2026
Chronic infection perturbs the affinity hierarchy of antiviral B cells.
Dimitrova, Mirela, Abreu-Mota, Tiago, Fixemer, Jonas, Bonilla, Weldy V., Marx, Anna-Friederike, Lu, Min, Tintignac, Karen, Kastner, Anna Lena, Ertuna, Yusuf I., Florova, Marianna 
ORCID: https://orcid.org/0009-0008-9529-7041, Ciancaglini, Matias ORCID: https://orcid.org/0000-0002-1296-5606, Narr, Kerstin, Stauffer, Karsten, Roux, Julien, Demougin, Philippe ORCID: https://orcid.org/0009-0002-2820-9909, Wagner, Ingrid, Merkler, Doron ORCID: https://orcid.org/0000-0002-0247-2007 and Pinschewer, Daniel D. ORCID: https://orcid.org/0000-0002-1594-3189
Proceedings of the National Academy of Sciences of the United States of America 123
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7 April 2026
FOXO1 re-expression with a dual-recombinase allele rescues class switching in germinal center B cells.
Farré Díaz, Carlota ORCID: https://orcid.org/0000-0003-4306-2108, Kabrani, Eleni ORCID: https://orcid.org/0000-0003-0834-9912, Winkler, Wiebke ORCID: https://orcid.org/0000-0001-8807-9259, Blanc, Eric ORCID: https://orcid.org/0000-0002-4369-0254, Wollert-Wulf, Brigitte ORCID: https://orcid.org/0009-0000-0257-4049, Salomon, Claudia ORCID: https://orcid.org/0009-0000-6723-6497, Wunderlich, F. Thomas ORCID: https://orcid.org/0000-0002-9209-3501, Beule, Dieter ORCID: https://orcid.org/0000-0002-3284-0632, Janz, Martin ORCID: https://orcid.org/0000-0002-1127-0044 and Rajewsky, Klaus ORCID: https://orcid.org/0000-0002-6633-6370
Journal of Experimental Medicine 223
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2 March 2026
Strong constitutive NF-κB signaling in B cells drives SLL/CLL-like lymphomagenesis and overcomes microenvironmental dependencies.
Soberón, Valeria, Osswald, Lena, Moore, Andrew, Sosnowska, Dominika, Swinerd, Gene ORCID: https://orcid.org/0000-0001-9644-9109, Chen, Jingyu, Baygün, Seren ORCID: https://orcid.org/0000-0002-3198-7632, Diehl, Carina, Seyhan, Gönül ORCID: https://orcid.org/0000-0002-3879-8009, Kraus, Laura, Gölling, Vanessa, Trapp, Ricarda, O'Neill, Thomas J. ORCID: https://orcid.org/0000-0003-2253-3118, Bortoluzzi, Sabrina, Kovacs, Daniel, Ammon, Tim, Singroul, Pankaj ORCID: https://orcid.org/0000-0001-9855-1828, Hubarzhevska, Yuliia, Öllinger, Rupert ORCID: https://orcid.org/0000-0002-2292-5982, Mueller, Sebastian ORCID: https://orcid.org/0009-0008-1514-3027, Baranov, Olga, Giansanti, Piero ORCID: https://orcid.org/0000-0003-2857-0841, Gillhuber, Felix ORCID: https://orcid.org/0009-0007-9271-4340, Grath, Sonja ORCID: https://orcid.org/0000-0003-3621-736X, Weigert, Oliver ORCID: https://orcid.org/0000-0002-0987-7373, Rosenwald, Andreas, Sasaki, Yoshiteru, Rajewsky, Klaus ORCID: https://orcid.org/0000-0002-6633-6370, Steiger, Katja ORCID: https://orcid.org/0000-0002-7269-5433, Bassermann, Florian ORCID: https://orcid.org/0000-0003-4435-2609, Rad, Roland ORCID: https://orcid.org/0000-0002-6849-9659, Krappmann, Daniel ORCID: https://orcid.org/0000-0001-7640-3234, Ringshausen, Ingo and Schmidt-Supprian, Marc ORCID: https://orcid.org/0000-0002-8543-6166
Leukemia 40
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March 2026
2025
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Radbruch, A. ORCID: https://orcid.org/0000-0001-5753-0000, Jani, P.K., Winkler, T.H. and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
European Journal of Immunology 55
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June 2025
2024
Targeted H3K9 acetylation at lncSox1 promoter by cell type-specific epigenome editing promotes intermediate progenitor proliferation in developing mouse cortex.
Sokpor, Godwin ORCID: https://orcid.org/0000-0002-7120-0793, Ulmke, P.A. ORCID: https://orcid.org/0000-0001-6960-9859, Nguyen, H.D., Pham, L., Kakani, P., Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696, Arnold, S.J. ORCID: https://orcid.org/0000-0002-2688-9210, Brand-Saberi, B. ORCID: https://orcid.org/0000-0003-3309-9724, Nguyen, H.P. and Tuoc, T. ORCID: https://orcid.org/0000-0003-2079-7259
bioRxiv
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5 November 2024
Expansion and precise CRISPR-Cas9 gene repair of autologous T memory stem cells from patients with T cell immunodeficiencies.
Li, X. ORCID: https://orcid.org/0000-0002-1173-1066, Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696, Kocks, C. ORCID: https://orcid.org/0000-0003-1749-3334 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Bio-protocol 14
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20 October 2024
In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis.
Tran, N.T. ORCID: https://orcid.org/0000-0003-0896-8641, Graf, R. ORCID: https://orcid.org/0000-0002-5400-9938, Acevedo-Ochoa, E. ORCID: https://orcid.org/0000-0001-6466-0073, Trombke, J., Weber, T. ORCID: https://orcid.org/0000-0003-2079-842X, Sommermann, T. ORCID: https://orcid.org/0000-0003-2899-0256, Salomon, C. ORCID: https://orcid.org/0009-0000-6723-6497, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696
Leukemia 38
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September 2024
In vivo sequential mutagenesis in germinal center B cells using a dual-recombinase approach: FOXO1 re-expression upon FOXO1 knockout rescues class switch recombination.
