, M., Dugas, M., Jacobsen, I.D. and Rosenbauer, F.
Nature Immunology 20 (5): 546-558. May 2019

Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation.
Scheller, M., Huelsken, J., Rosenbauer, F., Taketo, M.M., Birchmeier, W., Tenen, D.G. and Leutz, A.
Nature Immunology 7 (10): 1037-1047. October 2006

Nature Reviews Immunology

Transcription factors in myeloid development: balancing differentiation with transformation.
Rosenbauer, F. and Tenen, D.G.
Nature Reviews Immunology 7 (2): 105-117. February 2007

Proceedings of the National Academy of Sciences of the United States of America

Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy.
Wagner, K., Zhang, P., Rosenbauer, F., Drescher, B., Kobayashi, S., Radomska, H.S., Kutok, J.L., Gilliland, D.G., Krauter, J. and Tenen, D.G.
Proceedings of the National Academy of Sciences of the United States of America 103 (16): 6338-6343. 18 April 2006