Browse by Research Team

2023

CAR links hypoxia signaling to improved survival after myocardial infarction.
Freiberg, F., Thakkar, M., Hamann, W., Lopez Carballo, J., Jüttner, R., Voss, F.K., Becher, P.M., Westermann, D., Tschöpe, C., Heuser, A., Rocks, O., Fischer, R. and Gotthardt, M.
Experimental and Molecular Medicine 55 (3): 643-652. March 2023

2020

Morphine alleviates pain after heart cryoinjury in zebrafish without impeding regeneration.
Lelek, S., Simões, M., Hu, B., Alameldeen, A.M.A., Czajkowski, M.T., Meyer, A.M., Ferrara, F., Junker, J.P. and Panáková, D.
bioRxiv : 2020.10.01.322560. 2 October 2020

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.
Müller, P.M., Rademacher, J., Bagshaw, R.D., Wortmann, C., Barth, C., van Unen, J., Alp, K.M., Giudice, G., Eccles, R.L., Heinrich, L.E., Pascual-Vargas, P., Sanchez-Castro, M., Brandenburg, L., Mbamalu, G., Tucholska, M., Spatt, L., Czajkowski, M.T., Welke, R.W., Zhang, S., Nguyen, V., Rrustemi, T., Trnka, P., Freitag, K., Larsen, B., Popp, O., Mertins, P., Gingras, A.C., Roth, F.P., Colwill, K., Bakal, C., Pertz, O., Pawson, T., Petsalaki, E. and Rocks, O.
Nature Cell Biology 22 (4): 498-511. April 2020

2018

Interaction modulation through arrays of clustered methyl-arginine protein modifications.
Woodsmith, J., Casado-Medrano, V., Benlasfer, N., Eccles, R.L., Hutten, S., Heine, C.L., Thormann, V., Abou-Ajram, C., Rocks, O., Dormann, D. and Stelzl, U.
Life Science Alliance 1 (5): e201800178. October 2018

Cumulative regulatory potential of clustered methyl-arginine protein modifications.
Woodsmith, J., Casado-Medrano, V., Benlasfer, N., Eccles, R.L., Hutten, S., Heine, C., Thormann, V., Abou-Ajram, C., Rocks, O., Dormann, D. and Stelzl, U.
bioRxiv : 289041. 26 March 2018

An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.
Schrade, K., Tröger, J., Eldahshan, A., Zühlke, K., Abdul Azeez, K.R., Elkins, J.M., Neuenschwander, M., Oder, A., Elkewedi, M.M.H., Jaksch, S., Andrae, K., Li, J., Fernandes, J., Müller, P.M., Grunwald, S., Marino, S.F., Vukićević, T., Eichhorst, J., Wiesner, B., Weber, M., Kapiloff, M., Rocks, O., Daumke, O., Wieland, T., Knapp, S., von Kries, J.P. and Klussmann, E.
PLoS ONE 13 (1): e0191423. 26 January 2018

2017

Quantitative GTPase affinity purification identifies Rho family protein interaction partners.
Paul, F., Zauber, H., von Berg, L., Rocks, O., Daumke, O. and Selbach, M.
Molecular & Cellular Proteomics 16 (1): 73-85. 1 January 2017

2016

Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.
Arumughan, A., Roske, Y., Barth, C., Lleras Forero, L., Bravo-Rodriguez, K., Redel, Al., Kostova, S., McShane, E., Opitz, R., Faelber, K., Rau, K., Mielke, T., Daumke, O., Selbach, M., Sanchez-Garcia, E., Rocks, O., Panáková, D., Heinemann, U. and Wanker, E.E.
Nature Communications 7 : 13047. 20 October 2016

Bimodal antagonism of PKA signalling by ARHGAP36.
Eccles, R.L., Czajkowski, M.T., Barth, C., Müller, P.M., McShane, E., Grunwald, S., Beaudette, P., Mecklenburg, N., Volkmer, R., Zühlke, K., Dittmar, G., Selbach, M., Hammes, A., Daumke, O., Klussmann, E., Urbé, S. and Rocks, O.
Nature Communications 7 : 12963. 7 October 2016

The anticancer phytochemical rocaglamide inhibits Rho GTPase activity and cancer cell migration.
Becker, M.S., Müller, P.M., Bajorat, J., Schroeder, A., Giaisi, M., Amin, E., Ahmadian, M.R., Rocks, O., Köhler, R., Krammer, P.H. and Li-Weber, M.
Oncotarget 7 (32): 51908-51921. 9 August 2016

A new role of the Rac-GAP β2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression.
Casado-Medrano, V., Barrio-Real, L., García-Rostán, G., Baumann, M., Rocks, O. and Caloca, M.J.
Oncotarget 7 (19): 28301-28319. 10 May 2016

2014

Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP.
Gray, E.J., Petsalaki, E., James, D.A., Bagshaw, R.D., Stacey, M.M., Rocks, O., Gingras, A.C. and Pawson, T.
Journal of Biological Chemistry 289 (51): 35397-35408. 19 December 2014

2013

Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein.
Fröhlich, C., Grabiger, S., Schwefel, D., Faelber, K., Rosenbaum, E., Mears, J., Rocks, O. and Daumke, O.
EMBO Journal 32 (9): 1280-1292. 2 May 2013

Structural insights into the mechanism of GTPase activation in the GIMAP family.
Schwefel, D., Arasu, B.S., Marino, S.F., Lamprecht, B., Köchert, K., Rosenbaum, E., Eichhorst, J., Wiesner, B., Behlke, J., Rocks, O., Mathas, S. and Daumke, O.
Structure 21 (4): 550-559. 2 April 2013