Farré Díaz, C. ORCID: https://orcid.org/0000-0003-4306-2108, Kabrani, E. ORCID: https://orcid.org/0000-0003-0834-9912, Winkler, W. ORCID: https://orcid.org/0000-0001-8807-9259, Salomon, C. ORCID: https://orcid.org/0009-0000-6723-6497, Wunderlich, F.T., Janz, M. ORCID: https://orcid.org/0000-0002-1127-0044 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
bioRxiv
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22 May 2024
Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis.
Li, X. ORCID: https://orcid.org/0000-0002-1173-1066, Wirtz, T. ORCID: https://orcid.org/0009-0005-5677-9804, Weber, T. ORCID: https://orcid.org/0000-0003-2079-842X, Lebedin, M. ORCID: https://orcid.org/0000-0002-3877-7195, Lowenstein, E.D. ORCID: https://orcid.org/0000-0003-3755-0818, Sommermann, T. ORCID: https://orcid.org/0000-0003-2899-0256, Zach, A., Yasuda, T. ORCID: https://orcid.org/0000-0001-9997-6852, de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157, Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696, Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Müller, I. ORCID: https://orcid.org/0000-0002-7477-6632, Kocks, C. ORCID: https://orcid.org/0000-0003-1749-3334 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Science Immunology 9
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2 February 2024
Epstein-Barr virus-driven B cell lymphoma mediated by a direct LMP1-TRAF6 complex.
Giehler, F., Ostertag, M.S., Sommermann, T. ORCID: https://orcid.org/0000-0003-2899-0256, Weidl, D., Sterz, K.R. ORCID: https://orcid.org/0000-0002-7225-0485, Kutz, H., Moosmann, A., Feller, S.M., Geerlof, A., Biesinger, B., Popowicz, G.M., Kirchmair, J. ORCID: https://orcid.org/0000-0003-2667-5877 and Kieser, A. ORCID: https://orcid.org/0000-0003-0783-1950
Nature Communications 15
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10 January 2024
2023
LMP1 and EBNA2 constitute a minimal set of EBV genes for transformation of human B cells.
Zhang, J., Sommermann, T. ORCID: https://orcid.org/0000-0003-2899-0256, Li, X. ORCID: https://orcid.org/0000-0002-1173-1066, Gieselmann, L., de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157, Stecklum, M., Klein, F., Kocks, C. ORCID: https://orcid.org/0000-0003-1749-3334 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Frontiers in Immunology 14
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19 December 2023
Transcriptional reprogramming by mutated IRF4 in lymphoma.
Schleussner, N. ORCID: https://orcid.org/0009-0001-3549-5600, Cauchy, P. ORCID: https://orcid.org/0000-0002-0659-0799, Franke, V. ORCID: https://orcid.org/0000-0003-3606-6792, Giefing, M., Fornes, O. ORCID: https://orcid.org/0000-0002-5969-3054, Vankadari, N. ORCID: https://orcid.org/0000-0001-9363-080X, Assi, S.A., Costanza, M. ORCID: https://orcid.org/0000-0002-8959-1083, Weniger, M.A., Akalin, A. ORCID: https://orcid.org/0000-0002-0468-0117, Anagnostopoulos, I. ORCID: https://orcid.org/0000-0002-5043-6043, Bukur, T., Casarotto, M.G. ORCID: https://orcid.org/0000-0002-0571-7671, Damm, F. ORCID: https://orcid.org/0000-0001-5553-1173, Daumke, O. ORCID: https://orcid.org/0000-0002-6190-1414, Edginton-White, B., Gebhardt, J.C.M. ORCID: https://orcid.org/0000-0003-1900-600X, Grau, M., Grunwald, S. ORCID: https://orcid.org/0000-0003-3978-6277, Hansmann, M.L., Hartmann, S. ORCID: https://orcid.org/0000-0003-3424-1091, Huber, L., Kärgel, E., Lusatis, S., Noerenberg, D., Obier, N., Pannicke, U. ORCID: https://orcid.org/0000-0002-0929-1794, Fischer, A. ORCID: https://orcid.org/0000-0002-7145-2544, Reisser, A., Rosenwald, A., Schwarz, K. ORCID: https://orcid.org/0000-0003-3178-5990, Sundararaj, S., Weilemann, A. ORCID: https://orcid.org/0009-0001-1340-6486, Winkler, W. ORCID: https://orcid.org/0000-0001-8807-9259, Xu, W., Lenz, G. ORCID: https://orcid.org/0000-0002-4728-1693, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Wasserman, W.W. ORCID: https://orcid.org/0000-0001-6098-6412, Cockerill, P.N. ORCID: https://orcid.org/0000-0002-4410-8174, Scheidereit, C. ORCID: https://orcid.org/0000-0002-0446-6129, Siebert, R., Küppers, R., Grosschedl, R. ORCID: https://orcid.org/0000-0002-0058-1250, Janz, M. ORCID: https://orcid.org/0000-0002-1127-0044, Bonifer, C. ORCID: https://orcid.org/0000-0002-4267-0825 and Mathas, S. ORCID: https://orcid.org/0000-0001-9626-1413
Nature Communications 14
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7 November 2023
An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets.
Griger, J., Widholz, S.A., Jesinghaus, M., de Andrade Krätzig, N., Lange, S., Engleitner, T., Montero, J.J., Zhigalova, E., Öllinger, R., Suresh, V., Winkler, W. ORCID: https://orcid.org/0000-0001-8807-9259, Lier, S., Baranov, O., Trozzo, R., Ben Khaled, N., Chakraborty, S., Yu, J., Konukiewitz, B., Steiger, K., Pfarr, N., Rajput, A., Sailer, D., Keller, G., Schirmacher, P., Röcken, C., Fagerstedt, K.W., Mayerle, J., Schmidt-Supprian, M., Schneider, G., Weichert, W., Calado, D.P. ORCID: https://orcid.org/0000-0001-8239-7184, Sommermann, T. ORCID: https://orcid.org/0000-0003-2899-0256, Klöppel, G., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Saur, D. and Rad, R.
Cancer Cell 41
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10 July 2023
Application of a spacer-nick gene-targeting approach to repair disease-causing mutations with increased safety.
Tran, N.T. ORCID: https://orcid.org/0000-0003-0896-8641, Lebedin, M. ORCID: https://orcid.org/0000-0002-3877-7195, Danner, E. ORCID: https://orcid.org/0000-0003-3277-5727, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696
Bio-protocol 13
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20 April 2023
Mouse models of human multiple myeloma subgroups.
