Browse by Research Team

2024

CXCR4 has a dual role in improving the efficacy of BCMA redirected CAR-NK cells in multiple myeloma.
Moles, M.W., Erdlei, H., Menzel, L., Massaro, M., Fiori, A., Bunse, M., Schrimpf, M., Gerlach, K., Gudipati, V., Reiser, J., Mathavan, K., Goodrich, J., Huppa, J.B., Kroenke, J., Valamehr, B., Höpken, U.E. and Rehm, A.
Frontiers in Immunology 15 : 1383136. 24 June 2024

In vitro functionality and endurance of GMP-compliant point-of-care BCMA.CAR-T cells at different timepoints of cryopreservation.
Jiang, G., Neuber, B., Hückelhoven-Krauss, A., Höpken, U., Ding, Y., Sedloev, D., Wang, L., Reichman, A., Eberhardt, F., Wermke, M., Rehm, A., Müller-Tidow, C., Schmitt, A. and Schmitt, M.
International Journal of Molecular Sciences 25 (3): 1394. 23 January 2024

2022

Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma.
Cichocki, F., Bjordahl, R., Goodridge, J.P., Mahmood, S., Gaidarova, S., Abujarour, R., Davis, Z.B., Merino, A., Tuininga, K., Wang, H., Kumar, A., Groff, B., Witty, A., Bonello, G., Huffman, J., Dailey, T., Lee, T.T., Malmberg, K.J., Walcheck, B., Höpken, U., Rehm, A., Valamehr, B. and Miller, J.S.
Nature Communications 13 (1): 7341. 29 November 2022

EBAG9-silencing exerts an immune checkpoint function without aggravating adverse effects.
Wirges, A., Bunse, M., Joedicke, J.J., Blanc, E., Gudipati, V., Moles, M.W., Shiku, H., Beule, D., Huppa, J.B., Höpken, U.E. and Rehm, A.
Molecular Therapy 30 (11): 3358-3378. 2 November 2022

CXCR4 mediates leukemic cell migration and survival in the testicular microenvironment.
Skroblyn, T., Joedicke, J.J., Pfau, M., Krüger, K., Bourquin, J.P., Izraeli, S., Eckert, C. and Höpken, U.E.
Journal of Pathology 258 (1): 12-25. September 2022

Analyses of murine lymph node endothelial cell subsets using single-cell RNA sequencing and spectral flow cytometry.
Menzel, L., Zschummel, M. and Rehm, A.
STAR Protocols 3 (2): 101267. 17 June 2022

Pharmacological interventions enhance virus-free generation of TRAC-replaced CAR T cells.
Kath, J., Du, W., Pruene, A., Braun, T., Thommandru, B., Turk, R., Sturgeon, M.L., Kurgan, G.L., Amini, L., Stein, M., Zittel, T., Martini, S., Ostendorf, L., Wilhelm, A., Akyüz, L., Rehm, A., Hoepken, U.E., Pruß, A., Künkele, A., Jacobi, A.M., Volk, H.D., Schmueck-Henneresse, M., Stripecke, R., Reinke, P. and Wagner, D.L.
Molecular Therapy - Methods and Clinical Development 25 : 311-330. 9 June 2022

EBAG9 controls CD8(+) T cell memory formation responding to tumor challenge in mice.
Rehm, A., Wirges, A., Hoser, D., Fischer, C., Herda, S., Gerlach, K., Sauer, S., Willimsky, G. and Hoepken, U.E.
JCI Insight 7 (11): e155534. 8 June 2022

A Notch/STAT3-driven Blimp-1/c-Maf-dependent molecular switch induces IL-10 expression in human CD4(+) T cells and is defective in Crohn's disease patients.
Ahlers, J., Mantei, A., Lozza, L., Stäber, M., Heinrich, F., Bacher, P., Hohnstein, T., Menzel, L., Yüz, S.G., Alvarez-Simon, D., Bickenbach, A.R., Weidinger, C., Mockel-Tenbrinck, N., Kühl, A.A., Siegmund, B., Maul, J., Neumann, C. and Scheffold, A.
Mucosal Immunology 15 (3): 480-490. May 2022