2011

A roadmap to generate renewable protein binders to the human proteome.
Colwill, K. and Graeslund, S.
Nature Methods 8 (7): 551-558. 15 May 2011

2010

Regulation of Ras localization by acylation enables a mode of intracellular signal propagation.
Lorentzen, A., Kinkhabwala, A., Rocks, O., Vartak, N. and Bastiaens, P.I.
Science Signaling 3 (140): ra68. 21 September 2010

Small-molecule inhibition of APT1 affects Ras localization and signaling.
Dekker, F.J., Rocks, O., Vartak, N., Menninger, S., Hedberg, C., Balamurugan, R., Wetzel, S., Renner, S., Gerauer, M., Schoelermann, B., Rusch, M., Kramer, J.W., Rauh, D., Coates, G.W., Brunsveld, L., Bastiaens, P.I. and Waldmann, H.
Nature Chemical Biology 6 (6): 449-456. June 2010

The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins.
Rocks, O., Gerauer, M., Vartak, N., Koch, S., Huang, Z.P., Pechlivanis, M., Kuhlmann, J., Brunsveld, L., Chandra, A., Ellinger, B., Waldmann, H. and Bastiaens, P.I.
Cell 141 (3): 458-471. 30 April 2010

2006

An experimental setup for frequency domain FLIM.
Verveer, P.J., Rocks, O., Harpur, A.G. and Bastiaens, P.I.H.
Cold Spring Harbor Protocols 2006 (6) 1 November 2006

FLIM measurements and frequency domain FLIM data analysis.
Verveer, P.J., Rocks, O., Harpur, A.G. and Bastiaens, P.I.H.
Cold Spring Harbor Protocols 2006 (6) 1 November 2006

Imaging protein interactions by FRET microscopy: FLIM measurements.
Verveer, P.J., Rocks, O., Harpur, A.G. and Bastiaens, P.I.H.
Cold Spring Harbor Protocols 2006 (6) 1 November 2006

Imaging protein interactions by FRET microscopy: FRET measurements by acceptor photobleaching.
Verveer, P.J., Rocks, O., Harpur, A.G. and Bastiaens, P.I.H.
Cold Spring Harbor Protocols 2006 (6) 1 November 2006

Imaging protein interactions by FRET microscopy: FRET measurements by sensitized emission.
Verveer, P.J., Rocks, O., Harpur, A.G. and Bastiaens, P.I.H.
Cold Spring Harbor Protocols 2006 (6) 1 November 2006

Imaging protein interactions by FRET microscopy: cell preparation for FRET analysis.
Verveer, P.J., Rocks, O., Harpur, A.G. and Bastiaens, P.I.H.
Cold Spring Harbor Protocols 2006 (6) 1 November 2006

Imaging protein interactions by FRET microscopy: labeling proteins with fluorescent dyes.
Verveer, P.J., Rocks, O., Harpur, A.G. and Bastiaens, P.I.H.
Cold Spring Harbor Protocols 2006 (6) 1 November 2006

Measuring FRET by acceptor photobleaching.
Verveer, P.J., Rocks, O., Harpur, A.G. and Bastiaens, P.I.H.
Cold Spring Harbor Protocols 2006 (6) 1 November 2006

Measuring FRET by sensitized emission.
Verveer, P.J., Rocks, O., Harpur, A.G. and Bastiaens, P.I.H.
Cold Spring Harbor Protocols 2006 (6) 1 November 2006

Spatio-temporal segregation of Ras signals: one ship, three anchors, many harbors.
Rocks, O., Peyker, A. and Bastiaens, P.I.
Current Opinion in Cell Biology 18 (4): 351-357. August 2006

2005

An acylation cycle regulates localization and activity of palmitoylated Ras isoforms.
Rocks, O., Peyker, A., Kahms, M., Verveer, P.J., Koerner, C., Lumbierres, M., Kuhlmann, J., Waldmann, H., Wittinghofer, A. and Bastiaens, P.I.
Science 307 (5716): 1746-1752. 18 March 2005

Imaging activation of two Ras isoforms simultaneously in a single cell.
Peyker, A., Rocks, O. and Bastiaens, P.I.
ChemBioChem 6 (1): 78-85. January 2005

2004

Red-edge anisotropy microscopy enables dynamic imaging of homo-FRET between green fluorescent proteins in cells.
Squire, A., Verveer, P.J., Rocks, O. and Bastiaens, P.I.
Journal of Structural Biology 147 (1): 62-69. July 2004

2003

EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation.
Reynolds, A.R., Tischer, C., Verveer, P.J., Rocks, O. and Bastiaens, P.I.
Nature Cell Biology 5 (5): 447-453. May 2003

2002

Structural domains required for channel function of the mouse transient receptor potential protein homologue TRP1beta.
Engelke, M., Friedrich, O., Budde, P., Schaefer, C., Niemann, U., Zitt, C., Juengling, E., Rocks, O., Lueckhoff, A. and Frey, J.
FEBS Letters 523 (1-3): 193-199. 17 July 2002

1999

Adenine nucleotide translocase-1, a component of the permeability transition pore, can dominantly induce apoptosis.
Bauer, M.K.A., Schubert, A., Rocks, O. and Grimm, S.
Journal of Cell Biology 147 (7): 1493-1502. 27 December 1999