Winkler, W. ORCID: https://orcid.org/0000-0001-8807-9259, Farré Díaz, C. ORCID: https://orcid.org/0000-0003-4306-2108, Blanc, E. ORCID: https://orcid.org/0000-0002-4369-0254, Napieczynska, H. ORCID: https://orcid.org/0000-0001-5091-1185, Langner, P. ORCID: https://orcid.org/0009-0007-4313-3152, Werner, M. ORCID: https://orcid.org/0000-0003-1200-807X, Walter, B. ORCID: https://orcid.org/0000-0002-0844-5958, Wollert-Wulf, B. ORCID: https://orcid.org/0009-0000-0257-4049, Yasuda, T. ORCID: https://orcid.org/0000-0001-9997-6852, Heuser, A. ORCID: https://orcid.org/0000-0002-3334-960X, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Mathas, S. ORCID: https://orcid.org/0000-0001-9626-1413, Anagnostopoulos, I., Rosenwald, A., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Janz, M. ORCID: https://orcid.org/0000-0002-1127-0044
Proceedings of the National Academy of Sciences of the United States of America 120
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7 March 2023
A CRISPR/Cas9-mediated screen identifies determinants of early plasma cell differentiation.
Xiong, E., Popp, O. ORCID: https://orcid.org/0000-0001-6240-4666, Salomon, C. ORCID: https://orcid.org/0009-0000-6723-6497, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Kocks, C. ORCID: https://orcid.org/0000-0003-1749-3334, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696
Frontiers in Immunology 13
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5 January 2023
2022
Efficient CRISPR/Cas9-mediated mutagenesis in primary human B cells for identifying plasma cell regulators.
Le, T.A., Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696, Lino, A.C., Schrezenmeier, E., Kressler, C., Hamo, D., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Dörner, T. and Dang, V.D.
Molecular Therapy - Nucleic Acids 30
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13 December 2022
miR-142 favors naïve B cell residence in peripheral lymph nodes.
Hagen, M., Chakraborty, T., Olson, W.J., Heitz, M., Hermann-Kleiter, N., Kimpel, J., Jenewein, B., Pertoll, J., Labi, V. ORCID: https://orcid.org/0000-0001-7538-1520, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Derudder, E. ORCID: https://orcid.org/0000-0003-1421-4045
Frontiers in Immunology 13
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10 November 2022
Calorie restriction enhanced glycogen metabolism to compensate for lipid insufficiency.
Hu, L., Xia, X., Zong, Y., Gu, Y., Wei, L. and Yin, J.
Molecular Nutrition & Food Research 66
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Concomitant cytotoxic effector differentiation of CD4(+) and CD8(+) T cells in response to EBV-Infected B cells.
Tamura, Y., Yamane, K., Kawano, Y., Bullinger, L. ORCID: https://orcid.org/0000-0002-5890-5510, Wirtz, T. ORCID: https://orcid.org/0009-0005-5677-9804, Weber, T. ORCID: https://orcid.org/0000-0003-2079-842X, Sander, S. ORCID: https://orcid.org/0000-0003-4645-3366, Ohki, S., Kitajima, Y. ORCID: https://orcid.org/0000-0001-6277-5918, Okada, S. ORCID: https://orcid.org/0000-0002-4622-5657, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Yasuda, T. ORCID: https://orcid.org/0000-0001-9997-6852
Cancers 14
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25 August 2022
B cell antigen receptor expression and phosphatidylinositol 3-kinase signaling regulate genesis and maintenance of mouse chronic lymphocytic leukemia.
Schmid, V.K., Khadour, A., Ahmed, N., Brandl, C., Nitschke, L., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Jumaa, H. and Hobeika, E.
Haematologica 107
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August 2022
Precise CRISPR/Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells.
Tran, N.T. ORCID: https://orcid.org/0000-0003-0896-8641, Danner, E. ORCID: https://orcid.org/0000-0003-3277-5727, Li, X. ORCID: https://orcid.org/0000-0002-1173-1066, Graf, R. ORCID: https://orcid.org/0000-0002-5400-9938, Lebedin, M. ORCID: https://orcid.org/0000-0002-3877-7195, de la Rosa, K. ORCID: https://orcid.org/0000-0003-4809-3157, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696
Science Advances 8
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3 June 2022
Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells.
Grinat, J. ORCID: https://orcid.org/0000-0003-0152-4941, Kosel, F., Goveas, N. ORCID: https://orcid.org/0000-0002-2531-5514, Kranz, A. ORCID: https://orcid.org/0000-0002-7481-0220, Alexopoulou, D. ORCID: https://orcid.org/0000-0002-3715-1756, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Sigal, M. ORCID: https://orcid.org/0000-0003-4772-0761, Stewart, A.F. and Heuberger, J. ORCID: https://orcid.org/0000-0001-7205-732X
Life Science Alliance 5
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April 2022
B cells are addicted to immunoglobulin production in the ER.
Caganova, M. ORCID: https://orcid.org/0000-0002-4576-6574, Taskiran, H., Zong, Y., Zach, A., Kabrani, E. ORCID: https://orcid.org/0000-0003-0834-9912, Schmidt, K., Goffing, P., Jellusova, J. and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
bioRxiv
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14 March 2022
2021
The magnitude of germinal center reactions is restricted by a fixed number of preexisting niches.
Avancena, P., Song, T. ORCID: https://orcid.org/0000-0002-6994-6609, Yao, Y. ORCID: https://orcid.org/0000-0003-4637-9063, Fehlner-Peach, H. ORCID: https://orcid.org/0000-0003-3021-1741, Diamond, B. ORCID: https://orcid.org/0000-0002-3250-3804, Gu, H. ORCID: https://orcid.org/0000-0002-0019-6168, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Zou, Y.R. ORCID: https://orcid.org/0000-0002-3864-8908
Proceedings of the National Academy of Sciences of the United States of America 118
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27 July 2021
ME2 promotes proneural–mesenchymal transition and lipogenesis in glioblastoma.
Yang, M., Chen, X., Zhang, J., Xiong, E., Wang, Q., Fang, W., Li, L., Fei, F. and Gong, A.
