Browse by Research Team

2023

PI3K-C2β limits mTORC1 signaling and angiogenic growth.
Kobialka, P. and Llena, J. and Deleyto-Seldas, N. and Munar-Gelabert, M. and Dengra, J.A. and Villacampa, P. and Albinyà-Pedrós, A. and Muixi, L. and Andrade, J. and van Splunder, H. and Angulo-Urarte, A. and Potente, M. and Grego-Bessa, J. and Castillo, S.D. and Vanhaesebroeck, B. and Efeyan, A. and Graupera, M.
Science Signaling 16 (813): eadg1913. November 2023

Inhibition of fatty acid oxidation enables heart regeneration in adult mice.
Li, X. and Wu, F. and Günther, S. and Looso, M. and Kuenne, C. and Zhang, T. and Wiesnet, M. and Klatt, S. and Zukunft, S. and Fleming, I. and Poschet, G. and Wietelmann, A. and Atzberger, A. and Potente, M. and Yuan, X. and Braun, T.
Nature 622 (7983): 619-626. 19 October 2023

Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2.
Li, R. and Shao, J. and Jin, Y.J. and Kawase, H. and Ong, Y.T. and Troidl, K. and Quan, Q. and Wang, L. and Bonnavion, R. and Wietelmann, A. and Helmbacher, F. and Potente, M. and Graumann, J. and Wettschureck, N. and Offermanns, S.
Nature Communications 14 (1): 1980. 8 April 2023

Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine.
Wu, F. and Li, X. and Looso, M. and Liu, H. and Ding, D. and Günther, S. and Kuenne, C. and Liu, S. and Weissmann, N. and Boettger, T. and Atzberger, A. and Kolahian, S. and Renz, H. and Offermanns, S. and Gärtner, U. and Potente, M. and Zhou, Y. and Yuan, X. and Braun, T.
Nature Genetics 55 (1): 100-111. January 2023

2022

Hydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics.
Ferrante, F. and Giaimo, B.D. and Friedrich, T. and Sugino, T. and Mertens, D. and Kugler, S. and Gahr, B.M. and Just, S. and Pan, L. and Bartkuhn, M. and Potente, M. and Oswald, F. and Borggrefe, T.
Cell Death & Disease 13 (7): 600. 12 July 2022

A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth.
Ong, Y.T. and Andrade, J. and Armbruster, M. and Shi, C. and Castro, M. and Costa, A.S.H. and Sugino, T. and Eelen, G. and Zimmermann, B. and Wilhelm, K. and Lim, J. and Watanabe, S. and Guenther, S. and Schneider, A. and Zanconato, F. and Kaulich, M. and Pan, D. and Braun, T. and Gerhardt, H. and Efeyan, A. and Carmeliet, P. and Piccolo, S. and Grosso, A.R. and Potente, M.
Nature Metabolism 4 (6): 672-682. June 2022

The blood-brain barrier-a metabolic ecosystem.
Castro, M. and Potente, M.
EMBO Journal 41 (9): e111189. 2 May 2022

Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load.
Kaneshige, A. and Kaji, T. and Zhang, L. and Saito, H. and Nakamura, A. and Kurosawa, T. and Ikemoto-Uezumi, M. and Tsujikawa, K. and Seno, S. and Hori, M. and Saito, Y. and Matozaki, T. and Maehara, K. and Ohkawa, Y. and Potente, M. and Watanabe, S. and Braun, T. and Uezumi, A. and Fukada, S.I.
Cell Stem Cell 29 (2): 265-280. 3 February 2022

Locus-conserved circular RNA cZNF292 controls endothelial cell flow responses.
Heumüller, A.W. and Jones, A. N. and Mourão, A. and Klangwart, M. and Shi, C. and Wittig, I. and Fischer, A. and Muhly Reinholz, M. and Buchmann, G.K. and Dieterich, C. and Potente, M. and Braun, T. and Grote, P. and Jaé, N. and Sattler, M. and Dimmeler, S.
Circulation Research 130 (1): 67-79. 7 January 2022

2021

Regional specialization and fate specification of bone stromal cells in skeletal development.
Sivaraj, K.K. and Jeong, H.W. and Dharmalingam, B. and Zeuschner, D. and Adams, S. and Potente, M. and Adams, R.H.
Cell Reports 36 (2): 109352. 13 July 2021