Accelerating clinical scale production of BCMA CAR T cells with defined maturation stages.
Joedicke, J.J., Großkinsky, U., Gerlach, K., Künkele, A., Höpken, U.E. and Rehm, A.
Molecular Therapy - Methods and Clinical Development 24 : 181-198. 10 March 2022

Comparison of FACS and PCR for detection of BCMA-CAR-T cells.
Reichman, A., Kunz, A., Joedicke, J.J., Höpken, U.E., Keib, A., Neuber, B., Sedloev, D., Wang, L., Jiang, G., Hückelhoven-Krauss, A., Eberhardt, F., Müller-Tidow, C., Wermke, M., Rehm, A., Schmitt, M. and Schmitt, A.
International Journal of Molecular Sciences 23 (2): 903. 14 January 2022

2021

Lymphocyte access to lymphoma is impaired by high endothelial venule regression.
Menzel, L., Zschummel, M., Crowley, T., Franke, V., Grau, M., Ulbricht, C., Hauser, A., Siffrin, V., Bajénoff, M., Acton, S.E., Akalin, A., Lenz, G., Willimsky, G., Höpken, U.E. and Rehm, A.
Cell Reports 37 (4): 109878. 26 October 2021

MACC1 regulates clathrin-mediated endocytosis and receptor recycling of transferrin receptor and EGFR in colorectal cancer.
Imbastari, F., Dahlmann, M., Sporbert, A., Ciolli Mattioli, C., Mari, T., Scholz, F., Timm, L., Twamley, S., Migotti, R., Walther, W., Dittmar, G., Rehm, A. and Stein, U.
Cellular and Molecular Life Sciences 78 (7): 3525-3542. April 2021

CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells.
Bunse, M., Pfeilschifter, J., Bluhm, J., Zschummel, M., Joedicke, J.J., Wirges, A., Stark, H., Kretschmer, V., Chmielewski, M., Uckert, W., Abken, H., Westermann, J., Rehm, A. and Höpken, U.E.
Nature Communications 12 (1): 240. 11 January 2021

2020

Angiogenesis in lymph nodes is a critical regulator of immune response and lymphoma growth.
Menzel, L., Höpken, U.E. and Rehm, A.
Frontiers in Immunology 11 : 591741. 3 December 2020

The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.
Scholz, F., Grau, M., Menzel, L., Graband, A., Zapukhlyak, M., Leutz, A., Janz, M., Lenz, G., Rehm, A. and Höpken, U.E.
Proceedings of the National Academy of Sciences of the United States of America 117 (42): 26328-26339. 20 October 2020

Lymphoma angiogenesis is orchestrated by noncanonical signaling pathways.
Gloger, M., Menzel, L., Grau, M., Vion, A.C., Anagnostopoulos, I., Zapukhlyak, M., Gerlach, K., Kammertöns, T., Hehlgans, T., Zschummel, M., Lenz, G., Gerhardt, H., Höpken, U.E. and Rehm, A.
Cancer Research 80 (6): 1316-1329. March 2020

2019

Targeting the tumor microenvironment of leukemia and lymphoma.
Höpken, U.E. and Rehm, A.
Trends in Cancer 5 (6): 351-364. June 2019

2018

CAR T cells with enhanced sensitivity to B cell maturation antigen for the targeting of B cell non-Hodgkin's lymphoma and multiple myeloma.
Bluhm, J., Kieback, E., Marino, S.F., Oden, F., Westermann, J., Chmielewski, M., Abken, H., Uckert, W., Höpken, U.E. and Rehm, A.
Molecular Therapy 26 (8): 1906-1920. 1 August 2018

2017

The splenic marginal zone shapes the phenotype of leukemia B cells and facilitates their niche-specific retention and survival.
Stache, V., Verlaat, L., Gätjen, M., Heinig, K., Westermann, J., Rehm, A. and Höpken, U.E.
OncoImmunology 6 (6): e1323155. 6 June 2017

Rapid eradication of colon carcinoma by Clostridium perfringens Enterotoxin suicidal gene therapy.
Pahle, J., Menzel, L., Niesler, N., Kobelt, D., Aumann, J., Rivera, M. and Walther, W.
BMC Cancer 17 (1): 129. 13 February 2017