Frontiers in Oncology 11
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23 July 2021
Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation.
Aslam, M.A. ORCID: https://orcid.org/0000-0003-1905-2583, Alemdehy, M.F. ORCID: https://orcid.org/0000-0002-7936-0652, Kwesi-Maliepaard, E.M. ORCID: https://orcid.org/0000-0001-9658-1935, Muhaimin, F.I., Caganova, M. ORCID: https://orcid.org/0000-0002-4576-6574, Pardieck, I.N., van den Brand, T., van Welsem, T., de Rink, I., Song, J.Y., de Wit, E., Arens, R., Jacobs, H. ORCID: https://orcid.org/0000-0001-6227-9850 and van Leeuwen, F. ORCID: https://orcid.org/0000-0002-7267-7251
EMBO Reports 22
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3 February 2021
2020
CRISPR/Cas9-mediated ELANE mutation correction in hematopoietic stem and progenitor cells to treat severe congenital neutropenia.
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Molecular Therapy 28
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2 December 2020
B-cell-specific Myd88 L252P expression causes a premalignant gammopathy resembling IgM MGUS.
Schmidt, K., Sack, U., Graf, R. ORCID: https://orcid.org/0000-0002-5400-9938, Winkler, W. ORCID: https://orcid.org/0000-0001-8807-9259, Popp, O. ORCID: https://orcid.org/0000-0001-6240-4666, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Sommermann, T. ORCID: https://orcid.org/0000-0003-2899-0256, Kocks, C. ORCID: https://orcid.org/0000-0003-1749-3334 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Frontiers in Immunology 11
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1 December 2020
Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis.
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Proceedings of the National Academy of Sciences of the United States of America 117
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23 June 2020
Protocol for efficient CRISPR/Cas9/AAV-mediated homologous recombination in mouse hematopoietic stem and progenitor cells.
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STAR Protocols 1
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Jumaa, H., Caganova, M. ORCID: https://orcid.org/0000-0002-4576-6574, McAllister, E.J., Hoenig, L., He, X., Saltukoglu, D. ORCID: https://orcid.org/0000-0003-0959-0812, Brenker, K., Köhler, M., Leben, R., Hauser, A.E., Niesner, R. ORCID: https://orcid.org/0000-0001-8969-5432, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Reth, M. and Jellusova, J. ORCID: https://orcid.org/0000-0002-5234-2104
Life Science Alliance 3
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June 2020
Co-activation of NF-κB and MYC renders cancer cells addicted to IL6 for survival and phenotypic stability.
Barbosa, R.R., Xu, A.Q., D'Andrea, D., Copley, F., Patel, H., Chakravarty, P., Clear, A., Calaminici, M., Janz, M. ORCID: https://orcid.org/0000-0002-1127-0044, Zhang, B., Schmidt-Supprian, M., Wang, J., Gribben, J.G., Tooze, R. ORCID: https://orcid.org/0000-0003-2915-7119, Fitzgibbon, J., Franzoso, G., Rajewsky, K. and Calado, D.P. ORCID: https://orcid.org/0000-0001-8239-7184
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2019
Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat.
Labi, V. ORCID: https://orcid.org/0000-0001-7538-1520, Peng, S., Klironomos, F., Munschauer, M. ORCID: https://orcid.org/0000-0001-6143-4548, Kastelic, N., Chakraborty, T., Schoeler, K., Derudder, E. ORCID: https://orcid.org/0000-0003-1421-4045, Martella, M., Mastrobuoni, G. ORCID: https://orcid.org/0000-0003-4509-1295, Hernandez-Miranda, L.R. ORCID: https://orcid.org/0000-0002-0498-708X, Lahmann, I. ORCID: https://orcid.org/0000-0003-0640-4519, Kocks, C. ORCID: https://orcid.org/0000-0003-1749-3334, Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872, Kempa, S. ORCID: https://orcid.org/0000-0002-0696-9299, Quintanilla-Martinez de Fend, L., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Rajewsky, N. ORCID: https://orcid.org/0000-0002-4785-4332 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Genes & Development 33
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7 November 2019
The advent and rise of monoclonal antibodies.
Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Nature 575
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November 2019
B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage.
Wong, J.B., Hewitt, S.L. ORCID: https://orcid.org/0000-0003-2295-8634, Heltemes-Harris, L.M., Mandal, M. ORCID: https://orcid.org/0000-0002-0451-3896, Johnson, K., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Koralov, S.B., Clark, M.R. ORCID: https://orcid.org/0000-0003-4747-0387, Farrar, M.A. ORCID: https://orcid.org/0000-0002-5569-0366 and Skok, J.A. ORCID: https://orcid.org/0000-0002-4145-1516
Nature Communications 10
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Efficient CRISPR/Cas9-mediated gene knockin in mouse hematopoietic stem and progenitor cells.
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Cell Reports 28
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24 September 2019
TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells.
Schoeler, K., Aufschnaiter, A., Messner, S., Derudder, E. ORCID: https://orcid.org/0000-0003-1421-4045, Herzog, S., Villunger, A., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Labi, V. ORCID: https://orcid.org/0000-0001-7538-1520
FEBS Journal 286
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September 2019
Efficient and precise CRISPR/Cas9-mediated MECP2 modifications in human-induced pluripotent stem cells.
Le, T.T.H., Tran, N.T. ORCID: https://orcid.org/0000-0003-0896-8641, Dao, T.M.L., Nguyen, D.D., Do, H.D., Ha, T.L., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Nguyen, T.L., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696
Frontiers in Genetics 10
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July 2019
Enhancement of precise gene editing by the association of Cas9 with homologous recombination factors.
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Frontiers in Genetics 10
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BCR-dependent lineage plasticity in mature B cells.
Graf, R. ORCID: https://orcid.org/0000-0002-5400-9938, Seagal, J., Otipoby, K.L., Lam, K.P., Ayoub, S. ORCID: https://orcid.org/0000-0001-5043-8922, Zhang, B., Sander, S. ORCID: https://orcid.org/0000-0003-4645-3366, Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Science 363
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15 February 2019
sgRNA sequence motifs blocking efficient CRISPR/Cas9-mediated gene editing.