Post-myocardial infarction heart failure dysregulates the bone vascular niche.
Hoffmann, J. and Luxán, G. and Abplanalp, W.T. and Glaser, S.F. and Rasper, T. and Fischer, A. and Muhly-Reinholz, M. and Potente, M. and Assmus, B. and John, D. and Zeiher, A.M. and Dimmeler, S.
Nature Communications 12 (1): 3964. 25 June 2021

PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.
Ren, A.A. and Snellings, D.A. and Su, Y.S. and Hong, C.C. and Castro, M. and Tang, A.T. and Detter, M.R. and Hobson, N. and Girard, R. and Romanos, S. and Lightle, R. and Moore, T. and Shenkar, R. and Benavides, C. and Beaman, M.M. and Mueller-Fielitz, H. and Chen, M. and Mericko, P. and Yang, J. and Sung, D.C. and Lawton, M.T. and Ruppert, M. and Schwaninger, M. and Körbelin, J. and Potente, M. and Awad, I.A. and Marchuk, D.A. and Kahn, M.L.
Nature 594 (7862): :271-276. 10 June 2021

Control of endothelial quiescence by FOXO-regulated metabolites.
Andrade, J. and Shi, C. and Costa, A.S.H. and Choi, J. and Kim, J. and Doddaballapur, A. and Sugino, T. and Ong, Y.T. and Castro, M. and Zimmermann, B. and Kaulich, M. and Guenther, S. and Wilhelm, K. and Kubota, Y. and Braun, T. and Koh, G.Y. and Grosso, A.R. and Frezza, C. and Potente, M.
Nature Cell Biology 23 : 413-423. April 2021

Arterialization requires the timely suppression of cell growth.
Luo, W. and Garcia-Gonzalez, I. and Fernández-Chacón, M. and Casquero-Garcia, V. and Sanchez-Muñoz, M.S. and Mühleder, S. and Garcia-Ortega, L. and Andrade, J. and Potente, M. and Benedito, R.
Nature 589 (7842): 437-441. 21 January 2021

11,12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27(Kip1).
Potente, M. and Fisslthaler, B. and Busse, R. and Fleming, I.
Journal of Biological Chemistry 278 (32): 29619-29625. 4 January 2021

Cytochrome P450 2C9-induced endothelial cell proliferation involves induction of mitogen-activated protein (MAP) kinase phosphatase-1, inhibition of the c-Jun N-terminal kinase, and up-regulation of cyclin D1.
Potente, M. and Michaelis, U.R. and Fisslthaler, B. and Busse, R. and Fleming, I.
Journal of Biological Chemistry 277 (18): 15671-15676. 4 January 2021

2020

YAP and TAZ protect against white adipocyte cell death during obesity.
Wang, L. and Wang, S.P. and Shi, Y. and Li, R. and Günther, S. and Ong, Y.T. and Potente, M. and Yuan, Z. and Liu, E. and Offermanns, S.
Nature Communications 11 (1): 5455. 28 October 2020

Apelin signaling drives vascular endothelial cells towards a pro-angiogenic state.
Helker, C.S.M. and Eberlein, J. and Wilhelm, K. and Sugino, T. and Malchow, J. and Schuermann, A. and Baumeister, S. and Kwon, H.B. and Maischein, H.M. and Potente, M. and Herzog, W. and Stainier, D.Y.R.
eLife 9 : e55589. 21 September 2020

Endothelial cells don't waste: endothelial-derived lactate boosts muscle regeneration.
Castro, M. and Andrade, J. and Potente, M.
Developmental Cell 54 (2): 137-139. 20 July 2020

2019

Metabolic modulation regulates cardiac wall morphogenesis in zebrafish.
Fukuda, R. and Aharonov, A. and Ong, Y.T. and Stone, O.A. and El-Brolosy, M. and Maischein, H.M. and Potente, M. and Tzahor, El. and Stainier, D.Y.R.
eLife 8 23 December 2019

Deubiquitinase USP10 regulates Notch signaling in the endothelium.
Lim, R. and Sugino, T. and Nolte, H. and Andrade, J. and Zimmermann, B. and Shi, C. and Doddaballapur, A. and Ong, Y.T. and Wilhelm, K. and Fasse, J.W.D. and Ernst, A. and Kaulich, M. and Husnjak, K. and Boettger, T. and Guenther, S. and Braun, T. and Krüger, M. and Benedito, R. and Dikic, I. and Potente, M.
Science 364 (6436): 188-193. 12 April 2019