2016

Splenic marginal zone granulocytes acquire an accentuated neutrophil B cell-helper phenotype in chronic lymphocytic leukemia.
Gätjen, M., Brand, F., Grau, M., Gerlach, K., Kettritz, R., Westermann, J., Anagnostopoulos, I., Lenz, P., Lenz, G., Höpken, U.E. and Rehm, A.
Cancer Research 76 (18): 5253-5265. 15 September 2016

Dysregulated development of IL-17-and IL-21-expressing follicular helper T cells and increased germinal center formation in the absence of RORγt.
Wichner, K., Stauss, D., Kampfrath, B., Krüger, K., Müller, G., Rehm, A., Lipp, M. and Höpken, U.E.
FASEB Journal 30 (2): 761-774. February 2016

2014

Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation.
Heinig, K., Gätjen, M., Grau, M., Stache, V., Anagnostopoulos, I., Gerlach, K., Niesner, R.A., Cseresnyes, Z., Hauser, A.E., Lenz, P., Hehlgans, T., Brink, R., Westermann, J., Dörken, B., Lipp, M., Lenz, G., Rehm, A. and Höpken, U.E.
Cancer Discovery 4 : 1448-1465. December 2014

2012

Homeostatic chemokines guide lymphoma cells to tumor growth-promoting niches within secondary lymphoid organs.
Höpken, U.E. and Rehm, A.
Journal of Molecular Medicine 90 (11): 1237-1245. November 2012

2007

CCR7 deficiency causes ectopic lymphoid neogenesis and disturbed mucosal tissue integrity.
Höpken, U.E., Wengner, A.M., Loddenkemper, C., Stein, H., Heimesaat, M.M., Rehm, A. and Lipp, M.
Blood 109 (3): 886-895. 1 February 2007

2005

The ratio between dendritic cells and T cells determines the outcome of their encounter: Proliferation versus deletion.
Höpken, U.E., Lehmann, I., Droese, J., Lipp, M., Schueler, T. and Rehm, A.
European Journal of Immunology 35 (10): 2851-2863. 23 September 2005

EBAG9 adds a new layer of control on large dense-core vesicle exocytosis via interaction with Snapin.
Rueder, C., Reimer, T., Delgado-Martinez, I., Hermosilla, R., Engelsberg, A., Nehring, R., Doerken, B. and Rehm, A.
Molecular Biology of the Cell 16 (3): 1245-1257. 5 January 2005

Reevaluation of the 22-1-1 antibody and its putative antigen, EBAG9/RCAS1, as a tumor marker.
Reimer, T.A., Anagnostopoulos, I., Erdmann, B., Lehmann, I., Stein, H., Daniel, P., Doerken, B. and Rehm, A.
BMC Cancer 5 (1): 47. 1 January 2005

2004

HCMV-encoded chemokine receptor US28 employs multiple routes for internalization.
Droese, J., Mokros, T., Hermosilla, R., Schuelein, R., Lipp, M., Höpken, U.E. and Rehm, A.
Biochemical and Biophysical Research Communications 322 (1): 42-49. 10 September 2004

2003

The Golgi protein RCAS1 controls cell surface expression of tumor-associated O-linked glycan antigens.
Engelsberg, A., Hermosilla, R., Karsten, U., Schuelein, R., Doerken, B. and Rehm, A.
Journal of Biological Chemistry 278 (25): 22998-23007. 1 January 2003

2002

Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells.
Rehm, A., Engelsberg, A., Tortorella, D., Körner, I.J., Lehmann, I., Ploegh, H.L. and Höpken, U.E.
Journal of Virology 76 (10): 5043-5050. May 2002

Surface expression and endocytosis of the human cytomegalovirus-encoded chemokine receptor US28 is regulated by agonist-independent phosphorylation.
Mokros, T., Rehm, A., Droese, J., Oppermann, M., Lipp, M. and Höpken, U.E.
Journal of Biological Chemistry 277 (47): 45122-45128. 1 January 2002