Graf, R. ORCID: https://orcid.org/0000-0002-5400-9938, Li, X. ORCID: https://orcid.org/0000-0002-1173-1066, Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Cell Reports 26
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29 January 2019
A novel allele for inducible Cre expression in germinal center B cells.
Weber, T. ORCID: https://orcid.org/0000-0003-2079-842X, Seagal, J., Winkler, W. ORCID: https://orcid.org/0000-0001-8807-9259, Wirtz, T. ORCID: https://orcid.org/0009-0005-5677-9804, Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
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2018
Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells.
Kabrani, E. ORCID: https://orcid.org/0000-0003-0834-9912, Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696, Tasouri, E., Sommermann, T. ORCID: https://orcid.org/0000-0003-2899-0256, Baßler, K., Ulas, T., Zenz, T., Bullinger, L. ORCID: https://orcid.org/0000-0002-5890-5510, Schultze, J.L., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Sander, S. ORCID: https://orcid.org/0000-0003-4645-3366
Blood 132
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The c-Myc/miR17-92/PTEN axis tunes PI3K activity to control expression of recombination activating genes in early B cell development.
Benhamou, D., Labi, V. ORCID: https://orcid.org/0000-0001-7538-1520, Getahun, A., Benchetrit, E., Dowery, R., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Cambier, J.C. and Melamed, D.
Frontiers in Immunology 9
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November 2018
Oncogene-specific T cells fail to eradicate lymphoma-initiating B cells in mice.
Hoser, D., Schön, C., Loddenkemper, C., Lohneis, P., Kühl, A.A., Sommermann, T. ORCID: https://orcid.org/0000-0003-2899-0256, Blankenstein, T. ORCID: https://orcid.org/0000-0002-3357-4321 and Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X
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Postnatal DNA demethylation and its role in tissue maturation.
Reizel, Y., Sabag, O., Skversky, Y., Spiro, A., Steinberg, B., Bernstein, D., Wang, A., Kieckhaefer, J., Li, C., Pikarsky, E., Levin-Klein, R., Goren, A. ORCID: https://orcid.org/0000-0001-5669-9357, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Kaestner, K.H. and Cedar, H. ORCID: https://orcid.org/0000-0001-6472-9640
Nature Communications 9
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23 May 2018
A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire.
Dobeš, J., Edenhofer, F., Vobořil, M., Brabec, T., Dobešová, M., Čepková, A., Klein, L., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Filipp, D. ORCID: https://orcid.org/0000-0003-2506-9330
European Journal of Immunology 48
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March 2018
Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4(+) and CD8(+) T cell responses.
Choi, I.K., Wang, Z., Ke, Q., Hong, M., Qian, Y., Zhao, X., Liu, Y., Kim, H.J., Ritz, J., Cantor, H., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Wucherpfennig, K.W. and Zhang, B.
Proceedings of the National Academy of Sciences of the United States of America 115
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2017
The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition.
Varano, G., Raffel, S., Sormani, M., Zanardi, F., Lonardi, S., Zasada, C. ORCID: https://orcid.org/0000-0003-1547-8317, Perucho, L., Petrocelli, V., Haake, A., Lee, A.K., Bugatti, M., Paul, U., Van Anken, E., Pasqualucci, L., Rabadan, R., Siebert, R., Kempa, S. ORCID: https://orcid.org/0000-0002-0696-9299, Ponzoni, M., Facchetti, F., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Casola, S.
Nature 546
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8 June 2017
George Klein: 1925-2016.
Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
National Academy of Sciences.
28 March 2017
EBI2 is highly expressed in multiple sclerosis lesions and promotes early CNS migration of encephalitogenic CD4 T cells.
Wanke, F., Moos, S., Croxford, A.L., Heinen, A.P., Gräf, S., Kalt, B., Tischner, D., Zhang, J., Christen, I., Bruttger, J., Yogev, N., Tang, Y., Zayoud, M., Israel, N., Karram, K., Reißig, S., Lacher, S.M., Reichhold, C., Mufazalov, I.A., Ben-Nun, A., Kuhlmann, T., Wettschureck, N., Sailer, A.W., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Casola, S., Waisman, A. and Kurschus, F.C.
Cell Reports 18
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31 January 2017
CRISPR/Cas9-mediated in vitro mutagenesis in GC-like B cells.
Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696, Graf, R. ORCID: https://orcid.org/0000-0002-5400-9938 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Methods in Molecular Biology 1623
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2017
Development of mouse model systems of germinal center lymphomas.
Kabrani, E. ORCID: https://orcid.org/0000-0003-0834-9912 and Sander, S. ORCID: https://orcid.org/0000-0003-4645-3366
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2016
Mouse model for acute Epstein-Barr virus infection.
Wirtz, T. ORCID: https://orcid.org/0009-0005-5677-9804, Weber, T. ORCID: https://orcid.org/0000-0003-2079-842X, Kracker, S., Sommermann, T. ORCID: https://orcid.org/0000-0003-2899-0256, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Yasuda, T. ORCID: https://orcid.org/0000-0001-9997-6852
Proceedings of the National Academy of Sciences of the United States of America 113
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29 November 2016
miRNAs are essential for the regulation of the PI3K/AKT/FOXO pathway and receptor editing during B cell maturation.
Coffre, M., Benhamou, D., Riess, D., Blumenberg, L., Snetkova, V., Hines, M.J., Chakraborty, T., Bajwa, S., Jensen, K., Chong, M.M.W., Getu, L., Silverman, G.J., Blelloch, R., Littman, D.R., Calado, D. ORCID: https://orcid.org/0000-0001-8239-7184, Melamed, D., Skok, J.A., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Koralov, S.B.
Cell Reports 17
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22 November 2016
Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line.
Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696, Graf, R. ORCID: https://orcid.org/0000-0002-5400-9938, Wirtz, T. ORCID: https://orcid.org/0009-0005-5677-9804, Weber, T. ORCID: https://orcid.org/0000-0003-2079-842X, Favret, J., Li, X. ORCID: https://orcid.org/0000-0002-1173-1066, Petsch, K., Tran, N.T. ORCID: https://orcid.org/0000-0003-0896-8641, Sieweke, M.H. ORCID: https://orcid.org/0000-0002-3228-9537, Berek, C., Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Proceedings of the National Academy of Sciences of the United States of America 113
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1 November 2016
TAK1 adaptor proteins TAB2 and TAB3 link the signalosome to B cell receptor-induced IKK activation.