Endothelial metabolism - more complex (III) than previously thought.
Andrade, J. and Potente, M.
Nature Metabolism 1 (1): 14-15. January 2019

2018

aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability.
Riddell, M. and Nakayama, A. and Hikita, T. and Mirzapourshafiyi, F. and Kawamura, T. and Pasha, A. and Li, M. and Masuzawa, M. and Looso, M. and Steinbacher, T. and Ebnet, K. and Potente, M. and Hirose, T. and Ohno, S. and Fleming, I. and Gattenlöhner, S. and Aung, P.P. and Phung, T. and Yamasaki, O. and Yanagi, T. and Umemura, H. and Nakayama, M.
Nature Communications 9 (1): 5357. 17 December 2018

Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells.
Stone, O.A. and El-Brolosy, M. and Wilhelm, K. and Liu, X. and Romão, A.M. and Grillo, E. and Lai, J.K.H. and Günther, S. and Jeratsch, S. and Kuenne, C. and Lee, I.C. and Braun, T. and Santoro, M.M. and Locasale, J.W. and Potente, M. and Stainier, D.Y.R.
Nature Communications 9 (1): 4077. 9 October 2018

Top-NOTCH regulation of cardiac metabolism.
Lim, R. and Potente, M.
Circulation 137 (24): 2609-2612. 12 June 2018

Visualization of endothelial cell cycle dynamics in mouse using the Flt-1/eGFP-anillin system.
Herz, K. and Becker, A. and Shi, C. and Ema, M. and Takahashi, S. and Potente, M. and Hesse, M. and Fleischmann, B.K. and Wenzel, D.
Angiogenesis 21 (2): 349-361. May 2018

YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development.
Neto, F. and Klaus-Bergmann, A. and Ong, Y.T. and Alt, S. and Vion, A.C. and Szymborska, A. and Carvalho, J.R. and Hollfinger, I. and Bartels-Klein, E. and Franco, C.A. and Potente, M. and Gerhardt, H.
eLife 7 : e31037. 5 February 2018

2017

New Q(ues) to keep blood vessels growing.
Andrade, J. and Potente, M.
EMBO Journal 36 (16): 2315-2317. 15 August 2017

YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development.
Neto, F. and Klaus-Bergmann, A. and Ong, Y.T. and Alt, S. and Vion, A.C. and Szymborska, A. and Carvalho, J.R. and Hollfinger, I. and Bartels-Klein, E. and Franco, C.A. and Potente, M. and Gerhardt, H.
bioRxiv : 174185. 9 August 2017

Vascular heterogeneity and specialization in development and disease.
Potente, M. and Mäkinen, T.
Nature Reviews Molecular Cell Biology 18 (8): 477-494. August 2017

FGF-dependent metabolic control of vascular development.
Yu, P. and Wilhelm, K. and Dubrac, A. and Tung, J.K. and Alves, T.C. and Fang, J.S. and Xie, Y. and Zhu, Ji. and Chen, Z. and De Smet, F. and Zhang, J. and Jin, S.W. and Sun, L. and Sun, H. and Kibbey, R.G. and Hirschi, K.K. and Hay, N. and Carmeliet, P. and Chittenden, T.W. and Eichmann, A. and Potente, M. and Simons, M.
Nature 545 (7653): 224-228. 11 May 2017

The link between angiogenesis and endothelial metabolism.
Potente, M. and Carmeliet, P.
Annual Review of Physiology 79 : 43-66. 10 February 2017

2016

Metabolische Regulation des Blutgefäßwachstums [Metabolic regulation of blood vessel growth].
Wilhelm, K. and Potente, M.
BIOspektrum 22 (6): 597-599. 2 October 2016

FOXO1 couples metabolic activity and growth state in the vascular endothelium.
Wilhelm, K. and Happel, K. and Eelen, G. and Schoors, S. and Oellerich, M.F. and Lim, R. and Zimmermann, B. and Aspalter, I.M. and Franco, C.A. and Boettger, T. and Braun, T. and Fruttiger, M. and Rajewsky, K. and Keller, C. and Brüning, J.C. and Gerhardt, H. and Carmeliet, P. and Potente, M.
Nature 529 (7585): 216-220. 14 January 2016

2015

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis.
Serra, H. and Chivite, I. and Angulo-Urarte, A. and Soler, A. and Sutherland, J.D. and Arruabarrena-Aristorena, A. and Ragab, A. and Lim, R. and Malumbres, M. and Fruttiger, M. and Potente, M. and Serrano, M. and Fabra, A. and Vinals, F. and Casanovas, O. and Pandolfi, P.P. and Bigas, A. and Carracedo, A. and Gerhardt, H. and Graupera, M.
Nature Communications 6 : 7935. 31 July 2015

Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy.
Domigan, C.K. and Warren, C.M. and Antanesian, V. and Happel, K. and Ziyad, S. and Lee, S. and Krall, A. and Duan, L. and Torres-Collado, A.X. and Castellani, L.W. and Elashoff, D. and Christofk, H.R. and van der Bliek, A.M. and Potente, M. and Iruela-Arispe, M.L.
Journal of Cell Science 128 (12): 2236-2248. 15 June 2015

Laminar shear stress inhibits endothelial cell metabolism via KLF2-mediated repression of PFKFB3.
Doddaballapur, A. and Michalik, K.M. and Manavski, Y. and Lucas, T. and Houtkooper, R.H. and You, X. and Chen, W. and Zeiher, A.M. and Potente, M. and Dimmeler, S. and Boon, R.A.
Arteriosclerosis Thrombosis and Vascular Biology 35 (1): 137-145. January 2015

2013

PP2A regulatory subunit Bα controls endothelial contractility and vessel lumen integrity via regulation of HDAC7.
Martin, M. and Geudens, I. and Bruyr, J. and Potente, M. and Bleuart, A. and Lebrun, M. and Simonis, N. and Deroanne, C. and Twizere, J.C. and Soubeyran, P. and Peixoto, P. and Mottet, D. and Janssens, V. and Hofmann, W.K. and Claes, F. and Carmeliet, P. and Kettmann, R. and Gerhardt, H. and Dequiedt, F.
EMBO Journal 32 (18): 2491-2503. 11 September 2013

Regulation of angiogenesis by PI3K signaling networks.
Graupera, M. and Potente, M.
Experimental Cell Research 319 (9): 1348-1355. 15 May 2013

The polarity protein Scrib is essential for directed endothelial cell migration.
Michaelis, U.R. and Chavakis, E. and Kruse, C. and Jungblut, B. and Kaluza, D. and Wandzioch, K. and Manavski, Y. and Heide, H. and Santoni, M.J. and Potente, M. and Eble, J.A. and Borg, J.P. and Brandes, R.P.
Circulation Research 112 (6): 924-934. 15 March 2013

MicroRNA-34a regulates cardiac ageing and function.
Boon, R.A. and Iekushi, K. and Lechner, S. and Seeger, T. and Fischer, A. and Heydt, S. and Kaluza, D. and Tréguer, K. and Carmona, G. and Bonauer, A. and Horrevoets, A.J.G. and Didier, N. and Girmatsion, Z. and Biliczki, P. and Ehrlich, J.R. and Katus, H.A. and Müller, O.J. and Potente, M. and Zeiher, A.M. and Hermeking, H. and Dimmeler, S.
Nature 495 (7439): 107-110. 7 March 2013

2012

FOXOs and sirtuins in vascular growth, maintenance, and aging.
Oellerich, M.F. and Potente, M.
Circulation Research 110 (9): 1238-51. 27 April 2012

Venoarterielle ECMO als "bridge to recovery": Kardiogener Schock und Verdacht auf Myokarditis bei einer 37-Jährigen [Veno-arterial ECMO as bridge to recovery. Cardiogenic shock and suspected myocarditis in a 37-year-old patient].
Fox, H. and Seeger, F.H. and Schmitt, J. and Potente, M. and Dzemali, O. and Fichtlscherer, S. and Ehrlich, J.R.
Medizinische Klinik, Intensivmedizin und Notfallmedizin 107 (3): 206-212. April 2012

2011

Basic and therapeutic aspects of angiogenesis.
Potente, M. and Gerhardt, H. and Carmeliet, P.
Cell 146 (6): 873-887. 16 September 2011

Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
Guarani, V. and Deflorian, G. and Franco, C.A. and Krüger, M. and Phng, L.K. and Bentley, K. and Toussaint, L. and Dequiedt, F. and Mostoslavsky, R. and Schmidt, M.H.H. and Zimmermann, B. and Brandes, R.P. and Mione, M. and Westphal, C.H. and Braun, T. and Zeiher, A.M. and Gerhardt, H. and Dimmeler, S. and Potente, M.
Nature 473 (7346): 234-238. 12 May 2011