Shinohara, H., Yasuda, T. ORCID: https://orcid.org/0000-0001-9997-6852 and Kurosaki, T.
FEBS Letters 590
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September 2016
A c-Myc/miR17-92/Pten axis controls PI3K-mediated positive and negative selection in B cell development and reconstitutes CD19 deficiency.
Benhamou, D., Labi, V. ORCID: https://orcid.org/0000-0001-7538-1520, Novak, R., Dai, I., Shafir-Alon, S., Weiss, A., Gaujoux, R., Arnold, R., Shen-Orr, S.S., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Melamed, D.
Cell Reports 16
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12 July 2016
Canonical NF-κB signaling is uniquely required for the long-term persistence of functional mature B cells.
Derudder, E. ORCID: https://orcid.org/0000-0003-1421-4045, Herzog, S., Labi, V. ORCID: https://orcid.org/0000-0001-7538-1520, Yasuda, T. ORCID: https://orcid.org/0000-0001-9997-6852, Köchert, K. ORCID: https://orcid.org/0000-0002-5548-2022, Janz, M. ORCID: https://orcid.org/0000-0002-1127-0044, Villunger, A., Schmidt-Supprian, M. and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Proceedings of the National Academy of Sciences of the United States of America 113
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3 May 2016
Tissue-specific DNA demethylation is required for proper B-cell differentiation and function.
Orlanski, S., Labi, V. ORCID: https://orcid.org/0000-0001-7538-1520, Reizel, Y., Spiro, A., Lichtenstein, M., Levin-Klein, R., Koralov, S.B., Skversky, Y., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Cedar, H. and Bergman, Y.
Proceedings of the National Academy of Sciences of the United States of America 113
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3 May 2016
Survival of Igα-deficient mature B cells requires BAFF-R function.
Levit-Zerdoun, E., Becker, M. ORCID: https://orcid.org/0000-0002-1751-1056, Pohlmeyer, R., Wilhelm, I. ORCID: https://orcid.org/0000-0002-2289-459X, Maity, P.C. ORCID: https://orcid.org/0000-0003-3295-5859, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Reth, M. and Hobeika, E.
Journal of Immunology 196
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1 March 2016
miR-23~27~24 clusters control effector T cell differentiation and function.
Cho, S., Wu, C.J., Yasuda, T. ORCID: https://orcid.org/0000-0001-9997-6852, Cruz, L.O., Khan, A.A., Lin, L.L., Nguyen, D.T., Miller, M., Lee, H.M., Kuo, M.L., Broide, D.H., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Rudensky, A.Y. and Lu, L.F.
Journal of Experimental Medicine 213
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8 February 2016
Immunological memory: lessons from the past and a look to the future.
Farber, D.L., Netea, M.G., Radbruch, A., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Zinkernagel, R.M.
Nature Reviews Immunology 16
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February 2016
Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes.
Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696, Weber, T. ORCID: https://orcid.org/0000-0003-2079-842X, Graf, R. ORCID: https://orcid.org/0000-0002-5400-9938, Sommermann, T. ORCID: https://orcid.org/0000-0003-2899-0256, Petsch, K., Sack, U., Volchkov, P., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
BMC Biotechnology 16
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16 January 2016
FOXO1 couples metabolic activity and growth state in the vascular endothelium.
Wilhelm, K., Happel, K., Eelen, G., Schoors, S., Oellerich, M.F., Lim, R., Zimmermann, B., Aspalter, I.M., Franco, C.A., Boettger, T., Braun, T., Fruttiger, M., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Keller, C., Brüning, J.C., Gerhardt, H. ORCID: https://orcid.org/0000-0002-3030-0384, Carmeliet, P. and Potente, M. ORCID: https://orcid.org/0000-0002-5689-0036
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14 January 2016
Isolation of eosinophils from the lamina propria of the murine small intestine.
Berek, C., Beller, A. and Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696
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MAP kinase cascades in antigen receptor signaling and physiology.
Yasuda, T. ORCID: https://orcid.org/0000-0001-9997-6852
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2015
PI3 kinase and FOXO1 transcription factor activity differentially control B cells in the germinal center light and dark zones.
Sander, S. ORCID: https://orcid.org/0000-0003-4645-3366, Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696, Yasuda, T. ORCID: https://orcid.org/0000-0001-9997-6852, Franklin, A., Graf, R. ORCID: https://orcid.org/0000-0002-5400-9938, Calado, D.P. ORCID: https://orcid.org/0000-0001-8239-7184, Li, S., Imami, K. ORCID: https://orcid.org/0000-0002-7451-4982, Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751, Di Virgilio, M. ORCID: https://orcid.org/0000-0001-5189-0793, Bullinger, L. ORCID: https://orcid.org/0000-0002-5890-5510 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
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15 December 2015
Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.
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Nature Immunology 16
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December 2015
The Herzenberg lecture: how to make a B-1 cell?
Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Annals of the New York Academy of Sciences 1362
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December 2015
Pop in, pop out: a novel gene-targeting strategy for use with CRISPR-Cas9.
Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803 and Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696
Genome Biology 16
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10 November 2015
Gab1 and Mapk signaling are essential in the hair cycle and hair follicle stem cell quiescence.
Akilli Öztürk, Ö., Pakula, H., Chmielowiec, J., Qi, J., Stein, S., Lan, L., Sasaki, Y., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Cell Reports 13
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20 October 2015
The B-cell antigen receptor integrates adaptive and innate immune signals.
Otipoby, K.L., Waisman, A., Derudder, E. ORCID: https://orcid.org/0000-0003-1421-4045, Srinivasan, L., Franklin, A. and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
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29 September 2015
RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.
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A rapid embryonic stem cell-based mouse model for B-cell lymphomas driven by Epstein-Barr virus protein LMP1.
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Cancer Immunology Research 3
(6): 641-649.
June 2015
An oncogenic role for alternative NF-κB signaling in DLBCL revealed upon deregulated BCL6 expression.
Zhang, B., Calado, D.P. ORCID: https://orcid.org/0000-0001-8239-7184, Wang, Z., Froehler, S. ORCID: https://orcid.org/0000-0001-8000-2927, Koechert, K. ORCID: https://orcid.org/0000-0002-5548-2022, Qian, Y., Koralov, S.B., Schmidt-Supprian, M., Sasaki, Y., Unitt, C., Rodig, S., Chen, W. ORCID: https://orcid.org/0000-0003-3263-1627, Dalla-Favera, R., Alt, F.W., Pasqualucci, L. and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Cell Reports 11
(5): 715-726.
5 May 2015
Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.
Chu, V.T. ORCID: https://orcid.org/0000-0003-1327-8696, Weber, T. ORCID: https://orcid.org/0000-0003-2079-842X, Wefers, B., Wurst, W., Sander, S. ORCID: https://orcid.org/0000-0003-4645-3366, Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803
Nature Biotechnology 33
(5): 543-548.
May 2015
How cell death shapes cancer.
Labi, V. ORCID: https://orcid.org/0000-0001-7538-1520 and Erlacher, M.
Cell Death & Disease 6
: e1675.
5 March 2015
The DNA deamination model of somatic antibody diversification.
Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Journal of Immunology 194
(5): 2041-2042.
1 March 2015
VH replacement in primary immunoglobulin repertoire diversification.
Sun, A., Novobrantseva, T.I., Coffre, M., Hewitt, S.L., Jensen, K., Skok, J.A., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Koralov, S.B.
Proceedings of the National Academy of Sciences of the United States of America 112
(5): E458-E466.
3 February 2015
TET proteins and 5-methylcytosine oxidation in hematological cancers.
Ko, M., An, J., Pastor, W.A., Koralov, S.B., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Rao, A.
Immunological Reviews 263
(1): 6-21.
January 2015
Roles of microRNAs in B lymphocyte physiology and oncogenesis.
Muljo, S.A. and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
In:
Molecular Biology of B Cells.
Academic Press, 65-73.
ISBN 978-0-12-397933-9
2015
2014
Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma.
Kreher, S., Bouhlel, M.A., Cauchy, P., Lamprecht, B., Li, S., Grau, M., Hummel, F., Köchert, K. ORCID: https://orcid.org/0000-0002-5548-2022, Anagnostopoulos, I., Jöhrens, K., Hummel, M., Hiscott, J., Wenzel, S.S., Lenz, P., Schneider, M., Küppers, R., Scheidereit, C. ORCID: https://orcid.org/0000-0002-0446-6129, Giefing, M., Siebert, R., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Lenz, G., Cockerill, P.N., Janz, M. ORCID: https://orcid.org/0000-0002-1127-0044, Dörken, B. ORCID: https://orcid.org/0000-0001-7991-3643, Bonifer, C. and Mathas, S. ORCID: https://orcid.org/0000-0001-9626-1413
Proceedings of the National Academy of Sciences of the United States of America 111
(42): E4513-E4522.
21 October 2014
IKK phosphorylates RelB to modulate its promoter specificity and promote fibroblast migration downstream of TNF receptors.
Authier, H., Billot, K., Derudder, E. ORCID: https://orcid.org/0000-0003-1421-4045, Bordereaux, D., Riviere, P., Rodrigues-Ferreira, S., Nahmias, C. and Baud, V.
Proceedings of the National Academy of Sciences of the United States of America 111
(41): 14794-14799.
14 October 2014
STAT3 activation in Th17 and Th22 cells controls IL-22-mediated epithelial host defense during infectious colitis.
Backert, I., Koralov, S.B., Wirtz, S., Kitowski, V., Billmeier, U., Martini, E., Hofmann, K., Hildner, K., Wittkopf, N., Brecht, K., Waldner, M., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Neurath, M.F., Becker, C. and Neufert, C.
Journal of Immunology 193
(7): 3779-3791.
1 October 2014
B-cell expansion and lymphomagenesis induced by chronic CD40 signaling is strictly dependent on CD19.
Hojer, C., Frankenberger, S., Strobl, L.J., Feicht, S., Djermanovic, K., Jagdhuber, F., Hömig-Hölzel, C., Ferch, U., Ruland, J., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Zimber-Strobl, U.
Cancer Research 74
(16): 4318-4328.
15 August 2014
Generation of memory B cells inside and outside germinal centers.
Takemori, T., Kaji, T., Takahashi, Y., Shimoda, M. and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
European Journal of Immunology 44
(5): 1258-1264.
May 2014
Skewed B cell differentiation affects lymphoid organogenesis but not T cell-mediated autoimmunity.
Colombo, E., Tentorio, P., Musio, S., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Pedotti, R., Casola, S. and Farina, C.
Clinical and Experimental Immunology 176
(1): 58-65.
April 2014
Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine.
Heuberger, J. ORCID: https://orcid.org/0000-0001-7205-732X, Kosel, F., Qi, J., Grossmann, K.S., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829
Proceedings of the National Academy of Sciences of the United States of America 111
(9): 3472-3477.
4 March 2014
Michael S. Neuberger 1953-2013.
Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Proceedings of the National Academy of Sciences of the United States of America 111
(8): 2862-2863.
25 February 2014
Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination.
Sheean, M.E. ORCID: https://orcid.org/0000-0003-3055-0495, McShane, E. ORCID: https://orcid.org/0000-0002-7806-2063, Cheret, C. ORCID: https://orcid.org/0000-0001-7382-0403, Walcher, J., Müller, T. ORCID: https://orcid.org/0000-0001-8096-1853, Wulf-Goldenberg, A., Hoelper, S., Garratt, A.N. ORCID: https://orcid.org/0000-0001-9631-3041, Krüger, M., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Meijer, D., Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829, Lewin, G.R. ORCID: https://orcid.org/0000-0002-2890-6352, Selbach, M. ORCID: https://orcid.org/0000-0003-2454-8751 and Birchmeier, C. ORCID: https://orcid.org/0000-0002-2041-8872
Genes & Development 28
(3): 290-303.
1 February 2014
2013
Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice.
Yasuda, T. ORCID: https://orcid.org/0000-0001-9997-6852, Wirtz, T. ORCID: https://orcid.org/0009-0005-5677-9804, Zhang, B., Wunderlich, T., Schmidt-Supprian, M., Sommermann, T. ORCID: https://orcid.org/0000-0003-2899-0256 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Cold Spring Harbor Symposia on Quantitative Biology 78
: 259-263.