2010

An energy-sensor network takes center stage during endothelial aging.
Potente, M.
Circulation Research 106 (8): 1316-1318. 30 April 2010

SIRT1 - a metabolic sensor that controls blood vessel growth.
Guarani, V. and Potente, M.
Current Opinion in Pharmacology 10 (2): 139-145. April 2010

2009

MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice.
Bonauer, A. and Carmona, G. and Iwasaki, M. and Mione, M. and Koyanagi, M. and Fischer, A. and Burchfield, J. and Fox, H. and Doebele, C. and Ohtani, K. and Chavakis, E. and Potente, M. and Tjwa, M. and Urbich, C. and Zeiher, A.M. and Dimmeler, S.
Science 324 (5935): 1710-1713. 26 June 2009

HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells.
Urbich, C. and Rössig, L. and Kaluza, D. and Potente, M. and Boeckel, J.N. and Knau, A. and Diehl, F. and Geng, J.G. and Hofmann, W.K. and Zeiher, A.M. and Dimmeler, S.
Blood 113 (22): 5669-5679. 28 May 2009

Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis.
Phng, L.K. and Potente, M. and Leslie, J.D. and Babbage, J. and Nyqvist, D. and Lobov, I. and Ondr, J.K. and Rao, S. and Lang, R.A. and Thurston, G. and Gerhardt, H.
Developmental Cell 16 (1): 70-82. 20 January 2009

2008

NO targets SIRT1: a novel signaling network in endothelial senescence.
Potente, M. and Dimmeler, S.
Arteriosclerosis Thrombosis and Vascular Biology 28 (9): 1577-1579. September 2008

Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5.
Taddei, A. and Giampietro, C. and Conti, A. and Orsenigo, F. and Breviario, F. and Pirazzoli, V. and Potente, M. and Daly, C. and Dimmeler, S. and Dejana, E.
Nature Cell Biology 10 (8): 923-934. August 2008

Emerging roles of SIRT1 in vascular endothelial homeostasis.
Potente, M. and Dimmeler, S.
Cell Cycle 7 (14): 2117-2122. 15 July 2008

Protein phosphatase 2A controls the activity of histone deacetylase 7 during T cell apoptosis and angiogenesis.
Martin, M. and Potente, M. and Janssens, V. and Vertommen, D. and Twizere, J.C. and Rider, M.H. and Goris, J. and Dimmeler, S. and Kettmann, R. and Dequiedt, F.
Proceedings of the National Academy of Sciences of the United States of America 105 (12): 4727-4732. 25 March 2008

2007

SIRT1 controls endothelial angiogenic functions during vascular growth.
Potente, M. and Ghaeni, L. and Baldessari, D. and Mostoslavsky, R. and Rossig, L. and Dequiedt, F. and Haendeler, J. and Mione, M. and Dejana, E. and Alt, F.W. and Zeiher, A.M. and Dimmeler, S.
Genes & Development 21 (20): 2644-2658. 15 October 2007

2005

Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization.
Potente, M. and Urbich, C. and Sasaki, K.I. and Hofmann, W.K. and Heeschen, C. and Aicher, A. and Kollipara, R. and DePinho, R.A. and Zeiher, A.M. and Dimmeler, S.
Journal of Clinical Investigation 115 (9): 2382-2392. 1 September 2005

Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells.
Rössig, L. and Urbich, C. and Brühl, T. and Dernbach, E. and Heeschen, C. and Chavakis, E. and Sasaki, K.I. and Aicher, D. and Diehl, F. and Seeger, F. and Potente, M. and Aicher, A. and Zanetta, L. and Dejana, E. and Zeiher, A.M. and Dimmeler, S.
Journal of Experimental Medicine 201 (11): 1825-35. 6 June 2005

FOXO-dependent expression of the proapoptotic protein Bim: pivotal role for apoptosis signaling in endothelial progenitor cells.
Urbich, C. and Knau, A. and Fichtlscherer, S. and Walter, D.H. and Brühl, T. and Potente, M. and Hofmann, W.K. and de Vos, S. and Zeiher, A.M. and Dimmeler, S.
FASEB Journal 19 (8): 974-976. June 2005

1999

Cytochrome P450 2C is an EDHF synthase in coronary arteries.
Fisslthaler, B. and Popp, R. and Kiss, L. and Potente, M. and Harder, D.R. and Fleming, I. and Busse, R.
Nature 401 (6752): 493-497. 30 September 1999