15 November 2013
Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes.
Kreslavsky, T., Kim, H.J., Koralov, S.B., Ghitza, D., Buch, T., Cantor, H., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and von Boehmer, H.
Journal of Experimental Medicine 210
(10): 1911-1918.
23 September 2013
T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia.
Fogli, L.K., Sundrud, M.S., Goel, S., Bajwa, S., Jensen, K., Derudder, E. ORCID: https://orcid.org/0000-0003-1421-4045, Sun, A., Coffre, M., Uyttenhove, C., Van Snick, J., Schmidt-Supprian, M., Rao, A., Grunig, G., Durbin, J., Casola, S.S., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Koralov, S.B.
Journal of Immunology 191
(6): 3100-3111.
15 September 2013
MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways.
Jin, H.Y., Oda, H., Lai, M., Skalsky, R.L., Bethel, K., Shepherd, J., Kang, S.G., Liu, W.H., Sabouri-Ghomi, M., Cullen, B.R., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Xiao, C.
EMBO Journal 32
(17): 2377-2391.
28 August 2013
Years in Cologne.
Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Annual Review of Immunology 31
: 1-29.
March 2013
Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.
Wang, D., Höing, S., Patterson, H.C., Ahmad, U.M., Rathinam, V.A.K., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370, Fitzgerald, K.A. and Golenbock, D.T.
Journal of Biological Chemistry 288
(7): 4594-4601.
15 February 2013
2012
The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers.
Calado, D.P. ORCID: https://orcid.org/0000-0001-8239-7184, Sasaki, Y., Godinho, S.A., Pellerin, A., Köchert, K. ORCID: https://orcid.org/0000-0002-5548-2022, Sleckman, B.P., de Alboran, I.M., Janz, M. ORCID: https://orcid.org/0000-0002-1127-0044, Rodig, S. and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Nature Immunology 13
(11): 1092-1100.
November 2012
Burkitt lymphomagenesis linked to MYC plus PI3K in germinal center B cells.
Sander, S. ORCID: https://orcid.org/0000-0003-4645-3366 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Oncotarget 3
(10): 1066-1067.
28 October 2012
Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory.
Kaji, T., Ishige, A., Hikida, M., Taka, J., Hijikata, A., Kubo, M., Nagashima, T., Takahashi, Y., Kurosaki, T., Okada, M., Ohara, O., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Takemori, T.
Journal of Experimental Medicine 209
(11): 2079-2097.
22 October 2012
Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis.
Sander, S. ORCID: https://orcid.org/0000-0003-4645-3366, Calado, D.P. ORCID: https://orcid.org/0000-0001-8239-7184, Srinivasan, L., Köchert, K. ORCID: https://orcid.org/0000-0002-5548-2022, Zhang, B., Rosolowski, M., Rodig, S.J., Holzmann, K., Stilgenbauer, S., Siebert, R., Bullinger, L. ORCID: https://orcid.org/0000-0002-5890-5510 and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Cancer Cell 22
(2): 167-179.
14 August 2012
Immune surveillance and therapy of lymphomas driven by Epstein-Barr-Virus protein LMP1 in a mouse model.
Zhang, B., Kracker, S., Yasuda, T. ORCID: https://orcid.org/0000-0001-9997-6852, Casola, S., Vanneman, M., Hömig-Hölzel, C., Wang, Z., Derudder, E. ORCID: https://orcid.org/0000-0003-1421-4045, Li, S., Chakraborty, T., Cotter, S.E., Koyama, S., Currie, T., Freeman, G.J., Kutok, J.L., Rodig, S.J., Dranoff, G. and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Cell 148
(4): 739-751.
17 February 2012
2011
Efficient generation of B lymphocytes by recognition of self-antigens.
Eschbach, C., Bach, M.P., Fidler, I., Pelanda, R., Köhler, F., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Jumaa, H.
European Journal of Immunology 41
(8): 2397-2403.
August 2011
2010
Constitutive canonical NF-κB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma.
Calado, D.P. ORCID: https://orcid.org/0000-0001-8239-7184, Zhang, B., Srinivasan, L., Sasaki, Y., Seagal, J., Unitt, C., Rodig, S., Kutok, J., Tarakhovsky, A., Schmidt-Supprian, M. and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Cancer Cell 18
(6): 580-589.
14 December 2010
Regulation of microRNA expression and abundance during lymphopoiesis.
Kuchen, S., Resch, W., Yamane, A., Kuo, N., Li, Z., Chakraborty, T., Wei, L., Laurence, A., Yasuda, T. ORCID: https://orcid.org/0000-0001-9997-6852, Peng, S., Hu-Li, J., Lu, K., Dubois, W., Kitamura, Y., Charles, N., Sun, H.W., Muljo, S., Schwartzberg, P.L., Paul, W.E., O'Shea, J., Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370 and Casellas, R.
Immunity 32
(6): 828-839.
25 June 2010
2009
PI3 kinase signals BCR-dependent mature B cell survival.
Srinivasan, L., Sasaki, Y., Calado, D.P. ORCID: https://orcid.org/0000-0001-8239-7184, Zhang, B., Paik, J.H., DePinho, R.A., Kutok, J.L., Kearney, J.F., Otipoby, K.L. and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Cell 139
(3): 573-586.
30 October 2009
MicroRNA control in the immune system: basic principles.
Xiao, C. and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Cell 136
(1): 26-36.
9 January 2009
2002
TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2.
Pasparakis, Manolis, Courtois, Gilles, Hafner, Martin, Schmidt-Supprian, Marc, Nenci, Arianna, Toksoy, Atiye, Krampert, Monika, Goebeler, Matthias, Gillitzer, Reinhard, Israel, Alain, Krieg, Thomas, Rajewsky, Klaus ORCID: https://orcid.org/0000-0002-6633-6370 and Haase, Ingo
Nature 417
(6891): 861-6.
20 June 2002
1993
Pillars article: independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting.
Gu, H., Zou, Y.R. and Rajewsky, K. ORCID: https://orcid.org/0000-0002-6633-6370
Cell 73
(6): 1155-1164.
18 June 1993
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